Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6363
Quang-Ung Le, Duc-Thuan Hoang
Based on our knowledge, experience and field survey in the treatment of gout by complementary/alternative medicine and especially the herb therapy, properties of curing gout of Orthosiphon stamineus Benth are briefly commented and suggest that the future research to insightfully educidate this science opinion is necessary. Keywords: Orthosiphon stamineus, gout, alternative medicine
{"title":"Orthosiphon stamineus Benth, a potential herb in treatment of gout: A mini opinion and call for further research","authors":"Quang-Ung Le, Duc-Thuan Hoang","doi":"10.22270/jddt.v14i2.6363","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6363","url":null,"abstract":"Based on our knowledge, experience and field survey in the treatment of gout by complementary/alternative medicine and especially the herb therapy, properties of curing gout of Orthosiphon stamineus Benth are briefly commented and suggest that the future research to insightfully educidate this science opinion is necessary. \u0000Keywords: Orthosiphon stamineus, gout, alternative medicine","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"28 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6435
Blanca Betsabe Aguilera-Elizalde, María del Rocío Guillén-Núñez, Á. Juárez-Lemus, R. Plancarte-Sánchez, Daniela Hernández-Rodríguez, Oliver Humberto González-Vega
Objective: The purpose of this study was to evaluate the efficacy of subcutaneous morphine for managing pain crises resulting from various causes in cancer patients attended by the Pain Clinic in the immediate care area of the National Cancer Institute in Mexico City. Materials and Methods: This study was analytical, observational, retrospective, and descriptive. The oncology patients treated in the immediate care area for pain crises between August 1, 2020, and July 1, 2023, made up our study population. We documented the management of pain crises for patients who needed subcutaneous morphine treatment. Results: Considering a reduction in Numeric Rating Scale (NRS) score >30% as effective and a reduction <30% as ineffective, 566 patients didn’t require an additional dose of subcutaneous morphine to control the pain crisis; 11 patients reported a decrease of <30%. A total of 24 patients needed a second rescue. Among this group, only 5 responded well to the second morphine rescue; in the remaining 19 patients, the rescue was deemed ineffective if the NRS decreased by at least 30%. Only 5 individuals experienced moderate pain, and only one patient reported severe pain. The variables were compared using the non-parametric Mann-Whitney U test with significance <0.05. Consequently, it may be said that there is a statistically significant difference between the first and subsequent NRS values obtained. Conclusion: For oncology patients treated by the Pain Clinic in the immediate care section of the National Cancer Institute in Mexico City, subcutaneous morphine is beneficial in managing pain crises of different origins. Keywords: Morphine, Subcutaneous Pain crises, Efficacy, Numeric rating scale
{"title":"Effectiveness of subcutaneous morphine in the treatment of pain crises in cancer patients","authors":"Blanca Betsabe Aguilera-Elizalde, María del Rocío Guillén-Núñez, Á. Juárez-Lemus, R. Plancarte-Sánchez, Daniela Hernández-Rodríguez, Oliver Humberto González-Vega","doi":"10.22270/jddt.v14i2.6435","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6435","url":null,"abstract":"Objective: The purpose of this study was to evaluate the efficacy of subcutaneous morphine for managing pain crises resulting from various causes in cancer patients attended by the Pain Clinic in the immediate care area of the National Cancer Institute in Mexico City. \u0000Materials and Methods: This study was analytical, observational, retrospective, and descriptive. The oncology patients treated in the immediate care area for pain crises between August 1, 2020, and July 1, 2023, made up our study population. We documented the management of pain crises for patients who needed subcutaneous morphine treatment. \u0000Results: Considering a reduction in Numeric Rating Scale (NRS) score >30% as effective and a reduction <30% as ineffective, 566 patients didn’t require an additional dose of subcutaneous morphine to control the pain crisis; 11 patients reported a decrease of <30%. A total of 24 patients needed a second rescue. Among this group, only 5 responded well to the second morphine rescue; in the remaining 19 patients, the rescue was deemed ineffective if the NRS decreased by at least 30%. Only 5 individuals experienced moderate pain, and only one patient reported severe pain. The variables were compared using the non-parametric Mann-Whitney U test with significance <0.05. Consequently, it may be said that there is a statistically significant difference between the first and subsequent NRS values obtained. \u0000Conclusion: For oncology patients treated by the Pain Clinic in the immediate care section of the National Cancer Institute in Mexico City, subcutaneous morphine is beneficial in managing pain crises of different origins. \u0000Keywords: Morphine, Subcutaneous Pain crises, Efficacy, Numeric rating scale","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"19 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cushing syndrome (CS) is a condition caused due to high levels of cortisol in which weight gain and fat tissue build-up take place. Generally, patients with Cushing syndrome also suffer from diabetes. A 57-year-old female patient with aggravated cortisol levels. Laboratory investigations of the patient were performed and they showed decreased haemoglobin levels, but increased vitamin B12 levels, and TSH levels. The patient was prescribed a combination of medications to manage anemia, anemia, and diabetes. The patient's medical history included splenomegaly, cholelithiasis, panniculitis, and kidney enlargement. The patient's diabetes was responding well to the treatment and was better after 10 days. Keywords: Cushing syndrome, Diabetes mellitus, corticosteroid.
