Pub Date : 2024-02-09DOI: 10.34104/ejmhs.024.013019
Pre-eclampsia (PE) is a multifactorial disorder that ultimately manifests as hypertension in the pregnant woman. This study was aimed at determining socio-demographic characteristics of PE among pregnant women attending tertiary Hospitals in Yenagoa, Bayelsa State, Nigeria. A total of 182 pregnant women, consisting of 91 women with PE (gestation > 20 weeks, blood pressure ≥ 140/90 mmHg) and 91 normotensive pregnant women at gestation > 20 weeks were enrolled in the study by consent. These respondents filled out structured questionnaires that obtained data on sociodemographic variables (which are maternal age, parity, body mass index [BMI], systolic and diastolic blood pressure [SBP and DBP], educational level, family history of PE, occupation, the severity of PE, primipaternity, and gestational age of PE. Data was grouped into PE cases and control. Chi-square was used to determine associations between PE and sociodemographic variables for categorical data, whereas the independent T-test was used to determine differences between groups for parametric data. Data was considered significant at p < .05. Results showed that BMI (X^2 = 21.01, p = .00), SBP (T = 27.06, p = 0.00), DBP (T = 29.75, p = 0.00), educational level (X^2 = 14.15,p = .00), family history of pre-eclampsia (X^2 = 33.09,p = .00), and primipaternity (X^2 = 21.01,p= .00) showed significant associations with pre-eclampsia (p < .05). It is recommended that healthy weight management, blood pressure monitoring, adequate antenatal care, and family history counselling be promoted in health facilities in our setting.
{"title":"Socio-demographic Characteristics of a Cross-section of Pre-eclamptic Women in Yenagoa, Nigeria","authors":"","doi":"10.34104/ejmhs.024.013019","DOIUrl":"https://doi.org/10.34104/ejmhs.024.013019","url":null,"abstract":"Pre-eclampsia (PE) is a multifactorial disorder that ultimately manifests as hypertension in the pregnant woman. This study was aimed at determining socio-demographic characteristics of PE among pregnant women attending tertiary Hospitals in Yenagoa, Bayelsa State, Nigeria. A total of 182 pregnant women, consisting of 91 women with PE (gestation > 20 weeks, blood pressure ≥ 140/90 mmHg) and 91 normotensive pregnant women at gestation > 20 weeks were enrolled in the study by consent. These respondents filled out structured questionnaires that obtained data on sociodemographic variables (which are maternal age, parity, body mass index [BMI], systolic and diastolic blood pressure [SBP and DBP], educational level, family history of PE, occupation, the severity of PE, primipaternity, and gestational age of PE. Data was grouped into PE cases and control. Chi-square was used to determine associations between PE and sociodemographic variables for categorical data, whereas the independent T-test was used to determine differences between groups for parametric data. Data was considered significant at p < .05. Results showed that BMI (X^2 = 21.01, p = .00), SBP (T = 27.06, p = 0.00), DBP (T = 29.75, p = 0.00), educational level (X^2 = 14.15,p = .00), family history of pre-eclampsia (X^2 = 33.09,p = .00), and primipaternity (X^2 = 21.01,p= .00) showed significant associations with pre-eclampsia (p < .05). It is recommended that healthy weight management, blood pressure monitoring, adequate antenatal care, and family history counselling be promoted in health facilities in our setting.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":" 102","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to explore the workplace safety experiences of health workers (doctors and nurses) at a tertiary hospital in Bangladesh. Materials and Methods: This was a descriptive cross-sectional study among conveniently selected 305 registered physicians and nurses working in the designated tertiary hospital. After obtaining the written informed consent, data was collected using face-to-face interviews with a pre-tested, semistructured, interviewer-administered questionnaire from December 2021 to January 2022. Frequency and proportion described the variables. Result: The mean age of the participants was 28.8 years. Female individuals constituted the majority, accounting for 69.2% of the total. Approximately 69.8% of individuals reported experiencing occupational health hazards. Psychological hazards were the most frequently reported (56.1%), followed by workplace-acquired health hazards (15.7%) and physical hazards (13.8%) among all participants. While 79.0% of the participants were aware of workplace health and safety, only 7.9% received safety training, and only 7.5% reported any occupational hazard to the hospital management. Conclusion: Healthcare personnel adjust to several professional hazards in a complicated series of events, as the study shows. The complexity of the healthcare environment poses considerable psychological and health hazards. Although there is good preparedness and procedure awareness, the analysis shows some crucial resources and training still need to be improved. Therefore, some strategic actions are needed to improve healthcare professionals’ safety and well-being in the modern healthcare environment through crucial resources and training.
