Pub Date : 2026-01-16DOI: 10.1016/j.mmcr.2026.100763
Yuanying Zeng, Dan Chen, Fang Yang, Huaying Liu, Yuelin He, Chunfu Li
In patients with immune deficiencies, fusarium solani infections have a poor prognosis and a high mortality rate. Previous reports revealed patients with disseminated Fusarium infections often ultimately succumb to multi-organ failure, however, specific organs involved in the initial stages of failure and the progression of cardiopulmonary injuries are not described in detail. We here report the development of cardiopulmonary failure in two consecutive patients with fusarium solani infections.
{"title":"Fusarium solani infection induced cardiopulmonary failure in immunocompromised patients: Two case reports","authors":"Yuanying Zeng, Dan Chen, Fang Yang, Huaying Liu, Yuelin He, Chunfu Li","doi":"10.1016/j.mmcr.2026.100763","DOIUrl":"10.1016/j.mmcr.2026.100763","url":null,"abstract":"<div><div>In patients with immune deficiencies, <em>fusarium solani</em> infections have a poor prognosis and a high mortality rate. Previous reports revealed patients with disseminated Fusarium infections often ultimately succumb to multi-organ failure, however, specific organs involved in the initial stages of failure and the progression of cardiopulmonary injuries are not described in detail. We here report the development of cardiopulmonary failure in two consecutive patients with <em>fusarium solani</em> infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100763"},"PeriodicalIF":1.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.mmcr.2026.100764
Xosse Carreras , Francisco Machiavello Roman
Immunocompromised patients are at risk of complex invasive fungal infections. We report the case of a patient with profound immunosuppression following allogeneic stem cell transplantation who presented with a concurrent pulmonary infection due to Aspergillus nidulans and Verruconis spp. This case highlights the therapeutic challenges of managing simultaneous aspergillosis and phaeohyphomycosis in a patient with significant immune compromise.
{"title":"Concurrent pulmonary aspergillosis and phaeohyphomycosis due to Verruconis spp. in a stem cell transplant recipient with chronic graft-versus-host disease","authors":"Xosse Carreras , Francisco Machiavello Roman","doi":"10.1016/j.mmcr.2026.100764","DOIUrl":"10.1016/j.mmcr.2026.100764","url":null,"abstract":"<div><div>Immunocompromised patients are at risk of complex invasive fungal infections. We report the case of a patient with profound immunosuppression following allogeneic stem cell transplantation who presented with a concurrent pulmonary infection due to <em>Aspergillus nidulans</em> and <em>Verruconis</em> spp. This case highlights the therapeutic challenges of managing simultaneous aspergillosis and phaeohyphomycosis in a patient with significant immune compromise.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100764"},"PeriodicalIF":1.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.mmcr.2026.100760
Zhengxiang Lv , Xiaodong Liu , Ping Xu
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric morbidity. We report a 23-year-old female with APS who developed cryptococcal meningitis (CM) following immunosuppressive therapy. Diagnosed via cerebrospinal fluid (CSF) culture and MRI showing infarction, she had concomitant renal and hepatic failure, making amphotericin B contraindicated. Consequently, an individualized regimen comprising voriconazole and 5-fluorocytosine (5-FC) was initiated, resulting in significant clinical improvement. This case underscores that CM is a serious opportunistic infection in patients undergoing immunosuppression for APS, highlighting the need for vigilant monitoring and tailored antifungal strategies for multi-organ dysfunction.
