D. Abdyldaev, Banur Uzakbaeva, B. Bebezov, Iana Karabaeva, Zhanna Abdyldaeva, T. Tagaev
Introduction and Aim: Breast infections are an increasing problem for women who are breastfeeding, with symptoms ranging from mastitis to the development of abscesses. The aim of this study is to develop a minimally invasive method of interventional continuous vacuum drainage for the treatment of lactational purulent mastitis. Materials and Methods: All 53 patients were comparable based on the duration of the disease prior to surgery and the timing of the emergence of mastitis after delivery, as well as the location and prevalence of the inflammatory process in the mammary gland. Results: During the single-catheter method of vacuum drainage for the treatment of lactational purulent mastitis, lactation of the patient's affected breast was good in 2 (4.2%) patients and satisfactory in 46 (95.8%) patients. 38 (792%) women had good lactation, whereas 10 (21.8%) women had adequate lactation. After using the single-catheter method of vacuum drainage to treat lactational purulent mastitis, good lactation was seen in 40 (83.3%) instances, and it was satisfactory in 8 (16.7%) of patients. Conclusion: A single-catheter interventional continuous vacuum drainage under ultrasound control was developed to treat lactational purulent mastitis without antibacterial therapy in 5–7 days, preserving lactation and achieving good aesthetic results.
{"title":"Single-catheter minimally invasive method of interventional continuous vacuum drainage for the treatment of lactational purulent mastitis","authors":"D. Abdyldaev, Banur Uzakbaeva, B. Bebezov, Iana Karabaeva, Zhanna Abdyldaeva, T. Tagaev","doi":"10.51248/.v43i3.2883","DOIUrl":"https://doi.org/10.51248/.v43i3.2883","url":null,"abstract":"Introduction and Aim: Breast infections are an increasing problem for women who are breastfeeding, with symptoms ranging from mastitis to the development of abscesses. The aim of this study is to develop a minimally invasive method of interventional continuous vacuum drainage for the treatment of lactational purulent mastitis.\u0000 \u0000Materials and Methods: All 53 patients were comparable based on the duration of the disease prior to surgery and the timing of the emergence of mastitis after delivery, as well as the location and prevalence of the inflammatory process in the mammary gland.\u0000 \u0000Results: During the single-catheter method of vacuum drainage for the treatment of lactational purulent mastitis, lactation of the patient's affected breast was good in 2 (4.2%) patients and satisfactory in 46 (95.8%) patients. 38 (792%) women had good lactation, whereas 10 (21.8%) women had adequate lactation. After using the single-catheter method of vacuum drainage to treat lactational purulent mastitis, good lactation was seen in 40 (83.3%) instances, and it was satisfactory in 8 (16.7%) of patients.\u0000 \u0000Conclusion: A single-catheter interventional continuous vacuum drainage under ultrasound control was developed to treat lactational purulent mastitis without antibacterial therapy in 5–7 days, preserving lactation and achieving good aesthetic results.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49362959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Praveena Ravichandran, K. Bhat, M. Hosapatna, P. L. C.
Introduction and Aim: The Circle of Willis (CoW) is an arterial hexagon in the interpeduncular fossa formed by the basilar and internal carotid arteries. It permits anastomotic circulation between that two-arterial system. Variations in the pattern and the calibre of the arteries that make up the CoW were common. Few noted variations include hypoplasia or aplasia of either one or both posterior or anterior communicating arteries, aplasia, or fenestrations of the anterior communicating artery. Considering the surgical importance of this arterial circle, as it allows equalization of blood flow between the two sides of the brain, this observational study was done to identify the variations in the formation pattern and the gross morphometry of CoW. Materials and Methods: Thirty radiological images of patients undergoing neurovascular imaging for various reasons in the Department of Radiology and patients were obtained for the study. Results: Among the 30 studied CT and MR angiographic images, 21 (73.3%) of the circles exhibit the usual pattern of CoW formation, and the remaining 9 (27.7%) showed variations. Among the 30 radiological images, 25 (83.33%) were complete circles, 4 (13.33%) were incomplete in the posterior part and 1 (3.33%) was incomplete in the anterior part of the CoW. Conclusion: Understanding the typical formation of CoW and its variations is essential in the surgical correction of a few intracranial emergencies like hemorrhage, infarction, aneurysms, and other neurovascular surgeries of the brain.
