Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.11.010
Laurent Biertho M.D., Simon Marceau M.D., Mélanie Nadeau M.Sc., Stéfane Lebel M.D., François Julien M.D., André Tchernof Ph.D., Thomas Ransom M.D., Richard T. Spence M.D., James Ellsmere M.D.
{"title":"Response to comment on “Magnetic duodenoileal anastomosis with sleeve gastrectomy: a prospective multicenter study” by L. Biertho, S. Marceau, M. Nadeau, S. Lebel, F. Julien, A. Tchernof, T. Ransom, R. T. Spence, and J. Ellsmere","authors":"Laurent Biertho M.D., Simon Marceau M.D., Mélanie Nadeau M.Sc., Stéfane Lebel M.D., François Julien M.D., André Tchernof Ph.D., Thomas Ransom M.D., Richard T. Spence M.D., James Ellsmere M.D.","doi":"10.1016/j.soard.2025.11.010","DOIUrl":"10.1016/j.soard.2025.11.010","url":null,"abstract":"","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 179-180"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Evaluation of patients on immunosuppressants undergoing sleeve gastrectomy, Roux-en-Y gastric bypass, and duodenal switch: analysis of 19,414 patients”","authors":"Prajnasini Satapathy M.D., Rachana Mehta M.Sc., Ranjana Sah M.D.","doi":"10.1016/j.soard.2025.08.005","DOIUrl":"10.1016/j.soard.2025.08.005","url":null,"abstract":"","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 182-183"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.08.025
Lucas Friedrich Fontoura M.D., Ph.D. , Lucas S. Matzenbacher M.D. , Laura Gomes Boabaid de Barros , Ana Gabriela Rodrigues Haussen , Mariana Kude Perrone , Vicenzo Gheno , Helena Toniazzi Uchôa , Andres Di Leoni Ferrari M.D., Ph.D. , Claudio Cora Mottin M.D., Ph.D. , Alexandre Vontobel Padoin M.D., Ph.D. , Janine Alessi M.D., Ph.D. , Gabriela Heiden Telo M.D., Ph.D.
Background
Excess weight has been linked to leftward QRS axis deviation, but the impact of significant weight loss on cardiac axis remains unclear.
Objectives
To evaluate the association between excess weight loss following bariatric surgery and changes in the electrocardiographic cardiac axis.
Setting
Single academic medical center in Brazil.
Methods
Retrospective cohort including patients who underwent bariatric surgery at a multidisciplinary obesity treatment center in Southern Brazil. Pre- and postoperative electrocardiographies (ECGs) were analyzed, with exact cardiac axis determined using the Novosel equation. The main outcome was the association between the percentage of excess weight loss (EWL%) and the change in cardiac axis (Δθa), defined as the difference between the pre- and postoperative cardiac axis values. Multivariable linear regression models were applied, adjusting for time since bariatric surgery.
Results
A total of 60 participants (mean age of 42.15 years, 68.3% female) were included. The mean preoperative body mass index was 42.9 ± 6.2 kg/m2, decreasing to 28.9 ± 5.2 kg/m2 postoperatively, with an average EWL% of 66.7 ± 16%. The mean cardiac axis shifted from 27.99 ± 30.77 degrees preoperatively to 42.37 ± 34.06 degrees postoperatively (Δθa = 14.38 ± 26.61 degrees). A 1% increase in EWL% was associated with a .44-degree increase in the cardiac axis (B = .44; 95% confidence interval [CI]: .15–.80; P = .009).
Conclusions
Weight loss following bariatric surgery is associated with changes in the electrocardiographic cardiac axis, with a trend toward rightward shifts. The clinical significance of these findings remains uncertain, and further studies are needed to confirm and clarify the prognostic value of these electrocardiographic adaptations.
