Japanese Dental Science Review最新文献_第3页

Utilization of cellulose nanofiber in dental applications: A systematic review of in vitro evidence 纤维素纳米纤维在牙科应用中的应用：体外证据的系统综述

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-05-31 DOI: 10.1016/j.jdsr.2025.05.002

Kunhua Yang , Alexander Patera Nugraha , Junduo Chen , Hui Yang , Jingyu Wang , Juan Ramón Vanegas Sáenz , Guang Hong

This systematic review aimed to determine how cellulose nanofiber (CNF) enhance the mechanical properties, biocompatibility, and functional versatility of dental materials, based on in vitro evidence. A systematic review protocol was developed according to PRISMA 2020. The literature search was conducted using MEDLINE/PubMed, Scopus, Web of Science, Scopus, and Embase for English-language publications with no date restrictions, yielding 180 publications. After removing duplicates, 150 remained, from which 23 were evaluated in full. 17 in vitro studies met the inclusion criteria, of which 13 had a low risk of bias, 4 had a moderate risk, and none had a high risk. Across all included investigations, CNF consistently improved mechanical performance, particularly flexural and compressive strength, while maintaining or enhancing biocompatibility in various cell culture models. CNF’s nanofibrillar structure and modifiable surface chemistry also expanded its functional versatility, enabling applications such as drug encapsulation and targeted antimicrobial delivery. Overall, CNF emerges as a promising biomaterial for modern dentistry, offering superior mechanical reinforcement, favorable cell responses, and wide-ranging functional modifications. Further in vivo research and clinical trials are necessary to confirm its long-term safety and efficacy, thereby facilitating the translation of these in vitro findings into standard dental practice.

本系统综述旨在确定纤维素纳米纤维（CNF）如何增强牙科材料的机械性能、生物相容性和功能通用性，基于体外证据。根据PRISMA 2020制定了系统审查方案。文献检索使用MEDLINE/PubMed、Scopus、Web of Science、Scopus和Embase对无日期限制的英文出版物进行检索，共检索到180篇出版物。去除重复项后，剩下150项，其中23项被完全评估。17项体外研究符合纳入标准，其中13项为低偏倚风险，4项为中等偏倚风险，无高风险。在所有包括的研究中，CNF持续改善机械性能，特别是弯曲和抗压强度，同时保持或增强各种细胞培养模型的生物相容性。CNF的纳米纤维结构和可修饰的表面化学也扩展了其功能的多功能性，使其能够应用于药物封装和靶向抗菌药物输送等领域。总的来说，CNF作为一种有前途的现代牙科生物材料，提供优越的机械加固，有利的细胞反应和广泛的功能修饰。进一步的体内研究和临床试验是必要的，以确认其长期安全性和有效性，从而促进这些体外研究结果转化为标准的牙科实践。

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引用次数: 0

Impact of active vs. passive application of dental adhesives on bond strength to dentin and enamel: A systematic review and meta-analysis of in vitro studies 主动与被动应用牙胶粘剂对牙本质和牙釉质结合强度的影响：体外研究的系统回顾和荟萃分析

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-05-01 DOI: 10.1016/j.jdsr.2025.04.001

Gabriela Luiza Moreira Carvalho , Paulo Matias Moreira , Bruna Tavares Carneiro , Thais Yumi Umeda Suzuki , Marcos Daniel Septímio Lanza , Hugo Henriques Alvim , Marcelo Giannini , Carolina Bosso Andre

The application method of adhesive systems affects both immediate and long-term bond strength. This systematic review analyzed in vitro studies comparing active versus passive application of adhesives on enamel and dentin, regardless of classification. A comprehensive search was conducted in PubMed/Medline, Embase, Scopus, Web of Science, Lilacs, and Grey Literature. Included studies assessed bond strength with active or passive application. Meta-analyses were stratified by substrate (enamel and dentin) and application mode (etch-and-rinse or self-etching), using a random-effects model and I² index for heterogeneity. The RobDEMAT tool assessed the risk of bias. Out of 3022 articles, 23 met the inclusion criteria. Meta-analysis showed that passive application of universal adhesives in etch-and-rinse mode resulted in higher bond strength to enamel. However, active application of etch-and-rinse or universal adhesives in etch-and-rinse mode improved bond strength on dentin. For self-etching or universal adhesives in self-etching mode, active application enhanced bond strength on both enamel and dentin. Few studies assessed longevity, but those that did reported positive outcomes for active application. One self-curing universal adhesive showed significantly different results. In conclusion, active application improves bond strength to dentin in two-step etch-and-rinse mode and to unconditioned enamel and dentin in self-etching mode.

