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Presence of antibody against the inducible Hsp71 in patients with acute heat-induced illness. 急性热诱发疾病患者体内存在针对可诱导 Hsp71 的抗体。
IF 3.8 Pub Date : 2001-04-01 DOI: 10.1379/1466-1268(2001)006<0113:poaati>2.0.co;2
T Wu, S Chen, C Xiao, C Wang, Q Pan, Z Wang, M Xie, Z Mao, Y Wu, R M Tanguay

Antibodies against heat shock or stress proteins (Hsps) have been reported in a number of diseases in which they may be involved in the pathogenesis of the disease or may be of use for prognosis. Heat-induced diseases, such as heat cramps, heat exhaustion, or heat stroke, are frequent in hot working or living environments. There are still few investigations on the presence and possible significance of autoantibodies against Hsps in heat-induced illnesses. Using an immunoblotting technique with recombinant human Hsps, we analyzed the presence and titers of antibodies against Hsp60, Hsp71, and Hsp90alpha, and Hsp90beta in a group of 42 young male patients who presented with acute heat-induced illness during training. We also examined the presence of antibody against Hsp71 in a second group of 57 patients with acute heat-induced illness and measured the changes in titers of anti-Hsp71 antibodies in 9 patients hospitalized by emergency physicians. In the first group of young persons exercising in a hot environment, the occurrence of antibodies against Hsp71 and Hsp90alpha was significantly higher among individuals with symptoms of heat-induced illness (P < 0.05) than in the matched group of nonaffected exercising individuals. Moreover titers of antibody against Hsp71 were higher in individuals of the severe and mild heat-induced illness groups, the highest titer being found in the most severe cases. The results from the second group of 57 heat-affected patients exposed to extreme heat were similar. Again, patients with the more severe heat-induced symptoms showed a significantly higher incidence of antibodies to Hsp71 than controls and the titer of anti-Hsp71 was higher in the severely affected group. Finally, in a study of 9 patients, it was observed that the titer of anti-Hsp71 decreased during recovery from severe heat symptoms. These results suggest that measurement of antibodies to Hsps may be useful in assessing how individuals are responding to abnormal stress within their living and working environment and may be used as one biomarker to evaluate their susceptibility to heat-induced diseases.

热休克或应激蛋白(Hsps)抗体在许多疾病中都有报道,这些抗体可能与疾病的发病机制有关,也可能对预后有帮助。热引起的疾病,如热痉挛、热衰竭或中暑,在炎热的工作或生活环境中很常见。关于热引起的疾病中是否存在针对Hsps的自身抗体及其可能的意义的研究仍然很少。我们使用重组人Hsps的免疫印迹技术,分析了一组42名在训练中出现急性热诱发疾病的年轻男性患者体内Hsp60、Hsp71、Hsp90alpha和Hsp90beta抗体的存在和滴度。我们还检测了第二组 57 名急性热诱发疾病患者体内 Hsp71 抗体的存在情况,并测量了 9 名急诊住院患者体内抗 Hsp71 抗体滴度的变化。在第一组在高温环境下运动的年轻人中,出现热诱发疾病症状的人体内的 Hsp71 和 Hsp90alpha 抗体的出现率(P < 0.05)明显高于匹配的未受影响的运动人群。此外,Hsp71 抗体的滴度在严重和轻度热诱发疾病组中都较高,滴度最高的是最严重的病例。第二组 57 名受极端高温影响的热病患者的结果与此类似。同样,热诱发症状较重的患者体内 Hsp71 抗体的发生率明显高于对照组,且严重患者组的抗 Hsp71 滴度较高。最后,在一项针对 9 名患者的研究中观察到,抗 Hsp71 滴度在严重高温症状恢复期间有所下降。这些结果表明,Hsps 抗体的测定可能有助于评估个人对生活和工作环境中异常压力的反应,并可作为一种生物标志物来评估他们对热引起的疾病的易感性。
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引用次数: 0
Risk perception and cigar smoking behavior. 风险认知与吸雪茄行为
IF 2.3 Pub Date : 2001-03-01 DOI: 10.5993/ajhb.25.2.3
F Baker, J T Dye, M M Denniston, S R Ainsworth

Objective: To examine the cigar smoking perceptions and behaviors of US adults.

Methods: A national sample of 1,012 adults was interviewed by telephone.

Results: Current cigar smokers differed from nonsmokers in perceptions of personal risk for cancer and views about cigar smoking as a cancer cause. Both groups showed substantial acceptance of the glamorized image of cigarsmokers.

Conclusion: Although recognizing smoking as a cancer cause in general, cigar smokers tended to show a self-exempting "optimistic bias" with regard to perceptions of their own risks.