{"title":"Occupational Health Hazard Experiences of Doctors and Nurses at a Tertiary Hospital in Bangladesh","authors":"Adiba Sharmin Sikder, Azizur Rahman Sharaque, Naila Haque, Marzan Sultana, Irfan Nowrose Noor, Ummul Khair Alam, Sathi Dastider","doi":"10.24018/ejmed.2024.6.1.2021","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2021","url":null,"abstract":"Objective: This study aimed to explore the workplace safety experiences of health workers (doctors and nurses) at a tertiary hospital in Bangladesh.\u0000Materials and Methods: This was a descriptive cross-sectional study among conveniently selected 305 registered physicians and nurses working in the designated tertiary hospital. After obtaining the written informed consent, data was collected using face-to-face interviews with a pre-tested, semistructured, interviewer-administered questionnaire from December 2021 to January 2022. Frequency and proportion described the variables.\u0000Result: The mean age of the participants was 28.8 years. Female individuals constituted the majority, accounting for 69.2% of the total. Approximately 69.8% of individuals reported experiencing occupational health hazards. Psychological hazards were the most frequently reported (56.1%), followed by workplace-acquired health hazards (15.7%) and physical hazards (13.8%) among all participants. While 79.0% of the participants were aware of workplace health and safety, only 7.9% received safety training, and only 7.5% reported any occupational hazard to the hospital management.\u0000Conclusion: Healthcare personnel adjust to several professional hazards in a complicated series of events, as the study shows. The complexity of the healthcare environment poses considerable psychological and health hazards. Although there is good preparedness and procedure awareness, the analysis shows some crucial resources and training still need to be improved. Therefore, some strategic actions are needed to improve healthcare professionals’ safety and well-being in the modern healthcare environment through crucial resources and training.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09DOI: 10.24018/ejmed.2024.6.1.2022
Brian Shaw, Norah Mubarak, Mustafa Nuaimi, Cosette Persall, Thomas Vollenweider, Ryan Shaw, Mario Madruga, S. Carlan
Background: Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome containing the BCR-ABL protein with deregulated tyrosine kinase activity. Tyrosine kinase inhibitors (TKIs) were developed to target this oncogene. Dasatinib, a TKI, has rarely been associated with spontaneous chylothorax. The majority occur within 1 year of dasatinib initiation and resolve after drug cessation. In contrast, we present a patient with CML on dasatinib therapy for 8 years who developed recurrent unilateral chylothorax even after cessation of dasatinib. Case: A 57-year-old male with a history of CML on dasatinib therapy presented to the hospital for nausea and vomiting. A computed tomographic scan revealed a large right-sided pleural effusion with thoracentesis yielding 1.5 liters of chylous fluid. The patient’s hospital course was complicated by intracranial hemorrhage and subsequent admission to the intensive care unit. Dasatinib was stopped during this time. The patient experienced multiple recurrences of this effusion with significant output via thoracentesis and chest tube despite dietary changes. Lymphangiography was performed but revealed no evidence of thoracic duct leakage. Conclusions: Chylothorax from dasatinib is rare, usually occurs within 1 to 2 years of treatment onset, and resolves with discontinuation. However as supported by this case and others, it may occur as late as 8 years from treatment onset and chylothorax may continually re-accumulate or persist up to 1 year from dasatinib cessation. It is imperative to rule out underlying thoracic duct disruption prior to attributing etiology to dasatinib as a misdiagnosis may result in treatment delays.
{"title":"A Rare Case of Recurrent Dasatinib-Induced Chylothorax Years After Initial Treatment","authors":"Brian Shaw, Norah Mubarak, Mustafa Nuaimi, Cosette Persall, Thomas Vollenweider, Ryan Shaw, Mario Madruga, S. Carlan","doi":"10.24018/ejmed.2024.6.1.2022","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2022","url":null,"abstract":"Background: Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome containing the BCR-ABL protein with deregulated tyrosine kinase activity. Tyrosine kinase inhibitors (TKIs) were developed to target this oncogene. Dasatinib, a TKI, has rarely been associated with spontaneous chylothorax. The majority occur within 1 year of dasatinib initiation and resolve after drug cessation. In contrast, we present a patient with CML on dasatinib therapy for 8 years who developed recurrent unilateral chylothorax even after cessation of dasatinib.\u0000Case: A 57-year-old male with a history of CML on dasatinib therapy presented to the hospital for nausea and vomiting. A computed tomographic scan revealed a large right-sided pleural effusion with thoracentesis yielding 1.5 liters of chylous fluid. The patient’s hospital course was complicated by intracranial hemorrhage and subsequent admission to the intensive care unit. Dasatinib was stopped during this time. The patient experienced multiple recurrences of this effusion with significant output via thoracentesis and chest tube despite dietary changes. Lymphangiography was performed but revealed no evidence of thoracic duct leakage.\u0000Conclusions: Chylothorax from dasatinib is rare, usually occurs within 1 to 2 years of treatment onset, and resolves with discontinuation. However as supported by this case and others, it may occur as late as 8 years from treatment onset and chylothorax may continually re-accumulate or persist up to 1 year from dasatinib cessation. It is imperative to rule out underlying thoracic duct disruption prior to attributing etiology to dasatinib as a misdiagnosis may result in treatment delays.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"191 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aims to comprehensively assess Entrance Skin Dose (ESD) variability across diverse age groups in various diagnostic areas such as RGU, MCU, Fistulogram, Sinogram, and radiography of SI Joint, Coccyx, and Hip Joint in the pelvic region. The investigation delves into elucidating the range and mean ESD values while identifying factors contributing to fluctuations, enabling precise understanding and strategies for managing radiation exposure in pelvic X-ray examinations. Method & Materials: A qualitative research study took place in one of the hospitals in Dhaka City, Bangladesh, with participation from 138 patients. Radiation protocols in Dhaka City used consistent methods for diverse ages during X-ray examinations. Detailed data on Entrance Skin Dose for various exams like pelvic, SI joint, and fistulogram were meticulously collected and analyzed, aiding in understanding demographic-specific radiation variations. Result: The diverse dataset of Entrance Skin Dose (ESD) measurements across varying age groups in pelvic X-ray examinations reveals a range of ESD values, highlighting fluctuations within specific ages. The overall mean ESD averages approximately 1.87, indicating a moderate consistency in radiation exposure across ages. Notably, certain age brackets, such as patients aged 24 and those in their early teens, exhibit higher ESD values, while others, like ages 15 and 72–76, showcase notable variability. These findings underscore the need for tailored imaging protocols and monitoring strategies in clinical practice. Conclusion: In conclusion, this comprehensive examination underscores the intricate relationship between age, diagnostic areas, and the variability of ESD values, highlighting the need for nuanced approaches in healthcare management to ensure optimized patient outcomes while minimizing radiation exposure risks.
