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IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01
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引用次数: 0
Safety and efficacy of budesonide/glycopyrrolate/formoterol fumarate compared with glycopyrrolate/formoterol fumarate for the treatment of COPD: A systematic review and meta-analysis 布地奈德/甘黄罗酸酯/富马酸福莫特罗(BGF)与甘黄罗酸酯/富马酸福莫特罗(GFF)治疗COPD的安全性和有效性:一项系统评价和Meta分析
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01 DOI: 10.1016/j.japh.2025.102906
Piyush Thathera, Aakriti Garg, Shaista Ahmed, Mohd Ashif Khan

Background

Chronic obstructive pulmonary disease (COPD) is a progressive illness characterized by persistent respiratory symptoms and restricted airflow, often owing to smoking and prolonged exposure to environmental irritants. COPD affects the pulmonary vasculature, lung parenchyma, and airways, leading to structural abnormalities such as emphysema. This study compares the safety and effectiveness of budesonide/glycopyrrolate/formoterol fumarate (BGF) metered-dose inhaler (MDI) with glycopyrrolate/formoterol fumarate (GFF) MDI in patients with moderate to severe COPD, focusing on adverse events and forced expiratory volume in 1 second (FEV1).

Methods

A comprehensive literature search was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search encompassed databases such as PubMed, MEDLINE, ClinicalTrials.gov, Cochrane Library, ScienceDirect, Web of Science, and Google Scholar up to April 2024. Search terms included “COPD,” “dual therapies,” “triple therapies,” “LABA,” “LAMA,” “BGF MDI,” “FEV1,” and “COPD exacerbation.” Only English-language randomized controlled trials involving patients aged 40-80 years who were current or former smokers with confirmed COPD were included. In addition, reference lists of included studies were screened. Study quality was assessed using the Cochrane Risk of Bias 2.0 tool.

Results

Through an initial literature review, we obtained 4022 articles, 4 of which were included in the current study. Results showed a statistically significant rise in FEV1 with BGF MDI compared with GFF MDI at 4, 24, and 52 weeks. At 52 weeks, the pooled mean difference in FEV1 was 46.48 mL (95% CI 25.26–67.71). Safety profiles were similar, with adverse events such as nasopharyngitis and upper respiratory tract infections observed in both treatments.

Conclusion

BGF MDI significantly improves lung function compared with GFF MDI in moderate to severe COPD and has a comparable safety profile. Further large-scale studies are needed to confirm long-term safety.
慢性阻塞性肺疾病(COPD)是一种以持续呼吸道症状和气流受限为特征的进行性疾病,通常是由于吸烟和长期暴露于环境刺激物所致。慢性阻塞性肺病显著影响肺血管、肺实质和气道,导致肺气肿等结构异常。本研究比较了布地奈德/甘罗罗酸酯/福莫特罗(BGF) MDI与甘罗罗酸酯/福莫特罗(GFF) MDI在中重度COPD患者中的安全性和有效性,重点关注不良事件和1秒用力呼气量(FEV1)。方法:根据PRISMA指南进行全面的文献检索。搜索包括PubMed、Medline、clinicaltrials.gov、Cochrane Library、ScienceDirect、web of science和b谷歌scholar等数据库,截止到2024年4月。搜索词包括“COPD”、“双重疗法”、“三联疗法”、“LABA”、“LAMA”、“BGF MDI”、“FEV1”和“COPD恶化”。仅纳入了英语随机对照试验(RCTs),涉及年龄在40-80岁、目前或曾经吸烟并确诊为COPD的患者。此外,对纳入研究的参考文献进行筛选。使用Cochrane风险偏倚2.0工具评估研究质量。结果:通过初步文献综述,我们获得4022篇文章,其中最终有4篇文章被纳入本研究。结果显示,与GFF MDI相比,BGF MDI在4、24和52周时的FEV1显著升高。52周时,FEV1的合并平均差值为46.48 mL [95% CI: 25.26;67.71]。两种治疗的安全性相似,均出现鼻咽炎和上呼吸道感染等不良事件。结论:与GFF MDI相比,BGF MDI可显著改善中重度COPD患者的肺功能,且具有相当的安全性。需要进一步的大规模研究来证实其长期安全性。
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引用次数: 0
Creation of the CAP center: Advancing pharmacy practice through implementation science integration 创建CAP中心:通过实施科学整合推进药学实践。
IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2026-01-01 DOI: 10.1016/j.japh.2025.102961
Elizabeth Skoy, Heidi Eukel, Brody Maack, Lisa Nagel, Mark Strand, Amy Werremeyer

