Surgery for Obesity and Related Diseases最新文献

英文中文

Improvement in breathlessness following bariatric surgery as measured by a new heart failure–specific health-related quality of life instrument: a prospective longitudinal study 通过一种新的心力衰竭特异性健康相关生活质量仪器测量的减肥手术后呼吸困难的改善：一项前瞻性纵向研究

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.09.014

Hila Zelicha R.D., Ph.D. , Zachary N. Weitzner M.D. , Seuna Park N.P. , Tony G. Babb Ph.D. , Vipa Bernhardt Ph.D. , Faraz S. Ahmad M.D., M.S. , David Cella Ph.D. , Yijun Chen M.D. , Edward H. Livingston M.D.

Background

There is a need for an instrument that efficiently identifies heart failure (HF) symptoms in patients with obesity.

Objectives

To determine the spectrum of HF symptoms in patients with severe obesity who lose weight following bariatric surgery using a new, validated HF health-related quality of life (HRQOL) instrument, Patient-Reported Outcomes Measurement Information System (PROMIS) + HF-27.

Setting

Health academic quaternary care center in the United States.

Methods

Prospective longitudinal 12-month cohort study. PROMIS + HF-27 HRQOL surveys were administered before and 1 year after sleeve gastrectomy. T-scores anchoring HRQOL domain scores to the U.S. general population were calculated. Dyspnea T-scores were centered on a chronic obstructive pulmonary disease reference population.

Results

Of 40 patients at baseline, 33 (83%) reported some degree of dyspnea: mild n = 18 (55%), moderate n = 12 (36%), and severe n = 3 (9%) on the PROMIS + HF-27 survey. Only 1 patient had been given a clinical diagnosis of dyspnea during routine primary care visits. Dyspnea, physical function, fatigue, sleep disorders, and pain T-scores were significantly improved (dyspnea: preoperative: 45.3 ± 8.2, postoperative: 35.6 ± 4.9, P < .0001; physical function: preoperative: 47.7 ± 7.6, postoperative: 52.3 ± 5.3, P = .001; fatigue: preoperative: 54.5 ± 8.6, postoperative: 45.7 ± 8.1, P < .000; sleep disorders: preoperative: 52.1 ± 8.5, postoperative: 46.6 ± 7.8, P = .002; pain: preoperative: 55.1 ± 9.4, postoperative: 47.3 ± 6.2, P < .0001; n = 40). Depression and cognitive disturbances T-scores did not significantly change after surgery (P > .05 for all). Summary scores for physical function, social roles, mental function, and the overall HRQOL total score were significantly improved 1 year after bariatric surgery (P < .05). None of the summary scores or the domain T-scores, including dyspnea, were significantly associated with weight loss adjusted for sex, age, and preoperative weight.

Conclusions

PROMIS + HF-27 efficiently measured and detected improvements in multiple obesity-relevant HRQOL domains following sleeve gastrectomy. Of these, dyspnea was the most prominent and showed the largest improvement after bariatric surgery.

背景：需要一种能有效识别肥胖患者心力衰竭（HF）症状的仪器。目的：利用一种新的、经过验证的HF健康相关生活质量（HRQOL）仪器——患者报告的结局测量信息系统(PROMIS) + HF-27，确定在减肥手术后体重减轻的严重肥胖患者的HF症状谱。背景：美国卫生学术四级保健中心。方法：前瞻性纵向12个月队列研究。在袖式胃切除术前和术后1年进行PROMIS + HF-27 HRQOL调查。计算将HRQOL领域分数锚定到美国一般人群的t分数。呼吸困难t评分集中于慢性阻塞性肺疾病参考人群。结果：在40例基线患者中，33例（83%）报告了一定程度的呼吸困难：PROMIS + HF-27调查中，轻度n = 18(55%)，中度n = 12(36%)，重度n = 3（9%）。在常规的初级保健访问中，只有1例患者被诊断为呼吸困难。呼吸困难、身体功能、疲劳、睡眠障碍和疼痛t指数显著提高(术后:呼吸困难:术前:45.3±8.2,35.6±4.9,P <。;物理性能:术前:47.7±7.6,术后:52.3±5.3,P =措施;疲劳:术前:54.5±8.6,术后:45.7±8.1,P <组织;睡眠障碍:术前:52.1±8.5,术后:46.6±7.8,P = .002;疼痛:术前:55.1±9.4,术后:47.3±6.2,P <。;n = 40)。术后抑郁和认知障碍t评分无显著变化（P < 0.05）。减肥手术后1年身体功能、社会角色、心理功能综合评分及HRQOL总评分均有显著提高（P < 0.05）。包括呼吸困难在内的总结评分和区域t评分与经性别、年龄和术前体重调整后的体重减轻均无显著相关性。结论：PROMIS + HF-27有效地测量和检测了袖胃切除术后多个肥胖相关HRQOL域的改善。其中，呼吸困难最为突出，在减肥手术后改善最大。

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引用次数: 0

Comment on: “Effects of neoadjuvant glucagon-like-peptide 1 receptor agonists on weight loss after bariatric surgery” 评论：“新辅助胰高血糖素样肽1受体激动剂对减肥手术后体重减轻的影响”。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.001

Sean M. O’Neill M.D., Ph.D., Ryan A. Howard M.D., Hope T. Jackson M.D.