{"title":"A Case Report on Iatrogenic Cushing Syndrome with Diabetes Mellitus","authors":"Aashutosh Sinwal, Aman Kushwaha, Gyan Ranjan, Ratana Ram, Kalpana Upadhayay, Mukesh Choudhary, Mudit Bhardwaj","doi":"10.22270/jddt.v14i2.6421","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6421","url":null,"abstract":"Cushing syndrome (CS) is a condition caused due to high levels of cortisol in which weight gain and fat tissue build-up take place. Generally, patients with Cushing syndrome also suffer from diabetes. A 57-year-old female patient with aggravated cortisol levels. Laboratory investigations of the patient were performed and they showed decreased haemoglobin levels, but increased vitamin B12 levels, and TSH levels. The patient was prescribed a combination of medications to manage anemia, anemia, and diabetes. The patient's medical history included splenomegaly, cholelithiasis, panniculitis, and kidney enlargement. The patient's diabetes was responding well to the treatment and was better after 10 days. \u0000Keywords: Cushing syndrome, Diabetes mellitus, corticosteroid.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"27 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139963284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6326
A. Mandal
Many diseases suffer from drug resistance and nucleic acid cargo delivery. To optimize pharmaceutics and to enhance their efficiency of cellular uptake, DNA nanomaterial tetrahedrons, owing to their precise control in size, shape, excellent biocompatibility and cellular permeability, reduced cytotoxicity, good stability, ease synthesis and multiple sites for targeting design, have attracted attention for targeting cargos delivery. Their nanostructural binding efficiency with many cargos depends on their electrostatic attractions among free electrons of phosphate oxygen, sugar and base nitrogen. Self-assembled DNA tetrahedrons (DTs) alone also can regulate cellular processes to some extent, especially, on migration, differentiation, proliferation and autophagy, and their modifications with the attachment of aptamers, peptides, nucleic acids, antibodies, different low-molecular-weight drugs and other components, make them a novel targeted delivery system as effective nanomedicine. This review demonstrates the current progress of DTs towards their synthesis, characterization, biomedical applications, biodistribution, elimination and toxicity as possible nanoparticulated delivery system. Keywords: Diseases; Drug resistance; DNA tetrahedron; nanoparticulated delivery system; Nanomedicine
许多疾病都受到耐药性和核酸货物运输的困扰。为了优化制药和提高细胞摄取效率，DNA 纳米材料四面体因其精确的尺寸和形状控制、优异的生物相容性和细胞渗透性、降低细胞毒性、良好的稳定性、易于合成和多位点靶向设计等特点，在靶向载体递送方面备受关注。它们与许多载体的纳米结构结合效率取决于磷酸氧、糖和碱基氮的自由电子之间的静电吸引力。自组装 DNA 四面体（DTs）本身也能在一定程度上调控细胞过程，尤其是细胞的迁移、分化、增殖和自噬，而其附着的适配体、多肽、核酸、抗体、不同的低分子量药物和其他成分的修饰，使其成为一种新型的靶向递送系统，成为有效的纳米药物。本综述展示了 DTs 在合成、表征、生物医学应用、生物分布、消除和毒性等方面的研究进展。关键词疾病；耐药性；DNA 四面体；纳米颗粒给药系统；纳米药物
{"title":"DNA tetrahedron as nanoparticulated delivery system in combating diseases","authors":"A. Mandal","doi":"10.22270/jddt.v14i2.6326","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6326","url":null,"abstract":"Many diseases suffer from drug resistance and nucleic acid cargo delivery. To optimize pharmaceutics and to enhance their efficiency of cellular uptake, DNA nanomaterial tetrahedrons, owing to their precise control in size, shape, excellent biocompatibility and cellular permeability, reduced cytotoxicity, good stability, ease synthesis and multiple sites for targeting design, have attracted attention for targeting cargos delivery. Their nanostructural binding efficiency with many cargos depends on their electrostatic attractions among free electrons of phosphate oxygen, sugar and base nitrogen. Self-assembled DNA tetrahedrons (DTs) alone also can regulate cellular processes to some extent, especially, on migration, differentiation, proliferation and autophagy, and