Background: Systemic lupus erythematosus (SLE) is an idiopathic autoimmune disease which impacts multiple organs and has various clinical presentations. Among all the organs, the skin is the most frequently affected. Case Presentation: This case report presents a 34-year-old male who presented with severe, itchy, and painful rashes over his right arm and both legs, along with a history of pigmented skin lesions. Initially, the patient was given corticosteroid creams by a dermatologist, but the condition progressed, requiring further investigation. The patient's medical history revealed hypertension and, on review, signs of rashes, fatigue, and arthralgias were noted. Physical examination indicated mild swelling and tenderness in both knees. Additionally, an examination revealed his skin was warm, he had fast capillary refill (<2 seconds), and he had an erythematic rash on the right arm and both legs. A nodular erythema rash was seen on the left leg, along with pigmented skin lesions on the right leg, including a bigger lesion measuring approximately 2.5 cm. Laboratory results indicated increased creatinine, low white blood cell count, anemia, and abnormal protein levels, raising doubts about SLE. Further tests confirmed a raised level of autoantibodies, low complement levels, and positive lupus-related antibodies. Later, the patient was referred to a rheumatologist and an SLE diagnosis was confirmed based on laboratory results and hematological manifestations, mucocutaneous involvement, and lupus nephritis. Treatment initially started with hydroxychloroquine and prednisolone, then tests were repeated and the patient underwent a renal biopsy that revealed focal segmental glomerulosclerosis. He was again prescribed methylprednisolone and prednisolone for three days. The patient's condition resolved and he made a successful recovery. Conclusion: This case demonstrates the multiple clinical manifestations of SLE, the necessity of in-depth investigations, and the requirement for multidisciplinary care to address the intricacies of organ involvement in the disease.
{"title":"A Case Report of a Male with Systemic Lupus Erythematous with First Presentation of Annular Macular Itchy Rashes on his Extremities","authors":"Alyaa Alouthmani, Ashraf ALakkad, Samar Ramli, Marwa Eldegwy","doi":"10.22270/jddt.v14i3.6416","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6416","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is an idiopathic autoimmune disease which impacts multiple organs and has various clinical presentations. Among all the organs, the skin is the most frequently affected. \u0000Case Presentation: This case report presents a 34-year-old male who presented with severe, itchy, and painful rashes over his right arm and both legs, along with a history of pigmented skin lesions. Initially, the patient was given corticosteroid creams by a dermatologist, but the condition progressed, requiring further investigation. The patient's medical history revealed hypertension and, on review, signs of rashes, fatigue, and arthralgias were noted. \u0000Physical examination indicated mild swelling and tenderness in both knees. Additionally, an examination revealed his skin was warm, he had fast capillary refill (<2 seconds), and he had an erythematic rash on the right arm and both legs. A nodular erythema rash was seen on the left leg, along with pigmented skin lesions on the right leg, including a bigger lesion measuring approximately 2.5 cm. Laboratory results indicated increased creatinine, low white blood cell count, anemia, and abnormal protein levels, raising doubts about SLE. Further tests confirmed a raised level of autoantibodies, low complement levels, and positive lupus-related antibodies. \u0000Later, the patient was referred to a rheumatologist and an SLE diagnosis was confirmed based on laboratory results and hematological manifestations, mucocutaneous involvement, and lupus nephritis. Treatment initially started with hydroxychloroquine and prednisolone, then tests were repeated and the patient underwent a renal biopsy that revealed focal segmental glomerulosclerosis. He was again prescribed methylprednisolone and prednisolone for three days. The patient's condition resolved and he made a successful recovery. \u0000Conclusion: This case demonstrates the multiple clinical manifestations of SLE, the necessity of in-depth investigations, and the requirement for multidisciplinary care to address the intricacies of organ involvement in the disease.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"68 S11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6456
