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In Memoriam: Murray Grossman, EdD, MD: Cognitive and Behavioral Neurology Mourns the Loss of a Leader in the Field. 《记忆》:Murray Grossman,EdD,医学博士:认知与行为神经病学哀悼失去一位该领域的领导者。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000343
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引用次数: 0
All That Moves Us: A Pediatric Neurosurgeon, His Young Patients, and Their Stories of Grace and Resilience. 《感动我们的一切》:一位儿科神经外科医生,他的年轻患者,以及他们的优雅和坚韧故事。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000327
Howard S Kirshner
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引用次数: 0
Acute Mania and Psychosis in the Context of Primary Adrenal Insufficiency: A Systematic Review of the Literature. 原发性肾上腺功能不全背景下的急性躁狂和精神病:文献的系统回顾。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000340
Andrew Ovakimyan, Neal A Patel, Nolan J Brown, Taylor Reardon, Gianna Fote, Julian Gendreau

Background: Given the sparse nature of acute mania or psychosis in primary adrenal insufficiency (PAI), physicians may not be aware of the association of these two entities.

Objective: To conduct a systematic review of the literature for the purpose of identifying all studies reporting mania and/or psychosis in individuals with PAI.

Method: We conducted a systematic review according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using the PubMed, Embase, and Web of Science databases from June 22, 1970 to June 22, 2021, for the purpose of identifying all studies reporting instances of mania or psychosis associated with PAI.

Results: We identified nine case reports featuring nine patients (M age = 43.3 years, male = 44.4%) over eight countries that fit our inclusion/exclusion criteria. Eight (89%) of the patients had experienced psychosis. Manic and/or psychotic symptom resolution was achieved in 100% of the cases, of which steroid replacement therapy was efficacious in seven (78%) cases and was sufficient in six (67%).

Conclusion: Acute mania and psychosis in the context of PAI is a very rare presentation of an already uncommon disease. Resolution of acute psychiatric change is reliably achieved with the correction of underlying adrenal insufficiency.

背景:考虑到原发性肾上腺功能不全(PAI)中急性躁狂或精神病的稀疏性,医生可能不知道这两种疾病之间的联系。目的:对文献进行系统综述,以确定所有报告PAI患者躁狂和/或精神病的研究,目的是确定所有报告与PAI相关的躁狂或精神病病例的研究。结果:我们确定了9份病例报告,其中9名患者(M年龄=43.3岁,男性=44.4%)来自8个国家,符合我们的纳入/排除标准。8名(89%)患者曾经历过精神病。躁狂和/或精神病症状100%得到缓解,其中类固醇替代疗法在7例(78%)中有效,在6例(67%)中足够。结论:PAI背景下的急性躁狂和精神病是一种非常罕见的疾病。通过纠正潜在的肾上腺功能不全,可以可靠地解决急性精神病变化。
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引用次数: 0
The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity. 脑卒中后主观感觉超敏的神经解剖学。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000341
Hella Thielen, Nora Tuts, Christophe Lafosse, Céline Raymond Gillebert

Background: Although subjective sensory hypersensitivity is prevalent after stroke, it is rarely recognized by health care providers, and its neural mechanisms are largely unknown.

Objective: To investigate the neuroanatomy of poststroke subjective sensory hypersensitivity as well as the sensory modalities in which subjective sensory hypersensitivity can occur by conducting both a systematic literature review and a multiple case study of patients with subjective sensory hypersensitivity.

Method: For the systematic review, we searched three databases (Web of Science, PubMed, and Scopus) for empirical articles discussing the neuroanatomy of poststroke subjective sensory hypersensitivity in humans. We assessed the methodological quality of the included studies using the case reports critical appraisal tool and summarized the results using a qualitative synthesis. For the multiple case study, we administered a patient-friendly sensory sensitivity questionnaire to three individuals with a subacute right-hemispheric stroke and a matched control group and delineated brain lesions on a clinical brain scan.

Results: Our systematic literature search resulted in four studies (describing eight stroke patients), all of which linked poststroke subjective sensory hypersensitivity to insular lesions. The results of our multiple case study indicated that all three stroke patients reported an atypically high sensitivity to different sensory modalities. These patients' lesions overlapped with the right anterior insula, the claustrum, and the Rolandic operculum.

