DMITRY PARSHIN, Vyacheslav Mykhaylichenko, A. Kupriyanov, Ramazan Alibekov, R. Mardanov, Enver Kеrimov, G. Puchkina, O. Bezrukov, A. Abdullaev
We carried out a single-center study of the effectiveness of polyvalent bacteriophages and oxygenated water for the prevention of SSI. The object was 88 patients who had undergone abdominal surgery for emergency abdominal pathology with a high risk of SSI >30±3% (ACS NSQIP). Phages were administered topically and enterally, while OW only enterally. As a result of the study, it turned out that the combined use of PVBP and OW allows to normalize the induced enteral pathobiome, to reduce pathogen contamination, to enhance the protective capabilities of enterocytes, to stop intestinal failure in the early stages and to reduce the risk of SSI by more than 2 times.
{"title":"POLYVALENT BACTERIOPHAGES AND OXYGENATED WATER – POSSIBILITIES FOR PREVENTION OF SURGICAL SITE INFECTION DURING EMERGENCY ABDOMINAL SURGERY","authors":"DMITRY PARSHIN, Vyacheslav Mykhaylichenko, A. Kupriyanov, Ramazan Alibekov, R. Mardanov, Enver Kеrimov, G. Puchkina, O. Bezrukov, A. Abdullaev","doi":"10.35630/2023/13/4.812","DOIUrl":"https://doi.org/10.35630/2023/13/4.812","url":null,"abstract":"We carried out a single-center study of the effectiveness of polyvalent bacteriophages and oxygenated water for the prevention of SSI. The object was 88 patients who had undergone abdominal surgery for emergency abdominal pathology with a high risk of SSI >30±3% (ACS NSQIP). Phages were administered topically and enterally, while OW only enterally. As a result of the study, it turned out that the combined use of PVBP and OW allows to normalize the induced enteral pathobiome, to reduce pathogen contamination, to enhance the protective capabilities of enterocytes, to stop intestinal failure in the early stages and to reduce the risk of SSI by more than 2 times.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48903358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Reva, Tatsuo Yamamoto, E. Mozhilevskaya, Ekaterina Zinkova, Alexander Zolotov, Anatoliy Soroka, Pavel Zhibanov, Evgeny Bondar, Y. Krasnikov, Rodion Gorbarenko, Julia Gainulina, G. Reva
In solid malignant tumors, as well as in hematological tumors, cancer stem cells (CSCs), quiescent, pluripotent, self-renewing neoplastic, also known as tumor initiating cells, have been identified. CSC tumors are resistant not only to chemotherapy, but also to radiation therapy, as well as they play their role in the occurrence of relapses after surgical treatment, An unfavorable prognosis due to an aggressive course and complications after treatment of the most common primary brain tumor - glioblastoma multiforme (GBM), is also associated with CSC. One of the mechanisms that affect the physiological regeneration of tissues, but do not work under conditions of malignancy, is the environment and composition of the cellular tumor ensemble, represented by the phenotypes of cellular and adaptive immunity. Using immunohistochemical phenotyping methods, the authors identified immunocytes/phagocytes and established the features of their localization in the malignant tissue and at the border around the tumor. It was concluded that due to apoptosis around the tumor, intercellular signaling and migration of immunocytes/phagocytes to the focus of the tumor process are disrupted. The primary tumor process is not associated with damage to the tissue cambium genome, but with the migration of immature stem cells of the hematogenous pool, capable of proliferating and partially entering into incomplete differentiation under conditions of hypoxia and the absence of blood vessels. At the second stage, connective tissue is formed, which grows into vessels, the wall of which is represented by immature endothelium, with impaired transport function. According to the authors, metastasis of cancer cells does not occur by hematogenous and lymphogenous pathways, but is associated with the development of additional foci of hematopoiesis as a result of the adaptation of the human body to the loss of stem and semi-stem cells, precursors for normal regeneration of the nervous tissue.
