Nutrition Metabolism and Cardiovascular Diseases最新文献_第5页

Causal relationships of lipid metabolism in diabetic nephropathy risk: A two-sample Mendelian randomization study 脂质代谢与糖尿病肾病风险的因果关系：一项双样本孟德尔随机化研究。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.numecd.2025.104528

Cui Yu , Houwen Zhang , Feizhen Ni , Lu Jin , Zhimin Ying , Huiying Fu , Qiyang Shou

Background and aim

Diabetic nephropathy (DN) represents the primary contributor to end-stage renal disease worldwide, and its prevalence continues to grow, even with improvements in therapies aimed at lowering glucose levels. The progression of DN has been associated with lipid metabolism, yet the direct involvement of particular lipid species is still not fully understood. This study employs two-sample Mendelian randomization (TSMR) to investigate the causal effects of 179 plasma lipid species on DN risk.

Methods and results

Lipid exposure genetic instruments were sourced from a genome-wide association study (GWAS) found in the GWAS Catalog, whereas data on the DN outcomes were collected from the FinnGen R12 cohort. The main analytical approach employed was inverse-variance weighted (IVW) regression. To evaluate pleiotropy and heterogeneity, tests such as MR-Egger intercept, Cochran's Q, MR-PRESSO, and leave-one-out analyses were performed. The analysis identified 13 lipid species with significant associations after sensitivity analyses. Among these, seven lipid species were risk factors for DN, including phosphatidylcholine (PC) (O-16:1_18:1, 15:0_18:2, 18:1_18:1, 18:1_20:2, 18:2_18:2) levels, phosphatidylethanolamine (PE) (18:1_18:1), and triacylglycerol (TAG) (56:4). Conversely, six lipid species demonstrated protective effects, including lysophosphatidylcholine (LPC) (20:4), lysophosphatidylethanolamine (LPE) (18:1), PC (17:0_20:4), sterol ester (SE) (27:1/15:0, 27:1/18:3), and TAG (52:6).

Conclusions

This study provides robust genetic evidence linking specific lipid species to DN risk. PC and PE species were identified as risk factors, whereas LPC, LPE, and SE exhibited protective effects. Additionally, TAG species demonstrated a bidirectional influence. These findings refine the understanding of lipid-mediated renal dysfunction in DN, highlighting lipid metabolism as a potential therapeutic target.

背景和目的：糖尿病肾病（DN）是世界范围内终末期肾脏疾病的主要诱因，即使降低血糖水平的治疗方法有所改善，其患病率仍在持续增长。DN的进展与脂质代谢有关，但具体脂质种类的直接参与尚不完全清楚。本研究采用双样本孟德尔随机化（TSMR）研究179种血脂对DN风险的因果关系。方法和结果：脂质暴露遗传仪器来自GWAS目录中的全基因组关联研究（GWAS），而DN结果的数据来自FinnGen R12队列。采用的主要分析方法是逆方差加权回归。为了评估多效性和异质性，进行了MR-Egger截距、科克伦Q值、MR-PRESSO和留一分析等检验。通过敏感性分析，该分析确定了13种脂质具有显著相关性。其中，磷脂酰胆碱（PC）（o: 16:1_18 . 1,15:0 _18 . 2,18:1_18 . 1,18:1_20 . 2,18:2 _18 . 2）、磷脂酰乙醇胺（PE）（18:1_18 . 1）和甘油三酯（TAG）（56:4）是DN的危险因素。相反，6种脂质表现出保护作用，包括溶血磷脂酰胆碱（LPC）（20:4），溶血磷脂酰乙醇胺（LPE）（18:1）， PC(17:0 ~ 20:4)，甾醇酯（SE）（27:1/15:0, 27:1/18:3）和TAG（52:6）。结论：本研究提供了将特定脂质物种与DN风险联系起来的强有力的遗传证据。PC和PE是危险因素，而LPC、LPE和SE具有保护作用。此外，TAG物种表现出双向影响。这些发现完善了对DN中脂质介导的肾功能障碍的理解，突出了脂质代谢作为潜在的治疗靶点。

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引用次数: 0

The association of obesity and other metabolic disorders with COVID-19 mortality: a cross-sectional analysis of death certificates from Veneto (Italy) and Bavaria (Germany) 肥胖和其他代谢紊乱与COVID-19死亡率的关联：对威尼托（意大利）和巴伐利亚（德国）死亡证明的横断面分析。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-13 DOI: 10.1016/j.numecd.2025.104524

Andrea Buschner , Ugo Fedeli , Giacomo Zoppini

Background and aim

The study investigates mortality related to obesity and other metabolic disorders during the pandemic, comparing findings from two large European regions.

