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An Overview of Cone-Beam Computed Tomography and Dental Panoramic Radiography in Dentistry in the Community. 社区牙科中的锥形束计算机断层扫描和牙科全景放射摄影概述。
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-07 DOI: 10.3390/tomography10080092
David MacDonald, Vera Telyakova

This study reviews the two most important and frequently used systems of tomography used in dentistry today. These are the dental panoramic radiograph (DPR) and cone-beam computed tomography (CBCT). The importance of the DPR has been accentuated by the recent COVID-19 pandemic, as it does not produce an aerosol. Its clinical importance is derived from its panoramic display of the jaws and associated structures and should be examined for incidental findings that may portend a potentially serious outcome. An important recent spin-off of the DPR is the extra-oral bitewing, which can replace its traditional, uncomfortable and aerosol-generating intra-oral counterpart. Although much has been written about them, this paper reviews their essential attributes and limitations in clinical dentistry. Although attempts have been made to reproduce some of the attributes of CT in CBCT such as Hounsfield Units (HU) and improve the contrast resolution of the soft tissues, these remain elusive. Nevertheless, CBCT's dataset should be appropriately reconstructed to fully display the clinical feature prompting its prescription. In certain cases, more than one mode of reconstruction is required.

本研究回顾了当今牙科领域最重要、最常用的两种断层成像系统。这两种系统分别是牙科全景放射摄影 (DPR) 和锥形束计算机断层扫描 (CBCT)。由于 DPR 不会产生气溶胶,因此最近的 COVID-19 大流行更加凸显了它的重要性。其临床重要性来自于它对颌骨和相关结构的全景显示,应检查是否有可能预示潜在严重后果的偶然发现。口外咬合显微镜是 DPR 最近的一个重要衍生产品,它可以取代传统的、不舒适的、会产生气溶胶的口内咬合显微镜。虽然关于它们的文章已经很多,但本文还是要回顾一下它们在临床牙科中的基本特性和局限性。尽管人们已经尝试在 CBCT 中复制 CT 的某些特性,如 HU(Hounsfield Units)和提高软组织的对比分辨率,但这些仍然难以实现。尽管如此,CBCT 的数据集仍应进行适当的重建,以充分显示临床特征,从而开出处方。在某些情况下,需要一种以上的重建模式。
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引用次数: 0
Novel Deep CNNs Explore Regions, Boundaries, and Residual Learning for COVID-19 Infection Analysis in Lung CT. 新型深度 CNN 探索区域、边界和残余学习,用于肺部 CT 中的 COVID-19 感染分析。
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-03 DOI: 10.3390/tomography10080091
Bader Khalid Alshemaimri

COVID-19 poses a global health crisis, necessitating precise diagnostic methods for timely containment. However, accurately delineating COVID-19-affected regions in lung CT scans is challenging due to contrast variations and significant texture diversity. In this regard, this study introduces a novel two-stage classification and segmentation CNN approach for COVID-19 lung radiological pattern analysis. A novel Residual-BRNet is developed to integrate boundary and regional operations with residual learning, capturing key COVID-19 radiological homogeneous regions, texture variations, and structural contrast patterns in the classification stage. Subsequently, infectious CT images undergo lesion segmentation using the newly proposed RESeg segmentation CNN in the second stage. The RESeg leverages both average and max-pooling implementations to simultaneously learn region homogeneity and boundary-related patterns. Furthermore, novel pixel attention (PA) blocks are integrated into RESeg to effectively address mildly COVID-19-infected regions. The evaluation of the proposed Residual-BRNet CNN in the classification stage demonstrates promising performance metrics, achieving an accuracy of 97.97%, F1-score of 98.01%, sensitivity of 98.42%, and MCC of 96.81%. Meanwhile, PA-RESeg in the segmentation phase achieves an optimal segmentation performance with an IoU score of 98.43% and a dice similarity score of 95.96% of the lesion region. The framework's effectiveness in detecting and segmenting COVID-19 lesions highlights its potential for clinical applications.

