Pub Date : 2025-11-12DOI: 10.1016/j.mmcr.2025.100750
Frantzeska Frantzeskaki , Nikolas Stratopoulos , Sandra Elise van der Griend , Ioannis Renieris , Kostantinos Thomas , Iraklis Tsagkaris
Fusariosis is a severe fungal infection associated with high mortality rates and an increasing incidence. However, its treatment remains challenging due to the frequent resistance of Fusarium species to conventional antifungal therapies. Here, we describe a case of an immunocompetent patient with invasive disseminated fusariosis with multifocal abscess formation after major traumatic injury. We report a significant clinical improvement with clinically relevant reduction of abscesses without major treatment toxicity after treatment with fosmanogepix.
{"title":"Successful treatment of a resistant invasive disseminated Fusarium infection in an immunocompetent patient","authors":"Frantzeska Frantzeskaki , Nikolas Stratopoulos , Sandra Elise van der Griend , Ioannis Renieris , Kostantinos Thomas , Iraklis Tsagkaris","doi":"10.1016/j.mmcr.2025.100750","DOIUrl":"10.1016/j.mmcr.2025.100750","url":null,"abstract":"<div><div>Fusariosis is a severe fungal infection associated with high mortality rates and an increasing incidence. However, its treatment remains challenging due to the frequent resistance of Fusarium species to conventional antifungal therapies. Here, we describe a case of an immunocompetent patient with invasive disseminated fusariosis with multifocal abscess formation after major traumatic injury. We report a significant clinical improvement with clinically relevant reduction of abscesses without major treatment toxicity after treatment with fosmanogepix.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100750"},"PeriodicalIF":1.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.mmcr.2025.100751
Jordan K. Mah , John I. Hogan , Sonya Kothadia , Jeffrey E. Keenan , Johnathan Berger , Manuela Carugati
A cluster of Aspergillus fumigatus donor-derived infections (DDI) was rapidly diagnosed using plasma metagenomic next-generation sequencing (mNGS) among solid organ transplant recipients. The heart recipient, experiencing marginal hemodynamics, underwent an endomyocardial biopsy, which was concerning for a fungal infection on histopathology. Plasma mNGS was performed, identifying A. fumigatus two days prior to conventional diagnostics. This timely diagnosis enabled prompt nephrectomies in the kidney recipients, who survived. This report represents the first published use of mNGS in the diagnosis of Aspergillus fumigatus DDI, highlighting the utility of this novel, underutilized assay for early diagnosis of donor-derived infections.
{"title":"Application of plasma cell-free metagenomic next-generation sequencing for the identification of Aspergillus fumigatus donor-derived infections among solid organ transplant recipients","authors":"Jordan K. Mah , John I. Hogan , Sonya Kothadia , Jeffrey E. Keenan , Johnathan Berger , Manuela Carugati","doi":"10.1016/j.mmcr.2025.100751","DOIUrl":"10.1016/j.mmcr.2025.100751","url":null,"abstract":"<div><div>A cluster of Aspergillus fumigatus donor-derived infections (DDI) was rapidly diagnosed using plasma metagenomic next-generation sequencing (mNGS) among solid organ transplant recipients. The heart recipient, experiencing marginal hemodynamics, underwent an endomyocardial biopsy, which was concerning for a fungal infection on histopathology. Plasma mNGS was performed, identifying A. fumigatus two days prior to conventional diagnostics. This timely diagnosis enabled prompt nephrectomies in the kidney recipients, who survived. This report represents the first published use of mNGS in the diagnosis of Aspergillus fumigatus DDI, highlighting the utility of this novel, underutilized assay for early diagnosis of donor-derived infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100751"},"PeriodicalIF":1.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.mmcr.2025.100749
Carla Rey-Suarez , Paula Caramazana-Lopez , Iván Fernández-Castro , Helena Esteban-Cartelle , Daniel Navarro-de la Cruz , Elena Losada-Arias
Invasive fungal sinusitis by Scedosporium spp. is a rare but severe infection in immunocompromised patients. We report an 80-year-old woman with poorly controlled diabetes and chronic corticosteroid use who presented with headache, hearing loss, and facial paralysis. She was ultimately diagnosed with sphenoid sinusitis due to Scedosporium boydii. Management required surgical debridement and prolonged antifungal therapy complicated by drug-induced liver injury. Early diagnosis and multidisciplinary treatment are crucial to improve prognosis in these complex infections.