their modifications with the attachment of aptamers, peptides, nucleic acids, antibodies, different low-molecular-weight drugs and other components, make them a novel targeted delivery system as effective nanomedicine. This review demonstrates the current progress of DTs towards their synthesis, characterization, biomedical applications, biodistribution, elimination and toxicity as possible nanoparticulated delivery system. \u0000Keywords: Diseases; Drug resistance; DNA tetrahedron; nanoparticulated delivery system; Nanomedicine","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"24 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6399
Ahmadu Saleh, King Akpofure Nelson Esievo
Introduction: The cholesterol hypothesis had been kept alive for decades by reviewers who used statistics that excluded the results from unsuccessful trials and ignored numerous contradictory observations. High dietary cholesterol intake had been associated with development of cardiovascular diseases (CVD) and mortality, for over several decades, without a direct link between the CVD and high serum cholesterol level. Hence, people avoided healthy cholesterol-rich diets due to the fear of developing CVD. The relationship between elevated plasma cholesterol and CVD and criteria for appropriate methods for screening patients with elevated cholesterol had remained a source of medical debates. Lack of decrease in overall mortality rates in patients without clinical coronary disease in whom aggressive lowering of cholesterol was achieved might have contributed to the lack of consensus on this most important issue. Methodology: With information derived from search engines, such as Elsevier, Springer, PubMed, Science Direct, Medline, Google Scholar and a library search for articles published in peer-reviewed journals. Results: Several research results showed that association between total serum cholesterol, its components and CVD is weak, absent or inverse implying that consuming healthy high cholesterol diets may not be harmful to health. Conclusion: This review provides evidence contrasting the links between elevated plasma cholesterol and CVD, and demonstrated that elevated cholesterol concentrations, rather, improve quality of life and life expectancy. In addition, most prevalent methods for cholesterol quantification in biological samples and foods, utilizing new technologies, such as Ambient Ionization Mass Spectrometry are summarized, along with other components of cholesterol. Keywords: Cholesterol, CVD, Quantification
{"title":"Contrasting Evidences Between High Cholesterol Levels and The Risk of Cardiovascular Disease: A Review","authors":"Ahmadu Saleh, King Akpofure Nelson Esievo","doi":"10.22270/jddt.v14i2.6399","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6399","url":null,"abstract":"Introduction: The cholesterol hypothesis had been kept alive for decades by reviewers who used statistics that excluded the results from unsuccessful trials and ignored numerous contradictory observations. High dietary cholesterol intake had been associated with development of cardiovascular diseases (CVD) and mortality, for over several decades, without a direct link between the CVD and high serum cholesterol level. Hence, people avoided healthy cholesterol-rich diets due to the fear of developing CVD. The relationship between elevated plasma cholesterol and CVD and criteria for appropriate methods for screening patients with elevated cholesterol had remained a source of medical debates. Lack of decrease in overall mortality rates in patients without clinical coronary disease in whom aggressive lowering of cholesterol was achieved might have contributed to the lack of consensus on this most important issue. \u0000Methodology: With information derived from search engines, such as Elsevier, Springer, PubMed, Science Direct, Medline, Google Scholar and a library search for articles