{"title":"Radiological observations of the branches of circle of willis for surgical perception","authors":"Praveena Ravichandran, K. Bhat, M. Hosapatna, P. L. C.","doi":"10.51248/.v43i3.2557","DOIUrl":"https://doi.org/10.51248/.v43i3.2557","url":null,"abstract":"Introduction and Aim: The Circle of Willis (CoW) is an arterial hexagon in the interpeduncular fossa formed by the basilar and internal carotid arteries. It permits anastomotic circulation between that two-arterial system. Variations in the pattern and the calibre of the arteries that make up the CoW were common. Few noted variations include hypoplasia or aplasia of either one or both posterior or anterior communicating arteries, aplasia, or fenestrations of the anterior communicating artery. Considering the surgical importance of this arterial circle, as it allows equalization of blood flow between the two sides of the brain, this observational study was done to identify the variations in the formation pattern and the gross morphometry of CoW.\u0000 \u0000Materials and Methods: Thirty radiological images of patients undergoing neurovascular imaging for various reasons in the Department of Radiology and patients were obtained for the study.\u0000 \u0000Results: Among the 30 studied CT and MR angiographic images, 21 (73.3%) of the circles exhibit the usual pattern of CoW formation, and the remaining 9 (27.7%) showed variations. Among the 30 radiological images, 25 (83.33%) were complete circles, 4 (13.33%) were incomplete in the posterior part and 1 (3.33%) was incomplete in the anterior part of the CoW.\u0000 \u0000Conclusion: Understanding the typical formation of CoW and its variations is essential in the surgical correction of a few intracranial emergencies like hemorrhage, infarction, aneurysms, and other neurovascular surgeries of the brain.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48129924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nishanthi Raja, A. Ganesan, Swathi K. V., K. A, Krithika Chandrasekar Lakshmi
Introduction and Aim: Prebiotics and probiotics are essential for improving overall health. Pre- and probiotics are becoming more popular in oral care products. Also, in recent years, oral medicine has been provided to them. The study's objective is to assess dental postgraduates' attitudes, knowledge, and awareness of prebiotics and probiotics for oral lesions. Materials and Methods: A set of 20 questions related to the definition, mechanism of action, safety consideration, health benefits, and sources, and four questions to assess their attitude and practice about probiotics and prebiotics in oral lesions addressing a total number of 183 dental postgraduates were selected. Google form questionnaires were shared, and responses were received. The obtained data were statistically analyzed. Results: Of the 183 dental postgraduates 91.3% of the dental postgraduates were aware of the use of probiotics and prebiotics in oral lesions while 92.2% were willing to prescribe them to their patients and consider them to be safe and used as an adjuvant in the management of oral lesions. Results showed limited knowledge and awareness of probiotics and prebiotics in the management of oral lesions among dental postgraduates. Conclusion: The result indicated a lack of understanding of prebiotics and probiotics in the treatment of oral lesions. It is possible to increase knowledge of prebiotics and probiotics in oral lesions through seminars, current lectures, and including the subject in the curricula of aspiring professionals, among other methods.