{"title":"Invasive fungal sinusitis by Scedosporium boydii in an immunocompromised patient. A case report","authors":"Carla Rey-Suarez , Paula Caramazana-Lopez , Iván Fernández-Castro , Helena Esteban-Cartelle , Daniel Navarro-de la Cruz , Elena Losada-Arias","doi":"10.1016/j.mmcr.2025.100749","DOIUrl":"10.1016/j.mmcr.2025.100749","url":null,"abstract":"<div><div>Invasive fungal sinusitis by <em>Scedosporium</em> spp. is a rare but severe infection in immunocompromised patients. We report an 80-year-old woman with poorly controlled diabetes and chronic corticosteroid use who presented with headache, hearing loss, and facial paralysis. She was ultimately diagnosed with sphenoid sinusitis due to <em>Scedosporium boydii</em>. Management required surgical debridement and prolonged antifungal therapy complicated by drug-induced liver injury. Early diagnosis and multidisciplinary treatment are crucial to improve prognosis in these complex infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100749"},"PeriodicalIF":1.3,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.mmcr.2025.100748
Ailén Dumont-Viollaz , Belén Rivera Gómez-Barris , Gabriel Velozo , Leslye Camila del Río , Byron Guzmán-Marín , Pamela Thomson
In November 2024, a female Chilean Chihuahua presented with a limb lesion that did not heal after spaying. The diagnosis indicated Aureobasidium pullulans infection. The antifungigram showed susceptibility to itraconazole, treatment with this drug together with bilateral amputation resulted in a complete recovery. The phylogenetic tree of the ITS gene showed differences with other sequences of the same species from animals and lichens. This case highlights this environmental fungus as a potential pathogen in dogs.
{"title":"First case of Aureobasidium pullulans in a dog after sterilization surgery in Chile","authors":"Ailén Dumont-Viollaz , Belén Rivera Gómez-Barris , Gabriel Velozo , Leslye Camila del Río , Byron Guzmán-Marín , Pamela Thomson","doi":"10.1016/j.mmcr.2025.100748","DOIUrl":"10.1016/j.mmcr.2025.100748","url":null,"abstract":"<div><div>In November 2024, a female Chilean Chihuahua presented with a limb lesion that did not heal after spaying. The diagnosis indicated <em>Aureobasidium pullulans</em> infection. The antifungigram showed susceptibility to itraconazole, treatment with this drug together with bilateral amputation resulted in a complete recovery. The phylogenetic tree of the ITS gene showed differences with other sequences of the same species from animals and lichens. This case highlights this environmental fungus as a potential pathogen in dogs.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100748"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To our knowledge, this is the first report of Prototheca sp. isolated from the digestive tract of a dolphin. A captive-born female bottlenose dolphin (Tursiops truncatus) weighing 165 kg that was housed at Enoshima Aquarium presented with a slightly elevated body temperature and candida-like yeasts in stomach fluid and feces. Gastroscopy revealed cobblestone-like thickening of the mucosa with a few ulcers in the forestomach. Prototheca bovis was isolated from the biopsy specimen of the lesion.
{"title":"First isolation of Prototheca bovis from a bottlenose dolphin (Tursiops truncatus)","authors":"Chika Shirakata , Kanon Tsurumi , Koichi Makimura , Rui Kano","doi":"10.1016/j.mmcr.2025.100746","DOIUrl":"10.1016/j.mmcr.2025.100746","url":null,"abstract":"<div><div>To our knowledge, this is the first report of <em>Prototheca</em> sp. isolated from the digestive tract of a dolphin. A captive-born female bottlenose dolphin (<em>Tursiops truncatus</em>) weighing 165 kg that was housed at Enoshima Aquarium presented with a slightly elevated body temperature and candida-like yeasts in stomach fluid and feces. Gastroscopy revealed cobblestone-like thickening of the mucosa with a few ulcers in the forestomach. <em>Prototheca bovis</em> was isolated from the biopsy specimen of the lesion.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100746"},"PeriodicalIF":1.3,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-21DOI: 10.1016/j.mmcr.2025.100747
Rajeev Soman, Sanraksha Mayya, Sushrut Ganpule, Geethu Joe
Viral associated pulmonary aspergillosis (VAPA) is increasingly being recognized by clinicians. However, the same patient developing VAPA after two separate viral respiratory illness appears to be rare. We describe a patient who developed influenza associated invasive aspergillosis (IAPA) which resolved completely with treatment. A second episode of VAPA developed after one year following human rhinovirus/enterovirus with a nodular infiltrate at a different location in the lungs as compared to earlier. Neither episode required ICU admission and both episodes were treated successfully.
