Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6479
Afifa Naaz, Ghulam Nabi Wani, Wajeeha Begum, Shavana Fathima
Background: Trachyspermum ammi Linn., commonly known as ajwain, is a widely recognized spice and medicinal plant originating from Egypt but cultivated across regions such as Iraq, Iran, Afghanistan, Pakistan, and India. Belonging to the Apiaceae family, this species offers diverse pharmacological benefits due to its rich chemical constituents. Objectives: This review aims to summarize the traditional and contemporary applications of Trachyspermum ammi, focusing on its ethnobotanical description, chemical composition, and pharmacological aspects. Methodology: The literature search encompassed scientific databases and publications covering the historical usage, chemical profiling, and biological activities of Trachyspermum ammi. Results: Trachyspermum ammi exhibits a variety of pharmacological activities, including antifungal, antioxidant, antimicrobial, antinociceptive, antispasmodic, carminative, diuretic, aphrodisiac, and anthelmintic properties. Traditionally, it has been employed to treat conditions such as flatulence, atonic dyspepsia, diarrhea, abdominal tumors, abdominal pain, piles, bronchial issues, lack of appetite, galactogogue, asthma, and amenorrhea as it possesses properties of Muhallil, Mudirr-i-Bawl-o-Hayd, Dafa e Tafun, Jali, Habis etc. Modern research supports these claims while also revealing its potential in treating kidney stones, abortion, and aflatoxin detoxification. Conclusion: Trachyspermum ammi holds great promise as a natural resource for novel therapies, owing to its extensive array of bioactive components and established pharmacological effects. Further investigation into its mechanisms of action and optimization of extraction techniques could lead to more efficient utilization of this valuable medicinal plant. Keywords: Ajwain, Nankhawah, Trachyspermum Ammi Linn, Mudirr-i-Bawl-o-Hayd, Hazim, Thymol, Appetizer.
{"title":"Therapeutic potential of Nankhawah/Ajwain (Tracyspermum ammi Linn): A comprehensive review article","authors":"Afifa Naaz, Ghulam Nabi Wani, Wajeeha Begum, Shavana Fathima","doi":"10.22270/jddt.v14i3.6479","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6479","url":null,"abstract":"Background: Trachyspermum ammi Linn., commonly known as ajwain, is a widely recognized spice and medicinal plant originating from Egypt but cultivated across regions such as Iraq, Iran, Afghanistan, Pakistan, and India. Belonging to the Apiaceae family, this species offers diverse pharmacological benefits due to its rich chemical constituents. \u0000Objectives: This review aims to summarize the traditional and contemporary applications of Trachyspermum ammi, focusing on its ethnobotanical description, chemical composition, and pharmacological aspects. \u0000Methodology: The literature search encompassed scientific databases and publications covering the historical usage, chemical profiling, and biological activities of Trachyspermum ammi. \u0000Results: Trachyspermum ammi exhibits a variety of pharmacological activities, including antifungal, antioxidant, antimicrobial, antinociceptive, antispasmodic, carminative, diuretic, aphrodisiac, and anthelmintic properties. Traditionally, it has been employed to treat conditions such as flatulence, atonic dyspepsia, diarrhea, abdominal tumors, abdominal pain, piles, bronchial issues, lack of appetite, galactogogue, asthma, and amenorrhea as it possesses properties of Muhallil, Mudirr-i-Bawl-o-Hayd, Dafa e Tafun, Jali, Habis etc. Modern research supports these claims while also revealing its potential in treating kidney stones, abortion, and aflatoxin detoxification. \u0000Conclusion: Trachyspermum ammi holds great promise as a natural resource for novel therapies, owing to its extensive array of bioactive components and established pharmacological effects. Further investigation into its mechanisms of action and optimization of extraction techniques could lead to more efficient utilization of this valuable medicinal plant. \u0000Keywords: Ajwain, Nankhawah, Trachyspermum Ammi Linn, Mudirr-i-Bawl-o-Hayd, Hazim, Thymol, Appetizer.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"66 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6477
Palak Palak, Ritu Rani, Rajesh Kumar, A. Singh, A. Singh
The objective of the present study was to formulate topical Niosomal gel loaded with combination of Tretinoin, also known as all-trans retinoic acid (ATRA), and Clindamycin for the beneficial of acne patients, to provide sustained release effects, to prevent their side effects. Purpose of this study was to develop a stable formulation that allows progressive follicle penetration and increased efficacy. Niosomes was prepared by ether injection method. Preformulation studies such as melting point, FTIR spectroscopy, UV spectroscopy, solubility, partition coefficient (log P) were performed for both drugs. In preformulation study, FTIR spectrum reveals that drugs were in pure state. Combination of Tretinoin and clindamycin reveal better therapeutic efficacy and patient compliance as compared to individual agent. From the research findings, it can be concluded that Tretinoin as well as Clindamycin hydrochloride was successfully integrated into niosomal gel by ether injection method for topical application in the treatment of acne. Keywords: Niosomes; Tretinoin (ALL TRANS RETINOIC ACID); Clindamycin; Carbopol gel; Acne; Ether injection method.