S. A. Hussainy, Shaima Shereen
Hypertension is a disease defined as persistently elevated arterial blood pressure (BP) with systolic blood pressure of less than 120 mm Hg and diastolic blood pressure of less than 80 mm Hg. Age is one the most common predictor and non-modifiable risk factor of hypertension. Hypertension is more common among older adults than adults of 40-59 years of age. Gender is another common non-modifiable risk factor of hypertension. On average, hypertension is more common among men than in women. A Prospective observational study was carried out where all the patients of either sex attending general medicine department with established hypertension above 35 years of age were included. A Chi-square test was used to find a significant association between age & gender with hypertension. A p value of or lower than 0.05 was considered to be statistically significant. Majority of the patients 65% were males and 35% were females and common age group was ≥60 years. CNS disorders were found in majority of the patients. Diuretics were the most prescribed class of drugs. There was a steady rise in the number of hypertensive patients with increase in age. Hypertension was more prevalent among males than in females. Factors like age and gender were found to be statistically significant associated with hypertension. Clinical pharmacist at an early stage need to monitor the BP and related risk factors and achieve the therapeutic goals, thereby enhancing the quality life span of the patient. Keywords: Hypertension, Gender, Age distribution, Clinical Pharmacist, Statistical, Blood Pressure
{"title":"Blood Pressure in Relation to Age and Gender","authors":"S. A. Hussainy, Shaima Shereen","doi":"10.22270/jddt.v14i3.6456","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6456","url":null,"abstract":"Hypertension is a disease defined as persistently elevated arterial blood pressure (BP) with systolic blood pressure of less than 120 mm Hg and diastolic blood pressure of less than 80 mm Hg. Age is one the most common predictor and non-modifiable risk factor of hypertension. Hypertension is more common among older adults than adults of 40-59 years of age. Gender is another common non-modifiable risk factor of hypertension. On average, hypertension is more common among men than in women. A Prospective observational study was carried out where all the patients of either sex attending general medicine department with established hypertension above 35 years of age were included. A Chi-square test was used to find a significant association between age & gender with hypertension. A p value of or lower than 0.05 was considered to be statistically significant. Majority of the patients 65% were males and 35% were females and common age group was ≥60 years. CNS disorders were found in majority of the patients. Diuretics were the most prescribed class of drugs. There was a steady rise in the number of hypertensive patients with increase in age. Hypertension was more prevalent among males than in females. Factors like age and gender were found to be statistically significant associated with hypertension. Clinical pharmacist at an early stage need to monitor the BP and related risk factors and achieve the therapeutic goals, thereby enhancing the quality life span of the patient. \u0000Keywords: Hypertension, Gender, Age distribution, Clinical Pharmacist, Statistical, Blood Pressure","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6476
Amit Jaiswal, Anil Kumar Pal, Dharmendra Kumar Sahu, Ranjeet Kumar
This study examines the synthesis and characterization of a macrocyclic complex molecule having the general formula [M-LX2], where M =Hg (II) with schiff base Tetradecahydrodibenzo hexaazacyclooctadecine ligands. Resulted from the interaction between mercury and the diethyl triamine and benzene- 1, 2 diol in an ethanolic solution. Schiff base and its novel mercury (II) Complexes were studied vibrational in the solid state using spectral, 1H-NMR, IR, UV, and antimicrobial activity approaches. We were able to establish the coordination mode of the metal in complexes by comparing the changes in the ligands' and complexes' FT-IR and UV-Visible spectra. Keywords: MERCURY (II), Schiff bases, IR, 1H-NMR, PXRD Spectroscopy.