{"title":"VAPA strikes the patient again!","authors":"Rajeev Soman, Sanraksha Mayya, Sushrut Ganpule, Geethu Joe","doi":"10.1016/j.mmcr.2025.100747","DOIUrl":"10.1016/j.mmcr.2025.100747","url":null,"abstract":"<div><div>Viral associated pulmonary aspergillosis (VAPA) is increasingly being recognized by clinicians. However, the same patient developing VAPA after two separate viral respiratory illness appears to be rare. We describe a patient who developed influenza associated invasive aspergillosis (IAPA) which resolved completely with treatment. A second episode of VAPA developed after one year following human rhinovirus/enterovirus with a nodular infiltrate at a different location in the lungs as compared to earlier. Neither episode required ICU admission and both episodes were treated successfully.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100747"},"PeriodicalIF":1.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-18DOI: 10.1016/j.mmcr.2025.100745
Giuseppe A. Ferrara , Bram Spruijtenburg , Eelco F.J. Meijer , Jacques F. Meis , Andres Ceballos-Garzon , Diego H. Caceres
This study documents the first reported cases of Candida (Candidozyma)auris in the Dominican Republic, isolated from both a critically ill human patient and a captive dolphin. Antifungal susceptibility testing from dolphin isolate showed elevated minimum inhibitory concentrations (MIC) of fluconazole but low MICs of other antifungals, including the novel drugs rezafungin, ibrexafungerp and manogepix. Whole genome sequencing (WGS) of the dolphin isolate allocated it to clade I, but surprisingly did not show any known mutations that confer azole resistance, suggesting a mechanism different from mutations in the genes studied. The concurrent emergence of C. auris in human and animal hosts underscores the importance of a One Health approach, emphasizing the interconnectedness of human, animal, and environmental health, and the need for strengthened surveillance and rigorous infection control measures across medical and veterinary settings.
{"title":"First report of Candida (Candidozyma) auris infections in a human and a dolphin from the Dominican Republic: A One health perspective","authors":"Giuseppe A. Ferrara , Bram Spruijtenburg , Eelco F.J. Meijer , Jacques F. Meis , Andres Ceballos-Garzon , Diego H. Caceres","doi":"10.1016/j.mmcr.2025.100745","DOIUrl":"10.1016/j.mmcr.2025.100745","url":null,"abstract":"<div><div>This study documents the first reported cases of <em>Candida</em> (<em>Candidozyma)auris</em> in the Dominican Republic, isolated from both a critically ill human patient and a captive dolphin. Antifungal susceptibility testing from dolphin isolate showed elevated minimum inhibitory concentrations (MIC) of fluconazole but low MICs of other antifungals, including the novel drugs rezafungin, ibrexafungerp and manogepix. Whole genome sequencing (WGS) of the dolphin isolate allocated it to clade I, but surprisingly did not show any known mutations that confer azole resistance, suggesting a mechanism different from mutations in the genes studied. The concurrent emergence of <em>C. auris</em> in human and animal hosts underscores the importance of a One Health approach, emphasizing the interconnectedness of human, animal, and environmental health, and the need for strengthened surveillance and rigorous infection control measures across medical and veterinary settings.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100745"},"PeriodicalIF":1.3,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-13DOI: 10.1016/j.mmcr.2025.100743
Anne Haglund , Jelena Stankovic , Thomas Decker Christensen , Lise Kristensen , Karen Rokkedal Lausch
We present a complex case of Chronic Pulmonary Aspergillosis (CPA) caused by Aspergillus fumigatus in a pre-existing lung cavity in an immunocompromised patient with granulomatosis with polyangiitis. Initial treatment with voriconazole was limited due to adverse effects and emerging azole resistance.Aspergillus Subsequent therapy with intravenous and intracavitary amphotericin B was also poorly tolerated and clinically insufficient. The patient underwent left-sided thoracotomy with decortication. As a novel approach, the patient recieved Post-surgical instillation of liposomal amphotericin B directly into the resected cavity, combined with systemic antifungal therapy. Subsequently the patient recovered with long-term remission. This case highlights the potential role of post-operative intracavitary antifungal instillation as an adjunctive strategy in refractory CPA, particularly when conventional medical therapy fails.2012 Elsevier Ltd. All rights reserved.
