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A comparison of methods for coding race in linear and logistic regression models 线性和逻辑回归模型中编码竞争方法的比较。
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.annepidem.2025.10.005
Melody S. Goodman , Ariana Lopez , Anarina L. Murillo , Kristyn A. Pierce
In many public health and clinical research studies that use regression models for analyses, race is often considered a confounder and "controlled" for in the regression model with simple indicators for race and non-Hispanic White as the reference group, without much introspection from the data analyst. From a health equity perspective, multiple issues exist with this approach. We examine and compare several methods for coding race in linear and logistic regression models. We compare several coding methods using a sample of 8097 participants (≥18 years old) from the 2020 New York City Community Health Survey. To illustrate the importance of coding methods for race, we conducted regression analyses to compare the results from six coding approaches: dummy, simple effect, difference (forward and backward), deviation, and analyst-defined coding. Body mass index measured continuously and diabetes status measured dichotomously were the outcome variables in the linear and logistic regression models. Results showed that selecting a coding method has implications for identifying racial health inequities. The reference group selection is critical to measuring racial inequities in health outcomes. This study emphasizes the need to consider the impact of coding techniques on research study design, particularly when racial health inequities are the research focus.
在许多使用回归模型进行分析的公共卫生和临床研究中,种族通常被认为是一个混杂因素,并且在回归模型中以种族和非西班牙裔白人作为参考组的简单指标中被认为是“受控”的,而数据分析师没有进行多少自省。从卫生公平的角度来看,这种方法存在多重问题。我们在线性和逻辑回归模型中检验和比较了几种编码竞赛的方法。我们使用来自2020年纽约市社区健康调查的8,097名参与者(≥18岁)的样本比较了几种编码方法。为了说明编码方法对种族的重要性,我们进行了回归分析,比较了六种编码方法的结果:虚拟、简单效应、差异(向前和向后)、偏差和分析师定义的编码。连续测量体重指数和二分类测量糖尿病状态是线性和逻辑回归模型的结果变量。结果表明,选择一种编码方法对识别种族健康不平等具有重要意义。参照组的选择对于衡量健康结果中的种族不平等至关重要。本研究强调需要考虑编码技术对研究研究设计的影响,特别是当种族健康不平等是研究重点时。
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引用次数: 0
Capturing the implications of residential segregation for the dynamics of infectious disease transmission 捕捉居住隔离对传染病传播动力学的影响。
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.annepidem.2025.11.001
Jon Zelner , Danielle Stone , Marisa C. Eisenberg , Andrew F. Brouwer , Krzysztof Sakrejda

Purpose

Residential segregation is linked to racial and socioeconomic inequity in outcomes for numerous infections including SARS-CoV-2, influenza, STIs, and tuberculosis. Despite the importance of segregation as a driver of infection inequity, there are few mathematical models to inform our understanding of these dynamics.

Methods

We developed a transmission model including mechanistic relationships between residential segregation and infection inequity. We conceptualize segregation as a fundamental social cause of infection inequity that jointly impacts contact patterns and vulnerability to infection.

Results

We show that the basic reproduction number, R0, and equilibrium prevalence are sensitive to interactions between these factors. Our results show that separation alone is insufficient to explain segregation-associated differences in infection risks. Increasing separation only results in concentration of risk in segregated populations when accompanied by increasing vulnerability.