Methods and results

All death certificates of residents aged 45–84 years in Veneto (Italy) and Bavaria (Germany) were extracted from January 2020 to December 2022. The proportion of deaths reporting obesity, diabetes, and hypertension was computed both for all-cause and for COVID-19 deaths. The prevalence of mention of metabolic disorders was compared between deaths attributed to COVID-19 and all other deaths by means of Odds Ratios (OR) with 95 % Confidence Intervals (CI) estimated by conditional logistic regression stratified by age, sex, and year of death.

Overall 81,125 deaths in Veneto (8.5 % attributed to COVID-19) and 253,862 in Bavaria (5.9 % from COVID-19) were investigated. At least one metabolic disorder was mentioned in 35.8 % of all COVID-19 deaths in Veneto and 26.7 % in Bavaria. Obesity-related deaths sharply peaked in each epidemic wave in both regions, with a less marked pattern for hypertensive diseases and diabetes. The association with COVID-19 increased with the number of reported metabolic disorders, was stronger among younger ages and in Veneto. Estimated OR for COVID-19 death among decedents aged 45–64 years with two/three vs. no metabolic disorder were 4.24 (CI 3.33–5.40) in Veneto and 2.14 (1.83–2.51) in Bavaria.

Conclusion

The strong association between deaths from COVID-19 and number of metabolic disorders among younger ages highlights the need for prioritizing preventive interventions for obesity and associated metabolic conditions.

背景和目的：该研究调查了大流行期间与肥胖和其他代谢紊乱相关的死亡率，比较了欧洲两个大地区的研究结果。方法与结果：提取2020年1月至2022年12月意大利威尼托州和德国巴伐利亚州45-84岁居民的死亡证明。计算了报告肥胖、糖尿病和高血压的死亡比例，包括全因死亡和COVID-19死亡。通过比值比（OR）比较由COVID-19引起的死亡与所有其他死亡之间提及代谢紊乱的患病率，并通过按年龄、性别和死亡年份分层的条件logistic回归估计95%的置信区间（CI）。威尼托共有81125人死亡（8.5%归因于COVID-19），巴伐利亚共有253862人死亡（5.9%归因于COVID-19）。威尼托州35.8%的COVID-19死亡病例和巴伐利亚州26.7%的死亡病例中至少有一种代谢紊乱。在这两个地区，与肥胖相关的死亡人数在每次流行病浪潮中都达到高峰，高血压疾病和糖尿病的模式不太明显。与COVID-19的关联随着报告的代谢紊乱数量的增加而增加，在年轻人和威尼托地区更为明显。威尼托州45-64岁伴有2 / 3代谢紊乱与无代谢紊乱的死者中COVID-19死亡的估计OR为4.24 (CI 3.33-5.40)，巴伐利亚州为2.14 （CI 1.83-2.51）。结论：COVID-19导致的死亡与年轻人中代谢紊乱的数量之间存在密切关联，这突出表明需要优先考虑对肥胖和相关代谢疾病进行预防性干预。

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引用次数: 0

Pro‐ and Anti‐Inflammatory properties of neutrophils and CRP: Some points for consideration 中性粒细胞和CRP的促炎和抗炎特性：一些值得考虑的问题。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-04 DOI: 10.1016/j.numecd.2025.104512

Zohreh Jadali

引用次数: 0

Omega-3 fatty acids and cardiovascular risk-related metabolic markers in diverse populations: a meta-analysis of randomized trials 不同人群中Omega-3脂肪酸和心血管风险相关代谢标志物：随机试验的荟萃分析

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-03 DOI: 10.1016/j.numecd.2025.104488

Chen Chen , Xuan Li , Hongli Yan , Junyan Liu , Yuhang Cao , Hongjiao Zhao , Shixin Liu , Yilin Wang , Yifei Sun , Beili Jia , Junhua Yuan

Aim

Many studies reported the effects of n-3 polyunsaturated fatty acids (PUFA) towards cardiovascular risk, but results are inconclusive. This meta-analysis systemically explored PUFA-mediated effects on representative cardiovascular-related metabolic markers, including glycolipid profile, adiponectin, and oxidative stress indicators in different people.