{"title":"CELLULAR PHENOTYPES OF GLIOBLASTOMA AND PROGNOSIS OF TUMOR OUTCOME","authors":"I. Reva, Tatsuo Yamamoto, E. Mozhilevskaya, Ekaterina Zinkova, Alexander Zolotov, Anatoliy Soroka, Pavel Zhibanov, Evgeny Bondar, Y. Krasnikov, Rodion Gorbarenko, Julia Gainulina, G. Reva","doi":"10.35630/2023/13/4.814","DOIUrl":"https://doi.org/10.35630/2023/13/4.814","url":null,"abstract":"In solid malignant tumors, as well as in hematological tumors, cancer stem cells (CSCs), quiescent, pluripotent, self-renewing neoplastic, also known as tumor initiating cells, have been identified. CSC tumors are resistant not only to chemotherapy, but also to radiation therapy, as well as they play their role in the occurrence of relapses after surgical treatment, An unfavorable prognosis due to an aggressive course and complications after treatment of the most common primary brain tumor - glioblastoma multiforme (GBM), is also associated with CSC. One of the mechanisms that affect the physiological regeneration of tissues, but do not work under conditions of malignancy, is the environment and composition of the cellular tumor ensemble, represented by the phenotypes of cellular and adaptive immunity. Using immunohistochemical phenotyping methods, the authors identified immunocytes/phagocytes and established the features of their localization in the malignant tissue and at the border around the tumor. It was concluded that due to apoptosis around the tumor, intercellular signaling and migration of immunocytes/phagocytes to the focus of the tumor process are disrupted. The primary tumor process is not associated with damage to the tissue cambium genome, but with the migration of immature stem cells of the hematogenous pool, capable of proliferating and partially entering into incomplete differentiation under conditions of hypoxia and the absence of blood vessels. At the second stage, connective tissue is formed, which grows into vessels, the wall of which is represented by immature endothelium, with impaired transport function. According to the authors, metastasis of cancer cells does not occur by hematogenous and lymphogenous pathways, but is associated with the development of additional foci of hematopoiesis as a result of the adaptation of the human body to the loss of stem and semi-stem cells, precursors for normal regeneration of the nervous tissue.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48790221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Europäische Wissenschaftliche Gesellschaft Home About the Journal Peer Review Editorial Board For Authors Reviewer Recognition Archive Contact Impressum EWG e.V. Crossref Member Badge Erfolgreich durch internationale Zusammenarbeit OBSTETRICS DOI 10.35630/2023/13/4.817 Received 11 July 2023; Accepted 19 July 2023, Published 15 August 2023 THE ROLE OF UTEROCERVICAL ANGLE IN DETERMINING THE THREAT OF PRETERM BIRTH Ufuk Atlıhan orcid id logo , Umit Derundere orcid id logo Private Karatas Hospital, Izmir, Turkey download article (pdf) cfl.ufuk@gmail.com ABSTRACT Preterm labor is one of the leading causes of perinatal morbidity and mortality and is thought to complicate approximately 10-12% of pregnancies. Defined as birth before 37 weeks of gestation, preterm labor is one of the most common obstetric complications worldwide. Although the pathogenesis of preterm labor is not fully understood, intraamniotic infection or hemorrhage, uteroplacental ischemia, uterine overstretching and immunologic processes have been proposed in its etiology. However, there is still no definitive prediction tool. Sonographic assessment of the cervical structure by measuring cervical length (CL) has been used as a popular prediction tool to predict preterm labor. The uterocervical angle (UCA) is defined as the angle between the lower anterior uterine segment and the endocervical canal. Recently, UCA has been proposed as an alternative to CL for predicting preterm labor. In recent years, several studies have investigated the potential impact of UCA for preterm labor prediction. Our study aimed to determine whether the uterocervical angle, a new ultrasonographic marker for predicting preterm labor, is associated with the risk of spontaneous preterm delivery. The present study included 186 singleton pregnant women who gave birth in our hospital between January 2018 and December 2022. The data of the included patients were retrospectively evaluated from the hospital database and patient files. Regarding the primary outcome of our study, we found that there was a statistically significant difference in UCA and cervical length between women who delivered spontaneously preterm and women who delivered at term (p<0.05). In the second trimester ultrasonography evaluation, the mean UCA was wider and the mean cervical length was shorter in the preterm group. Contrary to other studies in the literature, smoking and history of preterm delivery as risk factors were not included in our study. The exact reasons for some of the differences between our findings and the studies reported in the literature are not clear, but may be attributed to several factors. First, the patient type was heterogeneously selected in the cited studies. There are large differences in terms of sample size and studies that may be attributed to such heterogeneity. In conclusion, wider UCA and shorter cervical length in the second trimester are associated with spontaneous preterm delivery. Measurement of UCA is a re
