Pub Date : 2025-09-01DOI: 10.1016/j.cjtee.2024.02.008
Sammy Al-Benna
{"title":"ACE2 gene expression in skin and subcutaneous tissues of free flaps","authors":"Sammy Al-Benna","doi":"10.1016/j.cjtee.2024.02.008","DOIUrl":"10.1016/j.cjtee.2024.02.008","url":null,"abstract":"","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 5","pages":"Page 385"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.cjtee.2024.12.003
Ye Zhou , Ming-Jun Liu , Xiao Lin , Jin-Hua Jiang , Hui-Chang Zhuo
<div><h3>Purpose</h3><div>To compare the efficacy of continuous renal replacement therapy (CRRT) using either oXiris or conventional hemopurification filters in the treatment of intra-abdominal sepsis.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of septic patients with severe intra-abdominal infections admitted to our hospital from October 2019 to August 2023. Patients who meet the criteria for intra-abdominal sepsis based on medical history, symptoms, physical examination, and laboratory/imaging findings were included. Exclusion criteria: pregnancy, terminal malignancy, prior CRRT before intensive care unit admission, pre-existing liver or renal failure. Heart rate (HR), mean arterial pressure, oxygenation index, lactic acid level (Lac), platelet count (PLT), neutrophil percentage, serum levels of procalcitonin, C-reactive protein, interleukin (IL)-6, norepinephrine dosage, acute physiology and chronic health evaluation II (APACHE II), and sequential organ failure assessment (SOFA) scores before and after 24 h and 72 h of treatment, as well as ventilator use time, hemopurification treatment time, intensive care unit and hospital lengths of stay, and 14-day and 28-day mortality were compared between patients receiving CRRT using either oXiris or conventional hemofiltration. Statistical analysis was performed using SPSS Statistics 26.0 software, including the construction of predictive models via logistic regression equations and repeated measures ANOVA.</div></div><div><h3>Results</h3><div>Baseline values including time to antibiotic administration, time to source control, and time to initiation of CRRT were similar between the 2 groups (all <em>p</em>>0.05). Patients receiving conventional CRRT exhibited significant changes in HR but of none of the other indexes at the 24 h and 72 h time points (<em>p</em>=0.041, <em>p</em>=0.026, respectively). The oXiris group showed significant improvements in HR, Lac, IL-6, and APACHE II score 24 h after treatment (<em>p</em><0.05); after 72 h, all indexes were improved except PLT (all <em>p</em><0.05). Intergroup comparison disclosed significant differences in HR, Lac, norepinephrine dose, APACHE II, SOFA, neutrophil percentage, and IL-6 after 24 h of treatment (<em>p</em><0.05). Mean arterial pressure, serum levels of procalcitonin, C-reactive protein, SOFA score, and norepinephrine dosage were similar between the 2 groups at 24 h (<em>p</em>>0.05). Except for HR, oxygenation index, and PLT, post-treatment change rates of △ (%) were significantly greater in the oXiris group (<em>p</em> < 0.05). Duration of ventilator use, CRRT time, and intensive care unit and hospital lengths of stay were similar between the 2 groups (<em>p</em>>0.05). The 14-day mortality rates of the 2 groups were similar (<em>p</em>=0.091). After excluding patients whose CRRT was interrupted, 28-day mortality was significantly lower in the oXiris than in the conventional group (25.0%
{"title":"Comparative efficacy of two hemopurification filters for treating intra-abdominal sepsis: A retrospective study","authors":"Ye Zhou , Ming-Jun Liu , Xiao Lin , Jin-Hua Jiang , Hui-Chang Zhuo","doi":"10.1016/j.cjtee.2024.12.003","DOIUrl":"10.1016/j.cjtee.2024.12.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the efficacy of continuous renal replacement therapy (CRRT) using either oXiris or conventional hemopurification filters in the treatment of intra-abdominal sepsis.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of septic patients with severe intra-abdominal infections admitted to our hospital from October 2019 to August 2023. Patients who meet the criteria for intra-abdominal sepsis based on medical history, symptoms, physical examination, and laboratory/imaging findings were included. Exclusion criteria: pregnancy, terminal malignancy, prior CRRT before intensive care unit admission, pre-existing liver or renal failure. Heart rate (HR), mean arterial pressure, oxygenation index, lactic acid level (Lac), platelet count (PLT), neutrophil percentage, serum levels of procalcitonin, C-reactive protein, interleukin (IL)-6, norepinephrine dosage, acute physiology and chronic health evaluation II (APACHE II), and sequential organ failure assessment (SOFA) scores before and after 24 h and 72 h of treatment, as well as ventilator use time, hemopurification treatment time, intensive care unit and hospital lengths of stay, and 14-day and 28-day mortality were compared between patients receiving CRRT using either oXiris or conventional hemofiltration. Statistical analysis was performed using SPSS Statistics 26.0 software, including the construction of predictive models via logistic regression equations and repeated measures ANOVA.