Conclusions

This work shows why it is important to consider causal linkages between high-level social determinants - like segregation - and more-proximal transmission mechanisms when crafting and evaluating public health policies. While the framework in this analysis is stylized, it lays the groundwork for data-driven explorations of the mechanistic impact of residential segregation on infection inequities.
目的:居住隔离与包括SARS-CoV-2、流感、性传播感染和结核病在内的许多感染的结果中的种族和社会经济不平等有关。尽管隔离作为感染不平等的驱动因素很重要,但很少有数学模型可以告诉我们对这些动态的理解。方法:我们建立了一个传播模型,包括居住隔离和感染不平等之间的机制关系。我们将隔离概念化为感染不平等的根本社会原因,它共同影响接触模式和感染脆弱性。结果:基本繁殖数、R0和平衡流行率对这些因素的相互作用较为敏感。我们的研究结果表明,分离本身不足以解释分离相关的感染风险差异。隔离的增加只会导致风险集中在隔离的人群中,同时也会增加脆弱性。结论:这项工作表明,在制定和评估公共卫生政策时,考虑高水平社会决定因素(如隔离)与更近距离传播机制之间的因果关系是很重要的。虽然本分析的框架是程式化的,但它为数据驱动的探索居住隔离对感染不平等的机制影响奠定了基础。
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引用次数: 0
Planning for the sustainability of a youth suicide prevention program in Native American contexts: A modeling study 美国原住民背景下青少年自杀预防计划的可持续性规划:一项模型研究。
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-11-10 DOI: 10.1016/j.annepidem.2025.10.020
Lauren Yan , Zhixi Chen , Novalene Goklish , Kristin Mitchell , Charity Watchman , Meredith Stifter , Victoria O’Keefe , Allison Barlow , Mary Cwik , Takeru Igusa , Emily E. Haroz

Purpose

We aimed to identify actionable, effective sustainment strategies for a community-based suicide prevention program implemented in Tribal contexts through a participatory process of system dynamics modeling.

Methods

Through a series of workshops with teams implementing a suicide prevention program, we prioritized strategies for sustaining implementation and related health outcomes. We used system dynamics modeling and microsimulations to assess the impact of key strategies (increased funding, enhanced program management, and leadership development) on program sustainment outcomes and suicidal behavior among youth.

Results

Enhanced program management impacted sustainment by increasing simulated levels of community trust by 31 % and community and external collaborators by 10 %. Increased funding increased simulated resource availability by 46 % and staffing levels by 13 % over the simulated time frame. Among the three simulated sustainment strategies, enhanced program management most improved clinical outcomes, decreasing non-suicidal self-injury by 1.4 % and suicide attempts by 1.3 %.

Conclusions

We collaboratively developed a simulation model that assessed the relative impact of stakeholders’ prioritized sustainment strategies. A multifaceted intervention for enhanced program management had the greatest impact on program sustainment outcomes. This approach can benefit Tribal communities who are considering methods to support vital community-based programs.

Keywords

System dynamics; Microsimulation; Community-based participatory research; Native American; Suicide prevention; Surveillance; Sustainability

List of abbreviations and acronyms

AI/AN, American Indian and Alaska Native; WMAT, White Mountain Apache Tribe; JHCIH, Johns Hopkins Center for Indigenous Health; C-CASA, Columbia Classification Algorithm for Suicide Assessment; GLS, Garrett Lee Smith Memorial Act; CDC, Centers for Disease Control and Prevention; NHS, National Health Service; SBIRT, Screening, Brief Intervention, Referral to Treatment; PHPCS, Public Health Program Capacity for Sustainability; PSAT, Program Sustainability Assessment Tool; SD, system dynamics; IHS, Indian Health Service
目的:我们旨在通过系统动力学建模的参与性过程,为在部落背景下实施的社区自杀预防计划确定可操作的、有效的维持策略。方法:通过与实施自杀预防计划的团队进行一系列研讨会,我们确定了维持实施和相关健康结果的优先策略。我们使用系统动力学建模和微观模拟来评估关键策略(增加资金、加强项目管理和领导力发展)对项目维持结果和青少年自杀行为的影响。结果:增强的项目管理通过将模拟社区信任水平提高31.9%和伙伴关系提高10.3%来影响可持续发展。在模拟时间框架内,增加的资金使模拟资源可用性提高了51.2%,人员配备水平提高了12.8%。在三种模拟维持策略中,强化项目管理最有效地减轻了临床结果,自杀意念减少0.7%,自我伤害减少1.4%,自杀企图减少1.1%。结论:我们合作开发了一个模拟模型来评估利益相关者优先维持策略的相对影响。加强项目管理的多方面干预对项目维持结果的影响最大。这种方法可以使部落社区受益,考虑如何支持重要的社区项目。关键词(网格):系统动力学;微观分析;基于社区的参与性研究;印第安人;预防自杀;监测;可持续性缩略语和首字母缩略词列表:AI/AN,美洲印第安人和阿拉斯加原住民;D&I,传播和实施;公共卫生方案可持续性能力;PSAT,项目可持续性评估工具;HIS,印第安人健康服务。
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引用次数: 0
Availability of sexual orientation and gender identity (SOGI) information in a cohort of transgender and gender diverse people: An analysis of electronic health records 跨性别者和性别多样化人群的性取向和性别认同(SOGI)信息的可用性:电子健康记录分析
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1016/j.annepidem.2025.10.016
Cynthia N. Ramirez , Michael Goodman , Kristine Magnusson , Wendy Leyden , Alexandra N. Lea , Darios Getahun , Courtney McCracken , Suma Vupputuri , Lee Cromwell , Timothy L. Lash , Oumaima Kaabi , Guneet K. Jasuja , Michael J. Silverberg

