A. Gorbunov, DMITRY PARSHIN, M. Kalugina, Zhanna Shishkina, Alexey Loktev, Svetlana Shirokova
Todd's paralysis is rare phenomenon, but its identification is of key diagnostic and therapeutic value. The authors present a clinical observation of post-traumatic encephalopathy accompanied by Todd's paralysis. The main differential diagnostic criteria for post-traumatic encephalopathy with cerebral paroxysms in the form of Todd's paralysis and stroke syndromes have been identified: closed craniocerebral injury in history; epileptiform paroxysms; a clear connection between epileptic seizures and trauma; characteristic "scarcity" of the clinical picture; stereotype paroxysms and rapid regression of symptoms; electroencephalographic study; absence of significant pathological changes on magnetic resonance tomo- and angiography; dissociation between the presence of a neurological deficit and magnetic resonance neuroimaging data; cumulated clinical analysis.
{"title":"POSTICTAL TODD’S PARALYSIS AS A MANIFESTATION OF POSTTRAUMATIC ENCEPHALOPATHY AND A “MASK” OF STROKE: CLINICAL OBSERVATION","authors":"A. Gorbunov, DMITRY PARSHIN, M. Kalugina, Zhanna Shishkina, Alexey Loktev, Svetlana Shirokova","doi":"10.35630/2023/13/1.209","DOIUrl":"https://doi.org/10.35630/2023/13/1.209","url":null,"abstract":"Todd's paralysis is rare phenomenon, but its identification is of key diagnostic and therapeutic value. The authors present a clinical observation of post-traumatic encephalopathy accompanied by Todd's paralysis. The main differential diagnostic criteria for post-traumatic encephalopathy with cerebral paroxysms in the form of Todd's paralysis and stroke syndromes have been identified: closed craniocerebral injury in history; epileptiform paroxysms; a clear connection between epileptic seizures and trauma; characteristic \"scarcity\" of the clinical picture; stereotype paroxysms and rapid regression of symptoms; electroencephalographic study; absence of significant pathological changes on magnetic resonance tomo- and angiography; dissociation between the presence of a neurological deficit and magnetic resonance neuroimaging data; cumulated clinical analysis.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48827320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ye. E. Chip, A. Kalashnikov, V. Protsenko, Oleksii Kalashnikov, Yurii Stavinsky, O. Pelypenko
Aim: To justify the choice of a method for fixing unstable proximal tibial fractures (PTF), to conduct computer simulation of stresses on various metal fixators. Materials and Methods: at the initial stage, a solid 3D model of the lower leg has been created using Solid Works, on the background of anatomical models and CT scans. The model contained the following elements: tibia and fibula, interosseous membrane, ligaments of the proximal and distal tibia syndesmosis, and a modeled proximal tibial fracture. We have subsequently studied 4 models of bone fragments’ fixation with LCP plates and an intramedullary blocking metal rod. Further calculations were performed using the finite element method. Results: computer simulations of stresses on various metal fixators applied to fix a PTF convincingly proved that blocked intramedullary osteosynthesis (BIOS) and LCP plates placed bilaterally are feasible for this category of patients. Conclusions: Deformities and loads observed in the metal fixator, bone tissue and ligamentous apparatus run within normal limits. They are statistically significantly (p ≤ 0.05) lower in models of bone fragments’ fixation with IM nailing and bilaterally placed LCP plates. This evidences the adequate stability of bone fragments’ and these methods of osteosynthesis as a whole, compared to the stains in the same elements of modelled fixation using only one plate – medially or laterally. The results of the study may serve as the background for the development of an algorithm for surgical treatment and rehabilitation of patients with PTF.
