Nutrition Metabolism and Cardiovascular Diseases最新文献

Background and aims: Inflammation, lipid signaling, and their interplay are involved in the pathogenesis and development of cardiovascular diseases (CVDs), while the relationships of composite indices combining inflammation and lipids with CVD remained inexplicit.

Methods and results: Our study enrolled 8581 adults from the National Health and Nutrition Examination Survey 2015-2018. Logistic regression model was applied to assess the associations of high-sensitivity C-reactive protein (hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio with CVD prevalence. Potential mediating effects of hypertension, diabetes, hypercholesterolemia, and obesity on significant associations were explored. Receiver operating characteristic (ROC) curves were generated to compare diagnostic values of the hs-CRP/HDL-C ratio, HDL-C, and hs-CRP. Compared with those in the first quartile of the hs-CRP/HDL-C ratio, participants in the fourth quartile presented higher risks of CVD subtypes and total CVD. Each one-unit increment of the log-transformed hs-CRP/HDL-C ratio was associated with a 25 % increase in CVD risk (95 % confidence interval: 1.11, 1.41) with significant uptrends across the hs-CRP/HDL-C ratio quartiles. Four metabolic disorders significantly mediated associations of the hs-CRP/HDL-C ratio with CVDs. Younger participants were more sensitive to higher hs-CRP/HDL-C ratio with significant interactions in CVD. ROC curves further illustrated the relatively good diagnostic efficacy of the hs-CRP/HDL-C ratio for CVD.

Conclusion: The hs-CRP/HDL-C ratio was a significant risk factor for CVD among US adults, in which hypertension, diabetes, hypercholesterolemia, and obesity played important mediating roles. Early attention to people with elevated hs-CRP/HDL-C ratio would be helpful for CVD risk reduction.

Background and aims: Early life factors have been suggested to be associated with later cardiometabolic risk in children, adolescents and adults. Our study aimed to investigate the associations between early life factors and metabolic syndrome (MetS) in children and adolescents.

Methods and results: Our analysis sample comprised of 8852 children aged 2-9 years at baseline that participated in up to three examination waves of the pan-European IDEFICS/I.Family cohort (baseline: 2007/08, 1st follow-up 2009/10, 2nd follow-up 2013/14). Mixed-effects models were used to estimate the associations between early life factors and MetS score and z-scores of waist circumference (WC), systolic (SBP) and diastolic blood pressure (DBP), Homeostasis Model Assessment for Insulin Resistance, high density lipoprotein cholesterol (HDL) and triglycerides. Being born large for gestational age (LGA) showed a positive association with MetS score (β = 0.67; 99%CI 0.44, 0.90) and with WC z-score (β = 0.51; 99%CI 0.39, 0.63) and was weakly inversely associated with HDL z-score. Being born small for gestational age (SGA) was associated with lower WC z-score (ß = -0.26; 99%CI -0.37, -0.16), with a lower MetS score (ß = -0.13; 99%CI -0.33, 0.08) and slightly higher z-scores of SBP and DBP. Weight gain during pregnancy was positively associated with MetS score and WC z-score while premature birth was positively associated with SBP.

Conclusions: Children born LGA, SGA or preterm may warrant closer monitoring to prevent MetS later on.

Background and aims: To assess the relationship between body composition indicators and inflammatory biomarkers in children and adolescents of the GENOBOX study.

Methods and results: Anthropometry data from 264 subjects from the subsample of Zaragoza (Spain) included: weight, height, waist circumference, body mass index and triponderal index. Body composition was determined by Dual-energy X-ray Absorptiometry (DXA), obtaining visceral adipose tissue, fat mass index and lean mass index. Age and sex specific z-scores were computed. Simple linear regression models were performed with inflammatory biomarkers (hsCRP, IL8, TNF-α, adiponectin, leptin and resistin) as dependent variables, and each of the body composition indices as independent variables. Prepubertal boys had higher IL8 and resistin values and pubertal girls had higher HOMA-IR and leptin values. hsCPR and leptin were associated with fat mass, both in prepubertals and pubertals, independently of lean mass, and regardless of how body composition was measured. All body composition indices were inversely associated with adiponectin, except for fat mass index in pubertals, but none of them were statistically significant.

Conclusion: A positive association between hsCRP and leptin with all body fat composition parameters, measured by standard nutritional indicators and DXA, was observed in both sexual stages.

Background and aims: The adipocyte-derived adiponectin (APN) has potent insulin-sensitizing and anti-inflammatory properties. The adipose tissue is known to be the main source for APN in the circulation, but sites and mechanisms which remove APN from blood are still unknown in humans.