COVID-19 带来了全球性的健康危机,需要精确的诊断方法来及时遏制。然而,由于对比度的变化和纹理的显著多样性,在肺部 CT 扫描中准确划分 COVID-19 影响区域具有挑战性。为此,本研究引入了一种新颖的两阶段分类和分割 CNN 方法,用于 COVID-19 肺部放射模式分析。研究人员开发了一种新颖的残差-BRNet,将边界和区域操作与残差学习相结合,在分类阶段捕捉 COVID-19 放射学的关键同质区域、纹理变化和结构对比模式。随后,在第二阶段使用新提出的 RESeg 分割 CNN 对感染性 CT 图像进行病变分割。RESeg 利用平均和最大池化实现同时学习区域同质性和边界相关模式。此外,RESeg 中还集成了新的像素关注 (PA) 块,以有效处理轻度 COVID-19 感染区域。在分类阶段,对所提出的残差-BRNet CNN 的评估显示出了良好的性能指标,其准确率达到了 97.97%,F1 分数为 98.01%,灵敏度为 98.42%,MCC 为 96.81%。同时,PA-RESeg 在分割阶段实现了最佳分割性能,病变区域的 IoU 得分为 98.43%,骰子相似度得分为 95.96%。该框架在检测和分割 COVID-19 病变方面的有效性凸显了其在临床应用中的潜力。
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引用次数: 0
A Review of 3D Modalities Used for the Diagnosis of Scoliosis. 用于诊断脊柱侧弯的 3D 模式综述。
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-02 DOI: 10.3390/tomography10080090
Sampath Kumar, Bhaskar Awadhiya, Rahul Ratnakumar, Ananthakrishna Thalengala, Anu Shaju Areeckal, Yashwanth Nanjappa

Spine radiographs in the standing position are the recommended standard for diagnosing idiopathic scoliosis. Though the deformity exists in 3D, its diagnosis is currently carried out with the help of 2D radiographs due to the unavailability of an efficient, low-cost 3D alternative. Computed tomography (CT) and magnetic resonance imaging (MRI) are not suitable in this case, as they are obtained in the supine position. Research on 3D modelling of scoliotic spine began with multiplanar radiographs and later moved on to biplanar radiographs and finally a single radiograph. Nonetheless, modern advances in diagnostic imaging have the potential to preserve image quality and decrease radiation exposure. They include the DIERS formetric scanner system, the EOS imaging system, and ultrasonography. This review article briefly explains the technology behind each of these methods. They are compared with the standard imaging techniques. The DIERS system and ultrasonography are radiation free but have limitations with respect to the quality of the 3D model obtained. There is a need for 3D imaging technology with less or zero radiation exposure and that can produce a quality 3D model for diseases like adolescent idiopathic scoliosis. Accurate 3D models are crucial in clinical practice for diagnosis, planning surgery, patient follow-up examinations, biomechanical applications, and computer-assisted surgery.