{"title":"Uncommon clinical presentations and diagnostic difficulties of antiphospholipid syndrome associated with cryptococcal meningitis: A case study","authors":"Zhengxiang Lv , Xiaodong Liu , Ping Xu","doi":"10.1016/j.mmcr.2026.100760","DOIUrl":"10.1016/j.mmcr.2026.100760","url":null,"abstract":"<div><div>Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric morbidity. We report a 23-year-old female with APS who developed cryptococcal meningitis (CM) following immunosuppressive therapy. Diagnosed via cerebrospinal fluid (CSF) culture and MRI showing infarction, she had concomitant renal and hepatic failure, making amphotericin B contraindicated. Consequently, an individualized regimen comprising voriconazole and 5-fluorocytosine (5-FC) was initiated, resulting in significant clinical improvement. This case underscores that CM is a serious opportunistic infection in patients undergoing immunosuppression for APS, highlighting the need for vigilant monitoring and tailored antifungal strategies for multi-organ dysfunction.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100760"},"PeriodicalIF":1.3,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coccidioidomycosis is an endemic fungal infection that rarely presents as isolated osteoarticular disease in immunocompetent hosts. We report a case of disseminated coccidioidomycosis manifesting as chronic septic arthritis of the tibiofemoral joint without apparent pulmonary involvement in a 32-year-old male. Diagnostic delay and initial immunosuppressive therapy contributed to disease progression. Histopathology confirmed the diagnosis and combined surgical debridement and prolonged antifungal therapy led to favorable outcomes. This case highlights the importance of considering fungal etiologies in chronic monoarthritis in endemic regions.
{"title":"Isolated knee septic arthritis revealing disseminated coccidioidomycosis without apparent pulmonary involvement: A case report","authors":"Elias Ledezma Flores , Arturo Urias Pompa , Ariadna Betsabel Heredia Pulido , César Noé López Barrón","doi":"10.1016/j.mmcr.2026.100759","DOIUrl":"10.1016/j.mmcr.2026.100759","url":null,"abstract":"<div><div>Coccidioidomycosis is an endemic fungal infection that rarely presents as isolated osteoarticular disease in immunocompetent hosts. We report a case of disseminated coccidioidomycosis manifesting as chronic septic arthritis of the tibiofemoral joint without apparent pulmonary involvement in a 32-year-old male. Diagnostic delay and initial immunosuppressive therapy contributed to disease progression. Histopathology confirmed the diagnosis and combined surgical debridement and prolonged antifungal therapy led to favorable outcomes. This case highlights the importance of considering fungal etiologies in chronic monoarthritis in endemic regions.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100759"},"PeriodicalIF":1.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145978203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aspergillus mastoiditis with skull base osteomyelitis is an exceptionally rare but life-threatening infection in patients undergoing peritoneal dialysis (PD). We report a 60-year-old man with diabetic kidney failure on PD who developed invasive Aspergillus flavus mastoiditis progressing to skull base osteomyelitis. Despite early mastoidectomy, PD catheter removal, and voriconazole therapy achieving therapeutic levels, the infection advanced to involve the carotid sheath and parapharyngeal space, resulting in severe neurologic and systemic complications. Molecular sequencing confirmed A. flavus, excluding cryptic species such as A. tamarii. This case represents the first documented instance of skull base invasive aspergillosis in a PD patient and underscores the importance of early suspicion, species-level molecular confirmation, and multidisciplinary management in this formidable and rapidly progressive condition.
{"title":"Skull base invasive aspergillosis in a peritoneal dialysis patient: A rare and devastating complication","authors":"Nattapakorn Mai-on , Rubash Nath Yogi , Piyaporn Towangnang , Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2025.100758","DOIUrl":"10.1016/j.mmcr.2025.100758","url":null,"abstract":"<div><div><em>Aspergillus</em> mastoiditis with skull base osteomyelitis is an exceptionally rare but life-threatening infection in patients undergoing peritoneal dialysis (PD). We report a 60-year-old man with diabetic kidney failure on PD who developed invasive <em>Aspergillus flavus</em> mastoiditis progressing to skull base osteomyelitis. Despite early mastoidectomy, PD catheter removal, and voriconazole therapy achieving therapeutic levels, the infection advanced to involve the carotid sheath and parapharyngeal space, resulting in severe neurologic and systemic complications. Molecular sequencing confirmed <em>A. flavus</em>, excluding cryptic species such as <em>A. tamarii</em>. This case represents the first documented instance of skull base invasive aspergillosis in a PD patient and underscores the importance of early suspicion, species-level molecular confirmation, and multidisciplinary management in this formidable and rapidly progressive condition.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100758"},"PeriodicalIF":1.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.mmcr.2025.100757
Neema Pithia , Margie Morgan , Thea Tagliaferro , Priya R. Soni
Extremely preterm neonates are at heightened risk for invasive fungal infections. We report a fatal case of Aspergillus flavus infection in a 25-week infant, outlining the clinical course, antifungal treatment, and challenges in management. This case highlights the need for early recognition, rapid biopsy and aggressive therapy in vulnerable neonates.
