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Clitoral epidermal cyst after excision in an 8-year-old girl: the pivotal role of forensic medicine in the detection and care of female genital mutilation (FGM)-related complications 1例8岁女童阴蒂表皮囊肿切除术后：法医学在女性生殖器切割（FGM）相关并发症检测和护理中的关键作用

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-17 DOI: 10.1016/j.legalmed.2025.102757

Anaïs Du Fayet de la Tour , Quentin Ballouhey , Pierre Raguin , François Paraf

Background

Female genital mutilation (FGM) refers to socio-cultural practices involving the partial or total removal of a woman’s external genitalia for non-medical purposes. These procedures are associated with numerous short- and long-term physical and psychological complications. While such complications are relatively well documented in adults, pediatric cases remain insufficiently reported. Forensic physicians are often the first – and sometimes the only – healthcare providers to detect and document these complications, particularly in asylum contexts.

Case presentation

We report the case of an 8½-year-old Guinean girl with a history of type IIb FGM, examined by a forensic physician during an asylum application. The medico-legal examination revealed a 3 cm mobile mass at the clitoral site, causing pelvic pain and urinary dysfunction. Her father had allegedly threatened to perform a second excision. Protective measures were implemented in coordination with child welfare authorities before surgical intervention, which resulted in complete resection of the clitoral mass. Histopathology confirmed the diagnosis of an epidermoid cyst.

Conclusions

This case underscores the critical role of forensic physicians in identifying rare pediatric complications of FGM and initiating both protective and therapeutic interventions. By enabling surgical treatment and preventing long-term psychological harm, it highlights the integrative function of forensic medicine at the intersection of health, law, and child protection.

背景：女性生殖器切割（FGM）是指为非医疗目的部分或全部切除妇女外生殖器的社会文化习俗。这些手术与许多短期和长期的生理和心理并发症有关。虽然这些并发症在成人中有较好的记录，但儿科病例的报道仍然不足。法医往往是第一个——有时是唯一的——发现和记录这些并发症的医疗保健提供者，特别是在庇护情况下。病例介绍：我们报告了一名8岁半的几内亚女孩，她有IIb型女性生殖器切割史，在庇护申请期间由法医检查。法医学检查发现阴蒂部位有一个3厘米的可移动肿块，引起盆腔疼痛和尿功能障碍。据称，她的父亲曾威胁要进行第二次切除手术。手术前与儿童福利当局协调实施了保护措施，最终完全切除了阴蒂肿块。组织病理学证实为表皮样囊肿。结论：该病例强调了法医在识别罕见的儿童女性生殖器切割并发症和启动保护性和治疗性干预方面的关键作用。通过使手术治疗和预防长期心理伤害成为可能，它突出了法医学在卫生、法律和儿童保护交叉领域的综合功能。

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引用次数: 0

Sudden death due to undiagnosed cardiac metastasis of malignant melanoma revealed by autopsy: a case report 猝死原因不明心脏转移的恶性黑色素瘤尸检显示：1例报告。

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-17 DOI: 10.1016/j.legalmed.2025.102756

Dorra Oualha , Taher Sakly , Oumeima Bouzid , Mariem Bel Hadj , Mejda Zakhama , Ahlem Bellalah , Nidhal Haj Salem

Cardiac metastases from malignant melanoma are rare and often remain undiagnosed until autopsy due to their nonspecific clinical presentation. The case report concerns a woman in her 40 s, with medical history of coeliac disease who presented with a triad of cholestatic jaundice, weight loss and generalised weakness. Acute cardiac symptoms occurred during the patient’s hospitalisation, with dyspnoea and palpitations preceding refractory ventricular arrhythmias and sudden death. Post mortem examination showed extensive metastatic melanoma that included the lungs, liver, spleen, lymph nodes and notably the myocardium and the endocardium. Importantly, no cutaneous or mucosal primary site was identified, classifying this case as melanoma of unknown primary (MUP). The histological and immunohistochemical analysis confirmed the diagnosis. This case report summarises the range of diagnostic issues associated with cardiac metastasis from melanoma, where the clinical presentation can mimic other cardiac pathologies and cause undiagnosed fatal arrhythmias. The findings emphasise the significance of meticulous autopsy and histological examination in elucidating unrecognized cardiac involvement in patients with metastatic melanoma, particularly in MUP.

