Pub Date : 2025-12-08DOI: 10.1016/s1473-3099(25)00680-2
Ernesto T A Marques, Simon Barratt-Boyes
No Abstract
没有抽象的
{"title":"Chikungunya adolescent vaccination and the distinct risk–benefit landscapes","authors":"Ernesto T A Marques, Simon Barratt-Boyes","doi":"10.1016/s1473-3099(25)00680-2","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00680-2","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"11 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1016/s1473-3099(25)00662-0
Direk Limmathurotsakul, Raheelah Ahmad, Elizabeth A Ashley, Rifat Atun, Rogier H van Doorn, Jyoti Joshi, Souha S Kanj, Janet Midega, Mirfin Mpundu, Paul Turner, Kamini Walia, Sharon J Peacock, Nicholas A Feasey
Antimicrobial resistance (AMR) is a growing global health threat, and many public health surveillance programmes rely on blood cultures as a means to track this process. Blood cultures are diagnostic tests taken from patients with suspected sepsis or bloodstream infections, where timely results can be lifesaving. When blood culture-based AMR surveillance is instituted for global AMR monitoring, these investments might not realise their full potential in supporting patient care if their role as a diagnostic is not optimised, creating the risk that local hospitals see little benefit from surveillance activities and making such programmes less sustainable. We argue that blood cultures should be viewed first and foremost as a key diagnostic tool to guide patient care. By ensuring that local hospitals can use and act on their own data, we can both improve outcomes for patients and strengthen global AMR surveillance efforts.
{"title":"Transitioning to people-centred antimicrobial resistance surveillance","authors":"Direk Limmathurotsakul, Raheelah Ahmad, Elizabeth A Ashley, Rifat Atun, Rogier H van Doorn, Jyoti Joshi, Souha S Kanj, Janet Midega, Mirfin Mpundu, Paul Turner, Kamini Walia, Sharon J Peacock, Nicholas A Feasey","doi":"10.1016/s1473-3099(25)00662-0","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00662-0","url":null,"abstract":"Antimicrobial resistance (AMR) is a growing global health threat, and many public health surveillance programmes rely on blood cultures as a means to track this process. Blood cultures are diagnostic tests taken from patients with suspected sepsis or bloodstream infections, where timely results can be lifesaving. When blood culture-based AMR surveillance is instituted for global AMR monitoring, these investments might not realise their full potential in supporting patient care if their role as a diagnostic is not optimised, creating the risk that local hospitals see little benefit from surveillance activities and making such programmes less sustainable. We argue that blood cultures should be viewed first and foremost as a key diagnostic tool to guide patient care. By ensuring that local hospitals can use and act on their own data, we can both improve outcomes for patients and strengthen global AMR surveillance efforts.","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"211 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145704237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/s1473-3099(25)00745-5
Behrens GMN, Assoumou L, Liegeon G, et al. Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial. Lancet Infect Dis 2025; published online Dec 1. https://doi.org/10.1016/S1473-3099(25)00681-4—In this Article, the spelling of author Montserrat Laguno's name was incorrect. This correction has been made to the online version as of Dec 2, 2025, and will be made to the printed version.
