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Morphologic alterations in the mucosa of the denture site in patients with full removable dentures from acrylic plastics 丙烯酸塑料全活动义齿患者义齿部位黏膜的形态学改变
Pub Date : 2023-11-06 DOI: 10.33667/2078-5631-2023-20-12-17
A. S. Peremyshlenko, A. K. Iordanishvili, N. N. Bedelov, K. A. Kerimkhanov
Relevance . Currently, many new agents have appeared on the market for users of removable dentures to improve adhesion, i.e. fixation and stabilization of dentures. It is important to evaluate the effect of such agents on the denture bed mucosa. Objective. Morphological substantiation of the effectiveness of the use of adhesive cream for fixation of prostheses Asepta Рarodontalu patients with removable dentures made of acrylic plastic. Materials and methods . The study involved 49 patients (12 men and 37 women) of elderly age (62–75 years) who suffered complete loss of teeth on both jaws. All patients were divided into 3 study groups: 1 (control) group, who had previously refused to have full removable acrylic dentures made for them; 2 (comparison) group, patients to whom removable acrylic dentures were made and who did not use any means to improvetheir fixation; 3 (main) group, patients to whom full removable acrylic dentures were made and who during the adaptation period and subsequently for a year used a domestic adhesive cream for fixation; 3 (main) group, patients to whom full removable acrylic dentures were made. In order to solve the realization of the set goal of the study, a number of clinical and histological studies with the use of immunohistochemical method were carried out, outpatient charts of dental patients were analyzed. Results . It was found that dystrophic and chronic inflammatory changes in the soft tissues of the denture bed were most pronounced in the case of using dentures without means to improve their fixation. At use of domestic adhesive cream for fixation of dentures Asepta Рarodontal the process of keratinization of the oral mucous membrane epithelium was minimal, there was no fibrosis of the own lamina of the mucous membrane, scattered infiltration was less expressed than in people not using acrylic dentures or using them without adhesive means, and was represented at the expense of lymphocytes, single neutrophilic granulocytes on the background of single leukostases. The immunohistochemical study showed that T-lymphocytes and mast cells were predominant in the preparations of group 2 patients, and they appeared in the preparations of this group of patients comparatively more than in the 1st control and 3rd main groups of the study, which confirmed the presence of the most pronounced chronic inflammatory infiltration in group 2 patients. Conclusion . The most optimal condition of the denture bed mucosa was observed in patients who used removable acrylic dentures for a year and simultaneously applied an adhesive agent for their fixation (domestic adhesive cream for denture fixation Asepta Рarodontal). It is obviously connected with the protection of the mucous membrane of the prosthetic bed by the adhesive cream from the mechanical impact of a dense acrylic plastic prosthesis, as well as with the reduction of contact with food products aggressive in temperature and structure.