本研究探讨了通式为[M-LX2]的大环络合物分子的合成和特性，其中 M =汞（II）与 schiff base Tetradecahydrodibenzo hexaazacyclooctadecine 配体。这是汞与二乙基三胺和苯 1，2 二醇在乙醇溶液中相互作用的结果。我们利用光谱、1H-NMR、IR、UV 和抗菌活性等方法研究了希夫碱及其新型汞 (II) 配合物在固态下的振动情况。通过比较配体和配合物的傅立叶变换红外光谱和紫外可见光谱的变化，我们确定了配合物中金属的配位模式。关键词：汞 (II)汞 (II) 希夫碱 红外光谱 1H-NMR PXRD 光谱
{"title":"Synthesis and characterizations of Hg (II) Complex of Macrocyclic complexes compounds Tetradecahydrodibenzo hexaazacyclooctadecine with HgX2 (X= Cl, Br) by Hirshfeld analysis and antimicrobial activity","authors":"Amit Jaiswal, Anil Kumar Pal, Dharmendra Kumar Sahu, Ranjeet Kumar","doi":"10.22270/jddt.v14i3.6476","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6476","url":null,"abstract":"This study examines the synthesis and characterization of a macrocyclic complex molecule having the general formula [M-LX2], where M =Hg (II) with schiff base Tetradecahydrodibenzo hexaazacyclooctadecine ligands. Resulted from the interaction between mercury and the diethyl triamine and benzene- 1, 2 diol in an ethanolic solution. Schiff base and its novel mercury (II) Complexes were studied vibrational in the solid state using spectral, 1H-NMR, IR, UV, and antimicrobial activity approaches. We were able to establish the coordination mode of the metal in complexes by comparing the changes in the ligands' and complexes' FT-IR and UV-Visible spectra. \u0000Keywords: MERCURY (II), Schiff bases, IR, 1H-NMR, PXRD Spectroscopy.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"116 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6439
Augustine Chinedu Ihim, Joy Chiemeka Iloka, C. E. Onah, Patrick Chinedu Obi, N. Osakue, E. Agbo, JC Awalu
Soot arises from burning wood, oils, tires, and other hydrocarbon or organic compounds. Soot is widespread and has a massive detrimental effect on human health, climate, and air quality. The serum levels of Interleukin 4, High sensitivity C-reactive protein, and alanine transaminase activity were evaluated. This cross–sectional study recruited 90 participants consisting of 45 participants exposed to soot (test group) and 45 participants not exposed to soot (control group). The Faculty of Health Sciences and Technology Ethics Committee at Nnamdi Azikiwe University granted ethical approval, and participants’ informed consent was acquired. Interleukin 4 and high sensitivity C-reactive protein levels were determined using the Sandwich ELISA method while the activity of alanine transaminase was determined using the spectrophotometric method. Questionnaires were used to obtain the socio-demographic data of the participants and the body mass index (BMI) was calculated using weight (kg)/height2 (m2). Independent t-test and Pearson’s correlation coefficient were used for statistical analysis and significance was set at p<0.05. The results showed that the mean serum activity of alanine transaminase (9.30 ± 0.28) was significantly lower in the participants exposed to soot compared with the control (9.48 ± 0.37) (p<0.05). However, there was no significant difference in the mean serum levels of Interleukin 4 and high sensitivity C-reactive protein of participants exposed to soot compared with the control (p>0.05). Hence, exposure to soot through the use of firewood did not predispose cooks to systemic inflammation, or cardiovascular and hepatic dysfunctions. Keywords: Soot, alanine transaminase, Interleukin 4, high sensitivity C-reactive protein, inflammation
煤烟产生于木材、油类、轮胎和其他碳氢化合物或有机化合物的燃烧。烟尘的范围很广，对人类健康、气候和空气质量都有巨大的不利影响。本研究评估了血清中白细胞介素 4、高敏 C 反应蛋白和丙氨酸转氨酶活性的水平。这项横断面研究共招募了 90 名参与者，包括 45 名接触煤烟的参与者（测试组）和 45 名未接触煤烟的参与者（对照组）。纳姆迪-阿齐基韦大学健康科学与技术学院伦理委员会批准了这项研究，并征得了参与者的知情同意。白细胞介素 4 和高敏 C 反应蛋白水平采用三明治酶联免疫吸附法测定，丙氨酸转氨酶活性采用分光光度法测定。调查问卷用于获取参与者的社会人口学数据，体重指数（BMI）用体重（千克）/身高2（平方米）计算。统计分析采用独立 t 检验和皮尔逊相关系数，显著性设定为 p0.05）。因此，通过使用木柴接触煤烟并不会导致厨师出现全身炎症、心血管和肝功能异常。关键词煤烟 丙氨酸转氨酶 白细胞介素 4 高敏 C 反应蛋白 炎症