{"title":"Combined intracavitary, systemic antifungal and surgical treatment of Chronic Pulmonary Aspergillosis: experience from an immunocompromised patient","authors":"Anne Haglund , Jelena Stankovic , Thomas Decker Christensen , Lise Kristensen , Karen Rokkedal Lausch","doi":"10.1016/j.mmcr.2025.100743","DOIUrl":"10.1016/j.mmcr.2025.100743","url":null,"abstract":"<div><div>We present a complex case of Chronic Pulmonary Aspergillosis (CPA) caused by <em>Aspergillus fumigatus</em> in a pre-existing lung cavity in an immunocompromised patient with granulomatosis with polyangiitis. Initial treatment with voriconazole was limited due to adverse effects and emerging azole resistance.<em>Aspergillus</em> Subsequent therapy with intravenous and intracavitary amphotericin B was also poorly tolerated and clinically insufficient. The patient underwent left-sided thoracotomy with decortication. As a novel approach, the patient recieved Post-surgical instillation of liposomal amphotericin B directly into the resected cavity, combined with systemic antifungal therapy. Subsequently the patient recovered with long-term remission. This case highlights the potential role of post-operative intracavitary antifungal instillation as an adjunctive strategy in refractory CPA, particularly when conventional medical therapy fails.2012 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100743"},"PeriodicalIF":1.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1016/j.mmcr.2025.100744
Yingyi He , Rong Hu , Li Yuan , Weiqiang Xiao , Xiaoling Su , Li Huang
Disseminated mucormycosis is a rare and often fatal infection, primarily affecting immunocompromised individuals. Its diagnosis is extremely challenging, as definitive identification of organisms in tissue by histopathology with culture confirmation can be invasive, slow, and insensitive. We present the case of a 12-month-old female with Hemophagocytic Lymphohistiocytosis (HLH), triggered by a high Epstein-Barr virus (EBV) viral load and complicated by an underlying NK-cell perforin deficiency. Despite rapid HLH-specific and maximal supportive care, the patient developed life-threatening mucormycosis with extensive gastrointestinal involvement. Clinicians should note insidious signs, such as a black eschar and hypodense lesions on MRI imaging findings, indicative of tissue infarction from hyphal vascular invasion in these susceptible hosts. Prompt invasive testing of involved organs is critical upon suspicion.
{"title":"Disseminated mucormycosis leading to a fatal gastrointestinal perforation in a pediatric case of EBV-associated Hemophagocytic lymphohistiocytosis","authors":"Yingyi He , Rong Hu , Li Yuan , Weiqiang Xiao , Xiaoling Su , Li Huang","doi":"10.1016/j.mmcr.2025.100744","DOIUrl":"10.1016/j.mmcr.2025.100744","url":null,"abstract":"<div><div>Disseminated mucormycosis is a rare and often fatal infection, primarily affecting immunocompromised individuals. Its diagnosis is extremely challenging, as definitive identification of organisms in tissue by histopathology with culture confirmation can be invasive, slow, and insensitive. We present the case of a 12-month-old female with Hemophagocytic Lymphohistiocytosis (HLH), triggered by a high Epstein-Barr virus (EBV) viral load and complicated by an underlying NK-cell perforin deficiency. Despite rapid HLH-specific and maximal supportive care, the patient developed life-threatening mucormycosis with extensive gastrointestinal involvement. Clinicians should note insidious signs, such as a black eschar and hypodense lesions on MRI imaging findings, indicative of tissue infarction from hyphal vascular invasion in these susceptible hosts. Prompt invasive testing of involved organs is critical upon suspicion.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100744"},"PeriodicalIF":1.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145333277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-30DOI: 10.1016/j.mmcr.2025.100742
Fabianne Carlesse , Adriana Maria Paixao De Sousa DA. Silva , Barbara Pinto Nasr , Luiz Fernando Teixeira , Henrique Manoel Lederman , Ana Virginia Lopes de Sousa
{"title":"Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis","authors":"Fabianne Carlesse , Adriana Maria Paixao De Sousa DA. Silva , Barbara Pinto Nasr , Luiz Fernando Teixeira , Henrique Manoel Lederman , Ana Virginia Lopes de Sousa","doi":"10.1016/j.mmcr.2025.100742","DOIUrl":"10.1016/j.mmcr.2025.100742","url":null,"abstract":"","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100742"},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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