{"title":"Formulation and Evaluation of Niosomal gel using Tretinoin and Clindamycin combination","authors":"Palak Palak, Ritu Rani, Rajesh Kumar, A. Singh, A. Singh","doi":"10.22270/jddt.v14i3.6477","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6477","url":null,"abstract":"The objective of the present study was to formulate topical Niosomal gel loaded with combination of Tretinoin, also known as all-trans retinoic acid (ATRA), and Clindamycin for the beneficial of acne patients, to provide sustained release effects, to prevent their side effects. Purpose of this study was to develop a stable formulation that allows progressive follicle penetration and increased efficacy. Niosomes was prepared by ether injection method. Preformulation studies such as melting point, FTIR spectroscopy, UV spectroscopy, solubility, partition coefficient (log P) were performed for both drugs. In preformulation study, FTIR spectrum reveals that drugs were in pure state. Combination of Tretinoin and clindamycin reveal better therapeutic efficacy and patient compliance as compared to individual agent. From the research findings, it can be concluded that Tretinoin as well as Clindamycin hydrochloride was successfully integrated into niosomal gel by ether injection method for topical application in the treatment of acne. \u0000Keywords: Niosomes; Tretinoin (ALL TRANS RETINOIC ACID); Clindamycin; Carbopol gel; Acne; Ether injection method.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"17 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6457
Agustina Ayu, Puput Fiohana, Djazuly Chalidyanto, N. Damayanti
The basic principle of health care in health institutions that continues to require quality improvement is patient safety. This study aims to analyze the relationship between patient safety culture and the level of knowledge of health workers with compliance with patient identification. This research is quantitative analytical with an observational approach. Data was collected on 70 respondents by observing patient identification compliance, patient safety culture questionnaires, and the level of knowledge of health workers regarding patient identification. Data were analyzed using correlation coefficient analysis. The results of the analysis show that there is a significant relationship between patient safety culture and level of knowledge and compliance with patient identification (p = 0.000 < 0.05). The findings of this study provide insight into the importance of patient safety culture and the level of knowledge of health workers in increasing their compliance in carrying out patient identification, especially in hospitals. This study suggests that management and related health workers should actively participate in implementing patient safety programs, especially those involved in patient identification, to achieve optimal patient safety outcomes. Keywords: Patient Safety Culture, Patient Identification, Hospital, Health personnel
{"title":"The Relationship between Patient Safety Culture and The Level of Knowledge of Health Personnel with Compliance in Patient Identification Implementation in Hospital","authors":"Agustina Ayu, Puput Fiohana, Djazuly Chalidyanto, N. Damayanti","doi":"10.22270/jddt.v14i3.6457","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6457","url":null,"abstract":"The basic principle of health care in health institutions that continues to require quality improvement is patient safety. This study aims to analyze the relationship between patient safety culture and the level of knowledge of health workers with compliance with patient identification. This research is quantitative analytical with an observational approach. Data was collected on 70 respondents by observing patient identification compliance, patient safety culture questionnaires, and the level of