Pub Date : 2025-09-30DOI: 10.1016/j.jdsr.2025.09.002
Victor Melo-Soares, Andréa Cândido dos Reis, Mariana Lima da Costa Valente
Introduction
Polymethyl methacrylate (PMMA) resins are widely used in dental prostheses due to their excellent physical, mechanical, and aesthetic properties. However, their susceptibility to microbial colonization can compromise oral and systemic health. Titanium dioxide (TiO₂), with its photocatalytic activity, has gained attention for its antimicrobial potential. This systematic review investigates how the physicochemical properties of TiO₂ affect its antimicrobial efficacy in PMMA-TiO₂ composites, aiming to optimize their performance and clinical effectiveness.
Methods
PubMed, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and ProQuest were searched in October 2024. Articles were selected in two stages by two blinded researchers based on predefined eligibility criteria. Risk of bias was assessed using the RobDEMAT tool.
Results
A comprehensive search identified 1464 articles, which were screened by title and abstract according to inclusion criteria. Of the 28 studies selected for full-text review, 24 were included in this systematic review, all of which were in vitro studies. Due to the high heterogeneity of the selected studies, which prevented statistical analysis of the data, a descriptive analysis was performed.
Conclusions
The balance between concentration, size, crystallinity, and surface morphology can enhance TiO₂ photocatalytic activity and reduce microbial adhesion. Synthesis and functionalization strategies can overcome limitations, expanding the clinical applicability, efficiency, and durability of PMMA-TiO₂ composites.
聚甲基丙烯酸甲酯（PMMA）树脂因其优异的物理、机械和美学性能而广泛应用于口腔修复中。然而，他们对微生物定植的易感性会损害口腔和全身健康。二氧化钛（TiO 2）具有光催化活性，其抗菌潜力备受关注。本文研究了二氧化钛在pmma -二氧化钛复合材料中的理化性质对其抗菌效果的影响，旨在优化其性能和临床效果。方法于2024年10月检索spubmed、Embase、Scopus、ScienceDirect、Web of Science、谷歌Scholar和ProQuest。两名盲法研究人员根据预先确定的资格标准，分两个阶段选择文章。使用RobDEMAT工具评估偏倚风险。结果综合检索到文献1464篇，根据纳入标准按标题和摘要筛选。在入选全文综述的28项研究中，有24项纳入了本系统综述，均为体外研究。由于所选研究的高度异质性，这阻碍了数据的统计分析，因此进行了描述性分析。结论浓度、粒径、结晶度和表面形貌之间的平衡可以提高tio2光催化活性，减少微生物粘附。合成和功能化策略可以克服局限性，扩大PMMA-TiO 2复合材料的临床适用性，效率和耐久性。
{"title":"Optimizing titanium dioxide-functionalized polymethyl methacrylate (PMMA-TiO₂) for dental applications: A systematic review on physicochemical parameters and antimicrobial outcomes","authors":"Victor Melo-Soares, Andréa Cândido dos Reis, Mariana Lima da Costa Valente","doi":"10.1016/j.jdsr.2025.09.002","DOIUrl":"10.1016/j.jdsr.2025.09.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Polymethyl methacrylate (PMMA) resins are widely used in dental prostheses due to their excellent physical, mechanical, and aesthetic properties. However, their susceptibility to microbial colonization can compromise oral and systemic health. Titanium dioxide (TiO₂), with its photocatalytic activity, has gained attention for its antimicrobial potential. This systematic review investigates how the physicochemical properties of TiO₂ affect its antimicrobial efficacy in PMMA-TiO₂ composites, aiming to optimize their performance and clinical effectiveness.</div></div><div><h3>Methods</h3><div>PubMed, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and ProQuest were searched in October 2024. Articles were selected in two stages by two blinded researchers based on predefined eligibility criteria. Risk of bias was assessed using the RobDEMAT tool.</div></div><div><h3>Results</h3><div>A comprehensive search identified 1464 articles, which were screened by title and abstract according to inclusion criteria. Of the 28 studies selected for full-text review, 24 were included in this systematic review, all of which were in vitro studies. Due to the high heterogeneity of the selected studies, which prevented statistical analysis of the data, a descriptive analysis was performed.</div></div><div><h3>Conclusions</h3><div>The balance between concentration, size, crystallinity, and surface morphology can enhance TiO₂ photocatalytic activity and reduce microbial adhesion. Synthesis and functionalization strategies can overcome limitations, expanding the clinical applicability, efficiency, and durability of PMMA-TiO₂ composites.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 236-249"},"PeriodicalIF":6.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This systematic review and meta-analysis evaluated the effectiveness of temporomandibular joint (TMJ) mobilization in individuals with temporomandibular disorders (TMDs), using data from randomized controlled trials (RCTs) and before-after studies without control groups. Human studies assessing outcomes, including muscle activity, pain intensity, oral and cervical range of motion, and self-reported measures before and after mobilization, and comparing these results with those of individuals who received other conventional TMD treatments, were considered. Study selection and data extraction were performed by two independent reviewers, with a third reviewer resolving any disagreements. Of the 652 studies identified, five met the inclusion criteria. The evidence shows improvements in pain intensity, range of motion, and other patient-reported outcomes, following TMJ mobilization. These effects were observed immediately after treatment, showed a slight decrease at one week, and were further enhanced at four weeks. Compared to the control group, our meta-analyses demonstrate a significant reduction in pain intensity (mean difference = −2.90) and a significant improvement in mouth opening (mean difference = 10.76) at four weeks post-mobilization. The findings indicate that TMJ mobilization may serve as an effective short-term intervention for managing TMD, especially in the initial stages of treatment. However, further RCTs with long-term follow-up are warranted.