胶粘剂系统的应用方法会影响当前和长期的粘接强度。这篇系统综述分析了在体外的研究，比较了在牙釉质和牙本质上使用粘合剂的主动和被动应用，而不考虑分类。在PubMed/Medline、Embase、Scopus、Web of Science、Lilacs和Grey Literature中进行了全面的检索。纳入的研究评估了主动或被动应用的粘结强度。meta分析采用随机效应模型和I²异质性指数，按基质（牙釉质和牙本质）和应用模式（蚀刻-冲洗或自蚀刻）进行分层。RobDEMAT工具评估偏倚风险。在3022篇文章中，23篇符合纳入标准。荟萃分析显示，在蚀刻-冲洗模式下被动应用通用粘合剂可以提高牙釉质的结合强度。然而，主动应用蚀刻-冲洗或通用粘合剂在蚀刻-冲洗模式提高了牙本质的结合强度。对于自蚀刻或自蚀刻模式的通用胶粘剂，主动应用增强了牙釉质和牙本质的结合强度。很少有研究评估寿命，但那些确实报告了积极应用的积极结果。一种自固化万能胶效果有显著差异。综上所述，主动应用提高了两步蚀刻-冲洗模式下牙本质的结合强度，以及自蚀刻模式下无条件牙釉质和牙本质的结合强度。

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引用次数: 0

Learning Styles in undergraduate dentistry students: A systematic review 牙科本科学生的学习风格：系统回顾

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-04-08 DOI: 10.1016/j.jdsr.2025.03.004

N. Ferrer-Valdivia , V. Herrera-Barraza , C. Garrido-Urrutia

Objective

To evaluate the prevalence of Learning Styles (LS) among undergraduate dentistry students (UDS),

Method

Cochrane manual’s methodology and PRISMA statement were used. Four databases were searched, and the studies were selected based on eligibility criteria. The search strategy was Learning Style AND Dentistry and Learning Style AND dental student.

Results

A total of 30 articles were included, 17 of which used the Visual, Aural, Read-write and Kinesthetic (VARK) questionnaire, 8 the Kolb LS Inventory (LSI), 3 the Honey-Alonso questionnaire (CHAEA) and 3 the Felder and Solomon LS index (ILS). The studies that allowed us to extract all the necessary data to calculate the global percentages for each instrument were grouped together. For VARK, LSI, CHAEA and ILS the highest number and percentage of learning styles were 1089 (50.4 %) multimodal, 518 (32.7 %) divergent, 239 (46.7 %) reflectors and 107 (64.8 %) active, 130 (78.8 %) sensitive, 138 (83.6 %) visual and 106 (64.3 %) sequential, respectively.

Conclusions

There is a tendency for multimodal, divergent and reflective LS to increase among clinical students, unlike initial and preclinical dentistry students, who lean towards unimodal, convergent and theoretical LS. This dynamism in LS could be influenced by the different methodologies strategies used in the preclinical and clinical courses.

目的评估牙科本科学生学习风格（LS）的流行情况，方法采用cochrane手册方法学和PRISMA量表。检索了四个数据库，并根据入选标准选择了研究。搜索策略是学习风格和牙科以及学习风格和牙科学生。结果共纳入30篇文献，其中17篇采用视觉、听觉、读写和动觉量表（VARK）， 8篇采用Kolb LS量表（LSI）， 3篇采用Honey-Alonso问卷（CHAEA）， 3篇采用Felder and Solomon LS指数（ILS）。使我们能够提取所有必要数据以计算每种工具的全球百分比的研究被分组在一起。VARK、LSI、CHAEA和ILS的学习风格数量和百分比分别为：多模态1089（50.4 %）、发散型518（32.7 %）、反射型239（46.7 %）、主动型107（64.8 %）、敏感型130（78.8 %）、视觉型138（83.6 %）和顺序型106（64.3 %）。结论临床生多模态、发散性和反思性LS倾向增加，而初学和临床预科生倾向于单模态、收敛性和理论性LS。这种动态在LS可能会受到临床前和临床课程中使用的不同方法策略的影响。