published in peer-reviewed journals. \u0000Results: Several research results showed that association between total serum cholesterol, its components and CVD is weak, absent or inverse implying that consuming healthy high cholesterol diets may not be harmful to health. \u0000Conclusion: This review provides evidence contrasting the links between elevated plasma cholesterol and CVD, and demonstrated that elevated cholesterol concentrations, rather, improve quality of life and life expectancy. In addition, most prevalent methods for cholesterol quantification in biological samples and foods, utilizing new technologies, such as Ambient Ionization Mass Spectrometry are summarized, along with other components of cholesterol. \u0000Keywords: Cholesterol, CVD, Quantification","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"25 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139963324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6410
Ebtissam Ameer Mohammed, M. Alfahad, M. Qazzaz
Solubility and dissolution rate are essential factors in the bioavailability of a drug. The drug must be well-soluble in water to have good bioavailability. Solid dispersion is among the most widely used and effective methods for increasing solubility and releasing inadequately water-soluble medications. Solid dispersion requires the choice of a suitable carrier for the right active pharmaceutical ingredients and the proper techniques for preparing solid dispersions. The reliable dispersion system is designed in various ways to achieve the goal and avoid the accompanying obstacles. Keywords: solid dispersion, solubility, solvent evaporation, lyophilization, generation, methods
{"title":"Solid dispersion: application and limitations","authors":"Ebtissam Ameer Mohammed, M. Alfahad, M. Qazzaz","doi":"10.22270/jddt.v14i2.6410","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6410","url":null,"abstract":"Solubility and dissolution rate are essential factors in the bioavailability of a drug. The drug must be well-soluble in water to have good bioavailability. Solid dispersion is among the most widely used and effective methods for increasing solubility and releasing inadequately water-soluble medications. Solid dispersion requires the choice of a suitable carrier for the right active pharmaceutical ingredients and the proper techniques for preparing solid dispersions. The reliable dispersion system is designed in various ways to achieve the goal and avoid the accompanying obstacles. \u0000Keywords: solid dispersion, solubility, solvent evaporation, lyophilization, generation, methods","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"3 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6392
Govinda Reddy G., R. Jat, K. M. Manjanna
The aim of the current study was to design and develop and evaluate pulsatile drug delivery system of Albuterol Sulphate and Theophylline for the treatment of Asthma. The capsule body was made water insoluble by cross linked with formaldehyde vaopur. The treatment of Formalin was adopted to modify the gelatin capsule solubility. The formalin residue was carried out by quantitative test. The drug-excipient compatibility is done by FTIR and UV . The pulsincap formulation were prepared by using hydrogel plug of various components. The drug content of the formulation of pulsincap was found to be in the general range. The invitro drug release studies in ph1.2 .6.2 and 7.4 buffern was noticed to be zero percent and capsule was stable for 2 hours drug the studyF5 formulation batch was selected which was best and good formulation and promoted maximum drug release of 96.29% percentage at phosphate buffers when compared with other formulation. Pulsincap formulation can be adopted for optimum delivery of pellets in the treatment as per chronotherapy Keywords: Theophylline, quantitative test, invitro drug release studies, phosphate buffers6.2 and 7.4.