Background

Community pharmacies are increasingly recognized for their potential to deliver innovative patient care services. However, implementation of these services is often hindered by barriers. Implementation science (IS) offers a framework to address these challenges, yet its application in pharmacy practice remains limited. North Dakota is a rural state with one school of pharmacy and a unique pharmacy landscape.

Objectives

To describe the creation and impact of the Center for Collaboration and Advancement in Pharmacy (CAP Center), designed to support pharmacies in implementing and sustaining innovative patient care services using IS frameworks such as Practical, Robust Implementation and Sustainability Model and the Reach, Effectiveness, Adoption, Implementation, and Maintenance Model.

Practice description

Launched in 2021, the CAP Center was created by faculty and is focused on the principles of IS to increase uptake and sustainability of pharmacy services to meet patient demand and improve population health.

Practice innovation

The CAP Center operates on 4 core principles: Program and Implementation, Education and Training, Coaching and Support, and Data and Outcomes. It uses the principles of IS to provide guidance, resources, and evaluation strategies to pharmacy teams, by supporting projects from conception through sustainability. The Center's application of IS and the core principles allow for successful implementation of pharmacy services.

Evaluation methods

CAP Center engagement is assessed through metrics such as continuing education credits offered, pharmacy participation, symposium attendance, and project volume. Individual projects are evaluated on adherence to IS principles and implementation outcomes.

Results

Since inception, 93% of North Dakota's community pharmacies have engaged with the CAP Center. Notable projects have demonstrated successful application of IS frameworks, leading to sustainable service delivery and improved patient care.

Conclusion

The CAP Center exemplifies how IS can be operationalized in pharmacy practice to aid in pharmacy program implementation and improve health outcomes. Its model may serve as a blueprint for similar efforts to expand pharmacy services nationwide.
背景:社区药房因其提供创新患者护理服务的潜力而日益受到认可。然而,这些服务的实现常常受到障碍的阻碍。实施科学(IS)为解决这些挑战提供了一个框架,但它在药学实践中的应用仍然有限。北达科他州是一个乡村州,有一所药学院和独特的药房景观。目的:描述药学合作与进步中心(CAP中心)的创建和影响,该中心旨在支持药房使用PRISM和RE-AIM等信息系统框架实施和维持创新的患者护理服务。实践描述:CAP中心于2021年启动,由教师创建,专注于信息系统的原则,以增加药房服务的吸收和可持续性,以满足患者需求并改善人口健康。实践创新:CAP中心的四个核心原则是:计划与实施、教育与培训、指导与支持、数据与成果。它利用信息系统的原则,通过支持从概念到可持续性的项目,为药房团队提供指导、资源和评估策略。中心对信息系统和核心原则的应用使药房服务得以成功实施。评估方法:CAP中心的参与是通过诸如提供的继续教育学分、药房参与、研讨会出席率和项目数量等指标来评估的。对个别项目的评估是基于对信息系统原则的遵守程度和实施结果。结果:自成立以来,北达科他州93%的社区药房与CAP中心合作。一些值得注意的项目已经证明了信息系统框架的成功应用,从而实现了可持续的服务提供和患者护理的改善。结论:CAP中心示范了信息系统如何在药学实践中运作,以帮助药学项目的实施和改善健康结果。它的模式可以作为在全国范围内扩大药房服务的类似努力的蓝图。
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引用次数: 0
期刊
Journal of the American Pharmacists Association
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