{"title":"The effectiveness of mobilization in treating patients with temporomandibular disorders: A systematic review and meta-analysis","authors":"Prangtip Potewiratnanond , Sudaporn Pummoung , Chidsanu Changsiripun","doi":"10.1016/j.jdsr.2025.09.001","DOIUrl":"10.1016/j.jdsr.2025.09.001","url":null,"abstract":"<div><div>This systematic review and meta-analysis evaluated the effectiveness of temporomandibular joint (TMJ) mobilization in individuals with temporomandibular disorders (TMDs), using data from randomized controlled trials (RCTs) and before-after studies without control groups. Human studies assessing outcomes, including muscle activity, pain intensity, oral and cervical range of motion, and self-reported measures before and after mobilization, and comparing these results with those of individuals who received other conventional TMD treatments, were considered. Study selection and data extraction were performed by two independent reviewers, with a third reviewer resolving any disagreements. Of the 652 studies identified, five met the inclusion criteria. The evidence shows improvements in pain intensity, range of motion, and other patient-reported outcomes, following TMJ mobilization. These effects were observed immediately after treatment, showed a slight decrease at one week, and were further enhanced at four weeks. Compared to the control group, our meta-analyses demonstrate a significant reduction in pain intensity (mean difference = −2.90) and a significant improvement in mouth opening (mean difference = 10.76) at four weeks post-mobilization. The findings indicate that TMJ mobilization may serve as an effective short-term intervention for managing TMD, especially in the initial stages of treatment. However, further RCTs with long-term follow-up are warranted.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 227-235"},"PeriodicalIF":6.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regulated cell death (RCD) and survival pathways have emerged as critical factors in periodontal tissue breakdown. However, their precise roles and interactions remain poorly understood. This systematic review aimed to synthesize current evidence regarding the involvement of RCD and survival mechanisms in the progression of periodontitis. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science and Scopus, complemented by manual searching in Google Scholar, following PRISMA guidelines. After removing duplicates, 549 studies underwent title and abstract screening. Of these, 56 articles were selected for full-text review and 18 studies met the eligibility criteria and were included in the final synthesis. Ferroptosis, pyroptosis and necroptosis were consistently associated with inflammatory exacerbation, alveolar bone loss and disease progression. In contrast, autophagy and apoptosis exhibited dual roles—protective or destructive—depending on cell types, disease stage and experimental conditions. Most studies utilized ligature-induced periodontitis animal models. Several studies also demonstrated the therapeutic potential of modulating specific RCD pathways to control inflammation and promote periodontal tissue regeneration, highlighting possible translational strategies for host-modulation therapy of periodontitis. This systematic review consolidates the pivotal role of RCD in the progression of periodontitis. Targeting RCD pathways may represent novel therapeutic strategies to reduce periodontal inflammation and tissue destruction.