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引用次数: 0

Nanoidentification in endodontics: Bibliometric analysis and comprehensive review on the basis of characterisation research by Nano-computed tomography imaging 牙髓学中的纳米鉴定：文献计量学分析和基于纳米计算机断层成像表征研究的综合综述

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-03-24 DOI: 10.1016/j.jdsr.2025.03.003

Olcay Özdemir , Sena Kaşıkçı , Turkan Kopac

Nanoimaging, crucial in endodontics, has advanced, leading to more effective and less invasive treatments. Nano-computed tomography (nano-CT) is an advanced imaging technique to evaluate bone structures or gaps in filling materials, providing submicrometer spatial resolution due to smaller focal points and voxels, higher signal-to-noise ratios, and higher tube voltages and powers compared to conventional devices, improving dental imaging precision and safety by producing detailed images with minimal radiation exposure. This study conducted a bibliometric analysis on nano-CT imaging as a nano identification tool in endodontics. Using various tools and methods, it evaluated progress and trends in nano-CT, aiming to enhance understanding of bibliometric data and complement existing endodontic knowledge. Nano-CT imaging has gained prominence in endodontics research, offering potential applications and insights into various aspects of the field. A review of relevant studies highlighted the technique's ability to visualize dentin tubules, root canal anatomy, filling quality, root resorption, cracks, microcracks, soft dental tissues, cellular layers, volumetric changes post-instrumentation, hard tissue debris, root surface deposits, and bioceramic pore structures. Nano-CT has the potential to become the gold standard for imaging in endodontics, presenting opportunities and challenges for future research. These findings provide researchers and practitioners with the latest advancements in nanoimaging.

纳米成像技术在牙髓学中发挥着至关重要的作用，它已经取得了进展，导致了更有效和更少侵入性的治疗。纳米计算机断层扫描（纳米ct）是一种先进的成像技术，用于评估骨结构或填充材料中的间隙，与传统设备相比，由于更小的焦点和体素，更高的信噪比，更高的管电压和功率，提供亚微米的空间分辨率，通过产生最小辐射暴露的详细图像来提高牙科成像精度和安全性。本研究对纳米ct成像作为牙髓学纳米识别工具进行了文献计量学分析。使用各种工具和方法，评估纳米ct的进展和趋势，旨在加强对文献计量数据的理解，并补充现有的牙髓学知识。纳米ct成像在牙髓学研究中获得了突出的地位，为该领域的各个方面提供了潜在的应用和见解。相关研究综述强调了该技术能够可视化牙本质小管、根管解剖、填充质量、根吸收、裂缝、微裂缝、软牙组织、细胞层、仪器后体积变化、硬组织碎片、根表面沉积物和生物陶瓷孔结构。纳米ct有可能成为牙髓学成像的黄金标准，为未来的研究带来机遇和挑战。这些发现为研究人员和从业人员提供了纳米成像的最新进展。

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引用次数: 0

Micro- and nano-scale adhesion of oral bacteria to biomaterials using atomic force microscopy: A systematic review 用原子力显微镜观察口腔细菌与生物材料的微观和纳米级粘附：系统综述

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-03-17 DOI: 10.1016/j.jdsr.2025.03.002

Antonia Olivares , Valentina Barraza , Sebastian Aguayo

To evaluate the available evidence regarding in-vitro studies carried out with atomic force microscopy (AFM) to study the adhesion of oral bacteria under the research question: “Which adhesion parameters have been reported for oral bacteria attachment to surfaces following AFM experiments?”

This review was carried out following PRISMA guidelines. The Pubmed, Web of Science and Scopus databases were accessed and original articles reporting in-vitro findings on AFM-based oral bacteria adhesion experiments were included. Study selection and data extraction was performed by two independent researchers. Of the initial 249 screened articles, 24 were included in the final analysis.

