Pub Date : 2024-02-16DOI: 10.34104/ejmhs.024.030043
The present study aims to assess the level of psychological resilience among university students, taking into account variables such as gender, specialization, and study level. The significance of this study lies in the unique nature of the target sample, which comprises students from various disciplines and represents a crucial segment and the future foundation of society. To conduct the study, a stratified random sample was selected from three specified universities, with a sampling percentage of 0.05. The study sample consisted of 1060 male and female students. The researcher utilized a self-designed psychological resilience scale to collect data. The obtained data was then analyzed using the Statistical Package for Social Sciences (SPSS) software, employing statistical techniques such as the Pearson correlation coefficient, Alpha-Cronbach coefficient, one-sample t-test, two-independent samples t-test, and one-way analysis of variance. The results indicated a high level of psychological resilience among university students, as reflected in the total score of the resilience scale. Furthermore, statistically significant differences were observed between male and female students regarding their average resilience scores, with males showing higher levels of psychological resilience. However, no significant differences were found between genders in terms of self-efficacy and optimism dimensions on the psychological resilience scale. Moreover, the study revealed no statistically significant differences in the level of psychological resilience among students from different specializations or study levels. The findings contribute to a better understanding of the psychological well-being of this important segment of society, which can inform the development of targeted interventions and support systems to enhance the resilience and overall mental health of university students.
本研究旨在评估大学生的心理复原力水平，同时考虑到性别、专业和学习水平等变量。本研究的意义在于目标样本的独特性，它由来自不同学科的学生组成，代表了社会的重要组成部分和未来基础。为开展研究，我们从三所指定大学中选取了分层随机样本，抽样比例为 0.05。研究样本包括 1060 名男女学生。研究人员利用自行设计的心理复原力量表收集数据。然后，利用社会科学统计软件包（SPSS）软件，采用皮尔逊相关系数、阿尔法-克朗巴赫系数、单样本 t 检验、双独立样本 t 检验和单因素方差分析等统计技术对所获得的数据进行分析。结果表明，大学生的心理复原力水平较高，这体现在复原力量表的总分上。此外，男女生的抗逆力平均得分在统计学上存在显著差异，男生的心理抗逆力水平更高。不过，在心理复原力量表的自我效能感和乐观维度上，男女生之间没有发现明显差异。此外，研究还发现，不同专业或不同学习水平的学生在心理复原力水平上没有明显的统计学差异。研究结果有助于更好地了解社会中这一重要群体的心理健康状况，从而为制定有针对性的干预措施和支持系统提供信息，以提高大学生的抗压能力和整体心理健康水平。
{"title":"Status of the Psychological Resilience among the University Students","authors":"","doi":"10.34104/ejmhs.024.030043","DOIUrl":"https://doi.org/10.34104/ejmhs.024.030043","url":null,"abstract":"The present study aims to assess the level of psychological resilience among university students, taking into account variables such as gender, specialization, and study level. The significance of this study lies in the unique nature of the target sample, which comprises students from various disciplines and represents a crucial segment and the future foundation of society. To conduct the study, a stratified random sample was selected from three specified universities, with a sampling percentage of 0.05. The study sample consisted of 1060 male and female students. The researcher utilized a self-designed psychological resilience scale to collect data. The obtained data was then analyzed using the Statistical Package for Social Sciences (SPSS) software, employing statistical techniques such as the Pearson correlation coefficient, Alpha-Cronbach coefficient, one-sample t-test, two-independent samples t-test, and one-way analysis of variance. The results indicated a high level of psychological resilience among university students, as reflected in the total score of the resilience scale. Furthermore, statistically significant differences were observed between male and female students regarding their average resilience scores, with males showing higher levels of psychological resilience. However, no significant differences were found between genders in terms of self-efficacy and optimism dimensions on the psychological resilience scale. Moreover, the study revealed no statistically significant differences in the level of psychological resilience among students from different specializations or study levels. The findings contribute to a better understanding of the psychological well-being of this important segment of society, which can inform the development of targeted interventions and support systems to enhance the resilience and overall mental health of university students.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"44 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139961736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.34104/ejmhs.024.020029
No prior investigations have evaluated the musculoskeletal (MSK) injuries characteristic of swimming sport in Jordan. This study aimed to identify the most common sports injuries among male and female swimmers in Jordan. Through a survey distributed to the Jordanian Swimming Federation’s registered swimmers, 173 participants (72 female, 101 male) aged 18 to 25 completed the questionnaire. The results of the study showed that the most common injuries were arranged as follows: muscle spasms, muscle cramps, and sprains; 29.8%, 28.6%, and 17.7%, respectively. The most vulnerable areas were the Shoulder 35.3%, followed by the back 14.4 %, the knee 10.7%, and the neck 10.2%. The most common cause of injuries was Inadequate warm-up, where his percentage reached 34%, followed by Overtraining with a percentage of 27%. Reduced training intensity or frequency, impaired stroke technique, limited range of motion or flexibility, and required complete cessation of swimming had the main effectiveness of the swimming performance and training, where the percent was 34.9%, 20.8%,10.3%, and 4.3%, respectively.