{"title":"Evaluation of Interleukin 4, High Sensitivity C-Reactive Protein and Activity of Alanine Transaminase Among Cooks in Nnewi","authors":"Augustine Chinedu Ihim, Joy Chiemeka Iloka, C. E. Onah, Patrick Chinedu Obi, N. Osakue, E. Agbo, JC Awalu","doi":"10.22270/jddt.v14i3.6439","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6439","url":null,"abstract":"Soot arises from burning wood, oils, tires, and other hydrocarbon or organic compounds. Soot is widespread and has a massive detrimental effect on human health, climate, and air quality. The serum levels of Interleukin 4, High sensitivity C-reactive protein, and alanine transaminase activity were evaluated. This cross–sectional study recruited 90 participants consisting of 45 participants exposed to soot (test group) and 45 participants not exposed to soot (control group). The Faculty of Health Sciences and Technology Ethics Committee at Nnamdi Azikiwe University granted ethical approval, and participants’ informed consent was acquired. Interleukin 4 and high sensitivity C-reactive protein levels were determined using the Sandwich ELISA method while the activity of alanine transaminase was determined using the spectrophotometric method. Questionnaires were used to obtain the socio-demographic data of the participants and the body mass index (BMI) was calculated using weight (kg)/height2 (m2). Independent t-test and Pearson’s correlation coefficient were used for statistical analysis and significance was set at p<0.05. The results showed that the mean serum activity of alanine transaminase (9.30 ± 0.28) was significantly lower in the participants exposed to soot compared with the control (9.48 ± 0.37) (p<0.05). However, there was no significant difference in the mean serum levels of Interleukin 4 and high sensitivity C-reactive protein of participants exposed to soot compared with the control (p>0.05). Hence, exposure to soot through the use of firewood did not predispose cooks to systemic inflammation, or cardiovascular and hepatic dysfunctions. \u0000Keywords: Soot, alanine transaminase, Interleukin 4, high sensitivity C-reactive protein, inflammation","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"45 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutraceuticals refer to food products that have a positive impact on the well-being of individuals. This category includes dietary supplements, herbal products, probiotics, and prebiotics, as well as medical foods designed for disease prevention and treatment. The nutraceutical market is witnessing substantial growth worldwide, primarily due to the growing awareness among consumers about the connection between diet and health. Additionally, there is a rising demand for functional foods and dietary supplements. As consumers prioritize preventive healthcare, they are increasingly looking for products that provide targeted health benefits beyond basic nutrition. The rise of this trend can be attributed to various factors, including the aging population, rising healthcare expenses, and a preference for natural and organic ingredients. Nutraceuticals, as a major force in the industry, offer numerous beneficial effects with minimal undesirable impacts, thus attracting more consumer interest. The increasing shift towards preventive treatments, along with the growth in disposable income and a positive market outlook for the pharmaceutical sector, has primarily contributed to the expanding nutraceutical market in India. However, challenges such as the lack of regulation and awareness, high pricing, marketing, and distribution issues need to be addressed. Nutraceutical market is seeing flowing development chiefly in United States, India, and European nations. This review article primarily focuses on providing a concise overview of nutraceuticals, categorizing them, and discussing their significant roles in various health conditions. Additionally, it delves into the present and future status of nutraceuticals on a global scale. Keywords: traditional cure; nutraceuticals; remedy; prebiotics; probiotics; regulatory compliance; supplementary diets; nutraceutical ingredients.