{"title":"Awareness of prebiotics and probiotics in oral lesions among dental postgraduates -A questionnaire-based study","authors":"Nishanthi Raja, A. Ganesan, Swathi K. V., K. A, Krithika Chandrasekar Lakshmi","doi":"10.51248/.v43i3.2716","DOIUrl":"https://doi.org/10.51248/.v43i3.2716","url":null,"abstract":"Introduction and Aim: Prebiotics and probiotics are essential for improving overall health. Pre- and probiotics are becoming more popular in oral care products. Also, in recent years, oral medicine has been provided to them. The study's objective is to assess dental postgraduates' attitudes, knowledge, and awareness of prebiotics and probiotics for oral lesions.\u0000 \u0000Materials and Methods: A set of 20 questions related to the definition, mechanism of action, safety consideration, health benefits, and sources, and four questions to assess their attitude and practice about probiotics and prebiotics in oral lesions addressing a total number of 183 dental postgraduates were selected. Google form questionnaires were shared, and responses were received. The obtained data were statistically analyzed.\u0000 \u0000Results: Of the 183 dental postgraduates 91.3% of the dental postgraduates were aware of the use of probiotics and prebiotics in oral lesions while 92.2% were willing to prescribe them to their patients and consider them to be safe and used as an adjuvant in the management of oral lesions. Results showed limited knowledge and awareness of probiotics and prebiotics in the management of oral lesions among dental postgraduates.\u0000 \u0000Conclusion: The result indicated a lack of understanding of prebiotics and probiotics in the treatment of oral lesions. It is possible to increase knowledge of prebiotics and probiotics in oral lesions through seminars, current lectures, and including the subject in the curricula of aspiring professionals, among other methods.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42525722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Janani Maheshwari V. Vyas, S. Kumar S., Leena Dennis Joseph, K. P, S. R
Introduction and Aim: Various herbs have been prescribed as a cure for renal disorders by early literature. Nephroprotective herbs are protective against nephrotoxicity. Tinospora cordifolia is known for its role in treating diabetes and disorders of the kidney and metabolism. However, studying its protective effect on drug induced nephrotoxicity at different time periods is wanting. The aim is to study the nephroprotective effect of Tinospora cordifolia on drug induced nephrotoxic changes upon co-administration of the herb with nephrotoxicity induction by the drug. Materials and Methods: Ethanolic extract of the stem of Tinospora cordifolia was prepared and evaluated for phytochemical constituents. Gentamicin induced nephrotoxicity model in adult, male, Wistar rats was utilised for the study. Gentamicin and the extract of Tinospora cordifolia were co-administered for 8 days. In the kidney, levels of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were measured. Assessment of the renal tissue was carried out using histopathological severity grading. Results: Phytochemicals like glycosides, flavonoids, saponins, steroids, quinone and coumarin were present in the stem of Tinospora cordifolia. Analysing the levels of oxidative stress and antioxidants in the kidney revealed the rise in the level of reduced glutathione (GSH). This correlated with the regenerative changes brought about by the herbal extract on the acute tubular necrosis in the renal tissue induced due to gentamicin nephrotoxicity, at the histological levels in terms of the reduction of enlargement and regeneration of the tubular epithelium. Conclusion: Tinospora cordifolia extract constituted flavonoids which are known antioxidants. Co-administration of Tinospora cordifolia stem extract is protective in the nephrotoxic condition induced by drugs, hence, shall benefit the kidney when taken along while consuming potentially nephrotoxic drugs.