knowledge of health workers regarding patient identification. Data were analyzed using correlation coefficient analysis. The results of the analysis show that there is a significant relationship between patient safety culture and level of knowledge and compliance with patient identification (p = 0.000 < 0.05). The findings of this study provide insight into the importance of patient safety culture and the level of knowledge of health workers in increasing their compliance in carrying out patient identification, especially in hospitals. This study suggests that management and related health workers should actively participate in implementing patient safety programs, especially those involved in patient identification, to achieve optimal patient safety outcomes. \u0000Keywords: Patient Safety Culture, Patient Identification, Hospital, Health personnel","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"15 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6441
O. S. Egbule, Emmanuel Morka, Patricia Konye Omenogor
This study aimed to assess the prevalence of Staphylococcus aureus and Enterococcus sp. among pregnant women who visit the General Hospital in Delta Central Senatorial District, Nigeria. Samples were collected from the vaginal and rectum areas of pregnant women attending the General Hospitals of Abraka, Oghara, Udu, Ughelli North and Ughelli South. Bacteriological and biochemical analyses were conducted to isolate, characterize, and identify the bacteria. Two types of bacteria were found; Enterococcus sp. and Staphylococcus sp. The study result showed that Staphylococcus aureus (13.7%) was more prevalent than other isolates and was found in samples obtained from Udu General Hospital. In comparison, Ughelli South General Hospital had the lowest prevalence for S. aureus (7.9%). Samples from Oghara General Hospital had the highest prevalence for Enterococcus sp. (3.7%) while the lowest prevalence for Enterococcus sp. (1.1%) was obtained from Ughelli South General Hospital. S. aureus (51.6%) was found to be the most prevalent bacterium, while Enterococcus sp. (11.1%) was the least prevalent. The bacterial load from the vaginal swab samples was higher than that of rectum swab samples, which suggests that pregnant women attending these hospitals may have infections. The total bacterial count among pregnant women was highest in samples obtained from Udu General Hospital (5.4±0.5), followed by Abraka (5.0±0.6), Oghara (4.8±0.2), and Ughelli North (4.5±0.15), and while the least count was recorded from samples obtained from Ughelli South General Hospital (3.0±0.2). This study helps manage and plan future medical treatments. Pregnant women should be screened early in their pregnancies, between the 12th and 16th weeks, which is the second trimester, and treated appropriately to avoid complications that arise from untreated infections. Keywords: Prevalence, vaginal, pregnancy, women, infection
本研究旨在评估在尼日利亚三角洲中央参议院区综合医院就诊的孕妇中金黄色葡萄球菌和肠球菌的流行情况。研究人员从阿布拉卡、奥加拉、乌杜、乌盖里北部和乌盖里南部综合医院就诊孕妇的阴道和直肠部位采集样本。通过细菌学和生化分析，对细菌进行了分离、定性和鉴定。研究结果表明，金黄色葡萄球菌（13.7%）比其他分离菌更为普遍，在乌杜综合医院的样本中也有发现。相比之下，Ughelli South 综合医院的金黄色葡萄球菌感染率最低（7.9%）。来自 Oghara 综合医院的样本中肠球菌的感染率最高（3.7%），而来自 Ughelli South 综合医院的样本中肠球菌的感染率最低（1.1%）。金黄色葡萄球菌（51.6%）是感染率最高的细菌，而肠球菌（11.1%）则是感染率最低的细菌。阴道拭子样本的细菌量高于直肠拭子样本，这表明在这些医院就诊的孕妇可能受到感染。孕妇细菌总数最高的样本来自 Udu 综合医院（5.4±0.5），其次是 Abraka（5.0±0.6）、Oghara（4.8±0.2）和 Ughelli North（4.5±0.15），而最少的样本来自 Ughelli South 综合医院（3.0±0.2）。这项研究有助于管理和规划未来的医疗。孕妇应在怀孕早期，即第12周至第16周，也就是怀孕的后三个月进行筛查，并进行适当治疗，以避免因未治疗感染而引发并发症。 关键词流行、阴道、妊娠、妇女、感染
