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5G approach: Enhancing collaboration between primary care and specialist physicians 5G方法:加强初级保健和专科医生之间的合作
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-07-15 DOI: 10.1002/jgf2.70049
Kosuke Ishizuka MD, PhD, Taiju Miyagami MD, PhD, Yohei Kanzawa MD, Aiko Harada MD, Dai Aoki MD, Yoshiki Umezawa MD, Masataka Ono MD, So Sakamoto MD, PhD
<p>Effective collaboration between specialist and primary care physicians is essential for improving patient outcomes and ensuring appropriate medical resource use.<span><sup>1, 2</sup></span> However, their different perspectives can create barriers to care.<span><sup>1, 2</sup></span> Referral of patients from primary care to specialist physicians can result in gaps in diagnostic workup and treatment, leading to unnecessary tests or delays.<span><sup>2, 3</sup></span> Moreover, the lack of standards for consultation timing and information sharing contributes to misunderstandings. To address these issues, we—members of the Junior Doctors Association of the Japanese Society of Hospital General Medicine (JSHGM)—propose the “5G Approach,” (1. Gray Tolerance, 2. Guiding Criteria, 3. Gradual Transition, 4. Ground-Level Coordination, and 5. Growth Through Follow-up) five principles to promote effective collaboration between primary care and specialist physicians (Table 1). These principles were developed through a narrative literature review and discussions among eight primary care physicians with a median of 10 years' experience. The framework reflects clinical realities based on challenges from acute care settings and aligns with established concepts in the literature on collaborative care.<span><sup>4, 5</sup></span> It has been informally applied in case discussions to improve communication between primary care and specialist physicians.</p><p>In primary care, treatment plans are often made before confirming the diagnosis.<span><sup>4</sup></span> Primary care physicians must make decisions to mitigate risk while navigating uncertainty.<span><sup>4</sup></span> Specialist physicians, in turn, are expected to understand and respond appropriately to this uncertainty.<span><sup>1, 6</sup></span> However, discrepancies in perception may arise between the two regarding the degree of diagnostic certainty.<span><sup>6, 7</sup></span> To prevent this, primary care physicians must acknowledge and share diagnostic uncertainty with specialist physicians,<span><sup>6</sup></span> clearly communicating which aspects of the diagnosis are certain and which are uncertain, and specialist physicians should use this information to respond flexibly and manage time effectively.</p><p>To facilitate the transition from primary care to specialist care, the appropriate timing of consultations and the criteria for transfer need to be clarified.<span><sup>1, 2, 7</sup></span> In practice, lack of clarity can result in missed opportunities for timely interventions.<span><sup>1, 2, 7</sup></span> Thus, setting clear criteria for specialist consultation and patient transfer from primary to specialist care is necessary.<span><sup>1, 2, 7</sup></span> Moreover, even when the diagnosis is uncertain, sharing transfer criteria can streamline care, promote appropriate medical resource use, and optimize patient outcomes.<span><sup>1, 2, 7</sup></span></p><p>Depending on the patient's
专科医生和初级保健医生之间的有效协作对于改善患者预后和确保适当的医疗资源利用至关重要。1,2然而,他们的不同观点可能会造成护理障碍。1,2将患者从初级保健转到专科医生可能导致诊断检查和治疗方面的差距,从而导致不必要的检查或延误。2,3此外,缺乏咨询时间和信息共享的标准也会造成误解。为了解决这些问题,我们——日本医院综合医学学会(JSHGM)初级医生协会的成员——提出了“5G方法”(1)。灰色公差,2。3、指导标准;渐进过渡,4。4 .地面协调;通过随访促进成长)的五项原则,以促进初级保健和专科医生之间的有效合作(表1)。这些原则是通过对8位初级保健医生的叙述文献回顾和讨论制定的,他们的平均经验为10年。该框架反映了基于急性护理环境挑战的临床现实,并与文献中关于协作护理的既定概念保持一致。它已非正式地应用于病例讨论,以改善初级保健和专科医生之间的沟通。在初级保健中,治疗计划通常是在确诊之前制定的初级保健医生必须在应对不确定性的同时,做出降低风险的决定专科医生,反过来,被期望理解和适当应对这种不确定性。然而,在诊断的确定性程度上,两者之间的感知可能存在差异。为了防止这种情况,初级保健医生必须承认并与专科医生分享诊断的不确定性,6清楚地沟通诊断的哪些方面是确定的,哪些是不确定的,专科医生应该利用这些信息灵活地做出反应,有效地管理时间。为了促进从初级保健向专科保健的过渡,需要明确适当的咨询时间和转诊标准。1,2,7在实践中,缺乏明确性可能导致错失及时干预的机会。因此,为专科会诊和病人从初级护理转到专科护理制定明确的标准是必要的。此外,即使在诊断不确定的情况下,共享转诊标准也可以简化护理,促进适当的医疗资源利用,并优化患者的预后。根据病人的情况,从初级护理逐渐转移到专科护理可能是可取的在根据一天中的时间(白天、夜间、工作日和节假日)调整方法时,灵活性也至关重要,2,7和医疗资源的可用性,包括测试设备和医疗人员,需要考虑,特别是在夜间和节假日,使用预先确定的标准。加强初级保健和专科医生之间的直接沟通和建立相互信任对加强合作至关重要。1,2面对面分享患者信息和讨论治疗方案有助于防止误解和患者管理不一致。1,2在初级保健中,对治疗选择的反思往往不够充分。然而,咨询后适当的反馈可以使初级保健和专科医生提高护理质量,增强临床判断,积累知识此外,跟踪患者结果和审查治疗的适当性可以将见解应用于未来的护理,促进更好的决策和改善护理过程。应用构成“5G方法”的这五项原则可以促进初级保健和专科医生之间的合作,提高患者护理质量。需要确定合作方面的其他挑战,并需要宣传成功干预措施的案例研究。石冢浩介:写作-原稿;概念化;可视化。宫崎骏:写作-评论和编辑。Kanzawa洋平:写作-评论和编辑。原田爱子:写作-评论和编辑。戴青木:写作-评论和编辑。梅泽义树:写作-评论和编辑。小野正孝:写作——评论和编辑。所以坂本:写作-审查和编辑;概念化;可视化;监督。作者声明他们没有利益冲突。
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引用次数: 0
Core competencies of rural practice for medical students of government-sponsored medical education programs in Taiwan: The students' perspective
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-07-14 DOI: 10.1002/jgf2.70045
Shih-Ming Li PhD, Hang-Rui Zhang MS, Hsin-Yun Chang MD, Cheng-Loong Liang MD, PhD, Wang-Huei Sheng MD, PhD, Tsung-Ying Chen MD, Wen-Yuan Lin MD, PhD, Zih-Jie Sun MD, MS, Jin-Shang Wu MD, MS