的相关性。目前,市场上出现了许多新的制剂,用于改善义齿使用者的粘连,即固定和稳定义齿。评价这些药物对义齿床粘膜的影响是非常重要的。目标。形态学证实使用黏附膏固定假体Asepta Рarodontalu丙烯酸塑料可摘义齿患者的有效性。材料和方法。该研究涉及49名老年(62-75岁)患者(12名男性和37名女性),他们的双颌牙齿全部脱落。所有患者分为3个研究组:1(对照组)组,先前拒绝为其制作全活动丙烯酸酯义齿;2(比较)组:制作活动丙烯义齿,不采用任何方法改善固定;3(主)组:制作全口可摘丙烯酸义齿,适应期及随后1年使用国产黏合剂固定的患者;3(主)组:制作全口可摘丙烯酸酯义齿的患者。为了解决既定研究目标的实现,采用免疫组织化学方法进行了多项临床和组织学研究,分析了牙科患者门诊病历。结果。我们发现,在使用义齿而不改善固定的情况下,义齿床软组织的营养不良和慢性炎症变化最为明显。使用国产黏附乳膏固定义齿时,口腔黏膜上皮的角化过程最小,自身粘膜层无纤维化,散在性浸润的表达少于不使用丙烯酸义齿或不使用黏附手段的人,以淋巴细胞为代价,以单一的嗜中性粒细胞为背景,单一的白细胞增多。免疫组化研究显示,在2组患者的制剂中,t淋巴细胞和肥大细胞占主导地位,并且在该组患者的制剂中出现的t淋巴细胞和肥大细胞的数量相对多于本研究的第一对照组和第三主要组,这证实了2组患者存在最明显的慢性炎症浸润。结论。使用可摘丙烯酸义齿1年,同时使用黏合剂固定义齿(国产义齿固定黏合剂Asepta Рarodontal)的患者,观察义齿床黏膜的最佳状态。这显然与胶膏保护假体床的粘膜免受致密丙烯酸塑料假体的机械冲击有关,也与减少与温度和结构上具有侵略性的食品的接触有关。
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引用次数: 0
Probiotics – a new panacea for periodontal diseases?! Literature review 益生菌——治疗牙周病的新灵丹妙药?!文献综述
Pub Date : 2023-11-06 DOI: 10.33667/2078-5631-2023-20-30-34
D. T. Taimazova, M. Z. Choniashvili, V. M. Avanisyan, U. B. Edisherashvili, E. M. Jafarov
Introduction. The emergence of new antibiotic-resistant strains of microorganisms, the widespread spread of viral and fungal diseases, as well as the growing allergisation of the population have generated interest in bacterial preparations – probiotics, which include living microorganisms – representatives, as a rule, of the obligate human microflora, which, when ingested in sufficient quantities, enter the body, retain their activity and viability, have a positive effect on the patient’s health. The purpose of the study was to review the literature on this topic, to determine the concepts of the use of probiotics in dentistry, as well as to identify promising directions in the development of methods of therapy of periodontal diseases with their use. Materials and methods. When studying this issue, scientific sources indexed in the Higher Attestation Commission, Scopus and Web of Sciences were analyzed. Results. Probiotics are a recognized therapeutic adjunct for various generalized and systemic diseases of the oral cavity. Their role in the prevention and treatment of dental caries, as well as its complications, is a direction that has been studied quite fully in the last two decades. The evidence for this is reflected in many randomized control studies. To test various probiotic combinations, it is necessary to conduct multicenter studies so that patients can take advantage of the entire therapeutic spectrum of new drugs based on probiotics and synbiotics.
介绍。新的耐抗生素的微生物菌株的出现,病毒和真菌疾病的广泛传播,以及人口日益增长的过敏症,引起了人们对细菌制剂的兴趣——益生菌,其中包括活的微生物——通常是专门的人类微生物群的代表,当摄入足够数量时,进入人体,保持其活性和活力,对病人的健康有积极的影响。本研究的目的是回顾有关该主题的文献,确定益生菌在牙科中的应用概念,并确定利用益生菌治疗牙周病方法的发展方向。材料和方法。在研究这一问题时,我们分析了高等认证委员会、Scopus和Web of Sciences收录的科学资源。结果。益生菌是公认的治疗辅助各种广泛性和全身性口腔疾病。它们在预防和治疗龋齿及其并发症方面的作用,是近二十年来研究得相当充分的一个方向。这方面的证据反映在许多随机对照研究中。为了测试各种益生菌组合,有必要进行多中心研究,使患者能够利用基于益生菌和合成菌的新药的整个治疗谱。
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引用次数: 0
Potential Use of Melatonin in Periodontal Disease 褪黑素在牙周病中的潜在应用
Pub Date : 2023-11-06 DOI: 10.33667/2078-5631-2023-20-19-29
S. V. Orlova, S. K. Zyryanov, E. A. Nikitina, Yu. O. Tigay, A. A. Orlova, G. A. Grabovsky
Melatonin is an indoleamine that is secreted not only in the pineal gland, but also in other organs, in particular the salivary glands. Numerous studies show that melatonin levels in the saliva and serum of patients suffering from periodontal disease are reduced, suggesting that it may play an important role in protecting tissues from damage caused by oxidative stress. Melatonin helps regulate the immune response and prevents periodontal tissue damage. The inclusion of melatonin in the periodontal disease treatment regimen increases its effectiveness. Further research is needed to determine the optimal forms and dosing regimens for melatonin.
