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Theories and concepts of physiological mechanisms in metabolic and bariatric surgery, beyond restriction and malabsorption: a narrative review 代谢和减肥手术中生理机制的理论和概念,超越限制和吸收不良:叙述性回顾。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-02-01 Epub Date: 2025-11-08 DOI: 10.1016/j.soard.2025.10.017
Saleha Khan M.D. , Aleena Zobairi M.D. , Sjaak Pouwels M.D., Ph.D. (Mult.) , Alper Celik M.D., Ph.D. , Surendra Ugale M.D., Ph.D. , Chetan Parmar M.B.B.S.
Metabolic and Bariatric surgery (MBS) has become an essential treatment for severe obesity and associated comorbidities, particularly type 2 diabetes mellitus (T2DM), with substantial benefits in weight loss, improved glycemic control, and cardiovascular risk reduction. The International Diabetes Federation (IDF) recognizes MBS as an effective option for individuals with obesity with T2DM due to its ability to improve insulin sensitivity and lower inflammation. These surgeries induce metabolic improvements through distinct mechanisms that affect gut hormone secretion, nutrient absorption, and energy balance. These interventions modulate key gut hormones like glucagon-like peptide-1 (GLP-1), ghrelin, and leptin, which influence appetite, glucose metabolism, and fat storage. Moreover, MBS alters the gut microbiome, contributing to enhanced metabolic function and the resolution of obesity-related conditions. Theories such as the Foregut-Hindgut Hypothesis, Ileal Brake Mechanism, and Gastric Center Hypothesis further try explain these metabolic changes. Understanding these theories and the physiological alterations they provoke is crucial for optimizing patient care and advancing the future of obesity treatments, offering insights into mechanisms that go beyond simple weight loss to address complex metabolic disorders.
代谢和减肥手术(MBS)已成为严重肥胖及相关合并症的基本治疗方法,特别是2型糖尿病(T2DM),在减轻体重、改善血糖控制和降低心血管风险方面具有显著益处。国际糖尿病联合会(IDF)承认MBS是肥胖合并2型糖尿病患者的有效选择,因为它能够改善胰岛素敏感性和降低炎症。这些手术通过影响肠道激素分泌、营养吸收和能量平衡的不同机制诱导代谢改善。这些干预措施调节关键的肠道激素,如胰高血糖素样肽-1 (GLP-1)、胃饥饿素和瘦素,它们影响食欲、葡萄糖代谢和脂肪储存。此外,MBS改变肠道微生物组,有助于增强代谢功能和解决肥胖相关疾病。诸如前-后肠假说、回肠制动机制和胃中枢假说等理论进一步解释了这些代谢变化。了解这些理论及其引发的生理变化对于优化患者护理和推进肥胖治疗的未来至关重要,为解决复杂的代谢紊乱提供了超越简单减肥的机制。
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引用次数: 0
Comment on: effects of bariatric surgery on neurological disturbances and quality of life in patients with MASLD and severe obesity: a prospective longitudinal study 评论:减肥手术对MASLD和重度肥胖患者神经障碍和生活质量的影响:一项前瞻性纵向研究。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-02-01 Epub Date: 2025-11-22 DOI: 10.1016/j.soard.2025.11.020
Mélissa V. Wills M.D., Matthew Kroh M.D.
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引用次数: 0
SOARD Category 1 CME Credit Featured Articles, Volume 22, February 2026 SOARD类别1 CME信贷专题文章,第22卷,2026年2月
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1016/j.soard.2026.01.001
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引用次数: 0
From disability to productivity: the impact of metabolic and bariatric surgery on return to work 从残疾到生产力:代谢和减肥手术对重返工作岗位的影响。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-08-16 DOI: 10.1016/j.soard.2025.08.011
Justin Dhyani M.D. , Samuel Wyman B.S. , Craig Wood M.S. , Arash Rahimi-Ardabily M.D. , Anthony Petrick M.D. , Ryan Horsley D.O.

Background

Limited data exist on employment outcomes following metabolic and bariatric surgery (MBS), and no studies have specifically evaluated outcomes among patients unemployed specifically due to disability at the time of surgery.

Objectives

To assess the impact of MBS on return to work (RTW) among patients who were unemployed due to disability preoperatively.

Setting

Academic medical center in the United States.

Methods

A prospectively maintained MBS database was used to identify patients with known preoperative employment status, age 18-59, who underwent primary MBS between 2006 and 2022. Employment status was extracted from the medical record to identify patients unemployed due to disability. The overall RTW was evaluated using Kaplan–Meier analysis and compared between demographic groups using LogRank tests.

Results

Of the 6534 eligible patients, 9.6% (n = 625) self-reported as not working due to disability during the preoperative period. The rate of self-reported RTW was 10.5%, 17%, 44.3%, at 2, 4, and 10 years respectively. The median follow-up was 5.7 years. Younger age (P = .026) and private insurance (P = .0043) were associated with increased rates of RTW.