Europäische Wissenschaftliche Gesellschaft首页关于期刊同行评议编辑委员会作者评审认可档案联系方式:Impressum EWG e.V. Crossref成员Badge Erfolgreich durch internationale Zusammenarbeit OBSTETRICS DOI 10.35630/2023/13/4.817收到2023年7月11日;子宫-宫颈角度在确定早产威胁中的作用Ufuk Atlıhan土耳其伊兹密尔私立卡拉塔斯医院下载文章(pdf) cfl.ufuk@gmail.com摘要早产是围产期发病率和死亡率的主要原因之一，据认为约有10-12%的妊娠并发症。早产定义为妊娠37周前出生，是全世界最常见的产科并发症之一。虽然早产的发病机制尚不完全清楚，但羊膜内感染或出血、子宫胎盘缺血、子宫过伸和免疫过程已被提出其病因。然而，目前仍没有明确的预测工具。超声通过测量宫颈长度(CL)来评估宫颈结构已被用作预测早产的常用预测工具。子宫宫颈角(UCA)定义为子宫前段下部与宫颈内管之间的角度。最近，UCA被提议作为CL预测早产的替代方法。近年来，一些研究调查了UCA对早产预测的潜在影响。我们的研究旨在确定子宫宫颈角度是否与自发性早产的风险有关，子宫宫颈角度是预测早产的一种新的超声标记。本研究纳入2018年1月至2022年12月在我院分娩的186名单胎孕妇。从医院数据库和患者档案中回顾性评估纳入患者的资料。关于我们研究的主要结局，我们发现自然早产妇女和足月分娩妇女的UCA和宫颈长度有统计学意义(p<0.05)。在妊娠中期超声评估中，早产儿组平均UCA更宽，平均宫颈长度更短。与文献中的其他研究相反，吸烟和早产史并没有被纳入我们的研究。我们的发现与文献中报道的研究之间的一些差异的确切原因尚不清楚，但可能归因于几个因素。首先，在被引用的研究中，患者类型的选择存在异质性。在样本量和研究方面存在很大差异，这可能归因于这种异质性。综上所述，妊娠中期较宽的UCA和较短的宫颈长度与自发性早产有关。UCA的测量是一种可重复的技术，发现UCA值从妊娠早期到妊娠中期增加。我们建议在当前的临床实践中，除了宫颈长度测量外，还应纳入UCA作为一种预测因素，用于对有早产风险的妇女进行管理决策。然而，未来的研究需要评估该指标的诊断准确性，并应特别考虑阈值的使用和相关结果(基于特定妊娠周的早产率)。
{"title":"THE ROLE OF UTEROCERVICAL ANGLE IN DETERMINING THE THREAT OF PRETERM BIRTH","authors":"Ufuk Atlıhan, Umit Derundere","doi":"10.35630/2023/13/4.817","DOIUrl":"https://doi.org/10.35630/2023/13/4.817","url":null,"abstract":"Europäische Wissenschaftliche Gesellschaft Home About the Journal Peer Review Editorial Board For Authors Reviewer Recognition Archive Contact Impressum EWG e.V. Crossref Member Badge Erfolgreich durch internationale Zusammenarbeit OBSTETRICS DOI 10.35630/2023/13/4.817 Received 11 July 2023; Accepted 19 July 2023, Published 15 August 2023 THE ROLE OF UTEROCERVICAL ANGLE IN DETERMINING THE THREAT OF PRETERM BIRTH Ufuk Atlıhan orcid id logo , Umit Derundere orcid id logo Private Karatas Hospital, Izmir, Turkey download article (pdf) cfl.ufuk@gmail.com ABSTRACT Preterm labor is one of the leading causes of perinatal morbidity and mortality and is thought to complicate approximately 10-12% of pregnancies. Defined as birth before 37 weeks of gestation, preterm labor is one of the most common obstetric complications worldwide. Although the pathogenesis of preterm labor is not fully understood, intraamniotic infection or hemorrhage, uteroplacental ischemia, uterine overstretching and immunologic processes have been proposed in its etiology. However, there is still no definitive prediction tool. Sonographic assessment of the cervical structure by measuring cervical length (CL) has been used as a popular prediction tool to predict preterm labor. The uterocervical angle (UCA) is defined as the angle between the lower anterior uterine segment and the endocervical canal. Recently, UCA has been proposed as an alternative to CL for predicting preterm labor. In recent years, several studies have investigated the potential impact of UCA for preterm labor prediction. Our study aimed to determine whether the uterocervical angle, a new ultrasonographic marker for predicting preterm labor, is associated with the risk of spontaneous preterm delivery. The present study included 186 singleton pregnant women who gave birth in our hospital between January 2018 and December 2022. The data of the included patients were retrospectively evaluated from the hospital database and patient files. Regarding the primary outcome of our study, we found that there was a statistically significant difference in UCA and cervical length between women who delivered spontaneously preterm and women who delivered at term (p<0.05). In the second trimester ultrasonography evaluation, the mean UCA was wider and the mean cervical length was shorter in the preterm group. Contrary to other studies in the literature, smoking and history of preterm delivery as risk factors were not included in our study. The exact reasons for some of the differences between our findings and the studies reported in the literature are not clear, but may be attributed to several factors. First, the patient type was heterogeneously selected in the cited studies. There are large differences in terms of sample size and studies that may be attributed to such heterogeneity. In conclusion, wider UCA and shorter cervical length in the second trimester are associated with spontaneous preterm delivery. Measurement of UCA is a re","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multiple pregnancies are an important topic of obstetrics as they are interesting and carry high risk. The