{"title":"Prevalence of Staphylococcus aureus and Enterococcus sp. Among Pregnant Women Attending General Hospitals in Delta Central Senatorial District, Nigeria","authors":"O. S. Egbule, Emmanuel Morka, Patricia Konye Omenogor","doi":"10.22270/jddt.v14i3.6441","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6441","url":null,"abstract":"This study aimed to assess the prevalence of Staphylococcus aureus and Enterococcus sp. among pregnant women who visit the General Hospital in Delta Central Senatorial District, Nigeria. Samples were collected from the vaginal and rectum areas of pregnant women attending the General Hospitals of Abraka, Oghara, Udu, Ughelli North and Ughelli South. Bacteriological and biochemical analyses were conducted to isolate, characterize, and identify the bacteria. Two types of bacteria were found; Enterococcus sp. and Staphylococcus sp. The study result showed that Staphylococcus aureus (13.7%) was more prevalent than other isolates and was found in samples obtained from Udu General Hospital. In comparison, Ughelli South General Hospital had the lowest prevalence for S. aureus (7.9%). Samples from Oghara General Hospital had the highest prevalence for Enterococcus sp. (3.7%) while the lowest prevalence for Enterococcus sp. (1.1%) was obtained from Ughelli South General Hospital. S. aureus (51.6%) was found to be the most prevalent bacterium, while Enterococcus sp. (11.1%) was the least prevalent. The bacterial load from the vaginal swab samples was higher than that of rectum swab samples, which suggests that pregnant women attending these hospitals may have infections. The total bacterial count among pregnant women was highest in samples obtained from Udu General Hospital (5.4±0.5), followed by Abraka (5.0±0.6), Oghara (4.8±0.2), and Ughelli North (4.5±0.15), and while the least count was recorded from samples obtained from Ughelli South General Hospital (3.0±0.2). This study helps manage and plan future medical treatments. Pregnant women should be screened early in their pregnancies, between the 12th and 16th weeks, which is the second trimester, and treated appropriately to avoid complications that arise from untreated infections. \u0000Keywords: Prevalence, vaginal, pregnancy, women, infection","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"123 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6440
Iram Ateeq, K. Firdose
Background and aim: Tamarix gallica L. is commonly known as “Jhau”. These deciduous, herbaceous, twiggy shrub or small tree reaching up to about 5 meters high and mainly found in the salty regions and is found between interdunal areas of the desert. It has enormous potential and having a broad spectrum of activity on a variety of illnesses such as leukoderma, eye diseases, teeth disorder, any type of hemorrhage, spleen disorders etc. This review aims to compile maximum information available, regarding its various traditional uses, pharmacognosy, phytochemical constituents and pharmacological activities to enrich our knowledge about this plant. Materials and methods: A manual literature survey of classical Unani texts such as Khazā’in al-Adwiya, Tanqīh-al-Mufradāt, Bustān-al- Mufradāt, Muḥīṭ-i-A‘ẓam and online literature survey from Pubmed, Google scholar, Cochrane library, science direct was conducted to collect the information available on the plant Tamarix gallica. Result and discussion: The findings of the literature survey on the basis of previous phytochemical analyses of this plant revealed the presence of a number of components, some of which are tannin, tannic acid, tamarixin, significant amount of phenolic and flavonoid content, antioxidants like carotenoids and essential oils which are extracted from various parts of the plants. Its reported pharmacological activities include anti-inflammatory, antinociceptive, anti-proliferative, antibacterial, antioxidant, anti-hyperlipidemic, antidiarrheal, cytotoxic activity and hepatoprotective activities. Keywords: Tamarix gallica, phytochemical analyses, tannin, antioxidant, pharmacological activities, anti-inflammatory, antinociceptive, antiproliferative, antibacterial.