Data synthesis

Literature search on PubMed, EMBASE, Web of Science, and the Cochrane Library were performed up to October 11, 2024. Randomized controlled trials focusing on the effects of n-3 PUFA supplementation on triacylglycerol (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), apolipoprotein, adipokine, hemoglobin A1c (HbA1c), c-reactive protein (CRP), and oxidative stress biomarkers were chosen as outcome variables. There were 24 studies with 2043 subjects showed significant effects: (1)TG decreased by 16.95 mg/dl (21 trials, n = 1491; 95 % CI: 23.25, −10.66), (2)HDL increased by 1.55 mg/dl (22 trials, n = 1914; 95 % CI: 0.69, 2.42), (3)adiponectin increased by 0.96 μg/ml (3 trials, n = 198; 95 % CI: 0.03, 1.8), (4)HbA1c decreased by 0.17 % (3 trials, n = 283; 95 % CI: 0.29, −0.04), (5)LDL decreased by 10.98 mg/dl in women (4 trials, n = 236; 95 % CI: 19.41, −2.5) and by 13.77 mg/dl in the polycystic ovary syndrome (PCOS) (3 trials, n = 180; 95 % CI: 22.83, −4.7), (6)TC decreased by 15.58 mg/dl in women (4 trials, n = 236; 95 % CI: 24.64, −6.53).

Conclusions

The meta-analysis indicates that n-3 PUFAs improve cardiovascular-related metabolic markers, potentially benefit cardiovascular health in patients with cardiovascular disease, PCOS, and kidney disease, especially in older women via reducing TG and HbA1c and increasing HDL and adiponectin.

目的：许多研究报道了n-3多不饱和脂肪酸（PUFA）对心血管风险的影响，但结果尚无定论。本荟萃分析系统地探讨了pufa对不同人群中具有代表性的心血管相关代谢指标的影响，包括糖脂谱、脂联素和氧化应激指标。数据综合：截至2024年10月11日，在PubMed、EMBASE、Web of Science和Cochrane Library上进行文献检索。选择n-3 PUFA补充对甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、总胆固醇（TC）、载脂蛋白、脂肪因子、血红蛋白A1c （HbA1c）、c反应蛋白（CRP）和氧化应激生物标志物的影响的随机对照试验作为结果变量。有24与2043名受试者的研究显示显著效果:(1)TG下降了16.95 mg / dl(21试验,n = 1491; 95%置信区间:23.25,-10.66),(2)HDL增加1.55 mg / dl(22试验,n = 1914; 95%置信区间:0.69,2.42),(3)脂联素增加了0.96μg / ml(3试验,n = 198; 95%置信区间CI: 0.03, 1.8),(4)糖化血红蛋白下降了0.17%(3试验,n = 283; 95%置信区间CI: 0.29, -0.04),(5)低密度脂蛋白下降了10.98 mg / dl女性(4试验,n = 236;95% CI: 19.41, -2.5)，在多囊卵巢综合征（PCOS）中降低13.77 mg/dl(3项试验，n = 180; 95% CI: 22.83, -4.7),(6)女性TC降低15.58 mg/dl（4项试验，n = 236; 95% CI: 24.64, -6.53）。结论：荟萃分析表明，n-3 PUFAs可改善心血管相关代谢标志物，通过降低TG和HbA1c，增加HDL和脂联素，对心血管疾病、多囊卵巢综合征和肾脏疾病患者，尤其是老年女性的心血管健康有潜在益处。

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引用次数: 0

The association between oils and fats consumption and the risk of premature coronary artery disease in a multi-centric case-control study: Iran premature coronary artery (IPAD) 一项多中心病例对照研究：伊朗过早冠状动脉（IPAD）：油脂消耗与过早冠状动脉疾病风险之间的关系

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-05 DOI: 10.1016/j.numecd.2025.104516

Bahar Darouei , Faezeh Tabesh , Reza Amani-Beni , Fatemeh Nouri , Ehsan Zarepur , Masoumeh Sadeghi , Noushin Mohammadifard , Nizal Sarrafzadegan

Background and aims

The impact of different dietary fats on premature coronary artery disease (PCAD) has not been well established. Given Iran's ethnic diversity, this study examined the association between fat intake and the risk and severity of PCAD in multiple Iranian ethnicities.