{"title":"Association between cardiac axis changes and excess weight loss following bariatric surgery","authors":"Lucas Friedrich Fontoura M.D., Ph.D. , Lucas S. Matzenbacher M.D. , Laura Gomes Boabaid de Barros , Ana Gabriela Rodrigues Haussen , Mariana Kude Perrone , Vicenzo Gheno , Helena Toniazzi Uchôa , Andres Di Leoni Ferrari M.D., Ph.D. , Claudio Cora Mottin M.D., Ph.D. , Alexandre Vontobel Padoin M.D., Ph.D. , Janine Alessi M.D., Ph.D. , Gabriela Heiden Telo M.D., Ph.D.","doi":"10.1016/j.soard.2025.08.025","DOIUrl":"10.1016/j.soard.2025.08.025","url":null,"abstract":"<div><h3>Background</h3><div>Excess weight has been linked to leftward QRS axis deviation, but the impact of significant weight loss on cardiac axis remains unclear.</div></div><div><h3>Objectives</h3><div>To evaluate the association between excess weight loss following bariatric surgery and changes in the electrocardiographic cardiac axis.</div></div><div><h3>Setting</h3><div>Single academic medical center in Brazil.</div></div><div><h3>Methods</h3><div>Retrospective cohort including patients who underwent bariatric surgery at a multidisciplinary obesity treatment center in Southern Brazil. Pre- and postoperative electrocardiographies (ECGs) were analyzed, with exact cardiac axis determined using the Novosel equation. The main outcome was the association between the percentage of excess weight loss (EWL%) and the change in cardiac axis (Δθ<sub>a</sub>), defined as the difference between the pre- and postoperative cardiac axis values. Multivariable linear regression models were applied, adjusting for time since bariatric surgery.</div></div><div><h3>Results</h3><div>A total of 60 participants (mean age of 42.15 years, 68.3% female) were included. The mean preoperative body mass index was 42.9 ± 6.2 kg/m<sup>2</sup>, decreasing to 28.9 ± 5.2 kg/m<sup>2</sup> postoperatively, with an average EWL% of 66.7 ± 16%. The mean cardiac axis shifted from 27.99 ± 30.77 degrees preoperatively to 42.37 ± 34.06 degrees postoperatively (Δθ<sub>a</sub> = 14.38 ± 26.61 degrees). A 1% increase in EWL% was associated with a .44-degree increase in the cardiac axis (B = .44; 95% confidence interval [CI]: .15–.80; <em>P</em> = .009).</div></div><div><h3>Conclusions</h3><div>Weight loss following bariatric surgery is associated with changes in the electrocardiographic cardiac axis, with a trend toward rightward shifts. The clinical significance of these findings remains uncertain, and further studies are needed to confirm and clarify the prognostic value of these electrocardiographic adaptations.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 84-91"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.09.005
Abraham J. Matar M.D. , M. Caner Aydin M.D. , Daniel Waller M.S. , Erika Helgeson Ph.D. , David Vock Ph.D. , Matthew Wright M.D. , Karthik Ramanathan M.D. , Vanessa Humphreville M.D. , Erik B. Finger M.D., Ph.D. , Timothy Pruett M.D. , Arthur J. Matas M.D. , Eric Wise M.D. , Sayeed Ikramuddin M.D. , Raja Kandaswamy M.D. , Daniel B. Leslie M.D.
Background
The clinical impact of metabolic and bariatric surgery (MBS) before kidney transplantation (KTx) is evolving.
Methods
This was a single-center retrospective study of all adult patients between January 1, 1994, and December 31, 2024, undergoing KTx with a history of antecedent MBS. Primary outcomes included death-censored graft survival and overall patient survival.
Results
Among 4538 KTx recipients, 116 (2.6%) had a history of previous MBS. Median time (interquartile range, range) between BS and KTx was 6.8 years (10.9, .3–45.5). Of these, patients underwent Roux-en-Y gastric bypass (RYGB, n = 77, 66.4%), vertical sleeve gastrectomy (VSG, n = 23, 19.8%), gastric banding (n = 6, 5.2%), vertical banded gastroplasty (n = 5, 4.3%), jejunoileal bypass (n = 3, 2.6%), and duodenal switch (n = 2, 1.7%). The type of MBS (VSG versus RYGB) did not impact long-term outcomes. In total, 28 (24.1%) patients underwent planned BS with the specific intention of reaching an acceptable body mass index (BMI) threshold for KTx. Median time between BS and KTx for these patients was 1.1 years (1.3, .3–4.7). Nine patients underwent RYGB, and 19 underwent VSG. Median BMI (IQR) was reduced from 43.8 kg/m2 (6.9) at time of MBS to 32.1 kg/m2 (7.3) at time of KTx. One-year overall survival and death-censored graft survival were 96.4% and 100%, respectively. At median follow-up of 2.7 years, overall survival and death-censored graft survival were 85.7% and 89.3%. A propensity matched analysis revealed no differences in the rates of surgical complications after KTx among those with BS compared to matched controls without MBS.
