Journal of Infection最新文献

{"title":"SARS-CoV-2 spike-specific IgG4 class switching associates with clinical recovery in Long COVID","authors":"Kaori Sano, Yayoi Kimura, Koichi Hirahata, Hideaki Kato, Hideki Hasegawa, Hidenori Akutsu, Akihide Ryo, Atsushi Goto, Kei Miyakawa","doi":"10.1016/j.jinf.2025.106641","DOIUrl":"10.1016/j.jinf.2025.106641","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106641"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood donors as sentinels for genomic surveillance of West Nile virus in Germany using a sensitive amplicon-based sequencing approach","authors":"Gábor Endre Tóth ,&nbsp;Marike Petersen ,&nbsp;Francois Chevenet ,&nbsp;Marcy Sikora ,&nbsp;Alexandru Tomazatos ,&nbsp;Alexandra Bialonski ,&nbsp;Heike Baum ,&nbsp;Balázs Horváth ,&nbsp;Padet Siriyasatien ,&nbsp;Anna Heitmann ,&nbsp;Stephanie Jansen ,&nbsp;Ruth Offergeld ,&nbsp;Raskit Lachmann ,&nbsp;Michael Schmidt ,&nbsp;Jonas Schmidt-Chanasit ,&nbsp;Dániel Cadar","doi":"10.1016/j.jinf.2025.106647","DOIUrl":"10.1016/j.jinf.2025.106647","url":null,"abstract":"<div><h3>Background</h3><div>West Nile virus (WNV) has emerged as a public health concern in Germany since its first detection in 2018, with evidence of expanding geographic spread. Genomic surveillance is critical for tracking viral evolution, identifying introductions, and monitoring local transmission. However, genome recovery from low-viremia samples such as those obtained through blood donor screening remains technically challenging.</div></div><div><h3>Aim</h3><div>To develop and validate a sensitive amplicon-based sequencing protocol optimized for WNV lineage 2 and apply it to low-titer samples to support genomic surveillance in Germany.</div></div><div><h3>Methods</h3><div>A novel primer scheme was designed for WNV lineage 2 and applied to 43 nucleic acid testing (NAT)-positive blood donor samples collected between 2020 and 2024. Amplicon-based sequencing performance was benchmarked against metagenomic next-generation sequencing (mNGS). Recovered genomes were subjected to phylogenomic analysis to assess viral diversity and transmission dynamics.</div></div><div><h3>Results</h3><div>The amplicon protocol enabled genome recovery (&gt;70% coverage) from samples with viral loads as low as ∼10¹ RNA copies/µL, outperforming metagenomic NGS (mNGS). Of the 43 samples, 30 yielded complete or near-complete genomes. Six distinct WNV subclades (2A–2F), including German strains, were identified, indicating multiple introductions into Germany from Central Europe. Subclade 2F emerged as the dominant and widely distributed group. Berlin, Brandenburg, Saxony, and Saxony-Anhalt were identified as persistent transmission hubs.</div></div><div><h3>Conclusion</h3><div>This study highlights blood donors as valuable sentinels for WNV genomic surveillance. The validated amplicon-based sequencing approach enables sensitive, scalable genome recovery from low-viremia samples, and when integrated with routine blood donor screening, provides a robust framework for early detection, transmission dynamics, and public health preparedness.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106647"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of a high-risk Enterobacter hormaechei ST78 clone from hospital wastewater co-harboring blaNDM-4, tmexCD2-toprJ2, and mcr-9.2: Convergence of last-resort antimicrobial resistance genes","authors":"Hao Guo ,&nbsp;Nanqi Zhang ,&nbsp;Qiao Li ,&nbsp;Yawen Zhang,&nbsp;Wenping Lin,&nbsp;Fang He","doi":"10.1016/j.jinf.2025.106640","DOIUrl":"10.1016/j.jinf.2025.106640","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106640"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145418039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target product profile and discovery and development path for novel cryptococcal disease treatments","authors":"David B. Meya ,&nbsp;Manu De Rycker ,&nbsp;Ian H. Gilbert ,&nbsp;William Hope ,&nbsp;Justine Jelagat Odionyi ,&nbsp;Michael Keegan ,&nbsp;Angela Loyse ,&nbsp;Pablo Moral-Lopez ,&nbsp;Peter R. Williamson ,&nbsp;Lionel K. Tan ,&nbsp;Isabela Ribeiro ,&nbsp;Timothy J. Miles","doi":"10.1016/j.jinf.2025.106643","DOIUrl":"10.1016/j.jinf.2025.106643","url":null,"abstract":"<div><div><em>Cryptococcus neoformans</em> and <em>Cryptococcus gattii</em> are World Health Organization critical and medium priority pathogens, respectively. These mainly impact people with human immunodeficiency virus residing in low- and middle-income