Methods and results

In this multicenter case-control study, men aged <55 and women aged <65 years who were candidates for coronary angiography were recruited from major Iranian ethnicities. Intake of hydrogenated vegetable oil (HVO), non-hydrogenated vegetable oil (non-HVO), animal fat, and a composite fat consumption index (FCI) was assessed using a validated food frequency questionnaire and dichotomized at the median. Logistic regression models were fitted in three steps: crude, age- and sex-adjusted, and multivariate-adjusted. A total of 2459 participants were included: 1395 with PCAD and 1064 controls. The mean age was 51.47 ± 7.24. A higher non-HVO intake was associated with a lower risk of PCAD in the fully adjusted model (odds ratio [OR]: 0.37; 95 % confidence interval [CI]: 0.29, 0.46). This pattern was similar in the Fars (OR = 0.31), Kurdish (OR = 0.26), Bakhtiari (OR = 0.28), and Qashqaei (OR = 0.24) groups but not in the Azari group. Non-HVO intake was also associated with lower PCAD severity (OR: 0.31; 95 %CI 0.26, 0.37). No significant associations were observed between HVO, animal fat, or FCI. The interaction tests did not show any meaningful ethnic modifications.

Conclusions

Replacing solid and hydrogenated fats with liquid nonhydrogenated vegetable oils may reduce both the risk and severity of PCAD in Iranian adults and support dietary advice that prioritizes fat quality.

背景和目的：不同膳食脂肪对过早冠状动脉疾病（PCAD）的影响尚未得到很好的确定。鉴于伊朗的民族多样性，本研究调查了伊朗多个民族中脂肪摄入量与pad风险和严重程度之间的关系。结论：用液体非氢化植物油替代固体和氢化脂肪可能降低伊朗成年人PCAD的风险和严重程度，并支持优先考虑脂肪质量的饮食建议。

{"title":"The association between oils and fats consumption and the risk of premature coronary artery disease in a multi-centric case-control study: Iran premature coronary artery (IPAD)","authors":"Bahar Darouei , Faezeh Tabesh , Reza Amani-Beni , Fatemeh Nouri , Ehsan Zarepur , Masoumeh Sadeghi , Noushin Mohammadifard , Nizal Sarrafzadegan","doi":"10.1016/j.numecd.2025.104516","DOIUrl":"10.1016/j.numecd.2025.104516","url":null,"abstract":"<div><h3>Background and aims</h3><div>The impact of different dietary fats on premature coronary artery disease (PCAD) has not been well established. Given Iran's ethnic diversity, this study examined the association between fat intake and the risk and severity of PCAD in multiple Iranian ethnicities.</div></div><div><h3>Methods and results</h3><div>In this multicenter case-control study, men aged <55 and women aged <65 years who were candidates for coronary angiography were recruited from major Iranian ethnicities. Intake of hydrogenated vegetable oil (HVO), non-hydrogenated vegetable oil (non-HVO), animal fat, and a composite fat consumption index (FCI) was assessed using a validated food frequency questionnaire and dichotomized at the median. Logistic regression models were fitted in three steps: crude, age- and sex-adjusted, and multivariate-adjusted. A total of 2459 participants were included: 1395 with PCAD and 1064 controls. The mean age was 51.47 ± 7.24. A higher non-HVO intake was associated with a lower risk of PCAD in the fully adjusted model (odds ratio [OR]: 0.37; 95 % confidence interval [CI]: 0.29, 0.46). This pattern was similar in the Fars (OR = 0.31), Kurdish (OR = 0.26), Bakhtiari (OR = 0.28), and Qashqaei (OR = 0.24) groups but not in the Azari group. Non-HVO intake was also associated with lower PCAD severity (OR: 0.31; 95 %CI 0.26, 0.37). No significant associations were observed between HVO, animal fat, or FCI. The interaction tests did not show any meaningful ethnic modifications.</div></div><div><h3>Conclusions</h3><div>Replacing solid and hydrogenated fats with liquid nonhydrogenated vegetable oils may reduce both the risk and severity of PCAD in Iranian adults and support dietary advice that prioritizes fat quality.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 4","pages":"Article 104516"},"PeriodicalIF":3.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reframing the drivers of obesity: Integrating commercial determinants and metabolic diversity into post-pharmacotherapy strategies 重塑肥胖的驱动因素：将商业决定因素和代谢多样性整合到药物治疗后的策略中。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-11-27 DOI: 10.1016/j.numecd.2025.104480

