Pub Date : 2026-02-01Epub Date: 2025-12-29DOI: 10.1016/j.jinf.2025.106669
Thi Cam Tu Ha , Sheila Orwa , Sandra Guedes , Kelle Moley , Kristin Wannerberger , Anders Elfvin , Martin J. Blaser , Unnur Gudnadottir , Nele Brusselaers
Objectives
To examine the association between prenatal antibiotic exposure and Group B Streptococcus (GBS) disease within 4 weeks postpartum.
Methods
We conducted a population-based cohort study including all singleton live births in Sweden from 2006 to 2016, using national registers. Neonates were classified by prenatal antibiotic exposure status, and GBS disease was ascertained within four weeks postpartum. Adjusted odds ratios (aOR) were estimated using multivariable logistic regression with a robust variance estimator. Effect heterogeneity by GBS risk factors was evaluated, and potential confounding by indication was assessed by additional adjustment for these risk factors.
Results
Among 1,095,644 liveborn singletons, 24.5% were exposed to antibiotics. GBS incidence was higher among exposed neonates than unexposed (0.86 vs. 0.66 per 1000 live births; aOR, 1.29; 95% CI, 1.10–1.50), particularly among neonates without GBS risk factors (aOR, 1.34; 95% CI, 1.12–1.60). The strongest association occurred with early third-trimester exposure (aOR, 1.67; 95% CI, 1.17–2.38). Associations for antibiotics given within four weeks of delivery attenuated after adjustment for GBS risk factors.
Conclusions
Prenatal antibiotic exposure can raise GBS risk within 4 weeks postpartum, especially in neonates not covered by risk-based intrapartum prophylaxis, with the early third-trimester being a critical window of susceptibility.
{"title":"Antibiotic use during pregnancy and neonatal Group B Streptococcus disease","authors":"Thi Cam Tu Ha , Sheila Orwa , Sandra Guedes , Kelle Moley , Kristin Wannerberger , Anders Elfvin , Martin J. Blaser , Unnur Gudnadottir , Nele Brusselaers","doi":"10.1016/j.jinf.2025.106669","DOIUrl":"10.1016/j.jinf.2025.106669","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the association between prenatal antibiotic exposure and Group B Streptococcus (GBS) disease within 4 weeks postpartum.</div></div><div><h3>Methods</h3><div>We conducted a population-based cohort study including all singleton live births in Sweden from 2006 to 2016, using national registers. Neonates were classified by prenatal antibiotic exposure status, and GBS disease was ascertained within four weeks postpartum. Adjusted odds ratios (aOR) were estimated using multivariable logistic regression with a robust variance estimator. Effect heterogeneity by GBS risk factors was evaluated, and potential confounding by indication was assessed by additional adjustment for these risk factors.</div></div><div><h3>Results</h3><div>Among 1,095,644 liveborn singletons, 24.5% were exposed to antibiotics. GBS incidence was higher among exposed neonates than unexposed (0.86 vs. 0.66 per 1000 live births; aOR, 1.29; 95% CI, 1.10–1.50), particularly among neonates without GBS risk factors (aOR, 1.34; 95% CI, 1.12–1.60). The strongest association occurred with early third-trimester exposure (aOR, 1.67; 95% CI, 1.17–2.38). Associations for antibiotics given within four weeks of delivery attenuated after adjustment for GBS risk factors.</div></div><div><h3>Conclusions</h3><div>Prenatal antibiotic exposure can raise GBS risk within 4 weeks postpartum, especially in neonates not covered by risk-based intrapartum prophylaxis, with the early third-trimester being a critical window of susceptibility.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106669"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-20DOI: 10.1016/j.jinf.2026.106694