调节细胞死亡（RCD）和存活途径已成为牙周组织破坏的关键因素。然而，它们的确切作用和相互作用仍然知之甚少。本系统综述旨在综合目前关于RCD在牙周炎进展中的参与和生存机制的证据。在PubMed/MEDLINE、Web of Science和Scopus中进行了系统的文献检索，并在谷歌Scholar中进行了人工检索，遵循PRISMA指南。在去除重复项后，549项研究进行了标题和摘要筛选。其中，56篇文章被选择进行全文审查，18篇研究符合资格标准，并被纳入最终的综合。铁下垂、焦下垂和坏死性下垂始终与炎症加重、牙槽骨丢失和疾病进展相关。相反，自噬和凋亡表现出保护或破坏的双重作用，这取决于细胞类型、疾病阶段和实验条件。大多数研究使用结扎性牙周炎动物模型。几项研究也证明了调节特定RCD通路控制炎症和促进牙周组织再生的治疗潜力，强调了宿主调节治疗牙周炎的可能的翻译策略。本系统综述巩固了RCD在牙周炎进展中的关键作用。靶向RCD通路可能是减少牙周炎症和组织破坏的新治疗策略。
{"title":"Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review","authors":"Alfredo Torres , Leonardo Díaz , Jaime Oyarzún , M. Angélica Michea , Xiaowei Xu , Flavio Salazar-Onfray , Fermín E. González","doi":"10.1016/j.jdsr.2025.08.001","DOIUrl":"10.1016/j.jdsr.2025.08.001","url":null,"abstract":"<div><div>Regulated cell death (RCD) and survival pathways have emerged as critical factors in periodontal tissue breakdown. However, their precise roles and interactions remain poorly understood. This systematic review aimed to synthesize current evidence regarding the involvement of RCD and survival mechanisms in the progression of periodontitis. A systematic literature search was conducted in PubMed/MEDLINE, Web of Science and Scopus, complemented by manual searching in Google Scholar, following PRISMA guidelines. After removing duplicates, 549 studies underwent title and abstract screening. Of these, 56 articles were selected for full-text review and 18 studies met the eligibility criteria and were included in the final synthesis. Ferroptosis, pyroptosis and necroptosis were consistently associated with inflammatory exacerbation, alveolar bone loss and disease progression. In contrast, autophagy and apoptosis exhibited dual roles—protective or destructive—depending on cell types, disease stage and experimental conditions. Most studies utilized ligature-induced periodontitis animal models. Several studies also demonstrated the therapeutic potential of modulating specific RCD pathways to control inflammation and promote periodontal tissue regeneration, highlighting possible translational strategies for host-modulation therapy of periodontitis. This systematic review consolidates the pivotal role of RCD in the progression of periodontitis. Targeting RCD pathways may represent novel therapeutic strategies to reduce periodontal inflammation and tissue destruction.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 213-226"},"PeriodicalIF":6.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-15DOI: 10.1016/j.jdsr.2025.07.002
Larissa Yumi Ito, Letícia Simeoni Avais, Elis Carolina Pacheco, Leticia Maira Wambier, Alexandra Mara de Paula, Taíse Alessandra Hanzen, Alessandra Reis, Denise Stadler Wambier, Ana Cláudia Rodrigues Chibinski
This systematic review analyzed effectiveness of resin sealants in arresting caries lesions in the outer 1/3 of dentin compared to restorations in deciduous/permanent teeth. Seven databases were searched for randomized clinical trials (December/2024), considering the outcomes “caries progression”, “material retention”, “tertiary dentin formation”, with a minimum 6 months follow-up. Risk of bias was assessed with RoB 2; meta-analysis used risk difference as effect measure in random effects model and Cochran Q test / I2 statistics for heterogeneity; GRADE assessed the evidence certainty. From 6251, 6 papers addressing deciduous (3 high; 3 low risk of bias) and 3 permanent teeth (1 high; 2 low) were included. In deciduous teeth, difference wasn’t observed for “caries progression” [0.02 (-0.04–0.08; p = 0.54); I2= 0 % (p = 0.79)] or “material retention” [0.09 (-0.01–0.19); I2= 35 % (p = 0.18)]. In permanent teeth, there was no difference for “caries progression” [-0.01 (-0.08–0.06); I2 = 30 % (p = 0.23)] and “tertiary dentin” [0.04 (-0.00–0.09); I2 = 0 % (p = 0.51)]; “material retention” favored restorations after 48 months [0.08 (0.04–0.12); I2 = 0 % (p = 0.34)]. In conclusion, sealants can be used to treat initial dentin caries lesions in deciduous and permanent teeth; however, the certainty of the evidence is low and moderate, respectively, and the findings must be taken carefully.