Chutharat Thanchonnang , Schawanya K. Rattanapitoon , Patpicha Arunsan , Nathkapach K. Rattanapitoon

引用次数: 0

Caffeine metabolic phenotypes and hypertension risk: Urinary paraxanthine-to-caffeine ratio threshold and mediating pathways in NHANES 咖啡因代谢表型和高血压风险：NHANES中尿副黄嘌呤与咖啡因比例阈值和介导途径。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-17 DOI: 10.1016/j.numecd.2025.104525

Fang-e Shi , Zhengyi Huang , Lingjie Cao , Zhe Yu , Cheng Chi

Background and aims

This study aimed to resolve the caffeine-hypertension paradox by investigating the association between urinary paraxanthine-to-caffeine molar ratio (PMR)—a functional biomarker of CYP1A2 metabolic capacity—and hypertension risk, while exploring mediation by serum uric acid (SUA) and white blood cells (WBC).

Methods and results

Using nationally representative NHANES data (2009–2014; n = 1611), urinary PMR was quantified via UPLC-ESI-MS/MS. Hypertension was defined per AHA/ACC 2017 guidelines. Multivariable logistic regression analyzed PMR-hypertension associations (unadjusted, age/sex-adjusted, fully adjusted). Dose-response relationships were modeled using restricted cubic spline (RCS) analysis. Causal mediation tested SUA/WBC pathways. Faster caffeine metabolism (higher PMR) demonstrated a nonlinear inverse relationship with hypertension. A critical inflection point at PMR = 3.03 revealed: slow metabolizers (PMR <3.03) had 51 % higher hypertension risk than fast metabolizers (OR = 0.49, 95 % CI: 0.40–0.60; P < 0.001). SUA and WBC collectively mediated 12 % of PMR's protective effect (SUA: 8.0 %; WBC: 4.0 %). Subgroup analyses showed effect modification by age and race (P interaction <0.05).

Conclusion

PMR serves as a novel biomarker clarifying the caffeine-hypertension paradox: fast metabolizers (PMR ≥3.03) exhibit significantly reduced hypertension risk, partially mediated by reduced SUA and inflammation. This supports personalized caffeine intake recommendations based on metabolic phenotype.

背景和目的：本研究旨在通过研究尿对黄嘌呤与咖啡因摩尔比（PMR）（CYP1A2代谢能力的功能性生物标志物）与高血压风险之间的关系，同时探索血清尿酸（SUA）和白细胞（WBC）的中介作用，来解决咖啡因与高血压的矛盾。方法与结果：采用具有全国代表性的NHANES数据（2009-2014;n = 1611），采用UPLC-ESI-MS/MS对尿液PMR进行定量。根据AHA/ACC 2017指南定义高血压。多变量logistic回归分析pmr与高血压的关系（未调整、年龄/性别调整、完全调整）。剂量-反应关系采用限制性三次样条（RCS）分析建模。因果中介检验了SUA/WBC通路。更快的咖啡因代谢（更高的PMR）与高血压呈非线性反比关系。结论：PMR作为一种新的生物标志物澄清了咖啡因-高血压悖论：快速代谢者（PMR≥3.03）表现出显著降低的高血压风险，部分原因是SUA和炎症的减少。这支持了基于代谢表型的个性化咖啡因摄入量建议。

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引用次数: 0

Longitudinal associations between fast food outlet count and inflammatory markers in the US-based nurses’ health study II between 1998 and 2011 1998年至2011年美国护士健康研究II中快餐店数量与炎症标志物之间的纵向关联。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-11-27 DOI: 10.1016/j.numecd.2025.104476

Noreen Z. Siddiqui , Joline W.J. Beulens , Jaime E. Hart , Jochem O. Klompmaker , Joreintje D. Mackenbach , Maria G.M. Pinho , Eric B. Rimm , Peter James

Background and aims

Inflammation is an established cardiovascular disease risk factor, but its role in the link between food environments and cardiovascular risk remains unexplored.

We aimed to study longitudinal associations between residential fast food outlets (FFOs) and inflammatory markers in US females from the Nurses’ Health Study II with stored blood and residential addresses.

