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Clinical use of duplicate complete dentures: A narrative review 复制全口义齿的临床使用:叙述性综述
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-14 DOI: 10.1016/j.jdsr.2024.05.005
Nobuhiro Yoda , Masumi Abe , Hirofumi Yamaguchi , Naomi Tanoue , Tetsuo Yamamori

Most reports on duplicate dentures are introduction to fabrication methods or clinical case reports. Only a few studies have verified their clinical effectiveness; hence, evidence to construct useful clinical guidelines for duplicate denture use is lacking. This review aimed to comprehensively investigate reports on duplicate dentures to accumulate evidences that will contribute to the formulation of clinical practice guidelines. Duplicate dentures are effectively used for impression making and bite registration when fabricating new dentures, thereby reducing the number of clinic visits and treatment time. Duplicate denture can also be used as temporary or new dentures. Older people in whom various adaptive abilities have declined, may find it difficult to adjust to new dentures and experience stress, even if the shape is appropriate. Duplicate dentures, which reproduces the shape of old dentures that they are used to, have the advantage of being more familiar to older people and less stressful. When manufacturing duplicate dentures, digital methods such as milling and three-dimensional printing are superior to conventional methods regarding working time and cost. A notable advantage of the digital method is that the denture shape can be saved as digital data, and the denture can be easily duplicated if lost.

大多数关于重复义齿的报道都是介绍制作方法或临床病例报告。只有少数研究验证了它们的临床有效性;因此,缺乏证据来为重复义齿的使用制定有用的临床指南。本综述旨在全面调查有关复式义齿的报告,以积累有助于制定临床实践指南的证据。制作新义齿时,复制义齿可有效用于印模和咬合登记,从而减少就诊次数和治疗时间。复制义齿还可用作临时义齿或新义齿。各种适应能力下降的老年人可能难以适应新假牙,即使假牙形状合适,也会感到紧张。复制假牙可以再现老年人习惯的旧假牙形状,其优点是老年人更熟悉,压力更小。在制作复型假牙时,铣削和三维打印等数字化方法在工作时间和成本方面都优于传统方法。数字化方法的一个显著优势是可以将假牙形状保存为数字化数据,如果丢失,可以很容易地复制假牙。
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引用次数: 0
Different surface treatments and adhesive monomers for zirconia-resin bonds: A systematic review and network meta-analysis 氧化锆-树脂粘接的不同表面处理和粘接单体:系统综述和网络荟萃分析
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-07 DOI: 10.1016/j.jdsr.2024.05.004
Xinyang Li , Shengjie Liang , Masanao Inokoshi , Shikai Zhao , Guang Hong , Chenmin Yao , Cui Huang

This review examined the efficacy of surface treatments and adhesive monomers for enhancing zirconia-resin bond strength. A comprehensive literature search in PubMed, Embase, Web of Science, Scopus, and the Cochrane Library yielded relevant in vitro studies. Employing pairwise and Bayesian network meta-analyses, 77 articles meeting inclusion criteria were analyzed. Gas plasma was found to be ineffective, while treatments including air abrasion, silica coating, laser, selective infiltration etching, hot etching showed varied effectiveness. Air abrasion with finer particles (25–53 µm) showed higher immediate bond strength than larger particles (110–150 µm), with no significant difference post-aging. The Rocatec silica coating system outperformed the CoJet system in both immediate and long-term bond strength. Adhesives containing 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) were superior to other acidic monomers. The application of 2-hydroxyethyl methacrylate and silane did not improve bonding performance. Notably, 91.2 % of bonds weakened after aging, but this effect was less pronounced with air abrasion or silica coating. The findings highlight the effectiveness of air abrasion, silica coating, selective infiltration etching, hot etching, and laser treatment in improving bond strength, with 10-MDP in bonding agents enhancing zirconia bonding efficacy.

