Pub Date : 2025-12-17DOI: 10.1016/j.numecd.2025.104530
Shiru Chen, Jijuan Zhang, Hancheng Yu, Si Xiong, Yuchong Zhao, Shuya Bai, Jiamei Jiang, An Pan, Bin Cheng
Background and aims: Little is known about the relationships between lipoprotein subclasses and the risk of cardiovascular disease (CVD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). We sought to elucidate the associations of lipoprotein subclasses with the risk of CVD in individuals with MASLD.
Methods and results: This study included 51,472 individuals with MASLD from the UK biobank. Concentrations of lipoprotein subclasses were quantified by nuclear magnetic resonance. Multivariable-adjusted Cox proportional hazards model was used to evaluate the associations between lipoprotein subclasses and the incidence/mortality of CVD. During median follow-ups of 13.3-13.5 years, 6208 incident CVD cases, 5206 coronary heart disease cases, 1270 stroke cases, and 559 CVD-related deaths were documented. Most very-low-density lipoprotein (VLDL) [hazard ratio (HR) range: 1.03-1.13; P <0.05], intermediate-density lipoprotein (HR range: 1.08-1.11; P <0.05), low-density lipoprotein (HR range: 1.05-1.11; P <0.05), very large high-density lipoprotein (HDL) particles and triglycerides in small HDL subclasses (HR range: 1.04-1.16; P <0.05) were positively associated with the risk of incident CVD, whereas other HDL particles and their subclasses were related to reduced risks of incident CVD (HR range: 0.86-0.95; P <0.05). Moreover, the association of VLDL particles with CVD strengthened as the diameter of VLDL decreased.
Conclusion: These findings suggest that associations between lipoprotein subclasses and the risk of CVD differed by particle diameter in individuals with MASLD. Integrating lipoprotein subclass assessment into clinical management and promoting subclass‑targeted lipid‑lowering strategies may strengthen CVD prevention in MASLD.
{"title":"Associations of lipoprotein subclasses with risk of cardiovascular disease in individuals with MASLD.","authors":"Shiru Chen, Jijuan Zhang, Hancheng Yu, Si Xiong, Yuchong Zhao, Shuya Bai, Jiamei Jiang, An Pan, Bin Cheng","doi":"10.1016/j.numecd.2025.104530","DOIUrl":"https://doi.org/10.1016/j.numecd.2025.104530","url":null,"abstract":"<p><strong>Background and aims: </strong>Little is known about the relationships between lipoprotein subclasses and the risk of cardiovascular disease (CVD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). We sought to elucidate the associations of lipoprotein subclasses with the risk of CVD in individuals with MASLD.</p><p><strong>Methods and results: </strong>This study included 51,472 individuals with MASLD from the UK biobank. Concentrations of lipoprotein subclasses were quantified by nuclear magnetic resonance. Multivariable-adjusted Cox proportional hazards model was used to evaluate the associations between lipoprotein subclasses and the incidence/mortality of CVD. During median follow-ups of 13.3-13.5 years, 6208 incident CVD cases, 5206 coronary heart disease cases, 1270 stroke cases, and 559 CVD-related deaths were documented. Most very-low-density lipoprotein (VLDL) [hazard ratio (HR) range: 1.03-1.13; P <0.05], intermediate-density lipoprotein (HR range: 1.08-1.11; P <0.05), low-density lipoprotein (HR range: 1.05-1.11; P <0.05), very large high-density lipoprotein (HDL) particles and triglycerides in small HDL subclasses (HR range: 1.04-1.16; P <0.05) were positively associated with the risk of incident CVD, whereas other HDL particles and their subclasses were related to reduced risks of incident CVD (HR range: 0.86-0.95; P <0.05). Moreover, the association of VLDL particles with CVD strengthened as the diameter of VLDL decreased.</p><p><strong>Conclusion: </strong>These findings suggest that associations between lipoprotein subclasses and the risk of CVD differed by particle diameter in individuals with MASLD. Integrating lipoprotein subclass assessment into clinical management and promoting subclass‑targeted lipid‑lowering strategies may strengthen CVD prevention in MASLD.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":"104530"},"PeriodicalIF":3.7,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146120800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104316
A. Oliverio , E. Bruno , C. Meli , A. Daniele , S. Tommasi , D.A. Terribile , S. Magno , A. Filippone , M.M. Rossi , C. Rossi , S. Manoukian , P. Pasanis