{"title":"Design, Evaluation and Optimization of Albuterol Sulphate and Theophylline Pulsincap drug delivery system for chronotherapy of Asthma","authors":"Govinda Reddy G., R. Jat, K. M. Manjanna","doi":"10.22270/jddt.v14i2.6392","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6392","url":null,"abstract":"The aim of the current study was to design and develop and evaluate pulsatile drug delivery system of Albuterol Sulphate and Theophylline for the treatment of Asthma. The capsule body was made water insoluble by cross linked with formaldehyde vaopur. The treatment of Formalin was adopted to modify the gelatin capsule solubility. The formalin residue was carried out by quantitative test. The drug-excipient compatibility is done by FTIR and UV . The pulsincap formulation were prepared by using hydrogel plug of various components. The drug content of the formulation of pulsincap was found to be in the general range. The invitro drug release studies in ph1.2 .6.2 and 7.4 buffern was noticed to be zero percent and capsule was stable for 2 hours drug the studyF5 formulation batch was selected which was best and good formulation and promoted maximum drug release of 96.29% percentage at phosphate buffers when compared with other formulation. Pulsincap formulation can be adopted for optimum delivery of pellets in the treatment as per chronotherapy \u0000Keywords: Theophylline, quantitative test, invitro drug release studies, phosphate buffers6.2 and 7.4.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139963069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6401
S. Ouedraogo, T. K. Traoré, Taofick Ishola, Benjamin Ouédraogo, Abdoul Gilchrist Laurent Boly, Gniènèfèrètien Nounaféri Awa Silué, F. Ngolsou, R. Semdé
Feretia apodanthera (Rubiaceae) is used in traditional medicine for the treatment of various pathologies. Its leaves are chewed and swallowed to treat stomach aches, sleep disorders, etc. With the aim of improving the extraction method in order to obtain high contents of phytochemical compounds and good antioxidant activity, this study aimed to highlight the extraction and lyophilization conditions of two extracts (aqueous and hydro-ethanolic) leaves of Feretia apodanthera. An aqueous and hydro-ethanolic extraction was carried out from the leaf powder of Feretia apodanthera, after a maceration plan (mass/volume ratio and extraction time). The extracts obtained were freeze-dried (flask size, filling volume and freeze-drying time) in order to determine the optimal extraction conditions. A phytochemical screening of the extracts with extreme yields of different solvents was carried out by TLC, which led to the determination of certains compounds of interest and the evaluation of the antioxidant activity by the DPPH and FRAP method. The optimal maceration conditions were 02 hours and m/V ratio of 1/20 for the aqueous extract and those of the ethanolic extract were 30 min and m/V ratio of 1/20. The optimal freeze-drying conditions were 60h and a 500ml flask 1/3 filled. The presence of flavonoids, tannins, saponosides, coumarins, triterpenes and sterols has been highlighted. The phenolics compounds contents of hydro-ethanolic lyophilisates were higher than those of aqueous lyophilisates. There was no statistical difference between the antioxidant activity of the different extracts. The optimal conditions will serve as a standard for the production of the extract necessary for the formulation. Keywords : Feretia apodanthera, extraction, freeze-drying, phenolics compounds, antioxidant.
{"title":"Optimization of extraction and lyophilization conditions of Feretia apodanthera (Rubiaceae) leaf powders for galenic formulation","authors":"S. Ouedraogo, T. K. Traoré, Taofick Ishola, Benjamin Ouédraogo, Abdoul Gilchrist Laurent Boly, Gniènèfèrètien Nounaféri Awa Silué, F. Ngolsou, R. Semdé","doi":"10.22270/jddt.v14i2.6401","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6401","url":null,"abstract":"Feretia apodanthera (Rubiaceae) is used in traditional medicine for the treatment of various pathologies. Its leaves are chewed and swallowed to treat stomach aches, sleep disorders, etc. With the aim of improving the extraction method in order to obtain high contents of phytochemical compounds and good antioxidant activity, this study aimed to highlight the extraction and lyophilization conditions of two extracts (aqueous and hydro-ethanolic) leaves