Purpose

Electronic health records (EHR) offer a unique opportunity to systematically collect sexual orientation and gender identity (SOGI) data. This study examined the prevalence and determinants of SOGI reporting in an EHR-based cohort of transgender and gender diverse (TGD) individuals.

Methods

We identified TGD people with and without SOGI documentation across four Kaiser Permanente health plans from January 1, 2022–2024. TGD status was determined through clinical notes, diagnostic codes, and SOGI data based on a previously established cohort. Factors associated with SOGI reporting were assessed using log-binomial regression, yielding prevalence ratios (PR) and the 95 % confidence intervals (CI).

Results

Among 23,060 TGD individuals, 71 % had SOGI documentation in the EHR. Reporting varied by sociodemographic and clinical characteristics. For example, compared to those < 20 years, SOGI reporting was higher for those aged 21–59 (PRs 1.10–1.21; 95 % CIs 1.06–1.24) and lower for those > 60 (0.93; 0.88–0.99). Documentation was slightly lower for those assigned male at birth (0.98; 0.97–1.00) and varied by race and ethnicity (e.g., Hispanic: 0.97; 0.95–0.99; Other: 1.02; 0.98–1.05 vs. White).

Conclusions

KP’s EHRs captured SOGI data for over 70 % of TGD individuals, though more research is needed to understand factors associated with missing data not captured in structured fields.
目的:电子健康记录(EHR)为系统地收集性取向和性别认同(SOGI)数据提供了独特的机会。本研究调查了基于ehr的跨性别和性别多样化(TGD)个体队列中SOGI报告的患病率和决定因素。方法:从2022年1月1日至2024年1月1日,我们在四个Kaiser Permanente健康计划中确定了有或没有SOGI文件的TGD患者。TGD状态通过临床记录、诊断代码和基于先前建立的队列的SOGI数据来确定。使用对数二项回归评估与SOGI报告相关的因素,得出患病率(PR)和95%置信区间(CI)。结果:在23,060名TGD患者中,71%在电子病历中有SOGI记录。报告因社会人口学和临床特征而异。例如,与60人相比(0.93;0.88-0.99)。出生时被指定为男性的记录略低(0.98;0.97-1.00),并且因种族和民族而异(例如,西班牙裔:0.97;0.95-0.99;其他:1.02;0.98-1.05 vs.白人)。结论:KP的电子病历捕获了超过70%的TGD个体的SOGI数据,尽管需要更多的研究来了解与结构化领域未捕获的丢失数据相关的因素。
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引用次数: 0
Guiding artificial intelligence in public health and medicine with epidemiology: A lifecycle framework for mitigating AI misalignment 用流行病学指导公共卫生和医学领域的人工智能:减轻人工智能偏差的生命周期框架
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.annepidem.2025.11.004
Ahmed Hassoon MD, MPH , Christine Lin MPH , Hyun Yi (Jacqualine) Woo MD, MPH , Ruxandra Irimia MD, PHD, MPH , Jill A. Marsteller PhD, MPP , Anthony Li MD, PMH , Antonio Banderia MD, MPH , Hubert Leo BS , Xiaoyi Peng ScM , David Rastall MD , Mark Dredze PhD
Artificial Intelligence (AI) holds immense promise for public health, yet its potential is undermined by alignment failures where systems act contrary to human values, often exacerbating health disparities. This paper challenges the narrow view that algorithmic bias is solely a data problem, arguing instead that misalignment arises at every stage of the AI development lifecycle. We introduce a comprehensive seven-stage framework, spanning problem definition, team assembly, study design, data acquisition, model training, validation, and post-deployment implementation, viewed through an epidemiological lens. This approach systematically integrates core principles such as population representativeness, rigorous study design, bias characterization, and causal reasoning to identify and mitigate alignment risks. For each stage, we define specific alignment failures, from flawed problem formulation to post-market performance degradation, and propose actionable, evidence-based solutions. By embedding epidemiological rigor throughout the entire AI lifecycle, this framework provides a structured, proactive pathway for researchers, developers, and policymakers to create trustworthy, safe, and fair AI systems. This systemic approach is critical to harnessing AI's transformative benefits for population health while preventing the perpetuation of inequity and harm.
