Inas Hazim Hameed, Mohammed Hasan Barrak, Farah Ali Dawood
The main hormone in men, testosterone, controls sex differentiation, spermatogenesis, male sex characteristics, and fertility. Low testosterone in men affects several organ systems. Low testosterone affects men's health in physiological ways that affect mood, bone density, muscle mass and strength, and cognitive function. The history, physical examination, clinical symptoms, and testosterone levels are used to make a differential diagnosis. A deficit in iron, commonly brought on by blood loss or other illnesses, results in iron deficiency anemia. The extracellular and intracellular fluids include electrolytes. The main cation and anion in the extracellular fluid are sodium and chloride, respectively. Potassium is the main cation in the intracellular fluid. Electrolytes are essential for preserving homeostasis.
{"title":"Measuring the Levels of Iron, Sodium, Potassium and Chloride in Male Humans with Male Hormone Imbalance","authors":"Inas Hazim Hameed, Mohammed Hasan Barrak, Farah Ali Dawood","doi":"10.55544/jrasb.3.1.34","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.34","url":null,"abstract":"The main hormone in men, testosterone, controls sex differentiation, spermatogenesis, male sex characteristics, and fertility. Low testosterone in men affects several organ systems. Low testosterone affects men's health in physiological ways that affect mood, bone density, muscle mass and strength, and cognitive function. The history, physical examination, clinical symptoms, and testosterone levels are used to make a differential diagnosis. A deficit in iron, commonly brought on by blood loss or other illnesses, results in iron deficiency anemia. The extracellular and intracellular fluids include electrolytes. The main cation and anion in the extracellular fluid are sodium and chloride, respectively. Potassium is the main cation in the intracellular fluid. Electrolytes are essential for preserving homeostasis.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study aimed, through the use of taxonomic associations, to find the genetic relationship between strains of Escherichia coli bacteria in 152 samples of infection symptoms. The results of the susceptibility test for 42 isolates showed that 8 isolates were sensitive to most antibiotics, while 12 isolates had moderate resistance, ranging from 5-8 antagonists, while 22 isolates were resistant to 9-12 antibiotics. Through the use of phylo-group profiling system it was found that the vast majority of Escherichia coli isolates under study have high virulence factors and possess large genomes by belonging to group B2. The results of genotyping using the PCR-Integron system showed that the unty Pable isolates were only... and that the highest percentage was in the first type, which reached... which indicates that there is a relationship between resistance to multiple antibiotics and the presence of introns.
{"title":"Typing and Integron Distribution among Multi-Drug Resistance Escherichia coli","authors":"M. R. Ali, Husam Ahmed AL-Nuaeyme","doi":"10.55544/jrasb.3.1.35","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.35","url":null,"abstract":"The study aimed, through the use of taxonomic associations, to find the genetic relationship between strains of Escherichia coli bacteria in 152 samples of infection symptoms. The results of the susceptibility test for 42 isolates showed that 8 isolates were sensitive to most antibiotics, while 12 isolates had moderate resistance, ranging from 5-8 antagonists, while 22 isolates were resistant to 9-12 antibiotics. Through the use of phylo-group profiling system it was found that the vast majority of Escherichia coli isolates under study have high virulence factors and possess large genomes by belonging to group B2. The results of genotyping using the PCR-Integron system showed that the unty Pable isolates were only... and that the highest percentage was in the first type, which reached... which indicates that there is a relationship between resistance to multiple antibiotics and the presence of introns.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neurology still puzzles about multiple sclerosis (MS). This comprehensive overview explores MS's history, epidemiology, etiology, clinical manifestations, diagnostic tools, and treatment options. From historical awareness to cutting-edge research, we traverse MS's complex world with a focus on the past and future. Genetics, environment, and migration interact to create geographic riddles in MS prevalence. MS's sensory and cognitive symptoms show its significant influence. Advanced imaging technology and diagnostic criteria enable accurate and quick identification. While transformational, disease-modifying treatments require a tailored approach. Advances have left crucial gaps, prompting researchers, physicians, and policymakers to continue. This in-depth investigation of MS combines historical and future perspectives to emphasize the urgency and possibility of solving this complicated neurological puzzle.