本综述研究了表面处理和粘合剂单体在增强氧化锆-树脂粘接强度方面的功效。通过对 PubMed、Embase、Web of Science、Scopus 和 Cochrane 图书馆进行全面的文献检索,得出了相关的体外研究结果。通过配对分析和贝叶斯网络荟萃分析,对符合纳入标准的 77 篇文章进行了分析。结果发现,气体等离子体的效果不佳,而包括气磨、二氧化硅涂层、激光、选择性浸润蚀刻和热蚀刻在内的处理方法则显示出不同的效果。与较大的颗粒(110-150 微米)相比,使用较细颗粒(25-53 微米)的气磨显示出更高的即时粘接强度,但老化后没有显著差异。Rocatec 二氧化硅涂层系统的即时和长期粘接强度均优于 CoJet 系统。含有 10-甲基丙烯酰氧癸基磷酸二氢酯(10-MDP)的粘合剂优于其他酸性单体。使用甲基丙烯酸 2-羟乙基酯和硅烷并不能提高粘接性能。值得注意的是,91.2% 的粘接剂在老化后会变弱,但这种影响在空气磨蚀或硅涂层中并不明显。研究结果凸显了空气研磨、二氧化硅涂层、选择性渗透蚀刻、热蚀刻和激光处理在提高粘接强度方面的有效性,粘接剂中的 10-MDP 可提高氧化锆的粘接效果。
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引用次数: 0
The clinical efficacy of powder air-polishing in the non-surgical treatment of peri-implant diseases: A systematic review and meta-analysis 气垫粉末在非手术治疗种植体周围疾病中的临床疗效:系统回顾与荟萃分析
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-22 DOI: 10.1016/j.jdsr.2024.05.003
Nengwen Huang , Yang Li , Huachen Chen , Wen Li , Chengchaozi Wang , YanJing OU , Masahiro Likubo , Jiang Chen

Peri-implant diseases, characterized by inflammatory conditions affecting peri-implant tissues, encompass peri-implant mucositis and peri-implantitis. Peri-implant mucositis is an inflammatory lesion limited to the mucosa around an implant, while peri-implantitis extends from the mucosa to the supporting bone, causing a loss of osseointegration. For non-surgical treatments, we tested the null hypothesis that the presence or absence of air-polishing made no difference. The study focused on randomized controlled trials (RCTs) comparing air-polishing with mechanical or ultrasonic debridement, evaluating outcomes such as bleeding on probing (BOP), probing depth (PD), plaque index/plaque score (PI/PS), clinical attachment level (CAL), bone loss, and mucosal recession (MR). Two independent reviewers conducted data extraction and quality assessments, considering short-term (<6 months) and long-term (≥6 months) follow-up periods. After screening, ten articles were included in the meta-analysis. In nonsurgical peri-implant disease management, air-polishing moderately mitigated short-term PI/PS for peri-implant mucositis and showed a similar improvement in long-term BOP and bone loss for peri-implantitis compared to the control group. The Egger test found no evidence of publication bias except for the long-term PI/PS of peri-implant mucositis. Leave-one-out analysis confirmed the stability of the results. The findings highlight the need for future research with longer-term follow-up and high-quality, multi-center, large-sample RCTs.

种植体周围疾病的特征是影响种植体周围组织的炎症,包括种植体周围粘膜炎和种植体周围炎。种植体周围粘膜炎是局限于种植体周围粘膜的炎性病变,而种植体周围炎则从粘膜延伸到支撑骨,导致骨结合丧失。对于非手术治疗方法,我们检验了有无空气抛光没有区别的零假设。研究重点是比较空气抛光与机械或超声波清创的随机对照试验(RCT),评估的结果包括探诊出血(BOP)、探诊深度(PD)、牙菌斑指数/牙菌斑评分(PI/PS)、临床附着水平(CAL)、骨质流失和粘膜萎缩(MR)。两位独立审稿人在考虑短期(6 个月)和长期(≥6 个月)随访期的情况下进行了数据提取和质量评估。经过筛选,十篇文章被纳入荟萃分析。在非手术治疗种植体周围疾病方面,与对照组相比,空气抛光可适度减轻种植体周围粘膜炎的短期PI/PS,并对种植体周围炎的长期BOP和骨质流失有类似的改善作用。除了种植体周围粘膜炎的长期 PI/PS 外,Egger 检验没有发现发表偏倚的证据。留空分析证实了结果的稳定性。研究结果突出表明,今后的研究需要更长期的随访和高质量、多中心、大样本的 RCT。
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引用次数: 0
Caries preventive potential of professionally deliverable fluoride-containing agents with incorporated arginine: A scoping review 含有精氨酸的专业给药含氟制剂的龋齿预防潜力:范围审查
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-22 DOI: 10.1016/j.jdsr.2024.05.002
Nouf Ali Alblooshi , Tiba Kahtan Naseer , Mohammed Nadeem Bijle