increasing use of ultrasonography (USG) has made it possible to detect multiple pregnancies early. In the last 30 years, there has been a significant increase in the number of multiple pregnancies, especially in developed countries, with the increase in gestational age and the use of progressively developing assisted reproductive techniques (ART). Complications related to preterm birth and prematurity are observed with an increased frequency in these pregnancies. Therefore, multiple pregnancies constitute a process that should be monitored much more closely than singleton pregnancies due to many accompanying maternal and fetal complications. In this study, it was aimed to evaluate the maternal and fetal outcomes of multiple pregnancies with assisted reproductive techniques or spontaneous delivery in our clinic. Among all pregnant women who gave birth in our hospital between January 2018 and March 2022, 53 multiple pregnancies were included in the study. Maternal age, gestational week, delivery history, mode of delivery, birth weight and apgar scores (1st and 5th minutes) of the patients in the hospital database and file records were evaluated in terms of obstetric pathologies and perinatal outcomes. Level 1 and level 2 ultrasonography measurements and Doppler ultrasonography measurements of all patients were made by our radiology doctor in our hospital. Patient follow-ups were managed by the same gynecologist and obstetrician. There was no significant difference in the mean age of the participants according to birth weight, week of birth and mode of delivery (p>0.05). There was a significant difference in the mean age of the participants according to the presence of maternal hypertension (p<0.05). There was a statistically significant relationship between birth weight and multiple pregnancy status (p<0.05). The rate of birth weight of <1000 g and 1000-1500 g was higher in triplet pregnancies, and birth weight was found to be significantly lower than in twin pregnancies and this finding is consistent with the literature. There was a statistically significant relationship between the week of birth and multiple pregnancy status (p<0.05). The frequency of delivery between 24-28 and 28-32 weeks in triplet pregnancies was found to be significantly higher than in twin pregnancies and this finding is consistent with the literature. There was no statistically significant relationship between the presence of maternal Diabetes Mellitus (DM) and Hypertension (HT) and twin and triplet pregnancies (p>0.05). A statistically significant difference was found between twin pregnancy and triplet pregnancy in terms of both Apgar 1st Minute and Apgar 5th Minute scores (p<0.05). Both Apgar scores were higher in twin pregnancies. In a similar study, a high correlation and a statistically significant relationship was found between the 1st and 5th minute Apgar scores
{"title":"EVALUATION OF FETAL AND MATERNAL OUTCOMES IN MULTIPLE PREGNANCIES","authors":"Ufuk Atlıhan, Umit Derundere","doi":"10.35630/2023/13/4.816","DOIUrl":"https://doi.org/10.35630/2023/13/4.816","url":null,"abstract":"Multiple pregnancies are an important topic of obstetrics as they are interesting and carry high risk. The increasing use of ultrasonography (USG) has made it possible to detect multiple pregnancies early. In the last 30 years, there has been a significant increase in the number of multiple pregnancies, especially in developed countries, with the increase in gestational age and the use of progressively developing assisted reproductive techniques (ART). Complications related to preterm birth and prematurity are observed with an increased frequency in these pregnancies. Therefore, multiple pregnancies constitute a process that should be monitored much more closely than singleton pregnancies due to many accompanying maternal and fetal complications. In this study, it was aimed to evaluate the maternal and fetal outcomes of multiple pregnancies with assisted reproductive techniques or spontaneous delivery in our clinic. Among all pregnant women who gave birth in our hospital between January 2018 and March 2022, 53 multiple pregnancies were included in the study. Maternal age, gestational week, delivery history, mode of delivery, birth weight and apgar scores (1st and 5th minutes) of the patients in the hospital database and file records were evaluated in terms of obstetric pathologies and perinatal outcomes. Level 1 and level 2 ultrasonography measurements and Doppler ultrasonography measurements of all patients were made by our radiology doctor in our hospital. Patient follow-ups were managed by the same gynecologist and obstetrician. There was no significant difference in the mean age of the participants according to birth weight, week of birth and mode of delivery (p>0.05). There was a significant difference in the mean age of the participants according to the presence of maternal hypertension (p<0.05). There was a statistically significant relationship between birth weight and multiple pregnancy status (p<0.05). The rate of birth weight of <1000 g and 1000-1500 g was higher in triplet pregnancies, and birth weight was found to be significantly lower than in twin pregnancies and this finding is consistent with the literature. There was a statistically significant relationship between the week of birth and multiple pregnancy status (p<0.05). The frequency of delivery between 24-28 and 28-32 weeks in triplet pregnancies was found to be significantly higher than in twin pregnancies and this finding is consistent with the literature. There was no statistically significant relationship between the presence of maternal Diabetes Mellitus (DM) and Hypertension (HT) and twin and triplet pregnancies (p>0.05). A statistically significant difference was found between twin pregnancy and triplet pregnancy in terms of both Apgar 1st Minute and Apgar 5th Minute scores (p<0.05). Both Apgar scores were higher in twin pregnancies. In a similar study, a high correlation and a statistically significant relationship was found between the 1st and 5th minute Apgar scores","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Insufficient blood flow to the proximal femur causes osteonecrosis of the femoral head, which is known as femoral head avascular necrosis (AVN). The underlying pathogenesis is unclear, risk factors are likely to influence microcirculation somewhat, but this has not been confirmed by research. In more than 75% of cases, avascular necrosis affects the femoral head. Methods: From August 2019 to March 2022, 4 patients with FBAN were analyzed retrospectively. The findings seen in the hip MRI radiographs of the patients were reported radiologically as FBAN. It was staged with the Ficat and Arlet classifications. Visual analog scale (VAS) was used in the current clinics of the patients. Results: Patients with severe back, hip, and leg pain whose clinic and radiology do not match with lumbar pathology should plan a hip MRI. Because of this, it may be misleading for people with severe radiculopathy, and this radiculopathy may not even be real. The pain is really coming from the hip, but it is often felt in the lumbosacral region and the buttocks. This makes it easy to make the wrong diagnosis.
{"title":"A RARE CAUSE OF RADICULOPATHY: FEMORAL HEAD AVASCULAR NECROSIS","authors":"Ozgur Aksan, Mehmer Secer","doi":"10.35630/2023/13/4.815","DOIUrl":"https://doi.org/10.35630/2023/13/4.815","url":null,"abstract":"Insufficient blood flow to the proximal femur causes osteonecrosis of the femoral head, which is known as femoral head avascular necrosis (AVN). The underlying pathogenesis is unclear, risk factors are likely to influence microcirculation somewhat, but this has not been confirmed by research. In more than 75% of cases, avascular necrosis affects the femoral head. Methods: From August 2019 to March 2022, 4 patients with FBAN were analyzed retrospectively. The findings seen in the hip MRI radiographs of the patients were reported radiologically as FBAN. It was staged with the Ficat and Arlet classifications. Visual analog scale (VAS) was used in the current clinics of the patients. Results: Patients with severe back, hip, and leg pain whose clinic and radiology do not match with lumbar pathology should plan a hip MRI. Because of this, it may be misleading for people with severe radiculopathy, and this radiculopathy may not even be real. The pain is really coming from the hip, but it is often felt in the lumbosacral region and the buttocks. This makes it easy to make the wrong diagnosis.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Kalinin, E. Barinov, Sergey Dzhuvalyakov, O. Romanova
The article deals with the issues of regulation of practical activities related to the use of assisted reproductive technologies (ART). Currently, disputes about the quality and the results of in vitro fertilization, surrogacy and the use of other methods of infertility treatment are considered to be mainly in the realm of civil litigation. However, even the most high-tech medical devices are associated with a certain degree of risk to life and health. Cases of fatal outcomes among mothers or babies after the use of ART lead to the initiation of criminal cases against healthcare providers. At the same time, the forensic methodology of investigating such cases requires a commission forensic medical examination, the results of which become the major stumbling block at all stages of criminal proceedings. There are challenges in the organization and methodological support of the work of the investigation, the prosecutor's office and the courts. Especially, when several experts with opposite views clash in court over a case, where they completely or partially refute each other. In our paper we highlight an example of such a case to improve legislation and judicial practice in this area.