{"title":"Article Review: Multiple Sclerosis","authors":"May Y. Al-ma'mouri Al-ma'mouri","doi":"10.55544/jrasb.3.1.29","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.29","url":null,"abstract":"Neurology still puzzles about multiple sclerosis (MS). This comprehensive overview explores MS's history, epidemiology, etiology, clinical manifestations, diagnostic tools, and treatment options. From historical awareness to cutting-edge research, we traverse MS's complex world with a focus on the past and future. Genetics, environment, and migration interact to create geographic riddles in MS prevalence. MS's sensory and cognitive symptoms show its significant influence. Advanced imaging technology and diagnostic criteria enable accurate and quick identification. While transformational, disease-modifying treatments require a tailored approach. Advances have left crucial gaps, prompting researchers, physicians, and policymakers to continue. This in-depth investigation of MS combines historical and future perspectives to emphasize the urgency and possibility of solving this complicated neurological puzzle.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present case-control study, blood specimens were obtained from (60) patients infected with TB from TB center in Baghdad city, and from (60) healthy persons as a control group during the period from January 2023 to December 2023. Results of demographic picture showed that the distribution of infections in males was 31(51.7%) compared to the control group 3(51.7%) and in females was 29 (48.3%) compared to the control group 29 (48.3%). The infection distribution according to age revealed that the highest infection rate was shown to be within the age group (<20 -29), followed by (30-39) then (40-50) years, which matched with the control group (<20 -29). According to residency, there were no significant differences between rural and urban residents. Mean ±Std anti TB IgM antibodies was (2.40±1.44) in comparison with controls (0.08±0.17), with highly significant difference (P<0.01). Also, Mean ±Std anti TB IgG antibodies was (1.42±0.59) in comparison to controls (0.11±0.21), with highly a significant differences P< 0.01. Mean±Std IL-33 was (20.38±6.53) in comparison to the controls (2.28±2.48), with highly significant differences P<0.01. Also, mean ±Std IL-32 was (10.61±2.24) in comparison to the control group (1.89±2.043) with highly significant differences P< 0.01. Expression of IL32 in TB patients showed positive reaction and it was highly affected in patients with TB compared to the control group, while expression of IL33 in TB patients showed positive reaction and was highly affected in patients with TB compared to the control group.
{"title":"Expression of IL32 and IL33 Genes in Tuberculosis Patients","authors":"Bushra Qasim Dhumad","doi":"10.55544/jrasb.3.1.30","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.30","url":null,"abstract":"In the present case-control study, blood specimens were obtained from (60) patients infected with TB from TB center in Baghdad city, and from (60) healthy persons as a control group during the period from January 2023 to December 2023. Results of demographic picture showed that the distribution of infections in males was 31(51.7%) compared to the control group 3(51.7%) and in females was 29 (48.3%) compared to the control group 29 (48.3%). The infection distribution according to age revealed that the highest infection rate was shown to be within the age group (<20 -29), followed by (30-39) then (40-50) years, which matched with the control group (<20 -29). According to residency, there were no significant differences between rural and urban residents. Mean ±Std anti TB IgM antibodies was (2.40±1.44) in comparison with controls (0.08±0.17), with highly significant difference (P<0.01). Also, Mean ±Std anti TB IgG antibodies was (1.42±0.59) in comparison to controls (0.11±0.21), with highly a significant differences P< 0.01. Mean±Std IL-33 was (20.38±6.53) in comparison to the controls (2.28±2.48), with highly significant differences P<0.01. Also, mean ±Std IL-32 was (10.61±2.24) in comparison to the control group (1.89±2.043) with highly significant differences P< 0.01. Expression of IL32 in TB patients showed positive reaction and it was highly affected in patients with TB compared to the control group, while expression of IL33 in TB patients showed positive reaction and was highly affected in patients with TB compared to the control group.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lamiaa Saoud Abbod, Fatima Amer Abd Algabar, Dhea Sadi Ahmed
Cardiovascular danger elements include fatness, high blood pressure, diabetes, and hyperglycemia, and dyslipidemia are all linked to vitamin D insufficiency aside from cardiovascular disease itself. The purpose of this analysis was to look at how children who were not obese related their lipid profiles to their vitamin D levels. The study, which involved 26 Iraqi patients, revealed that the lipid profile was affected by the vitamin D level. Correlation between Vitamin D3 and cholesterol showed asignificant at the 0.05 level (0.960), and between Triglyceride showed (0.857) significant at the 0.05 level.and in the VLDL, LDL, HDL also showed significant at the 0.05 level ( -0.915, -0.974, -0.971).
