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From weight bias to well-being: the psychophysical impact of body contouring after bariatric surgery 从体重偏见到幸福感:减肥手术后身体轮廓的心理生理影响。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.007
Federica Tomaselli M.D., Roberta Albanese M.D., Damiano Tambasco M.D.
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引用次数: 0
Assessing outcomes following magnetic duodenoileal anastomosis with sleeve gastrectomy 十二指肠油膜磁性吻合与袖式胃切除术的疗效评价。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.05.012
Tauheed Akram M.B.Ch.B., Benyamin Alam M.B.Ch.B. (Hons.), Amir Reza Akbari M.B.Ch.B. (Hons.)
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引用次数: 0
Effects of bariatric surgery on neurological disturbances and quality of life in patients with metabolic dysfunction-associated steatotic liver disease and obesity: a prospective longitudinal study 减肥手术对代谢功能障碍相关脂肪变性肝病和肥胖患者神经障碍和生活质量的影响:一项前瞻性纵向研究
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.09.012
Concepción Gómez M.D., Ph.D. , Juan José Gallego Roig Ph.D. , María Lapeña M.D. , Clara Alfaro-Cervelló M.D., Ph.D. , Alessandra Fiorillo Ph.D. , Adrià López-Gramaje Ph.D. , Raquel Alfonso Ballester M.D., Ph.D. , Norberto Casinello M.D., Ph.D. , María Capilla Lozano M.D. , María Desamparados Escudero-García M.D., Ph.D. , Cristina Montón M.D., Ph.D. , Amparo Urios Lluch Ph.D. , Juan Antonio Carbonell-Asins Ph.D. , Paloma Lluch M.D., Ph.D. , Carmina Montoliu Félix Ph.D. , María Pilar Ballester M.D., Ph.D.

Background

Neurological impairment has been recognized in up to 70% of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity, which can lead to poor quality of life (QoL).

Objectives

To evaluate the impact of bariatric surgery on neurological alterations, QoL, and factors associated with neurological response.

Setting

Tertiary University Hospital, Spain

Methods

A prospective, longitudinal study was conducted in 53 patients undergoing bariatric surgery between 2021 and 2023. Psychometric tests and the SF-12 questionnaire were performed 1-month before and 3- and 6-months after surgery. Liver biopsy was performed during the intervention. A group of healthy controls was included at a 2:1 ratio, as a reference.

Results

Mean age was 49 (SD 9) years, 68% were female and median body mass index was 45 (interquartile range [IQR] 39-49) kg/m2. No patients presented advanced fibrosis (F3-F4) and only 14% showed a nonalcoholic fatty liver disease (NAFLD) score >3 in liver biopsy. A total of 63% exhibited alterations in verbal fluency (Animal Naming Test -ANT-), with a significant improvement at 3- (36%; P = .035) and 6-months (35%; P < .001). Psychomotor speed and selective attention (75% versus 48%; P = .004) as well as bimanual and visuomotor coordination (90% vs. 74%; P = .021) showed a significant improvement after surgery. QoL increased globally, mainly in the physical sphere (P < .001). Older age, diabetes and IL-6 levels were associated with an altered ANT after surgery.

