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Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations. 通过症状群研究推进症状科学:专家组会议记录和建议。
IF 9.9 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2017-01-24 Print Date: 2017-04-01 DOI: 10.1093/jnci/djw253
Christine Miaskowski, Andrea Barsevick, Ann Berger, Rocco Casagrande, Patricia A Grady, Paul Jacobsen, Jean Kutner, Donald Patrick, Lani Zimmerman, Canhua Xiao, Martha Matocha, Sue Marden

An overview of proceedings, findings, and recommendations from the workshop on "Advancing Symptom Science Through Symptom Cluster Research" sponsored by the National Institute of Nursing Research (NINR) and the Office of Rare Diseases Research, National Center for Advancing Translational Sciences, is presented. This workshop engaged an expert panel in an evidenced-based discussion regarding the state of the science of symptom clusters in chronic conditions including cancer and other rare diseases. An interdisciplinary working group from the extramural research community representing nursing, medicine, oncology, psychology, and bioinformatics was convened at the National Institutes of Health. Based on expertise, members were divided into teams to address key areas: defining characteristics of symptom clusters, priority symptom clusters and underlying mechanisms, measurement issues, targeted interventions, and new analytic strategies. For each area, the evidence was synthesized, limitations and gaps identified, and recommendations for future research delineated. The majority of findings in each area were from studies of oncology patients. However, increasing evidence suggests that symptom clusters occur in patients with other chronic conditions (eg, pulmonary, cardiac, and end-stage renal disease). Nonetheless, symptom cluster research is extremely limited and scientists are just beginning to understand how to investigate symptom clusters by developing frameworks and new methods and approaches. With a focus on personalized care, an understanding of individual susceptibility to symptoms and whether a "driving" symptom exists that triggers other symptoms in the cluster is needed. Also, research aimed at identifying the mechanisms that underlie symptom clusters is essential to developing targeted interventions.

本文概述了由美国国家护理研究所 (NINR) 和国家促进转化科学中心罕见病研究办公室 (Office of Rare Diseases Research, National Center for Advancing Translational Sciences) 主办的 "通过症状群研究促进症状科学 "研讨会的会议记录、发现和建议。该研讨会邀请专家小组就慢性病(包括癌症和其他罕见病)症状群的科学现状进行了循证讨论。美国国立卫生研究院召集了一个来自校外研究界的跨学科工作小组,代表护理、医学、肿瘤学、心理学和生物信息学。根据专业知识,工作组成员被分成若干小组,分别负责以下关键领域:症状群特征的定义、优先症状群和潜在机制、测量问题、有针对性的干预措施以及新的分析策略。对每个领域的证据进行了综合,找出了局限性和差距,并为今后的研究提出了建议。每个领域的大部分研究结果都来自对肿瘤患者的研究。然而,越来越多的证据表明,其他慢性疾病(如肺病、心脏病和终末期肾病)患者也会出现症状群。然而,症状群的研究极为有限,科学家们也刚刚开始了解如何通过开发框架和新方法来研究症状群。为了实现个性化护理,需要了解个人对症状的易感性,以及是否存在一个 "驱动 "症状来触发症状群中的其他症状。此外,旨在确定症状集群基础机制的研究对于制定有针对性的干预措施至关重要。
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引用次数: 0
Improved Data Preprocessing Algorithm for Time-Domain Induced Polarization Method with Digital Notch Filter 改进的数字陷波滤波器时域诱导偏振法数据预处理算法
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0015
Shuang-Chao Ge, M. Deng, Kai Chen, Bin Li, Yuan Li
Time-domain induced polarization (TDIP) measurement is seriously affected by power line interference and other field noise. Moreover, existing TDIP instruments generally output only the apparent chargeability, without providing complete secondary field information. To increase the robustness of TDIP method against interference and obtain more detailed secondary field information, an improved data-processing algorithm is proposed here. This method includes an efficient digital notch filter which can effectively eliminate all the main components of the power line interference. Hardware model of this filter was constructed and Vhsic Hardware Description Language code for it was generated using Digital Signal Processor Builder. In addition, a time-location method was proposed to extract secondary field information in case of unexpected data loss or failure of the synchronous technologies. Finally, the validity and accuracy of the method and the notch filter were verified by using the Cole-Cole model implemented by Simulink software. Moreover, indoor and field tests confirmed the application effect of the algorithm in the fieldwork.