{"title":"Co-administration with Tinospora cordifolia attenuates drug induced nephrotoxicity – A histological and biochemical assessment","authors":"Janani Maheshwari V. Vyas, S. Kumar S., Leena Dennis Joseph, K. P, S. R","doi":"10.51248/.v43i3.1698","DOIUrl":"https://doi.org/10.51248/.v43i3.1698","url":null,"abstract":"Introduction and Aim: Various herbs have been prescribed as a cure for renal disorders by early literature. Nephroprotective herbs are protective against nephrotoxicity. Tinospora cordifolia is known for its role in treating diabetes and disorders of the kidney and metabolism. However, studying its protective effect on drug induced nephrotoxicity at different time periods is wanting. The aim is to study the nephroprotective effect of Tinospora cordifolia on drug induced nephrotoxic changes upon co-administration of the herb with nephrotoxicity induction by the drug.\u0000 \u0000Materials and Methods: Ethanolic extract of the stem of Tinospora cordifolia was prepared and evaluated for phytochemical constituents. Gentamicin induced nephrotoxicity model in adult, male, Wistar rats was utilised for the study. Gentamicin and the extract of Tinospora cordifolia were co-administered for 8 days. In the kidney, levels of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were measured. Assessment of the renal tissue was carried out using histopathological severity grading.\u0000 \u0000Results: Phytochemicals like glycosides, flavonoids, saponins, steroids, quinone and coumarin were present in the stem of Tinospora cordifolia. Analysing the levels of oxidative stress and antioxidants in the kidney revealed the rise in the level of reduced glutathione (GSH). This correlated with the regenerative changes brought about by the herbal extract on the acute tubular necrosis in the renal tissue induced due to gentamicin nephrotoxicity, at the histological levels in terms of the reduction of enlargement and regeneration of the tubular epithelium.\u0000 \u0000Conclusion: Tinospora cordifolia extract constituted flavonoids which are known antioxidants. Co-administration of Tinospora cordifolia stem extract is protective in the nephrotoxic condition induced by drugs, hence, shall benefit the kidney when taken along while consuming potentially nephrotoxic drugs.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42560329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramana K., K. A, P. Suganthirababu, Surya Vishnuram, D. S, J. Alagesan
Introduction and Aim: Low back muscle endurance is becoming a major issue because of low back ache. Though many treatment protocols have been suggested and proved effective, endurance exercises have been under less researched area over its effectiveness in comparison to other treatment protocols. The purpose of this study is to determine the effect of trunk extensor muscle endurance training with conventional spinal exercise for trunk extensor muscle in subjects with LBP. Materials and Methods: This is a quasi-experimental study involving 56 patients in the age group of 25-35 years who were allocated in the experimental group (endurance exercises) and control group (conventional spinal exercise) for 3 times per week, for 6 weeks for a duration of 30-45 minutes. Outcome measures used for the study were McGill Pain Questionnaire, RMDQ, 60 sec. spinal extension endurance tests. Results: There was no significant difference found within group analysis in all outcome measures. In between, the group analysis experimental group has shown statistically significant difference in all outcome measures at post-test with the p-value of 0.000. Conclusion: Endurance training has proved to be a much more effective method and provides faster recovery than conventional spinal extension exercise in treatment of patients with subacute low back pain.
{"title":"Effect of trunk muscle endurance training in pain management and function in sub-acute low back pain – A quasi experimental study","authors":"Ramana K., K. A, P. Suganthirababu, Surya Vishnuram, D. S, J. Alagesan","doi":"10.51248/.v43i3.404","DOIUrl":"https://doi.org/10.51248/.v43i3.404","url":null,"abstract":"Introduction and Aim: Low back muscle endurance is becoming a major issue because of low back ache. Though many treatment protocols have been suggested and proved effective, endurance exercises have been under less researched area over its effectiveness in comparison to other treatment protocols. The purpose of this study is to determine the effect of trunk extensor muscle endurance training with conventional spinal exercise for trunk extensor muscle in subjects with LBP.\u0000 \u0000Materials and Methods: This is a quasi-experimental study involving 56 patients in the age group of 25-35 years who were allocated in the experimental group (endurance exercises) and control group (conventional spinal exercise) for 3 times per week, for 6 weeks for a duration of 30-45 minutes. Outcome measures used for the study were McGill Pain Questionnaire, RMDQ, 60 sec. spinal extension endurance tests.\u0000 \u0000Results: There was no significant difference found within group analysis in all outcome measures. In between, the group analysis experimental group has shown statistically significant difference in all outcome measures at post-test with the p-value of 0.000.\u0000 \u0000Conclusion: Endurance training has proved to be a much more effective method and provides faster recovery than conventional spinal extension exercise in treatment of patients with subacute low back pain.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44870769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Yrysov, N. Arstanbekov, M. Mamytov, Akylbek Akmataliev, Bakytbek Turganbaev, Yethindra Vityala
Introduction and Aim: A benign tumor of the central nervous system known as a meningioma of the brain can be effectively treated surgically to assure complete patient recovery. The objective of this study was to investigate intracranial postoperative complications in meningiomas, identify factors that are prognostically significant, assess the results of surgical therapy, and provide rational solutions for difficulties associated with brain meningiomas. Materials and Methods: The 202 observations of patients with supratentorial meningiomas who had surgery provided the basis for the current study. In the 20 patients who survived, we looked at a number of surgical problems. Clinical evaluation and instrumental diagnostic methods were used to confirm their nature. Results: Most patients with basal located meningiomas experience surgical issues. Meningiomas were discovered to be basal in 12 (60.0%) of the survivors who encountered postoperative complications. Patients with postoperative complications from meningiomas frequently encountered many cumulative issues, with a death rate of 5 (2.5%) and one or occasionally two complications in survivors. Conclusion: The growth of tumors, surgical trauma, and the body's general reaction to the removal of neoplasms all affect the body's activity at all levels (subcellular, cellular, organ, and systemic) in patients with supratentorial meningiomas, leading to postoperative complications.