引用次数: 0

Hypoglycemia following metabolic and bariatric surgery: evidence from objective and subjective naturalistic assessment methods 代谢和减肥手术后的低血糖：来自客观和主观自然评估方法的证据。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.07.015

Gail A. Kerver Ph.D. , Kristine J. Steffen Pharm.D., Ph.D. , Glen Forester Ph.D. , Leslie A. Laam Ph.D. , Sugong Chen M.D. , Ellen Vogels D.O. , David B. Sarwer Ph.D. , Stephen A. Wonderlich Ph.D. , Scott G. Engel Ph.D.

Background

Hypoglycemia (i.e., low blood glucose) is a potential complication following metabolic and bariatric surgery (MBS) that can ultimately result in severe and deadly consequences. However, the symptoms typically associated with hypoglycemia (e.g., dizziness, anxiety) can be nonspecific, which impairs effective monitoring.

Objectives

This study utilized a unique combination of naturalistic assessments to compare the subjective self-report of hypoglycemic symptoms measured via ecological momentary assessment (EMA) with objectively-collected data from continuous glucose monitoring (CGM).

Setting

Private Hospital, United States.

Methods

Participants were 44 adults who completed 10 days of EMA and CGM 1 year after undergoing Roux-en-Y gastric bypass. Multiple times per day during the EMA protocol, participants identified how many of 18 hypoglycemic symptoms they had experienced since they were last signaled several hours earlier.

Results

CGM data showed that ∼66% of participants experienced at least one possible daytime hypoglycemic event (range = 1-23 episodes/person). The total number of hypoglycemic symptoms endorsed via EMA did not correspond with the occurrence of a possible hypoglycemic event captured by CGM (P = .145). However, multilevel models revealed that participants were more likely to report feeling “shaky”, “lightheaded”, and “coordination problems/clumsiness” (false discovery rate corrected P values < .05) during periods of time coinciding with possible hypoglycemic events identified by CGM.

Conclusions

Many patients are at risk for low blood glucose post-MBS. In the absence of objective assessment, several subjective symptoms may serve as indicators of possible hypoglycemic events following MBS.

背景：低血糖（即低血糖）是代谢和减肥手术（MBS）后的潜在并发症，最终可能导致严重和致命的后果。然而，与低血糖相关的典型症状（如头晕、焦虑）可能是非特异性的，从而影响有效监测。目的：本研究采用自然评估的独特组合，比较通过生态瞬时评估（EMA）测量的低血糖症状的主观自我报告与通过连续血糖监测（CGM）收集的客观数据。地点：美国私立医院。方法：参与者为44名成年人，他们在Roux-en-Y胃旁路手术1年后完成了10天的EMA和CGM。在EMA方案中，参与者每天多次确定自几小时前最后一次信号发出以来，他们经历了18种低血糖症状中的多少种。结果：CGM数据显示，约66%的参与者至少经历了一次可能的白天低血糖事件（范围= 1-23次/人）。EMA认可的低血糖症状总数与CGM捕获的可能低血糖事件的发生不一致（P = 0.145）。然而，多层模型显示，在与CGM识别的可能的低血糖事件相吻合的时间段内，参与者更有可能报告感觉“颤抖”、“头晕”和“协调问题/笨拙”（错误发现率校正P值< 0.05）。结论：许多患者在mbs后存在低血糖风险。在缺乏客观评估的情况下，一些主观症状可以作为MBS后可能发生低血糖事件的指标。

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引用次数: 0

Will metabolic bariatric surgery improve my patient’s mood? A careful examination of the relationship between mood, negative affect, and weight loss and recurrence after surgery 代谢减肥手术能改善病人的情绪吗？仔细检查情绪、负面影响、体重减轻和术后复发之间的关系。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.08.026

Scott G. Engel Ph.D. , Stephen A. Wonderlich Ph.D. , Debra Safer M.D. , Gail A. Kerver Ph.D. , Leslie A. Laam Ph.D. , Ross D. Crosby Ph.D. , Katherine Nameth B.S. , Leslie J. Heinberg Ph.D. , Dale Bond Ph.D. , Kristine J. Steffen Pharm.D., Ph.D.

