Journal of Infection最新文献

{"title":"Identification of a long-standing HIV-1 circulating recombinant form (CRF178_BC) in different high-risk populations along the China-Myanmar border region","authors":"Min Chen , Yanling Ma, , Huichao Chen, Manhong Jia, Wenfei Ding","doi":"10.1016/j.jinf.2025.106477","DOIUrl":"10.1016/j.jinf.2025.106477","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106477"},"PeriodicalIF":14.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid spread of Candida auris in China after COVID-19","authors":"Jian Bing , Yanfeng Huang , Han Du, , Penghao Guo , Junmin Cao, Mei Kang, Clarissa J. Nobile, Guanghua Huang","doi":"10.1016/j.jinf.2025.106476","DOIUrl":"10.1016/j.jinf.2025.106476","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106476"},"PeriodicalIF":14.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-infection dynamics of SARS-CoV-2 and respiratory viruses in the 2022/2023 respiratory season in the Netherlands","authors":"Gesa Carstens ,&nbsp;Eva Kozanli ,&nbsp;Kirsten Bulsink,&nbsp;Scott A. McDonald,&nbsp;Mansoer Elahi,&nbsp;Jordy de Bakker,&nbsp;Maarten Schipper,&nbsp;Rianne van Gageldonk-Lafeber,&nbsp;Susan van den Hof,&nbsp;Albert Jan van Hoek,&nbsp;Dirk Eggink","doi":"10.1016/j.jinf.2025.106474","DOIUrl":"10.1016/j.jinf.2025.106474","url":null,"abstract":"<div><h3>Objectives</h3><div>Evaluation of the presence and effect of SARS-CoV-2 co-infections on disease severity.</div></div><div><h3>Methods</h3><div>We collected both symptom data and nose- and throat samples from symptomatic people during the 2022/2023 respiratory season in a large participatory surveillance study in the Netherlands, and tested these for 18 respiratory viruses, including SARS-CoV-2. We compared reported health status, symptoms and odds of having a single respiratory viral infection or co-infection with SARS-CoV-2 and another respiratory virus.</div></div><div><h3>Results</h3><div>In total, 4655 samples were included with 22% (n=1017) testing SARS-CoV-2 positive. Of these 11% (n=116) also tested positive for a second respiratory virus. The most frequently occurring co-infections in SARS-CoV-2 positive participants were with rhinovirus (59%; n=69), seasonal coronaviruses (15%; n=17), and adenovirus (7%; n=8). Participants with a co-infection with one of these three viruses did not report more severe disease compared to those with a SARS-CoV-2 mono-infection. The odds of experiencing SARS-CoV-2 co-infection with seasonal coronavirus or rhinovirus were lower compared to the odds of the respective non-SARS-CoV-2 mono-infection (OR: 0.16, CI 95%: 0.10 – 0.24; OR: 0.21 CI 95%: 0.17 – 0.26; respectively).</div></div><div><h3>Conclusions</h3><div>SARS-CoV-2 co-infections with rhinovirus, seasonal coronavirus, and adenovirus are frequently observed in the general population, but are not associated with more severe disease compared to SARS-CoV-2 mono-infections. Furthermore, we found indications for inter-virus interaction with rhinovirus and seasonal coronavirus, possibly decreasing the risk of co-infection.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 5","pages":"Article 106474"},"PeriodicalIF":14.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections","authors":"Carla Martín Pérez ,&nbsp;Sílvia Ruiz-Rius ,&nbsp;Anna Ramírez-Morros ,&nbsp;Marta Vidal ,&nbsp;D. Herbert Opi ,&nbsp;Pere Santamaria ,&nbsp;Julià Blanco ,&nbsp;Josep Vidal-Alaball ,&nbsp;James G. Beeson ,&nbsp;Luis M. Molinos-Albert ,&nbsp;Ruth Aguilar ,&nbsp;Anna Ruiz-Comellas ,&nbsp;Gemma Moncunill ,&nbsp;Carlota Dobaño","doi":"10.1016/j.jinf.2025.106473","DOIUrl":"10.1016/j.jinf.2025.106473","url":null,"abstract":"<div><h3>Objectives</h3><div>Repeated COVID-19 mRNA vaccinations increase SARS-CoV-2 IgG4 antibodies, indicating extensive IgG class switching following the first booster dose. This shift in IgG subclasses raises concerns due to the limited ability of IgG4 to mediate Fc-dependent effector functions.