褪黑素是一种吲哚胺,不仅在松果体中分泌,也在其他器官中分泌,尤其是唾液腺。大量研究表明,牙周病患者唾液和血清中的褪黑素水平降低,表明它可能在保护组织免受氧化应激损伤方面发挥重要作用。褪黑素有助于调节免疫反应,防止牙周组织损伤。在牙周病治疗方案中加入褪黑素可提高其有效性。需要进一步的研究来确定褪黑素的最佳形式和给药方案。
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引用次数: 0
Remineralizing gel with calcium lactate for the prevention of caries in children 乳酸钙再矿化凝胶预防儿童龋齿
Pub Date : 2023-11-06 DOI: 10.33667/2078-5631-2023-20-7-10
E. V. Brusnitsyna, E. S. Ioschenko, I. V. Gavrilov, T. V. Zakirov, L. A. Kaminskaya, N. V. Ozhgikhina, E. S. Bimbas
The article presents the results of a single-center open clinical trial of the use of the remineralizing gel «PRESIDENT Minerals gel 0+». The effectiveness of the drug in children in the period of mixed dentition with a compensated form of caries was studied. Materials and methods . The study involved 19 children, mean age 8,3 years. The duration of the study is 1 month.Clinical indices and laboratory parameters were determined: DMF+df, OHI-S, PMA, the degree of enamel electrometry, calcium, glucose, total protein and antioxidant activity of saliva (AOA). Organoleptic properties were determined on a 5-point scale. Results . After one month of using the remineralizing gel, a decrease in the hygiene index by 23,27%, a decrease in the electrometric evaluation of enamel by 15,58% were revealed. In saliva, a decrease in the level of protein by 33,13% and an increase in the content of calcium by 53,33% were revealed. The organoleptic properties of the gel were evaluated on a five-point scale at 4,31±0,22 points. Conclusion . «PRESIDENT 0+ Minerals gel» with calcium lactate and hydroxyapatite has a remineralizing effect, good organoleptic properties and can be recommended for caries prevention in children.
文章介绍了使用再矿化凝胶«总统矿物凝胶0+»的单中心开放临床试验的结果。研究了该药在儿童混合牙列补偿性龋齿期的疗效。材料和方法。这项研究涉及19名儿童,平均年龄为8.3岁。研究时间为1个月。测定临床指标及实验室参数:DMF+df、OHI-S、PMA、牙釉质电测度、钙、葡萄糖、总蛋白、唾液抗氧化活性(AOA)。感官特性以5分制确定。结果。使用再矿化凝胶1个月后,牙釉质的卫生指数下降了23.27%,电测评价下降了15.58%。在唾液中,蛋白质水平下降了33.13%,钙含量增加了53.33%。以4.31±0.22分的五分制评价凝胶的感官特性。结论。含有乳酸钙和羟基磷灰石的“总统0+矿物质凝胶”具有再矿化作用,良好的感官特性,可推荐用于儿童龋齿预防。
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引用次数: 0
Impact of insomnia and its correction on quality of life of persons with disabilities 失眠症及其矫正对残疾人生活质量的影响
Pub Date : 2023-11-06 DOI: 10.33667/2078-5631-2023-21-14-22
A. N. Akavov, E. A. Korabel'nikova, M. L. Baranov
Aim . To study the effect of insomnia on the severity of the condition and on the quality of life in patients with disabilities. Materials and methods . A prospective cohort study was conducted from 2019 to 2022, in which 100 patients took part. Patients with acute cerebrovascular accident (ACV) were selected as a clinical model of persons with disabilities. Two groups were formed from the total number of patients included in the study. 50 patients with acute cerebrovascular accident and suffering from insomnia constituted the main group, which was divided into 2 subgroups by a simple choice according to the random sampling rule in the Statistica 12 program. MG1 – the main subgroup 1–26 people who received, as part of complex therapy, a course of short-term (five sessions) cognitive-behavioral therapy for insomnia in combination with doxylamine at a dose of 15 mg 15–30 minutes before bedtime for 10 days. The second subgroup of the main group of patients (MG2) – 24 people who received only standard treatment. The comparison group (GS) (50 people) and a part (48 %) of the patients of the main group (24 people) also received only standard treatment for the underlying disease. All patients were assessed using the SF-36 Quality of Life Questionnaire, the Perrudet-Badoux, Mendelsohn, Chiche Subjective Wellbeing Scale (PSS), sleep quality questionnaires (Pittsburgh Sleep Quality Questionnaire and the Insomnia Severity Scale). Results and conclusions . Against the background of the treatment in the main group 1, there was a reduction in insomnia, as well as an improvement in the quality of life on all scales of the quality of life questionnaire and more pronounced than in the comparison group and the main group 2. Thus, the correction of insomnia in addition to the basic therapy of post-stroke patients with limited opportunities allows you to achieve a more significant result of treatment than the use of only basic therapy for patients.