{"title":"Comprehensive Study on Musculoskeletal Injuries among Swimmers in Jordan: Causes, Effects, and Prevention Strategies","authors":"","doi":"10.34104/ejmhs.024.020029","DOIUrl":"https://doi.org/10.34104/ejmhs.024.020029","url":null,"abstract":"No prior investigations have evaluated the musculoskeletal (MSK) injuries characteristic of swimming sport in Jordan. This study aimed to identify the most common sports injuries among male and female swimmers in Jordan. Through a survey distributed to the Jordanian Swimming Federation’s registered swimmers, 173 participants (72 female, 101 male) aged 18 to 25 completed the questionnaire. The results of the study showed that the most common injuries were arranged as follows: muscle spasms, muscle cramps, and sprains; 29.8%, 28.6%, and 17.7%, respectively. The most vulnerable areas were the Shoulder 35.3%, followed by the back 14.4 %, the knee 10.7%, and the neck 10.2%. The most common cause of injuries was Inadequate warm-up, where his percentage reached 34%, followed by Overtraining with a percentage of 27%. Reduced training intensity or frequency, impaired stroke technique, limited range of motion or flexibility, and required complete cessation of swimming had the main effectiveness of the swimming performance and training, where the percent was 34.9%, 20.8%,10.3%, and 4.3%, respectively.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"290 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139833750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-15DOI: 10.34104/ejmhs.024.020029
No prior investigations have evaluated the musculoskeletal (MSK) injuries characteristic of swimming sport in Jordan. This study aimed to identify the most common sports injuries among male and female swimmers in Jordan. Through a survey distributed to the Jordanian Swimming Federation’s registered swimmers, 173 participants (72 female, 101 male) aged 18 to 25 completed the questionnaire. The results of the study showed that the most common injuries were arranged as follows: muscle spasms, muscle cramps, and sprains; 29.8%, 28.6%, and 17.7%, respectively. The most vulnerable areas were the Shoulder 35.3%, followed by the back 14.4 %, the knee 10.7%, and the neck 10.2%. The most common cause of injuries was Inadequate warm-up, where his percentage reached 34%, followed by Overtraining with a percentage of 27%. Reduced training intensity or frequency, impaired stroke technique, limited range of motion or flexibility, and required complete cessation of swimming had the main effectiveness of the swimming performance and training, where the percent was 34.9%, 20.8%,10.3%, and 4.3%, respectively.
{"title":"Comprehensive Study on Musculoskeletal Injuries among Swimmers in Jordan: Causes, Effects, and Prevention Strategies","authors":"","doi":"10.34104/ejmhs.024.020029","DOIUrl":"https://doi.org/10.34104/ejmhs.024.020029","url":null,"abstract":"No prior investigations have evaluated the musculoskeletal (MSK) injuries characteristic of swimming sport in Jordan. This study aimed to identify the most common sports injuries among male and female swimmers in Jordan. Through a survey distributed to the Jordanian Swimming Federation’s registered swimmers, 173 participants (72 female, 101 male) aged 18 to 25 completed the questionnaire. The results of the study showed that the most common injuries were arranged as follows: muscle spasms, muscle cramps, and sprains; 29.8%, 28.6%, and 17.7%, respectively. The most vulnerable areas were the Shoulder 35.3%, followed by the back 14.4 %, the knee 10.7%, and the neck 10.2%. The most common cause of injuries was Inadequate warm-up, where his percentage reached 34%, followed by Overtraining with a percentage of 27%. Reduced training intensity or frequency, impaired stroke technique, limited range of motion or flexibility, and required complete cessation of swimming had the main effectiveness of the swimming performance and training, where the percent was 34.9%, 20.8%,10.3%, and 4.3%, respectively.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139773941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.24018/ejmed.2024.6.1.1996
Noeme Henriques Freitas, Cinthia Cristina Matheus Xerez Albuquerque, Mariana Pereira Lima, N. A. Fraiji, Marilda de Souza Gonçalves, J. P. M. Moura Neto
Introduction: Patients with acute myeloid leukemia (AML) show a higher risk for several types of infections, including fungal infections (FI), which are one of the main causes of morbidity and mortality. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme located in all cells that is very necessary in leukocytes for the production of basic and acid proteases that are used to destroy invading microorganisms. Our objective in this study was to evaluate whether polymorphisms in the G6PD gene concomitantly with FI are associated with clinical events and morbidity in patients diagnosed with AML and followed up at the Amazonas State Blood Center (HEMOAM), Manaus, Brazil. Materials and Methods: The study population was randomly constituted of adults and children, of either sex, and any age, with a diagnosis of acute myeloid leukemia, all of whom were undergoing treatment at the HEMOAM. Molecular genotyping was performed using real-time PCR (qPCR) and subsequent Sanger sequencing to confirm the c.202G > A/c.376A > G polymorphisms. Results: A total of 157 patients (91 (58%) males and 66 (42%) females) were involved in the study. The most prevalent AML subtype in the studied group was M3 in 63 patients (40.12%), followed by M5 in 33 patients (21.02%), M2 in 21 patients (13.37%) and M4 in 15 patients (9.55%), with a similar prevalence between genders. The prevalence of fungal infections was identical between genders; however, bruising (p = 0.004), vomiting (p = 0.016) and cardiac alterations (p < 0.001) were higher in females, while persistent cough (p = 0.049) and diarrhea (p < 0.001) were higher in males. A total of eighteen patients presents G6PD polymorphisms, with 8 (5.1%) of these for c.202GA/AA, 18 (11.5%) for c.376AG/GG and 4 (2.5%) for both polymorphisms concomitantly (c.202AA/c.376GG). However, the prevalence of death in patients affected with FI was much higher in those that have these polymorphisms (p < 0.001). Conclusion: We believe that the determination of G6PD polymorphisms will allow the development of monitoring strategies, and aid in early diagnosis and the appropriate and targeted treatment for AML. In addition, evaluating their activity may help to identify AML patients at a higher risk of FI, thus allowing the design of more intensive therapeutic and surveillance strategies.