研究目的本研究旨在全面评估不同年龄段人群在骨盆区域RGU、MCU、瘘管造影、窦道造影以及SI关节、尾骨和髋关节放射摄影等不同诊断领域的入口皮肤剂量（ESD）变化情况。调查旨在阐明 ESD 值的范围和平均值，同时确定造成波动的因素，以便准确了解骨盆 X 射线检查中的辐射暴露并制定管理策略：这项定性研究在孟加拉国达卡市的一家医院进行，共有 138 名患者参与。达卡市在 X 光检查中对不同年龄段的患者采用了一致的辐射方案。对骨盆、SI 关节和瘘管造影等各种检查的入口皮肤剂量的详细数据进行了细致的收集和分析，以帮助了解特定人口的辐射差异：结果：骨盆 X 光检查中不同年龄组的皮肤入口剂量（ESD）测量数据集显示了一系列的 ESD 值，突出显示了特定年龄段的波动。ESD的总体平均值约为1.87，表明不同年龄段的辐照量具有适度的一致性。值得注意的是，某些年龄段的患者，如 24 岁和十几岁的患者，ESD 值较高，而其他年龄段的患者，如 15 岁和 72-76 岁的患者，则表现出明显的差异性。这些发现突出表明，在临床实践中需要制定有针对性的成像方案和监测策略：总之，这项全面的检查强调了年龄、诊断领域和 ESD 值的可变性之间错综复杂的关系，突出了在医疗保健管理中采取细致入微的方法的必要性，以确保优化患者的治疗效果，同时最大限度地降低辐射风险。
{"title":"Evaluating Radiation Exposure for Patients During Pelvic X-ray Exams in Dhaka Metropolitan Area, Bangladesh","authors":"Mst. Umme Salma, Md. Abu Obayda, Israt Jahan Nawreen, Tanzila Parvin","doi":"10.24018/ejmed.2024.6.1.2002","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2002","url":null,"abstract":"Objectives: This study aims to comprehensively assess Entrance Skin Dose (ESD) variability across diverse age groups in various diagnostic areas such as RGU, MCU, Fistulogram, Sinogram, and radiography of SI Joint, Coccyx, and Hip Joint in the pelvic region. The investigation delves into elucidating the range and mean ESD values while identifying factors contributing to fluctuations, enabling precise understanding and strategies for managing radiation exposure in pelvic X-ray examinations.\u0000Method & Materials: A qualitative research study took place in one of the hospitals in Dhaka City, Bangladesh, with participation from 138 patients. Radiation protocols in Dhaka City used consistent methods for diverse ages during X-ray examinations. Detailed data on Entrance Skin Dose for various exams like pelvic, SI joint, and fistulogram were meticulously collected and analyzed, aiding in understanding demographic-specific radiation variations.\u0000Result: The diverse dataset of Entrance Skin Dose (ESD) measurements across varying age groups in pelvic X-ray examinations reveals a range of ESD values, highlighting fluctuations within specific ages. The overall mean ESD averages approximately 1.87, indicating a moderate consistency in radiation exposure across ages. Notably, certain age brackets, such as patients aged 24 and those in their early teens, exhibit higher ESD values, while others, like ages 15 and 72–76, showcase notable variability. These findings underscore the need for tailored imaging protocols and monitoring strategies in clinical practice.\u0000Conclusion: In conclusion, this comprehensive examination underscores the intricate relationship between age, diagnostic areas, and the variability of ESD values, highlighting the need for nuanced approaches in healthcare management to ensure optimized patient outcomes while minimizing radiation exposure risks.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"58 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aims to comprehensively assess Entrance Skin Dose (ESD) variability across diverse age groups in various diagnostic areas such as RGU, MCU, Fistulogram, Sinogram, and radiography of SI Joint, Coccyx, and Hip Joint in the pelvic region. The investigation delves into elucidating the range and mean ESD values while identifying factors contributing to fluctuations, enabling precise understanding and strategies for managing radiation exposure in pelvic X-ray examinations. Method & Materials: A qualitative research study took place in one of the hospitals in Dhaka City, Bangladesh, with participation from 138 patients. Radiation protocols in Dhaka City used consistent methods for diverse ages during X-ray examinations. Detailed data on Entrance Skin Dose for various exams like pelvic, SI joint, and fistulogram were meticulously collected and analyzed, aiding in understanding demographic-specific radiation variations. Result: The diverse dataset of Entrance Skin Dose (ESD) measurements across varying age groups in pelvic X-ray examinations reveals a range of ESD values, highlighting fluctuations within specific ages. The overall mean ESD averages approximately 1.87, indicating a moderate consistency in radiation exposure across ages. Notably, certain age brackets, such as patients aged 24 and those in their early teens, exhibit higher ESD values, while others, like ages 15 and 72–76, showcase notable variability. These findings underscore the need for tailored imaging protocols and monitoring strategies in clinical practice. Conclusion: In conclusion, this comprehensive examination underscores the intricate relationship between age, diagnostic areas, and the variability of ESD values, highlighting the need for nuanced approaches in healthcare management to ensure optimized patient outcomes while minimizing radiation exposure risks.