立位脊柱X光片是诊断特发性脊柱侧弯的推荐标准。虽然脊柱畸形存在于三维空间中,但由于缺乏高效、低成本的三维替代方法,目前只能借助二维X光片进行诊断。计算机断层扫描(CT)和核磁共振成像(MRI)在这种情况下并不适用,因为它们都是在仰卧姿势下获得的。脊柱侧弯的三维建模研究始于多平面射线照片,后来发展到双平面射线照片,最后发展到单张射线照片。然而,现代诊断成像技术的进步有可能保持图像质量并减少辐射暴露。这些技术包括 DIERS 成形扫描系统、EOS 成像系统和超声波成像技术。这篇综述文章简要介绍了这些方法背后的技术。并将它们与标准成像技术进行比较。DIERS 系统和超声波成像技术无辐射,但在获得三维模型的质量方面有局限性。我们需要辐射较少或为零的三维成像技术,并能为青少年特发性脊柱侧凸等疾病生成高质量的三维模型。在临床实践中,精确的三维模型对诊断、手术规划、患者随访检查、生物力学应用和计算机辅助手术至关重要。
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引用次数: 0
A Novel and Reliable Pixel Response Correction Method (DAC-Shifting) for Spectral Photon-Counting CT Imaging. 用于光谱光子计数 CT 成像的新颖可靠的像素响应校正方法(DAC-Shifting)。
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-22 DOI: 10.3390/tomography10070089
Navrit Johan Singh Bal, Imaiyan Chitra Ragupathy, Trine Tramm, Jasper Nijkamp

Spectral photon-counting cone-beam computed tomography (CT) imaging is challenged by individual pixel response behaviours, which lead to noisy projection images and subsequent image artefacts like rings. Existing methods to correct for this either use calibration measurements, like signal-to-thickness calibration (STC), or perform a post-processing ring artefact correction of sinogram data or scan reconstructions without taking the pixel response explicitly into account. Here, we present a novel post-processing method (digital-to-analogue converter (DAC)-shifting) which explicitly measures the current pixel response using flat-field images and subsequently corrects the projection data. The DAC-shifting method was evaluated using a repeat series of the spectral photon-counting imaging (Medipix3) of a phantom with different density inserts and iodine K-edge imaging. The method was also compared against polymethyl methacrylate (PMMA)-based STC. The DAC-shifting method was shown to be effective in correcting individual pixel responses and was robust against detector instability; it led to a 47.4% average reduction in CT-number variation in homogeneous materials, with a range of 40.7-55.6%. On the contrary, the STC correction showed varying results; a 13.7% average reduction in CT-number variation, ranging from a 43.7% increase to a 45.5% reduction. In K-edge imaging, DAC-shifting provides a sharper attenuation peak and more uniform CT values, which are expected to benefit iodine concentration quantifications.

光谱光子计数锥形束计算机断层扫描(CT)成像面临着单个像素响应行为的挑战,这会导致投影图像产生噪声和随后的图像伪影(如环)。现有的校正方法要么使用校准测量(如信号-厚度校准(STC)),要么对正弦曲线数据或扫描重建进行后处理环形伪影校正,而不明确考虑像素响应。在这里,我们提出了一种新颖的后处理方法(数模转换器(DAC)移位),该方法利用平场图像明确测量当前的像素响应,然后对投影数据进行校正。使用不同密度插入物和碘 K 边成像的重复系列幻影光谱光子计数成像(Medipix3)对 DAC 移位方法进行了评估。该方法还与基于聚甲基丙烯酸甲酯(PMMA)的 STC 进行了比较。结果表明,DAC 移位法能有效校正单个像素的响应,并能抵御探测器的不稳定性;在均质材料中,它能使 CT 数变化平均减少 47.4%,减少范围为 40.7-55.6%。相反,STC 校正显示出不同的结果;CT 数变化平均减少 13.7%,范围从增加 43.7% 到减少 45.5%。在 K 边成像中,DAC 移位提供了更清晰的衰减峰值和更均匀的 CT 值,预计这将有利于碘浓度的量化。
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引用次数: 0
The Incidence and Characteristics of Pelvic-Origin Varicosities in Patients with Complex Varices Evaluated by Ultrasonography. 通过超声波检查评估复杂静脉曲张患者盆腔源性静脉曲张的发病率和特征。
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-19 DOI: 10.3390/tomography10070088
Kwon Cheol Yoo, Hyung Sub Park, Chang Sik Shin, Taeseung Lee

Objective: The purpose of this study was to evaluate the incidence of gonadal vein refluxes associated with lower-extremity varicose veins with Doppler ultrasonography (DUS).