{"title":"Postoperative complications in patients with intracranial meningiomas who underwent surgery","authors":"K. Yrysov, N. Arstanbekov, M. Mamytov, Akylbek Akmataliev, Bakytbek Turganbaev, Yethindra Vityala","doi":"10.51248/.v43i3.2886","DOIUrl":"https://doi.org/10.51248/.v43i3.2886","url":null,"abstract":"Introduction and Aim: A benign tumor of the central nervous system known as a meningioma of the brain can be effectively treated surgically to assure complete patient recovery. The objective of this study was to investigate intracranial postoperative complications in meningiomas, identify factors that are prognostically significant, assess the results of surgical therapy, and provide rational solutions for difficulties associated with brain meningiomas.\u0000 \u0000Materials and Methods: The 202 observations of patients with supratentorial meningiomas who had surgery provided the basis for the current study. In the 20 patients who survived, we looked at a number of surgical problems. Clinical evaluation and instrumental diagnostic methods were used to confirm their nature.\u0000 \u0000Results: Most patients with basal located meningiomas experience surgical issues. Meningiomas were discovered to be basal in 12 (60.0%) of the survivors who encountered postoperative complications. Patients with postoperative complications from meningiomas frequently encountered many cumulative issues, with a death rate of 5 (2.5%) and one or occasionally two complications in survivors.\u0000 \u0000Conclusion: The growth of tumors, surgical trauma, and the body's general reaction to the removal of neoplasms all affect the body's activity at all levels (subcellular, cellular, organ, and systemic) in patients with supratentorial meningiomas, leading to postoperative complications.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44077126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. G. V., Vatsala K. B., Soumya Gupta, M. Mohan, Deepa Adiga, Cheryl Sarah Philipose, Ranjitha Rao
Introduction and Aim: Cervicofacial actinomycosis is a rare chronic granulomatous disease caused by Actinomyces and is the commonest subtype of actinomycosis. Due to the similarities in clinical presentation, cervicofacial actinomycosis is almost always suspected as malignancy or tuberculosis. Histopathological evaluation is crucial in diagnosis and management of these cases. The aim of the study was to evaluate the clinicopathological features of cervicofacial actinomycosis in the biopsy specimens. Methodology: This is a retrospective cross sectional observational study of 17 years duration. All cases of cervicofacial actinomycosis diagnosed on biopsy specimens were analyzed. Clinical presentations and histomorphological features were evaluated on hematoxylin and eosin-stained slides with confirmation of organism on special stains. Results: Out of 36 diagnosed cases of actinomycosis during the study period, we evaluated 16 cases (44.4%) of cervicofacial actinomycosis. Mean age of presentation was 38 years. Male to female ratio was 1:0.9. The anatomical sites of eight (50%) were in the oral cavity, six (37.5%) on the face and two (12.5%) in the neck. Two cases (12.5%) had sinuses discharging sulphur granules. Six cases (37.5%) were clinically suspected as malignant and among them two cases (12.5%) also had differential diagnosis of tuberculosis. All cases on histomorphology showed sulphur granules consisting of basophilic filamentous bacterial colonies with Splendore Hoeppli phenomenon and mixed inflammation. On special stains, the bacterial colonies were Gram, PAS and GMS stain positive, and acid fast negative. Conclusion: Cervicofacial actinomycosis are uncommon. Their presentation can mimic carcinoma or tuberculosis. Consistent histomorphological features can direct towards identification of organisms by special stains for confirmation of diagnosis.
