Introduction and Aim: Presence of virulence factors may cause increased persistence of Enterococci in the healthcare environment, increase ability to colonise inpatients and thereby result in the transmission of infection. The present study was performed to detect the presence of virulence traits among the clinical strains of Enterococci and to determine its association between virulence factors and susceptibility to various antibiotics. Materials and Methods: Clinical isolates of Enterococci were identified to species level by conventional method and Vitek 2 automated method and subjected to antibiotic susceptibility testing using disk diffusion and Minimum Inhibitory Concentration (MIC) method. Presence of hemolysin, gelatinase and biofilm was detected by phenotypic method. Results: Out of 708 isolates from urine 39 (5.51%) Enterococcus faecalis, and 3 isolates each of Enterococcus faecium (0.42 %) and Enterococcus durans (0.42 %) were biofilm producers. Beta hemolysin production was detected in 342 (48.30%) E. faecalis obtained from urine and 9/48 (18.75 %) from pus. Out of the isolates studied, 9/774 (1.16 %) isolates were found to be positive for beta-hemolysin production, gelatinase and biofilm production. All the 9 (100.00 %) isolates were resistant to penicillin, high level gentamicin, ciprofloxacin and levofloxacin. Conclusion: Virulence factors described in Enterococci enable these organisms to colonise patient tissue, increase resistance to antimicrobial agents and aggravate infection outcome.
{"title":"A study on virulence determinants and antimicrobial resistance among Enterococci isolates","authors":"Reena Rajan, K. Dhandapani","doi":"10.51248/.v43i3.1160","DOIUrl":"https://doi.org/10.51248/.v43i3.1160","url":null,"abstract":"Introduction and Aim: Presence of virulence factors may cause increased persistence of Enterococci in the healthcare environment, increase ability to colonise inpatients and thereby result in the transmission of infection. The present study was performed to detect the presence of virulence traits among the clinical strains of Enterococci and to determine its association between virulence factors and susceptibility to various antibiotics.\u0000 \u0000Materials and Methods: Clinical isolates of Enterococci were identified to species level by conventional method and Vitek 2 automated method and subjected to antibiotic susceptibility testing using disk diffusion and Minimum Inhibitory Concentration (MIC) method. Presence of hemolysin, gelatinase and biofilm was detected by phenotypic method.\u0000 \u0000Results: Out of 708 isolates from urine 39 (5.51%) Enterococcus faecalis, and 3 isolates each of Enterococcus faecium (0.42 %) and Enterococcus durans (0.42 %) were biofilm producers. Beta hemolysin production was detected in 342 (48.30%) E. faecalis obtained from urine and 9/48 (18.75 %) from pus. Out of the isolates studied, 9/774 (1.16 %) isolates were found to be positive for beta-hemolysin production, gelatinase and biofilm production. All the 9 (100.00 %) isolates were resistant to penicillin, high level gentamicin, ciprofloxacin and levofloxacin.\u0000 \u0000Conclusion: Virulence factors described in Enterococci enable these organisms to colonise patient tissue, increase resistance to antimicrobial agents and aggravate infection outcome.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48602113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sathya Siva, Madhanraj Sekar, Surya Prakash V., Titus J., Mohammed Arifullah Mohamed Fazulah, S. V
Protease enzymes found in the Indian papaya, also called Carica papaya, are known to have de-sloughing and wound healing properties. It was found that Carica papaya applied to a lesion enhanced phagocytic cell killing of bacteria. Green papaya is rich in papain and chymopapain, two potent digestive enzymes that can break down dead tissue and have anti-inflammatory properties. To compare the effectiveness of conventional and Carica papaya management in wound healing the systematic review and meta-analysis is conducted. Based on PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, a systematic review is conducted. While using the search terms ‘Diabetic foot ulcer, conventional management, wound healing, Carica papaya’ in the MEDLINE, Google Scholar, and PubMed databases. Carica papaya has a good beneficial effect on reducing necrosis and is frequently utilized in the management of wound healing. None of the studies have demonstrated any adverse impacts of Carica papaya on wound healing.