Conclusion: Both our systematic literature review and our multiple case study provide preliminary evidence for a role of the insula in poststroke subjective sensory hypersensitivity and suggest that poststroke subjective sensory hypersensitivity can occur in different sensory modalities.

背景:尽管主观感觉超敏反应在中风后很普遍,但它很少被卫生保健提供者所认识,其神经机制也在很大程度上不为人知。目的:通过系统的文献回顾和对主观感觉超敏患者的多病例研究,研究脑卒中后主观感觉超敏感的神经解剖学以及主观感觉超敏感性可能发生的感觉模式。方法:为了进行系统综述,我们在三个数据库(Web of Science、PubMed和Scopus)中搜索了讨论人类脑卒中后主观感觉超敏反应神经解剖学的实证文章。我们使用病例报告关键评估工具评估了纳入研究的方法学质量,并使用定性综合总结了结果。在多病例研究中,我们对三名亚急性右半球卒中患者和一个匹配的对照组进行了一份对患者友好的感觉敏感性问卷调查,并在临床脑部扫描中描绘了脑部病变。结果:我们的系统文献检索导致了四项研究(描述了八名中风患者),所有这些研究都将中风后主观感觉超敏反应与岛叶病变联系起来。我们的多病例研究结果表明,所有三名中风患者都报告了对不同感觉模式的异常高敏感性。这些患者的病变与右前脑岛、幽闭和Rolandic盖重叠。结论:我们的系统文献综述和多个病例研究都为脑岛在卒中后主观感觉超敏反应中的作用提供了初步证据,并表明卒中后主观感官超敏反应可能以不同的感觉模式发生。
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引用次数: 0
Understanding the Relationship Between Perseveration, Comorbid Behavioral Symptoms, Motor Decline, Functional Decline, and Self-report Accuracy in Huntington Disease Can Help Inform Clinical Practice. 了解亨廷顿舞蹈症患者的毅力、共病行为症状、运动能力下降、功能下降和自我报告准确性之间的关系有助于为临床实践提供信息。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000331
Andy M Liu, Erin Koppel, Karen E Anderson

Background: Perseveration is one of the most debilitating symptoms of Huntington disease (HD).

Objective: To study perseveration and its relationship to comorbid behavioral symptoms, motor decline, functional decline, and subject self-report accuracy by analyzing cross-sectional data tracking individuals who have or are at risk for HD and healthy controls (HC).

Method: We studied 96 individuals from HD families and 35 HC who were either family controls or gene negative. We used χ 2 tests to compare patient demographic and survey outcomes data and to analyze the presence of obsessions and compulsions (OC), depression, and apathy relative to the presence of perseveration.

Results: Individuals with HD and perseveration had a higher presence of OC, depression, and apathy compared with individuals with HD of the same stages without perseveration (19%, 47.6%, and 47.6% vs 15%, 40%, and 25%, respectively). In addition, individuals in HD Stages 1-3 with higher motor scores (showing a later stage of disease) displayed a significantly higher rate of perseveration than the HC ( P = 0.0476; P = 0.0499, respectively). The presence of an informant resulted in a significantly higher rate of perseveration reporting for individuals in HD Stages 1 and 2 (41.2% and 53.8% with informant vs 23.5% and 11.1% without informant, respectively).

Conclusion: Perseveration was seen across all motor and functional stages for the individuals with HD, without significant differences between the different stages. Additionally, informants were beneficial to obtaining accurate patient reports of perseveration. These findings should prove useful for physician evaluation and treatment considerations.