心血管危险因素包括肥胖、高血压、糖尿病和高血糖，除了心血管疾病本身之外，血脂异常都与维生素 D 不足有关。这项分析的目的是研究非肥胖儿童的血脂状况与维生素 D 水平的关系。这项涉及 26 名伊拉克病人的研究显示，血脂状况受到维生素 D 水平的影响。维生素 D3 与胆固醇之间的相关性在 0.05 水平（0.960）上显著，与甘油三酯之间的相关性在 0.05 水平（0.857）上显著，在 VLDL、LDL、HDL 之间的相关性也在 0.05 水平（-0.915、-0.974、-0.971）上显著。
{"title":"Association between Lipid Profile and Vitamin D Level","authors":"Lamiaa Saoud Abbod, Fatima Amer Abd Algabar, Dhea Sadi Ahmed","doi":"10.55544/jrasb.3.1.36","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.36","url":null,"abstract":"Cardiovascular danger elements include fatness, high blood pressure, diabetes, and hyperglycemia, and dyslipidemia are all linked to vitamin D insufficiency aside from cardiovascular disease itself. The purpose of this analysis was to look at how children who were not obese related their lipid profiles to their vitamin D levels. The study, which involved 26 Iraqi patients, revealed that the lipid profile was affected by the vitamin D level. Correlation between Vitamin D3 and cholesterol showed asignificant at the 0.05 level (0.960), and between Triglyceride showed (0.857) significant at the 0.05 level.and in the VLDL, LDL, HDL also showed significant at the 0.05 level ( -0.915, -0.974, -0.971).","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Whitefly, Bemisia tabaci is one of the major injurious sucking pests in tropical and subtropical regions. The effect of the insecticide Hulk, which is used to kill the whitefly, was revealed, and its effect on some of its genes and the genes of the cucumber plant that parasitizes it, was revealed. Materials and Methods: The current study was conducted in Kirkuk Governorate. DNA was extracted from whiteflies treated with Hulk pesticides and not treated with pesticides as a control, and DNA was also extracted from cucumber leaves treated with the Hulk pesticide and not treated with the pesticide as a control in order to compare them. detecting the specific primer of gene 28s in the whitefly Bemisia tabaci and Matk gene in the plant Cucumis sativus. Three treatments of each pesticide at three concentrations (25% a quarter lethal, 50% half lethal, 100% lethal). Results: The research found that 25% of the pesticide Halk killed 20% of the insects, 50% killed 40%, and 100% killed 70% within 24 hours. Pesticide Hulk found that cucumber plant mutations in the Matk gene and gene 28s had the best insecticidal effects against whitefly Bemisa tabaci. Conclusions: Overall, results suggest that ethanolic DNA extracts pesticide Hulk is the occurrence of mutations in the Matk gene in the plant Cucumis sativus and gene 28s in the whitefly Bemisia tabaci showed the highest insecticidal effects on whitefly Bemisa tabaci.
