Pub Date : 2026-02-05DOI: 10.1016/s1473-3099(26)00054-x
Seth D Judson, Claude Kwe Yinda, Franziska K Kaiser, Daniel S Chertow, Emmie de Wit, James O Lloyd-Smith, Vincent J Munster
{"title":"Circulation of clade Ib mpox outside of Africa—are we prepared?","authors":"Seth D Judson, Claude Kwe Yinda, Franziska K Kaiser, Daniel S Chertow, Emmie de Wit, James O Lloyd-Smith, Vincent J Munster","doi":"10.1016/s1473-3099(26)00054-x","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00054-x","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"126 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1016/s1473-3099(26)00004-6
Thomas S Harrison, Thomas J Walsh
Mortality from invasive aspergillosis remains unacceptably high, and the currently recommended treatment of triazoles is further challenged by rising resistance to these first-line agents. A previous randomised controlled trial of combination therapy with voriconazole plus anidulafungin versus voriconazole alone showed that the combination was safe and associated with a clinically significant reduction in all-cause mortality that, however, failed narrowly to meet conventional levels of significance. In this Personal View, we argue against a binary, negative interpretation of these results, and that the totality of the laboratory and clinical evidence favours a triazole–echinocandin combination for the treatment of immunocompromised patients with proven or probable invasive aspergillosis. Renewed efforts are needed to optimise and evaluate other combination approaches for aspergillosis and other life-threatening invasive fungal diseases as a means by which to mitigate antifungal resistance, maximise and prolong the utility of old and new agents, and drive down mortality.
{"title":"Time to re-evaluate combination antifungal therapy for invasive aspergillosis and other invasive mycoses","authors":"Thomas S Harrison, Thomas J Walsh","doi":"10.1016/s1473-3099(26)00004-6","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00004-6","url":null,"abstract":"Mortality from invasive aspergillosis remains unacceptably high, and the currently recommended treatment of triazoles is further challenged by rising resistance to these first-line agents. A previous randomised controlled trial of combination therapy with voriconazole plus anidulafungin versus voriconazole alone showed that the combination was safe and associated with a clinically significant reduction in all-cause mortality that, however, failed narrowly to meet conventional levels of significance. In this Personal View, we argue against a binary, negative interpretation of these results, and that the totality of the laboratory and clinical evidence favours a triazole–echinocandin combination for the treatment of immunocompromised patients with proven or probable invasive aspergillosis. Renewed efforts are needed to optimise and evaluate other combination approaches for aspergillosis and other life-threatening invasive fungal diseases as a means by which to mitigate antifungal resistance, maximise and prolong the utility of old and new agents, and drive down mortality.","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"9 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1016/s1473-3099(26)00066-6
De Coster I, AbdelGhany M, Sarakinou E, et al. Safety and immunogenicity of a conjugate vaccine candidate against Salmonella enterica serovars Typhi and Paratyphi A in healthy adults in Europe: a phase 1 randomised controlled trial. Lancet Infect Dis 2026; published online Jan 23. https://doi.org/10.1016/S1473-3099(25)00730-3—In the Acknowledgments of this Article, the funding statement should have been “This work was funded by the Wellcome Trust [089102/Z/09/Z] and this publication was sponsored by GSK.” This correction has been made to the online version as of Feb 4, 2026, and will be made to the printed version.
De Coster I, AbdelGhany M, Sarakinou E，等。欧洲健康成人抗伤寒和甲型副伤寒沙门氏菌血清型结合疫苗的安全性和免疫原性：一项1期随机对照试验柳叶刀感染杂志；2026；1月23日在线发布。https://doi.org/10.1016/S1473-3099(25)00730-3 -在本文的致谢中，资金声明应该是“这项工作由Wellcome Trust [089102/Z/09/Z]资助，本出版物由GSK赞助。”此更正已于2026年2月4日对在线版本进行，并将对印刷版本进行更正。
{"title":"Correction to Lancet Infect Dis 2026; published online Jan 23. https://doi.org/10.1016/S1473-3099(25)00730-3","authors":"","doi":"10.1016/s1473-3099(26)00066-6","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00066-6","url":null,"abstract":"<em>De Coster I, AbdelGhany M, Sarakinou E, et al. Safety and immunogenicity of a conjugate vaccine candidate against</em> Salmonella enterica <em>serovars Typhi and Paratyphi A in healthy adults in Europe: a phase 1 randomised controlled trial.</em> Lancet Infect Dis <em>2026; published online Jan 23. https://doi.org/10.1016/S1473-3099(25)00730-3</em>—In the Acknowledgments of this Article, the funding statement should have been “This work was funded by the Wellcome Trust [089102/Z/09/Z] and this publication was sponsored by GSK.” This correction has been made to the online version as of Feb 4, 2026, and will be made to the printed version.","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"162 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1016/s1473-3099(26)00067-8
Vijay Shankar Balakrishnan
{"title":"Leishmaniasis: a story of two continents","authors":"Vijay Shankar Balakrishnan","doi":"10.1016/s1473-3099(26)00067-8","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00067-8","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"30 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1016/s1473-3099(26)00068-x
Carrie Fielden
No Abstract
没有抽象的
{"title":"Finding your voice in a world of uncertainty","authors":"Carrie Fielden","doi":"10.1016/s1473-3099(26)00068-x","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00068-x","url":null,"abstract":"No Abstract","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"301 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/s1473-3099(26)00064-2
Tony Kirby
{"title":"Reem Abu Shomar— championing water safety in Gaza","authors":"Tony Kirby","doi":"10.1016/s1473-3099(26)00064-2","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00064-2","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"29 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-28DOI: 10.1016/s1473-3099(26)00025-3
Mojdeh Azimi, Dick Menzies
{"title":"Strength of ATLAS or lady luck in a sepsis management trial?","authors":"Mojdeh Azimi, Dick Menzies","doi":"10.1016/s1473-3099(26)00025-3","DOIUrl":"https://doi.org/10.1016/s1473-3099(26)00025-3","url":null,"abstract":"","PeriodicalId":49923,"journal":{"name":"Lancet Infectious Diseases","volume":"31 1","pages":""},"PeriodicalIF":56.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146071543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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