Background

The shortage of rural physicians remains a public health concern. Placing medical students in rural areas and exposing them to rural physicians as models may enhance physician retention in rural areas. The purpose of this study was to explore the core competencies of medical students for rural practice and develop a framework of such competencies.

Methods

A three-stage mixed method was used to develop the core competencies of medical students who will engage in rural practice. In the exploring stage, four physicians completed in-depth interviews; eight students participated in the focus group to identify the core competencies. In the construct stage, two students were interviewed individually and four students as a group to construct the framework. Finally, the competencies were validated by experts in the verification stage. In addition, the analytic hierarchy process was used.

Results

After thematic analysis, three themes—adaptation, befriending, and career—emerged as the ABC model for rural practice. The framework of competencies for rural practice was established with the ABC model and validated by the analytic hierarchy process (AHP).

Conclusions

Although some competencies vary across professional stages, the ABC model—adaptation, befriending, and career—is the competencies essential for medical students preparing to practice in rural areas.

农村医生短缺仍然是一个令人关注的公共卫生问题。将医学生安置在农村地区,让他们作为榜样接触农村医生,可以提高农村地区医生的留存率。摘要本研究旨在探讨医学生乡村实习的核心能力,并建立医学生乡村实习的核心能力架构。方法采用三阶段混合法培养医学生农村实习的核心能力。在探索阶段,4位医生完成了深度访谈;8名学生参加了焦点小组,以确定核心能力。在构建阶段,分别对两名学生进行单独访谈,四名学生进行小组访谈,构建框架。最后,在验证阶段由专家对胜任力进行验证。此外,还采用了层次分析法。结果通过主题分析,发现适应、交友和职业三个主题是农村实践的ABC模式。运用ABC模型构建农村实践胜任力框架,并用层次分析法(AHP)进行验证。结论:尽管在不同的专业阶段,一些能力有所不同,但ABC模式——适应、交友和职业——是准备在农村地区实习的医学生所必需的能力。
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引用次数: 0
Varicella pneumonia associated with incomplete vaccination in a patient with trisomy 21: A case report 21三体患者与不完全疫苗接种相关的水痘肺炎1例报告
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-07-01 DOI: 10.1002/jgf2.70044
Satoshi Inaba MD, Sonoko Matsuyama MD, Hisatoshi Okumura MD, Atsushi Kawashima MD

Varicella pneumonia is a rare but severe complication of varicella-zoster infection in adults. We present what is, to our knowledge, the first documented case of a 24-year-old woman with trisomy 21 who developed disseminated varicella and varicella pneumonia, likely exacerbated by the absence of childhood varicella vaccination. Her social background, including single-parent upbringing and childhood relocation, contributed to her incomplete immunization history. This case highlights the convergence of immunological and social vulnerability and underscores the need for comprehensive vaccination assessments in adults with complex medical and social histories to prevent severe infectious diseases.

水痘肺炎是成人水痘带状疱疹感染的一种罕见但严重的并发症。据我们所知,我们报告了第一例记录在案的24岁21三体女性,她发展为播散性水痘和水痘肺炎,可能由于缺乏儿童水痘疫苗而加剧。她的社会背景,包括单亲抚养和童年迁移,导致她的免疫史不完整。该病例突出了免疫和社会脆弱性的一致性,并强调需要对具有复杂医疗和社会历史的成年人进行全面的疫苗接种评估,以预防严重传染病。
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引用次数: 0
Association between polypharmacy and the risk of requiring long-term care among community-dwelling older residents: A retrospective cohort study 社区居住的老年居民服用多种药物与需要长期护理的风险之间的关系:一项回顾性队列研究
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-30 DOI: 10.1002/jgf2.70041
Kengo Maeda MD, Shin-Ya Kawashiri MD, PhD, Kazuhiko Arima MD, PhD, Tetsuro Niri MD, PhD, Yukiko Honda MPH, DrPH, Jun Miyata MD, PhD, Fumiaki Nonaka MD, PhD, Hirokazu Kumazaki MD, PhD, Takahiro Maeda MD, PhD, Yasuhiro Nagata MD, PhD

Background

Polypharmacy has been increasing attention as it is associated with a number of health problems, especially adverse outcomes in older adults. However, there is insufficient evidence regarding the risk of polypharmacy and long-term care.