Conclusions
This study represents the largest single-center series of patients with MBS before KTx. Timing of antecedent BS and type of BS did not impact long-term graft or patient outcomes. Planned MBS with either VSG or RYGB followed by KTx in patients with an initially prohibitive BMI is associated with excellent short- and medium-term outcomes.
背景:肾移植(KTx)前代谢和减肥手术(MBS)的临床影响正在不断发展。方法:这是一项单中心回顾性研究,研究对象为1994年1月1日至2024年12月31日期间接受KTx治疗且既往有MBS病史的所有成年患者。主要结局包括死亡剔除的移植物生存和患者总生存。结果:在4538名KTx接受者中,116名(2.6%)有既往MBS病史。BS和KTx的中位时间(四分位数间距,范围)为6.8年(10.9,0.3 -45.5)。其中,患者接受Roux-en-Y胃旁路术(RYGB, n = 77, 66.4%)、垂直袖胃切除术(VSG, n = 23, 19.8%)、胃束带术(n = 6, 5.2%)、垂直束带胃成形术(n = 5, 4.3%)、空肠回肠旁路术(n = 3, 2.6%)和十二指肠切换术(n = 2, 1.7%)。MBS类型(VSG vs RYGB)对长期预后没有影响。总共有28例(24.1%)患者接受了有计划的BS,其具体目的是达到可接受的KTx体重指数(BMI)阈值。这些患者BS和KTx之间的中位时间为1.1年(1.3年,0.3 -4.7年)。RYGB 9例,VSG 19例。中位BMI (IQR)从MBS时的43.8 kg/m2(6.9)降至KTx时的32.1 kg/m2(7.3)。一年总生存率为96.4%,移植瘤死亡后生存率为100%。中位随访2.7年,总生存率和死亡后移植生存率分别为85.7%和89.3%。倾向匹配分析显示,与没有MBS的对照组相比,BS患者在KTx后的手术并发症发生率没有差异。结论:该研究代表了KTx前MBS患者最大的单中心系列研究。先前BS的时间和BS的类型对移植或患者的长期预后没有影响。在最初BMI过高的患者中,VSG或RYGB合并KTx的计划MBS与良好的中短期预后相关。
{"title":"Kidney transplantation after bariatric surgery—Outcomes from a 30-year experience","authors":"Abraham J. Matar M.D. , M. Caner Aydin M.D. , Daniel Waller M.S. , Erika Helgeson Ph.D. , David Vock Ph.D. , Matthew Wright M.D. , Karthik Ramanathan M.D. , Vanessa Humphreville M.D. , Erik B. Finger M.D., Ph.D. , Timothy Pruett M.D. , Arthur J. Matas M.D. , Eric Wise M.D. , Sayeed Ikramuddin M.D. , Raja Kandaswamy M.D. , Daniel B. Leslie M.D.","doi":"10.1016/j.soard.2025.09.005","DOIUrl":"10.1016/j.soard.2025.09.005","url":null,"abstract":"<div><h3>Background</h3><div>The clinical impact of metabolic and bariatric surgery (MBS) before kidney transplantation (KTx) is evolving.</div></div><div><h3>Methods</h3><div>This was a single-center retrospective study of all adult patients between January 1, 1994, and December 31, 2024, undergoing KTx with a history of antecedent MBS. Primary outcomes included death-censored graft survival and overall patient survival.</div></div><div><h3>Results</h3><div>Among 4538 KTx recipients, 116 (2.6%) had a history of previous MBS. Median time (interquartile range, range) between BS and KTx was 6.8 years (10.9, .3–45.5). Of these, patients underwent Roux-en-Y gastric bypass (RYGB, n = 77, 66.4%), vertical sleeve gastrectomy (VSG, n = 23, 19.8%), gastric banding (n = 6, 5.2%), vertical banded gastroplasty (n = 5, 4.3%), jejunoileal bypass (n = 3, 2.6%), and duodenal switch (n = 2, 1.7%). The type of MBS (VSG versus RYGB) did not impact long-term outcomes. In total, 28 (24.1%) patients underwent planned BS with the specific intention of reaching an acceptable body mass index (BMI) threshold for KTx. Median time between BS and KTx for these patients was 1.1 years (1.3, .3–4.7). Nine patients underwent RYGB, and 19 underwent VSG. Median BMI (IQR) was reduced from 43.8 kg/m<sup>2</sup> (6.9) at time of MBS to 32.1 kg/m<sup>2</sup> (7.3) at time of KTx. One-year overall survival and death-censored graft survival were 96.4% and 100%, respectively. At median follow-up of 2.7 years, overall survival and death-censored graft survival were 85.7% and 89.3%. A propensity matched analysis revealed no differences in the rates of surgical complications after KTx among those with BS compared to matched controls without MBS.</div></div><div><h3>Conclusions</h3><div>This study represents the largest single-center series of patients with MBS before KTx. Timing of antecedent BS and type of BS did not impact long-term graft or patient outcomes. Planned MBS with either VSG or RYGB followed by KTx in patients with an initially prohibitive BMI is associated with excellent short- and medium-term outcomes.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 57-65"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.09.009
Ryan J. Marek Ph.D , Valentina Ivezaj Ph.D , Manish S. Parikh M.S , Maansi Jayade B.S , Jessica Lawson Ph.D , Carlos M. Grilo Ph.D
Background
Eating disorders are routinely assessed for in persons seeking metabolic and bariatric surgery (MBS). One construct in particular, loss-of-control over eating, appears to be important to understanding clinical needs and outcomes in MBS. The Eating Loss of Control Scale (ELOCS) has received some initial validation for use in MBS settings, but its factor structure remains uncertain and its performance about diverse groups is unknown.
Objectives