{"title":"A Traditional Review: The Utilization of Nutraceutical as a Traditional Cure for the Modern World at Current Prospectus for Multiple Health Conditions","authors":"Prachi Pandey, Rahul Pal, Manju Koli, Raj Kumar Malakar, Sandeep Verma, Narendra Kumar, Pavan Kumar","doi":"10.22270/jddt.v14i3.6445","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6445","url":null,"abstract":"Nutraceuticals refer to food products that have a positive impact on the well-being of individuals. This category includes dietary supplements, herbal products, probiotics, and prebiotics, as well as medical foods designed for disease prevention and treatment. The nutraceutical market is witnessing substantial growth worldwide, primarily due to the growing awareness among consumers about the connection between diet and health. Additionally, there is a rising demand for functional foods and dietary supplements. As consumers prioritize preventive healthcare, they are increasingly looking for products that provide targeted health benefits beyond basic nutrition. The rise of this trend can be attributed to various factors, including the aging population, rising healthcare expenses, and a preference for natural and organic ingredients. Nutraceuticals, as a major force in the industry, offer numerous beneficial effects with minimal undesirable impacts, thus attracting more consumer interest. The increasing shift towards preventive treatments, along with the growth in disposable income and a positive market outlook for the pharmaceutical sector, has primarily contributed to the expanding nutraceutical market in India. However, challenges such as the lack of regulation and awareness, high pricing, marketing, and distribution issues need to be addressed. Nutraceutical market is seeing flowing development chiefly in United States, India, and European nations. This review article primarily focuses on providing a concise overview of nutraceuticals, categorizing them, and discussing their significant roles in various health conditions. Additionally, it delves into the present and future status of nutraceuticals on a global scale. \u0000Keywords: traditional cure; nutraceuticals; remedy; prebiotics; probiotics; regulatory compliance; supplementary diets; nutraceutical ingredients.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"19 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6405
Rajdeep Dutta Gopal Dutta, Gautam Kar, Seema Rao
Imuuxanth powder, a dietary supplement enriched with natural antioxidants, is explored for its nutritional properties and potential health benefits. The powder provides 5.26 Kcal energy, 1.90g protein, zero fat and added sugar, and 1.80g fiber per serving. Suitable for low-calorie diets, it supports protein intake, tissue repair, and muscle development. With no fat or added sugar, it aids weight management and blood sugar control. Amino acid analysis highlights its diverse essential and non-essential amino acids. GC-MS identifies flavonoids, xanthones, and carotenoids for antioxidant properties. Antioxidant assays (DPPH, FRAP, ABTS) confirm Imuuxanth's potential to combat oxidative stress. Molecular docking studies predict interactions with proteins related to antioxidant effects. Top berries intensify its antioxidant activity due to active compounds. Imuuxanth powder presents promising nutritional properties, including low energy, moderate protein, and absence of fat and added sugar. Its diverse bioactive compounds contribute to potent antioxidant capabilities. In silico studies support its potential as a dietary supplement for overall health, warranting further research for specific benefits. Keywords: Immuxanth powder, Antioxandant potential, GCMS Analysis, Nutritional Analysis, Insilico Analysis
{"title":"A detailed research on Antioxidant and therapeutic potential of Immuxanth implementing in silico and in vitro approach","authors":"Rajdeep Dutta Gopal Dutta, Gautam Kar, Seema Rao","doi":"10.22270/jddt.v14i3.6405","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6405","url":null,"abstract":"Imuuxanth powder, a dietary supplement enriched with natural antioxidants, is explored for its nutritional properties and potential health benefits. The powder provides 5.26 Kcal energy, 1.90g protein, zero fat and added sugar, and 1.80g fiber per serving. Suitable for low-calorie diets, it supports protein intake, tissue repair, and muscle development. With no fat or added sugar, it aids weight management and blood sugar control. Amino acid analysis highlights its diverse essential and non-essential amino acids. GC-MS identifies flavonoids, xanthones, and carotenoids for antioxidant properties. \u0000Antioxidant assays (DPPH, FRAP, ABTS) confirm Imuuxanth's potential to combat oxidative stress. Molecular docking studies predict interactions with proteins related to antioxidant effects. Top berries intensify its antioxidant activity due to active compounds. Imuuxanth powder presents promising nutritional properties, including