{"title":"Are resin sealants effective to treat caries lesions in the outer 1/3 of dentin compared to composite resin restorations? Systematic review and meta-analysis","authors":"Larissa Yumi Ito, Letícia Simeoni Avais, Elis Carolina Pacheco, Leticia Maira Wambier, Alexandra Mara de Paula, Taíse Alessandra Hanzen, Alessandra Reis, Denise Stadler Wambier, Ana Cláudia Rodrigues Chibinski","doi":"10.1016/j.jdsr.2025.07.002","DOIUrl":"10.1016/j.jdsr.2025.07.002","url":null,"abstract":"<div><div>This systematic review analyzed effectiveness of resin sealants in arresting caries lesions in the outer 1/3 of dentin compared to restorations in deciduous/permanent teeth. Seven databases were searched for randomized clinical trials (December/2024), considering the outcomes “caries progression”, “material retention”, “tertiary dentin formation”, with a minimum 6 months follow-up. Risk of bias was assessed with RoB 2; meta-analysis used risk difference as effect measure in random effects model and Cochran Q test / I<sup>2</sup> statistics for heterogeneity; GRADE assessed the evidence certainty. From 6251, 6 papers addressing deciduous (3 high; 3 low risk of bias) and 3 permanent teeth (1 high; 2 low) were included. In deciduous teeth, difference wasn’t observed for “caries progression” [0.02 (-0.04–0.08; p = 0.54); I<sup>2</sup>= 0 % (p = 0.79)] or “material retention” [0.09 (-0.01–0.19); I<sup>2</sup>= 35 % (p = 0.18)]. In permanent teeth, there was no difference for “caries progression” [-0.01 (-0.08–0.06); I<sup>2</sup> = 30 % (p = 0.23)] and “tertiary dentin” [0.04 (-0.00–0.09); I<sup>2</sup> = 0 % (p = 0.51)]; “material retention” favored restorations after 48 months [0.08 (0.04–0.12); I<sup>2</sup> = 0 % (p = 0.34)]. In conclusion, sealants can be used to treat initial dentin caries lesions in deciduous and permanent teeth; however, the certainty of the evidence is low and moderate, respectively, and the findings must be taken carefully.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 200-212"},"PeriodicalIF":6.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-12DOI: 10.1016/j.jdsr.2025.08.002
Ke Dou , Yue Shi , Baoyi Yang , Zhiguo Zhao
Objective
The aim of the present study was to assess and compare the bleeding risks in patients undergoing dentoalveolar surgery who were on uninterrupted therapy with direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs).
Methods
Electronic database searches were performed in PubMed, Embase, Web of Science, and CENTRAL through 28 September 2024, following PICOS criteria. Two reviewers independently performed literature screening, data extraction, and assessed the risk of bias. Data were pooled to estimate risk ratios (RR) with 95 % confidence intervals (CI) using a fixed-effects model. Between-study heterogeneity was assessed with the Q statistic and I2. Subgroup analyses were conducted according to study characteristics, while sensitivity analyses were used to pinpoint potential sources of heterogeneity and evaluate the reliability of the results.
Results
29 studies enrolled a total of 29,212 patients. Meta-analysis demonstrated a reduced risk of bleeding in patients receiving DOACs compared to those treated with VKAs (RR = 0.79, 95 % CI: 0.68–0.92, I2 = 0 %, P = 0.002). Subgroup analysis revealed a significantly reduced risk of bleeding with dabigatran compared to VKAs (RR = 0.40, 95 % CI: 0.23–0.67, I2 = 0 %, P = 0.0006). However, no statistically significant differences were found between rivaroxaban (RR = 1.08, 95 % CI: 0.84–1.39, I² = 38 %, P = 0.54), apixaban (RR = 0.88, 95 % CI: 0.64–1.3, I² = 0 %, P = 0.46), edoxaban (RR = 0.70, 95 % CI: 0.45–1.11, I² = 60 %, P = 0.13) and VKAs. Combined analyses indicated an increased risk of bleeding with DOACs compared to controls (RR = 3.23, 95 % CI: 2.18–4.78, I2 = 24 %, P < 0.0001), as well as increased bleeding risk with VKAs (RR = 3.35, 95 % CI: 2.31–4.85, I2 = 0 %, P ＜ 0.0001).
Conclusions
Patients receiving DOACs or VKAs have an increased risk of bleeding during dentoalveolar surgery, but severe bleeding requiring hospitalization or causing irreversible damage is rare. Patients using DOACs appear to have a lower bleeding risk compared to those on VKAs. This difference is mainly observed in dabigatran etexilate, while it remains unclear in rivaroxaban, apixaban, and edoxaban. Current quality of evidence is very low, which should be interpreted with caution. Future studies with higher quality of evidence are required to strengthen the validity of these findings.