恶性黑色素瘤的心脏转移是罕见的，由于其非特异性的临床表现，通常在尸检前无法诊断。本病例报告涉及一名40多岁的妇女，有乳糜泻病史，表现为胆汁淤积性黄疸、体重减轻和全身虚弱。患者住院期间出现急性心脏症状，在难治性室性心律失常和猝死之前出现呼吸困难和心悸。尸检显示广泛的转移性黑色素瘤，包括肺、肝、脾、淋巴结，尤其是心肌和心内膜。重要的是，没有发现皮肤或粘膜原发部位，将该病例归类为未知原发黑色素瘤（MUP）。组织学和免疫组织化学分析证实了诊断。本病例报告总结了与黑色素瘤心脏转移相关的诊断问题的范围，其临床表现可以模仿其他心脏病理并导致未确诊的致命性心律失常。研究结果强调了细致的尸检和组织学检查在阐明转移性黑色素瘤（尤其是MUP）患者未被识别的心脏病变中的重要性。

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引用次数: 0

Legal age estimation using developing mandibular third molar roots of various developmental stages in Malaysian population: a CBCT study 利用马来西亚人口不同发育阶段的下颌第三磨牙根进行法定年龄估计：一项CBCT研究

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-11 DOI: 10.1016/j.legalmed.2025.102742

Ghassan Ali Abbas , Rabiah Al-Adawiyah Rahmat , Amir Hazwan Abdul Rahim , Mariam Abdullah , Zuraiza Mohamad Zaini , Muhammad Khan Asif , Arofi Kurniawan , Phrabhakaran Nambiar , Norliza Ibrahim

Impacted mandibular third molars (IMTM) are often excluded from dental age estimation due to limited accessibility and morphological variability. This study aimed to develop an age estimation model based on the apical surface area (ASA) of IMTM roots using cone-beam computed tomography (CBCT). A total of 446 CBCT images of Malaysians aged 15–25 years (243 females, 203 males) from Malay and Chinese ethnicities were retrospectively analyzed. ASA measurements were obtained using Mimics and 3-matic software (Materialise NV, Belgium). Impaction levels were classified via a modified Pell and Gregory system, and impaction types using Quek’s modification of Winter’s classification. IMTM angulation, root number, and orientation across three planes were assessed. ASA means were compared by sex and ethnicity using t-tests, and ANOVA was used to evaluate differences across impaction levels, types, and root numbers. General linear regression was applied to identify significant predictors of chronological age and to develop the model, which was validated using an additional 123 CBCT scans. ASA showed a strong inverse correlation with age (r = –0.73). Significant sex-based differences in ASA were observed (male: p = 0.02; female: p = 0.03), with no significant differences between ethnicities. ASA, sex, number of roots, and impaction type were significant predictors of age. The model achieved an R² of 0.607 and mean absolute error ranging from 0.85 to 4.87 years across age groups. This study underscores the use of IMTM from CBCT data as a feasible method for legal age estimation in the Malaysian population, particularly in distinguishing juveniles from adults.

下颌阻生第三磨牙（IMTM）通常被排除在牙龄估计之外，因为其可及性和形态的可变性有限。本研究旨在利用锥形束计算机断层扫描（CBCT）建立一种基于IMTM根根尖表面积（ASA）的年龄估计模型。回顾性分析了马来族和华人15-25岁马来西亚人（243名女性，203名男性）共446张CBCT图像。ASA测量使用Mimics和3-matic软件（Materialise NV，比利时）获得。撞击等级通过改进的Pell和Gregory系统进行分类，撞击类型使用Quek对Winter分类的修改。评估IMTM成角、根数和三个平面的方向。使用t检验比较性别和种族的ASA平均值，并使用方差分析评估影响水平、类型和根数之间的差异。一般线性回归应用于确定实足年龄的重要预测因素并建立模型，并使用额外的123次CBCT扫描验证该模型。ASA与年龄呈显著负相关（r = -0.73）。ASA存在显著的性别差异（男性：p = 0.02；女性：p = 0.03），种族间无显著差异。ASA、性别、根数和嵌塞类型是年龄的显著预测因子。模型在各年龄组间的R2为0.607，平均绝对误差为0.85 ~ 4.87岁。这项研究强调使用来自CBCT数据的IMTM作为马来西亚人口法定年龄估计的可行方法，特别是在区分青少年和成年人方面。