{"title":"Impact of a Mediterranean Diet on BRCA-Related Cancer Risk","authors":"A. Oliverio , E. Bruno , C. Meli , A. Daniele , S. Tommasi , D.A. Terribile , S. Magno , A. Filippone , M.M. Rossi , C. Rossi , S. Manoukian , P. Pasanis","doi":"10.1016/j.numecd.2025.104316","DOIUrl":"10.1016/j.numecd.2025.104316","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104316"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104297
E. Ruggiero , A. Di Castelnuovo , S. Costanzo , G. Grosso , T. Panzera , S. Esposito , C. Cerletti , M.B. Donati , G. De Gaetano , L. Iacoviello , M. Bonaccio
{"title":"Adherence to the EAT-Lancet Commission Planetary Health Diet and Cardiovascular Disease Risk in the Moli-sani Study Cohort: a Prospective Study and an Analysis of Biological Pathways","authors":"E. Ruggiero , A. Di Castelnuovo , S. Costanzo , G. Grosso , T. Panzera , S. Esposito , C. Cerletti , M.B. Donati , G. De Gaetano , L. Iacoviello , M. Bonaccio","doi":"10.1016/j.numecd.2025.104297","DOIUrl":"10.1016/j.numecd.2025.104297","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104297"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104327
G. Mercurio , A. Giacco , N. Scopigno , M. Vigliotti , M. Ledbetter , A.D. Troise , S. De Pascale , A. Scaloni , A. Fiore , M. Mazzola , G. Riccio , M. Moreno , F. Cioffi , E. Silvestri
{"title":"Mitochondrial Effects of a Mediterranean Diet-Based Cocktail in the Liver of Diabetic/Obese Mice","authors":"G. Mercurio , A. Giacco , N. Scopigno , M. Vigliotti , M. Ledbetter , A.D. Troise , S. De Pascale , A. Scaloni , A. Fiore , M. Mazzola , G. Riccio , M. Moreno , F. Cioffi , E. Silvestri","doi":"10.1016/j.numecd.2025.104327","DOIUrl":"10.1016/j.numecd.2025.104327","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104327"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104336
L. Chehade, M. Tucci, C. Del Bo', P. Riso, D. Martini
{"title":"Nutritional and Environmental Adequacy of Menus and Meals Served in Institutional Canteens: Findings of a Scoping Review","authors":"L. Chehade, M. Tucci, C. Del Bo', P. Riso, D. Martini","doi":"10.1016/j.numecd.2025.104336","DOIUrl":"10.1016/j.numecd.2025.104336","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104336"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104310
T. Montebugnoli , C. Grootaert , A. Bordoni , A. Rajkovic , E. Alderweireldt , J. Rombaut , S. De Maeseneire , J. Van Camp , M.L. De Mol
{"title":"Metabolic and Structural Impact of Food Iminosugars and Synthetic Derivatives in Colon Cancer Cell Lines","authors":"T. Montebugnoli , C. Grootaert , A. Bordoni , A. Rajkovic , E. Alderweireldt , J. Rombaut , S. De Maeseneire , J. Van Camp , M.L. De Mol","doi":"10.1016/j.numecd.2025.104310","DOIUrl":"10.1016/j.numecd.2025.104310","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104310"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145753977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104320
M. Ferrando , E. Proietti , E. Formisano , C. Borgarelli , M. Borriello , M. Demontis , M. Caviglia , S. Carozzi , M. Dellepiane , P. Fracassi , L. Pisciotta
{"title":"FAO World Food Day in Genoa: Taking Action Through Educational Events and Training Sessions","authors":"M. Ferrando , E. Proietti , E. Formisano , C. Borgarelli , M. Borriello , M. Demontis , M. Caviglia , S. Carozzi , M. Dellepiane , P. Fracassi , L. Pisciotta","doi":"10.1016/j.numecd.2025.104320","DOIUrl":"10.1016/j.numecd.2025.104320","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104320"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104321
G. Carioni , M. Guglielmetti , A. Zinnai , F. Fassio , M. Di Stefano , P. Maisonneuve , S. Dominici , M.S. Facioni , P. Gnagnarella
{"title":"Lactose Intolerance: a Survey to Assess Knowledge in the General Population (SINU-AILI Working Group)","authors":"G. Carioni , M. Guglielmetti , A. Zinnai , F. Fassio , M. Di Stefano , P. Maisonneuve , S. Dominici , M.S. Facioni , P. Gnagnarella","doi":"10.1016/j.numecd.2025.104321","DOIUrl":"10.1016/j.numecd.2025.104321","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104321"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.numecd.2025.104326
M. Moretton , N. Pellegrini , A. Donato , D. Martini
{"title":"The Nutritional Quality of Sauces, Dips and Dressings Sold in Italy: a Critical Analysis of the Sodium Content","authors":"M. Moretton , N. Pellegrini , A. Donato , D. Martini","doi":"10.1016/j.numecd.2025.104326","DOIUrl":"10.1016/j.numecd.2025.104326","url":null,"abstract":"","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"36 1","pages":"Article 104326"},"PeriodicalIF":3.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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