low energy, moderate protein, and absence of fat and added sugar. Its diverse bioactive compounds contribute to potent antioxidant capabilities. In silico studies support its potential as a dietary supplement for overall health, warranting further research for specific benefits. \u0000Keywords: Immuxanth powder, Antioxandant potential, GCMS Analysis, Nutritional Analysis, Insilico Analysis","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"14 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension (HTN) Is Prevalent Leading Health Issue Around the World. It is significant cause for cardiovascular morbidity and mortality risk factors? The term "high blood pressure" refers to hypertension. It is long term condition in which the blood pressure in the arteries continuously increased. Distribution of HTN in developed nation, in obese, elderly, pregnancy and now a day’s teenager is also affected. The pathological mechanisms involved in HTN are genetics, sympathetic nervous system over activity, gender differences, cardiac output and peripheral vascular resistance, obstructive sleep apnoea, racial and ethnic factors, and many others. it can be prevented by reducing salt intake, weight loss, exercise, smoking cessation. There are many drugs are available for the treatment of this and its combination therapy is more effective. The pathophysiology, diagnosis, and current state of the disease's management are covered in this study. Keywords: Hypertension, cardiovascular morbidity, cardiac output, peripheral vascular resistance
{"title":"A Basic Review on Hypertension, its Non-Pharmacological and Pharmacological Treatment","authors":"Anjali Singh, Vishal Vishal, Ankit Kumar, S. Sonam, Nitin Kumar, Neelam Sharma","doi":"10.22270/jddt.v14i3.6473","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6473","url":null,"abstract":"Hypertension (HTN) Is Prevalent Leading Health Issue Around the World. It is significant cause for cardiovascular morbidity and mortality risk factors? The term \"high blood pressure\" refers to hypertension. It is long term condition in which the blood pressure in the arteries continuously increased. Distribution of HTN in developed nation, in obese, elderly, pregnancy and now a day’s teenager is also affected. The pathological mechanisms involved in HTN are genetics, sympathetic nervous system over activity, gender differences, cardiac output and peripheral vascular resistance, obstructive sleep apnoea, racial and ethnic factors, and many others. it can be prevented by reducing salt intake, weight loss, exercise, smoking cessation. There are many drugs are available for the treatment of this and its combination therapy is more effective. The pathophysiology, diagnosis, and current state of the disease's management are covered in this study. \u0000Keywords: Hypertension, cardiovascular morbidity, cardiac output, peripheral vascular resistance","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6466
Ghulam Nabi Wani, Afifa Naaz, Wajeeha Begum, Shavana Fathima
Background: Saffron is a significant medicinal herb that has a lot of potential for use in the development of new drugs. Since ancient times, saffron (Crocus sativus L.) has been associated with various health benefits in various parts of the world. Some of these applications have been overlooked over time. However, interest in naturally occurring active compounds has rekindled interest in saffron's past applications and the best applications for saffron today can be aided by knowing its various historical uses. It was prized as a culinary spice as well as a perfume, color, and medicinal herb. It was used medicinally in many different cultures to treat a wide range of ailments, from genitourinary to eye problems. In many countries, it was also used as an antidepressant and tonic substance. Objective: The purpose of this review is to provide an overview of the traditional and modern uses of Crocus sativus, with particular attention to its chemical makeup, pharmacological characteristics, and ethnobotanical description. Methodology: Scientific databases and publications about the chemical profile, biological activity, and historical use of saffron were included in the literature search. Results: Saffron is bitter, acrid, fragrant, stimulant, tonic, stomachic, aphrodisiac, anodyne, antispasmodic, emmenagogue, diuretic, laxative, galactagogue, and helpful in treating bronchitis, vomiting, fever, melancholia, hepatomegaly, etc. it is widely used in alternative medicine, such as the Unani System of Medicine, Ayurveda, and Traditional Chinese Medicine. Saffron has been the subject of numerous phytochemical and biochemical studies due to its extensive use in traditional medical systems. These studies have revealed that saffron contains a number of constituents, including crocetin, safranal, and crocins, the latter of which is primarily responsible for pharmacological actions. Keywords; saffron, medicinal herb, unani medicine, crocetin, safranal, emmenagogue.