Conclusions

Neurological impairment is common in patients with MASLD and severe obesity. Cognitive, motor performance, and QoL improve after bariatric surgery. Age, diabetes, and inflammatory markers are predictors of poor response.
背景:高达70%的代谢功能障碍相关脂肪变性肝病(MASLD)和肥胖患者存在神经功能障碍,这可能导致生活质量差(QoL)。目的:评估减肥手术对神经改变、生活质量和神经反应相关因素的影响。方法:对2021年至2023年间接受减肥手术的53例患者进行前瞻性、纵向研究。术前1个月、术后3个月和6个月分别进行心理测试和SF-12问卷。干预期间进行肝活检。以2:1的比例纳入一组健康对照作为参考。结果:平均年龄49岁(SD 9),女性占68%,中位体重指数为45(四分位数间距[IQR] 39 ~ 49) kg/m2。没有患者出现晚期纤维化(F3-F4),只有14%的患者在肝活检中显示非酒精性脂肪性肝病(NAFLD)评分为bb0.3。总共有63%的人表现出语言流畅性的改变(动物命名测试- ant -),在3个月(36%,P = 0.035)和6个月(35%,P < 0.001)时有显著改善。精神运动速度和选择性注意(75%对48%,P = 0.004)以及双手和视觉运动协调(90%对74%,P = 0.021)在手术后有显著改善。整体生活质量增加,主要在物理领域(P < 0.001)。老年、糖尿病和IL-6水平与手术后ANT的改变有关。结论:神经功能损害在重度肥胖患者中很常见。减肥手术后认知、运动表现和生活质量得到改善。年龄、糖尿病和炎症标志物是不良反应的预测因子。
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引用次数: 0
Response to comment on “Magnetic duodenoileal anastomosis with sleeve gastrectomy: a prospective multicenter study” by L. Biertho, S. Marceau, M. Nadeau, S. Lebel, F. Julien, A. Tchernof, T. Ransom, R. T. Spence, and J. Ellsmere 对L. Biertho、S. Marceau、M. Nadeau、S. Lebel、F. Julien、a . Tchernof、T. Ransom、R. T. Spence和J. Ellsmere发表的“磁性十二指肠油膜吻合与袖胃切除术:一项前瞻性多中心研究”评论的回应。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.010
Laurent Biertho M.D., Simon Marceau M.D., Mélanie Nadeau M.Sc., Stéfane Lebel M.D., François Julien M.D., André Tchernof Ph.D., Thomas Ransom M.D., Richard T. Spence M.D., James Ellsmere M.D.
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引用次数: 0
Comment on “Evaluation of patients on immunosuppressants undergoing sleeve gastrectomy, Roux-en-Y gastric bypass, and duodenal switch: analysis of 19,414 patients” 对“19414例套筒胃切除术、Roux-en-Y胃分流术及十二指肠转肠术患者免疫抑制剂的评价”的评论。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.08.005
Prajnasini Satapathy M.D., Rachana Mehta M.Sc., Ranjana Sah M.D.
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引用次数: 0
Association between cardiac axis changes and excess weight loss following bariatric surgery 心轴变化与减肥手术后体重减轻之间的关系。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.08.025
Lucas Friedrich Fontoura M.D., Ph.D. , Lucas S. Matzenbacher M.D. , Laura Gomes Boabaid de Barros , Ana Gabriela Rodrigues Haussen , Mariana Kude Perrone , Vicenzo Gheno , Helena Toniazzi Uchôa , Andres Di Leoni Ferrari M.D., Ph.D. , Claudio Cora Mottin M.D., Ph.D. , Alexandre Vontobel Padoin M.D., Ph.D. , Janine Alessi M.D., Ph.D. , Gabriela Heiden Telo M.D., Ph.D.

Background

Excess weight has been linked to leftward QRS axis deviation, but the impact of significant weight loss on cardiac axis remains unclear.

Objectives

To evaluate the association between excess weight loss following bariatric surgery and changes in the electrocardiographic cardiac axis.

Setting

Single academic medical center in Brazil.

Methods

Retrospective cohort including patients who underwent bariatric surgery at a multidisciplinary obesity treatment center in Southern Brazil. Pre- and postoperative electrocardiographies (ECGs) were analyzed, with exact cardiac axis determined using the Novosel equation. The main outcome was the association between the percentage of excess weight loss (EWL%) and the change in cardiac axis (Δθa), defined as the difference between the pre- and postoperative cardiac axis values. Multivariable linear regression models were applied, adjusting for time since bariatric surgery.

Results

A total of 60 participants (mean age of 42.15 years, 68.3% female) were included. The mean preoperative body mass index was 42.9 ± 6.2 kg/m2, decreasing to 28.9 ± 5.2 kg/m2 postoperatively, with an average EWL% of 66.7 ± 16%. The mean cardiac axis shifted from 27.99 ± 30.77 degrees preoperatively to 42.37 ± 34.06 degrees postoperatively (Δθa = 14.38 ± 26.61 degrees). A 1% increase in EWL% was associated with a .44-degree increase in the cardiac axis (B = .44; 95% confidence interval [CI]: .15–.80; P = .009).