{"title":"A Comprehensive Review of Tamaric gallica Linn.: A Herbal Haemostat with special reference in Unani Medicine","authors":"Iram Ateeq, K. Firdose","doi":"10.22270/jddt.v14i3.6440","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6440","url":null,"abstract":"Background and aim: Tamarix gallica L. is commonly known as “Jhau”. These deciduous, herbaceous, twiggy shrub or small tree reaching up to about 5 meters high and mainly found in the salty regions and is found between interdunal areas of the desert. It has enormous potential and having a broad spectrum of activity on a variety of illnesses such as leukoderma, eye diseases, teeth disorder, any type of hemorrhage, spleen disorders etc. This review aims to compile maximum information available, regarding its various traditional uses, pharmacognosy, phytochemical constituents and pharmacological activities to enrich our knowledge about this plant. \u0000Materials and methods: A manual literature survey of classical Unani texts such as Khazā’in al-Adwiya, Tanqīh-al-Mufradāt, Bustān-al- Mufradāt, Muḥīṭ-i-A‘ẓam and online literature survey from Pubmed, Google scholar, Cochrane library, science direct was conducted to collect the information available on the plant Tamarix gallica. \u0000Result and discussion: The findings of the literature survey on the basis of previous phytochemical analyses of this plant revealed the presence of a number of components, some of which are tannin, tannic acid, tamarixin, significant amount of phenolic and flavonoid content, antioxidants like carotenoids and essential oils which are extracted from various parts of the plants. Its reported pharmacological activities include anti-inflammatory, antinociceptive, anti-proliferative, antibacterial, antioxidant, anti-hyperlipidemic, antidiarrheal, cytotoxic activity and hepatoprotective activities. \u0000Keywords: Tamarix gallica, phytochemical analyses, tannin, antioxidant, pharmacological activities, anti-inflammatory, antinociceptive, antiproliferative, antibacterial.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"10 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6451
María del Rocío Guillén-Núñez, Á. M. Juárez-Lemus, B. Hernández-Porras, Daniela Hernández-Rodríguez
Pain is one of the 10 leading causes of medical consultation worldwide and is the alarm symptom of the organism in situations that threaten its integrity, however, when it becomes chronic, it loses its protective capacity and becomes, in many cases, the disease itself. According to the International Association for the Study of Pain (IASP) pain is classified as nociceptive, neuropathic and nociplastic. Mixed pain has been described years ago due to the coexistence of different types of pain. We can conclude that we do not have a screening tool and/or treatment algorithm for mixed pain, so it is preferable that pain management begins with a rigorous assessment, using the latest available tools, followed by individualized evidence-based treatment with multimodal therapy when appropriate. Keywords: nociceptive pain, neuropathic pain, mixed pain.
{"title":"Current Perspective in Mixed Pain","authors":"María del Rocío Guillén-Núñez, Á. M. Juárez-Lemus, B. Hernández-Porras, Daniela Hernández-Rodríguez","doi":"10.22270/jddt.v14i3.6451","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6451","url":null,"abstract":"Pain is one of the 10 leading causes of medical consultation worldwide and is the alarm symptom of the organism in situations that threaten its integrity, however, when it becomes chronic, it loses its protective capacity and becomes, in many cases, the disease itself. \u0000According to the International Association for the Study of Pain (IASP) pain is classified as nociceptive, neuropathic and nociplastic. Mixed pain has been described years ago due to the coexistence of different types of pain. \u0000We can conclude that we do not have a screening tool and/or treatment algorithm for mixed pain, so it is preferable that pain management begins with a rigorous assessment, using the latest available tools, followed by individualized evidence-based treatment with multimodal therapy when appropriate. \u0000Keywords: nociceptive pain, neuropathic pain, mixed pain.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"26 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6488
Akash Akash, Ritu Rani, A. Singh, A. Singh