Method: A total of 6279 patients with venous disease-related symptoms of the lower extremity were evaluated with DUS in the vascular lab. Gonadal vein reflux using abdominal ultrasound was further evaluated in patients with unusual varices, defined as varices in the inguinal, inner or upper thigh and the vulvar area without refluxes in the saphenofemoral junction (SPJ). Those patients who showed gonadal vein reflux were diagnosed as having pelvic-origin varicosity.

Results: Unusual varices were found in a total of 237 patients (3.8%), and of these patients, pelvic-origin varicosity was discovered with transabdominal ultrasound in 156 (65.8%). A total of 66.7% (n = 38/57) of unusual varix patients with pelvic pain had gonadal vein reflux. The measurement of gonadal vein diameter was larger in ultrasonography than CT scans (8.835 vs. 8.81, p < 0.001). Two patients with severe symptoms but no obstructive venous diseases were treated with gonadal vein embolization.

Conclusion: The incidence of pelvic-origin varicosities was 2.5% (n = 156/6279). However, more than half of the patients with unusual varices had gonadal vein reflux and 24.4% of these patients also presented with pelvic pain. The evaluation of pelvic-origin varicosities should be performed in patients who present with unusual forms of varices of the lower extremity.

研究目的本研究旨在通过多普勒超声(DUS)评估与下肢静脉曲张相关的性腺静脉回流的发生率:方法:血管实验室共对 6279 名有下肢静脉疾病相关症状的患者进行了 DUS 评估。对有异常静脉曲张的患者使用腹部超声进一步评估性腺静脉回流情况,异常静脉曲张的定义是腹股沟、大腿内侧或上部以及外阴区域的静脉曲张,但隐股沟交界处(SPJ)无回流。出现性腺静脉反流的患者被诊断为盆腔源性静脉曲张:结果:共有 237 名患者(3.8%)发现异常静脉曲张,其中 156 名患者(65.8%)经腹部超声检查发现患有盆腔静脉曲张。在伴有盆腔疼痛的异常静脉曲张患者中,共有 66.7%(38/57)的患者伴有性腺静脉回流。与 CT 扫描相比,超声波检查测量的性腺静脉直径更大(8.835 对 8.81,P < 0.001)。两名症状严重但无阻塞性静脉疾病的患者接受了性腺静脉栓塞治疗:结论:盆腔静脉曲张的发病率为 2.5%(n = 156/6279)。结论:盆腔源性静脉曲张的发病率为 2.5%(n = 156/6279),但超过一半的异常静脉曲张患者伴有性腺静脉回流,其中 24.4% 的患者还伴有盆腔疼痛。对于出现下肢静脉曲张异常的患者,应进行盆腔静脉曲张评估。
{"title":"The Incidence and Characteristics of Pelvic-Origin Varicosities in Patients with Complex Varices Evaluated by Ultrasonography.","authors":"Kwon Cheol Yoo, Hyung Sub Park, Chang Sik Shin, Taeseung Lee","doi":"10.3390/tomography10070088","DOIUrl":"10.3390/tomography10070088","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to evaluate the incidence of gonadal vein refluxes associated with lower-extremity varicose veins with Doppler ultrasonography (DUS).</p><p><strong>Method: </strong>A total of 6279 patients with venous disease-related symptoms of the lower extremity were evaluated with DUS in the vascular lab. Gonadal vein reflux using abdominal ultrasound was further evaluated in patients with unusual varices, defined as varices in the inguinal, inner or upper thigh and the vulvar area without refluxes in the saphenofemoral junction (SPJ). Those patients who showed gonadal vein reflux were diagnosed as having pelvic-origin varicosity.</p><p><strong>Results: </strong>Unusual varices were found in a total of 237 patients (3.8%), and of these patients, pelvic-origin varicosity was discovered with transabdominal ultrasound in 156 (65.8%). A total of 66.7% (n = 38/57) of unusual varix patients with pelvic pain had gonadal vein reflux. The measurement of gonadal vein diameter was larger in ultrasonography than CT scans (8.835 vs. 8.81, <i>p</i> < 0.001). Two patients with severe symptoms but no obstructive venous diseases were treated with gonadal vein embolization.