简介急性髓性白血病（AML）患者感染多种类型感染的风险较高，其中真菌感染（FI）是发病和死亡的主要原因之一。葡萄糖-6-磷酸脱氢酶（G6PD）是一种存在于所有细胞中的酶，是白细胞产生碱性和酸性蛋白酶所必需的，这些蛋白酶用于消灭入侵的微生物。本研究的目的是评估 G6PD 基因多态性与 FI 是否同时与巴西玛瑙斯亚马孙州血液中心（HEMOAM）随访的确诊急性髓细胞白血病患者的临床事件和发病率有关：研究对象为被诊断为急性髓性白血病并在亚马孙州血液中心（HEMOAM）接受治疗的成人和儿童，性别不限，年龄不限。使用实时 PCR（qPCR）进行分子基因分型，随后进行 Sanger 测序以确认 c.202G > A/c.376A > G 多态性：研究共涉及 157 名患者（男性 91 人（58%），女性 66 人（42%））。研究组中最常见的急性髓细胞性白血病亚型是M3型，有63名患者（40.12%），其次是M5型，有33名患者（21.02%），M2型有21名患者（13.37%），M4型有15名患者（9.55%），男女发病率相似。真菌感染的男女发病率相同；但女性出现瘀斑（p = 0.004）、呕吐（p = 0.016）和心脏改变（p < 0.001）的比例较高，而男性出现持续咳嗽（p = 0.049）和腹泻（p < 0.001）的比例较高。共有18名患者出现G6PD多态性，其中8人（5.1%）为c.202GA/AA，18人（11.5%）为c.376AG/GG，4人（2.5%）同时出现两种多态性（c.202AA/c.376GG）。然而，具有这些多态性的 FI 患者的死亡发生率要高得多（p < 0.001）：我们相信，G6PD 多态性的确定将有助于制定监测策略，并有助于急性髓细胞性白血病的早期诊断和有针对性的适当治疗。此外，评估 G6PD 多态性的活性还有助于识别 FI 风险较高的急性髓细胞性白血病患者，从而制定更深入的治疗和监测策略。
{"title":"c.202G > A/c.376A > G G6PD Polymorphisms Increase the Risk of Fungal Infections in Acute Myeloid Leukemia Patients","authors":"Noeme Henriques Freitas, Cinthia Cristina Matheus Xerez Albuquerque, Mariana Pereira Lima, N. A. Fraiji, Marilda de Souza Gonçalves, J. P. M. Moura Neto","doi":"10.24018/ejmed.2024.6.1.1996","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.1996","url":null,"abstract":"Introduction: Patients with acute myeloid leukemia (AML) show a higher risk for several types of infections, including fungal infections (FI), which are one of the main causes of morbidity and mortality. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme located in all cells that is very necessary in leukocytes for the production of basic and acid proteases that are used to destroy invading microorganisms. Our objective in this study was to evaluate whether polymorphisms in the G6PD gene concomitantly with FI are associated with clinical events and morbidity in patients diagnosed with AML and followed up at the Amazonas State Blood Center (HEMOAM), Manaus, Brazil.\u0000Materials and Methods: The study population was randomly constituted of adults and children, of either sex, and any age, with a diagnosis of acute myeloid leukemia, all of whom were undergoing treatment at the HEMOAM. Molecular genotyping was performed using real-time PCR (qPCR) and subsequent Sanger sequencing to confirm the c.202G > A/c.376A > G polymorphisms.\u0000Results: A total of 157 patients (91 (58%) males and 66 (42%) females) were involved in the study. The most prevalent AML subtype in the studied group was M3 in 63 patients (40.12%), followed by M5 in 33 patients (21.02%), M2 in 21 patients (13.37%) and M4 in 15 patients (9.55%), with a similar prevalence between genders. The prevalence of fungal infections was identical between genders; however, bruising (p = 0.004), vomiting (p = 0.016) and cardiac alterations (p < 0.001) were higher in females, while persistent cough (p = 0.049) and diarrhea (p < 0.001) were higher in males. A total of eighteen patients presents G6PD polymorphisms, with 8 (5.1%) of these for c.202GA/AA, 18 (11.5%) for c.376AG/GG and 4 (2.5%) for both polymorphisms concomitantly (c.202AA/c.376GG). However, the prevalence of death in patients affected with FI was much higher in those that have these polymorphisms (p < 0.001).\u0000Conclusion: We believe that the determination of G6PD polymorphisms will allow the development of monitoring strategies, and aid in early diagnosis and the appropriate and targeted treatment for AML. In addition, evaluating their activity may help to identify AML patients at a higher risk of FI, thus allowing the design of more intensive therapeutic and surveillance strategies.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"55 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.24018/ejmed.2024.6.1.1998
Mohammad Saleh Sadeghi, Negar Vakili Razlighi, Hadi Vakili Razlighi
Background: Shivering is one of the most common problems after spinal anesthesia, which can cause many complications. Various methods and drugs have been used to prevent and treat postoperative shivering. In the present study, the pretreatment effect of ondansetron and dexamethasone in reducing the incidence of shivering after elective caesarean section by the spinal method has been investigated. Methods: In this study, 78 patients undergoing elective cesarean surgery who were eligible to enter the study were evaluated and randomly divided into two groups: 8mg of ondansetron and 4mg of dexamethasone 15 minutes before the end of surgery. Then, the incidence of shivering was measured at specific time