Anxiety affects both humans and animals in profound ways, and understanding its psychological and biological components is essential to the development of anxiolytic medications. Animal models are utilized as simulations to explain emotional activities and as screening tools in anxiety research. Rats are the animal model used most often; mice, a more genetically flexible mammal, do less well in animal models. Behavioral investigations need careful consideration of changeable characteristics related to handling, climate, or models. To help us better understand the neurobiological elements of anxiety, the most recent experimental anxiety models such as the elevated plus maze apparatus, light-dark model, open field apparatus, and hole board apparatus are being examined. Psychopharmacological disorders affect one in seven Indians; nevertheless, adverse effects include weight gain, cramping in the muscles, dysphoria, upset stomach, blurred vision, and issues with blood tests may occur. In order to improve our knowledge of the animal models used to determine the anxiolytic action in mice, we will talk about pertinent animal models that have been established in this article. Keywords: Anxiolytic activity, Anxiety, Elevated zero maze, Plus maze, Elevated T maze, light and dark box model and Mirrored chamber, Animal models
{"title":"Animals Use to Find Anxiolytic Activity: An Updated Review with Advantage of Each Model","authors":"Akash Akash, Ritu Rani, A. Singh, A. Singh","doi":"10.22270/jddt.v14i3.6488","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6488","url":null,"abstract":"Anxiety affects both humans and animals in profound ways, and understanding its psychological and biological components is essential to the development of anxiolytic medications. Animal models are utilized as simulations to explain emotional activities and as screening tools in anxiety research. Rats are the animal model used most often; mice, a more genetically flexible mammal, do less well in animal models. Behavioral investigations need careful consideration of changeable characteristics related to handling, climate, or models. To help us better understand the neurobiological elements of anxiety, the most recent experimental anxiety models such as the elevated plus maze apparatus, light-dark model, open field apparatus, and hole board apparatus are being examined. Psychopharmacological disorders affect one in seven Indians; nevertheless, adverse effects include weight gain, cramping in the muscles, dysphoria, upset stomach, blurred vision, and issues with blood tests may occur. In order to improve our knowledge of the animal models used to determine the anxiolytic action in mice, we will talk about pertinent animal models that have been established in this article. \u0000Keywords: Anxiolytic activity, Anxiety, Elevated zero maze, Plus maze, Elevated T maze, light and dark box model and Mirrored chamber, Animal models","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"72 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6475
Oma Shanker, Arsh Chanana, Pooja Gupta, Aditya Narayan, Yukta R. Kulkarni, Akhilesh Patel, Ujwal Havelikar, Bhabesh Mahato, Ravindra Pal Singh, H. Chawra, Anurag Mishra
Niosomes are artificially manufactured vesicles made of Cholesterol and Non-ionic surfactant. Their capacity to encapsulate a broad variety of pharmaceuticals and shield them from deterioration has piqued interest in drug delivery. Niosomes have demonstrated a possible use in the administration of anti-tuberculosis medications. Worldwide, tuberculosis is a serious public health concern. Even with advances in science and technology, tuberculosis remains a persistent problem.Niosomes can encapsulate anti-TB drugs, protecting them from enzymatic degradation and allowing for sustained release. Research in this field is on-going, with scientists working on optimizing niosomal formulations for tuberculosis treatment. It's important to consult current scientific literature for the latest advancements. Some anti-tubercular drugs face challenges in terms of absorption and bioavailability. Niosomal delivery systems can help address these issues. While niosomal drug delivery systems show promise, it's crucial to note that they are still an area of active research and specific formulations and protocols may vary. Patients should always consult with their healthcare providers for the most appropriate and up-to-date treatment options for tuberculosis. Niosomes can encapsulate both hydrophilic and lipophilic drugs, offering advantages such as increased drug stability, prolonged circulation time, controlled release, and targeted delivery. They have applications in various fields including pharmaceuticals, cosmetics, and agriculture. Keywords: Tuberculosis, Niosomes, Drug delivery system