</div></div><div><h3>Results</h3><div>Baseline values including time to antibiotic administration, time to source control, and time to initiation of CRRT were similar between the 2 groups (all <em>p</em>>0.05). Patients receiving conventional CRRT exhibited significant changes in HR but of none of the other indexes at the 24 h and 72 h time points (<em>p</em>=0.041, <em>p</em>=0.026, respectively). The oXiris group showed significant improvements in HR, Lac, IL-6, and APACHE II score 24 h after treatment (<em>p</em><0.05); after 72 h, all indexes were improved except PLT (all <em>p</em><0.05). Intergroup comparison disclosed significant differences in HR, Lac, norepinephrine dose, APACHE II, SOFA, neutrophil percentage, and IL-6 after 24 h of treatment (<em>p</em><0.05). Mean arterial pressure, serum levels of procalcitonin, C-reactive protein, SOFA score, and norepinephrine dosage were similar between the 2 groups at 24 h (<em>p</em>>0.05). Except for HR, oxygenation index, and PLT, post-treatment change rates of △ (%) were significantly greater in the oXiris group (<em>p</em> < 0.05). Duration of ventilator use, CRRT time, and intensive care unit and hospital lengths of stay were similar between the 2 groups (<em>p</em>>0.05). The 14-day mortality rates of the 2 groups were similar (<em>p</em>=0.091). After excluding patients whose CRRT was interrupted, 28-day mortality was significantly lower in the oXiris than in the conventional group (25.0% ","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 5","pages":"Pages 352-360"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-28DOI: 10.1016/j.cjtee.2025.02.009
Huan Wang, Qing-Da Lu, Chen-Xin Liu, Xiao-Ju Liang, Fei Su, Ya-Ting Yang, Ji-Ning Qu, Jia-Ju Wang, Qiang Jie
Purpose: This review provides guidance and ideas for researchers through a comprehensive and comparative analysis of the present state, trends, and hotspots in the epiphyseal injury literature in the last 2 decades.
Methods: We searched the Web of Science core database to explore the epiphyseal injury literature from January 1, 2003 to December 31, 2022. (1) Search parameters: #1.TS = "epiphysis" or "epiphyseal" or "growth plate"; #2.TS = "injury" or "trauma". (2) Document types: "Article" and "Review"; (3) Time: January 1, 2003-December 31, 2022; (4) Languages: "English". We used Citespace 6.2.R3 software to explore the country/region distribution, institutions, journals, keyword analysis, and co-cited references of the literature.
Results: A total of 2138 relevant literature were obtained, with the number of publications increasing annually. The country with the highest number of publications is the United States. The highest-producing institution was Harvard University. The most cited journal was the Journal of Bone and Joint Surgery-American Volume. The first tag for keyword clustering was the anterior cruciate ligament (ACL). Keyword bursts were found in the recent attention to the words: outcome, physeal fractures, risk factors, fixation, risk, transplantation, and osteoarthritis. The analysis of the literature co-citation found that the topic of ACL and regeneration of epiphysis is a trend in research and high-quality literature in this field.
Conclusions: We can quickly get a sense of the focus and changing trends in epiphyseal injuries through keywords and co-citation reference bursts. The treatment of ACL injuries is a major area of interest for researchers. The most common concerns are MRI assessment of ACL injury reconstruction, comparison of different treatment methods, such as avoiding damage in epiphyseal reconstruction surgery, and associated complications. The analysis of the keywords and the co-citation references revealed that managing risk factors, treatment modalities, and complications related to epiphyseal injury after epiphyseal fracture will be a trend in future research.
目的:通过对近20年来骨骺损伤文献的现状、趋势和热点进行综合比较分析,为研究人员提供指导和思路。方法:检索Web of Science核心数据库,检索2003年1月1日至2022年12月31日有关骨骺损伤的文献。(1)搜索参数:#1。TS =“骨骺”或“骨骺”或“生长板”;# 2。TS =“受伤”或“创伤”。(2)文件类型:“文章”和“综述”;(3)时间:2003年1月1日- 2022年12月31日;(4)语言:“英语”。我们使用了Citespace 6.2。R3软件探索国家/地区分布、机构、期刊、关键词分析、文献共被引。结果:共获得相关文献2138篇,发表次数逐年增加。发表论文最多的国家是美国。产量最高的大学是哈佛大学。被引用最多的期刊是《骨与关节外科杂志-美国卷》。关键词聚类的第一个标签是前交叉韧带(ACL)。在最近的关注中发现关键词爆发:结局、骨骺骨折、危险因素、固定、危险、移植和骨关节炎。通过文献共引分析发现,前交叉韧带与骨骺再生是该领域的研究趋势和高质量文献。结论:通过关键词和共被引文献,可以快速了解骨骺损伤的研究重点和变化趋势。前交叉韧带损伤的治疗是研究人员感兴趣的一个主要领域。最常见的问题是ACL损伤重建的MRI评估,不同治疗方法的比较,如在骨骺重建手术中避免损伤,以及相关并发症。对关键词和共被引文献的分析表明,管理骨骺骨折后骨骺损伤的危险因素、治疗方式和并发症将是未来研究的趋势。
