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International Journal of Technology Management最新文献

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High-Bit-Rate Transmission in Visible Light Communication System Based on Adaptive Successive Interference Cancellation Technique 基于自适应逐次干扰抵消技术的可见光通信系统高比特率传输
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.5966
Brian Pamukti, Amirullah Wijayanto, S. Liaw
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引用次数: 0
Balancing Efficacy and Tolerability of First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Network Meta-Analysis. 平衡晚期肝细胞癌一线系统疗法的疗效和耐受性:一项网络 Meta 分析。
IF 13.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 eCollection Date: 2024-04-01 DOI: 10.1159/000531744
Ciro Celsa, Giuseppe Cabibbo, David James Pinato, Gabriele Di Maria, Marco Enea, Marco Vaccaro, Salvatore Battaglia, Giacomo Emanuele Maria Rizzo, Paolo Giuffrida, Carmelo Marco Giacchetto, Gabriele Rancatore, Maria Vittoria Grassini, Calogero Cammà

Background: Atezolizumab + bevacizumab represent the current standard of care for first-line treatment of advanced hepatocellular carcinoma (HCC). However, direct comparison with other combination treatments including immune checkpoint inhibitors (ICI) + tyrosine kinase inhibitors (TKIs) are lacking.

Objectives: This network meta-analysis (NMA) aims to indirectly compare the efficacy and the safety of first-line systemic therapies for unresectable advanced HCC.

Method: A literature search of MEDLINE, Embase, and SCOPUS databases was conducted up to October 31, 2022. Phase 3 randomized controlled trials (RCTs) testing TKIs, including sorafenib and lenvatinib, or ICIs reporting overall survival (OS) and progression-free survival (PFS) were included. Individual survival data were extracted from OS and PFS curves to calculate restricted mean survival time. A Bayesian NMA was performed to compare treatments in terms of efficacy (15- and 30-month OS, 6-month PFS) and safety, represented by grade ≥3 (severe) adverse events (SAEs). The incremental safety-effectiveness ratio as measure of net health benefit was calculated as the difference in SAE probability divided by survival difference between the 2 most effective treatments.

Results: Nine RCTs enrolling 6,600 patients were included. Atezolizumab plus bevacizumab showed the highest probability (88%) of achieving the 30-month OS landmark. Lenvatinib showed a probability of 86% of achieving best PFS outcomes. ICI monotherapies ranked as most tolerable. Atezolizumab plus bevacizumab showed the best net health benefit for OS, compared to durvalumab plus tremelimumab. When evaluating the net health benefit for PFS, at a willingness-to-risk threshold of 10% of SAEs for life-month gained, atezolizumab plus bevacizumab was favoured in 78% of cases, while at threshold of 30% of SAEs for life-month gained, lenvatinib was favoured in 76% of cases.

Conclusions: Atezolizumab plus bevacizumab is the best treatment in terms of net benefit and therefore it should be recommended as standard of care. Compared to atezolizumab plus bevacizumab, lenvatinib monotherapy had the best net benefit for PFS when physicians and patients are available to accept a higher risk of toxicity.