{"title":"Risk of bleeding with dentoalveolar surgery in patients taking direct oral anticoagulants or vitamin K antagonists: A systematic review and meta-analysis","authors":"Ke Dou , Yue Shi , Baoyi Yang , Zhiguo Zhao","doi":"10.1016/j.jdsr.2025.08.002","DOIUrl":"10.1016/j.jdsr.2025.08.002","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the present study was to assess and compare the bleeding risks in patients undergoing dentoalveolar surgery who were on uninterrupted therapy with direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs).</div></div><div><h3>Methods</h3><div>Electronic database searches were performed in PubMed, Embase, Web of Science, and CENTRAL through 28 September 2024, following PICOS criteria. Two reviewers independently performed literature screening, data extraction, and assessed the risk of bias. Data were pooled to estimate risk ratios (RR) with 95 % confidence intervals (CI) using a fixed-effects model. Between-study heterogeneity was assessed with the Q statistic and I<sup>2</sup>. Subgroup analyses were conducted according to study characteristics, while sensitivity analyses were used to pinpoint potential sources of heterogeneity and evaluate the reliability of the results.</div></div><div><h3>Results</h3><div>29 studies enrolled a total of 29,212 patients. Meta-analysis demonstrated a reduced risk of bleeding in patients receiving DOACs compared to those treated with VKAs (RR = 0.79, 95 % CI: 0.68–0.92, I<sup>2</sup> = 0 %, P = 0.002). Subgroup analysis revealed a significantly reduced risk of bleeding with dabigatran compared to VKAs (RR = 0.40, 95 % CI: 0.23–0.67, I<sup>2</sup> = 0 %, P = 0.0006). However, no statistically significant differences were found between rivaroxaban (RR = 1.08, 95 % CI: 0.84–1.39, I² = 38 %, P = 0.54), apixaban (RR = 0.88, 95 % CI: 0.64–1.3, I² = 0 %, P = 0.46), edoxaban (RR = 0.70, 95 % CI: 0.45–1.11, I² = 60 %, P = 0.13) and VKAs. Combined analyses indicated an increased risk of bleeding with DOACs compared to controls (RR = 3.23, 95 % CI: 2.18–4.78, I<sup>2</sup> = 24 %, P < 0.0001), as well as increased bleeding risk with VKAs (RR = 3.35, 95 % CI: 2.31–4.85, I<sup>2</sup> = 0 %, P ＜ 0.0001).</div></div><div><h3>Conclusions</h3><div>Patients receiving DOACs or VKAs have an increased risk of bleeding during dentoalveolar surgery, but severe bleeding requiring hospitalization or causing irreversible damage is rare. Patients using DOACs appear to have a lower bleeding risk compared to those on VKAs. This difference is mainly observed in dabigatran etexilate, while it remains unclear in rivaroxaban, apixaban, and edoxaban. Current quality of evidence is very low, which should be interpreted with caution. Future studies with higher quality of evidence are required to strengthen the validity of these findings.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 188-199"},"PeriodicalIF":6.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-14DOI: 10.1016/j.jdsr.2025.07.001
Shih-Ying Lin , Hung-Ying Lin , Jui-Sheng Sun , Jenny Zwei-Chieng Chang
This study evaluates the effectiveness of adjunctive therapies combined with non-surgical periodontal treatment for Stage III/IV Grade C periodontitis, focusing on pocket depth (PD) reduction, clinical attachment level (CAL) gain, and adverse events. A systematic review and network meta-analysis were conducted, including randomized controlled trials up to September 2024. Inconsistencies and publication bias were detected, prompting sensitivity analyses and effectiveness rankings of adjunctive therapies. Data from 50 studies were included, with 45 entered into network meta-analysis, covering 24 interventions and 1431 patients. Compared to scaling and root planing (SRP) alone, adjunctive systemic lincosamides with nitroimidazole (Mac/Linc+Nitro-S) demonstrated the greatest PD reduction, followed by local statins (Statins-L) in the short term (≤3 months). Statins-L also provided the highest CAL gain. In the medium term (4–6 months), Statins-L remained the most effective, followed by bisphosphonates. For long-term (>6 months) follow-up, where fewer treatment approaches were available, Nitro-S achieved the most significant PD reduction and CAL gain, followed by Mac/Linc-S. Adverse effects were mild and self-limiting. Despite promising findings, inconsistencies in CAL outcomes and potential publication bias highlight the need for further research to confirm long-term safety and efficacy.
{"title":"Efficacy of adjunctive periodontal interventions in non-surgical periodontal therapy for Stage III/IV Grade C periodontitis: A systematic review and network meta-analysis","authors":"Shih-Ying Lin , Hung-Ying Lin , Jui-Sheng Sun , Jenny Zwei-Chieng Chang","doi":"10.1016/j.jdsr.2025.07.001","DOIUrl":"10.1016/j.jdsr.2025.07.001","url":null,"abstract":"<div><div>This study evaluates the effectiveness of adjunctive therapies combined with non-surgical periodontal treatment for Stage III/IV Grade C periodontitis, focusing on pocket depth (PD) reduction, clinical attachment level (CAL) gain, and adverse events. A systematic review and network meta-analysis were conducted, including randomized controlled trials up to September 2024. Inconsistencies and publication bias were detected, prompting sensitivity analyses and effectiveness rankings of adjunctive therapies. Data from 50 studies were included, with 45 entered into network meta-analysis, covering 24 interventions and 1431 patients. Compared to scaling and root planing (SRP) alone, adjunctive systemic lincosamides with nitroimidazole (Mac/Linc+Nitro-S) demonstrated the greatest PD reduction, followed by local statins (Statins-L) in the short term (≤3 months). Statins-L also provided the highest CAL gain. In the medium term (4–6 months), Statins-L remained the most effective, followed by bisphosphonates. For long-term (>6 months) follow-up, where fewer treatment approaches were available, Nitro-S achieved the most significant PD reduction and CAL gain, followed by Mac/Linc-S. Adverse effects were mild and self-limiting. Despite promising findings, inconsistencies in CAL outcomes and potential publication bias highlight the need for further research to confirm long-term safety and efficacy.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 167-187"},"PeriodicalIF":5.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for articles concerning MOMR in Japan. The incidence and characteristics of MOMR were investigated, and the survival time was analyzed. This systematic review identified 211 studies, including 356 cases. There was a male predominance (n = 250/70.2 %) and the mean age at the diagnosis was 62.1 (range, 4–91) years old. The most common primary site was the lungs (n = 104/29.2 %). Oral metastasis sites were equally frequent in the jawbone (n = 182/51.1 %) and soft tissue (n = 174/48.9 %). Among these, the mandible and gingiva were the most common. The most common clinical presentation was a nodule (n = 317/90.3 %). The presence of metastases to other organs (P = 0.009) and uncontrolled primary lesions (P < 0.001) was associated with a shortened survival. This systematic review provides important insights into the clinical features, diagnosis, and treatment of MOMR in Japan and will assist clinicians in their appropriate management.