{"title":"THE ISSUE OF ADVERSE EFFECTS IN CASE OF VITRO FERTILIZATION","authors":"R. Kalinin, E. Barinov, Sergey Dzhuvalyakov, O. Romanova","doi":"10.35630/2023/13/4.805","DOIUrl":"https://doi.org/10.35630/2023/13/4.805","url":null,"abstract":"The article deals with the issues of regulation of practical activities related to the use of assisted reproductive technologies (ART). Currently, disputes about the quality and the results of in vitro fertilization, surrogacy and the use of other methods of infertility treatment are considered to be mainly in the realm of civil litigation. However, even the most high-tech medical devices are associated with a certain degree of risk to life and health. Cases of fatal outcomes among mothers or babies after the use of ART lead to the initiation of criminal cases against healthcare providers. At the same time, the forensic methodology of investigating such cases requires a commission forensic medical examination, the results of which become the major stumbling block at all stages of criminal proceedings. There are challenges in the organization and methodological support of the work of the investigation, the prosecutor's office and the courts. Especially, when several experts with opposite views clash in court over a case, where they completely or partially refute each other. In our paper we highlight an example of such a case to improve legislation and judicial practice in this area.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"1 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41353649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study is to investigate the effect of organic selenium and low doses of zinc on nickel intoxication. Selenium and zinc were administered once daily at a dose of 4 and 1 mg/ kg. Nickel chloride (5 mg/kg) was administered intragastrically using a probe, daily for one month. At the end of the experiment time (30 days), the main parameters of systemic hemodynamics were determined. The arterial blood pressure from the femoral artery was measured and the mean (MAP) was calculated. Cardiac output was determined by thermal dilution, heart rate (HR) was recorded; cardiac index, shock index and specific peripheral vascular resistance were calculated using special formulas. Our findings showed that nickel leads to significant disruptions in hemodynamics and heart function of rats, manifested in an increase in MAP, a change in heart rate, a decrease in systolic output. The introduction of selenium or small doses of zinc in rats exposed to nickel, produced a noticeable decrease in the cardiotoxic effects of this metal. There was also a decrease in the hypertensive effect of the metal. Thus, it has been established that antioxidants selenium and zinc can effectively reduce nickel toxicity.
{"title":"HEMODYNAMIC CHANGES IN NICKEL INTOXICATION AND THEIR EXPERIMENTAL CORRECTION WITH ORGANIC SELENIUM AND SMALL DOSES OF ZINC","authors":"David Oganesyan, V. Brin, O. Kabisov","doi":"10.35630/2023/13/4.810","DOIUrl":"https://doi.org/10.35630/2023/13/4.810","url":null,"abstract":"The purpose of the study is to investigate the effect of organic selenium and low doses of zinc on nickel intoxication. Selenium and zinc were administered once daily at a dose of 4 and 1 mg/ kg. Nickel chloride (5 mg/kg) was administered intragastrically using a probe, daily for one month. At the end of the experiment time (30 days), the main parameters of systemic hemodynamics were determined. The arterial blood pressure from the femoral artery was measured and the mean (MAP) was calculated. Cardiac output was determined by thermal dilution, heart rate (HR) was recorded; cardiac index, shock index and specific peripheral vascular resistance were calculated using special formulas. Our findings showed that nickel leads to significant disruptions in hemodynamics and heart function of rats, manifested in an increase in MAP, a change in heart rate, a decrease in systolic output. The introduction of selenium or small doses of zinc in rats exposed to nickel, produced a noticeable decrease in the cardiotoxic effects of this metal. There was also a decrease in the hypertensive effect of the metal. Thus, it has been established that antioxidants selenium and zinc can effectively reduce nickel toxicity.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48639836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The coronavirus pandemic, which has spread with monstrous rapidity, placed a huge "burden" on humanity. In the attempt to deal with the disease many efforts were directed in the course of unraveling the pathogenetic mechanisms contributing to its adverse complications. The increased frequency of new-onset hyperglycemia during COVID-19 illness gave reason to assume that the SARS-CoV-2 virus could damage the insulin-producing pancreatic beta (β) cells. This fact set a new a focus of research interest related to studying potential mechanisms, leading to hyperglycemia or diabetes mellitus (DM). Literature data indicate that Corona viruses can damage pancreatic β-cells by a direct or indirect mechanism and cause changes in insulin synthesis, secretion and sensitivity. Assessment of the metabolic status of pancreatic β-cells infected with the SARS-CoV-2 virus showed a predominance of the glycolytic metabolic pathway, which further contributed to the worsening of β-cell dysfunction. All these observations give reason to assume that SARS-CoV-2 induces specific morphological and functional changes in pancreatic β-cells, which in long term, would have an impact on the metabolic homeostasis of the individual with a potential risk of future development of DM. In this review, the possible mechanisms of pancreatic β-cell damage are discussed in details, searching the answer to the question of whether SARS-CoV-2 can cause diabetes.