The scoping review objectives were to: 1) investigate the caries preventive potential of professionally deliverable fluoride (F)-containing agents with incorporated arginine (Arg); and 2) identify the future scope of research on Arg-F interventions for caries prevention. Of 150 identified records, 7 articles (6 in vitro investigations and 1 scoping review) were included for a complete review; with no clinical studies with/without appraisal. Arginine variants (L-Arg/Arg.HCl at 1% to 10% w/v.) were examined for a potential professional application aimed at caries prevention, as reported with in vitro studies. Of the included articles, four in vitro studies explored L-Arg enriched 5% NaF varnish (Duraphat®) as a promising caries preventive agent, while only one considered incorporating L-Arg in MI varnish®/nanohydroxyapatite and one investigated glass ionomer cement for primary/secondary and tertiary caries prevention. The scoping review highlighted the scope for incorporating Arg to professionally deliverable F-containing agents. No clinical data are available to make conclusive recommendations about the caries preventive potential of professionally deliverable F-containing agents with incorporated Arg. With Arg-F varnish being investigated predominantly through in vitro studies, the data so far suggest that Arg was incorporated exclusively in Duraphat®, while the potential of Arg to prevent caries in other F-containing varnishes remains unexplored.

范围界定审查的目标是1)研究含有精氨酸(Arg)的专业递送型含氟(F)制剂的龋齿预防潜力;以及 2)确定 Arg-F 预防龋齿干预措施的未来研究范围。在已确定的 150 份记录中,有 7 篇文章(6 篇体外调查和 1 篇范围审查)被纳入完整审查;没有进行临床研究,也没有进行评估。根据体外研究报告,对精氨酸变体(L-Arg/Arg.HCl,1%-10% w/v.)进行了检查,以了解其在预防龋齿方面的潜在专业应用。在收录的文章中,有四项体外研究探讨了将富含 L-Arg 的 5%NaF清漆(Duraphat®)作为一种很有前景的龋病预防剂,只有一项研究考虑了将 L-Arg 加入 MI 清漆®/纳米羟基磷灰石中,还有一项研究调查了用于一级/二级和三级预防龋病的玻璃离聚体水泥。范围界定审查强调了将 Arg 加入可专业递送的含氟制剂的范围。目前还没有临床数据可以对添加了 Arg 的专业含氟牙剂的龋齿预防潜力提出结论性建议。Arg-F清漆主要通过体外研究进行调查,迄今为止的数据表明,Arg仅被纳入Duraphat®中,而Arg在其他含氟清漆中预防龋齿的潜力仍有待探索。
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引用次数: 0
Dental and oral management in the perioperative period of surgery: A scoping review 手术围手术期的牙科和口腔管理:范围综述
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-11 DOI: 10.1016/j.jdsr.2024.03.002
Hironori Sakai , Hiroshi Kurita , Eiji Kondo , Hirokazu Tanaka , Tetsu Shimane , Masao Hashidume , Shin-Ichi Yamada

Dental and oral management (DOM) is a long-established treatment modality. This scoping review aimed to narratively review previous studies, examine the effects of perioperative DOM, and identify the available evidence. A literature search was conducted using the PubMed electronic database for studies published between January 1, 2000, and March 8, 2022. The search yielded 43 studies, most of which were published in the last 10 years. The results of this study confirmed that improved perioperative oral hygiene is effective in preventing postoperative pneumonia. Our results also suggested that preoperative DOM is effective in preventing postoperative surgical site infections. Perioperative DOM is effective in reducing the incidence of postoperative pneumonia, SSI, and postsurgical complications. Further studies are needed to elucidate the various mechanism of DOM and to examine efficient intervention methods and timing.