{"title":"A systematic review of metastatic lesions to the oral and maxillofacial regions among Japanese people","authors":"Seiji Asoda , Takazumi Yasui , Kenta Tanaka , Katsuhiro Onizawa , Hiromasa Kawana , Taneaki Nakagawa","doi":"10.1016/j.jdsr.2025.06.001","DOIUrl":"10.1016/j.jdsr.2025.06.001","url":null,"abstract":"<div><div>This review aimed to integrate the available data published in the literature on metastatic lesions in the oral and maxillofacial region (MOMR) and to produce an updated comprehensive analysis of its clinical characteristics, treatment, and prognosis. An electronic database search was conducted for articles concerning MOMR in Japan. The incidence and characteristics of MOMR were investigated, and the survival time was analyzed. This systematic review identified 211 studies, including 356 cases. There was a male predominance (n = 250/70.2 %) and the mean age at the diagnosis was 62.1 (range, 4–91) years old. The most common primary site was the lungs (n = 104/29.2 %). Oral metastasis sites were equally frequent in the jawbone (n = 182/51.1 %) and soft tissue (n = 174/48.9 %). Among these, the mandible and gingiva were the most common. The most common clinical presentation was a nodule (n = 317/90.3 %). The presence of metastases to other organs (P = 0.009) and uncontrolled primary lesions (P < 0.001) was associated with a shortened survival. This systematic review provides important insights into the clinical features, diagnosis, and treatment of MOMR in Japan and will assist clinicians in their appropriate management.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 155-166"},"PeriodicalIF":5.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-10DOI: 10.1016/j.jdsr.2025.05.001
Noelia Seijas-Otero, Triana Blanco-Pintos , Alba Regueira-Iglesias, Berta Suárez-Rodríguez, Alba Sánchez-Barco, Carlos Balsa-Castro, Inmaculada Tomás
This study represents the first Bayesian network meta-analysis (NMA), which aimed to determine the virucidal efficacy of oral and nasal antiseptics against SARS-CoV-2 in saliva. Eligible studies evaluated the antiseptics’ effect on viral load in SARS-CoV-2-infected subjects. The search was performed in September 2024 through PubMed, World Health Organisation, Embase, Scopus, bioRxiv, and medRxiv. The methodological quality was evaluated using the Cochrane RoB-2 checklist. Twenty-six articles and 16 antiseptics were assessed. Bayesian NMA was possible for seven antiseptics, ranked by probability of best option for viral load reduction (SUCRA values): PVP-I (0.85); CPC and CHX (0.72); H2O2 (0.70); CHX (0.64); CPC (0.50); H2O2 and CHX (0.38); and HClO (0.34). Virucidal efficacy at baseline was significant for (viral load reduction): PVP-I (42 %), H2O2 (34 %), and CHX (31 %). Compared to the control group, PVP-I remained significant (34 %), whereas H2O2 and CHX approached significance (26 % and 22 %, respectively). In conclusion, a single application of PVP-I, H2O2 or CHX are the best options for reducing the SARS-CoV-2 viral load in saliva, which can be particularly relevant in high-risk settings. However, methodologically well-designed studies using more appropriate quantification techniques are needed to clarify better the clinical efficacy of antiseptics against SARS-CoV-2 and other respiratory viruses.