的目标。探讨失眠症对残疾患者病情严重程度及生活质量的影响。材料和方法。一项前瞻性队列研究于2019年至2022年进行,共有100名患者参与。选择急性脑血管意外(ACV)患者作为残疾人的临床模型。根据纳入研究的患者总数分为两组。50例急性脑血管意外并伴有失眠症的患者为主要组,根据Statistica 12程序中的随机抽样规则,通过简单选择将其分为2个亚组。MG1 -主要亚组1-26人,作为复杂治疗的一部分,接受短期(5个疗程)的失眠认知行为治疗,并在睡前15 - 30分钟服用剂量为15毫克的多西胺,持续10天。主要患者组的第二个亚组(MG2) -仅接受标准治疗的24人。对照组(GS)(50人)和主要组(24人)的一部分(48%)患者也只接受基础疾病的标准治疗。采用SF-36生活质量问卷、Perrudet-Badoux, Mendelsohn, Chiche主观幸福感量表(PSS)、睡眠质量问卷(匹兹堡睡眠质量问卷和失眠严重程度量表)对所有患者进行评估。结果和结论。在主要治疗组1的治疗背景下,失眠的情况有所减少,生活质量在生活质量问卷的所有量表上都有所改善,比对照组和主要治疗组2更明显。因此,对机会有限的脑卒中后患者在基础治疗之外进行失眠矫正,可以使患者获得比仅使用基础治疗更显著的治疗效果。
{"title":"Impact of insomnia and its correction on quality of life of persons with disabilities","authors":"A. N. Akavov, E. A. Korabel'nikova, M. L. Baranov","doi":"10.33667/2078-5631-2023-21-14-22","DOIUrl":"https://doi.org/10.33667/2078-5631-2023-21-14-22","url":null,"abstract":"Aim . To study the effect of insomnia on the severity of the condition and on the quality of life in patients with disabilities. Materials and methods . A prospective cohort study was conducted from 2019 to 2022, in which 100 patients took part. Patients with acute cerebrovascular accident (ACV) were selected as a clinical model of persons with disabilities. Two groups were formed from the total number of patients included in the study. 50 patients with acute cerebrovascular accident and suffering from insomnia constituted the main group, which was divided into 2 subgroups by a simple choice according to the random sampling rule in the Statistica 12 program. MG1 – the main subgroup 1–26 people who received, as part of complex therapy, a course of short-term (five sessions) cognitive-behavioral therapy for insomnia in combination with doxylamine at a dose of 15 mg 15–30 minutes before bedtime for 10 days. The second subgroup of the main group of patients (MG2) – 24 people who received only standard treatment. The comparison group (GS) (50 people) and a part (48 %) of the patients of the main group (24 people) also received only standard treatment for the underlying disease. All patients were assessed using the SF-36 Quality of Life Questionnaire, the Perrudet-Badoux, Mendelsohn, Chiche Subjective Wellbeing Scale (PSS), sleep quality questionnaires (Pittsburgh Sleep Quality Questionnaire and the Insomnia Severity Scale). Results and conclusions . Against the background of the treatment in the main group 1, there was a reduction in insomnia, as well as an improvement in the quality of life on all scales of the quality of life questionnaire and more pronounced than in the comparison group and the main group 2. Thus, the correction of insomnia in addition to the basic therapy of post-stroke patients with limited opportunities allows you to achieve a more significant result of treatment than the use of only basic therapy for patients.","PeriodicalId":499576,"journal":{"name":"Medicinskij alfavit","volume":"42 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135681284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and treatment of dizziness and vertigo in clinical practice 眩晕症在临床中的诊断与治疗
Pub Date : 2023-11-06 DOI: 10.33667/2078-5631-2023-21-23-29
S. A. Makarov, A. L. Guseva
The article describes vertigo diagnostic algorithm. Acute, paroxysmal, and chronic vestibular syndromes determination, attacks duration assessment, provoking factors and comorbid diseases are described. The otoneurologic examination main tests and their interpretation in assessing of spontaneous nystagmus, the results of stato-coordination tests, the head rotation test and positional tests are presented. Diagnostic criteria and basic approach to the most common disorders manifested by vertigo treatment are discussed, including benign paroxysmal positional vertigo, vestibular neuronitis, Meniere's disease, vestibular migraine, persistent postural-perceptual vertigo, bilateral vestibulopathy and others.