</div></div><div><h3>Methods</h3><div>To assess the impact of IgG4 induction on protective immunity, we analyzed longitudinal SARS-CoV-2 IgG subclasses, C1q and FcγR responses, and neutralizing activity in a well-characterized cohort of healthcare workers in Spain.</div></div><div><h3>Results</h3><div>Elevated IgG4 levels and higher ratios of non-cytophilic to cytophilic antibodies after booster vaccination were significantly associated with an increased risk of breakthrough infections (IgG4 HR[10-fold increase]=1.8, 95% CI=1.2–2.7; non-cytophilic to cytophilic ratio HR[10-fold increase]=1.5, 95% CI=1.1–1.9). Moreover, an increased non-cytophilic to cytophilic antibody ratio correlated with reduced functionality, including neutralization.</div></div><div><h3>Conclusions</h3><div>These findings suggest a potential association between IgG4 induction by mRNA vaccination and a higher risk of breakthrough infection, warranting further investigation into vaccination strategies to ensure sustained protection.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106473"},"PeriodicalIF":14.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating lncRNAs as biomarkers for severe dengue using a machine learning approach","authors":"Rodolfo Katz ,&nbsp;Nguyen Minh Nam ,&nbsp;Tulio de Lima Campos ,&nbsp;Victoria Indenbaum ,&nbsp;Sophie Terenteva ,&nbsp;Dinh Thi Thu Hang ,&nbsp;Le Thi Hoi ,&nbsp;Amos Danielli ,&nbsp;Yaniv Lustig ,&nbsp;Eli Schwartz ,&nbsp;Hoang Van Tong ,&nbsp;Ella H. Sklan","doi":"10.1016/j.jinf.2025.106471","DOIUrl":"10.1016/j.jinf.2025.106471","url":null,"abstract":"<div><h3>Objectives</h3><div>Dengue virus (DENV) infection is a significant global health concern, causing severe morbidity and mortality. While many cases present as a mild febrile illness, some progress to life-threatening severe dengue (SD). Early intervention is essential to improve outcomes, but current predictive methods lack specificity, burdening healthcare systems in endemic regions. Circulating long non-coding RNAs (lncRNAs) have emerged as stable and promising biomarkers. This study explored the use of lncRNAs as predictive markers for SD.</div></div><div><h3>Methods</h3><div>Differential expression and qPCR arrays were employed to identify lncRNAs associated with SD. Candidate lncRNAs were validated, and their plasma levels were measured in a cohort of Vietnamese dengue patients (<span><math><mi>n</mi></math></span> =377) and healthy controls (<span><math><mi>n</mi></math></span>=128) at admission. Machine learning algorithms were applied to predict the probability of SD progression.</div></div><div><h3>Results</h3><div>The predictive model demonstrated high sensitivity and specificity, with an area under the curve (AUC) of 0.98 (95% CI: 0.96–1.0). At admission, it accurately identified 17 of 18 patients who later died as high-risk, compared to traditional warning signs, which flagged only 9 of these cases.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that this panel of lncRNAs has the potential to predict SD, which could help reduce healthcare burden and improve patient management in endemic countries.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106471"},"PeriodicalIF":14.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term risk of psychiatric disorders in childhood and adolescence following neonatal invasive group B Streptococcus disease—A Danish cohort study","authors":"Malene Risager Lykke ,&nbsp;Henrik Toft Sørensen ,&nbsp;Joy Elisabeth Lawn ,&nbsp;Erzsébet Horváth-Puhó","doi":"10.1016/j.jinf.2025.106463","DOIUrl":"10.1016/j.jinf.2025.106463","url":null,"abstract":"<div><h3>Objectives</h3><div>The long-term risk of child and adolescent psychiatric disorders (PDs) after neonatal invasive group B <em>Streptococcus</em> disease (iGBS) and the modifying factors are poorly understood.