The purpose of this study is to explore further the psychometric properties and factor structure of ELOCS in Hispanic persons seeking MBS and to establish measurement invariance between the English- and Spanish-language version.
Setting
Academic Medical Center
Methods
Participants (n = 618) undergoing evaluations prior to bariatric surgery who identified as Hispanic and consented to participate in this research study completed self-report measures of eating disorders and loss of control over eating. Of the 618 participants, a total of 318 persons preferred English and were administered English versions of the measures and 300 persons preferred Spanish and were administered Spanish versions of the measures.
Results
Factor analyses supported a one-factor, 18-item ELOCS (after removal of 2 original items 6 and 20), though Comparative Fit Index (CFI) was slightly below conventional cut-offs and RMESA were mediocre. The measure was also invariant across language translations. The 18-item ELOCS had good internal consistency (α = .97), though the internal consistency suggests that there is still considerable redundancy on the measure. The ELOCS-18 also demonstrated good convergent and discriminant validity with an established eating disorder measure.
Conclusions
The 18-item ELOCS is a reliable and valid measure to use in MBS settings, though factor analyses suggest further psychometric work is warranted. A Spanish-translated version assesses the construct of LOC similarly to its English counterpart. Due to some below threshold indices, the ELOCS factor structure should be further studied.
{"title":"Psychometric properties of the Eating loss of control scale in a sample of Hispanic persons seeking metabolic and bariatric surgery","authors":"Ryan J. Marek Ph.D , Valentina Ivezaj Ph.D , Manish S. Parikh M.S , Maansi Jayade B.S , Jessica Lawson Ph.D , Carlos M. Grilo Ph.D","doi":"10.1016/j.soard.2025.09.009","DOIUrl":"10.1016/j.soard.2025.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Eating disorders are routinely assessed for in persons seeking metabolic and bariatric surgery (MBS). One construct in particular, loss-of-control over eating, appears to be important to understanding clinical needs and outcomes in MBS. The Eating Loss of Control Scale (ELOCS) has received some initial validation for use in MBS settings, but its factor structure remains uncertain and its performance about diverse groups is unknown.</div></div><div><h3>Objectives</h3><div>The purpose of this study is to explore further the psychometric properties and factor structure of ELOCS in Hispanic persons seeking MBS and to establish measurement invariance between the English- and Spanish-language version.</div></div><div><h3>Setting</h3><div>Academic Medical Center</div></div><div><h3>Methods</h3><div>Participants (n = 618) undergoing evaluations prior to bariatric surgery who identified as Hispanic and consented to participate in this research study completed self-report measures of eating disorders and loss of control over eating. Of the 618 participants, a total of 318 persons preferred English and were administered English versions of the measures and 300 persons preferred Spanish and were administered Spanish versions of the measures.</div></div><div><h3>Results</h3><div>Factor analyses supported a one-factor, 18-item ELOCS (after removal of 2 original items 6 and 20), though Comparative Fit Index (CFI) was slightly below conventional cut-offs and RMESA were mediocre. The measure was also invariant across language translations. The 18-item ELOCS had good internal consistency (α = .97), though the internal consistency suggests that there is still considerable redundancy on the measure. The ELOCS-18 also demonstrated good convergent and discriminant validity with an established eating disorder measure.</div></div><div><h3>Conclusions</h3><div>The 18-item ELOCS is a reliable and valid measure to use in MBS settings, though factor analyses suggest further psychometric work is warranted. A Spanish-translated version assesses the construct of LOC similarly to its English counterpart. Due to some below threshold indices, the ELOCS factor structure should be further studied.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 99-105"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.09.010
Maria Charina Benavidez M.D., Sophia Redpath B.A., Stephanie Trautmann M.D., Santiago Ceron M.D, Scott Schimpke M.D., Jonathan Myers M.D., Philip Omotosho M.D., Alfonso Torquati M.D., Nicholas J. Skertich M.D.