本文介绍了眩晕诊断算法。急性,阵发性和慢性前庭综合征的测定,攻击持续时间评估,诱发因素和合并症的疾病描述。介绍了评价自发性眼球震颤时耳神经系统检查的主要检查项目、状态协调测试、头部旋转测试和体位测试的结果及其解释。讨论了最常见的眩晕治疗疾病的诊断标准和基本方法,包括良性阵发性位置性眩晕、前庭神经炎、梅尼埃病、前庭偏头痛、持续性体位知觉性眩晕、双侧前庭病变等。
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引用次数: 0
New aspects of the pathogenesis of placental insufficiency 胎盘功能不全发病机制的新进展
Pub Date : 2023-11-05 DOI: 10.33667/2078-5631-2023-19-44-48
S. A. Gasparyan, I. A. Orfanova, S. M. Akhmedova, I. A. Vasilenko
Relevance . Placental insufficiency is a polycausal syndrome characterized by a violation of the molecular, cellular, tissue and organ adaptivehomeostatic reactions of the fetoplacental system. The active participation of the neutrophil component of the innate immune system in the development of endothelial dysfunction and thrombotic disorders, which underlie many complications of pregnancy, has been proven, which served as the reason for conducting exploratory studies to assess the level of neutrophil extracellular traps (NETs) in pregnant women at different stages of gestation. The purpose of the study is to identify the features of the formation of neutrophil extracellular traps in pregnant women with normal pregnancy and placental insufficiency associated with thrombophilia Material and methods . 85 pregnant women in the second and third trimester were examined: 40 women with normal pregnancy (comparison group) and 45 (main group) with thrombophilia (protein S/protein C deficiency) and subcompensated placental insufficiency. The level of NVL was assessed in blood smears according to the monolayer type using an automatic microscopic system MECOS-C 2. Results . It was found that the level of DNA traps in normal pregnancy and in pregnant women with placental insufficiency at 21–24 weeks of gestation was 1.3 and almost 2 times higher than the level outside pregnancy (p <0.05), with a predominance of phase IIa etosis. By 36–37 weeks, in a normal pregnancy, there was a slight increase in%NVL (16 %), while in the group of pregnant women with placental insufficiency,%NVL increased by 35.7 % compared to the initial data, maintaining a high content of extracellular structures in IIa phase of ethotic transformation (7.4 % versus 5.8 % at 21–24 weeks, p >0.05). Conclusion . It is obvious that the presence of a high level of NIV indicates a failure of immune defense mechanisms and the development of an inadequate inflammatory response in the pathogenesis of fetoplacental insufficiency, which can be useful when carrying out intermediate dynamic monitoring of the condition of a pregnant woman.
的相关性。胎盘功能不全是一种多原因综合征,其特征是违反了胎儿胎盘系统的分子、细胞、组织和器官适应性稳态反应。先天免疫系统的中性粒细胞成分积极参与内皮功能障碍和血栓形成障碍的发展,这是许多妊娠并发症的基础,已被证实,这是开展探索性研究评估不同妊娠阶段孕妇中性粒细胞胞外陷阱(NETs)水平的原因。本研究的目的是确定与血栓形成相关的正常妊娠和胎盘功能不全孕妇中性粒细胞胞外陷阱形成的特征。对85例妊娠中期和晚期的孕妇进行了检查:40例正常妊娠(对照组),45例血栓形成(蛋白S/蛋白C缺乏)和胎盘欠代偿性功能不全(主组)。采用自动显微系统MECOS-C - 2,根据单层类型评估血涂片中NVL的水平。结果。研究发现,21 ~ 24周正常妊娠和胎盘功能不全孕妇的DNA trap水平分别比妊娠外高1.3倍和近2倍(p <0.05),以IIa期异位为主。到36-37周,在正常妊娠中,%NVL略有增加(16%),而在胎盘功能不全的孕妇组中,%NVL比初始数据增加了35.7%,在胚胎转化的IIa期保持了较高的细胞外结构含量(7.4%比21-24周的5.8%,p >0.05)。结论。很明显,在胎儿胎盘功能不全的发病机制中,高水平NIV的存在表明免疫防御机制的失败和炎症反应的不足,这在对孕妇的状况进行中间动态监测时是有用的。
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引用次数: 0
‘Algological bonds of endometriosis’. Features of clinical management of patients with typical and atypical symptoms of endometriosis “子宫内膜异位症的藻类结合”。子宫内膜异位症典型和非典型症状患者的临床处理特点
Pub Date : 2023-11-05 DOI: 10.33667/2078-5631-2023-19-16-22
M. R. Orazov, V. E. Radzinsky, E. D. Dolgov
Endometriosis remains one of the most mysterious and controversial diseases in modern gynecology. Contemporary statistical data demonstrate the extreme relevance of actively implementing effective therapeutic approaches into the clinician’s everyday practice. However, a significant challenge associated with endometriosis is the pain syndrome. The question of so-called atypical algological manifestations of endometriosis, which previously seemed unrelated to the pathogenesis of the primary disease, is increasingly raised. In this regard, the aim of this article was to propose a three-level pathogenetic concept capable of linking the primary manifestation of endometriosis (pelvic pain) with other often distant algological patterns, as well as to create an algorithm for managing these patients based on their pathogenetic staging.