{"title":"Trends and hotspots in epiphyseal injury studies over 2 decades: A bibliometric analysis.","authors":"Huan Wang, Qing-Da Lu, Chen-Xin Liu, Xiao-Ju Liang, Fei Su, Ya-Ting Yang, Ji-Ning Qu, Jia-Ju Wang, Qiang Jie","doi":"10.1016/j.cjtee.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.009","url":null,"abstract":"<p><strong>Purpose: </strong>This review provides guidance and ideas for researchers through a comprehensive and comparative analysis of the present state, trends, and hotspots in the epiphyseal injury literature in the last 2 decades.</p><p><strong>Methods: </strong>We searched the Web of Science core database to explore the epiphyseal injury literature from January 1, 2003 to December 31, 2022. (1) Search parameters: #1.TS = \"epiphysis\" or \"epiphyseal\" or \"growth plate\"; #2.TS = \"injury\" or \"trauma\". (2) Document types: \"Article\" and \"Review\"; (3) Time: January 1, 2003-December 31, 2022; (4) Languages: \"English\". We used Citespace 6.2.R3 software to explore the country/region distribution, institutions, journals, keyword analysis, and co-cited references of the literature.</p><p><strong>Results: </strong>A total of 2138 relevant literature were obtained, with the number of publications increasing annually. The country with the highest number of publications is the United States. The highest-producing institution was Harvard University. The most cited journal was the Journal of Bone and Joint Surgery-American Volume. The first tag for keyword clustering was the anterior cruciate ligament (ACL). Keyword bursts were found in the recent attention to the words: outcome, physeal fractures, risk factors, fixation, risk, transplantation, and osteoarthritis. The analysis of the literature co-citation found that the topic of ACL and regeneration of epiphysis is a trend in research and high-quality literature in this field.</p><p><strong>Conclusions: </strong>We can quickly get a sense of the focus and changing trends in epiphyseal injuries through keywords and co-citation reference bursts. The treatment of ACL injuries is a major area of interest for researchers. The most common concerns are MRI assessment of ACL injury reconstruction, comparison of different treatment methods, such as avoiding damage in epiphyseal reconstruction surgery, and associated complications. The analysis of the keywords and the co-citation references revealed that managing risk factors, treatment modalities, and complications related to epiphyseal injury after epiphyseal fracture will be a trend in future research.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144977974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-25DOI: 10.1016/j.cjtee.2025.04.004
Giora Weiser
Uncontrolled hemorrhage is a leading cause of mortality in trauma. It is considered the most significant preventable cause of death in trauma patients. Junctional hemorrhages are responsible for approximately 20% of this possibly preventable mortality. At this time, the options for controlling such hemorrhages are either by manual pressure points or the use of junctional tourniquets, which, although they have been proven to be effective, are cumbersome and not readily available to the medical team in the field. The objective of this study was to evaluate the effectiveness and feasibility of a new junctional tourniquet (Life Saving Tourniquet, T-W-Medical ltd.) that is simpler to use and can perform both as a regular tourniquet and a junctional one.
不受控制的出血是创伤死亡的主要原因。它被认为是创伤患者中最重要的可预防的死亡原因。在这些本可预防的死亡中,结膜出血约占20%。目前,控制这种出血的办法要么是用手压点,要么是使用结膜止血带,这种方法虽然已被证明是有效的,但很麻烦,外地医疗队不易获得。本研究的目的是评估一种新型结缔组织止血带(Life Saving tourniquet, t - w medical ltd.)的有效性和可行性,该止血带使用更简单,可以同时作为常规止血带和结缔组织止血带。
{"title":"LST-A novel junctional tourniquet: A study of feasibility and effectiveness.","authors":"Giora Weiser","doi":"10.1016/j.cjtee.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.04.004","url":null,"abstract":"<p><p>Uncontrolled hemorrhage is a leading cause of mortality in trauma. It is considered the most significant preventable cause of death in trauma patients. Junctional hemorrhages are responsible for approximately 20% of this possibly preventable mortality. At this time, the options for controlling such hemorrhages are either by manual pressure points or the use of junctional tourniquets, which, although they have been proven to be effective, are cumbersome and not readily available to the medical team in the field. The objective of this study was to evaluate the effectiveness and feasibility of a new junctional tourniquet (Life Saving Tourniquet, T-W-Medical ltd.) that is simpler to use and can perform both as a regular tourniquet and a junctional one.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-23DOI: 10.1016/j.cjtee.2025.01.005
Lina Marcela Sandoval, Andrés Fandiño-Losada, Elvis Siprian Castro-Alzate, Claudio Bustos, Alberto Federico García, Adrián David Fernández
Purpose: The objective of the study was to determine the causal interrelationships between sociodemography, clinic, and injury characteristics, and to access to rehabilitation services that generate disability in road traffic injury survivors in 2 regions of Southwest Colombia during the 2018-2021 period.