人工智能(AI)为公共卫生带来了巨大的希望,但其潜力因系统违背人类价值观的一致性失败而受到破坏,往往加剧了健康差距。这篇论文挑战了算法偏差仅仅是数据问题的狭隘观点,相反,它认为在人工智能开发生命周期的每个阶段都会出现偏差。我们通过流行病学视角介绍了一个全面的七阶段框架,涵盖问题定义、团队组建、研究设计、数据获取、模型训练、验证和部署后实施。该方法系统地集成了核心原则,如人口代表性、严格的研究设计、偏见表征和因果推理,以识别和减轻对齐风险。对于每个阶段,我们定义具体的校准失败,从有缺陷的问题制定到上市后性能下降,并提出可操作的、基于证据的解决方案。通过在整个人工智能生命周期中嵌入流行病学严密性,该框架为研究人员、开发人员和政策制定者提供了一个结构化的、主动的途径,以创建值得信赖、安全和公平的人工智能系统。这种系统方法对于利用人工智能对人口健康的变革性益处,同时防止不平等和伤害的持续存在至关重要。
{"title":"Guiding artificial intelligence in public health and medicine with epidemiology: A lifecycle framework for mitigating AI misalignment","authors":"Ahmed Hassoon MD, MPH ,&nbsp;Christine Lin MPH ,&nbsp;Hyun Yi (Jacqualine) Woo MD, MPH ,&nbsp;Ruxandra Irimia MD, PHD, MPH ,&nbsp;Jill A. Marsteller PhD, MPP ,&nbsp;Anthony Li MD, PMH ,&nbsp;Antonio Banderia MD, MPH ,&nbsp;Hubert Leo BS ,&nbsp;Xiaoyi Peng ScM ,&nbsp;David Rastall MD ,&nbsp;Mark Dredze PhD","doi":"10.1016/j.annepidem.2025.11.004","DOIUrl":"10.1016/j.annepidem.2025.11.004","url":null,"abstract":"<div><div>Artificial Intelligence (AI) holds immense promise for public health, yet its potential is undermined by alignment failures where systems act contrary to human values, often exacerbating health disparities. This paper challenges the narrow view that algorithmic bias is solely a data problem, arguing instead that misalignment arises at every stage of the AI development lifecycle. We introduce a comprehensive seven-stage framework, spanning problem definition, team assembly, study design, data acquisition, model training, validation, and post-deployment implementation, viewed through an epidemiological lens. This approach systematically integrates core principles such as population representativeness, rigorous study design, bias characterization, and causal reasoning to identify and mitigate alignment risks. For each stage, we define specific alignment failures, from flawed problem formulation to post-market performance degradation, and propose actionable, evidence-based solutions. By embedding epidemiological rigor throughout the entire AI lifecycle, this framework provides a structured, proactive pathway for researchers, developers, and policymakers to create trustworthy, safe, and fair AI systems. This systemic approach is critical to harnessing AI's transformative benefits for population health while preventing the perpetuation of inequity and harm.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"112 ","pages":"Pages 119-126"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piloting the novel Evidence Synthesis Equity Companion (ESEC) tool 试点新的证据综合公平配套工具。
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-11-13 DOI: 10.1016/j.annepidem.2025.11.002
Maria Benkhalti, Talia Salzman, Prinon Rahman, Ayan Hashi, Laura Boland, Mallory Drysdale

Introduction

The need for greater evidence on equity-denied population groups continues to be recognized across public health, epidemiology, and community medicine. Despite a number of existing frameworks and tools on the inclusion of equity considerations in evidence syntheses, there was a gap in tools providing step-wise guidance and facilitating the documentation of the process.