{"title":"An invasive Aspergillus flavus infection in an extremely preterm neonate: a case report","authors":"Neema Pithia , Margie Morgan , Thea Tagliaferro , Priya R. Soni","doi":"10.1016/j.mmcr.2025.100757","DOIUrl":"10.1016/j.mmcr.2025.100757","url":null,"abstract":"<div><div>Extremely preterm neonates are at heightened risk for invasive fungal infections. We report a fatal case of <em>Aspergillus flavus</em> infection in a 25-week infant, outlining the clinical course, antifungal treatment, and challenges in management. This case highlights the need for early recognition, rapid biopsy and aggressive therapy in vulnerable neonates.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100757"},"PeriodicalIF":1.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sporotrichosis is a neglected fungal disease, affecting mammals. Here, a feline patient presented a small ulcerated lesion. Short treatment by itraconazole resulted in clinical cure. The isolate was identified as Sporothrix brunneoviolacea by sequencing. Despite proper growth, antifungal susceptibility testing by microbroth dilution could not be performed due to a lack of growth. This is the first report of sporotrichosis by S. brunneoviolacea, which was originally classified as an environmental and non-pathogenic species.
{"title":"First report of sporotrichosis by Sporothrix brunneoviolacea","authors":"Mariana Rodrgiues Trápaga , Bram Spruijtenburg , Bruna Jacomel , Jéssica Estefânia Dávila Hidalgo , Karine Ortiz Sanchotene , Fabiana Fedatto Bernardon , Bruna Muradás Esperon , Vanice Rodrigues Poester , Theun de Groot , Eelco F.J. Meijer , Melissa Orzechowski Xavier","doi":"10.1016/j.mmcr.2025.100756","DOIUrl":"10.1016/j.mmcr.2025.100756","url":null,"abstract":"<div><div>Sporotrichosis is a neglected fungal disease, affecting mammals. Here, a feline patient presented a small ulcerated lesion. Short treatment by itraconazole resulted in clinical cure. The isolate was identified as <em>Sporothrix brunneoviolacea</em> by sequencing. Despite proper growth, antifungal susceptibility testing by microbroth dilution could not be performed due to a lack of growth. This is the first report of sporotrichosis by <em>S. brunneoviolacea</em>, which was originally classified as an environmental and non-pathogenic species.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100756"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1016/j.mmcr.2025.100755
Huiyu Zhang , Yahui Feng , Yiping Liang , Sisi Wang , Dongmei Shi
We report the case of a 66-year-old woman with a 40-year history of a chronic Fusarium proliferatum infection on the right auricle. In vitro susceptibility testing showed resistance to common antifungals, including voriconazole and amphotericin B. Following the failure of conventional antifungal therapies, 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) was initiated as monotherapy. The patient underwent 10 treatment sessions, with the ALA concentration and light parameters adjusted based on the auricle's anatomy. Post-treatment follow-up demonstrated complete resolution of the lesions, with no recurrence or scar formation observed. This case highlights the efficacy and safety of ALA-PDT for multidrug-resistant Fusarium proliferatum infections in specific anatomical sites, providing a valuable alternative for clinical management of refractory superficial fungal infections.