Michal Frantisek Kriha, Jan Kamis, Marketa Dvorakova, Luc Tardy, Jana Elsterova, Dana Teislerova, Ales Chrdle, Martin Palus, Daniel Ruzek, Vaclav Hönig
{"title":"Response to: Comment on: Detection of tick-borne encephalitis virus RNA in patient samples at different stages of infection","authors":"Michal Frantisek Kriha, Jan Kamis, Marketa Dvorakova, Luc Tardy, Jana Elsterova, Dana Teislerova, Ales Chrdle, Martin Palus, Daniel Ruzek, Vaclav Hönig","doi":"10.1016/j.jinf.2026.106694","DOIUrl":"10.1016/j.jinf.2026.106694","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106694"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: Detection of tick-borne encephalitis virus RNA in patient samples at different stages of infection","authors":"Xiaoli Jiang, Mei Cha, Qin Zhang, Wenxu Yang, Erdan Luo, Wenjie Qing","doi":"10.1016/j.jinf.2026.106687","DOIUrl":"10.1016/j.jinf.2026.106687","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106687"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-08DOI: 10.1016/j.jinf.2026.106681
Daryl Geers , Muriel Aguilar-Bretones , Luca M. Zaeck , Paul A. Gill , Cristina Gonzalez-Lopez , Kim Handrejk , Ngoc H. Tan , Yvette den Hartog , Lennert Gommers , Susanne Bogers , Anna Z. Mykytyn , Roos S.G. Sablerolles , Abraham Goorhuis , Douwe F. Postma , Leo G. Visser , Virgil A.S.H. Dalm , Melvin Lafeber , Neeltje A. Kootstra , Debbie van Baarle , Bart L. Haagmans , Rory D. de Vries
Objectives
Ongoing escape from pre-existing antibodies by severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) necessitates yearly coronavirus disease 2019 (COVID-19) vaccine updates. Monovalent variant-specific booster vaccines for at-risk populations aim to re-direct antibody responses towards antigenically distinct variants. However, multiple past exposures to the ancestral SARS-CoV-2 spike (S) protein through vaccination and infection could hinder the de novo induction of variant-specific immune responses.
Methods
Here, we profiled SARS-CoV-2-specific antibody, T- and B-cell responses in healthcare workers up to 6 months after monovalent XBB.1.5 vaccination.
Results
Neutralizing antibodies targeting Omicron subvariants circulating at the time of vaccination were preferentially boosted by vaccination but remained lower than those neutralizing the ancestral strain. Similar responses were observed for antibodies that mediate functionality through antibody-dependent cellular cytotoxicity, although these responses were more promiscuous. Broadly S-reactive B-cells were recalled by vaccination, with limited de novo induction of XBB.1.5-specific B-cell clones. B-cells targeting the receptor binding domain of circulating Omicron subvariants were favored, and T-cell responses cross-reacted with all SARS-CoV-2 variants that were assessed.
Conclusions
Combined, this comprehensive immune profiling demonstrates that despite evidence of imprinted antibody responses targeting ancestral S, monovalent booster vaccination skews the immune response to Omicron lineage recognition.