Methods

We analyzed a community-based retrospective cohort of residents of Goto City by combining data from health checkups, prescription information, and long-term care needs certification database. The study sample included residents aged 65–79 years in 2015 who were followed up for 4 years. The number of medications used was categorized as 0, 1–5, 6–9, and ≥10. The outcome was initiation of long-term care. Cox regression models were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for potential confounders.

Results

Among 1083 participants, 58 used long-term care for 4 years. Compared with participants taking no medication, the incidence of long-term care initiation was approximately double in those taking 1–5 medications, four times higher in people taking 6–9 medications, and 13 times higher in people taking ≥10 medications. After adjusting for potential baseline confounders, the number of medications was significantly associated with the initiation of long-term care services (1–5 drugs: adjusted HR 2.38, 95% CI 1.06–5.34; 6–9 drugs: adjusted HR 2.97, 95% CI 1.23–7.15; and ≥10 drugs: adjusted HR 5.54, 95% CI 1.89–16.23).

Conclusions

Among community-dwelling residents aged 65–79 years, the risk of requiring long-term care had a dose–response relationship with the number of prescribed medications.

背景:多种用药已引起越来越多的关注,因为它与许多健康问题有关,尤其是老年人的不良后果。然而,关于多种用药和长期护理的风险证据不足。方法结合健康检查、处方信息和长期护理需求认证数据库的数据,对后藤市以社区为基础的回顾性队列进行分析。研究样本包括2015年65-79岁的居民,随访4年。使用的药物数量分为0、1-5、6-9和≥10种。结果是长期护理的开始。采用Cox回归模型计算风险比(hr), 95%置信区间(ci)对潜在混杂因素进行调整。结果1083例患者中,58例接受了4年的长期护理。与不服用药物的参与者相比,服用1-5种药物的参与者开始长期护理的发生率大约是两倍,服用6-9种药物的参与者高4倍,服用≥10种药物的参与者高13倍。在调整了潜在的基线混杂因素后,药物的数量与长期护理服务的开始显著相关(1-5种药物:调整HR 2.38, 95% CI 1.06-5.34; 6-9种药物:调整HR 2.97, 95% CI 1.23-7.15;≥10种药物:调整HR 5.54, 95% CI 1.89-16.23)。结论在65 ~ 79岁的社区居民中,需要长期护理的风险与处方药物的数量呈剂量-反应关系。
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引用次数: 0
The clinical roles of generalists in Japan: A descriptive model of problem setting and problem-solving 日本多面手的临床角色:问题设定和问题解决的描述性模型
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-30 DOI: 10.1002/jgf2.70043
Masayuki Amano MD, MBA, Takashi Watari MD, MHQS, PhD, Taro Shimizu MD, MSc, MPH, MBA, PhD

“What do generalists do in clinical practice?” Students and specialists often ask this question. Although the identity of generalists in Japan is steadily forming, their specific roles in clinical practice remain unclear.

This ambiguity stems largely from the diverse nature of generalist practice in Japan. Generalists engage in a wide range of activities, including clinical practice, medical education, research, and management; in a range of settings including hospitals, clinics, and home care; in both urban and rural areas.1 Although this diversity is a strength, descriptions often emphasize differences rather than commonalities. Consequently, what generalists do in practice remains unclear.

This situation creates two important problems. For students, it can foster uncertainty about choosing a career as a generalist. For specialists, it can lead to confusion about when and how to collaborate with generalists, potentially hindering effective teamwork.

To address these challenges, we developed a model to clarify the common clinical roles of generalists (Figure 1). This editorial introduces the key aspects of the generalist's work in practice, focusing on the two fundamental processes of “problem setting” and “problem-solving”.2

Generalists fundamentally differ from specialists in their initial approach to patient care. Whereas specialists typically begin with a defined problem and apply evidence-based strategies to engage in “problem-solving,” generalists must first engage in “problem setting.” This is a complex process that involves identifying, prioritizing, and framing the patient's problems within their unique context before proceeding with problem-solving. Although specialists may appear to engage in problem setting during diagnosis, their main role is to assess whether managing the problem falls within the scope of their specialty; thus, their first step is problem-solving, not problem setting.

The process of problem setting starts with collecting a range of information extending beyond biomedical data from history taking, physical examination, and diagnostic tests, to include contextual factors such as daily life, the patient's health resources, biographical narratives, preferences, values, and life goals. The generalist then analyzes the interrelationships among these elements and works collaboratively with the patient to develop a shared understanding of the situation as a whole. Based on this holistic understanding, the healthcare team formulates a care strategy focusing on the most important health problem.

Problem-setting skills have become a focus of academic inquiry within the fields of generalism and diagnostic excellence. “Patient-centered medicine” stresses the importance of problem definition and proposes practical clinical methods.3 Furthermore, the “Craft of Generalism” highlights the role of interpretive