intervals after surgery. Statistical analysis was done using SPSS software. Results: The two groups were similar in terms of age, height, weight, and BMI (p-value > 0.05). The incidence of shivering at the time of entering the recovery, 10, 20, and 30 minutes in the ondansetron group was 23.1%, 20.5%, 12.8% and 0% and in the dexamethasone, group was 20.5%, 15.4%, 5.2% and 0%, respectively. Statistical analysis showed that these differences are not significant at the significance level of 0.05. These two drugs have the same effectiveness in controlling shivering after cesarean section under spinal anesthesia (p-value > 0.05). Conclusion: Dexamethasone and ondansetron will be able to control shivering after caesarean section with spinal anesthesia.
{"title":"Comparison of the Effect of Ondansetron and Dexamethasone on Postoperative Shivering After Cesarean Section in Patients Undergoing Spinal Anesthesia","authors":"Mohammad Saleh Sadeghi, Negar Vakili Razlighi, Hadi Vakili Razlighi","doi":"10.24018/ejmed.2024.6.1.1998","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.1998","url":null,"abstract":"Background: Shivering is one of the most common problems after spinal anesthesia, which can cause many complications. Various methods and drugs have been used to prevent and treat postoperative shivering. In the present study, the pretreatment effect of ondansetron and dexamethasone in reducing the incidence of shivering after elective caesarean section by the spinal method has been investigated.\u0000Methods: In this study, 78 patients undergoing elective cesarean surgery who were eligible to enter the study were evaluated and randomly divided into two groups: 8mg of ondansetron and 4mg of dexamethasone 15 minutes before the end of surgery. Then, the incidence of shivering was measured at specific time intervals after surgery. Statistical analysis was done using SPSS software.\u0000Results: The two groups were similar in terms of age, height, weight, and BMI (p-value > 0.05). The incidence of shivering at the time of entering the recovery, 10, 20, and 30 minutes in the ondansetron group was 23.1%, 20.5%, 12.8% and 0% and in the dexamethasone, group was 20.5%, 15.4%, 5.2% and 0%, respectively. Statistical analysis showed that these differences are not significant at the significance level of 0.05. These two drugs have the same effectiveness in controlling shivering after cesarean section under spinal anesthesia (p-value > 0.05).\u0000Conclusion: Dexamethasone and ondansetron will be able to control shivering after caesarean section with spinal anesthesia.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.24018/ejmed.2024.6.1.1996
Noeme Henriques Freitas, Cinthia Cristina Matheus Xerez Albuquerque, Mariana Pereira Lima, N. A. Fraiji, Marilda de Souza Gonçalves, J. P. M. Moura Neto
Introduction: Patients with acute myeloid leukemia (AML) show a higher risk for several types of infections, including fungal infections (FI), which are one of the main causes of morbidity and mortality. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme located in all cells that is very necessary in leukocytes for the production of basic and acid proteases that are used to destroy invading microorganisms. Our objective in this study was to evaluate whether polymorphisms in the G6PD gene concomitantly with FI are associated with clinical events and morbidity in patients diagnosed with AML and followed up at the Amazonas State Blood Center (HEMOAM), Manaus, Brazil. Materials and Methods: The study population was randomly constituted of adults and children, of either sex, and any age, with a diagnosis of acute myeloid leukemia, all of whom were undergoing treatment at the HEMOAM. Molecular genotyping was performed using real-time PCR (qPCR) and subsequent Sanger sequencing to confirm the c.202G > A/c.376A > G polymorphisms. Results: A total of 157 patients (91 (58%) males and 66 (42%) females) were involved in the study. The most prevalent AML subtype in the studied group was M3 in 63 patients (40.12%), followed by M5 in 33 patients (21.02%), M2 in 21 patients (13.37%) and M4 in 15 patients (9.55%), with a similar prevalence between genders. The prevalence of fungal infections was identical between genders; however, bruising (p = 0.004), vomiting (p = 0.016) and cardiac alterations (p < 0.001) were higher in females, while persistent cough (p = 0.049) and diarrhea (p < 0.001) were higher in males. A total of eighteen patients presents G6PD polymorphisms, with 8 (5.1%) of these for c.202GA/AA, 18 (11.5%) for c.376AG/GG and 4 (2.5%) for both polymorphisms concomitantly (c.202AA/c.376GG). However, the prevalence of death in patients affected with FI was much higher in those that have these polymorphisms (p < 0.001). Conclusion: We believe that the determination of G6PD polymorphisms will allow the development of monitoring strategies, and aid in early diagnosis and the appropriate and targeted treatment for AML. In addition, evaluating their activity may help to identify AML patients at a higher risk of FI, thus allowing the design of more intensive therapeutic and surveillance strategies.