Conclusions

Weight loss following bariatric surgery is associated with changes in the electrocardiographic cardiac axis, with a trend toward rightward shifts. The clinical significance of these findings remains uncertain, and further studies are needed to confirm and clarify the prognostic value of these electrocardiographic adaptations.
背景:超重与QRS轴向左偏移有关,但体重显著减轻对心轴的影响尚不清楚。目的:评价减肥手术后体重减轻与心轴心电图变化之间的关系。环境:巴西唯一的学术医疗中心。方法:回顾性队列研究,包括在巴西南部多学科肥胖治疗中心接受减肥手术的患者。分析术前和术后心电图(ECGs),使用Novosel方程确定确切的心轴。主要结局是超重减重百分比(EWL%)与心轴变化(Δθa)之间的关系,定义为术前和术后心轴值之间的差异。应用多变量线性回归模型,调整减肥手术后的时间。结果:共纳入60例受试者,平均年龄42.15岁,女性68.3%。术前平均体重指数为42.9±6.2 kg/m2,术后降至28.9±5.2 kg/m2,平均EWL%为66.7±16%。平均心轴由术前27.99±30.77度偏移至术后42.37±34.06度(Δθa = 14.38±26.61度)。每增加1%的EWL%与。心轴升高44度(B = 0.44; 95%可信区间[CI]: 0.15 - 0.80; P = 0.009)。结论:减肥手术后体重减轻与心电图心轴的改变有关,并有向右移动的趋势。这些发现的临床意义仍不确定,需要进一步的研究来证实和澄清这些心电图适应的预后价值。
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引用次数: 0
Kidney transplantation after bariatric surgery—Outcomes from a 30-year experience 减肥手术后肾移植:30年经验的结果。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.09.005
Abraham J. Matar M.D. , M. Caner Aydin M.D. , Daniel Waller M.S. , Erika Helgeson Ph.D. , David Vock Ph.D. , Matthew Wright M.D. , Karthik Ramanathan M.D. , Vanessa Humphreville M.D. , Erik B. Finger M.D., Ph.D. , Timothy Pruett M.D. , Arthur J. Matas M.D. , Eric Wise M.D. , Sayeed Ikramuddin M.D. , Raja Kandaswamy M.D. , Daniel B. Leslie M.D.

Background

The clinical impact of metabolic and bariatric surgery (MBS) before kidney transplantation (KTx) is evolving.

Methods

This was a single-center retrospective study of all adult patients between January 1, 1994, and December 31, 2024, undergoing KTx with a history of antecedent MBS. Primary outcomes included death-censored graft survival and overall patient survival.

Results

Among 4538 KTx recipients, 116 (2.6%) had a history of previous MBS. Median time (interquartile range, range) between BS and KTx was 6.8 years (10.9, .3–45.5). Of these, patients underwent Roux-en-Y gastric bypass (RYGB, n = 77, 66.4%), vertical sleeve gastrectomy (VSG, n = 23, 19.8%), gastric banding (n = 6, 5.2%), vertical banded gastroplasty (n = 5, 4.3%), jejunoileal bypass (n = 3, 2.6%), and duodenal switch (n = 2, 1.7%). The type of MBS (VSG versus RYGB) did not impact long-term outcomes. In total, 28 (24.1%) patients underwent planned BS with the specific intention of reaching an acceptable body mass index (BMI) threshold for KTx. Median time between BS and KTx for these patients was 1.1 years (1.3, .3–4.7). Nine patients underwent RYGB, and 19 underwent VSG. Median BMI (IQR) was reduced from 43.8 kg/m2 (6.9) at time of MBS to 32.1 kg/m2 (7.3) at time of KTx. One-year overall survival and death-censored graft survival were 96.4% and 100%, respectively. At median follow-up of 2.7 years, overall survival and death-censored graft survival were 85.7% and 89.3%. A propensity matched analysis revealed no differences in the rates of surgical complications after KTx among those with BS compared to matched controls without MBS.