countries, but other patient groups and settings are also affected. The high global morbidity and mortality and the limitations of current treatments provided an impetus for the development of a target product profile (TPP) for new anti-cryptococcal agents. Key attributes of the TPP include improved safety, superior (or at least comparable) activity to current treatments against all syndromes across the full disease spectrum (cryptococcal meningitis, cryptococcal pneumonia, etc.), relevance for <em>C. neoformans</em> and <em>C. gattii</em>, suitability for all age groups, oral and intravenous formulations, an acceptable treatment regimen, minimal/manageable drug-drug interactions, thermostability, and a barrier to resistance at least as high as current options. The aim of this TPP, along with the suggested discovery and development paths, is to assist all stakeholders in the development of novel cryptococcal disease treatments.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106643"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From HSV-2 to HSV-1: A change in the epidemiology of genital herpes","authors":"Sabina Andreu ,&nbsp;Daniel Galdo-Torres ,&nbsp;Inés Ripa ,&nbsp;Oliver Caballero ,&nbsp;Raquel Bello-Morales ,&nbsp;José Antonio López-Guerrero","doi":"10.1016/j.jinf.2025.106636","DOIUrl":"10.1016/j.jinf.2025.106636","url":null,"abstract":"<div><div>Genital herpes (GH), historically associated with herpes simplex virus type 2 (HSV-2), is changing its etiology. Since the last few decades, there has been an increase in genital infections caused by herpes simplex virus type 1 (HSV-1). In fact, in several countries, preferably in high-income regions such as North America or Western Europe, HSV-1 has become the leading cause of first-episode GH, especially among adolescents and young adults. However, the epidemiological trend varies geographically, with slower changes observed in Africa, Latin America, and Southeast Asia, where GH HSV-2 remains dominant. This epidemiological shift may be mainly due to the decline in HSV-1 seroprevalence, decreased childhood exposure to the virus, and changes in sexual practices. Despite the global decline in HSV-1 seroprevalence, GH caused by HSV-1 is rising by 1–2% annually in many areas. This review summarizes the seroprevalence of HSV-1/-2 worldwide in recent decades and discusses the changes in GH etiology and contributing factors. Despite the substantial global burden of the disease and its psychosocial impact, no vaccine or curative treatment exists. Active surveillance, health and sexual health education, and targeted interventions are vital to manage this changing landscape and to mitigate the public health issue posed by GH and HSV-1.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106636"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of colorectal cancer in patients with Enterococcus faecalis blood stream infection: A nationwide study","authors":"L. Østergaard ,&nbsp;A. Dahl ,&nbsp;S. Chamat-Hedemand ,&nbsp;A. Stahl ,&nbsp;M.M. Pries-Heje ,&nbsp;C. Moser ,&nbsp;K.K. Søgaard ,&nbsp;C.N. Agergaard ,&nbsp;K.K. Mortensen ,&nbsp;K. Iversen ,&nbsp;H. Bundgaard ,&nbsp;M. Voldstedlund ,&nbsp;L. Køber ,&nbsp;N.E. Bruun ,&nbsp;E.L. Fosbøl","doi":"10.1016/j.jinf.2025.106644","DOIUrl":"10.1016/j.jinf.2025.106644","url":null,"abstract":"<div><h3>Background</h3><div>Some studies have suggested an association between <em>Enterococcus faecalis</em> blood stream infection (BSI) and colorectal cancer (CRC) suggesting that screening for CRC could be reasonable. However, these studies were limited by small numbers with low generalizability.</div></div><div><h3>Methods</h3><div>Danish nationwide registries were used to identify patients with first-time <em>E. faecalis</em> BSI from 2010 to 2021 without previous colorectal neoplasia (CRN). Age-, sex- and calendar-matched comparators from the general population were identified (1:5). We estimated the six-month cumulative incidence of CRC and CRN and a multivariable adjusted Cox analysis was used for relative comparison between groups.</div></div><div><h3>Results</h3><div>We identified 4664 patients with <em>E. faecalis</em> BSI (median age: 74.9 years, 73.4% males) and 23,320 comparators from the general population. For patients with <em>E. faecalis</em> BSI the six-month incidence of CRC was 0.45% (95% CI: 0.28–0.72%) and of CRN 2.34% (95% CI: 1.88–2.88). For matched comparators the incidence of CRC was 0.12% (95% CI: 0.08–0.17) and of CRN 0.48% (95% CI: 0.39–0.57). In adjusted analysis, patients with <em>E. faecalis</em> BSI had a higher HR of CRC (HR=3.70 (95% CI: 1.91–7.19) and CRN (HR=4.64 (95% CI: 3.40–6.34) than matched comparators. The six-month mortality was 36.3% in patients with E. faecalis BSI while this was 1.7% among comparators.