Overall, the adhesion of oral bacteria to 12 different biomaterial surface types has been explored with AFM including soft materials, dental materials, and other materials. S. mutans was the most frequently studied bacterial species in its early attachment to biomaterials. Regarding AFM-based adhesion parameters, the maximum adhesion force, adhesion energy, rupture and contour lengths, and number of rupture events between oral bacteria and substrates have been quantified and reported.

Initial oral bacterial attachment to biomaterials is modulated by a range of cell, environmental, and surface-derived properties. Further research is needed to transfer this knowledge into the clinical setting.

为了评估利用原子力显微镜（AFM）研究口腔细菌粘附的体外研究的现有证据，研究问题是：“在原子力显微镜实验后，哪些粘附参数被报道为口腔细菌附着于表面？”这项审查是按照PRISMA的指导方针进行的。我们访问了Pubmed、Web of Science和Scopus数据库，并纳入了基于afm的口腔细菌粘附实验的体外实验结果的原创文章。研究选择和数据提取由两名独立研究人员进行。在最初筛选的249篇文章中，有24篇被纳入最终分析。总的来说，用AFM研究了口腔细菌对12种不同生物材料表面类型的粘附，包括软性材料、牙科材料和其他材料。变形链球菌是最常研究的细菌种类，在其早期附着于生物材料。关于基于afm的粘附参数，口腔细菌与底物之间的最大粘附力、粘附能、破裂和轮廓长度以及破裂事件数已被量化并报道。口腔细菌对生物材料的初始附着受到一系列细胞、环境和表面衍生特性的调节。需要进一步的研究将这些知识应用到临床环境中。

{"title":"Micro- and nano-scale adhesion of oral bacteria to biomaterials using atomic force microscopy: A systematic review","authors":"Antonia Olivares , Valentina Barraza , Sebastian Aguayo","doi":"10.1016/j.jdsr.2025.03.002","DOIUrl":"10.1016/j.jdsr.2025.03.002","url":null,"abstract":"<div><div>To evaluate the available evidence regarding in-vitro studies carried out with atomic force microscopy (AFM) to study the adhesion of oral bacteria under the research question: <em>“Which adhesion parameters have been reported for oral bacteria attachment to surfaces following AFM experiments?”</em></div><div>This review was carried out following PRISMA guidelines. The Pubmed, Web of Science and Scopus databases were accessed and original articles reporting in-vitro findings on AFM-based oral bacteria adhesion experiments were included. Study selection and data extraction was performed by two independent researchers. Of the initial 249 screened articles, 24 were included in the final analysis.</div><div>Overall, the adhesion of oral bacteria to 12 different biomaterial surface types has been explored with AFM including soft materials, dental materials, and other materials. <em>S. mutans</em> was the most frequently studied bacterial species in its early attachment to biomaterials. Regarding AFM-based adhesion parameters, the maximum adhesion force, adhesion energy, rupture and contour lengths, and number of rupture events between oral bacteria and substrates have been quantified and reported.</div><div>Initial oral bacterial attachment to biomaterials is modulated by a range of cell, environmental, and surface-derived properties. Further research is needed to transfer this knowledge into the clinical setting.</div></div>","PeriodicalId":51334,"journal":{"name":"Japanese Dental Science Review","volume":"61 ","pages":"Pages 41-54"},"PeriodicalIF":5.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of different interventions on the morbidity of the palatal donor area after free gingival graft and connective tissue graft: A systematic review 不同干预措施对游离龈移植和结缔组织移植后腭供区发病率的影响：系统综述

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-03-12 DOI: 10.1016/j.jdsr.2025.03.001

Gabriel Guimarães Leite , Karolina Skarlet Silva Viana , Luís Otávio Miranda Cota , Lucas Guimarães Abreu , Rafael Paschoal Esteves Lima , Fernando Oliveira Costa