{"title":"BIOMECHANICAL SUBSTANTIATION OF THE CHOICE OF THE METHOD FOR FIXING UNSTABLE FRACTURES OF THE PROXIMAL TIBIA","authors":"Ye. E. Chip, A. Kalashnikov, V. Protsenko, Oleksii Kalashnikov, Yurii Stavinsky, O. Pelypenko","doi":"10.35630/2023/13/1.213","DOIUrl":"https://doi.org/10.35630/2023/13/1.213","url":null,"abstract":"Aim: To justify the choice of a method for fixing unstable proximal tibial fractures (PTF), to conduct computer simulation of stresses on various metal fixators. Materials and Methods: at the initial stage, a solid 3D model of the lower leg has been created using Solid Works, on the background of anatomical models and CT scans. The model contained the following elements: tibia and fibula, interosseous membrane, ligaments of the proximal and distal tibia syndesmosis, and a modeled proximal tibial fracture. We have subsequently studied 4 models of bone fragments’ fixation with LCP plates and an intramedullary blocking metal rod. Further calculations were performed using the finite element method. Results: computer simulations of stresses on various metal fixators applied to fix a PTF convincingly proved that blocked intramedullary osteosynthesis (BIOS) and LCP plates placed bilaterally are feasible for this category of patients. Conclusions: Deformities and loads observed in the metal fixator, bone tissue and ligamentous apparatus run within normal limits. They are statistically significantly (p ≤ 0.05) lower in models of bone fragments’ fixation with IM nailing and bilaterally placed LCP plates. This evidences the adequate stability of bone fragments’ and these methods of osteosynthesis as a whole, compared to the stains in the same elements of modelled fixation using only one plate – medially or laterally. The results of the study may serve as the background for the development of an algorithm for surgical treatment and rehabilitation of patients with PTF.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49224087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess dental health for quality of life, special dental tests are used that are designed to measure the frequency, degree of influence of dental problems on functional and socio-psychological well-being. The purpose of the study was to assess the impact of dental defects and concomitant periodontitis on the quality of life. A study of the quality of life of 65 patients was conducted. A survey conducted among patients with dental defects and concomitant periodontitis revealed a significant deterioration in the quality of life before treatment, compared with the same individuals after treatment.
{"title":"INFLUENCE OF DENTAL DEFECTS WITH ASSOCIATED PERIODONTITIS ON THE QUALITY OF LIFE","authors":"S. Averyanov, B. Yakupov, Ksenia Zavadich","doi":"10.35630/2023/13/1.217","DOIUrl":"https://doi.org/10.35630/2023/13/1.217","url":null,"abstract":"To assess dental health for quality of life, special dental tests are used that are designed to measure the frequency, degree of influence of dental problems on functional and socio-psychological well-being. The purpose of the study was to assess the impact of dental defects and concomitant periodontitis on the quality of life. A study of the quality of life of 65 patients was conducted. A survey conducted among patients with dental defects and concomitant periodontitis revealed a significant deterioration in the quality of life before treatment, compared with the same individuals after treatment.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46019021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: In recent years, studies of infrared laser irradiation effect on tumor cells in combination with various chemotherapeutic agents have been developing dynamically. Objective: To study the effect of infrared laser in combination with low doses of doxorubicin on cytomorphological characteristics of MCF-7DOX culture cells and p21 expression level. Materials and Methods: MCF-7DOX tumor cells were cultured in DMEM medium with 10% fetal calf serum (FCT) and 40 μg/ml gentamicin. Doxorubicin was added to the cells to a final concentration of 2 μg/ml and 0.5 μg/ml. Cells were irradiated with infrared laser (Fotonika-Plus, Ukraine) with a wavelength of 810 nm (irradiation time — 5 min, power density — 50 mV/cm², irradiation dose 15 J/cm²). Photomicrographs of cells were taken using a Carl Zeiss microscope, Germany. An immunocytochemical study was also conducted using monoclonal antibodies to the factor p21 (Thermo Scientific, USA). Results: The evaluation of morphological characteristics in micropreparations testifies to the antitumor effectiveness of the combined effect of infrared laser irradiation and doxorubicin. It is noteworthy that the cytotoxic effects of chemotherapy in combination with photobiomodulation were observed when using different doses of doxorubicin: 2 μg/ml and 0.5 μg/ml. When studying the biological activity of cells using immunocytochemistry, it was established that the combination of doxorubicin and infrared laser irradiation led to an increase in the expression of p21, and it is important to note that a similar effect was observed at both concentrations of doxorubicin: as at 2.0 μg/ ml and 0.5 μg/ml. The simultaneous destructive effect on tumor cells and the increase in p21 expression allows us to make a preliminary cautious assumption that the proposed technique of combination of infrared laser irradiation with doxorubicin determines the effect of the p21 factor in the role of a tumor suppressor. Conclusions: The results of the study allow us to consider the use of doxorubicin in combination with infrared laser as a promising method of cytotoxic effect on tumor cells.