</p><p><strong>Conclusion: </strong>The incidence of pelvic-origin varicosities was 2.5% (n = 156/6279). However, more than half of the patients with unusual varices had gonadal vein reflux and 24.4% of these patients also presented with pelvic pain. The evaluation of pelvic-origin varicosities should be performed in patients who present with unusual forms of varices of the lower extremity.</p>","PeriodicalId":51330,"journal":{"name":"Tomography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11280516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automatically Detecting Pancreatic Cysts in Autosomal Dominant Polycystic Kidney Disease on MRI Using Deep Learning 利用深度学习在核磁共振成像上自动检测常染色体显性多囊肾病的胰腺囊肿
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-16 DOI: 10.3390/tomography10070087
Sophie J. Wang, Zhongxiu Hu, Collin Li, Xinzi He, Chenglin Zhu, Yin Wang, Usama Sattar, Vahid Bazojoo, Hui Yi Ng He, Jon D. Blumenfeld, Martin R. Prince
Background: Pancreatic cysts in autosomal dominant polycystic kidney disease (ADPKD) correlate with PKD2 mutations, which have a different phenotype than PKD1 mutations. However, pancreatic cysts are commonly overlooked by radiologists. Here, we automate the detection of pancreatic cysts on abdominal MRI in ADPKD. Methods: Eight nnU-Net-based segmentation models with 2D or 3D configuration and various loss functions were trained on positive-only or positive-and-negative datasets, comprising axial and coronal T2-weighted MR images from 254 scans on 146 ADPKD patients with pancreatic cysts labeled independently by two radiologists. Model performance was evaluated on test subjects unseen in training, comprising 40 internal, 40 external, and 23 test–retest reproducibility ADPKD patients. Results: Two radiologists agreed on 52% of cysts labeled on training data, and 33%/25% on internal/external test datasets. The 2D model with a loss of combined dice similarity coefficient and cross-entropy trained with the dataset with both positive and negative cases produced an optimal dice score of 0.7 ± 0.5/0.8 ± 0.4 at the voxel level on internal/external validation and was thus used as the best-performing model. In the test–retest, the optimal model showed superior reproducibility (83% agreement between scan A and B) in segmenting pancreatic cysts compared to six expert observers (77% agreement). In the internal/external validation, the optimal model showed high specificity of 94%/100% but limited sensitivity of 20%/24%. Conclusions: Labeling pancreatic cysts on T2 images of the abdomen in patients with ADPKD is challenging, deep learning can help the automated detection of pancreatic cysts, and further image quality improvement is warranted.
背景:常染色体显性多囊肾病(ADPKD)中的胰腺囊肿与 PKD2 基因突变有关,后者的表型与 PKD1 基因突变不同。然而,胰腺囊肿通常会被放射科医生忽视。在此,我们将自动检测 ADPKD 患者腹部 MRI 上的胰腺囊肿。方法:基于 nnU-Net 的八种二维或三维分割模型和各种损失函数在仅阳性或阳性加阴性数据集上进行了训练,这些数据集包括对 146 名 ADPKD 患者进行的 254 次扫描中的轴向和冠状 T2 加权 MR 图像,其中的胰腺囊肿由两名放射科医生独立标记。模型性能在训练中未见的测试对象上进行了评估,这些测试对象包括 40 名内部、40 名外部和 23 名测试-重复再现性 ADPKD 患者。结果:两位放射科医生对训练数据中52%的囊肿标记和内部/外部测试数据集中33%/25%的囊肿标记达成了一致。在内部/外部验证中,使用包含阳性和阴性病例的数据集训练的具有综合骰子相似系数和交叉熵损失的二维模型在体素水平上产生的最佳骰子分数为 0.7 ± 0.5/0.8 ± 0.4,因此被用作表现最佳的模型。在重复测试中,与六位专家观察员(77% 的一致性)相比,最佳模型在分割胰腺囊肿方面显示出更高的重现性(扫描 A 和扫描 B 之间的一致性为 83%)。在内部/外部验证中,最佳模型显示出 94%/100% 的高特异性,但灵敏度有限,仅为 20%/24%。结论在 ADPKD 患者的腹部 T2 图像上标记胰腺囊肿具有挑战性,深度学习可帮助自动检测胰腺囊肿,因此有必要进一步提高图像质量。