{"title":"Effectiveness of conventional management and Carica papaya on influencing wound healing: A systematic review and meta-analysis","authors":"Sathya Siva, Madhanraj Sekar, Surya Prakash V., Titus J., Mohammed Arifullah Mohamed Fazulah, S. V","doi":"10.51248/.v43i3.2851","DOIUrl":"https://doi.org/10.51248/.v43i3.2851","url":null,"abstract":"Protease enzymes found in the Indian papaya, also called Carica papaya, are known to have de-sloughing and wound healing properties. It was found that Carica papaya applied to a lesion enhanced phagocytic cell killing of bacteria. Green papaya is rich in papain and chymopapain, two potent digestive enzymes that can break down dead tissue and have anti-inflammatory properties. To compare the effectiveness of conventional and Carica papaya management in wound healing the systematic review and meta-analysis is conducted. Based on PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, a systematic review is conducted. While using the search terms ‘Diabetic foot ulcer, conventional management, wound healing, Carica papaya’ in the MEDLINE, Google Scholar, and PubMed databases. Carica papaya has a good beneficial effect on reducing necrosis and is frequently utilized in the management of wound healing. None of the studies have demonstrated any adverse impacts of Carica papaya on wound healing.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46613814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shilpa Dutta, Akash More, Priti Karadbhajne, D. Shrivastava
Platelet-rich plasma therapy, also truncated as PRP, has been remarkably utilized for quite long in the domains of cardiovascular surgery, orthopaedic treatments, sports medicines etc. Being in the limelight for its remarkable wound healing and cell proliferating activities, it has caught the interest of researchers in the field of reproductive sciences. The chief domain of research has revolved around thin endometrial lining, diminished ovarian content, recurrent implantation failure ailments etc. This article has focused on reviewing existing articles till now on the aetiology of PRP along with methodologies and results in reproductive aberrational conditions. Restrictive research is conducted from Scopus and Web of Science indexed journals, PubMed focusing on the deployment of PRP in infertility science and categorized the result under 3 genres: PRP in refractory attenuated endometrium, PRP in female gonadal abnormalities and PRP in Asherman’s syndrome. Most literature has shown promising results in improvement of thin endometrium, along with increase in AMH (Anti-Mullerian Hormone) level along with decrement of FSH (Follicle Stimulating Hormone) level, thereby improving ovarian reserve. It also showed reduced adhesion in the uterus after hysteroscopy, along with improvement in the menstrual cycle in case of Asherman’s syndrome, thereby increasing chances of clinical pregnancy. However, lack of standardized protocol is a major con in variation of results. Thus, until conclusive RCTs with larger sample size are conducted, PRP should be restricted to the experimental stage for now.
富含血小板的血浆疗法，也称为PRP，长期以来一直在心血管外科、整形外科、运动医学等领域得到显著应用。由于其显著的伤口愈合和细胞增殖活性而备受关注，它引起了生殖科学领域研究人员的兴趣。主要研究领域围绕着子宫内膜薄、卵巢内容物减少、复发性植入失败疾病等。本文重点回顾了迄今为止关于PRP病因的现有文章，以及生殖异常条件下的方法和结果。Scopus和Web of Science索引期刊PubMed进行了限制性研究，重点关注PRP在不孕科学中的应用，并将结果分为三类：难治性减薄子宫内膜中的PRP、女性性腺异常中的PRP-和Asherman综合征中的PRP。大多数文献显示，在改善薄子宫内膜、提高AMH（抗苗勒管激素）水平和降低FSH（卵泡刺激激素）水平方面取得了有希望的结果，从而改善卵巢储备。宫腔镜检查后，子宫粘连减少，Asherman综合征患者月经周期改善，从而增加了临床妊娠的机会。然而，缺乏标准化的方案是导致结果变化的主要因素。因此，在进行更大样本量的决定性随机对照试验之前，PRP目前应限制在实验阶段。