Methods

We adapted the Equity Checklist for Health Technology Assessment (ECHTA) to the more specific steps of an evidence synthesis. We complemented the guidance provided from seminal resources with articles from a comprehensive literature search and input from expert methodologists. We piloted the tool with a rapid review on substance-related mortality across racialized and ethic groups. We reported on the methodological changes following the use of the tool and the limitations we have observed.

Results

The Evidence Synthesis Equity Companion (ESEC) tool provides guidance and structure to considering equity and the methods to use at each step of an evidence synthesis. It allows review authors to transparently document their process and explicitly highlight its limitations. During the pilot, using the ESEC tool resulted in enhanced approaches to answer the equity-focused review question. Certain limitations remain with the tools, notably a more thorough guidance development for incorporating equity in the knowledge translation process.

Conclusion

The ESEC tool provides structured guidance, supporting the incorporation of equity considerations throughout the evidence synthesis process. The pilot demonstrated its benefits both for the methods used and the evidence uncovered. Additionally, the process was valuable to the review team. Using the tool in different types of evidence syntheses will allow for greater insight into its value-added.
在公共卫生、流行病学和社区医学领域,需要更多关于被剥夺公平的人群的证据。尽管有一些关于将公平考虑因素纳入证据综合的现有框架和工具,但在提供分步指导和促进记录这一进程的工具方面存在差距。方法:我们将卫生技术评估公平检查表(ECHTA)调整为证据综合的更具体步骤。我们用综合文献检索的文章和专家方法学家的输入补充了开创性资源提供的指导。我们对该工具进行了试点,对不同种族和族裔群体的药物相关死亡率进行了快速审查。我们报告了使用该工具后方法的变化以及我们观察到的局限性。结果:证据合成公平伴侣(ESEC)工具为在证据合成的每个步骤中考虑公平和使用的方法提供了指导和结构。它允许评审作者透明地记录他们的过程,并明确地强调其局限性。在试点期间,使用ESEC工具改进了回答以股权为重点的审查问题的方法。这些工具仍然存在一定的局限性,特别是在知识转化过程中纳入公平的更彻底的指导发展。结论:ESEC工具提供了结构化的指导,支持在整个证据合成过程中纳入公平考虑。该试点项目展示了其所使用的方法和发现的证据的好处。此外,该过程对评审团队是有价值的。在不同类型的证据合成中使用该工具将有助于更深入地了解其价值。
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引用次数: 0
Trends and cyclical patterns of dengue disease in Mexico: A 40-year time series analysis 墨西哥登革热的趋势和周期性模式:40年时间序列分析。
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-11-02 DOI: 10.1016/j.annepidem.2025.10.022
Jaime Briseno-Ramirez , Judith Carolina De Arcos-Jiménez , Ana María López-Yáñez , Roberto Miguel Damián-Negrete , Patricia Noemi Vargas-Becerra , Laura Karina Salas-Salazar , Berenice Martínez-Melendres , Ismael Caballero-Quirarte , Pedro Martínez-Ayala

Purpose

To quantify long-term trends and multi-year cycles in dengue in Mexico (1985–2025) and examine recent serotype–severity patterns.

Methods

We integrated open national surveillance data from the Morbidity Yearbook (1985–2024) and Open Data (2020–2025) using the official estimated-cases definition. Monthly series underwent STL decomposition, Butterworth filtering, periodogram, and autocorrelation analyses. Stationarity was assessed in prespecified windows (1985–2000; 2000–2015; 2015–2025) and by geography (coastal/high-burden vs inland). Serotype distribution and hospitalizations (2020–2025) were summarized among laboratory-confirmed cases and compared across years with χ² tests.

Results

Over 40 years we identified 1715,456 estimated cases; annual burden increased (Mann–Kendall z = 3.25; Sen’s slope ≈ +1275 cases/year). A recurrent multi-year oscillation overlaid the seasonal cycle, with a spectral peak near 5.8 years and an ACF secondary maximum at ∼4.3 years; the signal persisted in coastal/high-burden states and across historical windows. Since 2023, DENV-3 predominated (86 % in 2024; 94.9 % by May-2025) and coincided with higher hospitalization proportions.