{"title":"HYPERGLYCEMIA AND COVID-19 – TWO SIDES OF ONE COIN","authors":"V. Tsvetkova, K. Todorova","doi":"10.35630/2023/13/4.801","DOIUrl":"https://doi.org/10.35630/2023/13/4.801","url":null,"abstract":"The coronavirus pandemic, which has spread with monstrous rapidity, placed a huge \"burden\" on humanity. In the attempt to deal with the disease many efforts were directed in the course of unraveling the pathogenetic mechanisms contributing to its adverse complications. The increased frequency of new-onset hyperglycemia during COVID-19 illness gave reason to assume that the SARS-CoV-2 virus could damage the insulin-producing pancreatic beta (β) cells. This fact set a new a focus of research interest related to studying potential mechanisms, leading to hyperglycemia or diabetes mellitus (DM). Literature data indicate that Corona viruses can damage pancreatic β-cells by a direct or indirect mechanism and cause changes in insulin synthesis, secretion and sensitivity. Assessment of the metabolic status of pancreatic β-cells infected with the SARS-CoV-2 virus showed a predominance of the glycolytic metabolic pathway, which further contributed to the worsening of β-cell dysfunction. All these observations give reason to assume that SARS-CoV-2 induces specific morphological and functional changes in pancreatic β-cells, which in long term, would have an impact on the metabolic homeostasis of the individual with a potential risk of future development of DM. In this review, the possible mechanisms of pancreatic β-cell damage are discussed in details, searching the answer to the question of whether SARS-CoV-2 can cause diabetes.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46200523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liudmyla Konovalenko, Oleksandr Litus, Viktor Litus
The article discusses the main links of the pathogenesis of allergic contact dermatitis and gives the results of patch testing in patients who were examined to determine the etiological factors of the disease. Screening showed that nickel, cobalt, methylisothiazolinone, phenylenediamine, formaldehydes and fragrances are the most common etiological factors of ACD. Named haptens cause the absolute majority of positive reactions in the selected group of patients, and also cause the largest number of reactions of pronounced intensity. Patch testing is an informative and useful method for a balanced planning in ACD patients treatment strategy, because it reveals the etiological matrix of the pathological process occurrence in the skin.
{"title":"ALLERGIC CONTACT DERMATITIS: ETIOLOGICAL MATRIX","authors":"Liudmyla Konovalenko, Oleksandr Litus, Viktor Litus","doi":"10.35630/2023/13/4.819","DOIUrl":"https://doi.org/10.35630/2023/13/4.819","url":null,"abstract":"The article discusses the main links of the pathogenesis of allergic contact dermatitis and gives the results of patch testing in patients who were examined to determine the etiological factors of the disease. Screening showed that nickel, cobalt, methylisothiazolinone, phenylenediamine, formaldehydes and fragrances are the most common etiological factors of ACD. Named haptens cause the absolute majority of positive reactions in the selected group of patients, and also cause the largest number of reactions of pronounced intensity. Patch testing is an informative and useful method for a balanced planning in ACD patients treatment strategy, because it reveals the etiological matrix of the pathological process occurrence in the skin.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135571328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Chaulin, J. Grigoryeva, E. Smirnova, G. Suvorova, D. Duplyakov, V. Vankov
Hypothyroidism causes a number of histological changes in almost all tissues and cells of the body of a mammal, which is accompanied by numerous clinical and functional disorders. This is due to the multifaceted and multifunctional role of thyroid hormones (thyroxine and triiodothyronine) in the body of mammals. Striated cardiac muscle tissue and its main structural unit (contractile cardiomyocyte) is one of the most frequently involved tissues in the histopathological process in hypothyroidism. In addition, hypothyroidism can be considered as one of the main risk factors for the development of cardiovascular diseases (heart failure, coronary heart disease, cardiac arrhythmias), so the study of histopathological changes in cardiac muscle tissue is of great theoretical and practical importance. To date, there are no studies evaluating histopathological ultrastructural changes in contractile cardiomyocytes in certain forms of hypothyroidism, in particular in overt acquired primary hypothyroidism. The purpose of this study is to investigate the histopathological changes in the nucleus and contractile apparatus of cardiomyocytes in the conditions of experimental modeling of overt acquired primary hypothyroidism. Materials and Methods: male Chinchilla rabbits aged 12-14 months and weighing 3.1-3.5 kg (n=10), were divided into 2 equal groups. 