Conclusion

More than 40% of patients unemployed due to disability returned to work within 10 years of MBS, with nearly 60% of patients under age 40 returning to work within 10 years. These findings suggest MBS may support long-term functional recovery and socioeconomic reintegration among disabled individuals.
背景:关于代谢和减肥手术(MBS)后就业结果的数据有限,并且没有研究专门评估手术时因残疾而失业的患者的结果。目的:评估MBS对术前因残疾而失业的患者重返工作(RTW)的影响。环境:美国学术医疗中心。方法:一个前瞻性维护的MBS数据库用于识别在2006年至2022年间接受原发性MBS的患者,这些患者术前就业状况已知,年龄在18-59岁之间。从医疗记录中提取就业状况,以确定因残疾而失业的患者。使用Kaplan-Meier分析评估总体RTW,并使用LogRank检验比较人口统计学组间RTW。结果:在6534例符合条件的患者中,9.6% (n = 625)自我报告在术前因残疾而不能工作。在2年、4年和10年时,自我报告的RTW率分别为10.5%、17%、44.3%。中位随访时间为5.7年。年龄较小(P = 0.026)和私人保险(P = 0.0043)与RTW发生率增加有关。结论:超过40%因残疾失业的患者在MBS的10年内重返工作岗位,其中近60%的40岁以下患者在10年内重返工作岗位。这些发现表明MBS可能支持残疾人的长期功能恢复和社会经济重新融入。
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引用次数: 0
Letter to the editor regarding “Impact of high-protein bariatric diet on the prevention of postoperative nausea and vomiting” 关于“高蛋白减肥饮食对预防术后恶心呕吐的影响”的致编辑信。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-08-15 DOI: 10.1016/j.soard.2025.08.007
Leela Kumaran, Sheifali Gupta
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引用次数: 0
Assessment of changes in left ventricular myocardial work using the pressure strain loop after metabolic and bariatric surgery: a prospective nonrandomized cohort study 代谢和减肥手术后使用压力应变环评估左心室心肌功的变化:一项前瞻性非随机队列研究。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-10-10 DOI: 10.1016/j.soard.2025.08.027
Shuai Li M.M. , Yanping Zhang M.M. , Yanxia Zhang M.M. , Jiping Xue M.M. , Chunsong Kang M.M.

Background

Obesity is associated with impaired left ventricular myocardial function. Metabolic and bariatric surgery (MBS) is a potential intervention to improve cardiac function in individuals with obesity.

Objectives

This study aimed to assess changes in left ventricular myocardial work in individuals with obesity following MBS using the pressure-strain loop method, providing a foundation for guiding clinical interventions.

Setting

The study was conducted at a medical facility specializing in MBS and cardiovascular assessments.

Methods

A total of 68 individuals with obesity (mean age 32.9 ± 6.0 years; 32 males) scheduled for MBS were prospectively enrolled, along with 48 healthy volunteers matched for age and sex (mean age 31.6 ± 5.6 years; 22 males) as the control group. Conventional echocardiographic parameters, global longitudinal strain (GLS), and myocardial work (MW) parameters were assessed for all participants both prior to MBS and 12 months postoperatively. MW parameters included global constructive work (GCW), global work index (GWI), global wasted work (GWW), and global work efficiency (GWE).

Results

Twelve months postsurgery, reductions were observed in body mass index (BMI), blood pressure, blood glucose, blood lipids, and left ventricular mass index in the obesity group, although these remained higher than the control group. Improvements were noted in GLS, GCW, GWI, and GWE within the obesity group but remained lower than those of the control group. Conversely, GWW decreased but was still higher than that of the control group.