This review aimed to evaluate the efficacy of different interventions used on the palatal donor area in the treatment of postoperative pain after free gingival graft and connective tissue graft techniques, and their impact in the oral-health related quality of life (OHRQOL). This study was conducted according to PRISMA. A search was conducted in four electronic databases and the grey literature. The interventions found were grouped according to biological plausibility and mechanisms of action: Mechanical Barriers; Topical Drugs; Hemostatic Agents; Other Therapies (photobiomodulation, ozonotherapy and others). Fifty-four studies were included and 43 different interventions were reported. The most commonly reported intervention was collagen hemostatic sponge, either alone or combined with other interventions, followed by platelet-rich fibrin and photobiomodulation. Postoperative pain evaluation using the Visual Analogue Scale (VAS) generally indicated that interventions improved pain over time. However, comparing the superiority of interventions is challenging, as studies often combine different interventions with different mechanisms of action. OHRQOL also showed improvement over time, but the comparison between interventions is limited, since few studies used a validated tool. The methodological diversity among studies is considerable, requiring a cautious interpretation of individual studies.

本综述旨在评价腭供区不同干预措施治疗游离龈移植和结缔组织移植术后疼痛的疗效及其对口腔健康相关生活质量（OHRQOL）的影响。本研究根据PRISMA进行。在四个电子数据库和灰色文献中进行了检索。所发现的干预措施根据生物学合理性和作用机制进行分组：机械障碍；局部药物;止血剂;其他疗法（光生物调节、臭氧疗法等）。共纳入54项研究，报告了43种不同的干预措施。最常见的干预措施是胶原止血海绵，单独或联合其他干预措施，其次是富血小板纤维蛋白和光生物调节。术后疼痛评估使用视觉模拟量表（VAS）一般表明干预措施改善疼痛随着时间的推移。然而，比较干预措施的优势是具有挑战性的，因为研究经常将不同的干预措施与不同的作用机制结合起来。随着时间的推移，OHRQOL也显示出改善，但干预措施之间的比较有限，因为很少有研究使用经过验证的工具。研究方法的多样性相当大，需要对个别研究进行谨慎的解释。

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引用次数: 0

Role of genetic polymorphisms in residual ridge resorption of mandible – A scoping review 遗传多态性在下颌骨残脊吸收中的作用——综述

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-03-04 DOI: 10.1016/j.jdsr.2025.02.002

Swapna B. Venkatesh , Smitha Sammith Shetty

Residual ridge (RR) refers to the clinical alveolar ridge that remains after the bone and soft tissues have healed following tooth extraction. This ridge undergoes resorption, which is most rapid during the first six months of post-extraction. Subsequently, bone resorption continues at a slower pace throughout life, leading to significant loss of jaw structure over time. This process is commonly known as residual ridge resorption (RRR). RRR is a major factor contributing to the loss of stability and retention, especially in mandibular complete dentures. Severe resorption of the maxillary and mandibular ridges can also lead to a sunken cheek appearance, poorly fitting and unstable dentures, and associated pain and discomfort. Though the etiology of residual ridge resorption remains unclear. It is believed that certain cytokines and individual genetic variations may influence the RRR process. Thus, reviewing the studies that discuss genetic association with the health and resorption of alveolar bone may give clear view on the etiology, help to define the risk and strategize preventive and personalized management of the disease. Hence, we undertook a scoping review to understand the potential genetic factors influencing the Residual ridge resorption (RRR). This review employed PRISMA-ScR extension protocols for scoping review. The results of the study provided significant association between genetic polymorphisms, especially of single gene nucleotide polymorphisms with mandibular residual ridge resorption. Hence understanding the genetic predisposition of patients can guide the clinicians in identifying patients at higher risk of RRR, enabling preventive measures, proactive intervention and careful designing of the prothesis.

残牙脊（RR）是指拔牙后骨和软组织愈合后残留的临床牙槽嵴。在拔牙后的前6个月，牙脊吸收最为迅速。随后，骨吸收在整个生命过程中以较慢的速度继续，随着时间的推移导致颌骨结构的显著丧失。这个过程通常被称为残余脊吸收（RRR）。RRR是导致下颌全口义齿失稳和固位的主要因素。上颌和下颌嵴的严重吸收也会导致面颊凹陷，假牙不合适和不稳定，以及相关的疼痛和不适。尽管残脊吸收的病因尚不清楚。人们认为某些细胞因子和个体遗传变异可能影响RRR过程。因此，回顾讨论遗传与牙槽骨健康和吸收的关系的研究，可以清楚地了解病因，有助于确定风险，制定预防和个性化治疗策略。因此，我们进行了范围综述，以了解影响残脊吸收（RRR）的潜在遗传因素。本综述采用PRISMA-ScR扩展协议进行范围审查。研究结果表明遗传多态性，特别是单基因核苷酸多态性与下颌残脊吸收之间存在显著关联。因此，了解患者的遗传易感性可以指导临床医生识别RRR高危患者，采取预防措施，积极干预，精心设计假体。