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引用次数: 0
Computed Tomography Angiography as Ancillary Testing for Death Determination by Neurologic Criteria: A Technical Review 计算机断层扫描血管造影作为根据神经学标准判定死亡的辅助检查:技术回顾
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-16 DOI: 10.3390/tomography10070086
A. Aziz Rizk, Jai Shankar
The determination of death by neurological criteria (DNC) stands as a pivotal aspect of medical practice, involving a nuanced clinical diagnosis. Typically, it comes into play following a devastating brain injury, signalling the irreversible cessation of brain function, marked by the absence of consciousness, brainstem reflexes, and the ability to breathe autonomously. Accurate DNC diagnosis is paramount for adhering to the ‘Dead donor rule’, which permits organ donation solely from deceased individuals. However, complexities inherent in conducting a comprehensive DNC examination may impede reaching a definitive diagnosis. To address this challenge, ancillary testing such as computed tomography angiography (CTA) has emerged as a valuable tool. The aim of our study is to review the technique and interpretation of CTA for DNC diagnoses. CTA, a readily available imaging technique, enables visualization of the cerebral vasculature, offering insights into blood flow to the brain. While various criteria and scoring systems have been proposed, a universally accepted standard for demonstrating full brain circulatory arrest remains elusive. Nonetheless, leveraging CTA as an ancillary test in DNC assessments holds promise, facilitating organ donation and curbing healthcare costs. It is crucial to emphasize that DNC diagnosis should be exclusively entrusted to trained physicians with specialized DNC evaluation training, underscoring the importance of expertise in this intricate medical domain.
按神经学标准判定死亡(DNC)是医疗实践中的一个关键环节,涉及细致入微的临床诊断。通常情况下,它在破坏性脑损伤后发挥作用,标志着大脑功能不可逆转的停止,表现为意识、脑干反射和自主呼吸能力的缺失。准确的 DNC 诊断对于遵守 "死亡捐献者规则 "至关重要,该规则只允许从已故者身上捐献器官。然而,进行全面的 DNC 检查所固有的复杂性可能会阻碍做出明确诊断。为了应对这一挑战,计算机断层扫描血管造影术(CTA)等辅助检查已成为一种有价值的工具。我们的研究旨在回顾 CTA 诊断 DNC 的技术和解释。CTA 是一种现成的成像技术,可对脑血管进行可视化检查,从而深入了解脑血流情况。虽然已经提出了各种标准和评分系统,但仍无法找到一个普遍接受的标准来证明脑循环完全停止。尽管如此,利用 CTA 作为 DNC 评估的辅助检查仍有希望促进器官捐献并降低医疗成本。必须强调的是,DNC 诊断应完全委托给受过专门 DNC 评估培训的医生,这凸显了专业知识在这一错综复杂的医学领域的重要性。
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引用次数: 0
Joint k-ω Space Image Reconstruction and Data Fitting for Chemical Exchange Saturation Transfer Magnetic Resonance Imaging 化学交换饱和转移磁共振成像的联合 k-ω 空间图像重建和数据拟合
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-15 DOI: 10.3390/tomography10070085
Yuting Peng, Yan Dai, Shu Zhang, Jie Deng, Xun Jia
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is a novel MRI technology to image certain compounds at extremely low concentrations. Long acquisition time to measure signals at a set of offset frequencies of the Z-spectra and to repeat measurements to reduce noise pose significant challenges to its applications. This study explores correlations of CEST MR images along the spatial and Z-spectral dimensions to improve MR image quality and robustness of magnetization transfer ratio (MTR) asymmetry estimation via a joint k-ω reconstruction model. The model was formulated as an optimization problem with respect to MR images at all frequencies ω, while incorporating regularizations along the spatial and spectral dimensions. The solution was