Researchers can incorporate uncertainties in computational fluid dynamics (CFD) that go beyond the inaccuracies caused by numerical discretization thanks to stochastic simulations. This study confirms the validity of current stochastic modeling tools by providing examples of stochastic simulations in conjunction with numerical solutions for incompressible flows. A numerical technique for solving deterministic and stochastic models is developed in this work. Our approach employs the Euler-Maruyama method for stochastic modeling, representing a stochastic version of the third-order explicit-implicit scheme. For the deterministic model, the scheme is third-order accurate. The consistency and stability of the constructed scheme are provided in the mean square sense. The scheme is the predictor–corrector type that is built on two time levels. Moreover, a mathematical model of the Casson nanofluid flow with variable thermal conductivity is given with the effect of the chemical reaction. The appropriate transformations are used to condense the set of partial differential equations (PDEs) down to one that is dimensionless. The scheme is applied for the deterministic and stochastic models of dimensionless flow problems. The velocity profile's deterministic and stochastic behavior are shown using contour plots. Results show that growing values of the thermal mixed convection parameter enhance the velocity profile. This article presents the progress made in stochastic computational fluid dynamics (SCFD) and highlights the energy-related aspects of our discoveries. Our computational approach and stochastic modeling techniques provide new insights into the energy properties of Casson nanofluid flow, specifically regarding the variability of thermal conductivity and chemical processes. Our objective is to clarify the complex interaction of these factors on energy dynamics. This article presents a contemporary summary of the latest SCFD advancements. Additionally, it highlights potential directions for future research and unresolved issues that require attention from the members of the field of computational mathematics.