Pub Date : 2023-09-21DOI: 10.58806/ijhmr.2023.v2i9n05
Arinze I. Aninworie, MD, MSc
Background and aim: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. It is curable in the early stages but has a poor prognosis when advanced. Current diagnostic protocols for the early stages of HCC are inefficient. Serum Glypican-3 (GPC-3) is a promising serum tumour marker in diagnosing HCC, and its diagnostic value has been explored in various studies. The outcomes, however, continue to be inconsistent and controversial. This systematic review and meta-analysis aimed to investigate the diagnostic accuracy of serum GPC-3 in hepatocellular carcinoma. This study included recent papers not captured in previous meta-analyses. Method: PUBMED, MEDLINE, Cochrane Library, and CINAHL databases were systematically searched according to preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies guidelines. Studies on the diagnostic accuracy of serum GPC-3 in HCC were selected. The Quality assessment of diagnostic accuracy studies 2 (QUADAS-2) tools were used to assess the quality of selected studies. Sensitivity, specificity, and other diagnostic parameters were pooled using the random effect model. The Summary receiver operating characteristic (sROC) was used to summarise the diagnostic accuracy of Serum GPC-3. Results: Eleven studies were included in this systematic review. The pooled sensitivity, specificity, and 95% confidence intervals (CIs) were 0.60 (0.57-0.62) and 0.67(0.64-0.70), respectively. The pooled positive and negative likelihood ratios and 95% CIs were 2.11 (1.51-2.93) and 0.59 (0.51-0.68), respectively; the pooled diagnostic odds ratio and the 95% CI were 4.07 (2.37-6.98), the area under the sROC curve was 0.7194. Conclusion: This meta-analysis has shown that Serum GPC-3 has an acceptable diagnostic value in diagnosing HCC compared to benign chronic liver diseases. A higher-quality study with a larger sample size is necessary to thoroughly assess the diagnostic utility of serum GPC-3.
{"title":"The Diagnostic Value Of Serum Glypican-3 In The Diagnosis Of Hepatocellular Carcinoma: A Systematic Review And Meta-Analysis","authors":"Arinze I. Aninworie, MD, MSc","doi":"10.58806/ijhmr.2023.v2i9n05","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i9n05","url":null,"abstract":"Background and aim: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. It is curable in the early stages but has a poor prognosis when advanced. Current diagnostic protocols for the early stages of HCC are inefficient. Serum Glypican-3 (GPC-3) is a promising serum tumour marker in diagnosing HCC, and its diagnostic value has been explored in various studies. The outcomes, however, continue to be inconsistent and controversial. This systematic review and meta-analysis aimed to investigate the diagnostic accuracy of serum GPC-3 in hepatocellular carcinoma. This study included recent papers not captured in previous meta-analyses. Method: PUBMED, MEDLINE, Cochrane Library, and CINAHL databases were systematically searched according to preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies guidelines. Studies on the diagnostic accuracy of serum GPC-3 in HCC were selected. The Quality assessment of diagnostic accuracy studies 2 (QUADAS-2) tools were used to assess the quality of selected studies. Sensitivity, specificity, and other diagnostic parameters were pooled using the random effect model. The Summary receiver operating characteristic (sROC) was used to summarise the diagnostic accuracy of Serum GPC-3. Results: Eleven studies were included in this systematic review. The pooled sensitivity, specificity, and 95% confidence intervals (CIs) were 0.60 (0.57-0.62) and 0.67(0.64-0.70), respectively. The pooled positive and negative likelihood ratios and 95% CIs were 2.11 (1.51-2.93) and 0.59 (0.51-0.68), respectively; the pooled diagnostic odds ratio and the 95% CI were 4.07 (2.37-6.98), the area under the sROC curve was 0.7194. Conclusion: This meta-analysis has shown that Serum GPC-3 has an acceptable diagnostic value in diagnosing HCC compared to benign chronic liver diseases. A higher-quality study with a larger sample size is necessary to thoroughly assess the diagnostic utility of serum GPC-3.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136155455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linear IgA bullous dermatosis is a rare subepidermal bullous disease that can occur idiopathically or to be drug-induced. The disease affects both the skin and mucous membranes in children and adults. Drug-induced linear Ig A bullous dermatosis occurs more often in elderly patients who suffer from various chronic and systemic diseases. Among the most frequently reported medications causing the disease are non-steroidal anti-inflammatory drugs, antibiotics, anticoagulants, statins, ACE-inhibitors. In this report, we present a case of etoricoxib-induced linear Ig A bullous dermatosis in a woman with no known comorbidities at the time of hospitalization.