Conclusions

Dengue in Mexico shows a significant long-term rise and a reproducible ∼5-year cycle. Cycle-aware baselines, paired with serotype surveillance, could sharpen early-warning thresholds and targeting of vector control.
目的:量化墨西哥登革热(1985-2025)的长期趋势和多年周期,并检查最近的血清型严重程度模式。方法:我们使用官方估计病例定义整合了来自发病率年鉴(1985-2024)和开放数据(2020-2025)的开放国家监测数据。每月序列进行STL分解、巴特沃斯滤波、周期图和自相关分析。在预先指定的窗口(1985-2000年;2000-2015年;2015-2025年)和地理(沿海/高负担vs内陆)评估平稳性。总结实验室确诊病例的血清型分布和住院情况(2020-2025年),并用χ 2检验比较各年之间的差异。结果:40多年来,我们确定了1,715,456例估计病例;年负担增加(Mann-Kendall z=3.25; Sen’s斜率≈+1275例/年)。多年振荡复盖在季节周期上,光谱峰值在5.8 A左右,ACF二次最大值在4.3 A左右;该信号在沿海/高负担州持续存在,并跨越历史窗口。自2023年以来,DENV-3占主导地位(2024年为86%,到2025年5月为94.9%),同时住院率较高。结论:登革热在墨西哥呈现显著的长期上升趋势和可重复的5年周期。周期意识基线与血清型监测相结合,可提高早期预警阈值和媒介控制的目标。
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引用次数: 0
The American College of Epidemiology Annals of Epidemiology Award, 2025 美国流行病学学会流行病学年鉴奖,2025年
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-12-01 Epub Date: 2025-11-26 DOI: 10.1016/j.annepidem.2025.11.007
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引用次数: 0
Temporal trends and source attribution of animal-contact related human nontyphoidal Salmonella enterica outbreaks across the United States, 2009–2022 2009-2022年美国与动物接触相关的人类非伤寒沙门氏菌暴发的时间趋势和来源归因
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-01 Epub Date: 2025-10-07 DOI: 10.1016/j.annepidem.2025.10.008
Hammad Ur Rehman Bajwa , Suman Bhowmick , Csaba Varga

Purpose

Previous studies have assessed nontyphoidal Salmonella enterica (NTS) outbreaks associated with animal contact over short periods or single exposures. This study longitudinally evaluates the incidence, temporal trends, and all relevant exposure sources of NTS outbreaks attributed to animal contact in the United States (US) from 2009 to 2022.

Methods

Surveillance data on animal-contact-related NTS single-state outbreaks in the US, reported to the Centers for Disease Control and Prevention through the National Outbreak Reporting System between 2009 and 2022, were analyzed. First, yearly and state-specific NTS outbreak incidence rates (IRs) per one million population years (1 MPY) were calculated. Next, join point regression models assessed national and state-specific trends in NTS IRs over the study years. Lastly, the proportion of NTS outbreaks attributed to various animal contact sources was described.

Results

During the 14 years, 104 NTS outbreaks were reported (0.02 per 1 MPY). The highest outbreak IRs were observed in 2014 (0.0534 per 1 MPY), 2018 (0.0459), and 2009 (0.0389). The join point regression analysis did not identify a significant trend in the national NTS outbreak IRs; however, several states were identified with increasing and/or decreasing trends. Contact with mammals was the main exposure category (n = 37 outbreaks, 35.58 %), followed by birds (n = 31, 29.81 %) and reptiles (n = 24).