背景:毅力是亨廷顿舞蹈症(HD)最令人衰弱的症状之一。目的:通过分析追踪患有或有HD风险的个体和健康对照(HC)的横断面数据,研究持续性及其与共病行为症状、运动能力下降、功能下降和受试者自我报告准确性的关系。方法:我们研究了来自HD家族的96名个体和35名HC,他们要么是家族对照,要么是基因阴性。我们使用χ2检验来比较患者的人口统计和调查结果数据,并分析强迫症(OC)、抑郁和冷漠的存在与坚持的存在之间的关系。结果:与未坚持的同阶段HD患者相比,患有HD并坚持的患者OC、抑郁和冷漠的存在率更高(分别为19%、47.6%和47.6%,而非15%、40%和25%)。此外,HD 1-3期运动评分较高(显示疾病后期)的个体表现出明显高于HC的坚持率(分别为P=0.0476和P=0.0499)。对于HD第1和第2阶段的个体,有线人的存在导致了显著更高的坚持报告率(有线人时分别为41.2%和53.8%,而没有线人时则分别为23.5%和11.1%)。结论:HD患者在所有运动和功能阶段都表现出毅力,不同阶段之间没有显著差异。此外,知情者有利于获得准确的患者坚持报告。这些发现应该被证明对医生的评估和治疗考虑是有用的。
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引用次数: 1
Memory for the News: Does Event Transience Matter? 新闻记忆:事件的短暂性重要吗?
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000333
Caroline O Nester, Christopher Malone, Catherine Munro, Nancy Madigan, Sara Hoffschmidt, Joan Sweeney, Tyler Zink, Margaret O'Connor

Background: Health providers frequently probe patients' recall of current and/or remote news events to determine the extent of memory loss. Impaired memory for transient events (ie, in the news for a circumscribed time) may provide information regarding the onset of cognitive impairment.

Objective: To use the Transient News Events Test (TNET) to explore how memory changes over time in both older adults with cognitive impairment (CI) and noncognitively impaired (NCI) older adults. We also investigated the role of episodic and semantic memory on TNET performance.

Method: Sixty-seven older adults completed the TNET as part of a comprehensive neuropsychological assessment. Analyses included t tests to evaluate group differences for TNET score and correlations between TNET and neuropsychological measures, including episodic and semantic memory tests.

Results: NCI adults demonstrated better memory for TNET items than adults with CI. The NCI and CI groups did not differ regarding memory for remote events; however, the CI group exhibited worse memory for recent events. There was a significant association between TNET score and the capacity for episodic and semantic memory in the CI group. In the NCI group, TNET score was significantly associated with episodic memory.

Conclusion: Findings support the use of transient news events to assess remote memories in older adults. Novel remote memory measures broaden the scope of memory assessment far beyond what is feasible with traditional neuropsychological assessment and may provide insight into the onset of memory changes.

背景:卫生服务提供者经常调查患者对当前和/或远程新闻事件的回忆,以确定记忆丧失的程度。短暂事件记忆受损(即在限定时间内出现在新闻中)可能提供有关认知障碍发作的信息。目的:使用瞬态新闻事件测试(TNET)来探索患有认知障碍(CI)和非认知障碍(NCI)的老年人的记忆如何随时间变化。我们还研究了情景记忆和语义记忆对TNET表现的作用。方法:67名老年人完成了TNET,作为综合神经心理学评估的一部分。分析包括t检验,以评估TNET评分的组间差异以及TNET与神经心理学测量之间的相关性,包括情景记忆和语义记忆测试。结果:NCI成人对TNET项目的记忆优于CI成人。NCI组和CI组对远程事件的记忆没有差异;然而,CI组对最近的事件表现出较差的记忆力。CI组的TNET评分与情景记忆和语义记忆能力之间存在显著相关性。在NCI组中,TNET评分与情景记忆显著相关。结论:研究结果支持使用瞬时新闻事件来评估老年人的远程记忆。新的远程记忆测量拓宽了记忆评估的范围,远远超出了传统神经心理学评估的可行性,并可能提供对记忆变化开始的深入了解。
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引用次数: 0
Using the LASSI-L to Detect Robust Interference Effects in Premanifest Huntington Disease. 使用LASSI-L检测亨廷顿舞蹈症前期的稳健干扰效应。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000329
Luis A Sierra, Clementina J Ullman, Samuel A Frank, Simon Laganiere

Background: Diagnosis of manifest Huntington disease (HD) is based primarily on motor symptoms, but premanifest HD (preHD) is often associated with subtle cognitive decline. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) is a validated verbal learning test that can be used to detect early cognitive decline.

Objective: To determine the utility of the LASSI-L for detecting early cognitive decline in individuals with preHD and to compare the results of the LASSI-L with those of commonly used neuropsychological tests in HD.