Methods and results

We counted FFOs within 1500-m buffers around each address in 1998 and 2010. In samples collected at two time points (1999, 2011), we measured C-reactive protein (CRP, N = 1350), Interleukin-6 (IL-6, N = 809), and adiponectin (N = 836). We performed multivariable linear regression with repeated measures to study changes in FFOs and inflammatory markers and multivariable linear regression analyses to study FFOs count in 1998 and changes in inflammatory markers between 1999 and 2011. Models were adjusted for age, race/ethnicity, partners’ education, smoking, neighborhood socioeconomic status (nSES), and population density. We explored effect modification by nSES and population density. No associations were observed in linear mixed models (e.g., CRP (β: 0.00, 95 %CI: 0.01,0.01) or in linear models including changes in inflammatory outcomes (e.g., CRP (β:0.00, 95 %CI: 0.01, 0.02). We also observed no effect modification for nSES or population density.

Conclusion

In conclusion, we found no evidence for longitudinal associations between FFOs count and inflammatory markers in this study.

背景和目的：炎症是一种确定的心血管疾病危险因素，但其在食物环境和心血管风险之间的联系中的作用仍未被探索。我们的目的是研究住宅快餐店（ffo）与美国女性炎症标志物之间的纵向关联，这些女性来自护士健康研究II，储存血液和居住地址。方法与结果：我们在1998年和2010年对每个地址周围1500米缓冲区内的ffo进行了统计。在两个时间点（1999年、2011年）采集的样本中，我们测量了c反应蛋白（CRP, N = 1350）、白细胞介素-6 （IL-6, N = 809）和脂联素（N = 836）。我们采用重复测量的多变量线性回归来研究ffo和炎症标志物的变化，并采用多变量线性回归分析来研究1998年ffo计数和1999年至2011年炎症标志物的变化。模型根据年龄、种族/民族、伴侣教育程度、吸烟、社区社会经济地位（nSES）和人口密度进行了调整。研究了nSES和人口密度对效应的影响。在线性混合模型(例如，CRP （β:0.00, 95% CI: 0.01,0.01）或包括炎症结果变化的线性模型(例如，CRP （β:0.00, 95% CI: 0.01, 0.02）中未观察到相关性。我们也没有观察到nSES或种群密度的效应改变。结论：在本研究中，我们没有发现ffo计数与炎症标志物之间存在纵向关联的证据。

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引用次数: 0

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-11-28 DOI: 10.1016/j.numecd.2025.104478

Claudia R.L. Cardoso, Cristiane A. Villela-Nogueira, Gil F. Salles, Nathalie C. Leite

Background and aim

Reduction in liver fibrosis, as assessed by liver stiffness measurement (LSM) on serial vibration-controlled transient elastography (VCTE) examinations, may have beneficial effects on development of liver-related and cardiovascular outcomes in individuals with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods and results

A prospective cohort of 288 individuals with type 2 diabetes and MASLD performed 2 VCTE exams at least two years apart, and significant LSM reduction was defined as >20 % decrease. Logistic regression assessed the independent correlates of having LSM reduction and multivariable Cox analyses assessed associations between LSM reduction and liver-related and cardiovascular outcomes.

Eighty-six individuals (30 %) had a reduction in LSM >20 %; its independent correlates were a lower aspartate aminotransferase (AST ≤20 U/L) and HbA_1c (≤7 %) levels closest to the 2nd VCTE exam, the use of statins and having the wild CC genotype of the PNPLA3 gene. Over a median follow-up of 6 years, there were 22 liver-related and 28 cardiovascular events. Reduction in LSM was associated with a significant 78 % lower risk of liver events and 62 % lower cardiovascular risk.

Conclusions

Using statins and achieving good glycemic control are associated with higher chances of having liver fibrosis reduction, and serum AST reduction may be a biomarker of such improvement. Having LSM reduction on serial VCTE examinations is associated with lower risks of adverse cardiovascular and liver-related events and, if further confirmed, it might be a treatment goal in individuals with type 2 diabetes and MASLD.