研究目的本研究旨在全面评估不同年龄段人群在骨盆区域RGU、MCU、瘘管造影、窦道造影以及SI关节、尾骨和髋关节放射摄影等不同诊断领域的入口皮肤剂量（ESD）变化情况。调查旨在阐明 ESD 值的范围和平均值，同时确定造成波动的因素，以便准确了解骨盆 X 射线检查中的辐射暴露并制定管理策略：这项定性研究在孟加拉国达卡市的一家医院进行，共有 138 名患者参与。达卡市在 X 光检查中对不同年龄段的患者采用了一致的辐射方案。对骨盆、SI 关节和瘘管造影等各种检查的入口皮肤剂量的详细数据进行了细致的收集和分析，以帮助了解特定人口的辐射差异：结果：骨盆 X 光检查中不同年龄组的皮肤入口剂量（ESD）测量数据集显示了一系列的 ESD 值，突出显示了特定年龄段的波动。ESD的总体平均值约为1.87，表明不同年龄段的辐照量具有适度的一致性。值得注意的是，某些年龄段的患者，如 24 岁和十几岁的患者，ESD 值较高，而其他年龄段的患者，如 15 岁和 72-76 岁的患者，则表现出明显的差异性。这些发现突出表明，在临床实践中需要制定有针对性的成像方案和监测策略：总之，这项全面的检查强调了年龄、诊断领域和 ESD 值的可变性之间错综复杂的关系，突出了在医疗保健管理中采取细致入微的方法的必要性，以确保优化患者的治疗效果，同时最大限度地降低辐射风险。
{"title":"Evaluating Radiation Exposure for Patients During Pelvic X-ray Exams in Dhaka Metropolitan Area, Bangladesh","authors":"Mst. Umme Salma, Md. Abu Obayda, Israt Jahan Nawreen, Tanzila Parvin","doi":"10.24018/ejmed.2024.6.1.2002","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2002","url":null,"abstract":"Objectives: This study aims to comprehensively assess Entrance Skin Dose (ESD) variability across diverse age groups in various diagnostic areas such as RGU, MCU, Fistulogram, Sinogram, and radiography of SI Joint, Coccyx, and Hip Joint in the pelvic region. The investigation delves into elucidating the range and mean ESD values while identifying factors contributing to fluctuations, enabling precise understanding and strategies for managing radiation exposure in pelvic X-ray examinations.\u0000Method & Materials: A qualitative research study took place in one of the hospitals in Dhaka City, Bangladesh, with participation from 138 patients. Radiation protocols in Dhaka City used consistent methods for diverse ages during X-ray examinations. Detailed data on Entrance Skin Dose for various exams like pelvic, SI joint, and fistulogram were meticulously collected and analyzed, aiding in understanding demographic-specific radiation variations.\u0000Result: The diverse dataset of Entrance Skin Dose (ESD) measurements across varying age groups in pelvic X-ray examinations reveals a range of ESD values, highlighting fluctuations within specific ages. The overall mean ESD averages approximately 1.87, indicating a moderate consistency in radiation exposure across ages. Notably, certain age brackets, such as patients aged 24 and those in their early teens, exhibit higher ESD values, while others, like ages 15 and 72–76, showcase notable variability. These findings underscore the need for tailored imaging protocols and monitoring strategies in clinical practice.\u0000Conclusion: In conclusion, this comprehensive examination underscores the intricate relationship between age, diagnostic areas, and the variability of ESD values, highlighting the need for nuanced approaches in healthcare management to ensure optimized patient outcomes while minimizing radiation exposure risks.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"103 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-05DOI: 10.24018/ejmed.2024.6.1.2008
Karar Abdulzahra Mahdi, Dunya Malhan Hanweet, Muhassad H. Al-Mudhafar
Background: Aphthous ulcers (AU) and Rheumatoid Arthritis (RA) are conditions marked by inflammation, with Interleukin 8 (IL-8) playing a significant role in their pathogenesis. This study aims to evaluate the levels of IL-8 in saliva among individuals with AU, RA, both conditions and healthy controls, providing insights into its potential as a diagnostic biomarker and therapeutic target. Methods: The study, endorsed by the Ethics Committee of the University of Kufa, College of Dentistry, Department of Oral Pathology, employed a descriptive, analytical, and cross-sectional approach. Participants included patients with AU, RA, both conditions and a control group, totalling 94 individuals. Exclusion criteria encompassed medication use, other systemic conditions, and lifestyle factors like smoking. Saliva and blood samples were collected for IL-8 concentration measurement using ELISA and for Rheumatoid Factor (RF) and anti-CCP analysis. Results: Analysis showed the highest average salivary IL-8 levels in patients with both AU and RA (483.33 ± 141.20 pg/mL), followed by the RA group (338.57 ± 79.11 pg/mL), the AU group (381 ± 108.48 pg/mL), and the control group (213.69 ± 84.65 pg/mL). Significant differences in IL-8 levels were observed between these groups, with the combined AU and RA groups showing the highest concentrations. However, the variation in IL-8 levels between those who have both AU and RA and those with only RA was not statistically significant. Conclusion: The study highlights a distinct elevation in salivary IL-8 levels in patients with AU and RA, particularly in those suffering from both conditions.