时域感应极化(TDIP)测量受到电力线干扰和其他场噪声的严重影响。此外,现有的TDIP仪器通常只输出表面电荷率,而不提供完整的次级油田信息。为了提高TDIP方法对干扰的鲁棒性,获得更详细的二次场信息,本文提出了一种改进的数据处理算法。该方法包括一个高效的数字陷波滤波器,可以有效地消除电力线各主要分量的干扰。构建了该滤波器的硬件模型,并利用数字信号处理器生成器生成了该滤波器的Vhsic硬件描述语言代码。此外,提出了一种时间定位方法,在同步技术发生意外数据丢失或失效时提取二次现场信息。最后,利用Simulink软件实现的Cole-Cole模型验证了该方法和陷波滤波器的有效性和准确性。通过室内和现场试验,验证了该算法在现场的应用效果。
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引用次数: 5
Oil Formation Volume Factor Determination Through a Fused Intelligence 基于融合智能的储层体积因子确定
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0099
A. Gholami
Volume change of oil between reservoir condition and standard surface condition is called oil formation volume factor (FVF), which is very time, cost and labor intensive to determine. This study proposes an accurate, rapid and cost-effective approach for determining FVF from reservoir temperature, dissolved gas oil ratio, and specific gravity of both oil and dissolved gas. Firstly, structural risk minimization (SRM) principle of support vector regression (SVR) was employed to construct a robust model for estimating FVF from the aforementioned inputs. Subsequently, an alternating conditional expectation (ACE) was used for approximating optimal transformations of input/output data to a higher correlated data and consequently developing a sophisticated model between transformed data. Eventually, a committee machine with SVR and ACE was constructed through the use of hybrid genetic algorithm-pattern search (GA-PS). Committee machine integrates ACE and SVR models in an optimal linear combination such that makes benefit of both methods. A group of 342 data points was used for model development and a group of 219 data points was used for blind testing the constructed model. Results indicated that the committee machine performed better than individual models.
油层条件与标准地面条件之间的油体积变化量称为油层体积因子(FVF),它的确定非常耗时、费钱、费力。该研究提出了一种准确、快速、经济的方法,可以根据储层温度、溶解气油比以及油和溶解气的比重来确定FVF。首先,利用支持向量回归(SVR)的结构风险最小化(SRM)原理,构建了基于上述输入估计FVF的鲁棒模型;随后,交替条件期望(ACE)用于逼近输入/输出数据到更高相关数据的最佳转换,从而在转换后的数据之间建立复杂的模型。最后,利用遗传算法-模式搜索(GA-PS)构建了一个具有SVR和ACE的委员会机。委员会机将ACE模型和SVR模型以最优线性组合的方式集成在一起,使两种方法都受益。一组342个数据点用于模型开发,一组219个数据点用于盲测构建的模型。结果表明,委员会机器的性能优于单个模型。
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引用次数: 2
Variations of Strength, Resistivity and Thermal Parameters of Clay after High Temperature Treatment 高温处理后粘土强度、电阻率及热参数的变化
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0090
Qiang Sun, Weiqiang Zhang, Yuliang Zhang, Lining Yang
This paper reports the variations of strength, resistivity and thermal parameters of clay after high-temperature heating. Experiments were carried out to test the physical properties of clay heated at temperatures ranging from room temperature to 800°C in a furnace. The experiment results show that below 400°C the uniaxial compressive strength and resistivity change very little. However, above 400°C, both increase rapidly. At a temperature under 400°C, the thermal conductivity and specific heat capacity decrease significantly. The thermogravimetric analysis (TG) and differential scanning calorimeter (DSC) test indicate that a series of changes occur in kaolinite at temperatures from 400 to 600°C, which is considered the primary cause of the variation of physical and mechanical properties of clay under high temperatures.
本文报道了高温加热后粘土的强度、电阻率和热参数的变化。实验测试了粘土在室温至800℃的炉内加热后的物理性能。实验结果表明,在400℃以下,单轴抗压强度和电阻率变化很小。然而,在400°C以上,两者都迅速增加。当温度低于400℃时,导热系数和比热容显著降低。热重分析(TG)和差示扫描量热仪(DSC)测试表明,在400 ~ 600℃高温下,高岭石发生了一系列变化,这被认为是高温下粘土物理力学性能变化的主要原因。
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引用次数: 9
Shear Wave Velocity Estimates through Combined Use of Passive Techniques in a Tectonically Active Area 在构造活动区联合使用被动技术估算横波速度
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0086
R. Biswas, S. Baruah
We made an attempt to assess the shear wave velocity values VS and, to a lesser extent, the VP values from ambient noise recordings in an array configuration. Five array sites were situated in the close proximity to borehole sites. Shear wave velocity profiles were modeled at these five array sites with the aid of two computational techniques, viz. spatial autocorrelation (SPAC) and H/V ellipticity. Out of these five array sites, velocity estimates could be reliably inferred at three locations. The shear wave velocities estimated by these methods are found to be quite consistent with each other. The computed VS values up to 30 m depth are in the range from 275 to 375 m/s in most of the sites, which implies prevalence of a low velocity zone at some pocket areas. The results were corroborated by evidence of site geology as well as geotechnical information.