{"title":"Contribution of platelet-rich plasma therapy in reproductive health science: A narrative review","authors":"Shilpa Dutta, Akash More, Priti Karadbhajne, D. Shrivastava","doi":"10.51248/.v43i3.2678","DOIUrl":"https://doi.org/10.51248/.v43i3.2678","url":null,"abstract":"Platelet-rich plasma therapy, also truncated as PRP, has been remarkably utilized for quite long in the domains of cardiovascular surgery, orthopaedic treatments, sports medicines etc. Being in the limelight for its remarkable wound healing and cell proliferating activities, it has caught the interest of researchers in the field of reproductive sciences. The chief domain of research has revolved around thin endometrial lining, diminished ovarian content, recurrent implantation failure ailments etc. This article has focused on reviewing existing articles till now on the aetiology of PRP along with methodologies and results in reproductive aberrational conditions. Restrictive research is conducted from Scopus and Web of Science indexed journals, PubMed focusing on the deployment of PRP in infertility science and categorized the result under 3 genres: PRP in refractory attenuated endometrium, PRP in female gonadal abnormalities and PRP in Asherman’s syndrome. Most literature has shown promising results in improvement of thin endometrium, along with increase in AMH (Anti-Mullerian Hormone) level along with decrement of FSH (Follicle Stimulating Hormone) level, thereby improving ovarian reserve. It also showed reduced adhesion in the uterus after hysteroscopy, along with improvement in the menstrual cycle in case of Asherman’s syndrome, thereby increasing chances of clinical pregnancy. However, lack of standardized protocol is a major con in variation of results. Thus, until conclusive RCTs with larger sample size are conducted, PRP should be restricted to the experimental stage for now.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45501343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh
Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects. Materials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis. Results: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here. Conclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.
{"title":"Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment","authors":"Hardi Kapadia, Divya Vora, Dinesh S. Manjegowda, A. Nair, Sameer Sharma, Susha Dinesh","doi":"10.51248/.v43i3.2867","DOIUrl":"https://doi.org/10.51248/.v43i3.2867","url":null,"abstract":"Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.\u0000 \u0000Materials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.\u0000 \u0000Results: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.\u0000 \u0000Conclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42991282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Abdyldaev, Banur Uzakbaeva, B. Bebezov, Iana Karabaeva, Zhanna Abdyldaeva, T. Tagaev
Introduction and Aim: Breast infections are an increasing problem for women who are breastfeeding, with symptoms ranging from mastitis to the development of abscesses. The aim of this study is to develop a minimally invasive method of interventional continuous vacuum drainage for the treatment of lactational purulent mastitis. Materials and Methods: All 53 patients were comparable based on the duration of the disease prior to surgery and the timing of the emergence of mastitis after delivery, as well as the location and prevalence of the inflammatory process in the mammary gland. Results: During the single-catheter method of vacuum drainage for the treatment of lactational purulent mastitis, lactation of the patient's affected breast was good in 2 (4.2%) patients and satisfactory in 46 (95.8%) patients. 38 (792%) women had good lactation, whereas 10 (21.8%) women had adequate lactation. After using the single-catheter method of vacuum drainage to treat lactational purulent mastitis, good lactation was seen in 40 (83.3%) instances, and it was satisfactory in 8 (16.7%) of patients. Conclusion: A single-catheter interventional continuous vacuum drainage under ultrasound control was developed to treat lactational purulent mastitis without antibacterial therapy in 5–7 days, preserving lactation and achieving good aesthetic results.