{"title":"Clinicopathological spectrum of cervicofacial actinomycosis","authors":"C. G. V., Vatsala K. B., Soumya Gupta, M. Mohan, Deepa Adiga, Cheryl Sarah Philipose, Ranjitha Rao","doi":"10.51248/.v43i3.2506","DOIUrl":"https://doi.org/10.51248/.v43i3.2506","url":null,"abstract":"Introduction and Aim: Cervicofacial actinomycosis is a rare chronic granulomatous disease caused by Actinomyces and is the commonest subtype of actinomycosis. Due to the similarities in clinical presentation, cervicofacial actinomycosis is almost always suspected as malignancy or tuberculosis. Histopathological evaluation is crucial in diagnosis and management of these cases. The aim of the study was to evaluate the clinicopathological features of cervicofacial actinomycosis in the biopsy specimens.\u0000 \u0000Methodology: This is a retrospective cross sectional observational study of 17 years duration. All cases of cervicofacial actinomycosis diagnosed on biopsy specimens were analyzed. Clinical presentations and histomorphological features were evaluated on hematoxylin and eosin-stained slides with confirmation of organism on special stains.\u0000 \u0000Results: Out of 36 diagnosed cases of actinomycosis during the study period, we evaluated 16 cases (44.4%) of cervicofacial actinomycosis. Mean age of presentation was 38 years. Male to female ratio was 1:0.9. The anatomical sites of eight (50%) were in the oral cavity, six (37.5%) on the face and two (12.5%) in the neck. Two cases (12.5%) had sinuses discharging sulphur granules. Six cases (37.5%) were clinically suspected as malignant and among them two cases (12.5%) also had differential diagnosis of tuberculosis. All cases on histomorphology showed sulphur granules consisting of basophilic filamentous bacterial colonies with Splendore Hoeppli phenomenon and mixed inflammation. On special stains, the bacterial colonies were Gram, PAS and GMS stain positive, and acid fast negative.\u0000 \u0000Conclusion: Cervicofacial actinomycosis are uncommon. Their presentation can mimic carcinoma or tuberculosis. Consistent histomorphological features can direct towards identification of organisms by special stains for confirmation of diagnosis.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45695958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aghil Soorya Aravindakshan, Raghavendra L. S. Hallur, Sameer Sharma
Introduction and Aim: Trichosanthes lobata is one of the species which belongs to Chinese traditional medicine for the therapeutic purpose of antioxidant properties. Free radicals’ production by the body has numerous beneficial roles including in immune systems, cellular signaling pathways, mitogenic response, and synthesis of cellular structures. This study aimed to evaluate the therapeutic efficacy of the T. lobata secondary metabolites toward COX proteins and validate their antioxidant potential. Materials and Methods: We extracted the plant using Soxhlet and subjected it to various assays like DPPH and TEAC, followed by in silico analysis. The molecular docking and dynamic simulation have been analyzed with respect to the protein of interest against selected phytochemicals from T. lobata. Results: We observed the significant outcome from DPPH and TEAC assays like reducing the capability in contrast to T. lobata followed by docking and dynamic stability. Conclusion: The current findings have unveiled that the investigated flora, namely T. lobata, is a bastion of secondary phytochemicals. The plant's exceptional antioxidant capacity is attributable to the occurrence of one or more of these secondary metabolites, which exert their respective or synergistic effects.