{"title":"CYTOMORPHOLOGICAL CHANGES IN MCF7-DOX CELLS AND THEIR CORRELATION WITH THE ACTIVITY OF THE CELL CYCLE REGULATOR P21 AFTER COMBINED EXPOSURE TO INFRARED LASER AND DOXORUBICIN","authors":"S. Konovalenko, V. Protsenko","doi":"10.35630/2023/13/1.215","DOIUrl":"https://doi.org/10.35630/2023/13/1.215","url":null,"abstract":"Introduction: In recent years, studies of infrared laser irradiation effect on tumor cells in combination with various chemotherapeutic agents have been developing dynamically. Objective: To study the effect of infrared laser in combination with low doses of doxorubicin on cytomorphological characteristics of MCF-7DOX culture cells and p21 expression level. Materials and Methods: MCF-7DOX tumor cells were cultured in DMEM medium with 10% fetal calf serum (FCT) and 40 μg/ml gentamicin. Doxorubicin was added to the cells to a final concentration of 2 μg/ml and 0.5 μg/ml. Cells were irradiated with infrared laser (Fotonika-Plus, Ukraine) with a wavelength of 810 nm (irradiation time — 5 min, power density — 50 mV/cm², irradiation dose 15 J/cm²). Photomicrographs of cells were taken using a Carl Zeiss microscope, Germany. An immunocytochemical study was also conducted using monoclonal antibodies to the factor p21 (Thermo Scientific, USA). Results: The evaluation of morphological characteristics in micropreparations testifies to the antitumor effectiveness of the combined effect of infrared laser irradiation and doxorubicin. It is noteworthy that the cytotoxic effects of chemotherapy in combination with photobiomodulation were observed when using different doses of doxorubicin: 2 μg/ml and 0.5 μg/ml. When studying the biological activity of cells using immunocytochemistry, it was established that the combination of doxorubicin and infrared laser irradiation led to an increase in the expression of p21, and it is important to note that a similar effect was observed at both concentrations of doxorubicin: as at 2.0 μg/ ml and 0.5 μg/ml. The simultaneous destructive effect on tumor cells and the increase in p21 expression allows us to make a preliminary cautious assumption that the proposed technique of combination of infrared laser irradiation with doxorubicin determines the effect of the p21 factor in the role of a tumor suppressor. Conclusions: The results of the study allow us to consider the use of doxorubicin in combination with infrared laser as a promising method of cytotoxic effect on tumor cells.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46227598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sulima, Anatoliy N. Rybalka, Vyacheslav Mykhaylichenko, DMITRY PARSHIN
Purpose: This article describes the experience of using the Enhanced Recovery After Surgery (ERAS) program in the treatment of female patients with pelvioperitonitis in a gynecological in-patient department. Materials and Methods: We examined 60 female patients who were divided into the main and comparison groups. The groups were comparable in terms of age, marital status, education, and place of residence. In addition to the standard approaches in the treatment of pelvioperitonitis, 30 patients of the main group were treated using some elements of the concept of enhanced recovery, such as detailed preoperative counseling about future treatment, non-use of premedication, control of hypothermia during and after surgery, prevention of dyspeptic disorders in postoperative period, avoiding narcotic analgesics, early enteral nutrition and mobilization. In the comparison group, which also included 30 patients, the treatment of pelvioperitonitis was carried out in strict accordance with the standard scheme - surgery, balanced infusion therapy, symptomatic treatment. Results: At the same time, the pain level by the visual analogue scale (VAS) averaged 6.11 ± 0.34 after 2, 4 and 8 hours in women from the comparison group. Vomiting was registered in 3 (10.0%) patients from the main group on the day 1 of the postoperative period. Whereas 7 (23.3%) patients from the comparison group had vomiting on the day 1 of the postoperative period. The absence of active motility and passage of flatus, an increase in hypoproteinemia, hypoalbuminemia, and an increase in the level of leukocytosis in both groups showed the severity of the systemic inflammatory response. However, by the end of the day 2 of the postoperative period, the improvement in biochemical parameters was registered as a sign of a positive change in the patients’ general condition. LII decreased by 1.5 times by the day 5 in the comparison group; but in the main group it decreased by 2.3 times. First active peristaltic noises were auscultated and first passage of flatus were noted on average after 20.33 ± 1.02 hours in the main group, but in the comparison group - after 40.28 ± 0.81 hours. In addition to that, the need for pharmacological intestinal stimulation was 2.5 times higher in patients from the comparison group than in patients from the main group. Postoperative purulent inflammation of the wound was registered in 9 (30.0%) women from the control group. However, only 2 (6.7%) women from the main group had one of the above mentioned disorders. The absolute risk reduction is 15% and NNT = 7. The average hospital stay for patients from the main group was 6.15 ± 0.25 days, and 8.64 ± 0.38 days for women from the comparison group. Conclusion: The results obtained during the study prove the effectiveness of the concept of enhanced recovery in the treatment of pelvioperitonitis.