背景:阿特珠单抗+贝伐单抗是目前一线治疗晚期肝细胞癌(HCC)的标准疗法。然而,目前还缺乏与其他联合疗法(包括免疫检查点抑制剂(ICI)+酪氨酸激酶抑制剂(TKIs))的直接比较:本网络荟萃分析(NMA)旨在间接比较不可切除晚期HCC一线系统疗法的疗效和安全性:方法:对截至2022年10月31日的MEDLINE、Embase和SCOPUS数据库进行文献检索。方法:检索了截至2022年10月31日的MEDLINE、Embed和SCOPUS数据库中的文献,包括测试索拉非尼、来伐替尼等TKIs或报告总生存期(OS)和无进展生存期(PFS)的ICIs的3期随机对照试验(RCT)。从OS和PFS曲线中提取单个生存数据,计算限制性平均生存时间。进行了贝叶斯NMA,以比较各种疗法的疗效(15个月和30个月OS、6个月PFS)和安全性(以≥3级(严重)不良事件(SAE)表示)。作为衡量净健康获益的增量安全有效性比的计算方法是:SAE概率的差异除以两种最有效疗法的生存期差异:结果:共纳入了9项研究,6,600名患者接受了治疗。阿特珠单抗加贝伐单抗达到30个月OS里程碑的概率最高(88%)。伦伐替尼实现最佳PFS结果的概率为86%。ICI 单一疗法的耐受性最好。与durvalumab加tremelimumab相比,Atezolizumab加贝伐单抗在OS方面显示出最佳的净健康效益。在评估PFS的净健康获益时,以10%的SAEs为生命月获益的风险意愿阈值,78%的病例选择了阿特珠单抗加贝伐单抗,而以30%的SAEs为生命月获益的风险意愿阈值,76%的病例选择了来伐替尼:结论:就净获益而言,阿特珠单抗联合贝伐单抗是最佳治疗方案,因此应将其推荐为标准治疗方案。与阿特珠单抗联合贝伐珠单抗相比,在医生和患者都能接受较高毒性风险的情况下,来伐替尼单药治疗的净疗效最好。
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引用次数: 0
Catalytic Cracking Column Scheme Modernization for Efficient Utilization of Thermal Energy 高效利用热能的催化裂化塔方案现代化
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.5560
Fedyukhin Alexander Valerievich, Boltysheva Margarita Igorevna, Sitas Viktor Ivanovich, Savostikov Artem Evgenievich, Dremicheva Elena Sergeevna, Akhmetova Irina Gareevna
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引用次数: 0
Tobacco Extract for Inhibition of Carbon Steel Corrosion in H2S-contained NaCl Solution 烟草提取物在含硫化氢NaCl溶液中对碳钢的缓蚀作用
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.5272
H. Devianto, I. Nurdin, P. Widiatmoko, Della Silvia, Clarissa Prakarsa
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引用次数: 0
A Novel Hybrid Spotted Hyena Optimizer: An Algorithm for Fuel Consumption Capacitated Vehicle Routing Problem 一种新型混合斑鬣狗优化器:一种燃油消耗能力车辆路径问题的算法
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.5148
D. M. Utama, Aminatul Yurifah, A. Garside
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引用次数: 1
Development of Zirconia Reinforced AA7075/AA7050 Aluminum Chip-Based Composite Processed Using Hot Press Forging Method 热压锻造氧化锆增强AA7075/AA7050铝片基复合材料的研制
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.6032
Yahya M. Altharan, S. Shamsudin, Sami. Al-Alimi, Mohammed A. Jubair
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引用次数: 0
Role of Risk Management and Standardization for supporting Innovation in New Normal based on Lessons Learned during Pandemic COVID-19 基于COVID-19大流行期间的经验教训,风险管理和标准化在支持新常态创新中的作用
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.5299
B. Prasetya, Yopi Yopi, B. Tampubolon
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引用次数: 0
Performance Analysis of Combined Gas-Electric Steam Turbine System as Main Propulsion for Small-scale LNG Carrier Ships 小型LNG运输船主推进气电汽轮机联合系统性能分析
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.6149
M. A. Budiyanto, Sultan Alif Zidane, Gerry Liston Putra, Achmad Riadi, Riezqa Andika, G. Theotokatos
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引用次数: 0
Defining Healthy City and Its Influence on Urban Well-being 健康城市的定义及其对城市幸福感的影响
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.6578
Y. Whulanza, E. Kusrini
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引用次数: 1
Study of Solid–Liquid Extraction Kinetics of Oil from Dried Avocado (Persea Americana) Flesh Using Hexane as A Solvent 以己烷为溶剂固液萃取牛油果(Persea Americana)果肉油的动力学研究
IF 2.8 4区 管理学 Q2 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2023-07-25 DOI: 10.14716/ijtech.v14i5.6370
S. Satriana, Amrina Maulida, Rizky Qardhawi, Y. M. Lubis, R. Moulana, W. Mustapha, N. Arpi
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引用次数: 0
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International Journal of Technology Management
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