Conclusions

This study represents the largest single-center series of patients with MBS before KTx. Timing of antecedent BS and type of BS did not impact long-term graft or patient outcomes. Planned MBS with either VSG or RYGB followed by KTx in patients with an initially prohibitive BMI is associated with excellent short- and medium-term outcomes.
背景:肾移植(KTx)前代谢和减肥手术(MBS)的临床影响正在不断发展。方法:这是一项单中心回顾性研究,研究对象为1994年1月1日至2024年12月31日期间接受KTx治疗且既往有MBS病史的所有成年患者。主要结局包括死亡剔除的移植物生存和患者总生存。结果:在4538名KTx接受者中,116名(2.6%)有既往MBS病史。BS和KTx的中位时间(四分位数间距,范围)为6.8年(10.9,0.3 -45.5)。其中,患者接受Roux-en-Y胃旁路术(RYGB, n = 77, 66.4%)、垂直袖胃切除术(VSG, n = 23, 19.8%)、胃束带术(n = 6, 5.2%)、垂直束带胃成形术(n = 5, 4.3%)、空肠回肠旁路术(n = 3, 2.6%)和十二指肠切换术(n = 2, 1.7%)。MBS类型(VSG vs RYGB)对长期预后没有影响。总共有28例(24.1%)患者接受了有计划的BS,其具体目的是达到可接受的KTx体重指数(BMI)阈值。这些患者BS和KTx之间的中位时间为1.1年(1.3年,0.3 -4.7年)。RYGB 9例,VSG 19例。中位BMI (IQR)从MBS时的43.8 kg/m2(6.9)降至KTx时的32.1 kg/m2(7.3)。一年总生存率为96.4%,移植瘤死亡后生存率为100%。中位随访2.7年,总生存率和死亡后移植生存率分别为85.7%和89.3%。倾向匹配分析显示,与没有MBS的对照组相比,BS患者在KTx后的手术并发症发生率没有差异。结论:该研究代表了KTx前MBS患者最大的单中心系列研究。先前BS的时间和BS的类型对移植或患者的长期预后没有影响。在最初BMI过高的患者中,VSG或RYGB合并KTx的计划MBS与良好的中短期预后相关。
{"title":"Kidney transplantation after bariatric surgery—Outcomes from a 30-year experience","authors":"Abraham J. Matar M.D. ,&nbsp;M. Caner Aydin M.D. ,&nbsp;Daniel Waller M.S. ,&nbsp;Erika Helgeson Ph.D. ,&nbsp;David Vock Ph.D. ,&nbsp;Matthew Wright M.D. ,&nbsp;Karthik Ramanathan M.D. ,&nbsp;Vanessa Humphreville M.D. ,&nbsp;Erik B. Finger M.D., Ph.D. ,&nbsp;Timothy Pruett M.D. ,&nbsp;Arthur J. Matas M.D. ,&nbsp;Eric Wise M.D. ,&nbsp;Sayeed Ikramuddin M.D. ,&nbsp;Raja Kandaswamy M.D. ,&nbsp;Daniel B. Leslie M.D.","doi":"10.1016/j.soard.2025.09.005","DOIUrl":"10.1016/j.soard.2025.09.005","url":null,"abstract":"<div><h3>Background</h3><div>The clinical impact of metabolic and bariatric surgery (MBS) before kidney transplantation (KTx) is evolving.</div></div><div><h3>Methods</h3><div>This was a single-center retrospective study of all adult patients between January 1, 1994, and December 31, 2024, undergoing KTx with a history of antecedent MBS. Primary outcomes included death-censored graft survival and overall patient survival.</div></div><div><h3>Results</h3><div>Among 4538 KTx recipients, 116 (2.6%) had a history of previous MBS. Median time (interquartile range, range) between BS and KTx was 6.8 years (10.9, .3–45.5). Of these, patients underwent Roux-en-Y gastric bypass (RYGB, n = 77, 66.4%), vertical sleeve gastrectomy (VSG, n = 23, 19.8%), gastric banding (n = 6, 5.2%), vertical banded gastroplasty (n = 5, 4.3%), jejunoileal bypass (n = 3, 2.6%), and duodenal switch (n = 2, 1.7%). The type of MBS (VSG versus RYGB) did not impact long-term outcomes. In total, 28 (24.1%) patients underwent planned BS with the specific intention of reaching an acceptable body mass index (BMI) threshold for KTx. Median time between BS and KTx for these patients was 1.1 years (1.3, .3–4.7). Nine patients underwent RYGB, and 19 underwent VSG. Median BMI (IQR) was reduced from 43.8 kg/m<sup>2</sup> (6.9) at time of MBS to 32.1 kg/m<sup>2</sup> (7.3) at time of KTx. One-year overall survival and death-censored graft survival were 96.4% and 100%, respectively. At median follow-up of 2.7 years, overall survival and death-censored graft survival were 85.7% and 89.3%. A propensity matched analysis revealed no differences in the rates of surgical complications after KTx among those with BS compared to matched controls without MBS.</div></div><div><h3>Conclusions</h3><div>This study represents the largest single-center series of patients with MBS before KTx. Timing of antecedent BS and type of BS did not impact long-term graft or patient outcomes. Planned MBS with either VSG or RYGB followed by KTx in patients with an initially prohibitive BMI is associated with excellent short- and medium-term outcomes.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 57-65"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometric properties of the Eating loss of control scale in a sample of Hispanic persons seeking metabolic and bariatric surgery 在寻求代谢和减肥手术的西班牙裔患者样本中饮食失去控制量表的心理测量特性。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.09.009
Ryan J. Marek Ph.D , Valentina Ivezaj Ph.D , Manish S. Parikh M.S , Maansi Jayade B.S , Jessica Lawson Ph.D , Carlos M. Grilo Ph.D