subject to a self-consistency condition that the Z-spectrum of each pixel follows a multi-peak data fitting model corresponding to different CEST pools. The optimization problem was solved using the alternating direction method of multipliers. The proposed joint reconstruction method was evaluated on a simulated CEST MRI phantom and semi-experimentally on choline and iopamidol phantoms with added Gaussian noise of various levels. Results demonstrated that the joint reconstruction method was more tolerable to noise and reduction in number of offset frequencies by improving signal-to-noise ratio (SNR) of the reconstructed images and reducing uncertainty in MTR asymmetry estimation. In the choline and iopamidol phantom cases with 10.5% noise in the measurement data, our method achieved an averaged SNR of 31.0 dB and 32.2 dB compared to the SNR of 24.7 dB and 24.4 dB in the conventional reconstruction approach. It reduced uncertainty of the MTR asymmetry estimation over all regions of interest by 54.4% and 43.7%, from 1.71 and 2.38 to 0.78 and 1.71, respectively.
化学交换饱和转移(CEST)磁共振成像(MRI)是一种新型磁共振成像技术,可对浓度极低的某些化合物进行成像。在一组偏移频率的 Z 光谱上测量信号和重复测量以降低噪声所需的采集时间较长,这给其应用带来了巨大挑战。本研究探讨了 CEST 磁共振图像在空间和 Z 光谱维度上的相关性,以通过联合 k-ω 重建模型提高磁共振图像质量和磁化传递比(MTR)不对称估计的稳健性。该模型被表述为一个与所有频率ω的磁共振图像相关的优化问题,同时包含了空间和频谱维度的正则化。求解时需要满足一个自洽条件,即每个像素的 Z 频谱都遵循与不同 CEST 池相对应的多峰数据拟合模型。优化问题使用乘数交替法求解。在模拟 CEST 磁共振成像模型上对所提出的联合重建方法进行了评估,并在添加了不同程度高斯噪声的胆碱和碘帕米多模型上进行了半实验性评估。结果表明,通过提高重建图像的信噪比(SNR)和降低 MTR 不对称估计的不确定性,联合重建方法对噪声和偏移频率数量的减少更有耐受性。在胆碱和碘帕米多模型中,测量数据的噪声为 10.5%,与传统重建方法的信噪比 24.7 dB 和 24.4 dB 相比,我们的方法实现了 31.0 dB 和 32.2 dB 的平均信噪比。它将所有相关区域的 MTR 不对称估计的不确定性分别从 1.71 和 2.38 降至 0.78 和 1.71,降幅分别为 54.4% 和 43.7%。
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引用次数: 0
Collagen 1 Fiber Volume Predicts for Recurrence of Stage 1 Non-Small Cell Lung Cancer 胶原蛋白 1 纤维量预测非小细胞肺癌 1 期复发率
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-13 DOI: 10.3390/tomography10070083
S. Kakkad, B. Krishnamachary, Nadege Fackche, Matthew Garner, Malcom Brock, Peng Huang, Z. Bhujwalla
Background: The standard of care for stage 1 NSCLC is upfront surgery followed by surveillance. However, 20–30% of stage 1 NSCLC recur. There is an unmet need to identify individuals likely to recur who would benefit from frequent monitoring and aggressive cancer treatments. Collagen 1 (Col1) fibers detected by second harmonic generation (SHG) microscopy are a major structural component of the extracellular matrix (ECM) of tumors that play a role in cancer progression. Method: We characterized Col1 fibers with SHG microscopy imaging of surgically resected stage 1 NSCLC. Gene expression from RNA sequencing data was used to validate the SHG microscopy findings. Results: We identified a significant (p ≤ 0.05) increase in the Col1 fiber volume in stage 1 NSCLC that recurred. The increase in Col1 fiber volume was supported by significant increases in the gene expression of Col1 in invasive, compared to noninvasive, lung adenocarcinoma. Significant differences were identified in the gene expression of other ECM proteins, as well as CAFs, immune checkpoint markers, immune cytokines, and T-cell markers. Conclusion: Col1 fiber analysis can provide a companion diagnostic test to evaluate the likelihood of tumor recurrence following stage 1 NSCLC. The studies expand our understanding of the role of the ECM in NSCLC recurrence.