背景：阿弗他溃疡（AU）和类风湿性关节炎（RA）是以炎症为特征的疾病，白细胞介素8（IL-8）在其发病机制中起着重要作用。本研究旨在评估AU、RA两种疾病患者和健康对照组唾液中IL-8的水平，从而深入了解其作为诊断生物标志物和治疗靶点的潜力：本研究经库法大学牙科学院口腔病理学系伦理委员会批准，采用了描述性、分析性和横断面方法。参与者包括AU、RA、两种情况的患者和对照组，共计94人。排除标准包括药物使用、其他系统疾病以及吸烟等生活方式因素。采集唾液和血液样本，用酶联免疫吸附法测定IL-8浓度，并分析类风湿因子（RF）和抗CCP：分析显示，AU 和 RA 患者的唾液 IL-8 平均水平最高（483.33 ± 141.20 pg/mL），其次是 RA 组（338.57 ± 79.11 pg/mL）、AU 组（381 ± 108.48 pg/mL）和对照组（213.69 ± 84.65 pg/mL）。这些组之间的 IL-8 水平存在显著差异，其中 AU 和 RA 组的浓度最高。然而，同时患有 AU 和 RA 的人群与仅患有 RA 的人群之间 IL-8 水平的差异无统计学意义：结论：本研究强调了AU和RA患者唾液中IL-8水平的明显升高，尤其是同时患有这两种疾病的患者。
{"title":"Elevated Salivary IL-8 Levels in Patients with Aphthous Ulceration and Rheumatoid Arthritis: A Cross-Sectional Study","authors":"Karar Abdulzahra Mahdi, Dunya Malhan Hanweet, Muhassad H. Al-Mudhafar","doi":"10.24018/ejmed.2024.6.1.2008","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2008","url":null,"abstract":"Background: Aphthous ulcers (AU) and Rheumatoid Arthritis (RA) are conditions marked by inflammation, with Interleukin 8 (IL-8) playing a significant role in their pathogenesis. This study aims to evaluate the levels of IL-8 in saliva among individuals with AU, RA, both conditions and healthy controls, providing insights into its potential as a diagnostic biomarker and therapeutic target.\u0000Methods: The study, endorsed by the Ethics Committee of the University of Kufa, College of Dentistry, Department of Oral Pathology, employed a descriptive, analytical, and cross-sectional approach. Participants included patients with AU, RA, both conditions and a control group, totalling 94 individuals. Exclusion criteria encompassed medication use, other systemic conditions, and lifestyle factors like smoking. Saliva and blood samples were collected for IL-8 concentration measurement using ELISA and for Rheumatoid Factor (RF) and anti-CCP analysis.\u0000Results: Analysis showed the highest average salivary IL-8 levels in patients with both AU and RA (483.33 ± 141.20 pg/mL), followed by the RA group (338.57 ± 79.11 pg/mL), the AU group (381 ± 108.48 pg/mL), and the control group (213.69 ± 84.65 pg/mL). Significant differences in IL-8 levels were observed between these groups, with the combined AU and RA groups showing the highest concentrations. However, the variation in IL-8 levels between those who have both AU and RA and those with only RA was not statistically significant.\u0000Conclusion: The study highlights a distinct elevation in salivary IL-8 levels in patients with AU and RA, particularly in those suffering from both conditions.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"30 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139865330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-05DOI: 10.24018/ejmed.2024.6.1.2008
Karar Abdulzahra Mahdi, Dunya Malhan Hanweet, Muhassad H. Al-Mudhafar
Background: Aphthous ulcers (AU) and Rheumatoid Arthritis (RA) are conditions marked by inflammation, with Interleukin 8 (IL-8) playing a significant role in their pathogenesis. This study aims to evaluate the levels of IL-8 in saliva among individuals with AU, RA, both conditions and healthy controls, providing insights into its potential as a diagnostic biomarker and therapeutic target. Methods: The study, endorsed by the Ethics Committee of the University of Kufa, College of Dentistry, Department of Oral Pathology, employed a descriptive, analytical, and cross-sectional approach. Participants included patients with AU, RA, both conditions and a control group, totalling 94 individuals. Exclusion criteria encompassed medication use, other systemic conditions, and lifestyle factors like smoking. Saliva and blood samples were collected for IL-8 concentration measurement using ELISA and for Rheumatoid Factor (RF) and anti-CCP analysis. Results: Analysis showed the highest average salivary IL-8 levels in patients with both AU and RA (483.33 ± 141.20 pg/mL), followed by the RA group (338.57 ± 79.11 pg/mL), the AU group (381 ± 108.48 pg/mL), and the control group (213.69 ± 84.65 pg/mL). Significant differences in IL-8 levels were observed between these groups, with the combined AU and RA groups showing the highest concentrations. However, the variation in IL-8 levels between those who have both AU and RA and those with only RA was not statistically significant. Conclusion: The study highlights a distinct elevation in salivary IL-8 levels in patients with AU and RA, particularly in those suffering from both conditions.