简介急性髓性白血病（AML）患者感染多种类型感染的风险较高，其中真菌感染（FI）是发病和死亡的主要原因之一。葡萄糖-6-磷酸脱氢酶（G6PD）是一种存在于所有细胞中的酶，是白细胞产生碱性和酸性蛋白酶所必需的，这些蛋白酶用于消灭入侵的微生物。本研究的目的是评估 G6PD 基因多态性与 FI 是否同时与巴西玛瑙斯亚马孙州血液中心（HEMOAM）随访的确诊急性髓细胞白血病患者的临床事件和发病率有关：研究对象为被诊断为急性髓性白血病并在亚马孙州血液中心（HEMOAM）接受治疗的成人和儿童，性别不限，年龄不限。使用实时 PCR（qPCR）进行分子基因分型，随后进行 Sanger 测序以确认 c.202G > A/c.376A > G 多态性：研究共涉及 157 名患者（男性 91 人（58%），女性 66 人（42%））。研究组中最常见的急性髓细胞性白血病亚型是M3型，有63名患者（40.12%），其次是M5型，有33名患者（21.02%），M2型有21名患者（13.37%），M4型有15名患者（9.55%），男女发病率相似。真菌感染的男女发病率相同；但女性出现瘀斑（p = 0.004）、呕吐（p = 0.016）和心脏改变（p < 0.001）的比例较高，而男性出现持续咳嗽（p = 0.049）和腹泻（p < 0.001）的比例较高。共有18名患者出现G6PD多态性，其中8人（5.1%）为c.202GA/AA，18人（11.5%）为c.376AG/GG，4人（2.5%）同时出现两种多态性（c.202AA/c.376GG）。然而，具有这些多态性的 FI 患者的死亡发生率要高得多（p < 0.001）：我们相信，G6PD 多态性的确定将有助于制定监测策略，并有助于急性髓细胞性白血病的早期诊断和有针对性的适当治疗。此外，评估 G6PD 多态性的活性还有助于识别 FI 风险较高的急性髓细胞性白血病患者，从而制定更深入的治疗和监测策略。
{"title":"c.202G > A/c.376A > G G6PD Polymorphisms Increase the Risk of Fungal Infections in Acute Myeloid Leukemia Patients","authors":"Noeme Henriques Freitas, Cinthia Cristina Matheus Xerez Albuquerque, Mariana Pereira Lima, N. A. Fraiji, Marilda de Souza Gonçalves, J. P. M. Moura Neto","doi":"10.24018/ejmed.2024.6.1.1996","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.1996","url":null,"abstract":"Introduction: Patients with acute myeloid leukemia (AML) show a higher risk for several types of infections, including fungal infections (FI), which are one of the main causes of morbidity and mortality. Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme located in all cells that is very necessary in leukocytes for the production of basic and acid proteases that are used to destroy invading microorganisms. Our objective in this study was to evaluate whether polymorphisms in the G6PD gene concomitantly with FI are associated with clinical events and morbidity in patients diagnosed with AML and followed up at the Amazonas State Blood Center (HEMOAM), Manaus, Brazil.\u0000Materials and Methods: The study population was randomly constituted of adults and children, of either sex, and any age, with a diagnosis of acute myeloid leukemia, all of whom were undergoing treatment at the HEMOAM. Molecular genotyping was performed using real-time PCR (qPCR) and subsequent Sanger sequencing to confirm the c.202G > A/c.376A > G polymorphisms.\u0000Results: A total of 157 patients (91 (58%) males and 66 (42%) females) were involved in the study. The most prevalent AML subtype in the studied group was M3 in 63 patients (40.12%), followed by M5 in 33 patients (21.02%), M2 in 21 patients (13.37%) and M4 in 15 patients (9.55%), with a similar prevalence between genders. The prevalence of fungal infections was identical between genders; however, bruising (p = 0.004), vomiting (p = 0.016) and cardiac alterations (p < 0.001) were higher in females, while persistent cough (p = 0.049) and diarrhea (p < 0.001) were higher in males. A total of eighteen patients presents G6PD polymorphisms, with 8 (5.1%) of these for c.202GA/AA, 18 (11.5%) for c.376AG/GG and 4 (2.5%) for both polymorphisms concomitantly (c.202AA/c.376GG). However, the prevalence of death in patients affected with FI was much higher in those that have these polymorphisms (p < 0.001).\u0000Conclusion: We believe that the determination of G6PD polymorphisms will allow the development of monitoring strategies, and aid in early diagnosis and the appropriate and targeted treatment for AML. In addition, evaluating their activity may help to identify AML patients at a higher risk of FI, thus allowing the design of more intensive therapeutic and surveillance strategies.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"22 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.24018/ejmed.2024.6.1.1998
Mohammad Saleh Sadeghi, Negar Vakili Razlighi, Hadi Vakili Razlighi