Background
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prevalent medications used to treat patients with obesity. While bariatric surgery remains the most successful single intervention, many surgical patients have been on a GLP-1RA.
Objectives
This study aims to determine if the neoadjuvant use of GLP-1RA affects surgical weight loss.
Setting
University Hospital, United States.
Methods
This retrospective cohort study compared outcomes of patients undergoing sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) who were treated preoperatively with and without GLP-1RAs from July 2022 to June 2023. T-tests and multivariable analyses were utilized to determine significant differences in weight loss.
Results
Of 422 patients, 36 (8.5%) received neoadjuvant GLP-1RAs and 386 (91.5%) did not. Mean preoperative body mass index (BMI) was 47 for both groups. Median time for GLP1-RAs was 12 months prior to bariatric surgery but not resumed after. There was a significant difference between patients who received neoadjuvant GLP1-RAs versus those who did not at 2 weeks (mean change in BMI of −4.9 vs −3.8, P = .006), but not at 3- (−9 vs −8.4, P = .25), 6- (−12.4 vs −11.2, P = .13), or 12 months (−14.2 [n = 21] vs −12.9 [n = 249], P = .25) postoperatively. Multivariable analysis showed no difference in weight loss at any time point when adjusting for operation type.
Conclusions
Although neoadjuvant GLP-1RAs did not significantly impact weight loss after bariatric surgery, there was an additive weight loss effect.
背景:胰高血糖素样肽-1受体激动剂(GLP-1RAs)越来越普遍用于治疗肥胖患者。虽然减肥手术仍然是最成功的单一干预措施,但许多手术患者已经使用了GLP-1RA。目的:本研究旨在确定GLP-1RA的新辅助使用是否影响手术减肥。地点:美国大学医院。方法:本回顾性队列研究比较了2022年7月至2023年6月术前接受GLP-1RAs治疗和不接受GLP-1RAs治疗的袖式胃切除术(SG)或Roux-en-Y胃旁路术(RYGB)患者的结果。使用t检验和多变量分析来确定体重减轻的显著差异。结果:422例患者中,36例(8.5%)接受新辅助GLP-1RAs治疗,386例(91.5%)未接受新辅助GLP-1RAs治疗。两组术前平均体重指数(BMI)均为47。减肥手术前GLP1-RAs的中位时间为12个月,但手术后没有恢复。接受新辅助GLP1-RAs治疗的患者与未接受新辅助GLP1-RAs治疗的患者在术后2周(BMI平均变化为-4.9 vs -3.8, P = 0.006),但在术后3个月(-9 vs -8.4, P = 0.25)、6个月(-12.4 vs -11.2, P = 0.13)或12个月(-14.2 [n = 21] vs -12.9 [n = 249], P = 0.25)时差异无统计学意义。多变量分析显示,在调整手术类型后,任何时间点的体重减轻均无差异。结论:虽然新辅助GLP-1RAs对减肥手术后的体重减轻没有显著影响,但存在附加的体重减轻作用。
{"title":"Effects of neoadjuvant glucagon-like-peptide 1 receptor agonists on weight loss after bariatric surgery","authors":"Maria Charina Benavidez M.D., Sophia Redpath B.A., Stephanie Trautmann M.D., Santiago Ceron M.D, Scott Schimpke M.D., Jonathan Myers M.D., Philip Omotosho M.D., Alfonso Torquati M.D., Nicholas J. Skertich M.D.","doi":"10.1016/j.soard.2025.09.010","DOIUrl":"10.1016/j.soard.2025.09.010","url":null,"abstract":"<div><h3>Background</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prevalent medications used to treat patients with obesity. While bariatric surgery remains the most successful single intervention, many surgical patients have been on a GLP-1RA.</div></div><div><h3>Objectives</h3><div>This study aims to determine if the neoadjuvant use of GLP-1RA affects surgical weight loss.</div></div><div><h3>Setting</h3><div>University Hospital, United States.</div></div><div><h3>Methods</h3><div>This retrospective cohort study compared outcomes of patients undergoing sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) who were treated preoperatively with and without GLP-1RAs from July 2022 to June 2023. T-tests and multivariable analyses were utilized to determine significant differences in weight loss.