Methods and results: We reviewed APN data obtained in previous studies in which the inter-organ exchange of amino acids and cytokines was measured in our laboratory. Results for kidney and splanchnic arterio-venous differences of APN were available for 5 subjects (age 57 ± 7 years, mean eGFR 79 ± 4 ml/min 1.73 m²). Both the liver and renal vein concentrations of total APN were lower than in the artery (by ∼32 and 20 %, respectively p < 0.05) indicating removal from blood; a similar trend (liver and renal vein level lower than the arterial by ∼22 and 15 %, respectively, p = NS) was observed for high molecular weight (HMW) APN.

Conclusions: The present study identifies the splanchnic organs and the kidney as major sites for APN removal from blood in humans. Our data provide new understanding of kidney APN metabolism and suggests that reduced handling by the human kidney is a major factor to increase circulating APN in renal disease.

Background and aims: This study compares three methods to determine central adiposity (waist circumference -WC - and visceral adipose tissue - VAT - estimated by dual-energy x-ray absorptiometry - DXA, and by magnetic resonance imaging - MRI) in their ability to predict increases in cardiometabolic risk (CMR) markers in young individuals. We examined their associations with CMR in 47 men and women aged 25-40.

Methods and results: VAT mass was assessed using DXA and MRI. Blood samples were analyzed for CMR markers. Associations between central adiposity measurements and CMR factors were analyzed using Spearman's correlation coefficient, and the ability of these three central adiposity measurements to detect increased CMR was compared using receiver operating characteristic (ROC) curves. Similar to what was observed for the MRI-DXA and VAT-DXA, WC showed strong correlations with LDL-c and triglycerides (TG) and an inverse correlation with HDL-c (rho = -0.657 MRI, rho = -0.628 DXA, and rho = -0.604 WC, p < 0.01). On the other hand, only MRI-VAT and WC were associated with insulin and HOMA-IR (rho = 0.341 MRI and rho = 0.421 WC, p < 0.01). Central adiposity measurements were negatively associated with cold-induced ¹⁸F-FDG uptake in subcutaneous adipose tissue and positively associated with VAT TG content. No significant differences were observed when comparing the three central adiposity measurements in ROC curve analysis, and all measurements could predict increases in CMR markers and the combined CMR index.

Conclusions: This study reinforces the importance of using WC to assess increases in CMR markers among young adults. Given its practicality and efficacy, WC should be recommended in health centers to assess CMR risk.

Background and aim: Prior research has established a relationship between homocysteine (Hcy) and serum uric acid (SUA) levels; however, the precise mechanisms underlying this association remain unclear. The objective of this research was to explore the correlation between SUA and Hcy and to evaluate the possible role of kidney function as a mediator in the connection between SUA and Hcy.

Methods and results: Consecutive enrollment of 16870 participants aged 20-60 years was conducted at the Third Xiangya Hospital of Central South University. Self-reported health questionnaires were used to gather information on health behaviors and medical backgrounds. Trained personnel performed laboratory examinations using standard methods. A mediation analysis was performed to explore the possible effect of renal function on the association between SUA and Hcy levels. Estimated glomerular filtration rate (eGFR) was used to assess kidney function. Logistic regression analysis showed that SUA levels were positively correlated with Hcy levels and hyperhomocysteinemia (HHcy) risk (p < 0.01). Subgroup analysis showed the robustness of the results. Significant mediation effects of eGFR were found in the relationship between SUA and Hcy, as demonstrated by the subsequent mediation analysis. In the overall study group, the percentage of eGFR mediated in the association between SUA and Hcy was 63.36 %, with 41.59 % and 57.59 % in women and men, respectively.

Conclusions: SUA was positively correlated with Hcy and HHcy risks, and the effects of SUA on Hcy may be mediated by renal function indicators (eGFR).

Background and aim: Intermittent fasting (IF) has been demonstrated to enhance human health through several mechanisms. However, it is still unclear whether those health benefits are independent of caloric restriction (CR)-induced weight loss. This systematic review and meta-analysis aimed to compare isocaloric IF and CR regarding anthropometric measurements, adherence, metabolic profile, inflammatory biomarkers, and adipokines in adults and elderlies.

Methods and results: Comprehensive research was conducted usin four major databases including Embase, PubMed, Scopus, and Google Scholar without date restriction. Mean differences of the change from baseline ± change SD were calculated as the differences between IF and CR groups. Subgroup analysis was performed according to intervention duration (short-, medium-, and long-term). To determine the reliability of our findings, GRADE assessment was performed. As a result, 20 RCTs were included in this systematic review and meta-analysis. IF groups had significant reductions in fat mass (kg) (P = 0.006) and Interleukin-6 (P < 0.00001) in the short term and fat mass (%) (P = 0.0002), waist circumference (P = 0.005), fasting blood insulin (P < 0.00001) and HOMA-IR (P = 0.04) in the long term. CR groups had significantly lower hunger (P = 0.003), fatigue (P = 0.04), and TG (P = 0.03).