背景：阿弗他溃疡（AU）和类风湿性关节炎（RA）是以炎症为特征的疾病，白细胞介素8（IL-8）在其发病机制中起着重要作用。本研究旨在评估AU、RA两种疾病患者和健康对照组唾液中IL-8的水平，从而深入了解其作为诊断生物标志物和治疗靶点的潜力：本研究经库法大学牙科学院口腔病理学系伦理委员会批准，采用了描述性、分析性和横断面方法。参与者包括AU、RA、两种情况的患者和对照组，共计94人。排除标准包括药物使用、其他系统疾病以及吸烟等生活方式因素。采集唾液和血液样本，用酶联免疫吸附法测定IL-8浓度，并分析类风湿因子（RF）和抗CCP：分析显示，AU 和 RA 患者的唾液 IL-8 平均水平最高（483.33 ± 141.20 pg/mL），其次是 RA 组（338.57 ± 79.11 pg/mL）、AU 组（381 ± 108.48 pg/mL）和对照组（213.69 ± 84.65 pg/mL）。这些组之间的 IL-8 水平存在显著差异，其中 AU 和 RA 组的浓度最高。然而，同时患有 AU 和 RA 的人群与仅患有 RA 的人群之间 IL-8 水平的差异无统计学意义：结论：本研究强调了AU和RA患者唾液中IL-8水平的明显升高，尤其是同时患有这两种疾病的患者。
{"title":"Elevated Salivary IL-8 Levels in Patients with Aphthous Ulceration and Rheumatoid Arthritis: A Cross-Sectional Study","authors":"Karar Abdulzahra Mahdi, Dunya Malhan Hanweet, Muhassad H. Al-Mudhafar","doi":"10.24018/ejmed.2024.6.1.2008","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.2008","url":null,"abstract":"Background: Aphthous ulcers (AU) and Rheumatoid Arthritis (RA) are conditions marked by inflammation, with Interleukin 8 (IL-8) playing a significant role in their pathogenesis. This study aims to evaluate the levels of IL-8 in saliva among individuals with AU, RA, both conditions and healthy controls, providing insights into its potential as a diagnostic biomarker and therapeutic target.\u0000Methods: The study, endorsed by the Ethics Committee of the University of Kufa, College of Dentistry, Department of Oral Pathology, employed a descriptive, analytical, and cross-sectional approach. Participants included patients with AU, RA, both conditions and a control group, totalling 94 individuals. Exclusion criteria encompassed medication use, other systemic conditions, and lifestyle factors like smoking. Saliva and blood samples were collected for IL-8 concentration measurement using ELISA and for Rheumatoid Factor (RF) and anti-CCP analysis.\u0000Results: Analysis showed the highest average salivary IL-8 levels in patients with both AU and RA (483.33 ± 141.20 pg/mL), followed by the RA group (338.57 ± 79.11 pg/mL), the AU group (381 ± 108.48 pg/mL), and the control group (213.69 ± 84.65 pg/mL). Significant differences in IL-8 levels were observed between these groups, with the combined AU and RA groups showing the highest concentrations. However, the variation in IL-8 levels between those who have both AU and RA and those with only RA was not statistically significant.\u0000Conclusion: The study highlights a distinct elevation in salivary IL-8 levels in patients with AU and RA, particularly in those suffering from both conditions.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139805432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.24018/ejmed.2024.6.1.1994
Edwin Chandraharan, Mareike Bolten
Chorioamnionitis refers to the inflammation of the chorion and amnion by the bacteria and their toxins as well as by the inflammatory cytokines. Therefore, it is a fetal disease with the bacteria, their toxins as well as the fetal immunological responses involving inflammatory cytokines (interleukins, interferons, and tumour necrosis factor-alpha) exerting their detrimental effects within the fetal compartment (i.e., amniotic fluid, fetal membranes, the placenta, and fetal tissues and organs). The vast majority of fetal inflammation occurs as a result of an ascending infection (i.e., entry of the bacteria from the maternal genital tract through the cervix). Therefore, maternal signs (tachycardia and pyrexia) may not be observed until the late stages of the disease. Cardiotocograph (CTG) trace was introduced into clinical practice in the 1960s as a tool to timely recognise ongoing fetal hypoxic stress so that immediate action could be taken to avoid hypoxic ischaemic encephalopathy (HIE) and/ or intrapartum hypoxia-related perinatal deaths. Unfortunately, the CTG was introduced into clinical practice without any prior randomised controlled trials, which resulted in panicking and reacting to the observed morphology of fetal heart rate decelerations, which reflect an ongoing fetal compensatory response to reduce the myocardial workload. A sudden and reflex reduction of the heart rate in response to ongoing intermittent hypoxic stress (i.e., repetitive compression of the umbilical cord or interruptions in uteroplacental oxygenation due to uterine contractions) would ensure a reduction in myocardial oxygen demand and maintenance of aerobic metabolism to avoid the onset of anaerobic metabolism and production of lactic acid within the myocardium. Lack of understanding of fetal compensatory responses resulted in the illogical approach of grouping arbitrary features into different categories and then randomly combining them to classify the CTG traces into “Normal, Suspicious, and Pathological”. The same parameters were used in fetuses with chorioamnionitis with an alternative, inflammatory pathway of neurological injury. The international consensus guidelines of physiological interpretation of CTG produced by 44 CTG experts from 14 countries in 2018 ensured a paradigm shift and recommended classification of CTG traces based on the type of fetal hypoxia and fetal response to stress, by applying the knowledge of fetal physiology whilst interpreting CTG traces. During the last 5 years, research has highlighted CTG features in fetal neuro-inflammation, which include an absence of fetal heart rate cycling, the ZigZag Pattern, and sinusoidal patterns. The proposed “Chorio Duck Score” is a scoring system based on recently published scientific evidence on CTG features in subclinical and clinical chorioamnionitis to enable timely diagnosis of fetal systemic inflammatory response syndrome (FIRS). This will help avoid the continuation of super-imposed hypoxic stress