{"title":"Single-catheter minimally invasive method of interventional continuous vacuum drainage for the treatment of lactational purulent mastitis","authors":"D. Abdyldaev, Banur Uzakbaeva, B. Bebezov, Iana Karabaeva, Zhanna Abdyldaeva, T. Tagaev","doi":"10.51248/.v43i3.2883","DOIUrl":"https://doi.org/10.51248/.v43i3.2883","url":null,"abstract":"Introduction and Aim: Breast infections are an increasing problem for women who are breastfeeding, with symptoms ranging from mastitis to the development of abscesses. The aim of this study is to develop a minimally invasive method of interventional continuous vacuum drainage for the treatment of lactational purulent mastitis.\u0000 \u0000Materials and Methods: All 53 patients were comparable based on the duration of the disease prior to surgery and the timing of the emergence of mastitis after delivery, as well as the location and prevalence of the inflammatory process in the mammary gland.\u0000 \u0000Results: During the single-catheter method of vacuum drainage for the treatment of lactational purulent mastitis, lactation of the patient's affected breast was good in 2 (4.2%) patients and satisfactory in 46 (95.8%) patients. 38 (792%) women had good lactation, whereas 10 (21.8%) women had adequate lactation. After using the single-catheter method of vacuum drainage to treat lactational purulent mastitis, good lactation was seen in 40 (83.3%) instances, and it was satisfactory in 8 (16.7%) of patients.\u0000 \u0000Conclusion: A single-catheter interventional continuous vacuum drainage under ultrasound control was developed to treat lactational purulent mastitis without antibacterial therapy in 5–7 days, preserving lactation and achieving good aesthetic results.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49362959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Praveena Ravichandran, K. Bhat, M. Hosapatna, P. L. C.
Introduction and Aim: The Circle of Willis (CoW) is an arterial hexagon in the interpeduncular fossa formed by the basilar and internal carotid arteries. It permits anastomotic circulation between that two-arterial system. Variations in the pattern and the calibre of the arteries that make up the CoW were common. Few noted variations include hypoplasia or aplasia of either one or both posterior or anterior communicating arteries, aplasia, or fenestrations of the anterior communicating artery. Considering the surgical importance of this arterial circle, as it allows equalization of blood flow between the two sides of the brain, this observational study was done to identify the variations in the formation pattern and the gross morphometry of CoW. Materials and Methods: Thirty radiological images of patients undergoing neurovascular imaging for various reasons in the Department of Radiology and patients were obtained for the study. Results: Among the 30 studied CT and MR angiographic images, 21 (73.3%) of the circles exhibit the usual pattern of CoW formation, and the remaining 9 (27.7%) showed variations. Among the 30 radiological images, 25 (83.33%) were complete circles, 4 (13.33%) were incomplete in the posterior part and 1 (3.33%) was incomplete in the anterior part of the CoW. Conclusion: Understanding the typical formation of CoW and its variations is essential in the surgical correction of a few intracranial emergencies like hemorrhage, infarction, aneurysms, and other neurovascular surgeries of the brain.
{"title":"Radiological observations of the branches of circle of willis for surgical perception","authors":"Praveena Ravichandran, K. Bhat, M. Hosapatna, P. L. C.","doi":"10.51248/.v43i3.2557","DOIUrl":"https://doi.org/10.51248/.v43i3.2557","url":null,"abstract":"Introduction and Aim: The Circle of Willis (CoW) is an arterial hexagon in the interpeduncular fossa formed by the basilar and internal carotid arteries. It permits anastomotic circulation between that two-arterial system. Variations in the pattern and the calibre of the arteries that make up the CoW were common. Few noted variations include hypoplasia or aplasia of either one or both posterior or anterior communicating arteries, aplasia, or fenestrations of the anterior communicating artery. Considering the surgical importance of this arterial circle, as it allows equalization of blood flow between the two sides of the brain, this observational study was done to identify the variations in the formation pattern and the gross morphometry of CoW.\u0000 \u0000Materials and Methods: Thirty radiological images of patients undergoing neurovascular imaging for various reasons in the Department of Radiology and patients were obtained for the study.\u0000 \u0000Results: Among the 30 studied CT and MR angiographic images, 21 (73.3%) of the circles exhibit the usual pattern of CoW formation, and the remaining 9 (27.7%) showed variations. Among the 30 radiological images, 25 (83.33%) were complete circles, 4 (13.33%) were incomplete in the posterior part and 1 (3.33%) was incomplete in the anterior part of the CoW.\u0000 \u0000Conclusion: Understanding the typical formation of CoW and its variations is essential in the surgical correction of a few intracranial emergencies like hemorrhage, infarction, aneurysms, and other neurovascular surgeries of the brain.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48129924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramana K., K. A, P. Suganthirababu, Surya Vishnuram, D. S, J. Alagesan
Introduction and Aim: Low back muscle endurance is becoming a major issue because of low back ache. Though many treatment protocols have been suggested and proved effective, endurance exercises have been under less researched area over its effectiveness in comparison to other treatment protocols. The purpose of this study is to determine the effect of trunk extensor muscle endurance training with conventional spinal exercise for trunk extensor muscle in subjects with LBP. Materials and Methods: This is a quasi-experimental study involving 56 patients in the age group of 25-35 years who were allocated in the experimental group (endurance exercises) and control group (conventional spinal exercise) for 3 times per week, for 6 weeks for a duration of 30-45 minutes. Outcome measures used for the study were McGill Pain Questionnaire, RMDQ, 60 sec. spinal extension endurance tests. Results: There was no significant difference found within group analysis in all outcome measures. In between, the group analysis experimental group has shown statistically significant difference in all outcome measures at post-test with the p-value of 0.000. Conclusion: Endurance training has proved to be a much more effective method and provides faster recovery than conventional spinal extension exercise in treatment of patients with subacute low back pain.