“通才在临床实践中做什么? ”学生和专家经常问这个问题。虽然在日本,通才的身份正在稳步形成,但他们在临床实践中的具体角色仍不清楚。这种歧义很大程度上源于日本通才实践的多样性。通才从事广泛的活动,包括临床实践、医学教育、研究和管理;在包括医院、诊所和家庭护理在内的一系列环境中;在城市和农村地区尽管这种多样性是一种优势,但描述往往强调差异而不是共性。因此,通才在实践中做什么仍然不清楚。这种情况产生了两个重要问题。对于学生来说,这可能会增加他们选择多面手职业的不确定性。对于专家来说,这可能会导致何时以及如何与通才合作的困惑,从而潜在地阻碍有效的团队合作。为了应对这些挑战,我们开发了一个模型来阐明通才的常见临床角色(图1)。这篇社论介绍了通才在实践中工作的关键方面,重点是“问题设置”和“解决问题”两个基本过程通才在病人护理的初始方法上与专科医生有着根本的不同。专家通常从一个明确的问题开始,并应用基于证据的策略来参与“解决问题”,而通才必须首先参与“问题设置”。这是一个复杂的过程,包括在解决问题之前,在患者的独特环境中识别、优先排序和构建问题。虽然专家可能在诊断过程中参与问题设置,但他们的主要作用是评估管理问题是否属于他们的专业范围;因此,他们的第一步是解决问题,而不是设置问题。问题设置的过程从收集一系列信息开始,这些信息不仅包括从病史、体检和诊断测试中获得的生物医学数据,还包括诸如日常生活、患者健康资源、传记叙述、偏好、价值观和生活目标等背景因素。通才然后分析这些因素之间的相互关系,并与患者合作,形成对整个情况的共同理解。基于这种全面的理解,医疗团队制定了一个关注最重要健康问题的护理策略。问题设置技能已经成为通才和卓越诊断领域学术研究的焦点。“以病人为中心的医学”强调问题界定的重要性,提出切实可行的临床方法此外,“通论的技巧”强调了解释性对话的作用,并提供了一个框架,用于整合不同的方法,如还原论和建构主义,以发展对患者环境的整体理解利用这些概念模型支持问题解决技能的进步,突出了结构化的、有理论依据的方法在通才实践中的关键作用。在这四个领域中,前三个领域构成了通才实践的核心领域。虽然每个领域都需要专门的知识和方法,但通才通过结构化的培训逐步发展这些技能。在临床环境中,许多病例跨越多个领域。随着重叠的增加,复杂性也在增加,需要有经验的全科医生的专业知识,并突出了在全科医学中持续学习和专业发展的重要性。想象一下,一位多面手在诊所看到一位中年妇女血压升高。这种方法从问题设置开始。综合评估显示患者需要对继发性高血压进行诊断性检查。通过解释性对话,通才了解患者个人病史中血压升高的重要性:她失去了一位家庭成员,患有高血压相关疾病,因此非常担心自己的血压。基于这种结构化的理解,如果血压升高被确定为高优先级的健康问题,通才就会进入解决问题的阶段。最初,血压升高将被视为一个普遍的健康问题。如果病因确定为原发性高血压,如有必要,将在普遍健康问题范围内考虑改变生活方式、支持应对压力和药物治疗。如果病因不明,该病例可能属于普遍健康问题和不确定条件重叠的领域。当多种复杂的合并症和/或不利的社会条件(如经济困难或农村生活)存在时,这种情况可能跨越所有三个核心领域。 如果病情难以控制,患者可转诊至二级或三级护理中心的另一位全科医生。如果需要专科护理,如对潜在的条件,如嗜铬细胞瘤,病人被转介到适当的专科,显示整体转诊。在所有这些情况下,通才的专业知识都是以一种持续的方式应用的。“日本的多面手在临床实践中是怎么做的?”我们通过提出一个模型来回答这个问题,在这个模型中,通才将他们的专业知识应用于问题设置和问题解决,通过这两种方法之间的动态转换不断优化护理。这种对通才工作的描述,通过描述问题设置的过程,解决问题的四个领域,以及它们之间的相互作用,有几个重要的含义。首先,通过提供对该职业更清晰的理解,它可以减少学生和年轻医生在考虑从事全才职业时的犹豫。其次,它可以通过明确定义通才专业知识的范围和性质来促进与专家的合作,从而促进更有效的跨学科团队合作。最后,这种模式的多功能性超越了临床护理,并有可能应用于其他领域,如医院管理和社区卫生,促进提供更全面的护理。天野雅之领导了这项工作的各个方面,包括概念化、方法论、调查、撰写原稿和项目管理。Takashi Watari支持和监督工作的各个方面,包括在整个研究和写作过程中提供指导。Taro Shimizu对概念化做出了贡献,并支持对手稿的修订。Takashi Watari是《普通与家庭医学杂志》的编辑委员会成员,也是本文的合著者。为了尽量减少偏倚,他们被排除在与接受这篇文章发表有关的所有编辑决策之外。所有作者均已同意发表。
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引用次数: 0
Bilateral primary adrenal lymphoma 双侧原发性肾上腺淋巴瘤
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-26 DOI: 10.1002/jgf2.70042
Rio Shimizu MD, Shogo Shirota MD
<p>A previously healthy 83-year-old woman was admitted to our hospital with a three-week history of fever and a one-day history of lower back pain. On physical examination, her body temperature was 38.9°C, blood pressure was 100/61 mmHg, and pulse rate was 112 beats/min. Palpable masses in the bilateral costal areas and bilateral costovertebral angle tenderness to percussion were noted. Laboratory tests revealed an elevated white blood cell count of 10,470/μL, lactate dehydrogenase level of 603 U/L, C-reactive protein of 15.64 mg/dL, and soluble interleukin-2 receptor of 2403 U/mL. Cortisol level was 4.57 μg/dL, and adrenocorticotropic hormone was 549.0 pg/mL. Adrenocorticotropic hormone stimulation test revealed a peak cortisol level of 4.99 μg/dL. Abdominal contrast-enhanced computed tomography (CT) demonstrated bilateral adrenal enlargement with heterogeneous enhancement (Figure 1). The right and left adrenal glands were 7 and 6 cm long, respectively. CT-guided biopsy of the right adrenal mass revealed proliferation of atypical cells with a high nuclear-to-cytoplasmic ratio on hematoxylin and eosin staining. Immunohistochemical staining revealed CD20 and Bcl-6 positivity, consistent with diffuse large B-cell lymphoma (Figure 2A,B). Based on these findings, the patient was diagnosed with bilateral primary adrenal lymphoma and primary adrenal insufficiency. She was treated with hydrocortisone at a dose of 20–30 mg per day, adjusted according to her clinical condition, and subsequently started on chemotherapy with rituximab, cyclophosphamide, doxorubicin, etoposide, and prednisone, but died on the 117th hospital day.</p><p>Primary adrenal lymphoma (PAL) is a rare lymphoma that accounts for approximately 1% of all malignant lymphomas, of which 80% are bilateral.<span><sup>1, 2</sup></span> PAL is characterized by its large size (>5 cm) but lacks specific imaging features distinguishing it from other adrenal malignancies.<span><sup>2, 3</sup></span> Other differential diagnoses of bilateral adrenal masses include pheochromocytoma, tuberculosis, or metastases. The average size of PAL masses has been reported to be 5.5 cm, while other bilateral adrenal masses are generally smaller, often less than 5 cm.<span><sup>4</sup></span> In addition, in cases of bilateral adrenal masses, adrenal insufficiency has been reported in 57% of PAL and 94% of tuberculosis and is less common in pheochromocytoma and metastasis.<span><sup>4</sup></span> If bilateral adrenal masses >5 cm are found in a patient with fever and back pain, it is important to consider PAL, evaluate adrenal function, and perform biopsy promptly.</p><p><b>Rio Shimizu:</b> Writing – original draft; data curation; investigation. <b>Shogo Shirota:</b> Writing – review and editing; conceptualization; supervision; project administration.</p><p>This study did not receive any specific grants from agencies in the public, commercial, or non-profit sectors.</p><p>The authors declare that they have n