Background

There is considerable variability in both the timing of weight change and changes in psychological difficulties functioning following metabolic bariatric surgery (MBS). Empirical studies appear to show that levels of depressive symptoms decrease with weight loss and increase due to weight recurrence. Yet, this research has not included sufficient repeated measurements to account for individual differences in the timing of when weight nadir is achieved and weight recurrence begins post-MBS.

Objectives

Examine how trait-like measures of mood and momentary measures of affect change over time relative to when an individual reach their nadir weight following MBS.

Setting

A health care facility in Sanford Research, Fargo, ND and a university health care facility in Stanford University, Stanford, CA.

Methods

Participants provided data from before surgery until 3 years after surgery. Depressive symptoms (as measured by the Beck Depressive symptoms Inventory) and weight were collected during in-person visits at 6-, 12-, 15-, 18-, 21-, 24-, 30-, and 36-months postsurgery. Momentary mood was assessed via ecologic momentary assessment at 1, 2, and 3 years after surgery.

Results

No difference in BDI scores emerged relative to weight nadir (both before and after nadir). However, there was a statistically-significant positive association between time in months relative to weight nadir and momentary negative affect, but this effect was quite small.

Conclusions

The current study suggests that depressive symptoms does not improve in the time between MBS and weight nadir (i.e., weight loss phase) and also does not deteriorate meaningfully after patients reach their weight nadir (i.e., weight recurrence phase). While momentary negative affect was related to weight change after surgery, this small effect is not likely clinically meaningful.

背景：代谢减肥手术（MBS）后体重变化的时间和心理困难功能的变化都有相当大的可变性。实证研究似乎表明，抑郁症状的水平随着体重减轻而降低，而由于体重复发而增加。然而，这项研究并没有包括足够的重复测量来解释mbs后体重最低点达到和体重复发时间的个体差异。目的：研究情绪的特征测量和情感的瞬间测量是如何随着时间的推移而变化的，相对于个体在MBS后达到最低点的时候。环境：一所位于北达科他州法戈市桑福德研究所的卫生保健机构和一所位于加州斯坦福大学的大学卫生保健机构。方法：参与者提供从术前到术后3年的数据。在术后6个月、12个月、15个月、18个月、21个月、24个月、30个月和36个月的亲自访问中收集抑郁症状（通过贝克抑郁症状量表测量）和体重。术后1年、2年和3年通过生态瞬时评估评估瞬时情绪。结果：BDI评分相对于体重最低点（最低点前后）均无差异。然而，相对于体重最低点的月数与短暂的负面情绪之间存在统计学上显著的正相关，但这种影响相当小。结论：本研究提示，在MBS和体重最低点（即体重减轻期）之间的时间内，抑郁症状没有改善，在患者达到体重最低点（即体重复发期）后，抑郁症状也没有明显恶化。虽然短暂的负面影响与术后体重变化有关，但这种小影响可能没有临床意义。

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引用次数: 0

Comment on “unveiling the cost-effectiveness of bariatric surgery: insights from a matched cohort study” 对“揭示减肥手术的成本效益：来自匹配队列研究的见解”发表评论。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.08.018

Gita Venkata Siva Maruthi Alluri, Koyel Roy, Sunil

引用次数: 0

Comment on: “Achieving optimal nutritional goals in management of patients with sleeve gastrectomy leaks with endoluminal vacuum therapy” 评论：“利用腔内真空治疗实现袖式胃切除术患者渗漏的最佳营养目标”。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.005

Mélissa V. Wills M.D., Matthew Kroh M.D.

引用次数: 0

From weight bias to well-being: the psychophysical impact of body contouring after bariatric surgery 从体重偏见到幸福感：减肥手术后身体轮廓的心理生理影响。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.007

Federica Tomaselli M.D., Roberta Albanese M.D., Damiano Tambasco M.D.

引用次数: 0

Assessing outcomes following magnetic duodenoileal anastomosis with sleeve gastrectomy 十二指肠油膜磁性吻合与袖式胃切除术的疗效评价。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.05.012

Tauheed Akram M.B.Ch.B., Benyamin Alam M.B.Ch.B. (Hons.), Amir Reza Akbari M.B.Ch.B. (Hons.)