Method: We administered the LASSI-L to 13 individuals with preHD and 13 healthy controls matched for age, sex, and education as part of a longitudinal study of disease progression. For comparison purposes, we administered the Mini-Mental State Examination; Stroop Color and Word Test; Symbol Digit Modalities Test; Trail-Making Test, Parts A and B; and category fluency (animals) task.

Results: Five of the seven sections on the LASSI-L captured group differences: Proactive Semantic Interference (PSI; P < 0.001), Failure to Recover From PSI ( P = 0.038), Retroactive Semantic Interference (RSI; P = 0.013), Delayed Recall ( P < 0.001), and B1 Cued Recall Intrusions ( P = 0.036). Using a false discovery rate of <0.05, PSI, RSI, and Delayed Recall remained significant.

Conclusion: The LASSI-L is a sensitive instrument for detecting early interference effects in individuals with preHD that outperforms commonly used neuropsychological tests. The LASSI-L could be a useful addition to clinical and research protocols involving individuals with preHD.

背景:明显的亨廷顿舞蹈症(HD)的诊断主要基于运动症状,但出现症状前的HD(preHD)通常与细微的认知能力下降有关。Loewenstein-Acevedo语义干扰和学习量表(LASSI-L)是一种经过验证的言语学习测试,可用于检测早期认知能力下降。目的:确定LASSI-L在检测HD前期患者早期认知能力下降中的作用,并将LASSI-L的结果与HD常用的神经心理学测试结果进行比较。方法:作为疾病进展纵向研究的一部分,我们对13名HD前期患者和13名年龄、性别和教育程度匹配的健康对照组进行了LASSI-L治疗。为了进行比较,我们进行了小型精神状态检查;Stroop颜色和单词测试;符号数字模态测试;试制试验,A部分和B部分;以及类别流利性(动物)任务。结果:LASSI-L的七个部分中有五个部分捕捉到了群体差异:主动语义干扰(PSI;P<0.001)、未能从PSI中恢复(P=0.038)、逆向语义干扰(RSI;P=0.013)、延迟回忆(P<0.001),和B1提示的回忆性侵入(P=0.036)。使用错误发现率的结论:LASSI-L是检测preHD患者早期干扰效应的敏感仪器,优于常用的神经心理学测试。LASSI-L可能是涉及preHD患者的临床和研究方案的有用补充。
{"title":"Using the LASSI-L to Detect Robust Interference Effects in Premanifest Huntington Disease.","authors":"Luis A Sierra,&nbsp;Clementina J Ullman,&nbsp;Samuel A Frank,&nbsp;Simon Laganiere","doi":"10.1097/WNN.0000000000000329","DOIUrl":"10.1097/WNN.0000000000000329","url":null,"abstract":"<p><strong>Background: </strong>Diagnosis of manifest Huntington disease (HD) is based primarily on motor symptoms, but premanifest HD (preHD) is often associated with subtle cognitive decline. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) is a validated verbal learning test that can be used to detect early cognitive decline.</p><p><strong>Objective: </strong>To determine the utility of the LASSI-L for detecting early cognitive decline in individuals with preHD and to compare the results of the LASSI-L with those of commonly used neuropsychological tests in HD.</p><p><strong>Method: </strong>We administered the LASSI-L to 13 individuals with preHD and 13 healthy controls matched for age, sex, and education as part of a longitudinal study of disease progression. For comparison purposes, we administered the Mini-Mental State Examination; Stroop Color and Word Test; Symbol Digit Modalities Test; Trail-Making Test, Parts A and B; and category fluency (animals) task.</p><p><strong>Results: </strong>Five of the seven sections on the LASSI-L captured group differences: Proactive Semantic Interference (PSI; P < 0.001), Failure to Recover From PSI ( P = 0.038), Retroactive Semantic Interference (RSI; P = 0.013), Delayed Recall ( P < 0.001), and B1 Cued Recall Intrusions ( P = 0.036). Using a false discovery rate of <0.05, PSI, RSI, and Delayed Recall remained significant.</p><p><strong>Conclusion: </strong>The LASSI-L is a sensitive instrument for detecting early interference effects in individuals with preHD that outperforms commonly used neuropsychological tests. The LASSI-L could be a useful addition to clinical and research protocols involving individuals with preHD.</p>","PeriodicalId":50671,"journal":{"name":"Cognitive and Behavioral Neurology","volume":"36 2","pages":"100-107"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9953067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Memory and Consciousness-Usually in Tandem but Sometimes Apart. 记忆和意识通常是串联的,但有时是分开的。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-06-01 DOI: 10.1097/WNN.0000000000000337
Christopher R Madan