{"title":"Recognition of Chorioamnionitis on the Cardiotocograph (CTG): The role of the “Chorio Duck Score”","authors":"Edwin Chandraharan, Mareike Bolten","doi":"10.24018/ejmed.2024.6.1.1994","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.1994","url":null,"abstract":"Chorioamnionitis refers to the inflammation of the chorion and amnion by the bacteria and their toxins as well as by the inflammatory cytokines. Therefore, it is a fetal disease with the bacteria, their toxins as well as the fetal immunological responses involving inflammatory cytokines (interleukins, interferons, and tumour necrosis factor-alpha) exerting their detrimental effects within the fetal compartment (i.e., amniotic fluid, fetal membranes, the placenta, and fetal tissues and organs). The vast majority of fetal inflammation occurs as a result of an ascending infection (i.e., entry of the bacteria from the maternal genital tract through the cervix). Therefore, maternal signs (tachycardia and pyrexia) may not be observed until the late stages of the disease. Cardiotocograph (CTG) trace was introduced into clinical practice in the 1960s as a tool to timely recognise ongoing fetal hypoxic stress so that immediate action could be taken to avoid hypoxic ischaemic encephalopathy (HIE) and/ or intrapartum hypoxia-related perinatal deaths. Unfortunately, the CTG was introduced into clinical practice without any prior randomised controlled trials, which resulted in panicking and reacting to the observed morphology of fetal heart rate decelerations, which reflect an ongoing fetal compensatory response to reduce the myocardial workload. A sudden and reflex reduction of the heart rate in response to ongoing intermittent hypoxic stress (i.e., repetitive compression of the umbilical cord or interruptions in uteroplacental oxygenation due to uterine contractions) would ensure a reduction in myocardial oxygen demand and maintenance of aerobic metabolism to avoid the onset of anaerobic metabolism and production of lactic acid within the myocardium. Lack of understanding of fetal compensatory responses resulted in the illogical approach of grouping arbitrary features into different categories and then randomly combining them to classify the CTG traces into “Normal, Suspicious, and Pathological”. The same parameters were used in fetuses with chorioamnionitis with an alternative, inflammatory pathway of neurological injury. The international consensus guidelines of physiological interpretation of CTG produced by 44 CTG experts from 14 countries in 2018 ensured a paradigm shift and recommended classification of CTG traces based on the type of fetal hypoxia and fetal response to stress, by applying the knowledge of fetal physiology whilst interpreting CTG traces. During the last 5 years, research has highlighted CTG features in fetal neuro-inflammation, which include an absence of fetal heart rate cycling, the ZigZag Pattern, and sinusoidal patterns. The proposed “Chorio Duck Score” is a scoring system based on recently published scientific evidence on CTG features in subclinical and clinical chorioamnionitis to enable timely diagnosis of fetal systemic inflammatory response syndrome (FIRS). This will help avoid the continuation of super-imposed hypoxic stress","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"29 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-03DOI: 10.24018/ejmed.2024.6.1.1936
E. Nuglozeh, M. F. Fazaludeen, Sumukh Deshpande, Aymen A. Warille, Mustafa Kürşat Şahin
Chronic kidney disease is a combination of many vascular diseases involving mutations of many genes. Hypertension diabetes and atherosclerosis are the most common causes of kidney disease, with hypertension causing just over a quarter of all cases of kidney failure and diabetes causing one-third of them. Other much less common conditions that can cause CKD include inflammation, infections, genetic factors, or longstanding blockage to the urinary system (such as enlarged prostate or kidney stones). In many cases, the causes remained unknown, albeit the manifestation of the diseases with clear phenotypes and biochemical profiles. Heredity and genetic determinants play major roles in the initiation, development, and establishment of CKD. Kidney disease phenotypes can be dissected into many underlying causing candidates’ genes and many molecular genetics approaches are striving to lift the veil on this nagging disease. Recent studies using genetic testing have demonstrated that Mendelian etiologies account for approximately 20% of cases of kidney disease of unknown etiology. CKD is known to be plagued with many genes mutations like mutation in Autosomal Dominant Polycystic Kidney Disease (ADPKD) and mutations in MYH9 and APOL1 genes, COL4A3, COL4A4, and COL4A5 genes playing important roles in the CKD picture. Genetic testing has modernized and revolutionized many areas of medical practices and diagnosis of many diseases and the field of nephrology is not an exception. The advance in Next-generation Sequencing, including whole exome sequencing has proven to be a powerful tool in personalized medicine and for potential noninvasive decryption for biomarkers in kidney disease thereby paving the way for better diagnostic purposes. In this regard, we run whole exome sequencing on whole blood genomic DNA from CKD patients. Bioinformatics analysis led us to uncover a total of more than 3000 single nucleotide polymorphisms (SNPs). To sort out these flurries of targeted SNPs, we undertook filtration using an R-algorithm in combination with the diseases association Clinvar database. This approach led us to 12 combined diagnostic missense variants scattered on different chromosomes. Combined missense reduction after FDR filtration with a Cellrate of 0.75 generated two missense variants located on PCSK9 and GHR genes on chromosomes 1 and 5 and lastly, reduction variants after Filtration by spliced region bring us to a single SNP located on the PCSK9 gene.