一名先前健康的83岁妇女因三周的发热史和一天的腰痛史入住我院。查体体温38.9℃,血压100/61 mmHg,脉搏112次/min。双侧肋区可触及肿块,双侧肋椎角触痛。实验室检查显示白细胞计数升高10,470/μL,乳酸脱氢酶升高603 U/L, c反应蛋白升高15.64 mg/dL,可溶性白介素-2受体升高2403 U/mL。皮质醇4.57 μg/dL,促肾上腺皮质激素549.0 pg/mL。促肾上腺皮质激素刺激试验显示皮质醇峰值为4.99 μg/dL。腹部增强计算机断层扫描(CT)显示双侧肾上腺肿大伴非均匀增强(图1)。右肾上腺长7 cm,左肾上腺长6 cm。ct引导下的右侧肾上腺肿块活检显示苏木精和伊红染色显示核质比高的非典型细胞增生。免疫组化染色显示CD20和Bcl-6阳性,与弥漫性大B细胞淋巴瘤一致(图2A,B)。基于这些发现,患者被诊断为双侧原发性肾上腺淋巴瘤和原发性肾上腺功能不全。患者接受氢化可的松治疗,剂量为20 - 30mg /天,根据其临床情况进行调整,随后开始使用利妥昔单抗、环磷酰胺、阿霉素、依托泊苷和强的松化疗,但在第117天死亡。原发性肾上腺淋巴瘤(PAL)是一种罕见的淋巴瘤,约占所有恶性淋巴瘤的1%,其中80%发生在双侧。1,2 PAL的特点是体积大(约5cm),但缺乏与其他肾上腺恶性肿瘤区分的特异性影像学特征。其他双侧肾上腺肿块的鉴别诊断包括嗜铬细胞瘤、结核或转移瘤。PAL肿块的平均大小为5.5 cm,而其他双侧肾上腺肿块通常较小,通常小于5 cm此外,在双侧肾上腺肿物的病例中,肾上腺功能不全在57%的PAL和94%的结核病中被报道,而在嗜铬细胞瘤和转移中较少见如果在发烧和背部疼痛的患者中发现双侧肾上腺肿物(5cm),重要的是考虑PAL,评估肾上腺功能,并及时进行活检。里约热内卢清水:写作-原稿;数据管理;调查。Shogo Shirota:写作-评论和编辑;概念化;监督;项目管理。这项研究没有从公共、商业或非营利部门的机构获得任何具体的资助。作者宣称他们没有竞争利益。伦理批准声明:根据我们机构的政策,本病例报告不需要伦理批准。患者同意声明:患者在去世前就其医疗数据和相关图像的发表提供了书面知情同意。临床试验注册:无。本病例报告未使用以往发表的材料。患者在去世前提供了书面知情同意,以便公布其医疗数据和相关图像。
{"title":"Bilateral primary adrenal lymphoma","authors":"Rio Shimizu MD,&nbsp;Shogo Shirota MD","doi":"10.1002/jgf2.70042","DOIUrl":"https://doi.org/10.1002/jgf2.70042","url":null,"abstract":"&lt;p&gt;A previously healthy 83-year-old woman was admitted to our hospital with a three-week history of fever and a one-day history of lower back pain. On physical examination, her body temperature was 38.9°C, blood pressure was 100/61 mmHg, and pulse rate was 112 beats/min. Palpable masses in the bilateral costal areas and bilateral costovertebral angle tenderness to percussion were noted. Laboratory tests revealed an elevated white blood cell count of 10,470/μL, lactate dehydrogenase level of 603 U/L, C-reactive protein of 15.64 mg/dL, and soluble interleukin-2 receptor of 2403 U/mL. Cortisol level was 4.57 μg/dL, and adrenocorticotropic hormone was 549.0 pg/mL. Adrenocorticotropic hormone stimulation test revealed a peak cortisol level of 4.99 μg/dL. Abdominal contrast-enhanced computed tomography (CT) demonstrated bilateral adrenal enlargement with heterogeneous enhancement (Figure 1). The right and left adrenal glands were 7 and 6 cm long, respectively. CT-guided biopsy of the right adrenal mass revealed proliferation of atypical cells with a high nuclear-to-cytoplasmic ratio on hematoxylin and eosin staining. Immunohistochemical staining revealed CD20 and Bcl-6 positivity, consistent with diffuse large B-cell lymphoma (Figure 2A,B). Based on these findings, the patient was diagnosed with bilateral primary adrenal lymphoma and primary adrenal insufficiency. She was treated with hydrocortisone at a dose of 20–30 mg per day, adjusted according to her clinical condition, and subsequently started on chemotherapy with rituximab, cyclophosphamide, doxorubicin, etoposide, and prednisone, but died on the 117th hospital day.&lt;/p&gt;&lt;p&gt;Primary adrenal lymphoma (PAL) is a rare lymphoma that accounts for approximately 1% of all malignant lymphomas, of which 80% are bilateral.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; PAL is characterized by its large size (&gt;5 cm) but lacks specific imaging features distinguishing it from other adrenal malignancies.&lt;span&gt;&lt;sup&gt;2, 3&lt;/sup&gt;&lt;/span&gt; Other differential diagnoses of bilateral adrenal masses include pheochromocytoma, tuberculosis, or metastases. The average size of PAL masses has been reported to be 5.5 cm, while other bilateral adrenal masses are generally smaller, often less than 5 cm.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; In addition, in cases of bilateral adrenal masses, adrenal insufficiency has been reported in 57% of PAL and 94% of tuberculosis and is less common in pheochromocytoma and metastasis.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; If bilateral adrenal masses &gt;5 cm are found in a patient with fever and back pain, it is important to consider PAL, evaluate adrenal function, and perform biopsy promptly.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Rio Shimizu:&lt;/b&gt; Writing – original draft; data curation; investigation. &lt;b&gt;Shogo Shirota:&lt;/b&gt; Writing – review and editing; conceptualization; supervision; project administration.&lt;/p&gt;&lt;p&gt;This study did not receive any specific grants from agencies in the public, commercial, or non-profit sectors.&lt;/p&gt;&lt;p&gt;The authors declare that they have n","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 5","pages":"493-494"},"PeriodicalIF":2.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient experience in community pharmacy services: A scoping review 社区药房服务的患者体验:范围综述
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-24 DOI: 10.1002/jgf2.70040
Chiho Kaneko, Shota Suzuki MPH, Ibuki Tanaka, Haruna Hiruma, Hiroshi Okada PhD