{"title":"Preferential boosting of SARS-CoV-2 Omicron lineage-specific immune responses by monovalent XBB.1.5 vaccination","authors":"Daryl Geers , Muriel Aguilar-Bretones , Luca M. Zaeck , Paul A. Gill , Cristina Gonzalez-Lopez , Kim Handrejk , Ngoc H. Tan , Yvette den Hartog , Lennert Gommers , Susanne Bogers , Anna Z. Mykytyn , Roos S.G. Sablerolles , Abraham Goorhuis , Douwe F. Postma , Leo G. Visser , Virgil A.S.H. Dalm , Melvin Lafeber , Neeltje A. Kootstra , Debbie van Baarle , Bart L. Haagmans , Rory D. de Vries","doi":"10.1016/j.jinf.2026.106681","DOIUrl":"10.1016/j.jinf.2026.106681","url":null,"abstract":"<div><h3>Objectives</h3><div>Ongoing escape from pre-existing antibodies by severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) necessitates yearly coronavirus disease 2019 (COVID-19) vaccine updates. Monovalent variant-specific booster vaccines for at-risk populations aim to re-direct antibody responses towards antigenically distinct variants. However, multiple past exposures to the ancestral SARS-CoV-2 spike (S) protein through vaccination and infection could hinder the <em>de novo</em> induction of variant-specific immune responses.</div></div><div><h3>Methods</h3><div>Here, we profiled SARS-CoV-2-specific antibody, T- and B-cell responses in healthcare workers up to 6 months after monovalent XBB.1.5 vaccination.</div></div><div><h3>Results</h3><div>Neutralizing antibodies targeting Omicron subvariants circulating at the time of vaccination were preferentially boosted by vaccination but remained lower than those neutralizing the ancestral strain. Similar responses were observed for antibodies that mediate functionality through antibody-dependent cellular cytotoxicity, although these responses were more promiscuous. Broadly S-reactive B-cells were recalled by vaccination, with limited <em>de novo</em> induction of XBB.1.5-specific B-cell clones. B-cells targeting the receptor binding domain of circulating Omicron subvariants were favored, and T-cell responses cross-reacted with all SARS-CoV-2 variants that were assessed.</div></div><div><h3>Conclusions</h3><div>Combined, this comprehensive immune profiling demonstrates that despite evidence of imprinted antibody responses targeting ancestral S, monovalent booster vaccination skews the immune response to Omicron lineage recognition.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106681"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-09DOI: 10.1016/j.jinf.2026.106680
Matteo RICCO', Claudio COSTANTINO, Paolo MANZONI, Antonio BALDASSARRE, Gianluca Pasquale GIURI, Antonio CASCIO
{"title":"Respiratory syncytial virus and healthcare workers, an unmet need? Insights from SIREN study and systematic review of available evidence","authors":"Matteo RICCO', Claudio COSTANTINO, Paolo MANZONI, Antonio BALDASSARRE, Gianluca Pasquale GIURI, Antonio CASCIO","doi":"10.1016/j.jinf.2026.106680","DOIUrl":"10.1016/j.jinf.2026.106680","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106680"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study”","authors":"Kanishka Harariya, Thakur Rohit Singh, Ankita Kalra, Swarupanjali Padhi, Fayaz Ahamed","doi":"10.1016/j.jinf.2025.106670","DOIUrl":"10.1016/j.jinf.2025.106670","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106670"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145858917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-12DOI: 10.1016/j.jinf.2026.106689
Andreas Widmer , Nadine Imhasly , Christian Brand , Vilijam Zdravkovi , Adrian Spoerri , Kurt Schmidlin , Melanie Wicki , Martin Beck , Rami Sommerstein , for SIRIS and SWISSNOSO
Objective
Evaluate long-term mortality and the role of causative pathogens in periprosthetic joint infection (PJI) following total hip arthroplasty (THA).
Methods
Retrospective nationwide cohort study of adults undergoing THA (2012–2022) using data from the Swiss Joint Registry, Center for Infection Prevention and civil registry. Primary outcome was up to 10-year survival with or without PJI. Adjusted hazard ratios (aHR) were estimated via Gompertz regression, controlling for sex, age, BMI, and ASA. Pathogen-specific mortality hazard was analyzed.
Results
Of 215,678 patients, 89,709 met inclusion criteria (51.3% women; median age 69 years). PJI occurred in 745 (0.8%) patients, 2 752 (3.1%) underwent aseptic revision. PJI was associated with increased mortality (aHR 2.15; 95% CI, 1.79–2.57; p<0.001) compared to no PJI/revision, aseptic revisions were not (aHR 0.92; 95% CI, 0.80–1.06; p=0.27). Pathogens associated with increased mortality included Enterobacterales (aHR 3.17; 95% CI, 2.09–4.83, p<0.001), Staphylococcus aureus (aHR 2.32; 95% CI, 1.65–3.27; p<0.001), Cutibacterium acnes (aHR 2.31; 95% CI, 1.20–4.45; p=0.01), and coagulase-negative staphylococci (aHR 1.65; 95% CI, 1.16–2.35; p=0.006). Streptococcal infections showed no significant association (aHR 1.24; 95% CI, 0.62–2.49; p=0.54).