{"title":"Effect of trunk muscle endurance training in pain management and function in sub-acute low back pain – A quasi experimental study","authors":"Ramana K., K. A, P. Suganthirababu, Surya Vishnuram, D. S, J. Alagesan","doi":"10.51248/.v43i3.404","DOIUrl":"https://doi.org/10.51248/.v43i3.404","url":null,"abstract":"Introduction and Aim: Low back muscle endurance is becoming a major issue because of low back ache. Though many treatment protocols have been suggested and proved effective, endurance exercises have been under less researched area over its effectiveness in comparison to other treatment protocols. The purpose of this study is to determine the effect of trunk extensor muscle endurance training with conventional spinal exercise for trunk extensor muscle in subjects with LBP.\u0000 \u0000Materials and Methods: This is a quasi-experimental study involving 56 patients in the age group of 25-35 years who were allocated in the experimental group (endurance exercises) and control group (conventional spinal exercise) for 3 times per week, for 6 weeks for a duration of 30-45 minutes. Outcome measures used for the study were McGill Pain Questionnaire, RMDQ, 60 sec. spinal extension endurance tests.\u0000 \u0000Results: There was no significant difference found within group analysis in all outcome measures. In between, the group analysis experimental group has shown statistically significant difference in all outcome measures at post-test with the p-value of 0.000.\u0000 \u0000Conclusion: Endurance training has proved to be a much more effective method and provides faster recovery than conventional spinal extension exercise in treatment of patients with subacute low back pain.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44870769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Yrysov, N. Arstanbekov, M. Mamytov, Akylbek Akmataliev, Bakytbek Turganbaev, Yethindra Vityala
Introduction and Aim: A benign tumor of the central nervous system known as a meningioma of the brain can be effectively treated surgically to assure complete patient recovery. The objective of this study was to investigate intracranial postoperative complications in meningiomas, identify factors that are prognostically significant, assess the results of surgical therapy, and provide rational solutions for difficulties associated with brain meningiomas. Materials and Methods: The 202 observations of patients with supratentorial meningiomas who had surgery provided the basis for the current study. In the 20 patients who survived, we looked at a number of surgical problems. Clinical evaluation and instrumental diagnostic methods were used to confirm their nature. Results: Most patients with basal located meningiomas experience surgical issues. Meningiomas were discovered to be basal in 12 (60.0%) of the survivors who encountered postoperative complications. Patients with postoperative complications from meningiomas frequently encountered many cumulative issues, with a death rate of 5 (2.5%) and one or occasionally two complications in survivors. Conclusion: The growth of tumors, surgical trauma, and the body's general reaction to the removal of neoplasms all affect the body's activity at all levels (subcellular, cellular, organ, and systemic) in patients with supratentorial meningiomas, leading to postoperative complications.