</div></div><div><h3>Methods</h3><div>A population-based matched cohort study, including 1548 infants with iGBS diagnosed during the first 3 months of life from 1997 through 2020 and follow-up until 2022, based on data from Danish national health and administrative registers. A general population comparison cohort of infants without iGBS was randomly sampled and matched 1:10 by sex, the child’s birth year and month, and gestational age (n= 15,345).</div></div><div><h3>Results</h3><div>The cumulative incidence proportion (CIP) with 95% confidence intervals (CIs) of any PD was 21.1% (95% CI 18.7–23.7) in infants exposed to iGBS (88% sepsis, 12% meningitis) and 16.2% (95% CI 15.5–17.0) in the comparison cohort. The 18-year CIP of PD was higher for infants exposed to iGBS meningitis compared to iGBS sepsis. The adjusted hazard ratio for PD in infants with iGBS was 1.41 (95% CI 1.23–1.62).</div></div><div><h3>Conclusions</h3><div>iGBS in early infancy is a risk factor for PDs, especially iGBS meningitis. Premature birth, gestational diabetes, and low maternal education increased the risk of any PD further.</div></div><div><h3>Summary</h3><div>Group B <em>Streptococcus</em> (<em>Streptococcus agalactiae</em>) remains the leading cause of neonatal, invasive disease and is associated with high mortality and risk of neurodevelopmental impairments. Scarce data exist regarding the long-term risk of psychiatric disorders following invasive group B <em>Streptococcus</em> disease in early infancy (iGBS), especially following sepsis. In this Danish national cohort study, we investigated the association of iGBS and the risk of psychiatric disorders until adolescence and early adulthood. We investigated to which extent premature birth, sex (at birth), maternal socioeconomic position or gestational diabetes were modifying the association between iGBS and psychiatric disorders.</div><div>Our study found an increased risk of psychiatric disorders persisting into adolescence following iGBS, including both meningitis and sepsis. Specific psychiatric disorders with elevated risk included anxiety, obsessive-compulsive disorder, autism, and attention deficit hyperactivity disorder. Premature birth, maternal gestational diabetes, and low maternal education further increased the risk of any psychiatric disorders, whereas the child’s sex did not.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106463"},"PeriodicalIF":14.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic chemoprophylaxis for close contacts of invasive group A streptococcus in community settings: Evidence review","authors":"Vicky Watts ,&nbsp;Martine Usdin ,&nbsp;Rachel Mearkle ,&nbsp;Shiranee Sriskandan ,&nbsp;Rebecca Cordery ,&nbsp;Sally Millership ,&nbsp;Vanessa Saliba ,&nbsp;Claire Edmundson ,&nbsp;Anjali Pai ,&nbsp;Colin S. Brown ,&nbsp;Sooria Balasegaram ,&nbsp;Theresa Lamagni ,&nbsp;Valerie Decraene ,&nbsp;The working group for the UK guidelines for the management of contacts of invasive group A streptococcus (iGAS) infection in community settings","doi":"10.1016/j.jinf.2025.106468","DOIUrl":"10.1016/j.jinf.2025.106468","url":null,"abstract":"<div><h3>Objectives</h3><div>Revised UK guidelines for the management of contacts of invasive group A <em>Streptococcus</em> (iGAS) infection in community settings were published in December 2022. We present the findings of a narrative review which informed the public health recommendations around the provision of antibiotic chemoprophylaxis detailed in the updated guidelines.</div></div><div><h3>Methods</h3><div>We conducted a literature review of studies reporting the risk of iGAS infection associated with specific risk factors.