Background: Shivering is one of the most common problems after spinal anesthesia, which can cause many complications. Various methods and drugs have been used to prevent and treat postoperative shivering. In the present study, the pretreatment effect of ondansetron and dexamethasone in reducing the incidence of shivering after elective caesarean section by the spinal method has been investigated. Methods: In this study, 78 patients undergoing elective cesarean surgery who were eligible to enter the study were evaluated and randomly divided into two groups: 8mg of ondansetron and 4mg of dexamethasone 15 minutes before the end of surgery. Then, the incidence of shivering was measured at specific time intervals after surgery. Statistical analysis was done using SPSS software. Results: The two groups were similar in terms of age, height, weight, and BMI (p-value > 0.05). The incidence of shivering at the time of entering the recovery, 10, 20, and 30 minutes in the ondansetron group was 23.1%, 20.5%, 12.8% and 0% and in the dexamethasone, group was 20.5%, 15.4%, 5.2% and 0%, respectively. Statistical analysis showed that these differences are not significant at the significance level of 0.05. These two drugs have the same effectiveness in controlling shivering after cesarean section under spinal anesthesia (p-value > 0.05). Conclusion: Dexamethasone and ondansetron will be able to control shivering after caesarean section with spinal anesthesia.
{"title":"Comparison of the Effect of Ondansetron and Dexamethasone on Postoperative Shivering After Cesarean Section in Patients Undergoing Spinal Anesthesia","authors":"Mohammad Saleh Sadeghi, Negar Vakili Razlighi, Hadi Vakili Razlighi","doi":"10.24018/ejmed.2024.6.1.1998","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.1998","url":null,"abstract":"Background: Shivering is one of the most common problems after spinal anesthesia, which can cause many complications. Various methods and drugs have been used to prevent and treat postoperative shivering. In the present study, the pretreatment effect of ondansetron and dexamethasone in reducing the incidence of shivering after elective caesarean section by the spinal method has been investigated.\u0000Methods: In this study, 78 patients undergoing elective cesarean surgery who were eligible to enter the study were evaluated and randomly divided into two groups: 8mg of ondansetron and 4mg of dexamethasone 15 minutes before the end of surgery. Then, the incidence of shivering was measured at specific time intervals after surgery. Statistical analysis was done using SPSS software.\u0000Results: The two groups were similar in terms of age, height, weight, and BMI (p-value > 0.05). The incidence of shivering at the time of entering the recovery, 10, 20, and 30 minutes in the ondansetron group was 23.1%, 20.5%, 12.8% and 0% and in the dexamethasone, group was 20.5%, 15.4%, 5.2% and 0%, respectively. Statistical analysis showed that these differences are not significant at the significance level of 0.05. These two drugs have the same effectiveness in controlling shivering after cesarean section under spinal anesthesia (p-value > 0.05).\u0000Conclusion: Dexamethasone and ondansetron will be able to control shivering after caesarean section with spinal anesthesia.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"320 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09DOI: 10.24018/ejmed.2024.6.1.2022
Brian Shaw, Norah Mubarak, Mustafa Nuaimi, Cosette Persall, Thomas Vollenweider, Ryan Shaw, Mario Madruga, S. Carlan
Background: Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome containing the BCR-ABL protein with deregulated tyrosine kinase activity. Tyrosine kinase inhibitors (TKIs) were developed to target this oncogene. Dasatinib, a TKI, has rarely been associated with spontaneous chylothorax. The majority occur within 1 year of dasatinib initiation and resolve after drug cessation. In contrast, we present a patient with CML on dasatinib therapy for 8 years who developed recurrent unilateral chylothorax even after cessation of dasatinib. Case: A 57-year-old male with a history of CML on dasatinib therapy presented to the hospital for nausea and vomiting. A computed tomographic scan revealed a large right-sided pleural effusion with thoracentesis yielding 1.5 liters of chylous fluid. The patient’s hospital course was complicated by intracranial hemorrhage and subsequent admission to the intensive care unit. Dasatinib was stopped during this time. The