</div></div><div><h3>Results</h3><div>Of 422 patients, 36 (8.5%) received neoadjuvant GLP-1RAs and 386 (91.5%) did not. Mean preoperative body mass index (BMI) was 47 for both groups. Median time for GLP1-RAs was 12 months prior to bariatric surgery but not resumed after. There was a significant difference between patients who received neoadjuvant GLP1-RAs versus those who did not at 2 weeks (mean change in BMI of −4.9 vs −3.8, <em>P</em> = .006), but not at 3- (−9 vs −8.4, <em>P</em> = .25), 6- (−12.4 vs −11.2, <em>P</em> = .13), or 12 months (−14.2 [n = 21] vs −12.9 [n = 249], <em>P</em> = .25) postoperatively. Multivariable analysis showed no difference in weight loss at any time point when adjusting for operation type.</div></div><div><h3>Conclusions</h3><div>Although neoadjuvant GLP-1RAs did not significantly impact weight loss after bariatric surgery, there was an additive weight loss effect.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 18-23"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145403475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.11.002
Rodolfo J. Oviedo M.D., F.A.C.S., F.R.C.S., F.I.C.S., F.A.S.M.B.S., D.A.B.S.-F.P.D.M.B.S.
{"title":"Comment on: “Assessment of changes in left ventricular myocardial work using the pressure strain loop after metabolic and bariatric surgery: a prospective nonrandomized cohort study”","authors":"Rodolfo J. Oviedo M.D., F.A.C.S., F.R.C.S., F.I.C.S., F.A.S.M.B.S., D.A.B.S.-F.P.D.M.B.S.","doi":"10.1016/j.soard.2025.11.002","DOIUrl":"10.1016/j.soard.2025.11.002","url":null,"abstract":"","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 37-38"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.09.003
Baraa Saad M.B.B.S. , Kenan Rahima M.B.B.S. , Mohammed M. Mourad B.Sc. , Dilip K. Vankayalapati M.B.B.S. , Omotayo Segun-Omosehin B.Sc. , Hafsa O. Sulaiman M.D. , James W.F. Burns M.B.B.S. , Hayato Nakanishi M.B.B.S., M.S. , Christian A. Than M.B.B.S., Ph.D. , Akheel A. Syed M.B.B.S., Ph.D., F.R.C.P.E. , Bilal Alkhaffaf M.B.Ch.B., Ph.D., F.R.C.S.
Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited. This systematic review and meta-analysis evaluates the safety and efficacy of RYGB in adolescents with obesity. A comprehensive literature search was conducted across databases, including MEDLINE, EMBASE, Cochrane, and SCOPUS up to July 2023. Included studies reported outcomes for participants younger than 21 years of age undergoing RYGB, with a minimum follow-up of 2 years. A random-effects model was used for pooled analysis. Twelve studies were included involving 522 adolescents. The mean age was 17.5 years (13-21 years), 73.6% of patients were female, and the mean follow-up was 48.4 months. Baseline body mass index (BMI) was 50.1 kg/m2. BMI reduction peaked at 1 year with an absolute reduction of 19.1 kg/m2, 36.6% total loss, and 67.7% excess BMI loss. At 5 years, absolute reduction of BMI was 19.1 kg/m2, percentage loss was 31.5%, and excess BMI loss was 70.5%. Comorbidity remission rates were 85% for dyslipidemia, 73% for hypertension, 85% for type 2 diabetes, and 68% for obstructive sleep apnea. Iron and vitamin B12 deficiency rates were greater postoperatively. The complication rate was 29.1%. RYGB in adolescents leads to significant weight loss and comorbidity resolution but carries risk of complications and requires monitoring for nutritional deficiencies. Further long-term studies are essential.