背景： 烟粉虱（Bemisia tabaci）是热带和亚热带地区的主要吸浆害虫之一。本研究揭示了用于杀灭粉虱的杀虫剂 Hulk 的效果，以及它对粉虱基因和寄生粉虱的黄瓜植物基因的影响：本研究在基尔库克省进行。从使用 Hulk 杀虫剂处理过的粉虱和未使用杀虫剂处理过的粉虱身上提取 DNA 作为对照，并从使用 Hulk 杀虫剂处理过的黄瓜叶片和未使用杀虫剂处理过的黄瓜叶片上提取 DNA 作为对照，以便进行比较。每种杀虫剂按三种浓度（25%四分之一致死率、50%半致死率、100%致死率）处理三次。结果 研究发现，在 24 小时内，25% 的农药 Halk 能杀死 20% 的昆虫，50% 能杀死 40%的昆虫，100% 能杀死 70% 的昆虫。农药 Hulk 发现，黄瓜植株的 Matk 基因和 28s 基因突变对烟粉虱的杀虫效果最好：总之，结果表明，乙醇 DNA 提取物杀虫剂 Hulk 是发生突变的植物黄瓜中 Matk 基因和 28s 基因对烟粉虱 Bemisia tabaci 的杀虫效果最好。
{"title":"The Effect of The Insecticide Hulk on Some Genetic Characteristics of The Whitefly and The Cucumber Plant That Parasitizes It","authors":"Rania Ghasan Abd, R. Alsugmiany","doi":"10.55544/jrasb.3.1.37","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.37","url":null,"abstract":"Background: Whitefly, Bemisia tabaci is one of the major injurious sucking pests in tropical and subtropical regions. The effect of the insecticide Hulk, which is used to kill the whitefly, was revealed, and its effect on some of its genes and the genes of the cucumber plant that parasitizes it, was revealed.\u0000Materials and Methods: The current study was conducted in Kirkuk Governorate. DNA was extracted from whiteflies treated with Hulk pesticides and not treated with pesticides as a control, and DNA was also extracted from cucumber leaves treated with the Hulk pesticide and not treated with the pesticide as a control in order to compare them. detecting the specific primer of gene 28s in the whitefly Bemisia tabaci and Matk gene in the plant Cucumis sativus. Three treatments of each pesticide at three concentrations (25% a quarter lethal, 50% half lethal, 100% lethal). \u0000Results: The research found that 25% of the pesticide Halk killed 20% of the insects, 50% killed 40%, and 100% killed 70% within 24 hours. Pesticide Hulk found that cucumber plant mutations in the Matk gene and gene 28s had the best insecticidal effects against whitefly Bemisa tabaci.\u0000Conclusions: Overall, results suggest that ethanolic DNA extracts pesticide Hulk is the occurrence of mutations in the Matk gene in the plant Cucumis sativus and gene 28s in the whitefly Bemisia tabaci showed the highest insecticidal effects on whitefly Bemisa tabaci.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rizwanullah Rafed, Mohammad Hassan Abedi, Sayed Rhaimullah Mushfiq
Poultry is one of the most widespread food industries worldwide. Chicken is the most farmed species, with over 90 million tons of chicken meat produced per year [19]. Eggs have been a human food since ancient times. They are one of nature’s nearly perfect protein foods and have other high-quality nutrients. Eggs are readily digested and can provide a significant portion of the nutrients required daily for growth and maintenance of body tissues. They are utilized in many ways both in the food industry and the home. The term “eggs”, without a prefix, generally relates to chicken eggs and is so considered in this study [23]. Chicken eggs are one of the best sources of high-quality protein along with important vitamins and minerals. In both developed and developing countries an increased egg production and consumption could significantly improve nutritional needs of adults and children. Eggs are also an economical source of nutrients for a healthy diet and life, especially important for the mental development of growing children [19]. The purpose of this study is to describe the nutritional benefits of eggs in the human diet. Hence, in this study methodology/approach; the scientific literature was searched using Medline and key words relevant to eggs, egg nutrients and it is nutritional roles.
{"title":"Nutritional Value of Eggs in Human Diet","authors":"Rizwanullah Rafed, Mohammad Hassan Abedi, Sayed Rhaimullah Mushfiq","doi":"10.55544/jrasb.3.1.28","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.28","url":null,"abstract":"Poultry is one of the most widespread food industries worldwide. Chicken is the most farmed species, with over 90 million tons of chicken meat produced per year [19]. Eggs have been a human food since ancient times. They are one of nature’s nearly perfect protein foods and have other high-quality nutrients. Eggs are readily digested and can provide a significant portion of the nutrients required daily for growth and maintenance of body tissues. They are utilized in many ways both in the food industry and the home. The term “eggs”, without a prefix, generally relates to chicken eggs and is so considered in this study [23]. Chicken eggs are one of the best sources of high-quality protein along with important vitamins and minerals. In both developed and developing countries an increased egg production and consumption could significantly improve nutritional needs of adults and children. Eggs are also an economical source of nutrients for a healthy diet and life, especially important for the mental development of growing children [19]. The purpose of this study is to describe the nutritional benefits of eggs in the human diet. Hence, in this study methodology/approach; the scientific literature was searched using Medline and key words relevant to eggs, egg nutrients and it is nutritional roles.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amle Vandana Sonaji, Ade Rajkumar Pradeep, Chapke Sima Ganesh, Dudhate Gitanjali Sambhaji, Anamika, Roshan Kumar, Amir Nurdini Mziray, E. Boateng, Richard Owusu Nyarko, Paul Owusu Boateng
There is a possibility that diallyl disulfide and diallyl trisulfide can alleviate neuropathic pain in rats that have been subjected to CCI. The mechanisms by which these compounds alleviate pain entail an increase in the levels of H2S, BDNF, and Nrf2 in the sciatic nerve and the dorsal root ganglion (DRG). The use of garlic as a functional food and as a great source of pharmacologically active compounds is widely recognised and generally accepted. One of the most important bioactive components of garlic is called diallyl disulfide (DADS), and it possesses a number of beneficial biological effects. These capabilities include anti-inflammatory, antioxidant, antibacterial, cardiovascular protective, neuroprotective, and anticancer actions. In this review, the biological roles of DADS were reviewed in a systematic manner, and the molecular mechanisms that underlie these functions were explored. We have high hopes that this review will not only offer direction and insight into the existing body of literature, but will also make it possible for future study and the development of DADS for the intervention and treatment of other disorders.