Background

The role of pharmacists in community settings is expanding, and understanding patient experience– an essential indicator of person-centered care–is crucial for improving pharmacy service quality. However, the extent to which patient experience has been studied in community pharmacies remains unclear. This scoping review aimed to explore the scope of research on patient experience in community pharmacies.

Methods

This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. A comprehensive literature search was conducted in October 2024 using PubMed, Web of Science, and Google Scholar with predefined keywords, including “patient-centered,” “experience,” and “community pharmacy.”

Results

Of the 121 records identified, 15 studies, published between 2008 and 2024, met the eligibility criteria. These studies were conducted in Australia (n = 4), the United States (n = 3), and the United Kingdom (n = 3), with six studies published in non-English languages. Study methodologies included qualitative (n = 7), quantitative (n = 5), and mixed (n = 2). Four studies used patient-reported experience measures (PREMs). Terminology for study participants varied, with “patients” (n = 10), “consumers” (n = 3), and “customers” (n = 1). In addition, one study included pharmacists (n = 1) and another included caregivers (n = 1).

Conclusion

This review emphasizes advancing person-centered care in pharmacy practice, with a growing focus on patient experience in community pharmacies. Future studies should develop and implement patient-reported experience measures tailored to different social contexts to enhance care and service evaluation.

背景药剂师在社区环境中的作用正在扩大,了解患者体验-以人为本的护理的基本指标-对提高药房服务质量至关重要。然而,对社区药房患者经验的研究程度仍不清楚。本综述旨在探讨社区药房患者体验研究的范围。方法本综述遵循系统评价的首选报告项目和范围评价的元分析扩展指南。2024年10月,使用PubMed、Web of Science和谷歌Scholar进行了一次全面的文献检索,其中预定义的关键词包括“以患者为中心”、“体验”和“社区药房”。在确定的121项记录中,2008年至2024年间发表的15项研究符合资格标准。这些研究分别在澳大利亚(n = 4)、美国(n = 3)和英国(n = 3)进行,其中6项研究以非英语语言发表。研究方法包括定性(n = 7)、定量(n = 5)和混合(n = 2)。四项研究使用了患者报告的体验测量(PREMs)。研究参与者的术语各不相同,有“病人”(n = 10)、“消费者”(n = 3)和“顾客”(n = 1)。此外,一项研究包括药剂师(n = 1),另一项研究包括护理人员(n = 1)。结论本综述强调在药学实践中推进以人为本的护理,并日益关注社区药房的患者体验。未来的研究应根据不同的社会背景制定和实施患者报告的经验措施,以加强护理和服务评估。
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引用次数: 0
Rethinking community-based clinical training in Japan: Toward a more effective model for increasing the number of general practice physicians 日本以社区为基础的临床培训的反思:朝着增加全科医生数量的更有效的模式发展
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-09 DOI: 10.1002/jgf2.70038
Masanobu Okayama MD, PhD