Conclusion
PJI following THA was associated with an approximately twofold increase in long-term mortality hazard. C. acnes presented an unexpectedly high mortality hazard.
{"title":"Increased long-term mortality of patients with prosthetic joint infection after primary total hip arthroplasty – A large observational cohort study","authors":"Andreas Widmer , Nadine Imhasly , Christian Brand , Vilijam Zdravkovi , Adrian Spoerri , Kurt Schmidlin , Melanie Wicki , Martin Beck , Rami Sommerstein , for SIRIS and SWISSNOSO","doi":"10.1016/j.jinf.2026.106689","DOIUrl":"10.1016/j.jinf.2026.106689","url":null,"abstract":"<div><h3>Objective</h3><div>Evaluate long-term mortality and the role of causative pathogens in periprosthetic joint infection (PJI) following total hip arthroplasty (THA).</div></div><div><h3>Methods</h3><div>Retrospective nationwide cohort study of adults undergoing THA (2012–2022) using data from the Swiss Joint Registry, Center for Infection Prevention and civil registry. Primary outcome was up to 10-year survival with or without PJI. Adjusted hazard ratios (aHR) were estimated via Gompertz regression, controlling for sex, age, BMI, and ASA. Pathogen-specific mortality hazard was analyzed.</div></div><div><h3>Results</h3><div>Of 215,678 patients, 89,709 met inclusion criteria (51.3% women; median age 69 years). PJI occurred in 745 (0.8%) patients, 2 752 (3.1%) underwent aseptic revision. PJI was associated with increased mortality (aHR 2.15; 95% CI, 1.79–2.57; p<0.001) compared to no PJI/revision, aseptic revisions were not (aHR 0.92; 95% CI, 0.80–1.06; p=0.27). Pathogens associated with increased mortality included Enterobacterales (aHR 3.17; 95% CI, 2.09–4.83, p<0.001), <em>Staphylococcus aureus</em> (aHR 2.32; 95% CI, 1.65–3.27; p<0.001), <em>Cutibacterium acnes</em> (aHR 2.31; 95% CI, 1.20–4.45; p=0.01), and coagulase-negative staphylococci (aHR 1.65; 95% CI, 1.16–2.35; p=0.006). Streptococcal infections showed no significant association (aHR 1.24; 95% CI, 0.62–2.49; p=0.54).</div></div><div><h3>Conclusion</h3><div>PJI following THA was associated with an approximately twofold increase in long-term mortality hazard. <em>C. acnes</em> presented an unexpectedly high mortality hazard.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106689"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2025-12-30DOI: 10.1016/j.jinf.2025.106672
Tomasz Wybranowski, Marta Napiórkowska-Mastalerz, Kamila Dybowska, Ewa Żekanowska, Stefan Kruszewski, Grzegorz Przybylski
{"title":"Butyrylcholinesterase as an overlooked prognostic biomarker of 100-day mortality in non-COVID CAP","authors":"Tomasz Wybranowski, Marta Napiórkowska-Mastalerz, Kamila Dybowska, Ewa Żekanowska, Stefan Kruszewski, Grzegorz Przybylski","doi":"10.1016/j.jinf.2025.106672","DOIUrl":"10.1016/j.jinf.2025.106672","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106672"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01Epub Date: 2026-01-14DOI: 10.1016/j.jinf.2026.106686
Eloïse Le Banner , Joseph Le Moulec , Mallorie Kerjouan , Vincent Grosbost , Antoine Parrot , Murielle Rondeau-Lutz , Vanessa Leguy Seguin , Christian Lavigne , Anne Contis , Morgane Mourguet , Shirine Mohamed , Étienne-Marie Jutant , Sandra Blivet , Johana Pradelli , Olivier Espitia , Laurent Chaussavoine , Sabine Revuz , Matthieu Revest , Pierre Tattevin , Sophie Dupuis-Girod , David Luque Paz
Objectives
Patients with hereditary hemorrhagic telangiectasia (HHT) present increased risk of severe infections. Studies focusing on infections in HHT population are scarce. We aimed to assess characteristics and outcomes of infections in patients with HHT.