Conclusions

MBS led to improvements in left ventricular systolic function due to weight reduction and metabolic enhancements; however, these improvements did not fully restore normal levels within 12 months postsurgery.
背景:肥胖与左心室心肌功能受损有关。代谢和减肥手术(MBS)是一种改善肥胖患者心功能的潜在干预措施。目的:本研究旨在利用压力-应变环法评估肥胖患者MBS术后左室心肌功的变化,为指导临床干预提供依据。环境:该研究在一家专门从事MBS和心血管评估的医疗机构进行。方法:前瞻性纳入68例计划进行MBS的肥胖患者(平均年龄32.9±6.0岁,男性32人),以及48名年龄和性别匹配的健康志愿者(平均年龄31.6±5.6岁,男性22人)作为对照组。在MBS术前和术后12个月评估所有参与者的常规超声心动图参数、全局纵向应变(GLS)和心肌功(MW)参数。MW参数包括全局建设功(GCW)、全局工作指数(GWI)、全局浪费功(GWW)和全局工作效率(GWE)。结果:术后12个月,肥胖组的体重指数(BMI)、血压、血糖、血脂和左心室质量指数均有所下降,但仍高于对照组。肥胖组的GLS、GCW、GWI和GWE均有改善,但仍低于对照组。相反,GWW降低,但仍高于对照组。结论:由于体重减轻和代谢增强,MBS可改善左心室收缩功能;然而,这些改善并没有在术后12个月内完全恢复正常水平。
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引用次数: 0
Comment on: “Effects of neoadjuvant glucagon-like-peptide 1 receptor agonists on weight loss after bariatric surgery” 评论:“新辅助胰高血糖素样肽1受体激动剂对减肥手术后体重减轻的影响”。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/j.soard.2025.11.003
Byron Faler M.D., F.A.C.S.
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引用次数: 0
Comment on: “Assessment of changes in left ventricular myocardial work using the pressure strain loop after metabolic and bariatric surgery: a prospective nonrandomized cohort study” 评论:“代谢和减肥手术后使用压力应变环评估左心室心肌功的变化:一项前瞻性非随机队列研究”。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/j.soard.2025.11.004
Mario A. Masrur M.D., Francisco Schlottmann M.D., M.P.H.
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引用次数: 0
Boredom and stress as momentary predictors of loss of control eating after metabolic and bariatric surgery: a longitudinal investigation 无聊和压力作为代谢和减肥手术后饮食失控的瞬间预测因素:一项纵向调查。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-10-10 DOI: 10.1016/j.soard.2025.09.008
Elizabeth N. Dougherty Ph.D. , Matthew F. Murray Ph.D. , Leslie A. Laam Ph.D. , Gail A. Kerver Ph.D. , Taylor B. Stanley M.A. , Afton M. Koball Ph.D. , Kristine J. Steffen Pharm.D., Ph.D. , Leslie J. Heinberg Ph.D. , Debra L. Safer M.D. , Dale S. Bond Ph.D. , Stephen A. Wonderlich Ph.D. , Scott G. Engel Ph.D.

Background

Loss of control eating (LOCE) is associated with adverse clinical outcomes after metabolic and bariatric surgery (MBS); however, current understanding of factors that predict LOCE is incomplete. This study is the first to investigate boredom and stress as predictors of LOCE following MBS.

Objectives

To use ecological momentary assessment (EMA) to evaluate boredom and stress as predictors of LOCE over 3 years following MBS.

Setting

University hospitals; United States.

Methods

Adults (N = 150) who underwent MBS completed a study visit followed by a 1-week EMA protocol at 1-year, 2-year, and 3-years post-MBS (with 143 participants contributing data at year 1, 110 at year 2, and 91 at year 3). During the EMA protocol, participants provided ratings of boredom, stress, and LOCE five times per day.

Results

Stress and boredom were associated with LOCE when controlling for year since surgery. Regarding variability in associations over time, at the within-person level, momentary boredom predicted more severe LOCE, but only at 2 years post-MBS. Momentary stress predicted more severe LOCE at 2- and 3-years post-MBS, with no change between these years. At the between-person level, participants with higher boredom reported more severe LOCE during the EMA protocol at 2- and 3-years post-MBS, with the strongest association 3-years post-MBS. Participants with higher stress reported more severe LOCE during the EMA protocol each year following MBS, with the strongest association at 2-years post-MBS.

Conclusions

Boredom and stress predict more severe LOCE, particularly 2-3 years post-MBS, highlighting this period as an opportunity for intervention.
背景:进食失控(LOCE)与代谢和减肥手术(MBS)后的不良临床结果相关;然而,目前对预测LOCE的因素的理解是不完整的。本研究首次探讨无聊和压力作为MBS后LOCE的预测因子。目的:利用生态瞬时评估(EMA)来评估无聊和压力作为MBS后3年内LOCE的预测因子。地点:大学附属医院;美国。方法:接受MBS的成人(N = 150)完成了一次研究访问,随后在MBS后1年、2年和3年进行了为期1周的EMA方案(其中143名参与者在第1年提供数据,110名在第2年,91名在第3年)。在EMA方案中,参与者每天提供五次无聊、压力和LOCE评分。结果:术后1年内,压力和无聊与LOCE相关。关于随时间变化的相关性,在人的层面上,短暂的无聊预示着更严重的LOCE,但仅在mbs后2年。瞬时压力预示着mbs后2年和3年更严重的LOCE,这几年之间没有变化。在人与人之间的水平上,在mbs后2年和3年的EMA方案中,无聊程度较高的参与者报告了更严重的LOCE,其中mbs后3年的相关性最强。在MBS后每年的EMA方案中,压力较高的参与者报告了更严重的LOCE,在MBS后2年的相关性最强。结论:无聊和压力预示着更严重的LOCE,特别是在mbs后的2-3年,这一时期是干预的机会。
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引用次数: 0
Comment on: kidney transplantation after bariatric surgery – outcomes from a 30-year experience 评论:30年经验的减肥手术后肾移植。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.soard.2025.11.014
Nicole L. Petcka M.D., Elizabeth M. Hechenbleikner M.D.
{"title":"Comment on: kidney transplantation after bariatric surgery – outcomes from a 30-year experience","authors":"Nicole L. Petcka M.D.,&nbsp;Elizabeth M. Hechenbleikner M.D.","doi":"10.1016/j.soard.2025.11.014","DOIUrl":"10.1016/j.soard.2025.11.014","url":null,"abstract":"","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 65-66"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Surgery for Obesity and Related Diseases
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