Conclusions

Continued public health resources to mitigate the health burden of NTS infections are needed. Differences in state-level NTS outbreak IRs call for focused NTS prevention and control programs.
目的:以前的研究评估了与动物短时间接触或单次接触有关的非伤寒沙门氏菌(NTS)暴发。本研究对2009年至2022年美国由动物接触引起的NTS暴发的发病率、时间趋势和所有相关暴露源进行了纵向评估。方法:分析2009年至2022年间通过国家疫情报告系统向美国疾病控制与预防中心报告的美国动物接触相关NTS单州暴发的监测数据。首先,计算了每百万人年(1mpy)的年度和州特异性NTS暴发发病率(IRs)。接下来,连接点回归模型评估了在研究期间NTS IRs的国家和州特定趋势。最后,描述了由各种动物接触源引起的NTS暴发的比例。结果:在14年中,报告了104例NTS暴发(每1年0.02例)。2014年(0.0534 / 1年)、2018年(0.0459 / 1年)和2009年(0.0389 / 1年)暴发ir最高。联结点回归分析没有发现国家NTS暴发ir的显著趋势;然而,几个州被确定为增加和/或减少的趋势。接触哺乳动物为主要暴露类型(37例,占35.58%),其次为鸟类(31例,占29.81%)和爬行动物(24例)。结论:需要持续的公共卫生资源来减轻NTS感染的健康负担。各州NTS暴发的差异要求有重点的NTS预防和控制规划。
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引用次数: 0
Associations between BMI, body size perception, and dropout from upper secondary education: A prospective cohort study of 15–19-year-old adolescents BMI、体型感知和高中辍学之间的关系:一项对15 - 19岁青少年的前瞻性队列研究
IF 3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-11-01 Epub Date: 2025-10-08 DOI: 10.1016/j.annepidem.2025.10.010
Laura Staxen Bruun , Cecilie Bladt , Katrine Strandberg-Larsen , Vibeke Tornhøj Christensen , Jane Greve , Elisabeth Reichel Hansen , Janne S. Tolstrup

Purpose

To examine the independent associations of BMI and body size perception with dropout from upper secondary education.

Methods

Data from the Danish National Youth Study 2014, including 63,976 students aged 15–19 years, were linked to information on school dropout from the Student Register. Multilevel logistic regressions were employed to examine how BMI and body size perception were each associated with school dropout. Mediation analyses were conducted to assess the role of body size perception in the BMI-dropout association.

Results

Both low and high BMI were associated with higher odds of school dropout, following a U-shaped pattern across the BMI continuum. For instance, females with a BMI above 30 kg/m2 had an OR of 2.37 (95 % CI: 1.74;3.27), compared to those with a BMI of 18.5–24.9 kg/m2. Adjusting for body size perception, ORs attenuated for students with a BMI above the median. Body size perception mediated a substantial proportion of the BMI-dropout association. Students who perceived themselves as too thin or fat also had higher odds of dropout. For instance, females who perceived themselves as ‘much too fat’ had an OR of 2.66 (95 % CI: 2.17;3.25), compared to those who perceived themselves as ‘about right size’. Adjusting for BMI had only minor impact on ORs.

Conclusion

Low and high BMI, as well as the perception of not being the right size, were associated with higher odds of dropout from upper secondary education. Adjusted for body size perception, the association between BMI and dropout attenuated, suggesting that body size perception plays a crucial role in this relationship. Body size perception partly explains the BMI-dropout relationship, highlighting a need for more comprehensive approaches focusing adolescents’ perceptions of their bodies alongside actual weight to reduce school dropout.
目的探讨身体质量指数、体型感知与高中辍学率的独立关系。方法来自2014年丹麦国家青年研究的数据,包括63976名15-19岁的学生,与学生登记册中的辍学信息相关联。采用多水平逻辑回归来检验BMI和体型感知与辍学之间的关系。进行中介分析以评估身体尺寸感知在bmi -辍学关联中的作用。结果BMI指数高和低都与较高的辍学率相关,在BMI连续体上呈u型模式。例如,与BMI为18.5-24.9 kg/m2的女性相比,BMI高于30 kg/m2的女性的OR为2.37(95 % CI: 1.74;3.27)。调整体型感知后,BMI高于中位数的学生的or值减弱。体型感知在bmi与辍学之间起着重要的中介作用。认为自己太瘦或太胖的学生退学的几率也更高。例如,认为自己“太胖”的女性与认为自己“身材适中”的女性相比,OR为2.66(95 % CI: 2.17;3.25)。调整BMI对ORs的影响很小。结论高、低体重指数,以及自我感觉体型不合适,与高中辍学率高相关。调整体型感知后,BMI和辍学之间的关联减弱,表明体型感知在这一关系中起着至关重要的作用。身体尺寸感知在一定程度上解释了bmi与辍学的关系,强调需要更全面的方法来关注青少年对自己身体的感知和实际体重,以减少辍学。
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Annals of Epidemiology
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