{"title":"Antiseptics as effective virucidal agents against SARS-CoV-2: Systematic review and Bayesian network meta-analysis","authors":"Noelia Seijas-Otero, Triana Blanco-Pintos , Alba Regueira-Iglesias, Berta Suárez-Rodríguez, Alba Sánchez-Barco, Carlos Balsa-Castro, Inmaculada Tomás","doi":"10.1016/j.jdsr.2025.05.001","DOIUrl":"10.1016/j.jdsr.2025.05.001","url":null,"abstract":"<div><div>This study represents the first Bayesian network meta-analysis (NMA), which aimed to determine the virucidal efficacy of oral and nasal antiseptics against SARS-CoV-2 in saliva. Eligible studies evaluated the antiseptics’ effect on viral load in SARS-CoV-2-infected subjects. The search was performed in September 2024 through PubMed, World Health Organisation, Embase, Scopus, bioRxiv, and medRxiv. The methodological quality was evaluated using the Cochrane RoB-2 checklist. Twenty-six articles and 16 antiseptics were assessed. Bayesian NMA was possible for seven antiseptics, ranked by probability of best option for viral load reduction (SUCRA values): PVP-I (0.85); CPC and CHX (0.72); H<sub>2</sub>O<sub>2</sub> (0.70); CHX (0.64); CPC (0.50); H<sub>2</sub>O<sub>2</sub> and CHX (0.38); and HClO (0.34). Virucidal efficacy at baseline was significant for (viral load reduction): PVP-I (42 %), H<sub>2</sub>O<sub>2</sub> (34 %), and CHX (31 %). Compared to the control group, PVP-I remained significant (34 %), whereas H<sub>2</sub>O<sub>2</sub> and CHX approached significance (26 % and 22 %, respectively). In conclusion, a single application of PVP-I, H<sub>2</sub>O<sub>2</sub> or CHX are the best options for reducing the SARS-CoV-2 viral load in saliva, which can be particularly relevant in high-risk settings. However, methodologically well-designed studies using more appropriate quantification techniques are needed to clarify better the clinical efficacy of antiseptics against SARS-CoV-2 and other respiratory viruses.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 138-154"},"PeriodicalIF":5.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-04DOI: 10.1016/j.jdsr.2025.05.003
Reinaldo Adelino de Sales-Junior , Mariana Silva de Bessa , Francisca Jennifer Duarte de Oliveira , Bárbara Faria de Sá Barbosa , Kaiza de Sousa Santos , Michael Owen , Victor Pinheiro Feitosa , Boniek Castillo Dutra Borges
This scoping review aimed to collect, analyze, synthesize, and interpret the current data concerning antibacterial resin-based composites. The study followed the recommendations of the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. The searches were conducted in the PubMed, Embase, Web of Science, and Scopus databases. Studies evaluating efficacy, physical and chemical properties, cytotoxicity, and preventive effect against recurrent caries lesions provided by antibacterial resin-based composites published in the last 5 years and without language restriction were included. Fifty-three papers were analyzed. Only in vitro, in situ, and animal studies were published. The DMAHDM (dimethylaminohexadecyl methacrylate) was the most prevalent antibacterial agent in the resin composites and showed efficacy, did not increase cytotoxicity, nor jeopardize chemical and physical properties. The most used biofilm model and the test to evaluate the antibacterial effect was Streptococcus Mutans and the Colony Forming Unit Count. Antibacterial resin-based composites have performed exceedingly well in the large number of in vitro studies evaluated. However, clinical trials assessing the prevention of recurrent caries are absent and need to be further conducted to assure that using an antibacterial resin composite is a valid way to avoid restoration replacement due to recurrent caries.
本综述旨在收集、分析、合成和解释目前有关抗菌树脂基复合材料的数据。这项研究遵循了乔安娜布里格斯研究所和PRISMA扩展范围审查的建议。检索在PubMed、Embase、Web of Science和Scopus数据库中进行。本文纳入了近5年来发表的无语言限制的抗菌树脂基复合材料的疗效、理化性质、细胞毒性和预防龋齿复发作用的研究。分析了53篇论文。仅在体外、原位和动物研究中发表。DMAHDM（二甲氨基十六烷基甲基丙烯酸酯）是树脂复合材料中最常用的抗菌剂，具有良好的抗菌效果，不会增加细胞毒性，也不会损害化学和物理性能。最常用的生物膜模型和评价抗菌效果的试验是变形链球菌和菌落形成单位计数。抗菌树脂基复合材料在大量体外研究中表现非常好。然而，临床试验评估预防复发性龋齿缺乏，需要进一步进行，以确保使用抗菌树脂复合材料是一种有效的方法，以避免因复发性龋齿而更换修复体。
{"title":"Multifaceted characterization of antibacterial resin composites: A scoping review on efficacy, properties, and in vivo performance","authors":"Reinaldo Adelino de Sales-Junior , Mariana Silva de Bessa , Francisca Jennifer Duarte de Oliveira , Bárbara Faria de Sá Barbosa , Kaiza de Sousa Santos , Michael Owen , Victor Pinheiro Feitosa , Boniek Castillo Dutra Borges","doi":"10.1016/j.jdsr.2025.05.003","DOIUrl":"10.1016/j.jdsr.2025.05.003","url":null,"abstract":"<div><div>This scoping review aimed to collect, analyze, synthesize, and interpret the current data concerning antibacterial resin-based composites. The study followed the recommendations of the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. The searches