{"title":"Correction to Lancet Infect Dis 2025; published online Dec 1. https://doi.org/10.1016/S1473-3099(25)00681-4","authors":"","doi":"10.1016/s1473-3099(25)00745-5","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00745-5","url":null,"abstract":"<em>Behrens GMN, Assoumou L, Liegeon G, et al. Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial.</em> Lancet Infect Dis <em>2025; published online Dec 1. https://doi.org/10.1016/S1473-3099(25)00681-4</em>—In this Article, the spelling of author Montserrat Laguno's name was incorrect. This correction has been made to the online version as of Dec 2, 2025, and will be made to the printed version.","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"128 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145664531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/s1473-3099(25)00630-9
Yumi Sheehan, Akhil Garg, Julia Sheehan, Nonso Maduka, Frederick L Altice, Filipa Alves da Costa, Sean Cox, Ahmed M Elsharkawy, Ehab Salah, Mark Stoové, Lara Tavoschi, Alexander J Thompson, Karla Thornton, Andrew R Lloyd, Joaquín Cabezas, Matthew J Akiyama, Nadine Kronfli
{"title":"Best practice guidelines for viral hepatitis service delivery in prisons","authors":"Yumi Sheehan, Akhil Garg, Julia Sheehan, Nonso Maduka, Frederick L Altice, Filipa Alves da Costa, Sean Cox, Ahmed M Elsharkawy, Ehab Salah, Mark Stoové, Lara Tavoschi, Alexander J Thompson, Karla Thornton, Andrew R Lloyd, Joaquín Cabezas, Matthew J Akiyama, Nadine Kronfli","doi":"10.1016/s1473-3099(25)00630-9","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00630-9","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"198200 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/s1473-3099(25)00681-4
Georg M N Behrens, Lambert Assoumou, Geoffroy Liegeon, Andrea Antinori, Rafael Micán, Francesco G Genderini, Frank A Post, Jürgen K Rockstroh, Lisa Hamzah, Pere Domingo, Adrian Curran, Monserrat Laguno, Carl Fletcher, Jack Moody, Anton Pozniak
<h3>Background</h3>To date, clinical trials have been underpowered to assess which antiretrovirals perform best in people with advanced HIV disease. We aimed to investigate the efficacy and safety of an integrase inhibitor-containing versus a boosted protease inhibitor-containing regimen for this population.<h3>Methods</h3>In this open-label, multicentre, non-inferiority trial in seven European countries (Spain, France, Italy, Germany, Belgium, Ireland, and the UK), therapy-naive adults with advanced HIV disease were randomly allocated (1:1) to receive either bictegravir, emtricitabine, and tenofovir alafenamide (integrase inhibitor group) or darunavir, cobicistat, emtricitabine, and tenofovir alafenamide (boosted protease inhibitor group) for 48 weeks. Randomisation was computer generated in permuted blocks within strata with block sizes of four and stratified by country and baseline CD4 cell count. The primary composite outcome (time to first occurrence of specified virological or clinical events) and its components were evaluated by Kaplan–Meier and Cox regression analyses in both modified intention-to-treat (mITT) and per-protocol populations. The mITT population included all randomly allocated participants who received at least one dose of the study drug, whereas the per-protocol population excluded those who received incorrect treatment. Non-inferiority of the integrase inhibitor-based regimen versus the boosted protease inhibitor-containing regimen was declared if the upper limit of the 95% CI of the hazard ratio (HR) for the primary composite endpoint was less than 1·606, corresponding to a 12% difference in the cumulative probability of the composite primary endpoint. Adverse events, a secondary endpoint, were recorded at eight visits in all participants. This trial is registered with <span><span>ClinicalTrials.gov</span><svg aria-label="Opens in new window" focusable="false" height="20" viewbox="0 0 8 8"><path d="M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z"></path></svg></span>, <span><span>NCT03696160</span><svg aria-label="Opens in new window" focusable="false" height="20" viewbox="0 0 8 8"><path d="M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z"></path></svg></span>, and is completed.<h3>Findings</h3>Between May 13, 2019, and June 26, 2023, 222 people were randomly assigned to the integrase inhibitor group and 225 to the boosted protease inhibitor group. Of these 447 recruited participants, 442 (99%) participants with a median CD4 count of 41 cells per μL (IQR 17–79) received at least one dose. 358 (81%) of the 442 treated participants self-reported as male and 84 (19%) female, and 276 (62%) were of White ethnicity, 83 (19%) Black, and 83 (19%) other. In the mITT analysis, the 48-week composite primary outcome event occurred in 49 (22%) of 220 participants in the integrase inhibitor group versus 70 (32%) of 222 participants in the boosted protease