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引用次数: 0

Formalin pigment artifact in postmortem histology: Challenges and potential implications for accurate forensic differential diagnosis 死后组织学中的福尔马林色素伪影：对准确法医鉴别诊断的挑战和潜在影响。

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-11 DOI: 10.1016/j.legalmed.2025.102746

Stefano Tambuzzi , Guendalina Gentile , Lorena Ferraroli, Salvatore Andreola, Riccardo Zoja

Formalin pigment is the most important artifact found in postmortem histological analyses. Although it has no forensic value, formalin pigment, when abundant or not well-known to the pathologist, can morphologically resemble, mimic or misinterpret physiological or exogenous pigments of forensic interest, making their identification challenging and leading to diagnostic difficulties. To investigate these aspects, a retrospective study was conducted on 35 autopsied bodies in various states of preservation in which postmortem histological analyses had revealed the presence of brown/blackish precipitates requiring a differential diagnosis with formalin pigment artifacts. In 29 cases (83%) it could be proven that the precipitates were not due to formalin artifacts. In some cases, however, they were of minor forensic significance, so that others could be categorised as highly forensically significant. These were mainly haemosiderin, lead from gunshot residue (GSR), granular precipitates as a result of acute poisoning with various substances and malaria pigment.

It should therefore be noted that precipitates that can be superficially assigned to formalin artifacts can conceal a multitude of pigments of different types, aetiologies and thus forensic significance, which also depend on the circumstantial and investigative context of the individual cases. For this very reason, it is of central importance for forensic pathologists to constantly question whether it may be useful to further investigate the diagnosis of suspected artifactual formalin pigment precipitates in autopsy specimens.

福尔马林色素是在死后组织学分析中发现的最重要的人工制品。虽然福尔马林色素没有法医价值，但当病理学家不知道它含量丰富时，它可以在形态上类似、模仿或误解法医感兴趣的生理或外源性色素，使其鉴定具有挑战性并导致诊断困难。为了研究这些方面，对35具尸体进行了回顾性研究，这些尸体在不同的保存状态下进行了尸检组织学分析，发现存在棕色/黑色沉淀，需要与福尔马林色素假物进行鉴别诊断。在29例（83%）中，可以证明沉淀不是由福尔马林人为物引起的。但是，在某些情况下，它们在法医上的意义不大，因此其他情况可以归类为具有高度法医意义。这些主要是血黄素、枪弹残留物（GSR）中的铅、各种物质急性中毒造成的颗粒沉淀物和疟疾色素。因此，应该指出的是，表面上被认为是福尔马林文物的沉淀物可能隐藏了多种不同类型的色素、病因和法医意义，这也取决于个别案件的环境和调查背景。出于这个原因，法医病理学家不断质疑是否有必要进一步调查尸检标本中可疑的人工福尔马林色素沉淀的诊断。

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引用次数: 0

Regarding the “Commotio cordis: Insights from a case of blunt chest trauma and a road map for the correct diagnosis” 关于“心脏震颤：钝性胸外伤1例的启示及正确诊断路线图”

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-10 DOI: 10.1016/j.legalmed.2025.102744

Aleksa Leković , Slobodan Nikolić

引用次数: 0

Establishing models for postmortem interval estimation based on measuring surface temperature of corpses and ambient temperature by infrared thermography technology 利用红外热成像技术，在测量尸体表面温度和环境温度的基础上，建立了尸检间隔估计模型

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-10 DOI: 10.1016/j.legalmed.2025.102745

Chunyan Tu , Hao Zhou , Runting Dou , Yongjing Li , Tan Li , Tingting Yu , Nuo Cheng , Jingjing Niu , Yaling Xie , Heng Zhang