{"title":"EXPERIENCE OF USING ENHANCED POSTOPERATIVE RECOVERY PROGRAM IN THE TREATMENT OF PELVIOPERITONITIS","authors":"A. Sulima, Anatoliy N. Rybalka, Vyacheslav Mykhaylichenko, DMITRY PARSHIN","doi":"10.35630/2023/13/1.216","DOIUrl":"https://doi.org/10.35630/2023/13/1.216","url":null,"abstract":"Purpose: This article describes the experience of using the Enhanced Recovery After Surgery (ERAS) program in the treatment of female patients with pelvioperitonitis in a gynecological in-patient department. Materials and Methods: We examined 60 female patients who were divided into the main and comparison groups. The groups were comparable in terms of age, marital status, education, and place of residence. In addition to the standard approaches in the treatment of pelvioperitonitis, 30 patients of the main group were treated using some elements of the concept of enhanced recovery, such as detailed preoperative counseling about future treatment, non-use of premedication, control of hypothermia during and after surgery, prevention of dyspeptic disorders in postoperative period, avoiding narcotic analgesics, early enteral nutrition and mobilization. In the comparison group, which also included 30 patients, the treatment of pelvioperitonitis was carried out in strict accordance with the standard scheme - surgery, balanced infusion therapy, symptomatic treatment. Results: At the same time, the pain level by the visual analogue scale (VAS) averaged 6.11 ± 0.34 after 2, 4 and 8 hours in women from the comparison group. Vomiting was registered in 3 (10.0%) patients from the main group on the day 1 of the postoperative period. Whereas 7 (23.3%) patients from the comparison group had vomiting on the day 1 of the postoperative period. The absence of active motility and passage of flatus, an increase in hypoproteinemia, hypoalbuminemia, and an increase in the level of leukocytosis in both groups showed the severity of the systemic inflammatory response. However, by the end of the day 2 of the postoperative period, the improvement in biochemical parameters was registered as a sign of a positive change in the patients’ general condition. LII decreased by 1.5 times by the day 5 in the comparison group; but in the main group it decreased by 2.3 times. First active peristaltic noises were auscultated and first passage of flatus were noted on average after 20.33 ± 1.02 hours in the main group, but in the comparison group - after 40.28 ± 0.81 hours. In addition to that, the need for pharmacological intestinal stimulation was 2.5 times higher in patients from the comparison group than in patients from the main group. Postoperative purulent inflammation of the wound was registered in 9 (30.0%) women from the control group. However, only 2 (6.7%) women from the main group had one of the above mentioned disorders. The absolute risk reduction is 15% and NNT = 7. The average hospital stay for patients from the main group was 6.15 ± 0.25 days, and 8.64 ± 0.38 days for women from the comparison group. Conclusion: The results obtained during the study prove the effectiveness of the concept of enhanced recovery in the treatment of pelvioperitonitis.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48793685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Germanova, G. Galati, A. Voronin, K. Gorbunova, A. Germanov
Premature ventricular contractions (PVCs) are not included in the risk factors for arterial thromboembolism. Aim: To determine the relationship between PVCs and the development of arterial thromboembolic complications. Methods: The study included 440 patients with PVCs 700 or more per 24 hours, control group - 88 people with PVCs less than 700. All patients underwent laboratory and instrumental studies: lipid spectrum, hemostasis indicators; 24-hours ECG monitoring; echocardiography (EchoCG); Doppler ultrasound and digital sphygmography (SG) of the main arteries; ultrasound of the aorta branches, renal arteries. According to the indications - stress EchoCG with physical exercises, coronary angiography, pancerebral angiography, renal arteries angiography, computed tomography, magnetic resonance imaging of the brain. All patients of the main group were divided into 2 subgroups, depending on the moment of occurrence of PVCs ventricular systole in the cardiac cycle, regardless of the ectopic center: subgroup A (120) - patients with PVCs before the peak of transmitral blood flow; subgroup B (320) - after the peak of the transmitral blood flow. Patients were observed during 1 year and the development of arterial thromboembolic events was analyzed. Results: According to the main clinical, laboratory and instrumental data, patients of subgroups A, B and the control group were equivalent. Also, during 1 year, a statistically significantly higher development of arterial thromboembolic events was observed in subgroup A. When comparing linear blood flow velocity and volumetric blood flow, there was a significant increase in parameters during the spreading of the first post-extrasystolic contraction wave. A similar trend was observed in the parameters of the kinetics of the arterial vascular wall (velocity, acceleration, power, work). Conclusion: PVCs are an additional risk factor for arterial thromboembolic events. The main danger is not the PVC itself, but the wave of the first post-extrasystolic contraction, which can become the starting point for the instability of atherosclerotic plaques, leading to tears, parietal thrombosis, and embolism in the arterial vessels.