Methods: An ambispective cohort study included 261 survivors from road traffic in 2 regions of Southwest Colombia (Cauca and Valle del Cauca) between April 19, 2021 and June 03, 2022. These survivors accepted treatment in 3 high-level comprehensive health institutions in Cali, Colombia, which are regional referral centers for trauma in the region. Patients (1) with hospitalization time ≥12 h, (2) aged ≥18 years, and (3) having the ability to understand the research questionnaires by themselves or their legal representatives, were included. Those with a history of deficiency before the road traffic injury were excluded. A structural equation model of causal pathways of disability was established to estimate exposure variables that are sociodemography, clinic, and access to rehabilitation services. The main outcome variable was disability, estimated by the World Health Organization Disability Assessment Schedule 2.0. Exposure variables related to clinical characteristics were measured through medical record review. The variables of access to rehabilitation services and disability were measured through a telephone-based survey. Structural equation analysis was performed, estimating the mediating effects of disability. The analyses were conducted in the software R Studio® y Mplus®.
Results: The study found a significant gender difference in disability, with women presenting a significantly higher disability than men (β: 6.21; p = 0.041). Disability was also associated with clinical conditions, such as injury severity score (β: 0.67; p < 0.001) and length of hospitalization (β: 0.28; p < 0.001). Regarding access to health services, the risk of disability was higher among those who were readmitted to the health institution (β: 4.96; p < 0.001).
Conclusions: Disability caused by road traffic injuries must be conceived as a complex phenomenon to be studied, involving the non-linear interaction between the individual's deficiencies and contextual factors.
{"title":"Disability in subjects who survive road traffic injuries in 2 regions of southwest Colombia: A causal mediation analysis.","authors":"Lina Marcela Sandoval, Andrés Fandiño-Losada, Elvis Siprian Castro-Alzate, Claudio Bustos, Alberto Federico García, Adrián David Fernández","doi":"10.1016/j.cjtee.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.01.005","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of the study was to determine the causal interrelationships between sociodemography, clinic, and injury characteristics, and to access to rehabilitation services that generate disability in road traffic injury survivors in 2 regions of Southwest Colombia during the 2018-2021 period.</p><p><strong>Methods: </strong>An ambispective cohort study included 261 survivors from road traffic in 2 regions of Southwest Colombia (Cauca and Valle del Cauca) between April 19, 2021 and June 03, 2022. These survivors accepted treatment in 3 high-level comprehensive health institutions in Cali, Colombia, which are regional referral centers for trauma in the region. Patients (1) with hospitalization time ≥12 h, (2) aged ≥18 years, and (3) having the ability to understand the research questionnaires by themselves or their legal representatives, were included. Those with a history of deficiency before the road traffic injury were excluded. A structural equation model of causal pathways of disability was established to estimate exposure variables that are sociodemography, clinic, and access to rehabilitation services. The main outcome variable was disability, estimated by the World Health Organization Disability Assessment Schedule 2.0. Exposure variables related to clinical characteristics were measured through medical record review. The variables of access to rehabilitation services and disability were measured through a telephone-based survey. Structural equation analysis was performed, estimating the mediating effects of disability. The analyses were conducted in the software R Studio® y Mplus®.</p><p><strong>Results: </strong>The study found a significant gender difference in disability, with women presenting a significantly higher disability than men (β: 6.21; p = 0.041). Disability was also associated with clinical conditions, such as injury severity score (β: 0.67; p < 0.001) and length of hospitalization (β: 0.28; p < 0.001). Regarding access to health services, the risk of disability was higher among those who were readmitted to the health institution (β: 4.96; p < 0.001).</p><p><strong>Conclusions: </strong>Disability caused by road traffic injuries must be conceived as a complex phenomenon to be studied, involving the non-linear interaction between the individual's deficiencies and contextual factors.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-23DOI: 10.1016/j.cjtee.2025.02.008
Ibrahim Serag, Mohamed Abouzid, Heba Hikal, Ahmed Abdelhadi, Mohammed Nabil Abdelaal, Ahmed Gamal Mohamed, Mostafa Hossam El Din Moawad
Purpose: Anterior cruciate ligament (ACL) injuries significantly impact athletes' careers and quality of life, necessitating ACL reconstruction to restore knee functionality. Platelet-rich plasma (PRP) has been investigated as an adjunct therapy for enhancing recovery post-ACL reconstruction due to its potential pro-regenerative properties. However, the empirical evidence on PRP's efficacy in ACL reconstruction outcomes remains mixed. This study aims to evaluate the effectiveness and safety of PRP vs. control treatments in patients undergoing ACL reconstruction, focusing on pain management and knee function recovery.
Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic review and meta-analysis of randomized controlled trials comparing PRP with control interventions post-ACL reconstruction. Comprehensive searches were performed across PubMed, Scopus, Web of Science, and Cochrane Library databases up to July 2024. We used "platelet-rich plasma", "controls", and "anterior cruciate ligament reconstruction surgery" as keywords. Statistical analysis was conducted using RevMan 5.3, employing the inverse variance method under a random effects model. We reported outcomes as mean difference (MD) or standardized with confidence intervals (CI). A p < 0.05 was considered statistically significant.