The effectiveness of Community-Based Clinical Training (CBCT) in increasing the number of general practice physicians remains uncertain. In Japan, where the population is rapidly aging and shrinking, the demand for general practice physicians has significantly escalated to ensure adequate health care for the public, particularly in rural and underserved areas. General practice physicians are expected to play a vital role in providing comprehensive and continuous care to the aging population. Therefore, finding an effective strategy to secure an adequate number of general practice physicians is a crucial social issue.

CBCT is considered a promising approach to addressing this issue. It provides students and residents opportunities to engage with various aspects of community healthcare, including outpatient care, home visiting care, nurse home care, preventive care, health education, and more, particularly in rural and underserved areas. First introduced in the United States, CBCT has been implemented in numerous countries. It has spread rapidly worldwide since the 1990s, and nearly all medical schools and teaching hospitals in Japan offer this clinical training program.

Several studies have examined the effects of CBCT. Trainees report that their experiences during CBCT profoundly influence their understanding of general practice. They acknowledge the importance of acquiring diverse perspectives, understanding the physician's role, recognizing the significance of community care, respecting individual lifestyles, addressing multimorbidity, navigating various healthcare settings, and collaborating with different professionals.1 This training has a positive short-term impact on attitudes and awareness related to general practice and community healthcare. Participants' ratings of their attitudes and awareness significantly improved after the training, not only in rural areas,1 but also in urban settings.2

However, the effect of CBCT is insufficient regarding career preferences for general practice physicians. The research conducted with graduates from a single medical university suggests that conventional CBCT might not be sufficient in Japan for effectively developing general practice physicians.3 Additionally, a study at one teaching hospital indicated no positive relationship between the amount of compulsory undergraduate education in community-based medicine and the subsequent rise in the number of residents choosing general practice majors in Japan.4

A Longitudinal Integrated Clerkship (LIC) is a novel model of CBCT where students participate in the comprehensive care of patients over time and maintain ongoing learning relationships with both patients and supervising clinicians across multiple disciplines. Although there is no definitive minimum duration for student placements in an LIC program, severa