{"title":"Niosomal Drug Delivery System used in Tuberculosis","authors":"Oma Shanker, Arsh Chanana, Pooja Gupta, Aditya Narayan, Yukta R. Kulkarni, Akhilesh Patel, Ujwal Havelikar, Bhabesh Mahato, Ravindra Pal Singh, H. Chawra, Anurag Mishra","doi":"10.22270/jddt.v14i3.6475","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6475","url":null,"abstract":"Niosomes are artificially manufactured vesicles made of Cholesterol and Non-ionic surfactant. Their capacity to encapsulate a broad variety of pharmaceuticals and shield them from deterioration has piqued interest in drug delivery. Niosomes have demonstrated a possible use in the administration of anti-tuberculosis medications. Worldwide, tuberculosis is a serious public health concern. Even with advances in science and technology, tuberculosis remains a persistent problem.Niosomes can encapsulate anti-TB drugs, protecting them from enzymatic degradation and allowing for sustained release. Research in this field is on-going, with scientists working on optimizing niosomal formulations for tuberculosis treatment. It's important to consult current scientific literature for the latest advancements. Some anti-tubercular drugs face challenges in terms of absorption and bioavailability. Niosomal delivery systems can help address these issues. While niosomal drug delivery systems show promise, it's crucial to note that they are still an area of active research and specific formulations and protocols may vary. Patients should always consult with their healthcare providers for the most appropriate and up-to-date treatment options for tuberculosis. Niosomes can encapsulate both hydrophilic and lipophilic drugs, offering advantages such as increased drug stability, prolonged circulation time, controlled release, and targeted delivery. They have applications in various fields including pharmaceuticals, cosmetics, and agriculture. \u0000Keywords: Tuberculosis, Niosomes, Drug delivery system","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"27 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6467
I. A. Gaidashev, Yuliana Gennadievna Nikolaeva, A. V. Syroeshkin
The purposes of pharmaceutical biotechnology and quality control of probiotics containing lyophilized bacterial preparations, as well as the purpose of ensuring biological safety, require methods for rapid determination of the viability of dormant forms. This paper describes an approach to determining the viability of dry powdered substances. Lyophilized powder of Kalanchoe daigermontiana, dry dormant eggs of Artemia salina, and dry powder of Lycopodium sp. spores were proposed as model objects. Suspensions of virus-like particles (VLPs) to SARS-CoV-2 were proposed as a cell-free reference material. The following methods of elemental analysis were used in the study: X-ray fluorescence spectroscopy (XRF) on an energy-dispersive device, atomic absorption spectroscopy with electrothermal atomization, and Zeeman background correction (GZ-AAS). The free water content was determined by NMR spin echo. A new method was also used for recording the kinetics of changes in broadband radio emission in the centimeter and millimeter wavelength ranges, with a measurement duration of up to 20 minutes. Live and inactivated powdered preparations of K. daigermontiana and A. salina were prepared and characterized by elemental composition, water content, and spin-spin relaxation time (T2). For these live and inactivated preparations, it was determined that the flux density of intrinsic thermal radio emission decreases by an order of magnitude with the loss of viability. In the future, the results obtained will allow for a rapid test of the viability of lyophilized therapeutics (from medicinal plants to bacterial mixtures that stabilize the intestinal microflora). Keywords: millimeter emission, X-ray fluorescence analysis, NMR spin echo, nanoparticles, powdered substances, medicinal plant raw materials
为了实现制药生物技术和含有冻干细菌制剂的益生菌质量控制的目的，以及确保生物安全的目的，需要有快速测定休眠形式活力的方法。本文介绍了一种测定干粉物质活力的方法。本文提出了冻干的 Kalanchoe daigermontiana 粉末、干燥的盐蒿休眠卵和干燥的 Lycopodium sp.建议将 SARS-CoV-2 病毒样颗粒（VLPs）悬浮液作为无细胞参考材料。研究中使用了以下元素分析方法：能量色散装置上的 X 射线荧光光谱法（XRF）、电热原子化原子吸收光谱法和泽曼背景校正法（GZ-AAS）。自由水含量是通过核磁共振自旋回波测定的。还使用了一种新方法来记录厘米和毫米波长范围内宽带无线电发射的动力学变化，测量持续时间长达 20 分钟。制备了 K. daigermontiana 和 A. salina 的活体和灭活粉末制剂，并通过元素组成、含水量和自旋-自旋弛豫时间（T2）对其进行了表征。对于这些活体和失活制剂，已确定其内在热辐射的通量密度会随着活力的丧失而降低一个数量级。未来，所获得的结果将有助于快速检测冻干疗法（从药用植物到稳定肠道微生物菌群的细菌混合物）的活力。关键词：毫米波发射、X 射线荧光分析、核磁共振自旋回波、纳米颗粒、粉末状物质、药用植物原料
{"title":"Development of a technique for determining the viability of dormant organisms in powdered substances","authors":"I. A. Gaidashev, Yuliana Gennadievna Nikolaeva, A. V. Syroeshkin","doi":"10.22270/jddt.v14i3.6467","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6467","url":null,"abstract":"The purposes of pharmaceutical biotechnology and quality control of probiotics containing lyophilized bacterial preparations, as well as the purpose of ensuring biological safety, require methods for rapid determination of the viability of dormant forms. This paper describes an approach to determining the viability of dry powdered substances. Lyophilized powder of Kalanchoe daigermontiana, dry dormant eggs of Artemia salina, and dry powder of Lycopodium sp. spores were proposed as model objects. Suspensions of virus-like particles (VLPs) to SARS-CoV-2 were proposed as a cell-free reference material. The following methods of elemental analysis were used in the study: X-ray fluorescence spectroscopy (XRF) on an energy-dispersive device, atomic absorption spectroscopy with electrothermal