</div></div><div><h3>Conclusion</h3><div>In patients with first-time <em>E. faecalis</em> BSI the six months incidence of CRC was around 0.5% and 2.3% for the diagnosis of CRN, which were 3–4 times higher than in a matched cohort from the general population. Nevertheless, the absolute risks do not justify systematic screening for CRC or CRN in patients with <em>E. faecalis</em> BSI.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106644"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for persistent candidemia and prognostic implications: Results from the ECMM Candida III study","authors":"Sarah Sedik ,&nbsp;Matthias Egger ,&nbsp;Stella Wolfgruber ,&nbsp;Jon Salmanton-García ,&nbsp;Matteo Bassetti ,&nbsp;Malgorzata Mikulska ,&nbsp;Volkan Özenci ,&nbsp;Sevtap Arikan-Akdagli ,&nbsp;Murat Akova ,&nbsp;Jean-Pierre Gangneux ,&nbsp;Alessandra Bandera ,&nbsp;Ana Alastruey-Izquierdo ,&nbsp;Aleksandra Barac ,&nbsp;Riina Rautemaa-Richardson ,&nbsp;Nick A. de Jonge ,&nbsp;Laura Loughlin ,&nbsp;Ola Blennow ,&nbsp;Fanny Lanternier ,&nbsp;Eelco F.J. Meijer ,&nbsp;Nina Khanna ,&nbsp;Martin Hoenigl","doi":"10.1016/j.jinf.2025.106629","DOIUrl":"10.1016/j.jinf.2025.106629","url":null,"abstract":"<div><h3>Objectives</h3><div>Candidemia is a severe complication in critically ill and immunocompromised patients, and is associated with high morbidity and mortality. While early fungal clearance may improve outcomes, the association between follow-up blood culture (FUBCs) results and clinical outcomes remains insufficiently explored. This sub-analysis of the ECMM <em>Candida</em> III study investigates predictors of persistent candidemia and the impact of positive FUBC results on clinical outcomes.</div></div><div><h3>Methods</h3><div>The multicenter ECMM <em>Candida</em> III study enrolled adults with culture-proven candidemia from 60 European centers (2018–2019). This sub-analysis included patients with at least one FUBC result reported (n = 258; 40.8%). Statistical analysis used SPSS 29 and R. Binary logistic regression was used to identify predictors of persistent candidemia. To assess mortality risk factors, Cox proportional hazards regression models were constructed.</div></div><div><h3>Results</h3><div>Of 258 patients, 52 (20.2%) had persistent candidemia based on positive FUBCs (median duration of candidemia 6 days). Utilization of echinocandins as first line treatment was less frequent (61.5% vs. 78.2%; p=0.014) in those with positive FUBCs. Mortality was significantly higher in the FUBC-positive group (50% vs. 32%; p=0.016). In the multivariable logistic regression model, lower EQUAL <em>Candida</em> Scores, reflecting reduced adherence to guideline-recommended management, were independently associated with persistent candidemia (OR 0.003, 95% CI 0.0002–0.07; p&lt;0.001). Univariable Cox regression identified persistent candidemia ≥5 days (HR 2.16; 95% CI 1.33–3.53; p= 0.002) as a significant predictor of mortality. In the multivariable Cox regression model, intensive care unit (ICU) admission (HR 1.59, 95% CI 1.02–2.50; p= 0.039) and persistent candidemia ≥5 days (HR 2.06, 95% CI 1.26–3.37; p= 0.004) remained independent predictors of mortality.</div></div><div><h3>Conclusion</h3><div>Persistent candidemia was predicted by poor adherence to treatment guidelines, as shown by low EQUAL <em>Candida</em> Scores, particularly due to the lack of initial echinocandin use. After controlling immortal time bias, persistent candidemia ≥5 days and ICU admission remained independent predictors of mortality in the multivariable model.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106629"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bictegravir/emtricitabine/tenofovir alafenamide for primary HIV infection: Efficacy, safety and impact on viral reservoir (the BIC-PHI clinical trial)","authors":"Juan Ambrosioni ,&nbsp;Elisa de Lazzari ,&nbsp;Sonsoles Sánchez-Palomino ,&nbsp;Lucía Bailón ,&nbsp;Paula Suanzes ,&nbsp;Carmen Busca ,&nbsp;Luis Ramos-Ruperto ,&nbsp;Eva Orviz ,&nbsp;Ángel Rivero ,&nbsp;Beatriz Mothe ,&nbsp;Jorge Del Romero ,&nbsp;Vicenç Falcó ,&nbsp;Sònia Vicens-Artés ,&nbsp;Elisa Moraga ,&nbsp;Anna Cruceta ,&nbsp;Josep Mallolas ,&nbsp;Josep M. Miró ,&nbsp;the BIC-PHI Study Group","doi":"10.1016/j.jinf.2025.106651","DOIUrl":"10.1016/j.jinf.2025.106651","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the efficacy, safety and impact on viral reservoir of rapid bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) initiation during primary HIV infection (PHI).