子宫内膜异位症仍然是现代妇科最神秘和有争议的疾病之一。当代统计数据表明,在临床医生的日常实践中积极实施有效的治疗方法是非常重要的。然而,与子宫内膜异位症相关的一个重大挑战是疼痛综合征。所谓的子宫内膜异位症的非典型藻类表现的问题,以前似乎与原发疾病的发病机制无关,越来越多地被提出。在这方面,本文的目的是提出一个三级发病概念,能够将子宫内膜异位症(盆腔疼痛)的主要表现与其他通常遥远的algological模式联系起来,并根据其发病分期创建一个算法来管理这些患者。
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引用次数: 0
Therapeutic and preventive measures in adolescent girls with emerging polycystic ovary syndrome 青春期少女多囊卵巢综合征的治疗和预防措施
Pub Date : 2023-11-05 DOI: 10.33667/2078-5631-2023-19-34-38
I. N. Medvedevа, A. B. Khuraseva, K. S. Svyatchenko, E. N. Strelnikova
Relevance . The manifestation of polycystic ovarian syndrome (PCOS) in adolescence differs significantly from that in adult women and is often hidden under the mask of physiological changes of puberty, which leads to late diagnosis of this disease. However, there is currently there is no convincing and reliable evidence on the advisability of using a number of medications for the treatment of this syndrome in adolescent girls. From this perspective, the first-line therapy inpuberty, with emerging PCOS, is lifestyle modification. Aim : to evaluate the effectiveness of therapeutic lifestyle modification (LSM) and micronutrient support in adolescent girls with PCOS. Materials and Methods . Forty female patients aged 16 to 18 years with a diagnosis of emerging PCOS were included in a prospective study. The patients were divided into 2 groups of 20 subjects each. The 1st group (the main one) – the patients who were recommended to modify their lifestyle in combination with micronutrients (inositol, folic acid, vitamin D, polyunsaturated fatty acids of the omega‑3 family); the 2nd group (the control group) – the girls who were recommended to modify their lifestyle to correct the symptoms of PCOS. The patients’ state was evaluated at the start of treatment, after 3 and 6 months. Results . The best results were seen in Group 1 (LSM +micronutrients) – a statistically significant effect of combined therapy on the metabolic status was found: a decrease in fasting glucose and insulin levels, lower cholesterol levels, normalization of the body mass index; on the hormonal background: a decrease in androstenedione levels, total testosterone, normalization of the LH/FSH ratio, a decrease in the clinical manifestations of hyperandrogenism; on menstrual cycle recovery with spontaneous ovulation. Conclusion . The use of micronutrient support, along with LSM, is an effective means of correcting the clinical manifestations of developing PCOS in adolescent girls, as well as the prevention of the negative effects of the disease.