牙科和口腔管理(DOM)是一种历史悠久的治疗方式。本范围综述旨在对以往的研究进行叙述性综述,研究围手术期口腔护理的效果,并确定可用的证据。我们使用 PubMed 电子数据库对 2000 年 1 月 1 日至 2022 年 3 月 8 日期间发表的研究进行了文献检索。搜索结果显示有 43 项研究,其中大部分发表于最近 10 年。本研究结果证实,改善围手术期口腔卫生可有效预防术后肺炎。我们的研究结果还表明,术前口腔清洁能有效预防术后手术部位感染。围手术期 DOM 能有效降低术后肺炎、SSI 和术后并发症的发生率。还需要进一步的研究来阐明 DOM 的各种机制,并探讨有效的干预方法和时机。
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引用次数: 0
Frequently used extraoral maxillofacial prosthetic materials and their longevity – A comprehensive review 常用口外颌面修复材料及其使用寿命--综合评述
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-05 DOI: 10.1016/j.jdsr.2024.03.001
Lovely M. Annamma , Mariko Hattori , Islam E. Ali , Jovita Dsouza , Anam Waqar , Anshul Chugh , Yuka I. Sumita

The longevity of an extraoral prosthesis depends on its physical and mechanical properties and user maintenance. Faced with multiple outcome measures, researchers find it difficult to determine the most appropriate extraoral prosthetic material. This comprehensive review evaluates the most used extraoral prosthesis materials and qualitatively assesses their longevity and function. The study aims to identify and interpret the results of current updates on the factors that affect longevity and functionality. This comprehensive review summarizes and evaluates differences in the properties of commonly used extraoral maxillofacial prosthetic materials. The review was planned to focus on all factors related to the longevity and function of the extraoral maxillofacial prosthetics. An electronic search covered English articles in PubMed, Scopus, Google Scholar, Web of Science, and grey literature. Manual searching was also performed. Six authors participated in the screening. Search engines extracted 1107 records, and 88 studies were included for qualitative and bias assessments. Silicones are the most frequently used extraoral maxillofacial prosthetic materials. Heat-cured silicones are more color-stable than those cured at room temperature. Additional ingredients and processing techniques affect prosthesis longevity.

口外假体的使用寿命取决于其物理和机械性能以及使用者的维护。面对多种测量结果,研究人员很难确定最合适的口外假体材料。本综述评估了最常用的口外假体材料,并对其寿命和功能进行了定性评估。该研究旨在确定和解释目前关于影响寿命和功能的因素的最新研究结果。这篇全面的综述总结并评估了常用口外颌面修复材料特性的差异。综述计划重点关注与口外颌面修复体的寿命和功能相关的所有因素。电子检索涵盖了PubMed、Scopus、Google Scholar、Web of Science和灰色文献中的英文文章。此外还进行了人工检索。六位作者参与了筛选。搜索引擎提取了 1107 条记录,并纳入了 88 项研究进行定性和偏倚评估。硅树脂是最常用的口外颌面修复材料。热固化有机硅比室温固化的有机硅颜色更稳定。其他成分和加工技术也会影响修复体的寿命。
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引用次数: 0
Diagnostic performance of artificial intelligence-aided caries detection on bitewing radiographs: a systematic review and meta-analysis 人工智能辅助咬翼X光片龋病检测的诊断性能:系统回顾和荟萃分析
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-29 DOI: 10.1016/j.jdsr.2024.02.001
Nour Ammar , Jan Kühnisch

The accuracy of artificial intelligence-aided (AI) caries diagnosis can vary considerably depending on numerous factors. This review aimed to assess the diagnostic accuracy of AI models for caries detection and classification on bitewing radiographs. Publications after 2010 were screened in five databases. A customized risk of bias (RoB) assessment tool was developed and applied to the 14 articles that met the inclusion criteria out of 935 references. Dataset sizes ranged from 112 to 3686 radiographs. While 86 % of the studies reported a model with an accuracy of ≥80 %, most exhibited unclear or high risk of bias. Three studies compared the model’s diagnostic performance to dentists, in which the models consistently showed higher average sensitivity. Five studies were included in a bivariate diagnostic random-effects meta-analysis for overall caries detection. The diagnostic odds ratio was 55.8 (95 % CI= 28.8 – 108.3), and the summary sensitivity and specificity were 0.87 (0.76 – 0.94) and 0.89 (0.75 – 0.960), respectively. Independent meta-analyses for dentin and enamel caries detection were conducted and showed sensitivities of 0.84 (0.80 – 0.87) and 0.71 (0.66 – 0.75), respectively. Despite the promising diagnostic performance of AI models, the lack of high-quality, adequately reported, and externally validated studies highlight current challenges and future research needs.