{"title":"In silico analysis of Trichosanthes lobata extracts: A promising source of antioxidants for therapeutic applications","authors":"Aghil Soorya Aravindakshan, Raghavendra L. S. Hallur, Sameer Sharma","doi":"10.51248/.v43i3.2912","DOIUrl":"https://doi.org/10.51248/.v43i3.2912","url":null,"abstract":"Introduction and Aim: Trichosanthes lobata is one of the species which belongs to Chinese traditional medicine for the therapeutic purpose of antioxidant properties. Free radicals’ production by the body has numerous beneficial roles including in immune systems, cellular signaling pathways, mitogenic response, and synthesis of cellular structures. This study aimed to evaluate the therapeutic efficacy of the T. lobata secondary metabolites toward COX proteins and validate their antioxidant potential.\u0000 \u0000Materials and Methods: We extracted the plant using Soxhlet and subjected it to various assays like DPPH and TEAC, followed by in silico analysis. The molecular docking and dynamic simulation have been analyzed with respect to the protein of interest against selected phytochemicals from T. lobata.\u0000 \u0000Results: We observed the significant outcome from DPPH and TEAC assays like reducing the capability in contrast to T. lobata followed by docking and dynamic stability.\u0000 \u0000Conclusion: The current findings have unveiled that the investigated flora, namely T. lobata, is a bastion of secondary phytochemicals. The plant's exceptional antioxidant capacity is attributable to the occurrence of one or more of these secondary metabolites, which exert their respective or synergistic effects.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44175632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction and Aim: Metabolic flexibility of fungi is unique among organisms. Fungi can produce various pigments of industrial importance. Potential of Talaromyces ruber for beneficial pigments needs to be explored. Hence, the present study aims at the detection of pigments from T. ruber and determining their antimicrobial properties. Materials and Methods: A soil isolate of T. ruber was tested for pigment production. Cellular and secretory pigments were extracted. They were separated by thin-layer chromatography (TLC) and detected by UV-Visible spectrophotometry. The antibacterial activities of crude pigments were tested by disc diffusion method. The antifungal activity was detected by disc diffusion method, conidial germination inhibition assay and bioautography methods. Results: The results showed that cellular metabolites yielded seven pigment fractions and secretory metabolites yielded five different pigment fractions in TLC. In UV-Visible spectrometry, the absorption range of visible light with 370 to 412 nm detected yellow pigments and absorption of 500 to 520 nm detected red pigments. Crude cellular and secretory pigment fractions showed inhibition activity only on Bacillus subtilis. The antifungal activity of both crude cellular and secretory pigments was observed against Candida albicans and Cryptococcus sp. The secretory crude pigment showed conidial germination inhibition only against Alternaria tenuissima. In bioautography, the cellular and secretory crude pigments showed an inhibition zone for Cladosporium oxysporum. Additionally, secretory crude pigment showed similar activity against Curvularia lunata. Interestingly, the variations in the antifungals between cellular and secretory pigment fractions are also evident. Production of antimicrobial compounds from T. ruber was established after the detection of pigment fractions. Conclusion: Potential of T. ruber to produce yellow and red pigments was realized. Antimicrobial pigments from T. ruber were detected providing scope to develop for industrial scale. These pigments may be used in pharmaceutical and nutritional industries.