Episodic memory, the ability to remember specific events from one's personal past, has been the subject of research for several decades, with a particular emphasis on its relationship with consciousness. In the December 2022 issue of Cognitive and Behavioral Neurology , Budson, Richman, and Kensinger shed new light on this complex topic with a comprehensive exploration of consciousness. In this commentary, I present three propositions about the relationship between episodic memory and consciousness: (1) Episodic memory is usually associated with conscious retrieval; (2) it is possible to have consciousness without episodic memory; and (3) episodic memory can be accessed without conscious retrieval. Drawing from studies conducted with nonhuman animals, I provide evidence to support each of these propositions and discuss how they relate to the theory presented by Budson et al (2000). Although some of my propositions differ from their views, their work has been valuable in stimulating ongoing discussions to advance our understanding of memory.

情节记忆,即记忆个人过去特定事件的能力,几十年来一直是研究的主题,特别强调其与意识的关系。在2022年12月出版的《认知与行为神经病学》杂志上,布德森、里奇曼和肯辛格通过对意识的全面探索,对这一复杂话题进行了新的探讨。在这篇评论中,我提出了关于情节记忆和意识之间关系的三个命题:(1)情节记忆通常与意识检索有关;(2) 在没有情节记忆的情况下有意识是可能的;以及(3)情景记忆可以在没有意识检索的情况下被访问。根据对非人类动物进行的研究,我提供了证据来支持这些命题,并讨论了它们与Budson等人(2000)提出的理论之间的关系。尽管我的一些主张与他们的观点不同,但他们的工作在激发正在进行的讨论以促进我们对记忆的理解方面很有价值。
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引用次数: 0
Pilot Study of the Effects of Paced Breathing on Measures of Convergent and Divergent Thinking. 有节奏的呼吸对聚合和发散思维的影响的初步研究。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-03-01 DOI: 10.1097/WNN.0000000000000334
McKenzie B Wallace, Amy N Costa, Bradley J Ferguson, Megan A Carey, Chloe Rzeppa, Briana M Kille, David R Drysdale, Briann E Sutton, Brianne H Shuler, Ryan P Johnson, Elizabeth P Kwenda, Jamie Hadley, Whitney Snyders, David Q Beversdorf

Background: The ability of the autonomic nervous system's stress response to impair aspects of cognitive flexibility is known. However, the ability to modulate the sympathetic response and improve these cognitive impairments via nonpharmacological intervention, such as paced breathing (PB), requires further investigation.

Objective: To better elucidate the effects of PB on cognition.

Method: We employed a PB protocol in a total of 52 healthy men and women and measured performance on convergent and divergent cognitive tasks, perceived stress, and physiological measures (eg, blood pressure, heart rate). Participants attended two experimental sessions consisting of either PB or normal breathing followed by cognitive assessments including convergent (compound remote associate, anagram) and divergent (alternate use, fluency) tasks. Experiment 2 consisted of more difficult versions of cognitive tasks compared with Experiment 1.

Results: In Experiment 1, PB significantly reduced the female participants' systolic and diastolic blood pressure immediately after the breathing protocol without affecting their cognition. In Experiment 2, PB significantly reduced perceived stress immediately after the breathing protocol, regardless of sex. There was no effect on cognition in Experiment 2, but a correlation was observed between perceived stress change and anagram number solved change.

Conclusion: While PB modulates sympathetic activity in females, there was a lack of improvement in cognitive flexibility performance. At least for a single trial of PB, cognitive flexibility did not improve.