人工智能辅助(AI)龋齿诊断的准确性会因多种因素而有很大差异。本综述旨在评估人工智能模型在咬合X光片上进行龋齿检测和分类的诊断准确性。在五个数据库中筛选了 2010 年之后发表的文献。我们开发了一个定制的偏倚风险(RoB)评估工具,并将其应用于935篇参考文献中符合纳入标准的14篇文章。数据集的规模从 112 到 3686 张射线照片不等。虽然 86% 的研究报告了准确率≥80% 的模型,但大多数研究显示出不明确或高偏倚风险。有三项研究将模型的诊断性能与牙医进行了比较,其中模型的平均灵敏度一直较高。五项研究被纳入了整体龋齿检测的双变量诊断随机效应荟萃分析。诊断几率比为 55.8 (95 % CI= 28.8 - 108.3),灵敏度和特异度分别为 0.87 (0.76 - 0.94) 和 0.89 (0.75 - 0.960)。对牙本质龋和釉质龋的检测进行了独立荟萃分析,结果显示灵敏度分别为 0.84(0.80 - 0.87)和 0.71(0.66 - 0.75)。尽管人工智能模型的诊断性能很好,但缺乏高质量、充分报告和外部验证的研究凸显了当前的挑战和未来的研究需求。
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引用次数: 0
Treatment strategies for dental implant removal: A literature review 拔除牙种植体的治疗策略:文献综述
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-23 DOI: 10.1016/j.jdsr.2024.01.002
Chihiro Masaki, Yusuke Kondo, Kei Tomoeda, Tomotaka Nodai, Takashi Munemasa, Taro Mukaibo, Ryuji Hosokawa

Dental implants have been widely used with success, but long-term usage sometimes leads to implant loss. The purpose of this review was to summarize the etiology of early and late failure requiring dental implant removal and the treatment strategies for the removal of failed implants and reimplantation. Early failures are often caused by patient-related factors, such as smoking, diabetes, radiotherapy, bone quality, and periodontitis of the remaining natural teeth. The most common cause of late failure is peri-implantitis, followed by implant fracture and implant malpositioning. Implants should be removed if they are mobile or if their superstructure cannot be maintained (e.g., implant fracture). For peri-implantitis, implant removal should be determined based on the patient’s age and esthetic needs, the implant site, and the severity of bone loss. Many reports have been published on implant removal techniques. The reverse torque technique should always be the first choice because of its low invasiveness. The weighted survival rate for the replacement of failed implants is 86.3%, with a much lower survival rate after the second or subsequent implantations. Therefore, patient-specific problems, such as smoking habits and bruxism, should be checked before reimplantation and controlled to the greatest extent possible.

种植牙已被广泛使用并取得成功,但长期使用有时会导致种植体脱落。本综述旨在总结需要拔除牙种植体的早期和晚期失败的病因,以及拔除失败种植体并重新种植的治疗策略。早期失败通常是由患者相关因素造成的,如吸烟、糖尿病、放疗、骨质、剩余天然牙的牙周炎等。晚期失败最常见的原因是种植体周围炎,其次是种植体断裂和种植体定位不当。如果种植体移动或其上部结构无法维持(如种植体断裂),则应将其拔除。对于种植体周围炎,应根据患者的年龄、美学需求、种植部位和骨质流失的严重程度来决定是否拔除种植体。有关种植体拔除技术的报道很多。反向扭力技术因其创伤小而始终是首选。更换失败种植体的加权存活率为 86.3%,第二次或后续种植体植入后的存活率要低得多。因此,在再次种植前应检查患者的具体问题,如吸烟习惯和磨牙症,并尽可能加以控制。
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引用次数: 0
In vivo dynamics of hard tissue-forming cell origins: Insights from Cre/loxP-based cell lineage tracing studies 硬组织形成细胞起源的体内动态:基于Cre/loxP的细胞系追踪研究的启示
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-20 DOI: 10.1016/j.jdsr.2024.01.003
Toshihide Mizoguchi