Body temperature is an important indicator for forensic scientists to estimate the early post-mortem interval (PMI). Traditionally, forensic practitioners have mostly used methods such as measuring the internal temperatures of the body, including rectal temperature and liver temperature, to infer the PMI. However, these methods rely on the experience of the operator, suffer from manual measurement errors, and cannot fully consider the interference of environmental factors, resulting in unstable accuracy of the inference results. Infrared thermography technology can use optoelectronic technology to dynamically and monitor the surface temperature of objects and ambient temperature. It has the advantages of non-contact, convenience, and high efficiency. This project utilized thermography technology to monitor the surface temperature of SD rat corpses and the real-time ambient temperature under five average environment temperature conditions of 25 °C, 20 °C, 15 °C, 10 °C, and 5 °C, aiming to explore the correlations among the changes in body surface temperature, ambient temperature changes, and PMI. By comparing the changes in body surface temperature of rabbits, SD rats, and C57 mice, the project investigated the relationship between body weight and the rate of body surface temperature decrease. Then, multivariate correlation analysis, multiple regression analysis, and machine learning analysis methods were employed to construct and evolve models for PMI estimation. Finally, the accuracy of the model was verified using the single-blind method. The results showed that using infrared thermography to detect body surface temperature and ambient temperature can more conveniently and accurately infer the PMI, demonstrating high application and transformation value.

体温是法医判断早期死后时间间隔的重要指标。传统上，法医从业者大多使用测量身体内部温度（包括直肠温度和肝脏温度）等方法来推断PMI。然而，这些方法依赖于操作者的经验，存在人工测量误差，不能充分考虑环境因素的干扰，导致推理结果的准确性不稳定。红外热成像技术可以利用光电技术对物体表面温度和环境温度进行动态监测。它具有非接触、方便、高效等优点。本项目利用热成像技术，在25℃、20℃、15℃、10℃、5℃五种平均环境温度条件下，监测SD大鼠尸体体表温度与实时环境温度，探讨体表温度变化、环境温度变化与PMI之间的相关性。本项目通过比较家兔、SD大鼠和C57小鼠体表温度的变化，探讨体重与体表温度下降速率的关系。然后，采用多元相关分析、多元回归分析和机器学习分析等方法构建并演化PMI估计模型。最后，采用单盲法对模型的精度进行了验证。结果表明，利用红外热像仪检测体表温度和环境温度可以更方便、更准确地推断PMI，具有较高的应用和转化价值。

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引用次数: 0

Myocardial calcification revealed by postmortem computed tomography in a case of infantile myocardial ischemia caused by anomalous origin of the left coronary artery from the pulmonary artery 左冠状动脉起源于肺动脉的异常引起的婴儿心肌缺血的死后计算机断层显示心肌钙化。

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-10 DOI: 10.1016/j.legalmed.2025.102743

Haruki Fukuda , Akira Hayakawa , Yoichiro Takahashi , Hiroyuki Tokue , Rie Sano

Bland-Garland-White syndrome, or an anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA), is a rare congenital coronary anomaly that can cause myocardial ischemia, congestive heart failure, and sudden death. In this study, we aimed to present a case of sudden infant death caused by ALCAPA. Postmortem computed tomography (PMCT) showed a collapsed left lung, enlarged heart volume, and severe calcification of the left ventricular papillary muscles and posterior left ventricular wall. Macroscopic examination during the autopsy revealed marked cardiac hypertrophy and an anomalous left coronary artery originating from the pulmonary artery. Furthermore, microscopic examination showed significant myocardial fibrosis with severe left ventricular calcification. Histological findings revealed features of acute-on-chronic myocardial ischemia, including myocytolysis around fibrotic and calcified areas, contraction-band necrosis, and a characteristic wavy cardiomyocyte pattern. In this case, we suggest that localized myocardial calcification detected by PMCT, particularly following three-dimensional visualization, may be useful for the postmortem assessment of ALCAPA and other causes of chronic myocardial ischemia in infants.

Bland-Garland-White综合征，或称左冠状动脉起源于肺动脉的异常（ALCAPA），是一种罕见的先天性冠状动脉异常，可导致心肌缺血、充血性心力衰竭和猝死。在本研究中，我们的目的是报告一例由ALCAPA引起的婴儿猝死。死后计算机断层扫描（PMCT）显示左肺萎陷，心脏体积增大，左心室乳头肌和左心室后壁严重钙化。尸检时的肉眼检查显示明显的心脏肥大和起源于肺动脉的左冠状动脉异常。镜下检查显示明显的心肌纤维化和严重的左心室钙化。组织学结果显示急性慢性心肌缺血的特征，包括纤维化区和钙化区周围的肌细胞溶解，收缩带坏死和特征性的波浪形心肌细胞模式。在这种情况下，我们建议PMCT检测局部心肌钙化，特别是在三维可视化之后，可能对死后评估ALCAPA和其他导致婴儿慢性心肌缺血的原因有用。