{"title":"Postoperative complications in patients with intracranial meningiomas who underwent surgery","authors":"K. Yrysov, N. Arstanbekov, M. Mamytov, Akylbek Akmataliev, Bakytbek Turganbaev, Yethindra Vityala","doi":"10.51248/.v43i3.2886","DOIUrl":"https://doi.org/10.51248/.v43i3.2886","url":null,"abstract":"Introduction and Aim: A benign tumor of the central nervous system known as a meningioma of the brain can be effectively treated surgically to assure complete patient recovery. The objective of this study was to investigate intracranial postoperative complications in meningiomas, identify factors that are prognostically significant, assess the results of surgical therapy, and provide rational solutions for difficulties associated with brain meningiomas.\u0000 \u0000Materials and Methods: The 202 observations of patients with supratentorial meningiomas who had surgery provided the basis for the current study. In the 20 patients who survived, we looked at a number of surgical problems. Clinical evaluation and instrumental diagnostic methods were used to confirm their nature.\u0000 \u0000Results: Most patients with basal located meningiomas experience surgical issues. Meningiomas were discovered to be basal in 12 (60.0%) of the survivors who encountered postoperative complications. Patients with postoperative complications from meningiomas frequently encountered many cumulative issues, with a death rate of 5 (2.5%) and one or occasionally two complications in survivors.\u0000 \u0000Conclusion: The growth of tumors, surgical trauma, and the body's general reaction to the removal of neoplasms all affect the body's activity at all levels (subcellular, cellular, organ, and systemic) in patients with supratentorial meningiomas, leading to postoperative complications.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44077126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janani Maheshwari V. Vyas, S. Kumar S., Leena Dennis Joseph, K. P, S. R
Introduction and Aim: Various herbs have been prescribed as a cure for renal disorders by early literature. Nephroprotective herbs are protective against nephrotoxicity. Tinospora cordifolia is known for its role in treating diabetes and disorders of the kidney and metabolism. However, studying its protective effect on drug induced nephrotoxicity at different time periods is wanting. The aim is to study the nephroprotective effect of Tinospora cordifolia on drug induced nephrotoxic changes upon co-administration of the herb with nephrotoxicity induction by the drug. Materials and Methods: Ethanolic extract of the stem of Tinospora cordifolia was prepared and evaluated for phytochemical constituents. Gentamicin induced nephrotoxicity model in adult, male, Wistar rats was utilised for the study. Gentamicin and the extract of Tinospora cordifolia were co-administered for 8 days. In the kidney, levels of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were measured. Assessment of the renal tissue was carried out using histopathological severity grading. Results: Phytochemicals like glycosides, flavonoids, saponins, steroids, quinone and coumarin were present in the stem of Tinospora cordifolia. Analysing the levels of oxidative stress and antioxidants in the kidney revealed the rise in the level of reduced glutathione (GSH). This correlated with the regenerative changes brought about by the herbal extract on the acute tubular necrosis in the renal tissue induced due to gentamicin nephrotoxicity, at the histological levels in terms of the reduction of enlargement and regeneration of the tubular epithelium. Conclusion: Tinospora cordifolia extract constituted flavonoids which are known antioxidants. Co-administration of Tinospora cordifolia stem extract is protective in the nephrotoxic condition induced by drugs, hence, shall benefit the kidney when taken along while consuming potentially nephrotoxic drugs.