{"title":"Growth Hormone Receptor and PCSK9 Define a New Paradigm in the Initiation and Development of Chronic Kidney Disease as Revealed by Exome Sequencing on Illumina Platform","authors":"E. Nuglozeh, M. F. Fazaludeen, Sumukh Deshpande, Aymen A. Warille, Mustafa Kürşat Şahin","doi":"10.24018/ejmed.2024.6.1.1936","DOIUrl":"https://doi.org/10.24018/ejmed.2024.6.1.1936","url":null,"abstract":"Chronic kidney disease is a combination of many vascular diseases involving mutations of many genes. Hypertension diabetes and atherosclerosis are the most common causes of kidney disease, with hypertension causing just over a quarter of all cases of kidney failure and diabetes causing one-third of them. Other much less common conditions that can cause CKD include inflammation, infections, genetic factors, or longstanding blockage to the urinary system (such as enlarged prostate or kidney stones). In many cases, the causes remained unknown, albeit the manifestation of the diseases with clear phenotypes and biochemical profiles. Heredity and genetic determinants play major roles in the initiation, development, and establishment of CKD. Kidney disease phenotypes can be dissected into many underlying causing candidates’ genes and many molecular genetics approaches are striving to lift the veil on this nagging disease. Recent studies using genetic testing have demonstrated that Mendelian etiologies account for approximately 20% of cases of kidney disease of unknown etiology. CKD is known to be plagued with many genes mutations like mutation in Autosomal Dominant Polycystic Kidney Disease (ADPKD) and mutations in MYH9 and APOL1 genes, COL4A3, COL4A4, and COL4A5 genes playing important roles in the CKD picture. Genetic testing has modernized and revolutionized many areas of medical practices and diagnosis of many diseases and the field of nephrology is not an exception. The advance in Next-generation Sequencing, including whole exome sequencing has proven to be a powerful tool in personalized medicine and for potential noninvasive decryption for biomarkers in kidney disease thereby paving the way for better diagnostic purposes. In this regard, we run whole exome sequencing on whole blood genomic DNA from CKD patients. Bioinformatics analysis led us to uncover a total of more than 3000 single nucleotide polymorphisms (SNPs). To sort out these flurries of targeted SNPs, we undertook filtration using an R-algorithm in combination with the diseases association Clinvar database. This approach led us to 12 combined diagnostic missense variants scattered on different chromosomes. Combined missense reduction after FDR filtration with a Cellrate of 0.75 generated two missense variants located on PCSK9 and GHR genes on chromosomes 1 and 5 and lastly, reduction variants after Filtration by spliced region bring us to a single SNP located on the PCSK9 gene.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":"50 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-29DOI: 10.24018/ejmed.2023.5.6.1989
O. Bolgova, I. Shypilova, Larysa Sankova, Volodymyr Mavrych
The burgeoning interest in leveraging ChatGPT within the medical field underscores the necessity for a comprehensive understanding of its capabilities and limitations, particularly in the context of medical assessments and examinations. The model possesses a unique aptitude for addressing queries related to medical student exams, thereby serving as an invaluable resource for academic support. Its advanced natural language processing capabilities empower it to comprehend the intricacies of medical terminology, enabling it to provide nuanced and contextually relevant responses. This study aimed to quantitatively evaluate ChatGPT performance in answering Multiple Choice Questions (MCQs) related to the different topics in Gross Anatomy course for medical students. The research conducted for this study was focused on a comprehensive examination of ChatGPT (GPT-3.5) capabilities in answering 325 MCQs designed in USMLE style, arranged in 7 different sets related to specific topics. These questions were selected from Gross Anatomy course exam database for medical students and reviewed by three independent experts. The results of 5 successive attempts to answer each set of questions by Chat-GPT were evaluated based on accuracy, relevance, and comprehensiveness. The ChatGPT provided accurate answers to 44.1% ± 8.2% of questions. Accordingly, to our data, ChatGPT is answering much better on MCQs from Back material (58.4%), following Head and Neck (48.8%) and Pelvis (45.6%), and performing not so well in questions of Thorax (37.6%) and Upper limb (36.4%). ChatGPT is struggling in answering questions about blood supply and innervation of the specific organs. ChatGPT stands out as a promising and interactive educational tool, particularly for students engaged in the study of anatomy. Its distinctive ability to not only provide informative responses but also engage students in a conversational manner is highly commendable. This quality has the potential to enhance student engagement and foster curiosity, creating a dynamic learning experience. However, it’s crucial to acknowledge that ChatGPT’s current level of comprehension and interpretative abilities may not meet the demanding standards required for practical applications in the medical education domain. Its performance in challenging examinations like medical college exams and health licensing exams might need to catch up to expectations.
{"title":"How Well Did ChatGPT Perform in Answering Questions on Different Topics in Gross Anatomy?","authors":"O. Bolgova, I. Shypilova, Larysa Sankova, Volodymyr Mavrych","doi":"10.24018/ejmed.2023.5.6.1989","DOIUrl":"https://doi.org/10.24018/ejmed.2023.5.6.1989","url":null,"abstract":"The burgeoning interest in leveraging ChatGPT within the medical field underscores the necessity for a comprehensive understanding of its capabilities and limitations, particularly in the context of medical assessments and examinations. The model possesses a unique aptitude for addressing queries related to medical student exams, thereby serving as an invaluable resource for academic support. Its advanced natural language processing capabilities empower it to comprehend the intricacies of medical terminology, enabling it to provide nuanced and contextually relevant responses. This study aimed to quantitatively evaluate ChatGPT performance in answering Multiple Choice Questions (MCQs) related to the different topics in Gross Anatomy course for medical students. The research conducted for this study was focused on a comprehensive examination of ChatGPT (GPT-3.5) capabilities in answering 325 MCQs designed in USMLE style, arranged in 7 different sets related to specific topics. These questions were selected from Gross Anatomy course exam database for medical students and reviewed by three independent experts. The results of 5 successive attempts to answer each set of questions by Chat-GPT were evaluated based on accuracy, relevance, and comprehensiveness. The ChatGPT provided accurate answers to 44.1% ± 8.2% of questions. Accordingly, to our data, ChatGPT is answering much better on MCQs from Back material (58.4%), following Head and Neck (48.8%) and Pelvis (45.6%), and performing not so well in questions of Thorax (37.6%) and Upper limb (36.4%). ChatGPT is struggling in answering questions about blood supply and innervation of the specific organs. ChatGPT stands out as a promising and interactive educational tool, particularly for students engaged in the study of anatomy. Its distinctive ability to not only provide informative responses but also engage students in a conversational manner is highly commendable. This quality has the potential to enhance student engagement and foster curiosity, creating a dynamic learning experience. However, it’s crucial to acknowledge that ChatGPT’s current level of comprehension and interpretative abilities may not meet the demanding standards required for practical applications in the medical education domain. Its performance in challenging examinations like medical college exams and health licensing exams might need to catch up to expectations.","PeriodicalId":508733,"journal":{"name":"European Journal of Medical and Health Sciences","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139145316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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