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引用次数: 0

Machine learning analysis facilitates the identification of liver biomarkers in postmortem diagnosis of heat stroke 机器学习分析有助于在中暑死后诊断中识别肝脏生物标志物。

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.legalmed.2025.102739

Meichen Pan , Huine Liu , Chuxiong Ma, Ying Dong, HongMei Dong

Background

Clarifying the cause of death of heat stroke (HS) is critical for judicial handling of related cases. Yet, postmortem diagnosis of HS remains challenging owing to the lack of specific morphology and biomarkers. Liver damage frequently acts as a direct cause in HS. This study aimed to explore the postmortem diagnosis of HS based on the protein biomarkers in liver by machine learning methods.

Methods

Electron microscopy was used to observe the morphological features of hepatocytes in HS. Five candidate protein biomarkers were selected based on the literature, the eletron microscopy observation, and the previously proteomics results. Western blotting and Immunohistochemistry were used to detect candidate proteins expression in both HS rat models and human cases. Lastly, a machine learning algorithm (eXtreme Gradient Boosting, XGBoost) was employed to detect the most discriminative biomarkers.

Results

The mitochondrial damage, autophagy could be observed in hepatocytes of HS. Five candidate protein biomarkers (LRPPRC, CPT2, GPX2, LATS1, and ULK2) were decreased in both HS rat models and HS human cases. The postmortem temporal changes of biomarkers showed that LATS1 and CPT2 were stable. XGBoost revealed LATS1 and CPT2 were the most discriminative biomarkers. The combination of LATS1 and CPT2 achieved optimal diagnostic efficiency, with a sensitivity of 90.91 % and a specificity of 100 %. A diagnostic software was constructed and was applied to five human cases, all of which were recognized.

Conclusion

This study provides a promising valid strategy for practical diagnosis of death from HS by integrating liver LATS1 and CPT2 protein biomarkers.

背景：明确中暑死亡原因对司法处理相关案件至关重要。然而，由于缺乏特定的形态学和生物标志物，死后诊断HS仍然具有挑战性。肝损伤通常是HS的直接病因。本研究旨在通过机器学习方法，探索基于肝脏蛋白质生物标志物的HS死后诊断。方法：采用电镜观察肝细胞形态学特征。根据文献、电镜观察和先前的蛋白质组学结果，选择5个候选蛋白质生物标志物。Western blotting和免疫组织化学检测HS大鼠模型和人病例中候选蛋白的表达。最后，使用机器学习算法（eXtreme Gradient Boosting, XGBoost）来检测最具鉴别性的生物标志物。结果：大鼠肝细胞出现线粒体损伤和自噬现象。5种候选蛋白生物标志物（LRPPRC、CPT2、GPX2、LATS1和ULK2）在HS大鼠模型和HS人病例中均降低。死后生物标志物的时间变化表明，LATS1和CPT2是稳定的。XGBoost显示LATS1和CPT2是最具鉴别性的生物标志物。结合LATS1和CPT2的诊断效果最佳，敏感性为90.91%，特异性为100%。构建了一个诊断软件，并应用于5例人类病例，所有病例都得到了识别。结论：结合肝脏LATS1和CPT2蛋白生物标志物，为HS死亡的实际诊断提供了一种有希望的有效策略。

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引用次数: 0

Sudden death related to tuberculous myocarditis: An autopsy case report 结核性心肌炎所致猝死1例尸检报告

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.legalmed.2025.102741

Mariem Grayaa , Oumeima Bouzid , Asma Ben Mabrouk , Mohamed Amine Zaara , Taher Sakly , Abdelfattah Zakhama , Nidhal Haj Salem

Tuberculous myocarditis is a rare manifestation of disseminated tuberculosis that is often misdiagnosed. It may present with non-specific symptoms, or alternatively remain clinically silent, making diagnosis particularly challenging. We present in this paper a case report of a 49-year-old man with a medical history of diabetes, untreated hypertension, and dyslipidemia was found dead in his home. There was no specific symptom before death. A medico-legal autopsy was requested to determine the cause of death. At the internal examination, there were bilateral yellow-citrine pleural effusion, pulmonary edema with congestion, whitish areas in the left ventricular myocardium. Histopathological analysis showed granulomatous myocarditis associated with interstitial granulomatous pneumonitis suggestive of miliary tuberculosis. The cause of death was attributed to acute heart failure related to undiagnosed tuberculous myocarditis.