of Feretia apodanthera. \u0000An aqueous and hydro-ethanolic extraction was carried out from the leaf powder of Feretia apodanthera, after a maceration plan (mass/volume ratio and extraction time). The extracts obtained were freeze-dried (flask size, filling volume and freeze-drying time) in order to determine the optimal extraction conditions. A phytochemical screening of the extracts with extreme yields of different solvents was carried out by TLC, which led to the determination of certains compounds of interest and the evaluation of the antioxidant activity by the DPPH and FRAP method. \u0000The optimal maceration conditions were 02 hours and m/V ratio of 1/20 for the aqueous extract and those of the ethanolic extract were 30 min and m/V ratio of 1/20. The optimal freeze-drying conditions were 60h and a 500ml flask 1/3 filled. The presence of flavonoids, tannins, saponosides, coumarins, triterpenes and sterols has been highlighted. The phenolics compounds contents of hydro-ethanolic lyophilisates were higher than those of aqueous lyophilisates. There was no statistical difference between the antioxidant activity of the different extracts. \u0000The optimal conditions will serve as a standard for the production of the extract necessary for the formulation. \u0000Keywords : Feretia apodanthera, extraction, freeze-drying, phenolics compounds, antioxidant.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.22270/jddt.v14i2.6377
Shinta Eka Kusuma Dewi, A. A. Wiraguna, G. N. I. Pinatih
Dyslipidemia is closely related to the process of lipid peroxidation. In the non-enzymatic peroxidation process of arachidonic acid, an esterification process occurs and produces a metabolite in the form of isoprostane. The most common isoprostane found is F2-isoprostane. In traditional medicine, breadfruit leaves (Artocarvus altilis) have been widely used due to their antioxidant compounds, such as flavonoids, phenols, tannins, saponins, and other secondary metabolites. This study aims to evaluate the activity of breadfruit leaf ethyl acetate extract in improving the lipid profile and F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus). This study was an experimental study with a pretest-posttest control group design with two treatment groups: fenofibrate 1.65 mg (P1) and breadfruit leaf ethyl acetate extract (760 mg) (P2) for 28 days. Total cholesterol, triglyceride, HDL, LDL, and F2-isoprostane levels were measured before and after treatment expressed in mg/dL. The data were analyzed using a parametric t-paired and t-unpaired test with a 95% confidence level. The study found that breadfruit leaf extract was better than fenofibrate at lowering total cholesterol (pre 172.41 ± 4.93; post 101.24 ± 2.09), triglycerides (pre 172.41 ± 4.93; post 101.24 ± 2.09), LDL (pre 95.78 ± 8.00; post 12.03 ± 10.06), F2-Isoprostane (pre 924.86±10.40; post 432.99±14.17), and raising HDL (pre 102.29 ± 10.40; post 143.89 ± 5.99). In conclusion, ethyl acetate extract is better than fenofibrate in improving lipid profiles and reducing F2-isoprostane in dyslipidemia-induced animal tests. Keywords: breadfruit leaves (Artocarvus altilis), dyslipidemia, F2-Isoprostane, fenofibrate, lipid profile, total cholesterol
血脂异常与脂质过氧化过程密切相关。在花生四烯酸的非酶过氧化过程中，会发生酯化反应，产生异前列烷形式的代谢物。最常见的异前列烷是 F2-异前列烷。在传统医学中，面包果叶（Artocarvus altilis）因其抗氧化化合物（如类黄酮、酚、单宁、皂苷和其他次生代谢物）而被广泛使用。本研究旨在评估面包树叶乙酸乙酯提取物在改善血脂异常诱导的 Wistar 大鼠（Rattus norvegicus）血脂状况和 F2-异前列腺素方面的活性。本研究是一项实验研究，采用前测-后测对照组设计，分为两个治疗组：非诺贝特 1.65 毫克（P1）和面包树叶乙酸乙酯提取物（760 毫克）（P2），为期 28 天。测量治疗前后的总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和 F2-异前列腺素水平，单位为毫克/分升。数据采用参数 t 配对检验和 t 非配对检验进行分析，置信度为 95%。研究发现，在降低总胆固醇（治疗前为 172.41 ± 4.93；治疗后为 101.24 ± 2.09）、甘油三酯（治疗前为 172.41 ± 4.93; post 101.24 ± 2.09), LDL (pre 95.78 ± 8.00; post 12.03 ± 10.06), F2-Isoprostane (pre 924.86 ± 10.40; post 432.99 ± 14.17), and raise HDL (pre 102.29 ± 10.40; post 143.89 ± 5.99).总之，在血脂异常引起的动物试验中，乙酸乙酯提取物在改善血脂状况和降低F2-异前列腺素方面优于非诺贝特。关键词：面包树叶；血脂异常；F2-异前列烷；非诺贝特；血脂概况；总胆固醇