{"title":"Etoricoxib-Induced Linear IgA Bullous Dermatosis","authors":"Zhenya Stoyanova, Filka Georgieva, Yoanna Velevska","doi":"10.58806/ijhmr.2023.v2i9n03","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i9n03","url":null,"abstract":"Linear IgA bullous dermatosis is a rare subepidermal bullous disease that can occur idiopathically or to be drug-induced. The disease affects both the skin and mucous membranes in children and adults. Drug-induced linear Ig A bullous dermatosis occurs more often in elderly patients who suffer from various chronic and systemic diseases. Among the most frequently reported medications causing the disease are non-steroidal anti-inflammatory drugs, antibiotics, anticoagulants, statins, ACE-inhibitors. In this report, we present a case of etoricoxib-induced linear Ig A bullous dermatosis in a woman with no known comorbidities at the time of hospitalization.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135059200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scabies surrepticius represents the non-classic atypical presentation of scabies and diagnosing scabies in these individuals could be difficult. We present a clinical case of a 71-year-old woman with intense body pruritus for about 2 years, unresponsive to oral and topical antibiotics, corticosteroid creams, topical calcineurin inhibitors, as well as antiallergic agents, due to a suspected allergic reaction.
{"title":"Scabies Surrepticus Presenting As Chronic Urticaria – A Case Report And Literally Review Of Diagnosis Method And Treatment","authors":"Yoanna Velevska, Filka Georgieva, Zhenya Stoyanova","doi":"10.58806/ijhmr.2023.v2i9n04","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i9n04","url":null,"abstract":"Scabies surrepticius represents the non-classic atypical presentation of scabies and diagnosing scabies in these individuals could be difficult. We present a clinical case of a 71-year-old woman with intense body pruritus for about 2 years, unresponsive to oral and topical antibiotics, corticosteroid creams, topical calcineurin inhibitors, as well as antiallergic agents, due to a suspected allergic reaction.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135059849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-13DOI: 10.58806/ijhmr.2023.v2i9n02
Manjusha Mahajan, Venkata Satyanarayana Nanduri
Introduction: An anal fissure manifests as a painful longitudinal tear in the anoderm distal to the dentate line with symptoms of pain during defecation, rectal bleeding, tremendous emotional stress, and declined quality of life. Anal fissures are found more frequently in women. Several treatment options are available with or without medication and/or surgery. This paper presents 4 cases of patients affected by anal fissures healed by one healer and cured successfully by the application of Yoga Prana Vidya (YPV) healing protocols as alternative medicine. Method: This paper uses the case study method by collecting medical data from the 4 patients (3 female and 1 male), YPV healer’s records, and patient feedback. Results: Patient in case 1 became normal after 37 healing sessions of 20 minutes each in 1 ½ months of YPV healing. The patient in case 2 became normal after 25 sessions of 20 minutes of YPV healing conducted in 17 days. The patient in case 3 became normal after 35 sessions of 20 minutes each within a period of about 7 weeks of healing. The patient in case 4 became normal after 10 sessions of 20 minutes of healing within 11 days. Conclusions: This paper presented multiple cases of anal fissures suffered by patients over many years that have been cured successfully by the application of the integrated and holistic system of Yoga Prana Vidya (YPV) healing protocols. Further research is recommended. Recommendations include training Healthcare workers for applying YPV techniques complementary to their respective professions for treating patients holistically and as a preventive modality boosting immunity.