1) The experimental group (n=5), where overt primary hypothyroidism was induced by oral administration of the antithyroid drug thiamazole (10 mg/kg for 4 weeks). 2) The animals of the control group (n=5) received placebo and were in a state of normothyroidism. Transmission electron microscopy (TEM) was used to study ultrastructural changes in contractile cardiomyocytes. Results and Conclusion: Based on the results of electron microscopic study, we detected numerous ultrastructural changes in the nucleus and contractile apparatus of cardiomyocytes: the nucleus (wrinkling, uneven contours of the nucleus and emergence of karyolemma invaginations, chromatin condensation); in the contractile apparatus (thinning of myofibrils, emergence of areas of myofibrils overcontraction with contractures). These ultrastructural changes in cardiomyocytes underlie the disruption of myocardial contractility, as well as an increase in dystrophic and apoptotic changes with the gradual development of heart failure, which is a frequent companion of untreated overt acquired primary hypothyroidism.
{"title":"HISTOPATHOLOGICAL CHANGES IN THE NUCLEUS AND CONTRACTILE APPARATUS OF CARDIOMYOCYTES IN OVERT ACQUIRED PRIMARY HYPOTHYROIDISM: EXPERIMENTAL STUDY","authors":"A. Chaulin, J. Grigoryeva, E. Smirnova, G. Suvorova, D. Duplyakov, V. Vankov","doi":"10.35630/2023/13/4.807","DOIUrl":"https://doi.org/10.35630/2023/13/4.807","url":null,"abstract":"Hypothyroidism causes a number of histological changes in almost all tissues and cells of the body of a mammal, which is accompanied by numerous clinical and functional disorders. This is due to the multifaceted and multifunctional role of thyroid hormones (thyroxine and triiodothyronine) in the body of mammals. Striated cardiac muscle tissue and its main structural unit (contractile cardiomyocyte) is one of the most frequently involved tissues in the histopathological process in hypothyroidism. In addition, hypothyroidism can be considered as one of the main risk factors for the development of cardiovascular diseases (heart failure, coronary heart disease, cardiac arrhythmias), so the study of histopathological changes in cardiac muscle tissue is of great theoretical and practical importance. To date, there are no studies evaluating histopathological ultrastructural changes in contractile cardiomyocytes in certain forms of hypothyroidism, in particular in overt acquired primary hypothyroidism. The purpose of this study is to investigate the histopathological changes in the nucleus and contractile apparatus of cardiomyocytes in the conditions of experimental modeling of overt acquired primary hypothyroidism. Materials and Methods: male Chinchilla rabbits aged 12-14 months and weighing 3.1-3.5 kg (n=10), were divided into 2 equal groups. 1) The experimental group (n=5), where overt primary hypothyroidism was induced by oral administration of the antithyroid drug thiamazole (10 mg/kg for 4 weeks). 2) The animals of the control group (n=5) received placebo and were in a state of normothyroidism. Transmission electron microscopy (TEM) was used to study ultrastructural changes in contractile cardiomyocytes. Results and Conclusion: Based on the results of electron microscopic study, we detected numerous ultrastructural changes in the nucleus and contractile apparatus of cardiomyocytes: the nucleus (wrinkling, uneven contours of the nucleus and emergence of karyolemma invaginations, chromatin condensation); in the contractile apparatus (thinning of myofibrils, emergence of areas of myofibrils overcontraction with contractures). These ultrastructural changes in cardiomyocytes underlie the disruption of myocardial contractility, as well as an increase in dystrophic and apoptotic changes with the gradual development of heart failure, which is a frequent companion of untreated overt acquired primary hypothyroidism.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43879789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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