{"title":"Ethyl acetate extract of breadfruit leaves (Artocarvus altilis) improves lipid profile and reduces F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus)","authors":"Shinta Eka Kusuma Dewi, A. A. Wiraguna, G. N. I. Pinatih","doi":"10.22270/jddt.v14i2.6377","DOIUrl":"https://doi.org/10.22270/jddt.v14i2.6377","url":null,"abstract":"Dyslipidemia is closely related to the process of lipid peroxidation. In the non-enzymatic peroxidation process of arachidonic acid, an esterification process occurs and produces a metabolite in the form of isoprostane. The most common isoprostane found is F2-isoprostane. In traditional medicine, breadfruit leaves (Artocarvus altilis) have been widely used due to their antioxidant compounds, such as flavonoids, phenols, tannins, saponins, and other secondary metabolites. This study aims to evaluate the activity of breadfruit leaf ethyl acetate extract in improving the lipid profile and F2-isoprostane in dyslipidemia-induced Wistar rats (Rattus norvegicus). This study was an experimental study with a pretest-posttest control group design with two treatment groups: fenofibrate 1.65 mg (P1) and breadfruit leaf ethyl acetate extract (760 mg) (P2) for 28 days. Total cholesterol, triglyceride, HDL, LDL, and F2-isoprostane levels were measured before and after treatment expressed in mg/dL. The data were analyzed using a parametric t-paired and t-unpaired test with a 95% confidence level. The study found that breadfruit leaf extract was better than fenofibrate at lowering total cholesterol (pre 172.41 ± 4.93; post 101.24 ± 2.09), triglycerides (pre 172.41 ± 4.93; post 101.24 ± 2.09), LDL (pre 95.78 ± 8.00; post 12.03 ± 10.06), F2-Isoprostane (pre 924.86±10.40; post 432.99±14.17), and raising HDL (pre 102.29 ± 10.40; post 143.89 ± 5.99). In conclusion, ethyl acetate extract is better than fenofibrate in improving lipid profiles and reducing F2-isoprostane in dyslipidemia-induced animal tests. \u0000Keywords: breadfruit leaves (Artocarvus altilis), dyslipidemia, F2-Isoprostane, fenofibrate, lipid profile, total cholesterol","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139962816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.22270/jddt.v14i1.6241
L. Soromou, Pierre Faya Léno, Alhassane Kamano, Mamadou Lamarana Souare, Almamy Ousmane Deen Camara, Karifa Camara
The use of antibiotic molecules on poultry farms, while justified by their efficacy, must be carried out rationally, as their uncontrolled use modifies the ecology of bacteria and thus contributes to the selection of multi-resistant bacteria. The aim of this study was to carry out a descriptive survey of antibiotic use on laying hen farms in the sub-prefecture of Friguiagbé (Kindia). To achieve this, surveys were carried out among veterinary service managers, poultry farmers and sales outlets. At the end of our work, we identified the existence of two (2) veterinary pharmaceutical supply establishments. Establishments selling veterinary medicines revealed that Tetracycline is the most widely marketed antibiotic family. The most widely used antibiotic molecules are Tetracolivit and Oxytetracycline (26%); Neoxyvital (13%); Alfaceryl and Panteryl (8%); Limoxin (5%); Enrofloxacin, TTS, Colisol and Amoxillin (3%), which are used either for preventive or curative purposes. Keywords : Antibiotic molecules, poultry farming, laying hens, Guinea
{"title":"Current practices in the veterinary use of antibiotics in poultry laying hens in Friguiagbé (Guinea)","authors":"L. Soromou, Pierre Faya Léno, Alhassane Kamano, Mamadou Lamarana Souare, Almamy Ousmane Deen Camara, Karifa Camara","doi":"10.22270/jddt.v14i1.6241","DOIUrl":"https://doi.org/10.22270/jddt.v14i1.6241","url":null,"abstract":"The use of antibiotic molecules on poultry farms, while justified by their efficacy, must be carried out rationally, as their uncontrolled use modifies the ecology of bacteria and thus contributes to the selection of multi-resistant bacteria. The aim of this study was to carry out a descriptive survey of antibiotic use on laying hen farms in the sub-prefecture of Friguiagbé (Kindia). To achieve this, surveys were carried out among veterinary service managers, poultry farmers and sales outlets. At the end of our work, we identified the existence of two (2) veterinary pharmaceutical supply establishments. Establishments selling veterinary medicines revealed that Tetracycline is the most widely marketed antibiotic family. The most widely used antibiotic molecules are Tetracolivit and Oxytetracycline (26%); Neoxyvital (13%); Alfaceryl and Panteryl (8%); Limoxin (5%); Enrofloxacin, TTS, Colisol and Amoxillin (3%), which are used either for preventive or curative purposes. \u0000Keywords : Antibiotic molecules, poultry farming, laying hens, Guinea","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：