{"title":"Long-term outcomes of Roux-en-Y gastric bypass in the adolescent population: a systematic review and single-arm meta-analysis","authors":"Baraa Saad M.B.B.S. , Kenan Rahima M.B.B.S. , Mohammed M. Mourad B.Sc. , Dilip K. Vankayalapati M.B.B.S. , Omotayo Segun-Omosehin B.Sc. , Hafsa O. Sulaiman M.D. , James W.F. Burns M.B.B.S. , Hayato Nakanishi M.B.B.S., M.S. , Christian A. Than M.B.B.S., Ph.D. , Akheel A. Syed M.B.B.S., Ph.D., F.R.C.P.E. , Bilal Alkhaffaf M.B.Ch.B., Ph.D., F.R.C.S.","doi":"10.1016/j.soard.2025.09.003","DOIUrl":"10.1016/j.soard.2025.09.003","url":null,"abstract":"<div><div>Long-term outcomes of Roux-en-Y gastric bypass (RYGB) in adolescents are limited. This systematic review and meta-analysis evaluates the safety and efficacy of RYGB in adolescents with obesity. A comprehensive literature search was conducted across databases, including MEDLINE, EMBASE, Cochrane, and SCOPUS up to July 2023. Included studies reported outcomes for participants younger than 21 years of age undergoing RYGB, with a minimum follow-up of 2 years. A random-effects model was used for pooled analysis. Twelve studies were included involving 522 adolescents. The mean age was 17.5 years (13-21 years), 73.6% of patients were female, and the mean follow-up was 48.4 months. Baseline body mass index (BMI) was 50.1 kg/m<sup>2</sup>. BMI reduction peaked at 1 year with an absolute reduction of 19.1 kg/m<sup>2</sup>, 36.6% total loss, and 67.7% excess BMI loss. At 5 years, absolute reduction of BMI was 19.1 kg/m<sup>2</sup>, percentage loss was 31.5%, and excess BMI loss was 70.5%. Comorbidity remission rates were 85% for dyslipidemia, 73% for hypertension, 85% for type 2 diabetes, and 68% for obstructive sleep apnea. Iron and vitamin B12 deficiency rates were greater postoperatively. The complication rate was 29.1%. RYGB in adolescents leads to significant weight loss and comorbidity resolution but carries risk of complications and requires monitoring for nutritional deficiencies. Further long-term studies are essential.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 164-177"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The management of individuals receiving chronic anticoagulation (CAC) who are undergoing bariatric surgery presents a complex challenge, because there is a delicate balance between risks of perioperative bleeding and thromboembolic events.
Objectives
To evaluate and compare rates of bleeding, thrombotic events, and overall outcomes of patients on CAC undergoing bariatric surgery.
Setting
United States.
Methods
Data spanning 2020 to 2021 were extracted from the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database, with a focus on patients who underwent primary minimally invasive bariatric surgery. A multivariable regression analysis examined 30-day outcomes for patients anticoagulated preoperatively. In addition, a propensity-matched analysis was performed comparing outcomes among patients on CAC and those without.
Results
In total 331,201 patients were analyzed, with 8428 (2.5%) receiving CAC. Propensity score matching revealed that patients on CAC exhibited greater rates of reoperations within 30 days (1.9% versus 1.3%, P < .001), overall readmissions after 30 days (7.2% versus 3.3% respectively, P < .0001), and reinterventions within 30 days (1.6% versus .9%, P < .0001) compared with patients not on preoperative CAC. Transfusion intra/postoperative and postoperative gastrointestinal tract bleeding events were elevated in the preoperative therapeutic anticoagulant group (2.2% versus .8%, P < .0001 and 1.4% versus .3%, P < .0001, respectively) compared with no preoperative CAC group.
Conclusions
Patients undergoing bariatric surgery while on preoperative CAC face significantly increased risks of adverse postoperative outcomes. Individuals requiring long-term anticoagulation should undergo careful consideration before proceeding with bariatric surgery.