Results: The analysis incorporated data from 18 studies involving 1082 patients. KT-1000 measurements indicated improved knee stability (MD: -0.57 mm, 95% CI: -0.94 to -0.20, p = 0.002). However, no significant improvements were observed in the Lysholm score (MD: 0.68, 95% CI: =1.24 to 2.26, p = 0.484), visual analog scale pain score (MD: -0.34, 95% CI: -0.68 to -0.01, p = 0.057), International Knee Documentation Committee score (MD: 1.08, 95% CI: -1.05 to 3.42, p = 0.298), Tegner score (MD: 0.13, 95% CI: -0.32 to 0.57, p = 0.575), and femoral and tibial tunnel diameters (femoral MD: -0.07 mm, 95% CI: -0.46 to 0.32, p = 0.726; tibial MD: 0.08 mm, 95% CI: -0.60 to 0.75, p = 0.818).
Conclusion: Our findings provide moderate evidence that PRP can significantly enhance knee stability post-ACL reconstruction. However, further high-quality randomized controlled trials are needed to clarify PRP's overall effectiveness and optimal use in ACL reconstruction rehabilitation protocols.
{"title":"Platelet-rich plasma in anterior cruciate ligament reconstruction: An updated systematic review and quantitative meta-analysis of randomized controlled trials.","authors":"Ibrahim Serag, Mohamed Abouzid, Heba Hikal, Ahmed Abdelhadi, Mohammed Nabil Abdelaal, Ahmed Gamal Mohamed, Mostafa Hossam El Din Moawad","doi":"10.1016/j.cjtee.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.008","url":null,"abstract":"<p><strong>Purpose: </strong>Anterior cruciate ligament (ACL) injuries significantly impact athletes' careers and quality of life, necessitating ACL reconstruction to restore knee functionality. Platelet-rich plasma (PRP) has been investigated as an adjunct therapy for enhancing recovery post-ACL reconstruction due to its potential pro-regenerative properties. However, the empirical evidence on PRP's efficacy in ACL reconstruction outcomes remains mixed. This study aims to evaluate the effectiveness and safety of PRP vs. control treatments in patients undergoing ACL reconstruction, focusing on pain management and knee function recovery.</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic review and meta-analysis of randomized controlled trials comparing PRP with control interventions post-ACL reconstruction. Comprehensive searches were performed across PubMed, Scopus, Web of Science, and Cochrane Library databases up to July 2024. We used \"platelet-rich plasma\", \"controls\", and \"anterior cruciate ligament reconstruction surgery\" as keywords. Statistical analysis was conducted using RevMan 5.3, employing the inverse variance method under a random effects model. We reported outcomes as mean difference (MD) or standardized with confidence intervals (CI). A p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>The analysis incorporated data from 18 studies involving 1082 patients. KT-1000 measurements indicated improved knee stability (MD: -0.57 mm, 95% CI: -0.94 to -0.20, p = 0.002). However, no significant improvements were observed in the Lysholm score (MD: 0.68, 95% CI: =1.24 to 2.26, p = 0.484), visual analog scale pain score (MD: -0.34, 95% CI: -0.68 to -0.01, p = 0.057), International Knee Documentation Committee score (MD: 1.08, 95% CI: -1.05 to 3.42, p = 0.298), Tegner score (MD: 0.13, 95% CI: -0.32 to 0.57, p = 0.575), and femoral and tibial tunnel diameters (femoral MD: -0.07 mm, 95% CI: -0.46 to 0.32, p = 0.726; tibial MD: 0.08 mm, 95% CI: -0.60 to 0.75, p = 0.818).</p><p><strong>Conclusion: </strong>Our findings provide moderate evidence that PRP can significantly enhance knee stability post-ACL reconstruction. However, further high-quality randomized controlled trials are needed to clarify PRP's overall effectiveness and optimal use in ACL reconstruction rehabilitation protocols.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144762271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-09DOI: 10.1016/j.cjtee.2025.02.005
Radovan Zdero, Pawel Brzozowski, Emil H Schemitsch
Purpose: Proximal fractures of the tibia (i.e., shin bone) are often treated using proximal tibia fracture plates (PTFPs) that are not always biomechanically optimal. This is a review of biomechanical papers that studied the effect of modifying PTFP plate and screw variables.
Methods: PubMed, Scopus, and Web of Science databases were searched for English-language papers published before February 2024 using the terms "biomechanics" plus "proximal or plateau" plus "tibia" plus "fracture or "plate." Eligibility criteria were applied: (1) biomechanical studies only; (2) optimization studies that systematically permutated plate or screw variables; (3) plate-and-screw fixation only; (4) intra-articular or extra-articular fractures. The papers were examined for implant variables such as plate geometry, plate material, screw number, etc., while papers were also examined for outcome metrics like interfragmentary motion, plate stress, overall stiffness, etc. RESULTS: The 52 eligible PTFP papers considered the biomechanical effect of plate geometry, material, hole type, number, and position, while screw variables included geometry, number, and angle. Outcome metrics were interfragmentary motion (0-22.53 mm or 0-60.1°), bone stress (1-1170 MPa), plate stress (3-586 MPa), and screw stress (3-1613 MPa), bone stress under the plate (2-11 MPa), number of loading cycles to failure (11,500-1,000,000), overall stiffness (22-24,869 N/mm or 0.4-63.8 Nm/degree), and failure strength (259-14,387 N). Reviewed papers showed that a PTFP's biomechanical stability could be maximized by using 1 or 2 plates that were contoured, larger, locking, metal, and/or placed on the largest surface of the bone fragment(s), while head, kickstand, and/or shaft screws should be longer, thicker, solid, metal, and/or angled. But more future work could be done on the biomechanical effect of plate design (e.g., alternative materials), bone quality (e.g., normal vs. osteoporotic), loading mode (i.e., axial, bending, torsion), etc. CONCLUSIONS: PTFPs should have their plate and screw variables optimized to provide the best biomechanical performance and clinical outcomes, but more work is required to determine the optimal conditions. Engineers and surgeons may find this review beneficial for designing, analyzing, or utilizing PTFPs.