Background

Eating disorders are routinely assessed for in persons seeking metabolic and bariatric surgery (MBS). One construct in particular, loss-of-control over eating, appears to be important to understanding clinical needs and outcomes in MBS. The Eating Loss of Control Scale (ELOCS) has received some initial validation for use in MBS settings, but its factor structure remains uncertain and its performance about diverse groups is unknown.

Objectives

The purpose of this study is to explore further the psychometric properties and factor structure of ELOCS in Hispanic persons seeking MBS and to establish measurement invariance between the English- and Spanish-language version.

Setting

Academic Medical Center

Methods

Participants (n = 618) undergoing evaluations prior to bariatric surgery who identified as Hispanic and consented to participate in this research study completed self-report measures of eating disorders and loss of control over eating. Of the 618 participants, a total of 318 persons preferred English and were administered English versions of the measures and 300 persons preferred Spanish and were administered Spanish versions of the measures.

Results

Factor analyses supported a one-factor, 18-item ELOCS (after removal of 2 original items 6 and 20), though Comparative Fit Index (CFI) was slightly below conventional cut-offs and RMESA were mediocre. The measure was also invariant across language translations. The 18-item ELOCS had good internal consistency (α = .97), though the internal consistency suggests that there is still considerable redundancy on the measure. The ELOCS-18 also demonstrated good convergent and discriminant validity with an established eating disorder measure.