{"title":"Unani perspective of Saffron (Crocus sativus Linn.) beyond a spice","authors":"Ghulam Nabi Wani, Afifa Naaz, Wajeeha Begum, Shavana Fathima","doi":"10.22270/jddt.v14i3.6466","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6466","url":null,"abstract":"Background: Saffron is a significant medicinal herb that has a lot of potential for use in the development of new drugs. Since ancient times, saffron (Crocus sativus L.) has been associated with various health benefits in various parts of the world. Some of these applications have been overlooked over time. However, interest in naturally occurring active compounds has rekindled interest in saffron's past applications and the best applications for saffron today can be aided by knowing its various historical uses. It was prized as a culinary spice as well as a perfume, color, and medicinal herb. It was used medicinally in many different cultures to treat a wide range of ailments, from genitourinary to eye problems. In many countries, it was also used as an antidepressant and tonic substance. \u0000Objective: The purpose of this review is to provide an overview of the traditional and modern uses of Crocus sativus, with particular attention to its chemical makeup, pharmacological characteristics, and ethnobotanical description. \u0000Methodology: Scientific databases and publications about the chemical profile, biological activity, and historical use of saffron were included in the literature search. \u0000Results: Saffron is bitter, acrid, fragrant, stimulant, tonic, stomachic, aphrodisiac, anodyne, antispasmodic, emmenagogue, diuretic, laxative, galactagogue, and helpful in treating bronchitis, vomiting, fever, melancholia, hepatomegaly, etc. it is widely used in alternative medicine, such as the Unani System of Medicine, Ayurveda, and Traditional Chinese Medicine. Saffron has been the subject of numerous phytochemical and biochemical studies due to its extensive use in traditional medical systems. These studies have revealed that saffron contains a number of constituents, including crocetin, safranal, and crocins, the latter of which is primarily responsible for pharmacological actions. \u0000Keywords; saffron, medicinal herb, unani medicine, crocetin, safranal, emmenagogue.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6474
Manoj Kumari More
Sixteen depsides were synthesized to screen for their antibacterial activity. All of them were reported for the first time. Their chemical structures were clearly determined by FTIR, 1H NMR, ESI mass spectra. All the compounds were assayed for antibacterial and antifungal activities against two Gram-positive bacterial strains (Bacillus subtilis ATCC 6633) and (Staphylococcus aureus ATCC 29747)and two gram-negative bacterial strains (Escherichia coli ATCC 8739) and (Pseudomonas aeruginosa ATCC 25619) the MIC and zone of inhibition calculated by cup-plate method and serial dilution method and two fungal strains (Aspergillus niger ATCC 90292) and (Candida albicans ATCC 24433)by the micro-broth dilution method.Compound2-(2- propoxy -2-oxoethylphenyl (4-methoxyphenyl)acetate(P6) and 2-(2- propoxy-2-oxoethylphenyl(4-methylphenyl)acetate(P7) showed powerful antibacterial activities against E. coli with MIC of 2.0 40mg/ml while compound 2-(2- propoxy -2-oxoethylphenyl(4-methylphenyl)acetate (P7) and 2-(2- propoxy -2-oxoethylphenyl and (3-methoxyphenyl)acetate (P8) exhibited significant antibacterial activities against B. subtilis with MIC of 3.12 40mg/ml, which were superior to the positive controls amoxycillin trihydrate and ciprofloxacin HCl, respectively and compound 2-(2- propoxy -2-oxoethyl) phenyl 4-methylbenzoate (P8) was found to have highest antifungal activity against Candida albicans ATCC 24433. On the basis of the biological results, quantitative structure activity relationships were discussed. Keywords: Depsides, Antibacterials, Antifungal, Quantitative structure activity relationship.