Methods
A retrospective study was conducted in a nationwide cohort of 4502 HHT patients. Patients with HHT hospitalized for infection across 16 referral centers in France between 2010 and 2024 were identified, and data were collected through a standardized questionnaire.
Results
We included 163 HHT patients (median age, 60 years [49–69], 52% male), who experienced a total of 249 bacterial infections. One third (n=53/163) experienced recurrent infections requiring hospitalization. Infections caused by Staphylococcus aureus were reported in 80 patients representing 107 episodes of infection. Brain abscesses were reported in 43 patients representing 51 episodes, often despite prior pulmonary arteriovenous malformations embolization (n=17/43). In multivariable analysis, factors associated with 1-year mortality (n=27/163, 17%) were age (aHR=1.06, 95%CI:1.01–1.16) and infective endocarditis (aHR=2.88, 95%CI:1.10–7.87).
Conclusions
In this HHT cohort, severe infections were predominantly due to S. aureus, far ahead of brain abscesses caused by oral bacteria. Considering the high rate of recurrent infections, further studies focusing on prophylaxis strategies in HHT patients are needed.
{"title":"A contemporary picture of bacterial infections in patients with hereditary hemorrhagic telangiectasia: A nationwide cohort study","authors":"Eloïse Le Banner , Joseph Le Moulec , Mallorie Kerjouan , Vincent Grosbost , Antoine Parrot , Murielle Rondeau-Lutz , Vanessa Leguy Seguin , Christian Lavigne , Anne Contis , Morgane Mourguet , Shirine Mohamed , Étienne-Marie Jutant , Sandra Blivet , Johana Pradelli , Olivier Espitia , Laurent Chaussavoine , Sabine Revuz , Matthieu Revest , Pierre Tattevin , Sophie Dupuis-Girod , David Luque Paz","doi":"10.1016/j.jinf.2026.106686","DOIUrl":"10.1016/j.jinf.2026.106686","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with hereditary hemorrhagic telangiectasia (HHT) present increased risk of severe infections. Studies focusing on infections in HHT population are scarce. We aimed to assess characteristics and outcomes of infections in patients with HHT.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted in a nationwide cohort of 4502 HHT patients. Patients with HHT hospitalized for infection across 16 referral centers in France between 2010 and 2024 were identified, and data were collected through a standardized questionnaire.</div></div><div><h3>Results</h3><div>We included 163 HHT patients (median age, 60 years [49–69], 52% male), who experienced a total of 249 bacterial infections. One third (n=53/163) experienced recurrent infections requiring hospitalization. Infections caused by <em>Staphylococcus aureus</em> were reported in 80 patients representing 107 episodes of infection. Brain abscesses were reported in 43 patients representing 51 episodes, often despite prior pulmonary arteriovenous malformations embolization (n=17/43). In multivariable analysis, factors associated with 1-year mortality (n=27/163, 17%) were age (aHR=1.06, 95%CI:1.01–1.16) and infective endocarditis (aHR=2.88, 95%CI:1.10–7.87).</div></div><div><h3>Conclusions</h3><div>In this HHT cohort, severe infections were predominantly due to <em>S. aureus,</em> far ahead of brain abscesses caused by oral bacteria. Considering the high rate of recurrent infections, further studies focusing on prophylaxis strategies in HHT patients are needed.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"92 2","pages":"Article 106686"},"PeriodicalIF":11.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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