Pub Date : 2024-01-15DOI: 10.22270/jddt.v14i1.6183
B. Archana, Palla Vishwada, Yallapragada Sahithi Sri Charani, Dadi Sneha Shri
Conducting a prospective study on kidney impairment caused by pioglitazone at tertiary care hospitals is the study's goal. The goal is to assess Pioglitazone, mortality, quality of life, and the degree of the medication's harmful side effects in diabetic patients. According to the "Pioglitazone-induced kidney injury" prospective study. Out of 350 trial participants, prolonged pioglitazone use in diabetic patients has been shown to raise serum creatinine levels by up to 11%. Additionally, individuals who have been using pioglitazone for six to ten years are more likely to experience renal injury, with males in the 50–60 year age range being the most common victims. Keywords: Pioglitazone, diabetic, prospective, tertiary care, hospital.
{"title":"To Conduct a Prospective Study on Pioglitazone Induced Kidney Injury in Tertiary Care Hospital","authors":"B. Archana, Palla Vishwada, Yallapragada Sahithi Sri Charani, Dadi Sneha Shri","doi":"10.22270/jddt.v14i1.6183","DOIUrl":"https://doi.org/10.22270/jddt.v14i1.6183","url":null,"abstract":"Conducting a prospective study on kidney impairment caused by pioglitazone at tertiary care hospitals is the study's goal. The goal is to assess Pioglitazone, mortality, quality of life, and the degree of the medication's harmful side effects in diabetic patients. According to the \"Pioglitazone-induced kidney injury\" prospective study. Out of 350 trial participants, prolonged pioglitazone use in diabetic patients has been shown to raise serum creatinine levels by up to 11%. Additionally, individuals who have been using pioglitazone for six to ten years are more likely to experience renal injury, with males in the 50–60 year age range being the most common victims. \u0000Keywords: Pioglitazone, diabetic, prospective, tertiary care, hospital.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"108 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sodium alginate and poloxamer 407 were both studied in order to design a hydrogel-based delivery system as a platform for the formulation of vaginal medecines. Sodium alginate is a natural anionic mucoadhesive polymer while poloxamer 407 is a temperature-sensitive polymer. A commercial alginate was characterized. Then, its solutions (0.5-2 % w/w), poloxamer 407 solutions (16-21.5 % w/w) and their mixtures were prepared. Their rheological properties and the influence of vaginal simulated fluid were assessed. This commercial alginate had a mannuronate-to-guluronate ratio of 1.24, a weight-average molecular weight of 300 000 ± 2% g.mol-1, a polydispersity index of 1.8 ± 3%. Alginate solutions displayed a viscous behavior not suitable for a vaginal administration. Poloxamer solutions and their mixtures with alginate were temperature-sensitive, shear-thinning, non-thixotropic and had an elastic behavior suitable for a vaginal administration. Their resistance to dilution with vaginal fluid could prolonge vaginal residence. Keywords: Formulation, poloxamer 407, rheology, sodium alginate, temperature–sensitive, vaginal fluid, viscoelastic properties.
{"title":"Gels Containing Poloxamer 407 and Sodium Alginate as Vehicles for Vaginal Administration","authors":"Kakwokpo Clémence N’GUESSAN-GNAMAN, Awa Nakognon TUO-KOUASSI, Sandrine AKA-ANY-GRAH, Rosine Désirée CHOUGOUO KENGNE-NKUITCHOU, Apo Laurette Anin, A. Lia, Alain N’GUESSAN, Ismael Dally","doi":"10.22270/jddt.v14i1.6348","DOIUrl":"https://doi.org/10.22270/jddt.v14i1.6348","url":null,"abstract":"Sodium alginate and poloxamer 407 were both studied in order to design a hydrogel-based delivery system as a platform for the formulation of vaginal medecines. Sodium alginate is a natural anionic mucoadhesive polymer while poloxamer 407 is a temperature-sensitive polymer. A commercial alginate was characterized. Then, its solutions (0.5-2 % w/w), poloxamer 407 solutions (16-21.5 % w/w) and their mixtures were prepared. Their rheological properties and the influence of vaginal simulated fluid were assessed. This commercial alginate had a mannuronate-to-guluronate ratio of 1.24, a weight-average molecular weight of 300 000 ± 2% g.mol-1, a polydispersity index of 1.8 ± 3%. Alginate solutions displayed a viscous behavior not suitable for a vaginal administration. Poloxamer solutions and their mixtures with alginate were temperature-sensitive, shear-thinning, non-thixotropic and had an elastic behavior suitable for a vaginal administration. Their resistance to dilution with vaginal fluid could prolonge vaginal residence. \u0000Keywords: Formulation, poloxamer 407, rheology, sodium alginate, temperature–sensitive, vaginal fluid, viscoelastic properties.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.22270/jddt.v14i1.6250
Cicilien Quentin Nongni Piebeng, Bruno Dupon Ambamba Akamba, Fils Armand Ella, Agwe Nicoline Injoh, D. Ngoumen, D. Mandob, J. Ngondi
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{"title":"In silico anti-Alzheimer potential of bioactive compounds in fungi from the African Natural Products Database","authors":"Cicilien Quentin Nongni Piebeng, Bruno Dupon Ambamba Akamba, Fils Armand Ella, Agwe Nicoline Injoh, D. Ngoumen, D. Mandob, J. Ngondi","doi":"10.22270/jddt.v14i1.6250","DOIUrl":"https://doi.org/10.22270/jddt.v14i1.6250","url":null,"abstract":"Download and view PDF for abstract","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139622352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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