{"title":"PREMATURE VENTRICULAR CONTRACTIONS AS AN ADDITIONAL RISK FACTOR FOR THE ARTERIAL THROMBOEMBOLISM","authors":"O. Germanova, G. Galati, A. Voronin, K. Gorbunova, A. Germanov","doi":"10.35630/2023/13/1.201","DOIUrl":"https://doi.org/10.35630/2023/13/1.201","url":null,"abstract":"Premature ventricular contractions (PVCs) are not included in the risk factors for arterial thromboembolism. Aim: To determine the relationship between PVCs and the development of arterial thromboembolic complications. Methods: The study included 440 patients with PVCs 700 or more per 24 hours, control group - 88 people with PVCs less than 700. All patients underwent laboratory and instrumental studies: lipid spectrum, hemostasis indicators; 24-hours ECG monitoring; echocardiography (EchoCG); Doppler ultrasound and digital sphygmography (SG) of the main arteries; ultrasound of the aorta branches, renal arteries. According to the indications - stress EchoCG with physical exercises, coronary angiography, pancerebral angiography, renal arteries angiography, computed tomography, magnetic resonance imaging of the brain. All patients of the main group were divided into 2 subgroups, depending on the moment of occurrence of PVCs ventricular systole in the cardiac cycle, regardless of the ectopic center: subgroup A (120) - patients with PVCs before the peak of transmitral blood flow; subgroup B (320) - after the peak of the transmitral blood flow. Patients were observed during 1 year and the development of arterial thromboembolic events was analyzed. Results: According to the main clinical, laboratory and instrumental data, patients of subgroups A, B and the control group were equivalent. Also, during 1 year, a statistically significantly higher development of arterial thromboembolic events was observed in subgroup A. When comparing linear blood flow velocity and volumetric blood flow, there was a significant increase in parameters during the spreading of the first post-extrasystolic contraction wave. A similar trend was observed in the parameters of the kinetics of the arterial vascular wall (velocity, acceleration, power, work). Conclusion: PVCs are an additional risk factor for arterial thromboembolic events. The main danger is not the PVC itself, but the wave of the first post-extrasystolic contraction, which can become the starting point for the instability of atherosclerotic plaques, leading to tears, parietal thrombosis, and embolism in the arterial vessels.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44444992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aspergillosis is mainly a lung infection in human. This is caused by the fungus Aspergillus. Though, most of the strains are harmless to humans, only a few of them can cause serious diseases mostly in immunocompromised individuals. The individuals with a medical history of respiratory problems are at high risk of infection. An aspergillosis patient if not treated well within time it may result in invasive aspergillosis developing lung fibrosis, huge hemoptysis and multiple organ failures, CNS and brain infections, endocarditis and death. The present paper deals with their disease causing abilities, diagnosis and treatment in human in the light of recent researches done so far in the field of medical microbiology and pathology.