{"title":"Biomechanical performance of proximal tibia fracture plates: A review.","authors":"Radovan Zdero, Pawel Brzozowski, Emil H Schemitsch","doi":"10.1016/j.cjtee.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.cjtee.2025.02.005","url":null,"abstract":"<p><strong>Purpose: </strong>Proximal fractures of the tibia (i.e., shin bone) are often treated using proximal tibia fracture plates (PTFPs) that are not always biomechanically optimal. This is a review of biomechanical papers that studied the effect of modifying PTFP plate and screw variables.</p><p><strong>Methods: </strong>PubMed, Scopus, and Web of Science databases were searched for English-language papers published before February 2024 using the terms \"biomechanics\" plus \"proximal or plateau\" plus \"tibia\" plus \"fracture or \"plate.\" Eligibility criteria were applied: (1) biomechanical studies only; (2) optimization studies that systematically permutated plate or screw variables; (3) plate-and-screw fixation only; (4) intra-articular or extra-articular fractures. The papers were examined for implant variables such as plate geometry, plate material, screw number, etc., while papers were also examined for outcome metrics like interfragmentary motion, plate stress, overall stiffness, etc. RESULTS: The 52 eligible PTFP papers considered the biomechanical effect of plate geometry, material, hole type, number, and position, while screw variables included geometry, number, and angle. Outcome metrics were interfragmentary motion (0-22.53 mm or 0-60.1°), bone stress (1-1170 MPa), plate stress (3-586 MPa), and screw stress (3-1613 MPa), bone stress under the plate (2-11 MPa), number of loading cycles to failure (11,500-1,000,000), overall stiffness (22-24,869 N/mm or 0.4-63.8 Nm/degree), and failure strength (259-14,387 N). Reviewed papers showed that a PTFP's biomechanical stability could be maximized by using 1 or 2 plates that were contoured, larger, locking, metal, and/or placed on the largest surface of the bone fragment(s), while head, kickstand, and/or shaft screws should be longer, thicker, solid, metal, and/or angled. But more future work could be done on the biomechanical effect of plate design (e.g., alternative materials), bone quality (e.g., normal vs. osteoporotic), loading mode (i.e., axial, bending, torsion), etc. CONCLUSIONS: PTFPs should have their plate and screw variables optimized to provide the best biomechanical performance and clinical outcomes, but more work is required to determine the optimal conditions. Engineers and surgeons may find this review beneficial for designing, analyzing, or utilizing PTFPs.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: This study aimed to evaluate the treatment of scaphoid nonunion with dual screw fixation in preventing postoperative humpback deformity.
Methods: This retrospective study is from December 2010 to December 2021, 18 patients with scaphoid nonunion were treated with dual screw fixation through the dorsal approach. This study included patients aged 16-60 years with scaphoid nonunion (>6 months) classified as Mack-Lichtman types I-III (mild arthritis), while excluding those with immature osteogenesis (<16 years), osteoporosis (>60 years), prior wrist surgery or fractures, avascular necrosis, advanced degenerative changes (types IV-V), small fragment fixation difficulty, or loss to follow-up. Scaphoid length and angles were assessed on X-rays. Wrist function was assessed based on the Mayo wrist score.
Results: The average age of the participants was 27 (range 17-49) years. The mean time from injury to surgery was 13 (range 6-48) months. There were types I (n=5), II (n=11), and III (n=2) nonunions based on the Mack-Lichtman classification. Nonunion sites included proximal 1/3 (n=4), waist (n=8), and distal 1/3 (n=6). All nonunions healed at a mean of 15 (range 10-28) weeks. The preoperative scaphoid length was 20 (range 17-23) mm, and the data at bone union was 23 (range 21-26) mm. The preoperative scapholunate angle was 46° (range 18°-72°), and the data at bone union was 39° (range 30°-48°). The preoperative radiolunate angle was 24° (range 5°-51°), and the data at bone union was 18° (range 8°-29°). Follow-up lasted for a mean of 52 (range 24-119) months. Mayo wrist score improved from 47 (range 13-64) to 95 (range 78-100). There were 15 excellent, 2 good, and 1 satisfactory results.
Conclusion: In the treatment of scaphoid nonunion, dual screw fixation through the dorsal approach can successfully prevent postoperative humpback deformity. Reduction is maintained to bone union without complications. The technique can be an alternative for the treatment of scaphoid nonunion.