patient experienced multiple recurrences of this effusion with significant output via thoracentesis and chest tube despite dietary changes. Lymphangiography was performed but revealed no evidence of thoracic duct leakage. Conclusions: Chylothorax from dasatinib is rare, usually occurs within 1 to 2 years of treatment onset, and resolves with discontinuation. However as supported by this case and others, it may occur as late as 8 years from treatment onset and chylothorax may continually re-accumulate or persist up to 1 year from dasatinib cessation. It is imperative to rule out underlying thoracic duct disruption prior to attributing etiology to dasatinib as a misdiagnosis may result in treatment delays.
{"title":"A Rare Case of Recurrent Dasatinib-Induced Chylothorax Years After Initial Treatment","authors":"Brian Shaw, Norah Mubarak, Mustafa Nuaimi, Cosette Persall, Thomas Vollenweider, Ryan Shaw, Mario Madruga, S. Carlan","doi":"10.24018/ejmed.2024.6.1.2022","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2022","url":null,"abstract":"Background: Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome containing the BCR-ABL protein with deregulated tyrosine kinase activity. Tyrosine kinase inhibitors (TKIs) were developed to target this oncogene. Dasatinib, a TKI, has rarely been associated with spontaneous chylothorax. The majority occur within 1 year of dasatinib initiation and resolve after drug cessation. In contrast, we present a patient with CML on dasatinib therapy for 8 years who developed recurrent unilateral chylothorax even after cessation of dasatinib.\u0000Case: A 57-year-old male with a history of CML on dasatinib therapy presented to the hospital for nausea and vomiting. A computed tomographic scan revealed a large right-sided pleural effusion with thoracentesis yielding 1.5 liters of chylous fluid. The patient’s hospital course was complicated by intracranial hemorrhage and subsequent admission to the intensive care unit. Dasatinib was stopped during this time. The patient experienced multiple recurrences of this effusion with significant output via thoracentesis and chest tube despite dietary changes. Lymphangiography was performed but revealed no evidence of thoracic duct leakage.\u0000Conclusions: Chylothorax from dasatinib is rare, usually occurs within 1 to 2 years of treatment onset, and resolves with discontinuation. However as supported by this case and others, it may occur as late as 8 years from treatment onset and chylothorax may continually re-accumulate or persist up to 1 year from dasatinib cessation. It is imperative to rule out underlying thoracic duct disruption prior to attributing etiology to dasatinib as a misdiagnosis may result in treatment delays.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":" 62","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09DOI: 10.34104/ejmhs.024.013019
Pre-eclampsia (PE) is a multifactorial disorder that ultimately manifests as hypertension in the pregnant woman. This study was aimed at determining socio-demographic characteristics of PE among pregnant women attending tertiary Hospitals in Yenagoa, Bayelsa State, Nigeria. A total of 182 pregnant women, consisting of 91 women with PE (gestation > 20 weeks, blood pressure ≥ 140/90 mmHg) and 91 normotensive pregnant women at gestation > 20 weeks were enrolled in the study by consent. These respondents filled out structured questionnaires that obtained data on sociodemographic variables (which are maternal age, parity, body mass index [BMI], systolic and diastolic blood pressure [SBP and DBP], educational level, family history of PE, occupation, the severity of PE, primipaternity, and gestational age of PE. Data was grouped into PE cases and control. Chi-square was used to determine associations between PE and sociodemographic variables for categorical data, whereas the independent T-test was used to determine differences between groups for parametric data. Data was considered significant at p < .05. Results showed that BMI (X^2 = 21.01, p = .00), SBP (T = 27.06, p = 0.00), DBP (T = 29.75, p = 0.00), educational level (X^2 = 14.15,p = .00), family history of pre-eclampsia (X^2 = 33.09,p = .00), and primipaternity (X^2 = 21.01,p= .00) showed significant associations with pre-eclampsia (p < .05). It is recommended that healthy weight management, blood pressure monitoring, adequate antenatal care, and family history counselling be promoted in health facilities in our setting.