背景:一期非小细胞肺癌的标准治疗方法是先进行手术,然后进行监测。然而,20%-30%的一期 NSCLC 会复发。识别可能复发的患者是一项尚未满足的需求,这些患者将受益于频繁的监测和积极的癌症治疗。通过二次谐波发生(SHG)显微镜检测到的胶原蛋白1(Col1)纤维是肿瘤细胞外基质(ECM)的主要结构成分,在癌症进展中发挥着作用。我们的方法是我们利用 SHG 显微镜对手术切除的 1 期 NSCLC 进行成像,以确定 Col1 纤维的特征。利用 RNA 测序数据中的基因表达来验证 SHG 显微镜的发现。结果:我们发现在复发的一期 NSCLC 中,Col1 纤维体积明显增加(p ≤ 0.05)。与非浸润性肺腺癌相比,浸润性肺腺癌中 Col1 的基因表达明显增加,这也支持了 Col1 纤维体积的增加。其他 ECM 蛋白、CAFs、免疫检查点标记物、免疫细胞因子和 T 细胞标记物的基因表达也存在显著差异。结论Col1 纤维分析可作为一种辅助诊断测试,用于评估 1 期 NSCLC 后肿瘤复发的可能性。这些研究拓展了我们对 ECM 在 NSCLC 复发中的作用的认识。
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引用次数: 0
Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification 用于冠状动脉血管造影和全心肌灌注定量的超极化水
IF 2.2 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-13 DOI: 10.3390/tomography10070084
Yupeng Zhao, M. Lerche, Magnus Karlsson, R. Olin, E. Hansen, Malene Aastrup, Mohsen Redda, C. Laustsen, Lars G. Hanson, J. Ardenkjær-Larsen
Purpose: Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. Methods: 1H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for 15O water PET from the literature. Results: A liquid state polarization of 10% at the time of the injection and a 30 s T1 in D2O TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for 15O-water PET (around 1.1 and 1.5 mL/g/min). Conclusion: The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.
目的:水可在细胞膜上自由扩散,因此适合测量组织的绝对灌注量。在本研究中,我们介绍了一种利用超极化水进行冠状动脉造影和量化整个心脏心肌灌注的成像方法。方法:利用紫外线产生的自由基通过溶解动态核极化(dDNP)对 1H 进行超极化。使用在舒张期选通的破坏 GRE(SPGRE)序列获取亚毫米分辨率的冠状动脉二维投影图像。动态血流灌注图像是通过多切片 SPGRE 获得的,该序列在舒张期选通,覆盖整个心脏。通过直方图分析灌注值,并将最常见的估计灌注值(分布模式)与文献中 15O 水 PET 的平均值进行比较。结果:注射时的液态极化为 10%,在 D2O TRIS 缓冲液中的 T1 为 30 秒。冠状动脉图像和动态灌注图像均显示出良好的质量。冠状动脉主干和细小分支均清晰分辨。最常见的估计灌注值约为 0.6 mL/g/min,低于文献中 15O 水 PET 的平均值(约为 1.1 和 1.5 mL/g/min)。结论该研究成功证明了使用超极化水实现高分辨率、无运动冠状动脉血管造影和三维全心定量心肌灌注的可行性。
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