{"title":"Anal Fissures: A Case Series Study On How Yoga Prana Vidya (YPV) HealingProtocols Treated This Condition And Associated Symptoms","authors":"Manjusha Mahajan, Venkata Satyanarayana Nanduri","doi":"10.58806/ijhmr.2023.v2i9n02","DOIUrl":"https://doi.org/10.58806/ijhmr.2023.v2i9n02","url":null,"abstract":"Introduction: An anal fissure manifests as a painful longitudinal tear in the anoderm distal to the dentate line with symptoms of pain during defecation, rectal bleeding, tremendous emotional stress, and declined quality of life. Anal fissures are found more frequently in women. Several treatment options are available with or without medication and/or surgery. This paper presents 4 cases of patients affected by anal fissures healed by one healer and cured successfully by the application of Yoga Prana Vidya (YPV) healing protocols as alternative medicine. Method: This paper uses the case study method by collecting medical data from the 4 patients (3 female and 1 male), YPV healer’s records, and patient feedback. Results: Patient in case 1 became normal after 37 healing sessions of 20 minutes each in 1 ½ months of YPV healing. The patient in case 2 became normal after 25 sessions of 20 minutes of YPV healing conducted in 17 days. The patient in case 3 became normal after 35 sessions of 20 minutes each within a period of about 7 weeks of healing. The patient in case 4 became normal after 10 sessions of 20 minutes of healing within 11 days. Conclusions: This paper presented multiple cases of anal fissures suffered by patients over many years that have been cured successfully by the application of the integrated and holistic system of Yoga Prana Vidya (YPV) healing protocols. Further research is recommended. Recommendations include training Healthcare workers for applying YPV techniques complementary to their respective professions for treating patients holistically and as a preventive modality boosting immunity.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135740447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-08DOI: 10.21744/ijhms.v6n3.2192
Rina Wijayanti, Dina Raidanti
Cervical cancer is a serious problem in Indonesia. Many cases and deaths occur because early detection is less than optimal. To overcome this, WHO recommends Visual Inspection With Acetic Acid (VIA) as an effective screening method for detecting pre-cancerous lesions early. However, unfortunately, the coverage of VIA inspections is still low in several areas, including in West Java, such as Depok City, Karawang Regency, and Bekasi Regency. Therefore, this problem is interesting to study. This study aims to determine the Knowledge, Attitude, Motivation, and Husband Support in Women of childbearing age with an Interest in Checking for Visual Inspection with Acetic Acid (VIA) at TPMB Bidan R Cisalak Pasar Cimanggis Depok Year 2022. The method in this study used quantitative research using descriptive analytic methods with a cross-sectional approach. The sample used amounted to 32 people. Data analysis used the chi–square test statistic. The results of this study indicate that there is a significant relationship between the level of knowledge and support from husbands of women of childbearing age by conducting VIA checking. However, there is no relationship between the level of attitude and motivation of women of childbearing age by carrying out a VIA check.
宫颈癌在印度尼西亚是一个严重的问题。许多病例和死亡的发生是因为早期发现不够理想。为了克服这一点，世卫组织建议将醋酸目视检查(VIA)作为早期发现癌前病变的有效筛查方法。然而，不幸的是，VIA检查的覆盖率在几个地区仍然很低，包括西爪哇，如Depok City, Karawang Regency和Bekasi Regency。因此，这个问题很值得研究。本研究旨在了解在2022年Bidan R Cisalak Pasar Cimanggis Depok TPMB有兴趣进行醋酸目视检查(VIA)的育龄妇女的知识、态度、动机和丈夫支持。本研究的方法采用定量研究，采用描述性分析方法和横断面方法。所使用的样本共计32人。数据分析采用卡方检验统计量。通过VIA检验，本研究结果表明育龄妇女的知识水平与丈夫的支持之间存在显著的关系。然而，通过进行VIA检查，育龄妇女的态度水平与动机之间没有关系。
{"title":"Knowledge, attitude, motivation and husband support in women of childbearing age with the interest of checking for visual inspection with acetic acid (VIA) at TPMB Bidan R Cisalak Pasar Cimanggis Depok Year 2022","authors":"Rina Wijayanti, Dina Raidanti","doi":"10.21744/ijhms.v6n3.2192","DOIUrl":"https://doi.org/10.21744/ijhms.v6n3.2192","url":null,"abstract":"Cervical cancer is a serious problem in Indonesia. Many cases and deaths occur because early detection is less than optimal. To overcome this, WHO recommends Visual Inspection With Acetic Acid (VIA) as an effective screening method for detecting pre-cancerous lesions early. However, unfortunately, the coverage of VIA inspections is still low in several areas, including in West Java, such as Depok City, Karawang Regency, and Bekasi Regency. Therefore, this problem is interesting to study. This study aims to determine the Knowledge, Attitude, Motivation, and Husband Support in Women of childbearing age with an Interest in Checking for Visual Inspection with Acetic Acid (VIA) at TPMB Bidan R Cisalak Pasar Cimanggis Depok Year 2022. The method in this study used quantitative research using descriptive analytic methods with a cross-sectional approach. The sample used amounted to 32 people. Data analysis used the chi–square test statistic. The results of this study indicate that there is a significant relationship between the level of knowledge and support from husbands of women of childbearing age by conducting VIA checking. However, there is no relationship between the level of attitude and motivation of women of childbearing age by carrying out a VIA check.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136362336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-08DOI: 10.21744/ijhms.v6n3.2191