我们尝试评估横波速度值VS,在较小程度上,从阵列配置的环境噪声记录中评估VP值。五个阵列点位于靠近钻孔点的位置。利用空间自相关(SPAC)和H/V椭圆度两种计算技术,对这5个阵列点的横波速度分布进行了建模。在这五个阵列站点中,可以可靠地推断出三个位置的速度估计。用这些方法计算出的横波速度是相当一致的。在大多数地点,30 m深度的计算VS值在275 ~ 375 m/s之间,这意味着在一些口袋区域存在低速带。这些结果得到了现场地质证据和岩土工程信息的证实。
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引用次数: 9
The Relationship of Stratospheric QBO with the Difference of Measured and Calculated NmF2 平流层QBO与实测与计算NmF2差的关系
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0061
K. Kurt, A. Yesil, S. Sağır, R. Atıcı
The relationship between stratospheric QBO and the difference (ΔNmF2) between NmF2 calculated with IRI-2012 and measured from ionosondes at the Singapore and Ascension stations in the equatorial region was statistically investigated. As statistical analysis, the regression analysis was used on variables. As a result, the relationship between QBO and ΔNmF2 was higher for 24:00 LT (local time) than 12:00 LT. This relationship is positive in the solar maximum epoch for both stations. In the solar minimum epoch, it is negative at 24:00 LT for Ascension and at 12:00 LT for Singapore. Furthermore, it was seen that the relationship of the ΔNmF2 with both the easterly and westerly QBO was negative for all solar epochs and every LT, at Ascension station. This relationship was only positive for solar maximum epoch and 12:00 LT, at Singapore station.
利用IRI-2012计算的NmF2与赤道地区新加坡站和阿森松站电离空仪测量的NmF2的差值(ΔNmF2)与平流层QBO的关系进行了统计研究。作为统计分析,对变量进行回归分析。结果表明,在24时(当地时间),QBO与ΔNmF2的关系大于12时(当地时间),这种关系在两个台站的太阳极大期都是正相关的。在太阳极小期,它是负的,在24点LT的扬升和12点LT的新加坡。此外,在阿森松站,ΔNmF2与东、西风QBO在所有太阳期和每个LT都呈负相关。这种关系仅在新加坡站的太阳极大期和12点LT时为正。
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引用次数: 17
Experimental and Numerical Analysis of Air Trapping in a Porous Medium with Coarse Textured Inclusions 含粗织构夹杂的多孔介质中空气捕集的实验与数值分析
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0095
Paulina Szymańska, Witold Tisler, C. Schütz, A. Szymkiewicz, I. Neuweiler, R. Helmig
The paper presents a 2D upward infiltration experiment performed on a model porous medium consisting of fine sand background with two inclusions made of coarser sands. The purpose of the experiment was to investigate the effects of structural air trapping, which occurs during infiltration as a result of heterogeneous material structure. The experiment shows that a significant amount of air becomes trapped in each of the inclusions. Numerical simulations were carried out using the two-phase water-air flow model and the Richards equation. The experimental results can be reproduced with good accuracy only using a two-phase flow model, which accounts for both structural and pore-scale trapping. On the other hand, the Richards equation was not able to represent the structural trapping caused by material heterogeneity.
本文在细砂为背景、粗砂为包裹体的模型多孔介质上进行了二维向上入渗实验。本实验的目的是研究在渗透过程中由于材料结构不均匀而发生的结构空气捕获的影响。实验表明,大量的空气被困在每个包裹体中。采用水-气两相流动模型和Richards方程进行了数值模拟。仅使用两相流模型即可较好地再现实验结果,该模型同时考虑了结构和孔隙尺度的捕获。另一方面,理查兹方程不能表征由材料非均质性引起的结构俘获。
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引用次数: 5
Acoustic Full Waveforms as a Bridge between Seismic Data and Laboratory Results in Petrophysical Interpretation 声波全波形作为岩石物理解释中地震数据与实验室结果之间的桥梁
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0116
K. Wawrzyniak-Guz
Mutual relationships between geological and geophysical data obtained by using methods of different scale are presented for the Miocene sandy-shaly thin-bedded formation and for the Zechstein carbonate formation. The common basis of laboratory results, well logging and seismic data was a recognition of elastic and reservoir properties of rocks. The common basis of laboratory results, well logging and seismic data were elastic and reservoir properties of rocks. Seismic attributes calculated from acoustic full waveforms were a link between the considered data. Seismic attributes strongly depend on small changes observed in rock formation related to lithology variations, facies changes, structural events and petrophysical properties variability. The observed trends and relationships of high correlation coefficients in the analysed data proved the assumption made at the beginning of research that common physical basis is a platform for data scaling. Proper scaling enables expanding the relationships determined from laboratory and well logging of petrophysical parameters to a seismic scale.