Conclusions: IF may be an effective alternative to CR but is not superior to CR in enhancing human health. Due to the low number of long-term studies, future studies should focus on conducting longitudinal randomized trials comparing IF and CR in different populations, age groups, and IF patterns.

Background and aims: Worldwide, the prevalence of overweight and obesity has increased. We examined sex-specific patterns in the relationship of body mass index (BMI) with muscle strength and physical function among older Mexican Americans over time.

Methods and results: Participants (N = 1975) aged ≥65 years (mean = 72.4) were from a longitudinal study of Mexican American older adults (1993/94-2016). Measures collected at each interview included socio-demographics and health status; BMI (independent variable); short physical performance battery (SPPB) and handgrip strength (HGS) (outcomes). Participants were grouped into underweight (<18.5 kg/m²); normal weight (18.5-24.9 kg/m²); overweight (25-29.9 kg/m²); class I obesity (30-34.9 kg/m²); and class II/morbid obesity (≥35 kg/m²). Changes in SPPB and HGS by BMI and sex over time were estimated using general linear mixed models. Males deemed overweight (β = 0.46; Standard Error [SE] = 0.11; p-value = 0.0001), class I obesity (β = 0.43; SE = 0.15; p-value = 0.0037), and class II/morbid obesity (β = 0.66; SE = 0.29; p-value = 0.0246) scored higher in SPPB than those with normal weight. Females deemed overweight (β = 0.49; SE = 0.10; p-value = 0.0001) and class I obesity (β = 0.32; SE = 0.11; p-value = 0.0047) scored higher on the SPPB than those with normal weight. Males and females deemed overweight (β = 0.56; SE = 0.29; p-value = 0.0535 and β = 0.65; SE = 0.18; p-value = 0.0003, respectively) and class I obesity (β = 1.08; SE = 0.39; p-value = 0.0062 and β = 0.92; SE = 0.22; p-value = 0.0001, respectively) scored higher in HGS than those with normal weight.

Conclusion: We found no sex differences in the trajectories of decline for HGS and physical function. Females and males classed as overweight or class I obesity experienced slower decline in HGS and physical function.

Background and aims: This study evaluated the predictive value of the APF risk score in East Asian patients undergoing open nephrectomy and its correlation with hypertension and NAFLD.

Methods and results: A retrospective study used the clinical data of 82 patients who underwent ON between January 2010 and December 2022. Per their APF score, patients were categorized into groups A (0-2 points) and B (3-4 points). Logistic regression analyses were used to compare the overall clinical data between the two groups and identify potential risk factors. Intraoperative APF prevalence was significantly higher in group B compared to group A (P < 0.001). Group B patients were older (63.06 ± 8.88 vs. 53.69 ± 15.21 years) and had higher incidences of hypertension (P < 0.001), diabetes (P = 0.002), and NAFLD (P < 0.001). Preoperative CT scans showed significant differences in posterior (P = 0.009) and lateral perinephric fat thickness (P < 0.001), and perinephric stranding (P < 0.001). Group B also had a higher proportion of malignant tumors (P = 0.039). Multivariate logistic regression revealed that NAFLD (OR = 9.053, P = 0.010) and hypertension (OR = 5.181, P = 0.025) were highly correlated with APF risk scores.

Conclusions: In this study, we found that the newly developed APF risk score had significant value in predicting APF in East Asian patients undergoing open nephrectomy. Additionally, NAFLD and hypertension were highly correlated with elevated APF risk scores.

Background and aims: The purpose of this study was to examine the associations of basic activities of daily living (BADL) and its longitudinal changes with cardiovascular disease (CVD) risk among older population.

Methods and results: We conducted a prospective analysis of the Chinese Longitudinal Healthy Longevity Survey between 2008 and 2018 in 7051 participants aged 65 years or over. Cox proportional hazards models were performed to evaluate the associations of baseline and longitudinal changes in BADL with the incidence of CVD. A total of 1510 incident CVD cases were identified. The participants with BADL limitation at baseline had a 67 % increased risk of CVD compared with those without BADL limitation (multivariable-adjusted hazards ratio (HR): 1.67, 95 % confidence interval (CI): 1.35-2.07). Moreover, participants with persistent BADL limitation (HR: 2.25, 95 % CI: 1.73-2.93), BADL from limitation to non-limitation (HR: 1.80, 95 % CI: 1.27-2.54), and BADL from non-limitation to limitation (HR: 1.86, 95 % CI: 1.62-2.14) were each experienced a higher risk of CVD compared with those with persistent BADL non-limitation. Of all the items of BADL, limitation of bathing or multiple BADL limitations (≥2) was positively associated with the risk of stroke.

Conclusion: Longitudinally persistent BADL limitation was associated with a more than twofold risk of CVD in later life among the Chinese older adults. Similar but slightly weak association was also observed for temporary BADL limitation. Older adults with BADL limitation, especially those with bathing limitation or with multiple functional limitations, should be the target population for CVD prevention.