引用次数: 0

Effects of bariatric surgery on neurological disturbances and quality of life in patients with metabolic dysfunction-associated steatotic liver disease and obesity: a prospective longitudinal study 减肥手术对代谢功能障碍相关脂肪变性肝病和肥胖患者神经障碍和生活质量的影响：一项前瞻性纵向研究

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.09.012

Concepción Gómez M.D., Ph.D. , Juan José Gallego Roig Ph.D. , María Lapeña M.D. , Clara Alfaro-Cervelló M.D., Ph.D. , Alessandra Fiorillo Ph.D. , Adrià López-Gramaje Ph.D. , Raquel Alfonso Ballester M.D., Ph.D. , Norberto Casinello M.D., Ph.D. , María Capilla Lozano M.D. , María Desamparados Escudero-García M.D., Ph.D. , Cristina Montón M.D., Ph.D. , Amparo Urios Lluch Ph.D. , Juan Antonio Carbonell-Asins Ph.D. , Paloma Lluch M.D., Ph.D. , Carmina Montoliu Félix Ph.D. , María Pilar Ballester M.D., Ph.D.

Background

Neurological impairment has been recognized in up to 70% of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity, which can lead to poor quality of life (QoL).

Objectives

To evaluate the impact of bariatric surgery on neurological alterations, QoL, and factors associated with neurological response.

Setting

Tertiary University Hospital, Spain

Methods

A prospective, longitudinal study was conducted in 53 patients undergoing bariatric surgery between 2021 and 2023. Psychometric tests and the SF-12 questionnaire were performed 1-month before and 3- and 6-months after surgery. Liver biopsy was performed during the intervention. A group of healthy controls was included at a 2:1 ratio, as a reference.

Results

Mean age was 49 (SD 9) years, 68% were female and median body mass index was 45 (interquartile range [IQR] 39-49) kg/m². No patients presented advanced fibrosis (F3-F4) and only 14% showed a nonalcoholic fatty liver disease (NAFLD) score >3 in liver biopsy. A total of 63% exhibited alterations in verbal fluency (Animal Naming Test -ANT-), with a significant improvement at 3- (36%; P = .035) and 6-months (35%; P < .001). Psychomotor speed and selective attention (75% versus 48%; P = .004) as well as bimanual and visuomotor coordination (90% vs. 74%; P = .021) showed a significant improvement after surgery. QoL increased globally, mainly in the physical sphere (P < .001). Older age, diabetes and IL-6 levels were associated with an altered ANT after surgery.

Conclusions

Neurological impairment is common in patients with MASLD and severe obesity. Cognitive, motor performance, and QoL improve after bariatric surgery. Age, diabetes, and inflammatory markers are predictors of poor response.

背景：高达70%的代谢功能障碍相关脂肪变性肝病（MASLD）和肥胖患者存在神经功能障碍，这可能导致生活质量差（QoL）。目的：评估减肥手术对神经改变、生活质量和神经反应相关因素的影响。方法：对2021年至2023年间接受减肥手术的53例患者进行前瞻性、纵向研究。术前1个月、术后3个月和6个月分别进行心理测试和SF-12问卷。干预期间进行肝活检。以2:1的比例纳入一组健康对照作为参考。结果：平均年龄49岁（SD 9），女性占68%，中位体重指数为45（四分位数间距[IQR] 39 ~ 49） kg/m2。没有患者出现晚期纤维化（F3-F4），只有14%的患者在肝活检中显示非酒精性脂肪性肝病（NAFLD）评分为bb0.3。总共有63%的人表现出语言流畅性的改变（动物命名测试- ant -），在3个月（36%,P = 0.035）和6个月（35%,P < 0.001）时有显著改善。精神运动速度和选择性注意（75%对48%，P = 0.004）以及双手和视觉运动协调（90%对74%，P = 0.021）在手术后有显著改善。整体生活质量增加，主要在物理领域（P < 0.001）。老年、糖尿病和IL-6水平与手术后ANT的改变有关。结论：神经功能损害在重度肥胖患者中很常见。减肥手术后认知、运动表现和生活质量得到改善。年龄、糖尿病和炎症标志物是不良反应的预测因子。

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引用次数: 0

Response to comment on “Magnetic duodenoileal anastomosis with sleeve gastrectomy: a prospective multicenter study” by L. Biertho, S. Marceau, M. Nadeau, S. Lebel, F. Julien, A. Tchernof, T. Ransom, R. T. Spence, and J. Ellsmere 对L. Biertho、S. Marceau、M. Nadeau、S. Lebel、F. Julien、a . Tchernof、T. Ransom、R. T. Spence和J. Ellsmere发表的“磁性十二指肠油膜吻合与袖胃切除术：一项前瞻性多中心研究”评论的回应。

IF 3.8 3区医学 Q1 SURGERY

Surgery for Obesity and Related Diseases

Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.010

Laurent Biertho M.D., Simon Marceau M.D., Mélanie Nadeau M.Sc., Stéfane Lebel M.D., François Julien M.D., André Tchernof Ph.D., Thomas Ransom M.D., Richard T. Spence M.D., James Ellsmere M.D.

引用次数: 0

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