Devi Yulianti, Christin Jayanti
Colostrum is the first breast milk rich in benefits for babies and ideally given before exclusive breastfeeding. WHO and Unicef recommend giving breast milk one hour after birth, as all babies need colostrum to fight infections, which is estimated to save one million baby lives. However, over 90% of mothers discard colostrum, mainly due to lack of information. In Indonesia, the coverage of colostrum provision is still low, requiring further research. This study aims to determine the relationship between postpartum mothers' knowledge and the provision of colostrum to newborns at the Tanah Abang Sub-District Health Center. The study is descriptive-analytic with a cross-sectional approach. The sample consists of 32 postpartum mothers registered at the Tanah Abang Sub-District Health Center, selected using accidental sampling. Data collection is done using a questionnaire, and data analysis uses the chi-square test. The research results show that the p-value is 0.000, thus rejecting the null hypothesis (Ho) and accepting the alternative hypothesis (Ha). These findings indicate a significant relationship between mothers' knowledge and the provision of colostrum to newborns. In conclusion, maternal knowledge significantly influences the behavior of providing colostrum to newborns.
{"title":"relationship between postpartum mother's knowledge and colostrum provision to newborns at the Tanah Abang Sub-District Health Center","authors":"Devi Yulianti, Christin Jayanti","doi":"10.21744/ijhms.v6n3.2191","DOIUrl":"https://doi.org/10.21744/ijhms.v6n3.2191","url":null,"abstract":"Colostrum is the first breast milk rich in benefits for babies and ideally given before exclusive breastfeeding. WHO and Unicef recommend giving breast milk one hour after birth, as all babies need colostrum to fight infections, which is estimated to save one million baby lives. However, over 90% of mothers discard colostrum, mainly due to lack of information. In Indonesia, the coverage of colostrum provision is still low, requiring further research. This study aims to determine the relationship between postpartum mothers' knowledge and the provision of colostrum to newborns at the Tanah Abang Sub-District Health Center. The study is descriptive-analytic with a cross-sectional approach. The sample consists of 32 postpartum mothers registered at the Tanah Abang Sub-District Health Center, selected using accidental sampling. Data collection is done using a questionnaire, and data analysis uses the chi-square test. The research results show that the p-value is 0.000, thus rejecting the null hypothesis (Ho) and accepting the alternative hypothesis (Ha). These findings indicate a significant relationship between mothers' knowledge and the provision of colostrum to newborns. In conclusion, maternal knowledge significantly influences the behavior of providing colostrum to newborns.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136361343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-10DOI: 10.21744/ijhms.v5n1.1858
M. R. Khidoyatova, U. K. Kayumov, Feruza Khidoyatovna Inoyatova, K. Fozilov, G. Khamidullaeva, Aziz Sagdullaevich Eshpulatov
The main goal of our study was to identify the activity of cardiac dysfunction based on the analysis of the main cardiological methods of research, such as ECG, echocardiography, 24-hour ECG monitoring in conjunction with laboratory parameters in patients with coronary artery disease (CAD) who underwent mild and moderate COVID-19, without signs of residual effects of lung tissue damage (fibrotization). 52 patients with coronary artery disease were examined, which were divided into 2 groups depending on the past infection in history: 1 group without COVID-19 in history (n=26) (based on history and results of SARS-CoV-2 antibody titer), 2 a group with a history of COVID-19 (n=26), confirmed by relevant documents (tests), but without oxygen therapy and steroids, in order to avoid the influence of a serious illness and drug exposure. Conclusions: dynamic monitoring of hemostasis parameters after the hospital stage in patients with CAD should be carried out in order to prevent adverse cardiovascular outcomes, even with a history of moderate and mild coronavirus infection. One of the aspects of therapeutic rehabilitation in the post-COVID period in patients with IHD is the use of vitamin D preparations.