were conducted in the PubMed, Embase, Web of Science, and Scopus databases. Studies evaluating efficacy, physical and chemical properties, cytotoxicity, and preventive effect against recurrent caries lesions provided by antibacterial resin-based composites published in the last 5 years and without language restriction were included. Fifty-three papers were analyzed. Only <em>in vitro, in situ</em>, and animal studies were published. The DMAHDM (dimethylaminohexadecyl methacrylate) was the most prevalent antibacterial agent in the resin composites and showed efficacy, did not increase cytotoxicity, nor jeopardize chemical and physical properties. The most used biofilm model and the test to evaluate the antibacterial effect was Streptococcus Mutans and the Colony Forming Unit Count. Antibacterial resin-based composites have performed exceedingly well in the large number of <em>in vitro</em> studies evaluated. However, clinical trials assessing the prevention of recurrent caries are absent and need to be further conducted to assure that using an antibacterial resin composite is a valid way to avoid restoration replacement due to recurrent caries.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 112-137"},"PeriodicalIF":5.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-31DOI: 10.1016/j.jdsr.2025.05.002
Kunhua Yang , Alexander Patera Nugraha , Junduo Chen , Hui Yang , Jingyu Wang , Juan Ramón Vanegas Sáenz , Guang Hong
This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was conducted using MEDLINE/PubMed, Scopus, Web of Science, Scopus, and Embase for English-language publications with no date restrictions, yielding 180 publications. After removing duplicates, 150 remained, from which 23 were evaluated in full. 17 in vitro studies met the inclusion criteria, of which 13 had a low risk of bias, 4 had a moderate risk, and none had a high risk. Across all included investigations, CNF consistently improved mechanical performance, particularly flexural and compressive strength, while maintaining or enhancing biocompatibility in various cell culture models. CNF’s nanofibrillar structure and modifiable surface chemistry also expanded its functional versatility, enabling applications such as drug encapsulation and targeted antimicrobial delivery. Overall, CNF emerges as a promising biomaterial for modern dentistry, offering superior mechanical reinforcement, favorable cell responses, and wide-ranging functional modifications. Further in vivo research and clinical trials are necessary to confirm its long-term safety and efficacy, thereby facilitating the translation of these in vitro findings into standard dental practice.
本系统综述旨在确定纤维素纳米纤维（CNF）如何增强牙科材料的机械性能、生物相容性和功能通用性，基于体外证据。根据PRISMA 2020制定了系统审查方案。文献检索使用MEDLINE/PubMed、Scopus、Web of Science、Scopus和Embase对无日期限制的英文出版物进行检索，共检索到180篇出版物。去除重复项后，剩下150项，其中23项被完全评估。17项体外研究符合纳入标准，其中13项为低偏倚风险，4项为中等偏倚风险，无高风险。在所有包括的研究中，CNF持续改善机械性能，特别是弯曲和抗压强度，同时保持或增强各种细胞培养模型的生物相容性。CNF的纳米纤维结构和可修饰的表面化学也扩展了其功能的多功能性，使其能够应用于药物封装和靶向抗菌药物输送等领域。总的来说，CNF作为一种有前途的现代牙科生物材料，提供优越的机械加固，有利的细胞反应和广泛的功能修饰。进一步的体内研究和临床试验是必要的，以确认其长期安全性和有效性，从而促进这些体外研究结果转化为标准的牙科实践。
{"title":"Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence","authors":"Kunhua Yang , Alexander Patera Nugraha , Junduo Chen , Hui Yang , Jingyu Wang , Juan Ramón Vanegas Sáenz , Guang Hong","doi":"10.1016/j.jdsr.2025.05.002","DOIUrl":"10.1016/j.jdsr.2025.05.002","url":null,"abstract":"<div><div>This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was conducted using MEDLINE/PubMed, Scopus, Web of Science, Scopus, and Embase for English-language publications with no date restrictions, yielding 180 publications. After removing duplicates, 150 remained, from which 23 were evaluated in full. 17 in vitro studies met the inclusion criteria, of which 13 had a low risk of bias, 4 had a moderate risk, and none had a high risk. Across all included investigations, CNF consistently improved mechanical performance, particularly flexural and compressive strength, while maintaining or enhancing biocompatibility in various cell culture models. CNF’s nanofibrillar structure and modifiable surface chemistry also expanded its functional versatility, enabling applications such as drug encapsulation and targeted antimicrobial delivery. Overall, CNF emerges as a promising biomaterial for modern dentistry, offering superior mechanical reinforcement, favorable cell responses, and wide-ranging functional modifications. Further in vivo research and clinical trials are necessary to confirm its long-term safety and efficacy, thereby facilitating the translation of these in vitro findings into standard dental practice.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 103-111"},"PeriodicalIF":5.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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