{"title":"Treatment of scaphoid nonunion with dual screw fixation in preventing postoperative humpback deformity.","authors":"Jingtong Lyu, Xiao Liu, Yuanqiang Li, Zhenyu Wang, Yunjiao Wang, Wei Wang, Lin Guo","doi":"10.1016/j.cjtee.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.cjtee.2024.10.010","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the treatment of scaphoid nonunion with dual screw fixation in preventing postoperative humpback deformity.</p><p><strong>Methods: </strong>This retrospective study is from December 2010 to December 2021, 18 patients with scaphoid nonunion were treated with dual screw fixation through the dorsal approach. This study included patients aged 16-60 years with scaphoid nonunion (>6 months) classified as Mack-Lichtman types I-III (mild arthritis), while excluding those with immature osteogenesis (<16 years), osteoporosis (>60 years), prior wrist surgery or fractures, avascular necrosis, advanced degenerative changes (types IV-V), small fragment fixation difficulty, or loss to follow-up. Scaphoid length and angles were assessed on X-rays. Wrist function was assessed based on the Mayo wrist score.</p><p><strong>Results: </strong>The average age of the participants was 27 (range 17-49) years. The mean time from injury to surgery was 13 (range 6-48) months. There were types I (n=5), II (n=11), and III (n=2) nonunions based on the Mack-Lichtman classification. Nonunion sites included proximal 1/3 (n=4), waist (n=8), and distal 1/3 (n=6). All nonunions healed at a mean of 15 (range 10-28) weeks. The preoperative scaphoid length was 20 (range 17-23) mm, and the data at bone union was 23 (range 21-26) mm. The preoperative scapholunate angle was 46° (range 18°-72°), and the data at bone union was 39° (range 30°-48°). The preoperative radiolunate angle was 24° (range 5°-51°), and the data at bone union was 18° (range 8°-29°). Follow-up lasted for a mean of 52 (range 24-119) months. Mayo wrist score improved from 47 (range 13-64) to 95 (range 78-100). There were 15 excellent, 2 good, and 1 satisfactory results.</p><p><strong>Conclusion: </strong>In the treatment of scaphoid nonunion, dual screw fixation through the dorsal approach can successfully prevent postoperative humpback deformity. Reduction is maintained to bone union without complications. The technique can be an alternative for the treatment of scaphoid nonunion.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.cjtee.2024.04.007
Yan-Jun Wang , Zi-Hou Zhao , Shuai-Kun Lu , Guo-Liang Wang , Shan-Jin Ma , Lin-Hu Wang , Hao Gao , Jun Ren , Zhong-Wei An , Cong-Xiao Fu , Yong Zhang , Wen Luo , Yun-Fei Zhang
<div><h3>Purpose</h3><div>We carried out the study aiming to explore and analyze the risk factors, the distribution of pathogenic bacteria, and their antibiotic-resistance characteristics influencing the occurrence of surgical site infection (SSI), to provide valuable assistance for reducing the incidence of SSI after traumatic fracture surgery.</div></div><div><h3>Methods</h3><div>A retrospective case-control study enrolling 3978 participants from January 2015 to December 2019 receiving surgical treatment for traumatic fractures was conducted at Tangdu Hospital of Air Force Medical University. Baseline data, demographic characteristics, lifestyles, variables related to surgical treatment, and pathogen culture were harvested and analyzed. Univariate analyses and multivariate logistic regression analyses were used to reveal the independent risk factors of SSI. A bacterial distribution histogram and drug-sensitive heat map were drawn to describe the pathogenic characteristics.</div></div><div><h3>Results</h3><div>Included 3978 patients 138 of them developed SSI with an incidence rate of 3.47% postoperatively. By logistic regression analysis, we found that variables such as gender (males) (odds ratio (<em>OR</em>) = 2.012, 95% confidence interval (<em>CI</em><em>)</em>: 1.235 − 3.278, <em>p</em> = 0.005), diabetes mellitus (<em>OR</em> = 5.848, 95% <em>CI</em>: 3.513 − 9.736, <em>p</em> < 0.001), hypoproteinemia (<em>OR</em> = 3.400, 95% <em>CI</em>: 1.280 − 9.031, <em>p</em> = 0.014), underlying disease (<em>OR</em> = 5.398, 95% <em>CI</em>: 2.343 − 12.438, <em>p</em> < 0.001), hormonotherapy (<em>OR</em> = 11.718, 95% <em>CI</em>: 6.269 − 21.903, <em>p</em> < 0.001), open fracture (<em>OR</em> = 29.377, 95% <em>CI</em>: 9.944 − 86.784, <em>p</em> < 0.001), and intraoperative transfusion (<em>OR</em> = 2.664, 95% <em>CI</em>: 1.572 − 4.515, <em>p</em> < 0.001) were independent risk factors for SSI, while, aged over 59 years (<em>OR</em> = 0.132, 95% <em>CI</em>: 0.059 − 0.296, <em>p</em> < 0.001), prophylactic antibiotics use (<em>OR</em> = 0.082, 95% <em>CI</em>: 0.042 − 0.164, <em>p</em> < 0.001) and vacuum sealing drainage use (<em>OR</em> = 0.036, 95% <em>CI</em>: 0.010 − 0.129, <em>p</em> < 0.001) were protective factors. Pathogens results showed that 301 strains of 38 species of bacteria were harvested, among which 178 (59.1%) strains were Gram-positive bacteria, and 123 (40.9%) strains were Gram-negative bacteria. <em>Staphylococcus aureus</em> (108, 60.7%) and <em>Enterobacter cloacae</em> (38, 30.9%) accounted for the largest proportion. The susceptibility of Gram-positive bacteria to Vancomycin and Linezolid was almost 100%. The susceptibility of Gram-negative bacteria to Imipenem, Amikacin, and Meropenem exceeded 73%.