{"title":"Biological Benefits of Diallyl Disulfide, A Garlic-Derived Natural Organic Sulfur Compound","authors":"Amle Vandana Sonaji, Ade Rajkumar Pradeep, Chapke Sima Ganesh, Dudhate Gitanjali Sambhaji, Anamika, Roshan Kumar, Amir Nurdini Mziray, E. Boateng, Richard Owusu Nyarko, Paul Owusu Boateng","doi":"10.55544/jrasb.3.1.24","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.24","url":null,"abstract":"There is a possibility that diallyl disulfide and diallyl trisulfide can alleviate neuropathic pain in rats that have been subjected to CCI. The mechanisms by which these compounds alleviate pain entail an increase in the levels of H2S, BDNF, and Nrf2 in the sciatic nerve and the dorsal root ganglion (DRG). The use of garlic as a functional food and as a great source of pharmacologically active compounds is widely recognised and generally accepted. One of the most important bioactive components of garlic is called diallyl disulfide (DADS), and it possesses a number of beneficial biological effects. These capabilities include anti-inflammatory, antioxidant, antibacterial, cardiovascular protective, neuroprotective, and anticancer actions. In this review, the biological roles of DADS were reviewed in a systematic manner, and the molecular mechanisms that underlie these functions were explored. We have high hopes that this review will not only offer direction and insight into the existing body of literature, but will also make it possible for future study and the development of DADS for the intervention and treatment of other disorders.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140411747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yash Gupta, Riya Shikha, Vishal Rai, Nisha Bano, Soban Khan, Reena Yadav
Bilirubin, a natural product of heme catabolism, has recently emerged as a promising candidate in nanomedicine for the treatment of Reactive Oxygen Species (ROS)-mediated diseases. ROS, including free radicals and other oxygen-derived molecules, play a pivotal role in various pathological conditions such as inflammation, neurodegenerative disorders, and cardiovascular diseases. Bilirubin's potent antioxidant properties make it an attractive therapeutic agent, and recent advancements in nanotechnology have paved the way for its effective delivery and application in treating ROS-related ailments.This abstract delves into the potential of bilirubin-based nanomedicines in combating ROS-induced damage. The encapsulation of bilirubin within nanocarriers enhances its stability, bioavailability, and targeted delivery to affected tissues. The utilization of nanoscale systems not only safeguards bilirubin from degradation but also allows for controlled release, ensuring sustained therapeutic effects.The multifaceted mechanisms of bilirubin action include its ability to scavenge free radicals, modulate inflammatory responses, and protect cellular components from oxidative stress. The encapsulation of bilirubin in nanoparticles further improves its pharmacokinetics, enabling efficient distribution and accumulation at disease sites. Moreover, the nanocarrier systems can be engineered to respond to specific stimuli, facilitating site-specific release of bilirubin in response to the elevated ROS levels characteristic of pathological conditions.This abstract also highlights the versatility of bilirubin nanomedicines in addressing diverse ROS-mediated diseases. From neuroprotection in conditions like Alzheimer's and Parkinson's diseases to alleviating oxidative stress in cardiovascular disorders, bilirubin-based nanotherapeutics exhibit a broad spectrum of applications. The tailored design of nanocarriers allows for personalized treatment approaches, catering to the unique characteristics of each disease state.