atomization, and Zeeman background correction (GZ-AAS). The free water content was determined by NMR spin echo. A new method was also used for recording the kinetics of changes in broadband radio emission in the centimeter and millimeter wavelength ranges, with a measurement duration of up to 20 minutes. Live and inactivated powdered preparations of K. daigermontiana and A. salina were prepared and characterized by elemental composition, water content, and spin-spin relaxation time (T2). For these live and inactivated preparations, it was determined that the flux density of intrinsic thermal radio emission decreases by an order of magnitude with the loss of viability. In the future, the results obtained will allow for a rapid test of the viability of lyophilized therapeutics (from medicinal plants to bacterial mixtures that stabilize the intestinal microflora). \u0000Keywords: millimeter emission, X-ray fluorescence analysis, NMR spin echo, nanoparticles, powdered substances, medicinal plant raw materials","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"12 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6447
Josee Amin, Naquibul Islam, T. Rafeeqi
Objectives: The objectives of this study were to observe the Efficacy of unani pharmacopoeial formulation Boozidan (Pyrethrum indicum) for the management of Niqris Muzmin (Chronic gout) and to observe any concomitant and adverse effects of formulation. Methods: This single blind, randomized and standard control clinical study was conducted between April 2021 to October 2021 for a period of 28 days. 60 patients diagnosed with chronic gout were divided into two groups, 30 Test group and 30 Control group. The test group was administered with 5g boozidaan in powder form once daily with water and the patients of control group were given tablet febuxostat 80mg once daily. Patients were followed up and improvements in subjective parameters were assessed weekly at 7th, 14th, 21st, and 29th day. Objective parameters were assessed at the baseline and at 29th day. The data obtained was subjected to statistical analysis. Results: Both the test and control drug were effective in reducing Serum uric acid level, ESR and CRP levels. A significant improvement in subjective and objective parameters was observed in both test and control groups and no adverse effects were observed during and after the study. However, the test drug had superior efficacy in reducing the objective parameters and it was statistically significant (p-value<0.0001). Conclusion: Both Boozidaan and Febuxostat were safe and significantly effective in resolving the symptoms and signs of gouty arthritis and both have significant effect on reducing serum uric acid level. Keywords: Boozidaan, Chronic gout, Niqris, Febuxostat, serum uric acid, unani medicine
{"title":"Clinical study to Evaluate Safety and Efficacy of Boozidaan (Pyrethrum indicum) in the management of Niqris Muzmin (Chronic Gout)","authors":"Josee Amin, Naquibul Islam, T. Rafeeqi","doi":"10.22270/jddt.v14i3.6447","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6447","url":null,"abstract":"Objectives: The objectives of this study were to observe the Efficacy of unani pharmacopoeial formulation Boozidan (Pyrethrum indicum) for the management of Niqris Muzmin (Chronic gout) and to observe any concomitant and adverse effects of formulation. \u0000Methods: This single blind, randomized and standard control clinical study was conducted between April 2021 to October 2021 for a period of 28 days. 60 patients diagnosed with chronic gout were divided into two groups, 30 Test group and 30 Control group. The test group was administered with 5g boozidaan in powder form once daily with water and the patients of control group were given tablet febuxostat 80mg once daily. Patients were followed up and improvements in subjective parameters were assessed weekly at 7th, 14th, 21st, and 29th day. Objective parameters were assessed at the baseline and at 29th day. The data obtained was subjected to statistical analysis. \u0000Results: Both the test and control drug were effective in reducing Serum uric acid level, ESR and CRP levels. A significant improvement in subjective and objective parameters was observed in both test and control groups and no adverse effects were observed during and after the study. \u0000However, the test drug had superior efficacy in reducing the objective parameters and it was statistically significant (p-value<0.0001). \u0000Conclusion: Both Boozidaan and Febuxostat were safe and significantly effective in resolving the symptoms and signs of gouty arthritis and both have significant effect on reducing serum uric acid level. \u0000Keywords: Boozidaan, Chronic gout, Niqris, Febuxostat, serum uric acid, unani medicine","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"12 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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