{"title":"ASPERGILLOSIS: THE DISEASE AT A GLANCE. REVIEW ARTICLE","authors":"M. Salim, N. Singh, M. Masroor, S. Parween","doi":"10.35630/2023/13/1.208","DOIUrl":"https://doi.org/10.35630/2023/13/1.208","url":null,"abstract":"Aspergillosis is mainly a lung infection in human. This is caused by the fungus Aspergillus. Though, most of the strains are harmless to humans, only a few of them can cause serious diseases mostly in immunocompromised individuals. The individuals with a medical history of respiratory problems are at high risk of infection. An aspergillosis patient if not treated well within time it may result in invasive aspergillosis developing lung fibrosis, huge hemoptysis and multiple organ failures, CNS and brain infections, endocarditis and death. The present paper deals with their disease causing abilities, diagnosis and treatment in human in the light of recent researches done so far in the field of medical microbiology and pathology.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44475942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vyacheslav Mykhaylichenko, Izmed Kaibov, DMITRY PARSHIN, L. Pritulo, O. Bezrukov
We examined 40 patients with neuropathic (group 1, n=20) and neuroischemic (group 2, n=20) diabetic foot. Before surgical treatment, we studied the content of cytokines (TNF-α, IFN-γ, IL-1β, IL-6 and IL-10) and eicosanoids (LTB4 and PGE2) in the exudate of the ulcer discharge. Pathogenetic mechanisms of inflammation disorders in patients with neuropathic and neuroischemic forms of diabetic foot are different. The neuropathic form is characterized by an increase in the level of TNF-α and IL-6 in the wound exudate, inhibition of the IL-1β and IL-10 secretion, and the predominance of LTB4 in contrast to inhibition of PGE2 synthesis. At the same time, the formation of CD8+ is inhibited as well as the switching of the neutrophilic phase to the macrophage phase by maintaining the conditions for the differentiation of M1 macrophages. In the neuroischemic form, we revealed hyperproduction of IL-1β, IL-10, IFN-γ, CD4+ with inhibition of IL-6 secretion and eicosanoids imbalance (PGE2 prevail over LTB4). This disrupts the differentiation of M2 macrophages. All identified disorders may be due to the persistence of various neutrophil phenotypes in the wound.
{"title":"INTERLEUKINS AND EICOSANOIDS: PATHOGENETIC PATTERNS OF DIABETIC FOOT ULCER","authors":"Vyacheslav Mykhaylichenko, Izmed Kaibov, DMITRY PARSHIN, L. Pritulo, O. Bezrukov","doi":"10.35630/2023/13/1.204","DOIUrl":"https://doi.org/10.35630/2023/13/1.204","url":null,"abstract":"We examined 40 patients with neuropathic (group 1, n=20) and neuroischemic (group 2, n=20) diabetic foot. Before surgical treatment, we studied the content of cytokines (TNF-α, IFN-γ, IL-1β, IL-6 and IL-10) and eicosanoids (LTB4 and PGE2) in the exudate of the ulcer discharge. Pathogenetic mechanisms of inflammation disorders in patients with neuropathic and neuroischemic forms of diabetic foot are different. The neuropathic form is characterized by an increase in the level of TNF-α and IL-6 in the wound exudate, inhibition of the IL-1β and IL-10 secretion, and the predominance of LTB4 in contrast to inhibition of PGE2 synthesis. At the same time, the formation of CD8+ is inhibited as well as the switching of the neutrophilic phase to the macrophage phase by maintaining the conditions for the differentiation of M1 macrophages. In the neuroischemic form, we revealed hyperproduction of IL-1β, IL-10, IFN-γ, CD4+ with inhibition of IL-6 secretion and eicosanoids imbalance (PGE2 prevail over LTB4). This disrupts the differentiation of M2 macrophages. All identified disorders may be due to the persistence of various neutrophil phenotypes in the wound.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45953408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadiya Yankova, Nikita Demchenkov, Alexandra Kosheleva, A. Morozov, Tatiana Sorokovikova, A. Morozova, S. Mgebrishvili, Anastasia Dorenskaya
BACKGROUND: Antibiotics have helped people to treat many diseases and have made the treatment of patients much easier. However, due to the development of resistance factors, antibiotics have become less effective against bacteria. Antimicrobial resistance is one of today's most important issues in global medicine. OBJECTIVE: to determine the expression of cephalosporin drug resistance in an inpatient setting. METHODS: This study was conducted at the Clinical Hospital of Emergency Medical Care Tver, Russia, for the period 2018-2020. Using the standard method of bacteriological examination, the microbiome of 624 patients was examined. The next step was to determine the level of antibiotic resistance. RESULTS: Microorganisms of different spectrum, including Pseudomonas aeruginosa, Escherichia coli, Acinetobacter, etc., were isolated from clinical samples during the study. All microorganism groups showed decreased susceptibility to the drugs used in the study. Ceftriaxone (a third-generation cephalosporin) had the greatest loss of potency (reduction to 0% for all isolates in the study). Cefoperazone sulbactam and ceftazidime rapidly lost activity in this study. Increasing resistance to cefepime (a fourth-generation cephalosporin) was observed. CONCLUSIONS. The study results indicate the rapid spread of resistance among a wide range of pathogenic microorganisms to the studied cephalosporin groups. Complete resistance developed within three years to the third-generation cephalosporins. A decrease in the susceptibility to the fourth generation of cephalosporins was observed.