结核性心肌炎是弥散性结核的一种罕见表现，常被误诊。它可能表现为非特异性症状，或者在临床上保持沉默，使诊断特别具有挑战性。我们在这篇论文中提出了一个病例报告，49岁的男性糖尿病病史，未经治疗的高血压和血脂异常被发现死在他的家里。死前没有特别的症状要求进行法医解剖以确定死因。内部检查可见双侧黄黄色胸腔积液，肺水肿伴充血，左心室心肌白色区。组织病理学分析显示肉芽肿性心肌炎与间质性肉芽肿性肺炎相关，提示军事性肺结核。死亡原因是未确诊的结核性心肌炎引起的急性心力衰竭。

引用次数: 0

Liposuction associated fatalities in Istanbul from a forensic perspective: An autopsy study 从法医角度看伊斯坦布尔吸脂相关死亡：一项尸检研究。

IF 1.4 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine

Pub Date : 2025-11-01 DOI: 10.1016/j.legalmed.2025.102740

Aytül Buğra , Hüseyin Çağrı Şahin , Beyza Keskin Öztürk , Kadriye Ebru Akar , Halit Çakır , Zekeriya Kul , Hızır Aslıyüksek

Background

Liposuction remains one of the most commonly performed cosmetic surgical procedures worldwide, yet fatal complications continue to occur despite advances in surgical techniques. This study aims to conduct forensic pathological analysis of liposuction-related deaths to identify specific complications, underlying causes, and patterns of fatal outcomes.

Methods

This retrospective study analyzed 35 fatal cases following liposuction procedures autopsied at the Council of Forensic Medicine, Turkey, between January 2022 and December 2024. Autopsy findings, histopathological examinations, demographic characteristics, and toxicological results were systematically evaluated.

Results

All cases were female with a mean age of 41.7 ± 9.5 years and mean BMI of 29.5 ± 3.7 kg/m². Postoperative clinical deterioration occurred in 80.0 % of cases, requiring hospitalization in 62.9 %. Multiple surgical procedures were performed in 85.7 % of cases, with abdominoplasty (94.3 %), mammoplasty (57.1 %), and gluteal fat grafting (54.3 %) being most common. Pulmonary thromboembolism was the most frequent complication (65.7 %), followed by deep vein thrombosis (40.0 %). Histopathologically, pulmonary edema (71.4 %) and pulmonary fat embolism (68.6 %) were predominant findings. BMI was significantly higher in cases with pulmonary thromboembolism (p = 0.004). All five intraoperative deterioration cases involved gluteal fat injection.

Conclusion

Fatal liposuction complications have multifactorial etiology, with high BMI, multiple procedures, and gluteal fat transfer representing major risk factors. Comprehensive preoperative assessment, enhanced safety protocols, and close postoperative monitoring are essential for mortality reduction.

背景：吸脂术仍然是世界范围内最常见的美容外科手术之一，尽管手术技术不断进步，但致命的并发症仍在发生。本研究旨在对吸脂相关死亡进行法医病理学分析，以确定特定并发症、潜在原因和致命结局模式。方法：本回顾性研究分析了2022年1月至2024年12月期间在土耳其法医学委员会尸检的35例吸脂术后死亡病例。对尸检结果、组织病理学检查、人口学特征和毒理学结果进行系统评估。结果：所有病例均为女性，平均年龄41.7±9.5岁，平均BMI为29.5±3.7 kg/m2。80.0%的病例发生术后临床恶化，62.9%需要住院治疗。85.7%的病例进行了多次手术，其中腹部成形术（94.3%）、乳房成形术（57.1%）和臀脂肪移植术（54.3%）最为常见。肺血栓栓塞是最常见的并发症（65.7%），其次是深静脉血栓形成（40.0%）。组织病理学上以肺水肿（71.4%）和肺脂肪栓塞（68.6%）为主要表现。肺血栓栓塞患者的BMI显著增高（p = 0.004）。5例术中恶化病例均涉及臀脂肪注射。结论：致死性吸脂并发症具有多因素病因，高BMI、多手术、臀脂肪转移是主要危险因素。全面的术前评估、加强的安全方案和密切的术后监测对降低死亡率至关重要。

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引用次数: 0