{"title":"Clinical status of patients with coronary artery disease post COVID-19","authors":"M. R. Khidoyatova, U. K. Kayumov, Feruza Khidoyatovna Inoyatova, K. Fozilov, G. Khamidullaeva, Aziz Sagdullaevich Eshpulatov","doi":"10.21744/ijhms.v5n1.1858","DOIUrl":"https://doi.org/10.21744/ijhms.v5n1.1858","url":null,"abstract":"The main goal of our study was to identify the activity of cardiac dysfunction based on the analysis of the main cardiological methods of research, such as ECG, echocardiography, 24-hour ECG monitoring in conjunction with laboratory parameters in patients with coronary artery disease (CAD) who underwent mild and moderate COVID-19, without signs of residual effects of lung tissue damage (fibrotization). 52 patients with coronary artery disease were examined, which were divided into 2 groups depending on the past infection in history: 1 group without COVID-19 in history (n=26) (based on history and results of SARS-CoV-2 antibody titer), 2 a group with a history of COVID-19 (n=26), confirmed by relevant documents (tests), but without oxygen therapy and steroids, in order to avoid the influence of a serious illness and drug exposure. Conclusions: dynamic monitoring of hemostasis parameters after the hospital stage in patients with CAD should be carried out in order to prevent adverse cardiovascular outcomes, even with a history of moderate and mild coronavirus infection. One of the aspects of therapeutic rehabilitation in the post-COVID period in patients with IHD is the use of vitamin D preparations.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83804692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-05DOI: 10.21744/ijhms.v5n1.1851
Andhika Tomy Permana, Nur Setiawan Suroto, M. Parenrengi, A. Bajamal, Pudji Lestari, A. Fauzi
Stroke is one of the most important causes of morbidity and mortality worldwide, with survivors subjected to long-term disability. Stroke is classified as ischemic and hemorrhagic. 87 % of strokes are classified as ischemic. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by an ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons to improve neurological recovery. Further understanding of the mechanisms by which the stem cells exert their beneficial effect could potentially revolutionize the field. The next decade of stem cell research in stroke needs to focus on. Although still in need of exploration, stem cell treatments for stroke may offer ways to protect and replace neurons to improve outcomes for stroke patients.
{"title":"Current update on stroke ischemic management","authors":"Andhika Tomy Permana, Nur Setiawan Suroto, M. Parenrengi, A. Bajamal, Pudji Lestari, A. Fauzi","doi":"10.21744/ijhms.v5n1.1851","DOIUrl":"https://doi.org/10.21744/ijhms.v5n1.1851","url":null,"abstract":"Stroke is one of the most important causes of morbidity and mortality worldwide, with survivors subjected to long-term disability. Stroke is classified as ischemic and hemorrhagic. 87 % of strokes are classified as ischemic. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by an ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons to improve neurological recovery. Further understanding of the mechanisms by which the stem cells exert their beneficial effect could potentially revolutionize the field. The next decade of stem cell research in stroke needs to focus on. Although still in need of exploration, stem cell treatments for stroke may offer ways to protect and replace neurons to improve outcomes for stroke patients.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84217270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-05DOI: 10.21744/ijhms.v5n1.1852
Dirga Rachmad Aprianto, M. Parenrengi, Budi Utomo, A. Fauzi, E. Subagyo
The use of implants in pediatric cranioplasty is still debatable. Many surgeons prefer to use autologous bone grafts than implants due to previous concerns that implants have a higher risk of infection, allergic response, and are not biocompatible as an autologous bone graft. However, recent studies showed that several implant materials have a similar infection rate following cranioplasty or might be lower compared to autologous bone. Moreover, several studies also reported a high rate of bone flap resorption in autograft cranioplasty, particularly in patients below the age of 8 years, thus requiring revision surgery with an implant as a substitute in most cases. Implant materials also have advantages in several conditions that make them more suitable than autologous bone grafts. This literature review is expected to give information about the type of implant materials that can be used as an alternative to substitute autologous bone grafts in certain conditions.