介绍了中新世砂质-泥质薄层地层和Zechstein碳酸盐岩地层不同尺度的地质资料与地球物理资料之间的相互关系。实验室结果、测井和地震资料的共同基础是对岩石的弹性和储层性质的认识。实验室结果、测井和地震资料的共同基础是岩石的弹性和储层性质。从声学全波形计算的地震属性是考虑数据之间的联系。地震属性在很大程度上取决于观察到的与岩性变化、相变化、构造事件和岩石物理性质变化有关的岩层中的微小变化。在分析数据中观察到的高相关系数的趋势和关系证明了研究开始时的假设,即共同的物理基础是数据缩放的平台。适当的尺度调整可以将实验室和测井确定的岩石物理参数的关系扩展到地震尺度。
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引用次数: 4
Very Low Frequency Electromagnetic Induction Surveys in Hydrogeological Investigations; Case Study from Poland 甚低频电磁感应测量在水文地质调查中的应用波兰案例研究
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0092
S. Oryński, M. Okoń, W. Klityński
In 2011, a geophysical survey was carried out in the surroundings of the Jagiellonian University in Cracow, using a Very Low Frequency method. The measurements were designed to determine the reason of frequent flooding of the lowest level of the building. The main objective of the study was to find out from where and in which way the rainwater seeps into the building and how this problem can be solved in the least invasive manner. The aim of geophysical methods was also to provide necessary information that will enable the construction of a hydro-geological model of the local environment. The interpretation revealed the presence of a sandy gutter surrounded by impermeable clay. There is a big resistivity contrast between those layers. Their location and approximate dimensions were determined.
2011年,在克拉科夫的雅盖隆大学周围进行了一次地球物理调查,使用了甚低频方法。测量的目的是确定建筑物最底层经常被洪水淹没的原因。该研究的主要目的是找出雨水从哪里以及以何种方式渗入建筑,以及如何以最小的侵入方式解决这个问题。地球物理方法的目的还在于提供必要的资料,以便能够建立当地环境的水文地质模型。这一解释揭示了被不透水粘土包围的沙质沟渠的存在。这些层之间的电阻率差异很大。确定了它们的位置和大致尺寸。
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引用次数: 4
Analysis of Coseismic Fault Slip Models of the 2012 Indian Ocean Earthquake: Importance of GPS Data for Crustal Deformation Studies 2012年印度洋地震同震断层滑动模型分析:GPS数据对地壳形变研究的重要性
IF 2.3 4区 地球科学 Q2 GEOCHEMISTRY & GEOPHYSICS Pub Date : 2016-12-28 DOI: 10.1515/acgeo-2016-0106
E. Gunawan, P. Maulida, I. Meilano, M. Irsyam, J. Efendi
Based on continuous GPS data, we analyze coseismic deformation due to the 2012 Indian Ocean earthquake. We use the available coseismic slip models of the 2012 earthquake, derived from geodetic and/or seismic waveform inversion, to calculate the coseismic displacements in the Andaman-Nicobar, Sumatra and Java. In our analysis, we employ a spherical, layered model of the Earth and we find that Java Island experienced coseismic displacements up to 8 mm, as also observed by our GPS network. Compared to coseismic offsets measured from GPS data, a coseismic slip model derived from multiple observations produced better results than a model based on a single type of observation.
基于连续GPS数据,对2012年印度洋地震的同震形变进行了分析。我们利用2012年地震的同震滑动模型,通过大地测量和/或地震波形反演,计算了安达曼-尼科巴、苏门答腊和爪哇的同震位移。在我们的分析中,我们采用了地球的球形分层模型,我们发现爪哇岛经历了高达8毫米的同震位移,正如我们的GPS网络所观察到的那样。与GPS数据测量的同震偏移量相比,由多次观测得出的同震滑动模型比基于单一类型观测的模型产生更好的结果。
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引用次数: 16
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Acta Geophysica
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