背景:自主神经系统的应激反应损害认知灵活性的能力是已知的。然而,通过非药物干预(如起搏呼吸(PB))调节交感神经反应和改善这些认知障碍的能力需要进一步研究。目的:更好地阐明PB对认知功能的影响。方法:我们对52名健康男性和女性采用了PB方案,并测量了他们在趋同和发散认知任务、感知压力和生理指标(如血压、心率)方面的表现。参与者参加了两次实验,包括PB或正常呼吸,然后进行认知评估,包括收敛(复合远程联想、变位词)和发散(交替使用、流利性)任务。与实验1相比,实验2由更难的认知任务组成。结果:在实验1中,PB在不影响女性认知的情况下,显著降低了女性参与者在呼吸方案后的收缩压和舒张压。在实验2中,PB显著降低了呼吸方案后立即感知到的压力,无论性别如何。实验2对认知没有影响,但观察到感知压力变化和变位数字解决变化之间存在相关性。结论:虽然PB调节女性的交感神经活动,但认知灵活性表现缺乏改善。至少在PB的单一试验中,认知灵活性没有改善。
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引用次数: 0
Effect of Dopaminergic Therapy on Impulse Control Disorders in Patients With a Prolactinoma. 多巴胺能治疗对泌乳素瘤患者冲动控制障碍的影响。
IF 1.4 4区 医学 Q4 BEHAVIORAL SCIENCES Pub Date : 2023-03-01 DOI: 10.1097/WNN.0000000000000320
Esin Ozdeniz Varan, Hakan Gurvit

Background: Studies have reported an increase in the incidence of impulse control disorders (ICDs) in patient groups treated with dopamine agonists (DAAs), especially in Parkinson disease (PD). However, very few studies have reported on ICDs in individuals with a prolactinoma who were treated with DAAs.

Objective: To see whether a DAA by itself causes ICDs in individuals with a prolactinoma by controlling the susceptibility to impulsivity by excluding individuals with other risk factors for ICDs.

Method: We compared the performance of 31 individuals with a prolactinoma receiving DAA therapy (DAA+) on various behavioral scales and the Iowa gambling task (IGT), a neuropsychological instrument that measures risky decision-making, with the performance of 20 individuals with a prolactinoma who were not on DAA therapy (DAA-) and 30 healthy controls (HC).

Results: There was no significant difference among the groups concerning performance on the Zuckerman Sensation Seeking Scale-V, Minnesota Impulse Disorders Interview, Barratt Impulsiveness Scale-11, or IGT. No correlation was found between the scores on these scales and the duration or dose of DAA in the DAA+ group. The incidence of ICDs was 25.8% in the DAA+ group, 15% in the DAA- group, and 16.7% in the HC. The differences among the groups did not reach statistical significance.

Conclusion: Individuals who are under treatment with low-dose, D 2 -selective DAAs for a prolactinoma do not face an increased risk for ICDs, especially when they are carefully screened for any psychiatric comorbidity that may also display impulsivity.

背景:研究报告称,在使用多巴胺激动剂(DAAs)治疗的患者组中,冲动控制障碍(ICD)的发生率增加,尤其是在帕金森病(PD)中。然而很少有研究报道用DAA治疗的泌乳素瘤患者的ICDs。目的:通过排除有ICDs其他危险因素的患者来控制冲动易感性,从而了解DAA本身是否会导致泌乳素瘤的ICDs。方法:我们比较了31名接受DAA治疗(DAA+)的泌乳素腺瘤患者的表现在各种行为量表和爱荷华赌博任务(IGT)(一种衡量风险决策的神经心理学工具)上,对20名未接受DAA治疗的泌乳素瘤患者和30名健康对照组(HC)的表现进行了比较,明尼苏达州冲动障碍访谈,Barratt冲动量表-11,或IGT。在DAA+组中,这些量表上的分数与DAA的持续时间或剂量之间没有发现相关性。ICDs的发生率在DAA+组为25.8%,在DAA-组为15%,在HC组为16.7%。各组之间的差异没有达到统计学意义。结论:接受低剂量、D2选择性DAAs治疗泌乳素瘤的个体不会面临增加的ICDs风险,尤其是当他们仔细筛查任何可能表现出冲动的精神共病时。
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引用次数: 1
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Cognitive and Behavioral Neurology
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