{"title":"Successful treatment of 40-year chronic auricular cutaneous infection caused by multidrug-resistant Fusarium proliferatum via 5-aminolevulinic acid photodynamic therapy: A case report","authors":"Huiyu Zhang , Yahui Feng , Yiping Liang , Sisi Wang , Dongmei Shi","doi":"10.1016/j.mmcr.2025.100755","DOIUrl":"10.1016/j.mmcr.2025.100755","url":null,"abstract":"<div><div>We report the case of a 66-year-old woman with a 40-year history of a chronic <em>Fusarium proliferatum</em> infection on the right auricle. In vitro susceptibility testing showed resistance to common antifungals, including voriconazole and amphotericin B. Following the failure of conventional antifungal therapies, 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) was initiated as monotherapy. The patient underwent 10 treatment sessions, with the ALA concentration and light parameters adjusted based on the auricle's anatomy. Post-treatment follow-up demonstrated complete resolution of the lesions, with no recurrence or scar formation observed. This case highlights the efficacy and safety of ALA-PDT for multidrug-resistant <em>Fusarium proliferatum</em> infections in specific anatomical sites, providing a valuable alternative for clinical management of refractory superficial fungal infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100755"},"PeriodicalIF":1.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1016/j.mmcr.2025.100754
Beatrice Z. Sim, Amanda Seidenfeld, Jessica Focht, Jennifer Saullo, Manuela Carugati
Blastomyces dermatitidis, a dimorphic fungal infection endemic to North America, is typically associated with pulmonary disease, but may also disseminate. We report the case of a 54-year-old female liver transplant recipient who developed blastomycosis with cutaneous and likely pulmonary involvement. She was successfully treated with posaconazole, an alternative to itraconazole with a favorable safety and interaction profile, demonstrating the therapeutic potential of posaconazole as a primary agent for blastomycosis in transplant recipients.
{"title":"Disseminated cutaneous blastomycosis in a liver transplant recipient: A case report","authors":"Beatrice Z. Sim, Amanda Seidenfeld, Jessica Focht, Jennifer Saullo, Manuela Carugati","doi":"10.1016/j.mmcr.2025.100754","DOIUrl":"10.1016/j.mmcr.2025.100754","url":null,"abstract":"<div><div><em>Blastomyces dermatitidis,</em> a dimorphic fungal infection endemic to North America, is typically associated with pulmonary disease, but may also disseminate. We report the case of a 54-year-old female liver transplant recipient who developed blastomycosis with cutaneous and likely pulmonary involvement. She was successfully treated with posaconazole, an alternative to itraconazole with a favorable safety and interaction profile, demonstrating the therapeutic potential of posaconazole as a primary agent for blastomycosis in transplant recipients.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100754"},"PeriodicalIF":1.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.mmcr.2025.100752
Hongzhen Shu , Xiaofeng Li , Yuying Chen , Weihong Wang
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis (DH) is rare and often misdiagnosed, especially in non-endemic areas. We present a case of a 70-year-old Chinese man who was admitted with fever, nausea, and vomiting, initially misdiagnosed with pulmonary tuberculosis. The use of metagenomic next-generation sequencing (mNGS) played a crucial role in the early and accurate diagnosis, highlighting its potential as a valuable diagnostic tool for rare infections.
{"title":"Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in an HIV-negative patient: A case of misdiagnosis","authors":"Hongzhen Shu , Xiaofeng Li , Yuying Chen , Weihong Wang","doi":"10.1016/j.mmcr.2025.100752","DOIUrl":"10.1016/j.mmcr.2025.100752","url":null,"abstract":"<div><div>Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis (DH) is rare and often misdiagnosed, especially in non-endemic areas. We present a case of a 70-year-old Chinese man who was admitted with fever, nausea, and vomiting, initially misdiagnosed with pulmonary tuberculosis. The use of metagenomic next-generation sequencing (mNGS) played a crucial role in the early and accurate diagnosis, highlighting its potential as a valuable diagnostic tool for rare infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100752"},"PeriodicalIF":1.3,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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