背景:接受慢性抗凝治疗(CAC)的减肥手术患者的管理是一个复杂的挑战,因为围手术期出血和血栓栓塞事件的风险之间存在微妙的平衡。目的:评估和比较接受减肥手术的CAC患者的出血、血栓形成事件和总体结果。背景:美国。方法:从代谢和减肥手术认证和质量改进计划数据库中提取2020年至2021年的数据,重点关注接受初级微创减肥手术的患者。多变量回归分析检查了术前抗凝患者30天的预后。此外,进行了倾向匹配分析,比较了CAC患者和未CAC患者的结果。结果:共分析了331,201例患者,其中8428例(2.5%)接受了CAC。倾向评分匹配显示,CAC患者在30天内的再手术率(1.9%对1.3%,P < .001)、30天后的总体再入院率(7.2%对3.3%,P < .0001)和30天内的再干预率(1.6%对。9%, P < 0.0001),与术前未行CAC的患者相比。在术前抗凝治疗组中,输血、术后和术后胃肠道出血事件均升高(2.2% vs .2%)。8%, P < 0.0001, 1.4%。3%, P < 0.0001),与术前无CAC组比较。结论:术前行CAC的减肥手术患者术后不良预后的风险显著增加。需要长期抗凝治疗的个体在进行减肥手术前应仔细考虑。
{"title":"Impact of chronic anticoagulation on perioperative outcomes in patients undergoing minimally invasive bariatric surgery—Propensity score–matched analysis using the 2020–2021 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program","authors":"Elad Boaz M.D. , Pauline Aeschbacher M.D. , Noam Kahana M.D. , Nir Horesh M.D. , Emanuele Lo Menzo M.D. Ph.D., F.A.C.S. , Samuel Szomstein M.D., F.A.C.S., F.A.S.M.B.S. , Raul J. Rosenthal M.D., F.A.C.S., F.A.S.M.B.S.","doi":"10.1016/j.soard.2025.09.004","DOIUrl":"10.1016/j.soard.2025.09.004","url":null,"abstract":"<div><h3>Background</h3><div>The management of individuals receiving chronic anticoagulation (CAC) who are undergoing bariatric surgery presents a complex challenge, because there is a delicate balance between risks of perioperative bleeding and thromboembolic events.</div></div><div><h3>Objectives</h3><div>To evaluate and compare rates of bleeding, thrombotic events, and overall outcomes of patients on CAC undergoing bariatric surgery.</div></div><div><h3>Setting</h3><div>United States.</div></div><div><h3>Methods</h3><div>Data spanning 2020 to 2021 were extracted from the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database, with a focus on patients who underwent primary minimally invasive bariatric surgery. A multivariable regression analysis examined 30-day outcomes for patients anticoagulated preoperatively. In addition, a propensity-matched analysis was performed comparing outcomes among patients on CAC and those without.</div></div><div><h3>Results</h3><div>In total 331,201 patients were analyzed, with 8428 (2.5%) receiving CAC. Propensity score matching revealed that patients on CAC exhibited greater rates of reoperations within 30 days (1.9% versus 1.3%, <em>P</em> < .001), overall readmissions after 30 days (7.2% versus 3.3% respectively, <em>P</em> < .0001), and reinterventions within 30 days (1.6% versus .9%, <em>P</em> < .0001) compared with patients not on preoperative CAC. Transfusion intra/postoperative and postoperative gastrointestinal tract bleeding events were elevated in the preoperative therapeutic anticoagulant group (2.2% versus .8%, <em>P</em> < .0001 and 1.4% versus .3%, <em>P</em> < .0001, respectively) compared with no preoperative CAC group.</div></div><div><h3>Conclusions</h3><div>Patients undergoing bariatric surgery while on preoperative CAC face significantly increased risks of adverse postoperative outcomes. Individuals requiring long-term anticoagulation should undergo careful consideration before proceeding with bariatric surgery.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 49-55"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.soard.2025.11.012
Kamal Abi Mosleh M.D., Hugh Babineau M.D.
{"title":"Comment on: “impact of chronic anticoagulation on perioperative outcomes in patients undergoing minimally invasive bariatric surgery - propensity score matched analysis using the 2020-2021 MBSAQIP”","authors":"Kamal Abi Mosleh M.D., Hugh Babineau M.D.","doi":"10.1016/j.soard.2025.11.012","DOIUrl":"10.1016/j.soard.2025.11.012","url":null,"abstract":"","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 55-56"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}