{"title":"Bioprospecting of Talaromyces ruber pigments for antimicrobials","authors":"Narendrababu B. N., Shishupala S.","doi":"10.51248/.v43i3.2667","DOIUrl":"https://doi.org/10.51248/.v43i3.2667","url":null,"abstract":"Introduction and Aim: Metabolic flexibility of fungi is unique among organisms. Fungi can produce various pigments of industrial importance. Potential of Talaromyces ruber for beneficial pigments needs to be explored. Hence, the present study aims at the detection of pigments from T. ruber and determining their antimicrobial properties.\u0000 \u0000Materials and Methods: A soil isolate of T. ruber was tested for pigment production. Cellular and secretory pigments were extracted. They were separated by thin-layer chromatography (TLC) and detected by UV-Visible spectrophotometry. The antibacterial activities of crude pigments were tested by disc diffusion method. The antifungal activity was detected by disc diffusion method, conidial germination inhibition assay and bioautography methods.\u0000 \u0000Results: The results showed that cellular metabolites yielded seven pigment fractions and secretory metabolites yielded five different pigment fractions in TLC. In UV-Visible spectrometry, the absorption range of visible light with 370 to 412 nm detected yellow pigments and absorption of 500 to 520 nm detected red pigments. Crude cellular and secretory pigment fractions showed inhibition activity only on Bacillus subtilis. The antifungal activity of both crude cellular and secretory pigments was observed against Candida albicans and Cryptococcus sp. The secretory crude pigment showed conidial germination inhibition only against Alternaria tenuissima. In bioautography, the cellular and secretory crude pigments showed an inhibition zone for Cladosporium oxysporum. Additionally, secretory crude pigment showed similar activity against Curvularia lunata. Interestingly, the variations in the antifungals between cellular and secretory pigment fractions are also evident. Production of antimicrobial compounds from T. ruber was established after the detection of pigment fractions.\u0000 \u0000Conclusion: Potential of T. ruber to produce yellow and red pigments was realized. Antimicrobial pigments from T. ruber were detected providing scope to develop for industrial scale. These pigments may be used in pharmaceutical and nutritional industries.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41919012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T.H. Teppeeva, K. Karymshakova, Meerim Makenzhanova, A. Zhumabekova
Introduction and Aim: Endometrial hyperplasia (EH) is a common cause of malignant tumors and a major health risk for perimenopausal women. In this study, systemic immunological markers in women with climacteric syndrome (CS) and EH will be examined in relation to the EH treatment option Mirena® levonorgestrel-releasing intrauterine device (LNG-IUS). Materials and Methods: Examining 350 premenopausal women, 84 (23.4%) were diagnosed with EH. The type of EH was identified in 84 patients using a histological study and a diagnostic curettage of the uterine cavity. In view of more severe and considerable systemic immunity abnormalities in women with CS and EH, the indirect effect of levonorgestrel's intrauterine microdose excretion on systemic immunity was examined. Results: Mirena® LNG-IUS has an indirect immune-corrective effect on systemic and humoral immunity in women with EH who have a pathological climatic course. It does this by stabilizing the neutrophil pool, activating the receptor function, and stabilizing the absorption and metabolic activity of neutrophilic phagocytes in the humoral system. Conclusion: Due to the pathological progression of menopause and the appearance of EH, alterations in women's reproductive system during this period led to a significant decrease in the signs of CS after the first month of using Mirena® LNG-IUS.
{"title":"Effectiveness of Mirena® LNG-IUS in treating women with endometrial hyperplasia and climacteric syndrome","authors":"T.H. Teppeeva, K. Karymshakova, Meerim Makenzhanova, A. Zhumabekova","doi":"10.51248/.v43i3.2888","DOIUrl":"https://doi.org/10.51248/.v43i3.2888","url":null,"abstract":"Introduction and Aim: Endometrial hyperplasia (EH) is a common cause of malignant tumors and a major health risk for perimenopausal women. In this study, systemic immunological markers in women with climacteric syndrome (CS) and EH will be examined in relation to the EH treatment option Mirena® levonorgestrel-releasing intrauterine device (LNG-IUS).\u0000 \u0000Materials and Methods: Examining 350 premenopausal women, 84 (23.4%) were diagnosed with EH. The type of EH was identified in 84 patients using a histological study and a diagnostic curettage of the uterine cavity. In view of more severe and considerable systemic immunity abnormalities in women with CS and EH, the indirect effect of levonorgestrel's intrauterine microdose excretion on systemic immunity was examined.\u0000 \u0000Results: Mirena® LNG-IUS has an indirect immune-corrective effect on systemic and humoral immunity in women with EH who have a pathological climatic course. It does this by stabilizing the neutrophil pool, activating the receptor function, and stabilizing the absorption and metabolic activity of neutrophilic phagocytes in the humoral system.\u0000 \u0000Conclusion: Due to the pathological progression of menopause and the appearance of EH, alterations in women's reproductive system during this period led to a significant decrease in the signs of CS after the first month of using Mirena® LNG-IUS.","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43379095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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