{"title":"Socio-demographic Characteristics of a Cross-section of Pre-eclamptic Women in Yenagoa, Nigeria","authors":"","doi":"10.34104/ejmhs.024.013019","DOIUrl":"https://doi.org/10.34104/ejmhs.024.013019","url":null,"abstract":"Pre-eclampsia (PE) is a multifactorial disorder that ultimately manifests as hypertension in the pregnant woman. This study was aimed at determining socio-demographic characteristics of PE among pregnant women attending tertiary Hospitals in Yenagoa, Bayelsa State, Nigeria. A total of 182 pregnant women, consisting of 91 women with PE (gestation > 20 weeks, blood pressure ≥ 140/90 mmHg) and 91 normotensive pregnant women at gestation > 20 weeks were enrolled in the study by consent. These respondents filled out structured questionnaires that obtained data on sociodemographic variables (which are maternal age, parity, body mass index [BMI], systolic and diastolic blood pressure [SBP and DBP], educational level, family history of PE, occupation, the severity of PE, primipaternity, and gestational age of PE. Data was grouped into PE cases and control. Chi-square was used to determine associations between PE and sociodemographic variables for categorical data, whereas the independent T-test was used to determine differences between groups for parametric data. Data was considered significant at p < .05. Results showed that BMI (X^2 = 21.01, p = .00), SBP (T = 27.06, p = 0.00), DBP (T = 29.75, p = 0.00), educational level (X^2 = 14.15,p = .00), family history of pre-eclampsia (X^2 = 33.09,p = .00), and primipaternity (X^2 = 21.01,p= .00) showed significant associations with pre-eclampsia (p < .05). It is recommended that healthy weight management, blood pressure monitoring, adequate antenatal care, and family history counselling be promoted in health facilities in our setting.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"160 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to explore the workplace safety experiences of health workers (doctors and nurses) at a tertiary hospital in Bangladesh. Materials and Methods: This was a descriptive cross-sectional study among conveniently selected 305 registered physicians and nurses working in the designated tertiary hospital. After obtaining the written informed consent, data was collected using face-to-face interviews with a pre-tested, semistructured, interviewer-administered questionnaire from December 2021 to January 2022. Frequency and proportion described the variables. Result: The mean age of the participants was 28.8 years. Female individuals constituted the majority, accounting for 69.2% of the total. Approximately 69.8% of individuals reported experiencing occupational health hazards. Psychological hazards were the most frequently reported (56.1%), followed by workplace-acquired health hazards (15.7%) and physical hazards (13.8%) among all participants. While 79.0% of the participants were aware of workplace health and safety, only 7.9% received safety training, and only 7.5% reported any occupational hazard to the hospital management. Conclusion: Healthcare personnel adjust to several professional hazards in a complicated series of events, as the study shows. The complexity of the healthcare environment poses considerable psychological and health hazards. Although there is good preparedness and procedure awareness, the analysis shows some crucial resources and training still need to be improved. Therefore, some strategic actions are needed to improve healthcare professionals’ safety and well-being in the modern healthcare environment through crucial resources and training.
{"title":"Occupational Health Hazard Experiences of Doctors and Nurses at a Tertiary Hospital in Bangladesh","authors":"Adiba Sharmin Sikder, Azizur Rahman Sharaque, Naila Haque, Marzan Sultana, Irfan Nowrose Noor, Ummul Khair Alam, Sathi Dastider","doi":"10.24018/ejmed.2024.6.1.2021","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2021","url":null,"abstract":"Objective: This study aimed to explore the workplace safety experiences of health workers (doctors and nurses) at a tertiary hospital in Bangladesh.\u0000Materials and Methods: This was a descriptive cross-sectional study among conveniently selected 305 registered physicians and nurses working in the designated tertiary hospital. After obtaining the written informed consent, data was collected using face-to-face interviews with a pre-tested, semistructured, interviewer-administered questionnaire from December 2021 to January 2022. Frequency and proportion described the variables.\u0000Result: The mean age of the participants was 28.8 years. Female individuals constituted the majority, accounting for 69.2% of the total. Approximately 69.8% of individuals reported experiencing occupational health hazards. Psychological hazards were the most frequently reported (56.1%), followed by workplace-acquired health hazards (15.7%) and physical hazards (13.8%) among all participants. While 79.0% of the participants were aware of workplace health and safety, only 7.9% received safety training, and only 7.5% reported any occupational hazard to the hospital management.\u0000Conclusion: Healthcare personnel adjust to several professional hazards in a complicated series of events, as the study shows. The complexity of the healthcare environment poses considerable psychological and health hazards. Although there is good preparedness and procedure awareness, the analysis shows some crucial resources and training still need to be improved. Therefore, some strategic actions are needed to improve healthcare professionals’ safety and well-being in the modern healthcare environment through crucial resources and training.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"71 11-12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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