Conclusions

The 18-item ELOCS is a reliable and valid measure to use in MBS settings, though factor analyses suggest further psychometric work is warranted. A Spanish-translated version assesses the construct of LOC similarly to its English counterpart. Due to some below threshold indices, the ELOCS factor structure should be further studied.
背景:在寻求代谢和减肥手术(MBS)的患者中,饮食失调是常规评估。其中一个概念,对饮食失去控制,似乎对理解MBS的临床需求和结果很重要。进食失去控制量表(ELOCS)在MBS环境下的应用已经获得了一些初步的验证,但其因子结构仍不确定,其在不同群体中的表现尚不清楚。目的:本研究的目的是进一步探讨寻求MBS的西班牙裔人的ELOCS的心理测量特征和因素结构,并建立英语和西班牙语版本之间的测量不变性。方法:接受减肥手术前评估的西班牙裔参与者(n = 618)同意参加本研究,完成饮食失调和饮食失控的自我报告测量。在618名参与者中,共有318名喜欢英语的人接受了英语版本的测试,300名喜欢西班牙语的人接受了西班牙语版本的测试。结果:因子分析支持单因素18项ELOCS(去除2个原始项目6和20后),但比较拟合指数(CFI)略低于常规截断值,RMESA一般。这一衡量标准在不同语言的翻译中也是不变的。18项ELOCS具有良好的内部一致性(α = 0.97),但内部一致性表明在测量上仍存在相当大的冗余。ELOCS-18也显示出良好的收敛效度和判别效度与既定的饮食失调测量。结论:18项ELOCS是一种可靠有效的测量方法,可用于MBS设置,尽管因素分析表明进一步的心理测量工作是必要的。西班牙语翻译版本评估LOC结构的方法与英文版本类似。由于一些指标低于阈值,需要进一步研究ELOCS的因子结构。
{"title":"Psychometric properties of the Eating loss of control scale in a sample of Hispanic persons seeking metabolic and bariatric surgery","authors":"Ryan J. Marek Ph.D ,&nbsp;Valentina Ivezaj Ph.D ,&nbsp;Manish S. Parikh M.S ,&nbsp;Maansi Jayade B.S ,&nbsp;Jessica Lawson Ph.D ,&nbsp;Carlos M. Grilo Ph.D","doi":"10.1016/j.soard.2025.09.009","DOIUrl":"10.1016/j.soard.2025.09.009","url":null,"abstract":"<div><h3>Background</h3><div>Eating disorders are routinely assessed for in persons seeking metabolic and bariatric surgery (MBS). One construct in particular, loss-of-control over eating, appears to be important to understanding clinical needs and outcomes in MBS. The Eating Loss of Control Scale (ELOCS) has received some initial validation for use in MBS settings, but its factor structure remains uncertain and its performance about diverse groups is unknown.</div></div><div><h3>Objectives</h3><div>The purpose of this study is to explore further the psychometric properties and factor structure of ELOCS in Hispanic persons seeking MBS and to establish measurement invariance between the English- and Spanish-language version.</div></div><div><h3>Setting</h3><div>Academic Medical Center</div></div><div><h3>Methods</h3><div>Participants (n = 618) undergoing evaluations prior to bariatric surgery who identified as Hispanic and consented to participate in this research study completed self-report measures of eating disorders and loss of control over eating. Of the 618 participants, a total of 318 persons preferred English and were administered English versions of the measures and 300 persons preferred Spanish and were administered Spanish versions of the measures.</div></div><div><h3>Results</h3><div>Factor analyses supported a one-factor, 18-item ELOCS (after removal of 2 original items 6 and 20), though Comparative Fit Index (CFI) was slightly below conventional cut-offs and RMESA were mediocre. The measure was also invariant across language translations. The 18-item ELOCS had good internal consistency (α = .97), though the internal consistency suggests that there is still considerable redundancy on the measure. The ELOCS-18 also demonstrated good convergent and discriminant validity with an established eating disorder measure.</div></div><div><h3>Conclusions</h3><div>The 18-item ELOCS is a reliable and valid measure to use in MBS settings, though factor analyses suggest further psychometric work is warranted. A Spanish-translated version assesses the construct of LOC similarly to its English counterpart. Due to some below threshold indices, the ELOCS factor structure should be further studied.</div></div>","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 99-105"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of neoadjuvant glucagon-like-peptide 1 receptor agonists on weight loss after bariatric surgery 新辅助胰高血糖素样肽1受体激动剂对减肥手术后体重减轻的影响。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.09.010
Maria Charina Benavidez M.D., Sophia Redpath B.A., Stephanie Trautmann M.D., Santiago Ceron M.D, Scott Schimpke M.D., Jonathan Myers M.D., Philip Omotosho M.D., Alfonso Torquati M.D., Nicholas J. Skertich M.D.

Background

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prevalent medications used to treat patients with obesity. While bariatric surgery remains the most successful single intervention, many surgical patients have been on a GLP-1RA.

Objectives

This study aims to determine if the neoadjuvant use of GLP-1RA affects surgical weight loss.