目的研究美国成年人对吸食雪茄的看法和行为:方法:通过电话对全国 1,012 名成年人进行了抽样调查:结果:目前抽雪茄的人与不抽雪茄的人在对个人患癌风险的认识和对抽雪茄是致癌原因的看法上有所不同。两组人都对雪茄客的美化形象表现出极大的认同:结论:尽管雪茄吸食者普遍认为吸烟是致癌的原因之一,但在对自身风险的认识上,他们往往表现出一种自我豁免的 "乐观偏见"。
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引用次数: 44
Living from Hand to Mouth 勉强糊口
Pub Date : 1999-01-01 DOI: 10.1021/ie50104a005
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引用次数: 13
New Relationships 新关系
Pub Date : 1997-01-01 DOI: 10.1021/ie50158a846
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引用次数: 0
AIR POLLUTION CONTROL 空气污染控制
Pub Date : 1993-01-01 DOI: 10.1021/i650568a759
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引用次数: 0
The Race Is Not Always to the Swift 比赛并不总是一帆风顺
Pub Date : 1987-01-01 DOI: 10.1021/ie50134a006
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引用次数: 9
Mercury Poisoning 汞中毒
Pub Date : 1980-01-01 DOI: 10.1021/ie50045a029
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引用次数: 0
Diffusion of Oils in Asphalts 油在沥青中的扩散
Pub Date : 1974-03-01 DOI: 10.1021/I360049A013
J. Oliver
THE RATE AT WHICH TRITIUM-TAGGED DODECYLBENZEN PENETRATED THREE ASPHALT SAMPLES WAS FOLLOWED BY THINLY SLICING THE ASPHALTS AND MEASURING THE DECREASE OF RADIOACTIVITY WITH DEPTH. DIFFUSION RATE COULD BE INCREASED BY ADDING DILUENT OR RAISING THE TEMPERATURE BUT WAS UNAFFECTED BY THE PRESENCE OF A LEACHED PHOTOOXIDATION SKIN ON THE ASPHALT SURFACE. ONLY AN AVERAGE DIFFUSION COEFFICIENT COULD BE DETERMINED FOR COMMERCIAL OIL FRACTION PENETRANTS BECAUSE CONSTITUENTS OF DIFFERENT SIZE AND MOLECULAR CONFIGURATION DIFFUSED AT DIFFERENT RATES. REJUVENATION OF OLD ASPHALT ROADS BY OVERSPRAYING WITH SUCH OILS WOULD TAKE PLACE SLOWLY AND CAN ONLY BE EFFECTIVE IF THE OIL IS PROTECTED FROM TRAFFIC BY ABSORPTION INTO PORES PRESENT IN THE PAVEMENT SURFACE. /AUTHOR/
氚标记的十二烷基苯穿透三种沥青样品的速率是通过将沥青薄切片并测量放射性随深度的下降。扩散速率可以通过添加稀释剂或提高温度来增加,但不受沥青表面存在浸出的光氧化表皮的影响。由于不同粒径和分子构型的渗透剂扩散速率不同,因此对商品含油渗透剂只能确定平均扩散系数。通过过度喷洒这种油来恢复旧的沥青道路将会缓慢地进行,并且只有在石油被吸收到路面表面的孔隙中以防止交通的情况下才能有效。/作者/
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引用次数: 41
Editorial. What's in a Name? 社论名字里有什么?
Pub Date : 1974-01-01 DOI: 10.1021/ie50100a003
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引用次数: 1
CALCULATION OF EQUILIBRIUM COMPOSITION OF AUTOMOTIVE EXHAUST GASES 汽车尾气平衡成分的计算
Pub Date : 1973-07-17 DOI: 10.1021/I260047A032
R. Grosso
The influence of temperature (600 to 1500 K), pressure (1 to 60 atm), and air/fuel ratio (13.0 to 17.0) on the equilibrium composition of automotive exhaust gas is calculated by minimizing the total free energy with the assumption that the outlet components are known. Nitrogen oxides, principally as nitric oxide, appear to be formed in combustion chamber zones with high temperatures (1800 to 2000 K) and relatively high air/fuel ratios. Nitrogen oxide elimination, although easier in a reducing atmosphere, appears also possible in an oxidizing atmosphere. Ammonia formation, although negligible in the combustion chamber, appears significant at operating conditions of a highly efficient reducing catalyst. Its formation is favored at low temperatures and high pressures if the air/fuel ratio is less than stoichiometric or at high temperatures if the air/fuel ratio is greater than than stoichiometric. Carbon monoxide concentration decreases with increasing air/fuel ratios and increases with the temperature for a fixed air/fuel ratio. Its concentration is determined not only by the water-gas shift reaction but also by other reactions. The most oxidation-resistant hydrocarbons are methane, acetylene, ethylene, and benzene. Among the aldehydes, formaldehyde shows the highest concentrations for the oxidized hydrocarbon fraction.
温度(600至1500 K)、压力(1至60 atm)和空气/燃料比(13.0至17.0)对汽车废气平衡成分的影响是在假设出口成分已知的情况下,通过最小化总自由能来计算的。氮氧化物,主要是一氧化氮,似乎在高温(1800至2000 K)和相对较高的空气/燃料比的燃烧室区域形成。氮氧化物的消除虽然在还原性气氛中比较容易,但在氧化性气氛中似乎也是可能的。氨的形成虽然在燃烧室中可以忽略不计,但在高效还原性催化剂的操作条件下却显得很重要。如果空气/燃料比小于化学计量量,则有利于在低温和高压下形成;如果空气/燃料比大于化学计量量,则有利于在高温下形成。一氧化碳浓度随着空气/燃料比的增加而降低,在空气/燃料比固定的情况下随着温度的升高而升高。它的浓度不仅由水气转换反应决定,而且由其他反应决定。最抗氧化的碳氢化合物是甲烷、乙炔、乙烯和苯。在醛类中,甲醛在氧化烃馏分中浓度最高。
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引用次数: 0
期刊
Industrial and Engineering Chemistry
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