</div></div><div><h3>Conclusion</h3><div>Orthopedic surgeons need to develop appropriate surgical plans based on the risk factors and protective factors associated with postoperative SSI to reduce its
{"title":"Analysis of risk factors, pathogenic bacteria characteristics, and drug resistance of postoperative surgical site infection in adults with limb fractures","authors":"Yan-Jun Wang , Zi-Hou Zhao , Shuai-Kun Lu , Guo-Liang Wang , Shan-Jin Ma , Lin-Hu Wang , Hao Gao , Jun Ren , Zhong-Wei An , Cong-Xiao Fu , Yong Zhang , Wen Luo , Yun-Fei Zhang","doi":"10.1016/j.cjtee.2024.04.007","DOIUrl":"10.1016/j.cjtee.2024.04.007","url":null,"abstract":"<div><h3>Purpose</h3><div>We carried out the study aiming to explore and analyze the risk factors, the distribution of pathogenic bacteria, and their antibiotic-resistance characteristics influencing the occurrence of surgical site infection (SSI), to provide valuable assistance for reducing the incidence of SSI after traumatic fracture surgery.</div></div><div><h3>Methods</h3><div>A retrospective case-control study enrolling 3978 participants from January 2015 to December 2019 receiving surgical treatment for traumatic fractures was conducted at Tangdu Hospital of Air Force Medical University. Baseline data, demographic characteristics, lifestyles, variables related to surgical treatment, and pathogen culture were harvested and analyzed. Univariate analyses and multivariate logistic regression analyses were used to reveal the independent risk factors of SSI. A bacterial distribution histogram and drug-sensitive heat map were drawn to describe the pathogenic characteristics.</div></div><div><h3>Results</h3><div>Included 3978 patients 138 of them developed SSI with an incidence rate of 3.47% postoperatively. By logistic regression analysis, we found that variables such as gender (males) (odds ratio (<em>OR</em>) = 2.012, 95% confidence interval (<em>CI</em><em>)</em>: 1.235 − 3.278, <em>p</em> = 0.005), diabetes mellitus (<em>OR</em> = 5.848, 95% <em>CI</em>: 3.513 − 9.736, <em>p</em> < 0.001), hypoproteinemia (<em>OR</em> = 3.400, 95% <em>CI</em>: 1.280 − 9.031, <em>p</em> = 0.014), underlying disease (<em>OR</em> = 5.398, 95% <em>CI</em>: 2.343 − 12.438, <em>p</em> < 0.001), hormonotherapy (<em>OR</em> = 11.718, 95% <em>CI</em>: 6.269 − 21.903, <em>p</em> < 0.001), open fracture (<em>OR</em> = 29.377, 95% <em>CI</em>: 9.944 − 86.784, <em>p</em> < 0.001), and intraoperative transfusion (<em>OR</em> = 2.664, 95% <em>CI</em>: 1.572 − 4.515, <em>p</em> < 0.001) were independent risk factors for SSI, while, aged over 59 years (<em>OR</em> = 0.132, 95% <em>CI</em>: 0.059 − 0.296, <em>p</em> < 0.001), prophylactic antibiotics use (<em>OR</em> = 0.082, 95% <em>CI</em>: 0.042 − 0.164, <em>p</em> < 0.001) and vacuum sealing drainage use (<em>OR</em> = 0.036, 95% <em>CI</em>: 0.010 − 0.129, <em>p</em> < 0.001) were protective factors. Pathogens results showed that 301 strains of 38 species of bacteria were harvested, among which 178 (59.1%) strains were Gram-positive bacteria, and 123 (40.9%) strains were Gram-negative bacteria. <em>Staphylococcus aureus</em> (108, 60.7%) and <em>Enterobacter cloacae</em> (38, 30.9%) accounted for the largest proportion. The susceptibility of Gram-positive bacteria to Vancomycin and Linezolid was almost 100%. The susceptibility of Gram-negative bacteria to Imipenem, Amikacin, and Meropenem exceeded 73%.</div></div><div><h3>Conclusion</h3><div>Orthopedic surgeons need to develop appropriate surgical plans based on the risk factors and protective factors associated with postoperative SSI to reduce its","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages 241-251"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/S1008-1275(25)00072-0
{"title":"Guide for Author","authors":"","doi":"10.1016/S1008-1275(25)00072-0","DOIUrl":"10.1016/S1008-1275(25)00072-0","url":null,"abstract":"","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"28 4","pages":"Pages I-V"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}