{"title":"Design, Synthesis, Characterization and Biological Evaluation of Novel Depsides as Potential Antibacterials","authors":"Manoj Kumari More","doi":"10.22270/jddt.v14i3.6474","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6474","url":null,"abstract":"Sixteen depsides were synthesized to screen for their antibacterial activity. All of them were reported for the first time. Their chemical structures were clearly determined by FTIR, 1H NMR, ESI mass spectra. All the compounds were assayed for antibacterial and antifungal activities against two Gram-positive bacterial strains (Bacillus subtilis ATCC 6633) and (Staphylococcus aureus ATCC 29747)and two gram-negative bacterial strains (Escherichia coli ATCC 8739) and (Pseudomonas aeruginosa ATCC 25619) the MIC and zone of inhibition calculated by cup-plate method and serial dilution method and two fungal strains (Aspergillus niger ATCC 90292) and (Candida albicans ATCC 24433)by the micro-broth dilution method.Compound2-(2- propoxy -2-oxoethylphenyl (4-methoxyphenyl)acetate(P6) and 2-(2- propoxy-2-oxoethylphenyl(4-methylphenyl)acetate(P7) showed powerful antibacterial activities against E. coli with MIC of 2.0 40mg/ml while compound 2-(2- propoxy -2-oxoethylphenyl(4-methylphenyl)acetate (P7) and 2-(2- propoxy -2-oxoethylphenyl and (3-methoxyphenyl)acetate (P8) exhibited significant antibacterial activities against B. subtilis with MIC of 3.12 40mg/ml, which were superior to the positive controls amoxycillin trihydrate and ciprofloxacin HCl, respectively and compound 2-(2- propoxy -2-oxoethyl) phenyl 4-methylbenzoate (P8) was found to have highest antifungal activity against Candida albicans ATCC 24433. On the basis of the biological results, quantitative structure activity relationships were discussed. \u0000Keywords: Depsides, Antibacterials, Antifungal, Quantitative structure activity relationship.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"94 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.22270/jddt.v14i3.6463
Ajay Sunil Sabale, A. S. Sabale, Gajendra Kale, Arati Machale, H. V. Kamble, Supriya Hambir
To investigate anti-arthritic activity of Quercetin and Curcumin in Freund's complete adjuvant (FCA)-induced arthritis in rats. AA was induced by injecting with Freund's complete adjuvant (FCA). Rats were randomly divided into six groups with 10 mice in each group: (1) Normal group (saline), (2) Vehicle control, (3) Leflunomide (LF, 10 mg/kg), (4) Curcumin (80), (5) Quercetin (40), (6) Curcumin (80) + Quercetin (40). Male SD rats were subjected to treatment with Lut at 10 mg/kg from days 18 to 24 after immunization. Arthritic scores, tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), paw histopathology and the proteins of P2X4 pathway were assessed at the end of the experiment. Lut reduced the severity of arthritic scores during the experimental period as compared with positive control (RA). Lut significantly suppressed TNF-α and IL-1 as compared with RA group. Histopathological examination indicated that Lut alleviated infiltration of inflammatory cells and synovial hyperplasia as well as protected joint destruction. Lut significantly suppressed inflammatory cells, and Caspase-1p10. Quercetin and Curcumin may be a potential preventive or therapeutic candidate for the treatment of inflammation and arthritis. Keywords: Rheumatoid arthritis, anti-arthritic activity, Quercetin, Curcumin, Freund's complete adjuvant (FCA), Leflunomide, histopathology.
{"title":"To Carry Out Anti-Arthritic Activity of Combination of Quercetin and Curcumin Using FCA (Freund’s Complete Adjuvant) Induced Arthritis in Laboratory Rats","authors":"Ajay Sunil Sabale, A. S. Sabale, Gajendra Kale, Arati Machale, H. V. Kamble, Supriya Hambir","doi":"10.22270/jddt.v14i3.6463","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6463","url":null,"abstract":"To investigate anti-arthritic activity of Quercetin and Curcumin in Freund's complete adjuvant (FCA)-induced arthritis in rats. AA was induced by injecting with Freund's complete adjuvant (FCA). Rats were randomly divided into six groups with 10 mice in each group: (1) Normal group (saline), (2) Vehicle control, (3) Leflunomide (LF, 10 mg/kg), (4) Curcumin (80), (5) Quercetin (40), (6) Curcumin (80) + Quercetin (40). Male SD rats were subjected to treatment with Lut at 10 mg/kg from days 18 to 24 after immunization. Arthritic scores, tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), paw histopathology and the proteins of P2X4 pathway were assessed at the end of the experiment. Lut reduced the severity of arthritic scores during the experimental period as compared with positive control (RA). Lut significantly suppressed TNF-α and IL-1 as compared with RA group. Histopathological examination indicated that Lut alleviated infiltration of inflammatory cells and synovial hyperplasia as well as protected joint destruction. Lut significantly suppressed inflammatory cells, and Caspase-1p10. Quercetin and Curcumin may be a potential preventive or therapeutic candidate for the treatment of inflammation and arthritis. \u0000Keywords: Rheumatoid arthritis, anti-arthritic activity, Quercetin, Curcumin, Freund's complete adjuvant (FCA), Leflunomide, histopathology.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"60 S8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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