{"title":"Autograft and implant cranioplasty in pediatric patients","authors":"Dirga Rachmad Aprianto, M. Parenrengi, Budi Utomo, A. Fauzi, E. Subagyo","doi":"10.21744/ijhms.v5n1.1852","DOIUrl":"https://doi.org/10.21744/ijhms.v5n1.1852","url":null,"abstract":"The use of implants in pediatric cranioplasty is still debatable. Many surgeons prefer to use autologous bone grafts than implants due to previous concerns that implants have a higher risk of infection, allergic response, and are not biocompatible as an autologous bone graft. However, recent studies showed that several implant materials have a similar infection rate following cranioplasty or might be lower compared to autologous bone. Moreover, several studies also reported a high rate of bone flap resorption in autograft cranioplasty, particularly in patients below the age of 8 years, thus requiring revision surgery with an implant as a substitute in most cases. Implant materials also have advantages in several conditions that make them more suitable than autologous bone grafts. This literature review is expected to give information about the type of implant materials that can be used as an alternative to substitute autologous bone grafts in certain conditions.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79551714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-04DOI: 10.21744/ijhms.v5n1.1848
Mahendra Budi Sagita, A. Turchan, Budi Utomo, A. Fauzi, D. Fauziah
Neurological damage in brain injury occurs due to secondary brain injury. Kencur extract has antioxidant potential with total phenolic and flavonoid content including luteolin apigenin and is expected to reduce MDA expression to prevent secondary injury. This study is an experimental laboratory. The treatment of all samples was carried out simultaneously using a post-test-only control group design. Based on the ANOVA test, the significance value of the Kencur extract treatment group was 0.000 (p<0.05) indicating that there was a difference in MDA expression in brain-injured rats without kencur extract with brain-injured rats and given kencur extract. In the 24-hour and 48-hour time groups, a significance value of 0.488 (p> 0.05) showed no significant difference in MDA expression. Then the Kencur extract treatment group with a time group of 0.117 (p> 0.05) showed no significant difference in MDA expression. There was a significant difference in the expression of MDA in brain-injured rats without kencur extract with brain-injured rats and given kencur extract. There were no significant differences in the MDA expression in the 24-hour and 48-hour time groups and the Kencur extract treatment group and the 24-hour and 48-hour time groups.
{"title":"Expression malondialdehyde (MDA) of brain after injury with the extract of kencur (Kaempferia Galanga L)","authors":"Mahendra Budi Sagita, A. Turchan, Budi Utomo, A. Fauzi, D. Fauziah","doi":"10.21744/ijhms.v5n1.1848","DOIUrl":"https://doi.org/10.21744/ijhms.v5n1.1848","url":null,"abstract":"Neurological damage in brain injury occurs due to secondary brain injury. Kencur extract has antioxidant potential with total phenolic and flavonoid content including luteolin apigenin and is expected to reduce MDA expression to prevent secondary injury. This study is an experimental laboratory. The treatment of all samples was carried out simultaneously using a post-test-only control group design. Based on the ANOVA test, the significance value of the Kencur extract treatment group was 0.000 (p<0.05) indicating that there was a difference in MDA expression in brain-injured rats without kencur extract with brain-injured rats and given kencur extract. In the 24-hour and 48-hour time groups, a significance value of 0.488 (p> 0.05) showed no significant difference in MDA expression. Then the Kencur extract treatment group with a time group of 0.117 (p> 0.05) showed no significant difference in MDA expression. There was a significant difference in the expression of MDA in brain-injured rats without kencur extract with brain-injured rats and given kencur extract. There were no significant differences in the MDA expression in the 24-hour and 48-hour time groups and the Kencur extract treatment group and the 24-hour and 48-hour time groups.","PeriodicalId":51699,"journal":{"name":"International Journal of Medical Research & Health Sciences","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76143190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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