背景和目的：通过连续振动控制瞬时弹性成像（VCTE）检查中的肝刚度测量（LSM）评估，肝纤维化的减少可能对2型糖尿病和代谢功能障碍相关脂肪变性肝病（MASLD）患者肝脏相关和心血管结局的发展有有益影响。方法和结果：288例2型糖尿病和MASLD患者进行了两次VCTE检查，间隔至少两年，LSM显著降低定义为下降20%。Logistic回归评估LSM降低的独立相关性，多变量Cox分析评估LSM降低与肝脏相关和心血管结局之间的相关性。86人（30%）LSM下降20%；其独立的相关因素为：与第二次VCTE检查相近的较低的天冬氨酸转氨酶（AST≤20 U/L）和HbA1c（≤7%）水平、他汀类药物的使用以及PNPLA3基因为野生CC基因型。在中位6年的随访中，有22例肝脏相关事件和28例心血管事件。LSM的减少与肝脏事件风险显著降低78%和心血管风险显著降低62%相关。结论：使用他汀类药物并实现良好的血糖控制与肝纤维化减少的可能性较高相关，血清AST降低可能是这种改善的生物标志物。连续VCTE检查中LSM降低与心血管和肝脏相关不良事件的风险降低相关，如果进一步证实，这可能是2型糖尿病和MASLD患者的治疗目标。

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引用次数: 0

High atherogenic index of plasma increased the risk of new-onset hypertension 血浆的高动脉粥样硬化指数增加了新发高血压的风险。

IF 3.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2026-04-01 Epub Date: 2025-12-02 DOI: 10.1016/j.numecd.2025.104486

Zhong-Yuan Meng , Sen-Hu Tang , Lan-Xian Mai , Chuang-Hong Lu , Jing Li , Jia-Ping Li , Sheng-Lin Xian , Zhi-Yu Zeng

Background and aim

The atherogenic index of plasma (AIP), calculated as log10 (triglyceride/high-density lipoprotein cholesterol, TG/HDL-C), has been proposed as a reliable marker for evaluating lipid-related atherosclerotic risk. However, the association between AIP and new-onset hypertension (HTN) remains controversial. This study aimed to investigate the relationship between AIP and new-onset HTN and to explore the potential mediating role of body mass index (BMI).

Methods and results

This prospective cohort study included adult participants without HTN at baseline who were enrolled from a large community-based health screening program between 2014 and 2023. Baseline clinical characteristics, anthropometric parameters, and biochemical indices were collected. Restricted cubic spline (RCS) analysis was used to determine the inflection point of AIP for grouping participants into low- and high-AIP categories. Propensity score matching (PSM) was applied to balance baseline confounders between groups. The cumulative incidence of HTN was compared using cumulative risk curves and log-rank tests. Multivariate Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Mediation analysis was performed to assess whether BMI mediated the relationship between AIP and new-onset HTN. The results showed participants with higher baseline or cumulative AIP values had a significantly higher risk of developing HTN (log-rank p < 0.001). After multivariable adjustment, individuals in the high-AIP group exhibited an elevated risk of new-onset HTN (HR = 1.42, 95 % CI 1.25–1.61, p < 0.001) compared with those in the low-AIP group. BMI partially mediated the association between AIP and HTN, accounting for approximately 5.76 % of the total effect (p < 0.001).

Conclusions

A high AIP increased the risk of new HTN. BMI potentially mediated the association between the AIP and new-onset HTN.

背景与目的：血浆动脉粥样硬化指数（AIP）以log10（甘油三酯/高密度脂蛋白胆固醇，TG/HDL-C）计算，已被提出作为评估脂质相关动脉粥样硬化风险的可靠标志物。然而，AIP与新发高血压（HTN）之间的关系仍存在争议。本研究旨在探讨AIP与新发HTN的关系，并探讨体重指数（BMI）可能在其中的中介作用。方法和结果：这项前瞻性队列研究纳入了2014年至2023年间从大型社区健康筛查项目中招募的基线时无HTN的成年参与者。收集基线临床特征、人体测量参数和生化指标。使用限制性三次样条（RCS）分析确定AIP的拐点，将参与者分为低AIP和高AIP类别。使用倾向评分匹配（PSM）来平衡组间的基线混杂因素。采用累积风险曲线和log-rank检验比较HTN的累积发生率。采用多变量Cox比例风险模型估计风险比（hr）和95%置信区间（ci）。通过中介分析评估BMI是否介导AIP与新发HTN之间的关系。结果显示，基线或累积AIP值较高的参与者发生HTN的风险明显更高（log-rank p）。结论：高AIP增加了新HTN的风险。BMI可能介导AIP与新发HTN之间的关联。

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