{"title":"Bilirubin Nanomedicines for the Treatment of Reactive Oxygen Species (ROS)-Mediated Diseases","authors":"Yash Gupta, Riya Shikha, Vishal Rai, Nisha Bano, Soban Khan, Reena Yadav","doi":"10.55544/jrasb.3.1.25","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.25","url":null,"abstract":"Bilirubin, a natural product of heme catabolism, has recently emerged as a promising candidate in nanomedicine for the treatment of Reactive Oxygen Species (ROS)-mediated diseases. ROS, including free radicals and other oxygen-derived molecules, play a pivotal role in various pathological conditions such as inflammation, neurodegenerative disorders, and cardiovascular diseases. Bilirubin's potent antioxidant properties make it an attractive therapeutic agent, and recent advancements in nanotechnology have paved the way for its effective delivery and application in treating ROS-related ailments.This abstract delves into the potential of bilirubin-based nanomedicines in combating ROS-induced damage. The encapsulation of bilirubin within nanocarriers enhances its stability, bioavailability, and targeted delivery to affected tissues. The utilization of nanoscale systems not only safeguards bilirubin from degradation but also allows for controlled release, ensuring sustained therapeutic effects.The multifaceted mechanisms of bilirubin action include its ability to scavenge free radicals, modulate inflammatory responses, and protect cellular components from oxidative stress. The encapsulation of bilirubin in nanoparticles further improves its pharmacokinetics, enabling efficient distribution and accumulation at disease sites. Moreover, the nanocarrier systems can be engineered to respond to specific stimuli, facilitating site-specific release of bilirubin in response to the elevated ROS levels characteristic of pathological conditions.This abstract also highlights the versatility of bilirubin nanomedicines in addressing diverse ROS-mediated diseases. From neuroprotection in conditions like Alzheimer's and Parkinson's diseases to alleviating oxidative stress in cardiovascular disorders, bilirubin-based nanotherapeutics exhibit a broad spectrum of applications. The tailored design of nanocarriers allows for personalized treatment approaches, catering to the unique characteristics of each disease state.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renuka Anil Jojare, M. Jadhav, Dipak Pandit Chavan
Bioinformatics is an interdisciplinary branch of science that develops methods and software tools for understanding biological data. Bioinformatics include both the power of biological concept and computational method to solve biological problem. It also bridged biological field with speed and accuracy of computer. Pre-design of vaccines by using artificial intelligence model for future upcoming viruses. Using AI throughout the vaccine development process to ensure that virus/pathogen vaccine met the needs of individuals without spending much time. A piece of genetic code that is capable of copying itself and typically has a detrimental effect on body, the pre-design vaccines will be available on one click no need for direct trials on humans. The model gives the predicted information about the upcoming risks for transmitting the disease in future generations by using artificial intelligence. The model is based on artificial intelligences and bioinformatics filed, all data will be presented and analyze simultaneously by the model and will efficiently build the vaccine molecule against the virus. The model provides highest accuracy and speed to sort out the vaccine.
{"title":"Computational Efficacy of Artificial Intelligence Model for in Silico Vaccine Development","authors":"Renuka Anil Jojare, M. Jadhav, Dipak Pandit Chavan","doi":"10.55544/jrasb.3.1.23","DOIUrl":"https://doi.org/10.55544/jrasb.3.1.23","url":null,"abstract":"Bioinformatics is an interdisciplinary branch of science that develops methods and software tools for understanding biological data. Bioinformatics include both the power of biological concept and computational method to solve biological problem. It also bridged biological field with speed and accuracy of computer. Pre-design of vaccines by using artificial intelligence model for future upcoming viruses. Using AI throughout the vaccine development process to ensure that virus/pathogen vaccine met the needs of individuals without spending much time. A piece of genetic code that is capable of copying itself and typically has a detrimental effect on body, the pre-design vaccines will be available on one click no need for direct trials on humans. The model gives the predicted information about the upcoming risks for transmitting the disease in future generations by using artificial intelligence. The model is based on artificial intelligences and bioinformatics filed, all data will be presented and analyze simultaneously by the model and will efficiently build the vaccine molecule against the virus. The model provides highest accuracy and speed to sort out the vaccine.","PeriodicalId":507877,"journal":{"name":"Journal for Research in Applied Sciences and Biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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