Bone tissue provides structural support for our bodies, with the inner bone marrow (BM) acting as a hematopoietic organ. Within the BM tissue, two types of stem cells play crucial roles: mesenchymal stem cells (MSCs) (or skeletal stem cells) and hematopoietic stem cells (HSCs). These stem cells are intricately connected, where BM-MSCs give rise to bone-forming osteoblasts and serve as essential components in the BM microenvironment for sustaining HSCs. Despite the mid-20th century proposal of BM-MSCs, their in vivo identification remained elusive owing to a lack of tools for analyzing stemness, specifically self-renewal and multipotency. To address this challenge, Cre/loxP-based cell lineage tracing analyses are being employed. This technology facilitated the in vivo labeling of specific cells, enabling the tracking of their lineage, determining their stemness, and providing a deeper understanding of the in vivo dynamics governing stem cell populations responsible for maintaining hard tissues. This review delves into cell lineage tracing studies conducted using commonly employed genetically modified mice expressing Cre under the influence of LepR, Gli1, and Axin2 genes. These studies focus on research fields spanning long bones and oral/maxillofacial hard tissues, offering insights into the in vivo dynamics of stem cell populations crucial for hard tissue homeostasis.

骨组织为我们的身体提供结构支撑,其内部的骨髓(BM)是一个造血器官。在骨髓组织内,两种干细胞发挥着关键作用:间充质干细胞(MSCs)(或骨骼干细胞)和造血干细胞(HSCs)。这些干细胞之间有着错综复杂的联系,其中间充质干细胞可产生成骨细胞,而造血干细胞则是间充质干细胞微环境的重要组成部分。尽管 20 世纪中期就有人提出了 BM-间充质干细胞,但由于缺乏分析干性(特别是自我更新和多能性)的工具,体内鉴定 BM-间充质干细胞的工作仍难以开展。为了应对这一挑战,人们采用了基于Cre/loxP的细胞系追踪分析。这项技术有助于对特定细胞进行体内标记,从而追踪细胞系,确定细胞的干性,更深入地了解负责维持硬组织的干细胞群的体内动态。本综述深入探讨了在LepR、Gli1和Axin2基因影响下,使用表达Cre的常用转基因小鼠进行的细胞系追踪研究。这些研究集中于长骨和口腔/颌面部硬组织的研究领域,深入探讨了对硬组织稳态至关重要的干细胞群的体内动态。
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引用次数: 0
Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges 间充质干细胞/基质细胞在牙周再生中的应用:机遇与挑战
IF 6.6 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-01-25 DOI: 10.1016/j.jdsr.2024.01.001
Pan Gao , Mikihito Kajiya , Souta Motoike , Makoto Ikeya , Jingmei Yang

Guided tissue regeneration (GTR) has been widely used in the periodontal treatment of intrabony and furcation defects for nearly four decades. The treatment outcomes have shown effectiveness in reducing pocket depth, improving attachment gain and bone filling in periodontal tissue. Although applying GTR could reconstruct the periodontal tissue, the surgical indications are relatively narrow, and some complications and race ethic problems bring new challenges. Therefore, it is challenging to achieve a consensus concerning the clinical benefits of GTR. With the appearance of stem cell-based regenerative medicine, mesenchymal stem/stromal cells (MSCs) have been considered a promising cell resource for periodontal regeneration. In this review, we highlight preclinical and clinical periodontal regeneration using MSCs derived from distinct origins, including non-odontogenic and odontogenic tissues and induced pluripotent stem cells, and discuss the transplantation procedures, therapeutic mechanisms, and concerns to evaluate the effectiveness of MSCs.

近四十年来,引导组织再生技术(GTR)已被广泛应用于牙周治疗骨内和毛面缺损。治疗结果表明,其在减少牙周袋深度、改善附着增量和牙周组织骨充填方面具有良好的效果。虽然应用 GTR 可以重建牙周组织,但手术适应症相对较窄,一些并发症和种族伦理问题带来了新的挑战。因此,就 GTR 的临床益处达成共识具有挑战性。随着以干细胞为基础的再生医学的出现,间充质干/基质细胞(MSCs)被认为是牙周再生的一种有前景的细胞资源。在这篇综述中,我们重点介绍了利用不同来源的间充质干细胞(包括非牙本质组织和牙本质组织以及诱导多能干细胞)进行牙周再生的临床前和临床研究,并讨论了间充质干细胞的移植程序、治疗机制以及评估其有效性的关注点。
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Japanese Dental Science Review
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