的相关性。多囊卵巢综合征(PCOS)在青春期的表现与成年女性明显不同,往往隐藏在青春期生理变化的面具下,导致该病诊断较晚。然而,目前还没有令人信服和可靠的证据表明使用一些药物治疗青春期女孩的这种综合征是明智的。从这个角度来看,青春期多囊卵巢综合征的一线治疗方法是改变生活方式。目的:评价治疗性生活方式改变(LSM)和微量营养素支持对青春期女孩多囊卵巢综合征(PCOS)的疗效。材料与方法。40名年龄16至18岁的女性多囊卵巢综合征患者被纳入一项前瞻性研究。将患者分为两组,每组20例。第一组(主要的一组)——建议患者结合微量营养素(肌醇、叶酸、维生素D、omega‑3家族的多不饱和脂肪酸)来改变他们的生活方式;第二组(对照组)-建议改变生活方式以纠正多囊卵巢综合征症状的女孩。在治疗开始时、3个月和6个月后评估患者的状态。结果。结果最好的是第1组(LSM +微量营养素)-发现联合治疗对代谢状态的统计显着影响:空腹血糖和胰岛素水平降低,胆固醇水平降低,体重指数正常化;在激素方面:雄烯二酮水平下降,总睾酮水平下降,LH/FSH比值正常化,雄激素过多的临床表现减少;月经周期恢复与自然排卵。结论。微量营养素支持以及LSM的使用是纠正青春期女孩多囊症临床表现以及预防该疾病负面影响的有效手段。
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引用次数: 0
Effect of the combination of ethinyl oestradiol and chlormadinon acetate on sexuality 炔雌醇与醋酸氯麦迪农合用对性的影响
Pub Date : 2023-11-05 DOI: 10.33667/2078-5631-2023-19-23-32
L. Yu. Karakhalis, A. A. Khalafyan, G. A. Penzhoyan
From the variety of modern methods of hormonal contraception available in the arsenal of the obstetrician-gynecologist, preference is given to those that include gestagen, which not only reduces the clinical manifestations of androgenous dermopathy, but also increases sexual function, at least not affecting it negatively. Such combined oral contraceptives include Belara, containing chlormadinone acetate 2mg, and ethinyl oestradiol 0.03mg. The choice of this drug is justified by previous studies, which evaluated its safety and ability to stop androgenous dermopathy. At the same time, the impact on sexual function was not taken into account in these studies. The purpose of the study was to determine the effect of combined oral contraceptive containing chlormadinone acetate 2mg, and ethinyl oestradiol 0.03mg on sexual function. Material and methods . There were examined 68 patients who were prescribed a combined oral contraceptive containing chlormadinone acetate 2mg, and ethinyl oestradiol 0.03mg (Belara) – one tablet for 21 days daily, followed by a seven-day break. The female sexual function index (FSFI) was investigated in dynamics. Statistical data processing was carried out by STATISTICA 13.3 (Tibco, USA). Results . There were registered the positive effects on sexual health, which consisted in improving all indicators of female sexual function index. Conclusion . The combined oral contraceptive containing chlormadinone acetate 2mg, and ethinyl oestradiol 0.03mg may be recommended to patients with reduced sexual function as a drug of choice, as well as when reducing sexual function on the taking other contraceptives.
在妇产科医生可用的各种现代激素避孕方法中,首选包括孕激素的避孕方法,它不仅可以减少雄激素性皮肤病的临床表现,还可以增加性功能,至少不会对其产生负面影响。这种复方口服避孕药包括Belara,含有2mg醋酸氯麦地那酮和0.03mg炔雌醇。先前的研究评估了这种药物的安全性和阻止雄激素性皮肤病的能力,因此选择这种药物是合理的。同时,在这些研究中并没有考虑到对性功能的影响。本研究的目的是测定醋酸氯麦地那酮2mg与雌二醇0.03mg联合口服避孕药对性功能的影响。材料和方法。研究人员对68名服用复方口服避孕药的患者进行了调查,这些患者服用的复方口服避孕药含有2mg醋酸氯麦地那酮和0.03mg雌二醇(Belara),每天服用一片,连续服用21天,然后休息7天。对女性性功能指数(FSFI)进行动态调查。统计数据处理由STATISTICA 13.3 (Tibco, USA)进行。结果。对性健康产生了积极影响,包括改善了女性性功能指数的所有指标。结论。含醋酸氯麦地那酮2mg、炔雌醇0.03mg的复方口服避孕药可作为性功能减退患者的首选药物,也可在服用其他避孕药具的同时推荐服用。
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Medicinskij alfavit
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