</div></div><div><h3>Results</h3><div>There was strong epidemiological evidence for an increased risk of iGAS infection in contacts who are older individuals, post-partum women, neonates and individuals with chickenpox infection; evidence on the impact of influenza co-infection, injecting drug use or being homeless in increasing risk of iGAS infection was less robust.</div></div><div><h3>Conclusions</h3><div>The guidelines made recommendations to offer chemoprophylaxis to close contacts of iGAS cases who are aged ≥75 years, pregnant ≥37 weeks gestation, post-partum, neonates or those with a recent history of, or current chickenpox infection. Systematic data collection evaluating the use of chemoprophylaxis and other control measures is recommended.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106468"},"PeriodicalIF":14.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral ADC189 for adults and adolescents with uncomplicated influenza","authors":"Jingya Zhao ,&nbsp;Guoping Sheng ,&nbsp;Yingqi Lyu ,&nbsp;Yilan Sun ,&nbsp;Sikui Wang ,&nbsp;Xiaolin Chen ,&nbsp;Feng Ye ,&nbsp;Lin Chen ,&nbsp;Xiaowei Xu ,&nbsp;Hong Wang ,&nbsp;Bin Wu ,&nbsp;Chunxian Peng ,&nbsp;Min Deng ,&nbsp;Lihong Qu ,&nbsp;Xuehong Jiang ,&nbsp;Junyan Hu ,&nbsp;Yan Feng ,&nbsp;Yongzhong Li ,&nbsp;Jie Peng ,&nbsp;Weiyang Li ,&nbsp;Jieming Qu","doi":"10.1016/j.jinf.2025.106472","DOIUrl":"10.1016/j.jinf.2025.106472","url":null,"abstract":"<div><h3>Objectives</h3><div>ADC189 is a novel anti-influenza virus inhibitor. In this study, we aimed to evaluate the safety and efficacy of ADC189 in outpatients with uncomplicated influenza infection.</div></div><div><h3>Methods</h3><div>In the phase 2 trial, we assigned patients in a 2:2:1 ratio to receive either single dose 15-mg or 45-mg of ADC189 or placebo. In the phase 3 part, participants were randomized in a 2:1 ratio to receive 45-mg of ADC189 or placebo. The primary endpoint was the time to alleviation of influenza symptoms in the intention-to-treat infected population.</div></div><div><h3>Results</h3><div>In the phase 2 trial that had 150 participants, the median time for virus RNA clearance was shorter in both ADC189 groups (15-mg group, 50·7 h; 45 mg-group, 45·8 h) compared to the placebo group (73·4 h; <em>p</em>=0·69 and 0·016, respectively). 617 participants were enrolled in the phase 3 trial. The median time to symptom alleviation was 50·0 h (95% CI, 44·6 to 59·3) with ADC189, as compared with 68·1 h (95% CI, 62·8 to 84·4) with placebo (<em>p</em>&lt;0·0001). By 1 day after initiation, the decrease in viral load from baseline was greater in the ADC189 group than in the placebo group (2·316 and 1·049 log₁₀ virus copies per milliliter, respectively). Most adverse events were mild or moderate.</div></div><div><h3>Conclusions</h3><div>A single-dose ADC189 shorten the time to the resolution of symptoms among adults and adolescents with uncomplicated influenza, without evident safety concerns.</div><div>(Funded by Jiaxing AnDiCon Biotech Co., Ltd, Zhejiang, China; ChiCTR number, 20230137, and ClinicalTrials. gov number, NCT 06342921.)</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106472"},"PeriodicalIF":14.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged infusion of β-lactam antibiotics for the treatment of febrile neutropenia","authors":"J. Laporte-Amargos,&nbsp;C. Tebé,&nbsp;J. Carratalà,&nbsp;C. Gudiol","doi":"10.1016/j.jinf.2025.106464","DOIUrl":"10.1016/j.jinf.2025.106464","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106464"},"PeriodicalIF":14.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Oropouche virus infection in Matanzas, Cuba, 2024","authors":"Berta María Bello-Rodríguez,&nbsp;Junior Vega-Jiménez ,&nbsp;Roberto Cañete ,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.jinf.2025.106470","DOIUrl":"10.1016/j.jinf.2025.106470","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"90 4","pages":"Article 106470"},"PeriodicalIF":14.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}