{"title":"Integrase versus protease inhibitor therapy in advanced HIV disease (LAPTOP): a multicountry, randomised, open-label, non-inferiority trial","authors":"Georg M N Behrens, Lambert Assoumou, Geoffroy Liegeon, Andrea Antinori, Rafael Micán, Francesco G Genderini, Frank A Post, Jürgen K Rockstroh, Lisa Hamzah, Pere Domingo, Adrian Curran, Monserrat Laguno, Carl Fletcher, Jack Moody, Anton Pozniak","doi":"10.1016/s1473-3099(25)00681-4","DOIUrl":"https://doi.org/10.1016/s1473-3099(25)00681-4","url":null,"abstract":"<h3>Background</h3>To date, clinical trials have been underpowered to assess which antiretrovirals perform best in people with advanced HIV disease. We aimed to investigate the efficacy and safety of an integrase inhibitor-containing versus a boosted protease inhibitor-containing regimen for this population.<h3>Methods</h3>In this open-label, multicentre, non-inferiority trial in seven European countries (Spain, France, Italy, Germany, Belgium, Ireland, and the UK), therapy-naive adults with advanced HIV disease were randomly allocated (1:1) to receive either bictegravir, emtricitabine, and tenofovir alafenamide (integrase inhibitor group) or darunavir, cobicistat, emtricitabine, and tenofovir alafenamide (boosted protease inhibitor group) for 48 weeks. Randomisation was computer generated in permuted blocks within strata with block sizes of four and stratified by country and baseline CD4 cell count. The primary composite outcome (time to first occurrence of specified virological or clinical events) and its components were evaluated by Kaplan–Meier and Cox regression analyses in both modified intention-to-treat (mITT) and per-protocol populations. The mITT population included all randomly allocated participants who received at least one dose of the study drug, whereas the per-protocol population excluded those who received incorrect treatment. Non-inferiority of the integrase inhibitor-based regimen versus the boosted protease inhibitor-containing regimen was declared if the upper limit of the 95% CI of the hazard ratio (HR) for the primary composite endpoint was less than 1·606, corresponding to a 12% difference in the cumulative probability of the composite primary endpoint. Adverse events, a secondary endpoint, were recorded at eight visits in all participants. This trial is registered with <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, <span><span>NCT03696160</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>, and is completed.<h3>Findings</h3>Between May 13, 2019, and June 26, 2023, 222 people were randomly assigned to the integrase inhibitor group and 225 to the boosted protease inhibitor group. Of these 447 recruited participants, 442 (99%) participants with a median CD4 count of 41 cells per μL (IQR 17–79) received at least one dose. 358 (81%) of the 442 treated participants self-reported as male and 84 (19%) female, and 276 (62%) were of White ethnicity, 83 (19%) Black, and 83 (19%) other. In the mITT analysis, the 48-week composite primary outcome event occurred in 49 (22%) of 220 participants in the integrase inhibitor group versus 70 (32%) of 222 participants in the boosted protease ","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"7 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-21DOI: 10.1016/S1473-3099(25)00632-2
David N Durrheim, Ilisapeci Vereti Tuibeqa, Saia Ma'u Piukala
{"title":"Elimination of measles and rubella in Pacific island countries and areas.","authors":"David N Durrheim, Ilisapeci Vereti Tuibeqa, Saia Ma'u Piukala","doi":"10.1016/S1473-3099(25)00632-2","DOIUrl":"10.1016/S1473-3099(25)00632-2","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":" ","pages":"1272-1273"},"PeriodicalIF":31.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-22DOI: 10.1016/S1473-3099(25)00661-9
{"title":"Correction to Lancet Infect Dis 2025; published online Oct 10. https://doi.org/10.1016/S1473-3099(25)00549-3.","authors":"","doi":"10.1016/S1473-3099(25)00661-9","DOIUrl":"10.1016/S1473-3099(25)00661-9","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":" ","pages":"e684"},"PeriodicalIF":31.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-21DOI: 10.1016/S1473-3099(25)00625-5
Philip J Budge, Catherine M Bjerum, Allassane Foungoye Ouattara, Peter U Fischer, Guibehi Benjamin Koudou
{"title":"Moxidectin combination therapies for lymphatic filariasis-36-month follow-up.","authors":"Philip J Budge, Catherine M Bjerum, Allassane Foungoye Ouattara, Peter U Fischer, Guibehi Benjamin Koudou","doi":"10.1016/S1473-3099(25)00625-5","DOIUrl":"10.1016/S1473-3099(25)00625-5","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":" ","pages":"e683"},"PeriodicalIF":31.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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