</div></div><div><h3>Methods</h3><div>Multicenter, single-arm clinical trial in participants with PHI of &lt;3 months (seroconversion or incomplete serological pattern), starting BIC/FTC/TAF in 6 Spanish centers between January-2021 and September-2022. Primary endpoint was proportion of participants with viral load (VL)&lt;50 copies/mL at 48-weeks on the Intention-to-treat-exposed population (ITTe). Cases were compared with randomly-matched retrospective PHI controls, starting other 3-drug Integrase-Strand-Transfer-inhibitor-based regimens. Reservoir was evaluated in PHI cases by Intact Proviral DNA Assay (IPDA).</div></div><div><h3>Results</h3><div>We included 64 participants, 94% cis-male, aged 32 (26;41) years.; 78% men-who-have-sex-with-men. At BIC/FTC/TAF initiation, Fiebig stages were II (14%), III (11%); IV (5%), V (54%) and VI (16%); VL was 496,520 (110,000;1,285,000) copies/mL; 62% were subtype B; median (IQR) CD4 T cell count was 406 (322;535) cells/µL; 6% had active hepatitis B virus co-infection. All participants started BIC/FTC/TAF at first specialist consultation. 81% (ITTe) and 93% (On-Treatment, OT) had VL&lt;50 copies/mL at 48-weeks. 72% had adverse events, only 3% were grade 3/4; 91% were not-related, none led to BIC/FTC/TAF-discontinuation. 92% of controls (OT) had VL&lt;50 copies/mL at 48-weeks (p=0.914), 11% (17%) modified initial antiretroviral regimen (p&gt;0.001). Intact and defective proviral DNA levels significantly decreased at 48-weeks.</div></div><div><h3>Conclusions</h3><div>BIC/FTC/TAF showed rapid viral decay, high suppression rates, good tolerability, and reservoir decline in PHI, making it an appealing regimen in this setting.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106651"},"PeriodicalIF":11.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current global trends in meningococcal disease control, risk groups and vaccination: Consensus of the Global Meningococcal Initiative","authors":"Ray Borrow ,&nbsp;Dominque A. Caugant ,&nbsp;Stephen A. Clark ,&nbsp;Ener Çagri Dinleyici ,&nbsp;Ian Hall ,&nbsp;Lee H. Harrison ,&nbsp;William P. Hausdorff ,&nbsp;Shamez N. Ladhani ,&nbsp;Jay Lucidarme ,&nbsp;Marco A.P. Sáfadi ,&nbsp;Vinny Smith ,&nbsp;Muhamed-Kheir Taha ,&nbsp;Julio Vázquez","doi":"10.1016/j.jinf.2025.106635","DOIUrl":"10.1016/j.jinf.2025.106635","url":null,"abstract":"<div><div>This review outlines recent trends on invasive meningococcal disease (IMD) discussed at the latest meeting of the Global Meningococcal Initiative (GMI). There has been a re-emergence of the Hajj strain sublineage (serogroup W; ST-11 clonal complex), with travel to the Kingdom of Saudi Arabia being a critical factor in transmission. The epidemiology of IMD has also changed following the COVID-19 pandemic, with annual IMD cases increasing in many countries. For example, the highest number of IMD cases since 2014 was reported in the USA in 2023–2024. Atypical presentations of IMD have been prominent irrespective of the pandemic. For instance, an increase in cases of meningococcal epiglottitis has been reported in France in 2022–2023 (serogroups W and Y). When considering vaccination, the GMI has identified a need for broader meningococcal serogroup B (MenB) immunisation owing to the potential impact of the vaccines on reducing IMD incidence caused by other serogroups than MenB. There is also a case for using MenB vaccination to protect against <em>Neisseria gonorrhoeae</em> infection based on initial evidence, albeit further studies will need to be conducted.</div></div>","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106635"},"PeriodicalIF":11.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of a second-generation HIV-1 circulating recombinant form (CRF177_0708) in different risk populations in Yunnan, China","authors":"Min Chen,&nbsp;Huichao Chen,&nbsp;Yanling Ma,&nbsp;Manhong Jia,&nbsp;Wenfei Ding","doi":"10.1016/j.jinf.2025.106633","DOIUrl":"10.1016/j.jinf.2025.106633","url":null,"abstract":"","PeriodicalId":50180,"journal":{"name":"Journal of Infection","volume":"91 5","pages":"Article 106633"},"PeriodicalIF":11.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}