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引用次数: 0

Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis 牙菌斑引起的口腔疾病与炎症性肠病之间的双向关联：一项系统综述和荟萃分析

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-02-18 DOI: 10.1016/j.jdsr.2025.02.001

Yuqing Zhang , Ce Bian , Chaoran Yu , Mengyao Zhu , Michael D. Weir , Hockin H.K. Xu , Yuxing Bai , Ning Zhang

The bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web of Science, and the Cochrane Library from inception to August 2024 to identify relevant studies. The relative risk (RR) from periodontal disease studies and the decayed, missing, and filled teeth (DMFT) index from caries-related studies was pooled, and calculating 95 % confidence intervals (CIs). Subgroup analysis, sensitivity analysis, and cumulative meta-analysis were employed to evaluate the robustness of the findings. The research adhered to PRISMA 2020 guidelines, incorporating 26 studies for systematic review and 20 for meta-analysis. The results indicated no significant increase in the overall risk of inflammatory bowel disease (IBD) in patients with periodontal disease (RR 1.31, 95 % CI 0.98–1.35); however, the risk of ulcerative colitis (UC) was higher compared to controls (RR 1.34, 95 % CI 1.04–1.73). Among IBD patients, the risk of periodontal disease was significantly elevated (RR 2.14, 95 % CI 1.62–2.81), as was the risk of dental caries (WMD = 2.51, 95 % CI 0.97–4.06). Additionally, UC patients exhibited a higher incidence of caries compared to Crohn’s disease (CD) patients (WMD = 3.97, 95 % CI 1.94–6.00). Sensitivity analyses and cumulative meta-analyses confirmed the stability of the results. In conclusion, IBD patients, particularly those with UC, should prioritize stringent oral hygiene to mitigate the risks of periodontal disease and dental caries. The association between periodontal disease and IBD warrants further investigation, and high-quality clinical studies are needed to provide more definitive and reliable evidence.

牙菌斑引起的口腔疾病与炎症性肠病之间的双向关联尚不清楚。在这里，我们全面检索了PubMed， EMBASE， Web of Science和Cochrane Library从成立到2024年8月的相关研究。将来自牙周病研究的相对危险度（RR）和来自龋齿相关研究的蛀牙、缺牙和补牙（DMFT）指数汇总，并计算95% %置信区间（ci）。采用亚组分析、敏感性分析和累积荟萃分析来评估研究结果的稳健性。该研究遵循PRISMA 2020指南，纳入26项研究进行系统评价，20项进行荟萃分析。结果显示，牙周病患者患炎症性肠病（IBD）的总体风险没有显著增加（RR 1.31, 95 % CI 0.98-1.35）；然而，溃疡性结肠炎（UC）的风险高于对照组（RR 1.34, 95 % CI 1.04-1.73）。在IBD患者中，牙周病的风险显著升高（RR 2.14, 95 % CI 1.62-2.81），龋齿的风险也显著升高（WMD = 2.51, 95 % CI 0.97-4.06）。此外，UC患者的龋齿发生率高于克罗恩病（CD）患者（WMD = 3.97, 95 % CI 1.94-6.00）。敏感性分析和累积荟萃分析证实了结果的稳定性。总之，IBD患者，特别是UC患者，应优先考虑严格的口腔卫生，以降低牙周病和龋齿的风险。牙周病和IBD之间的关系需要进一步调查，需要高质量的临床研究来提供更明确和可靠的证据。

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引用次数: 0

Challenges in dental education: A call for critical dialogue 牙科教育的挑战：呼吁进行批判性对话。

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review

Pub Date : 2025-01-17 DOI: 10.1016/j.jdsr.2025.01.001

Juliana Cassol Spanemberg, Vinicius Coelho Carrard