{"title":"Co-administration with Tinospora cordifolia attenuates drug induced nephrotoxicity – A histological and biochemical assessment","authors":"Janani Maheshwari V. Vyas, S. Kumar S., Leena Dennis Joseph, K. P, S. R","doi":"10.51248/.v43i3.1698","DOIUrl":"https://doi.org/10.51248/.v43i3.1698","url":null,"abstract":"Introduction and Aim: Various herbs have been prescribed as a cure for renal disorders by early literature. Nephroprotective herbs are protective against nephrotoxicity. Tinospora cordifolia is known for its role in treating diabetes and disorders of the kidney and metabolism. However, studying its protective effect on drug induced nephrotoxicity at different time periods is wanting. The aim is to study the nephroprotective effect of Tinospora cordifolia on drug induced nephrotoxic changes upon co-administration of the herb with nephrotoxicity induction by the drug.\u0000 \u0000Materials and Methods: Ethanolic extract of the stem of Tinospora cordifolia was prepared and evaluated for phytochemical constituents. Gentamicin induced nephrotoxicity model in adult, male, Wistar rats was utilised for the study. Gentamicin and the extract of Tinospora cordifolia were co-administered for 8 days. In the kidney, levels of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were measured. Assessment of the renal tissue was carried out using histopathological severity grading.\u0000 \u0000Results: Phytochemicals like glycosides, flavonoids, saponins, steroids, quinone and coumarin were present in the stem of Tinospora cordifolia. Analysing the levels of oxidative stress and antioxidants in the kidney revealed the rise in the level of reduced glutathione (GSH). This correlated with the regenerative changes brought about by the herbal extract on the acute tubular necrosis in the renal tissue induced due to gentamicin nephrotoxicity, at the histological levels in terms of the reduction of enlargement and regeneration of the tubular epithelium.\u0000 \u0000Conclusion: Tinospora cordifolia extract constituted flavonoids which are known antioxidants. Co-administration of Tinospora cordifolia stem extract is protective in the nephrotoxic condition induced by drugs, hence, shall benefit the kidney when taken along while consuming potentially nephrotoxic drugs.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42560329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nishanthi Raja, A. Ganesan, Swathi K. V., K. A, Krithika Chandrasekar Lakshmi
Introduction and Aim: Prebiotics and probiotics are essential for improving overall health. Pre- and probiotics are becoming more popular in oral care products. Also, in recent years, oral medicine has been provided to them. The study's objective is to assess dental postgraduates' attitudes, knowledge, and awareness of prebiotics and probiotics for oral lesions. Materials and Methods: A set of 20 questions related to the definition, mechanism of action, safety consideration, health benefits, and sources, and four questions to assess their attitude and practice about probiotics and prebiotics in oral lesions addressing a total number of 183 dental postgraduates were selected. Google form questionnaires were shared, and responses were received. The obtained data were statistically analyzed. Results: Of the 183 dental postgraduates 91.3% of the dental postgraduates were aware of the use of probiotics and prebiotics in oral lesions while 92.2% were willing to prescribe them to their patients and consider them to be safe and used as an adjuvant in the management of oral lesions. Results showed limited knowledge and awareness of probiotics and prebiotics in the management of oral lesions among dental postgraduates. Conclusion: The result indicated a lack of understanding of prebiotics and probiotics in the treatment of oral lesions. It is possible to increase knowledge of prebiotics and probiotics in oral lesions through seminars, current lectures, and including the subject in the curricula of aspiring professionals, among other methods.
{"title":"Awareness of prebiotics and probiotics in oral lesions among dental postgraduates -A questionnaire-based study","authors":"Nishanthi Raja, A. Ganesan, Swathi K. V., K. A, Krithika Chandrasekar Lakshmi","doi":"10.51248/.v43i3.2716","DOIUrl":"https://doi.org/10.51248/.v43i3.2716","url":null,"abstract":"Introduction and Aim: Prebiotics and probiotics are essential for improving overall health. Pre- and probiotics are becoming more popular in oral care products. Also, in recent years, oral medicine has been provided to them. The study's objective is to assess dental postgraduates' attitudes, knowledge, and awareness of prebiotics and probiotics for oral lesions.\u0000 \u0000Materials and Methods: A set of 20 questions related to the definition, mechanism of action, safety consideration, health benefits, and sources, and four questions to assess their attitude and practice about probiotics and prebiotics in oral lesions addressing a total number of 183 dental postgraduates were selected. Google form questionnaires were shared, and responses were received. The obtained data were statistically analyzed.\u0000 \u0000Results: Of the 183 dental postgraduates 91.3% of the dental postgraduates were aware of the use of probiotics and prebiotics in oral lesions while 92.2% were willing to prescribe them to their patients and consider them to be safe and used as an adjuvant in the management of oral lesions. Results showed limited knowledge and awareness of probiotics and prebiotics in the management of oral lesions among dental postgraduates.\u0000 \u0000Conclusion: The result indicated a lack of understanding of prebiotics and probiotics in the treatment of oral lesions. It is possible to increase knowledge of prebiotics and probiotics in oral lesions through seminars, current lectures, and including the subject in the curricula of aspiring professionals, among other methods.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42525722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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