{"title":"CEPHALOSPORIN ANTIBIOTIC RESISTANCE","authors":"Nadiya Yankova, Nikita Demchenkov, Alexandra Kosheleva, A. Morozov, Tatiana Sorokovikova, A. Morozova, S. Mgebrishvili, Anastasia Dorenskaya","doi":"10.35630/2023/13/1.207","DOIUrl":"https://doi.org/10.35630/2023/13/1.207","url":null,"abstract":"BACKGROUND: Antibiotics have helped people to treat many diseases and have made the treatment of patients much easier. However, due to the development of resistance factors, antibiotics have become less effective against bacteria. Antimicrobial resistance is one of today's most important issues in global medicine. OBJECTIVE: to determine the expression of cephalosporin drug resistance in an inpatient setting. METHODS: This study was conducted at the Clinical Hospital of Emergency Medical Care Tver, Russia, for the period 2018-2020. Using the standard method of bacteriological examination, the microbiome of 624 patients was examined. The next step was to determine the level of antibiotic resistance. RESULTS: Microorganisms of different spectrum, including Pseudomonas aeruginosa, Escherichia coli, Acinetobacter, etc., were isolated from clinical samples during the study. All microorganism groups showed decreased susceptibility to the drugs used in the study. Ceftriaxone (a third-generation cephalosporin) had the greatest loss of potency (reduction to 0% for all isolates in the study). Cefoperazone sulbactam and ceftazidime rapidly lost activity in this study. Increasing resistance to cefepime (a fourth-generation cephalosporin) was observed. CONCLUSIONS. The study results indicate the rapid spread of resistance among a wide range of pathogenic microorganisms to the studied cephalosporin groups. Complete resistance developed within three years to the third-generation cephalosporins. A decrease in the susceptibility to the fourth generation of cephalosporins was observed.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43783123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vyacheslav Mykhaylichenko, D. Voronkov, Enver Kеrimov, A. Butyrskii, DMITRY PARSHIN
The authors conducted a single-center clinical study of the effectiveness of endoscopic vacuum therapy for suture failure after bariatric surgery. The algorithm of actions was proposed, and the manipulations technique was described. Vacuum therapy was used in combination with a polyurethane obturator. The effectiveness of the technique was confirmed by positive results with the recovery of 8 patients. Endoscopic vacuum treatment of suture failure within the proposed algorithm is an effective method for treating the life-threatening complication of bariatric surgery.
{"title":"USING VACUUM-ASPIRATION SYSTEM FOR THE TREATMENT OF GIT SUTURE LEAKAGE IN BARIATRIC SURGERY","authors":"Vyacheslav Mykhaylichenko, D. Voronkov, Enver Kеrimov, A. Butyrskii, DMITRY PARSHIN","doi":"10.35630/2023/13/1.211","DOIUrl":"https://doi.org/10.35630/2023/13/1.211","url":null,"abstract":"The authors conducted a single-center clinical study of the effectiveness of endoscopic vacuum therapy for suture failure after bariatric surgery. The algorithm of actions was proposed, and the manipulations technique was described. Vacuum therapy was used in combination with a polyurethane obturator. The effectiveness of the technique was confirmed by positive results with the recovery of 8 patients. Endoscopic vacuum treatment of suture failure within the proposed algorithm is an effective method for treating the life-threatening complication of bariatric surgery.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44418449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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