Setting

University Hospital, United States.

Methods

This retrospective cohort study compared outcomes of patients undergoing sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) who were treated preoperatively with and without GLP-1RAs from July 2022 to June 2023. T-tests and multivariable analyses were utilized to determine significant differences in weight loss.

Results

Of 422 patients, 36 (8.5%) received neoadjuvant GLP-1RAs and 386 (91.5%) did not. Mean preoperative body mass index (BMI) was 47 for both groups. Median time for GLP1-RAs was 12 months prior to bariatric surgery but not resumed after. There was a significant difference between patients who received neoadjuvant GLP1-RAs versus those who did not at 2 weeks (mean change in BMI of −4.9 vs −3.8, P = .006), but not at 3- (−9 vs −8.4, P = .25), 6- (−12.4 vs −11.2, P = .13), or 12 months (−14.2 [n = 21] vs −12.9 [n = 249], P = .25) postoperatively. Multivariable analysis showed no difference in weight loss at any time point when adjusting for operation type.

Conclusions

Although neoadjuvant GLP-1RAs did not significantly impact weight loss after bariatric surgery, there was an additive weight loss effect.
背景:胰高血糖素样肽-1受体激动剂(GLP-1RAs)越来越普遍用于治疗肥胖患者。虽然减肥手术仍然是最成功的单一干预措施,但许多手术患者已经使用了GLP-1RA。目的:本研究旨在确定GLP-1RA的新辅助使用是否影响手术减肥。地点:美国大学医院。方法:本回顾性队列研究比较了2022年7月至2023年6月术前接受GLP-1RAs治疗和不接受GLP-1RAs治疗的袖式胃切除术(SG)或Roux-en-Y胃旁路术(RYGB)患者的结果。使用t检验和多变量分析来确定体重减轻的显著差异。结果:422例患者中,36例(8.5%)接受新辅助GLP-1RAs治疗,386例(91.5%)未接受新辅助GLP-1RAs治疗。两组术前平均体重指数(BMI)均为47。减肥手术前GLP1-RAs的中位时间为12个月,但手术后没有恢复。接受新辅助GLP1-RAs治疗的患者与未接受新辅助GLP1-RAs治疗的患者在术后2周(BMI平均变化为-4.9 vs -3.8, P = 0.006),但在术后3个月(-9 vs -8.4, P = 0.25)、6个月(-12.4 vs -11.2, P = 0.13)或12个月(-14.2 [n = 21] vs -12.9 [n = 249], P = 0.25)时差异无统计学意义。多变量分析显示,在调整手术类型后,任何时间点的体重减轻均无差异。结论:虽然新辅助GLP-1RAs对减肥手术后的体重减轻没有显著影响,但存在附加的体重减轻作用。
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引用次数: 0
Comment on: “Assessment of changes in left ventricular myocardial work using the pressure strain loop after metabolic and bariatric surgery: a prospective nonrandomized cohort study” 评论:“代谢和减肥手术后使用压力应变环评估左心室心肌功的变化:一项前瞻性非随机队列研究”。
IF 3.8 3区 医学 Q1 SURGERY Pub Date : 2026-01-01 DOI: 10.1016/j.soard.2025.11.002
Rodolfo J. Oviedo M.D., F.A.C.S., F.R.C.S., F.I.C.S., F.A.S.M.B.S., D.A.B.S.-F.P.D.M.B.S.
{"title":"Comment on: “Assessment of changes in left ventricular myocardial work using the pressure strain loop after metabolic and bariatric surgery: a prospective nonrandomized cohort study”","authors":"Rodolfo J. Oviedo M.D., F.A.C.S., F.R.C.S., F.I.C.S., F.A.S.M.B.S., D.A.B.S.-F.P.D.M.B.S.","doi":"10.1016/j.soard.2025.11.002","DOIUrl":"10.1016/j.soard.2025.11.002","url":null,"abstract":"","PeriodicalId":49462,"journal":{"name":"Surgery for Obesity and Related Diseases","volume":"22 1","pages":"Pages 37-38"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Surgery for Obesity and Related Diseases
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