基于社区的临床培训(CBCT)在增加全科医生数量方面的有效性仍不确定。在人口迅速老龄化和萎缩的日本,对全科医生的需求大幅增加,以确保公众,特别是农村和服务不足地区的公众获得充分的医疗保健。全科医生在为老年人口提供全面和持续的护理方面发挥着至关重要的作用。因此,找到一个有效的策略来确保足够数量的全科医生是一个至关重要的社会问题。CBCT被认为是解决这一问题的有希望的方法。它为学生和居民提供了参与社区医疗保健各个方面的机会,包括门诊护理、家访护理、护士之家护理、预防保健、健康教育等等,特别是在农村和服务不足的地区。CBCT首先在美国推出,现已在许多国家实施。自20世纪90年代以来,它在世界范围内迅速传播,日本几乎所有的医学院和教学医院都提供这种临床培训计划。一些研究已经检验了CBCT的效果。学员报告说,他们在CBCT期间的经历深刻地影响了他们对全科医学的理解。他们承认获得不同观点的重要性,理解医生的角色,认识到社区护理的重要性,尊重个人生活方式,解决多重疾病,适应不同的医疗保健环境,并与不同的专业人员合作这种培训在短期内对与全科医疗和社区保健有关的态度和认识产生了积极的影响。不仅在农村地区,而且在城市环境中,参与者对自己的态度和意识的评分在培训后显著提高。然而,CBCT对全科医生职业偏好的影响是不够的。对一所医科大学的毕业生进行的研究表明,传统的CBCT可能不足以在日本有效地培养全科医生此外,在一家教学医院进行的一项研究表明,日本社区医学的义务本科教育数量与随后选择全科专业的住院医师数量的增加之间没有正相关关系。4a纵向综合实习(LIC)是一种新型的CBCT模式,学生长期参与患者的综合护理,并与患者和监督临床医生保持持续的学习关系学科。虽然在LIC项目中没有明确的最短实习时间,但通常采用几个月或更长时间。与持续2-4周的传统CBCT相比,LIC提供了更长的社区卫生保健接触时间。这种在社区的长期沉浸让学生成为医疗保健团队的一员,并与社区深入接触。据报道,低收入国家的学生拥有发达的以患者为中心的沟通技巧,对医学的社会心理贡献有理解,并在更高层次的临床和认知技能方面表现出更强的准备。他们对病人承担了更多的责任,并报告说他们在处理道德困境方面更有信心。此外,参与农村纵向综合见习项目与毕业生从事农村职业和初级保健专业之间存在正相关关系LIC模型显示出潜力;然而,需要进一步的研究来确定这些好处是否适用于城市环境。2009年,日本初级保健协会为家庭医学引入了董事会认证。自2018年以来,一个独立的第三方组织管理了一个新的国家专业认证体系,其中包括全科医生。在采取这些行动之前,没有委员会对全科医生的认证;现在,这个领域的环境发生了巨大的变化。这种情况为增加全科医生的数量提供了一个极好的机会。然而,目前的CBCT对于全科医生的有效发展可能还存在不足,有几个方面需要改进。项目协调员必须重新考虑学习目标、学习环境、培训周期、学习内容和活动、学习风格、教学技巧、社区互动和其他相关因素。因此,需要开发更有效的CBCT。还需要更多的研究来确定CBCT是否确实可以增加全科医生的数量。我们希望这个模棱两可的研究问题能够在未来得到解决。 冈山正信:概念化;写作——原稿;写作——审阅和编辑。作者声明不存在利益冲突。
{"title":"Rethinking community-based clinical training in Japan: Toward a more effective model for increasing the number of general practice physicians","authors":"Masanobu Okayama MD, PhD","doi":"10.1002/jgf2.70038","DOIUrl":"https://doi.org/10.1002/jgf2.70038","url":null,"abstract":"<p>The effectiveness of Community-Based Clinical Training (CBCT) in increasing the number of general practice physicians remains uncertain. In Japan, where the population is rapidly aging and shrinking, the demand for general practice physicians has significantly escalated to ensure adequate health care for the public, particularly in rural and underserved areas. General practice physicians are expected to play a vital role in providing comprehensive and continuous care to the aging population. Therefore, finding an effective strategy to secure an adequate number of general practice physicians is a crucial social issue.</p><p>CBCT is considered a promising approach to addressing this issue. It provides students and residents opportunities to engage with various aspects of community healthcare, including outpatient care, home visiting care, nurse home care, preventive care, health education, and more, particularly in rural and underserved areas. First introduced in the United States, CBCT has been implemented in numerous countries. It has spread rapidly worldwide since the 1990s, and nearly all medical schools and teaching hospitals in Japan offer this clinical training program.</p><p>Several studies have examined the effects of CBCT. Trainees report that their experiences during CBCT profoundly influence their understanding of general practice. They acknowledge the importance of acquiring diverse perspectives, understanding the physician's role, recognizing the significance of community care, respecting individual lifestyles, addressing multimorbidity, navigating various healthcare settings, and collaborating with different professionals.<span><sup>1</sup></span> This training has a positive short-term impact on attitudes and awareness related to general practice and community healthcare. Participants' ratings of their attitudes and awareness significantly improved after the training, not only in rural areas,<span><sup>1</sup></span> but also in urban settings.<span><sup>2</sup></span></p><p>However, the effect of CBCT is insufficient regarding career preferences for general practice physicians. The research conducted with graduates from a single medical university suggests that conventional CBCT might not be sufficient in Japan for effectively developing general practice physicians.<span><sup>3</sup></span> Additionally, a study at one teaching hospital indicated no positive relationship between the amount of compulsory undergraduate education in community-based medicine and the subsequent rise in the number of residents choosing general practice majors in Japan.<span><sup>4</sup></span></p><p>A Longitudinal Integrated Clerkship (LIC) is a novel model of CBCT where students participate in the comprehensive care of patients over time and maintain ongoing learning relationships with both patients and supervising clinicians across multiple disciplines. Although there is no definitive minimum duration for student placements in an LIC program, severa","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 5","pages":"383-384"},"PeriodicalIF":2.3,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with the cancer survivorship care practices of primary care physicians: A cross-sectional questionnaire study in Japan 与初级保健医生癌症生存护理实践相关的因素:日本横断面问卷调查研究
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-06-06 DOI: 10.1002/jgf2.70037
Akihiro Nishi MD, Hiroki Matsui MPH, Takashi Chinen MD, PhD, Sachi Takaoka MD, Takuji Seo MD, PhD, Satoshi Kanke MD, PhD, Teruhisa Azuma MD

Background

The involvement of primary care physicians (PCPs) is essential to meet the diverse needs of cancer survivors, yet their engagement remains insufficient. Consequently, identifying the factors associated with PCPs' practices in each component of cancer survivorship care is crucial. However, there is no study on the factors for individual care components. Therefore, we conducted a survey to identify the involvement and factors related to PCPs' practice of each component of cancer survivorship care.

Methods

A web-based questionnaire was distributed to 1091 family physicians in Japan. We identified four cancer survivorship care components: surveillance of recurrence, care for late effects, care for psychological problems, and care for social problems. The association between the practice of the components and the presence of knowledge or information resources, access to oncologists, and requests from patients and oncologists was evaluated.

Results

A total of 191 PCPs (response rate: 17.5%) responded, and 180 were included in the analysis. Multivariate logistic regression analyses revealed that knowledge or information resources were associated with care for late effects (odds ratio (OR), 5.09; 95% confidence interval (CI), 1.54–23.1) and psychological problems (OR, 4.77; 95% CI, 1.52–17.8). Access to oncologists was associated with surveillance of recurrence (OR, 2.97; 95% CI, 1.08–8.75). Requests from patients and oncologists were associated with almost all survivorship care components.

Conclusions

Requests from patients and oncologists might be key to PCPs' involvement in cancer survivorship care. PCPs need to be proactive in identifying patient needs and fostering trust from patients and oncologists for better cancer survivorship care.

背景:初级保健医生(pcp)的参与对于满足癌症幸存者的多样化需求至关重要,但他们的参与仍然不足。因此,在癌症生存护理的每个组成部分中,确定与pcp实践相关的因素至关重要。然而,对个体护理成分的影响因素尚无研究。因此,我们进行了一项调查,以确定pcp在癌症生存护理的每个组成部分的参与和相关因素。方法对日本1091名家庭医生进行网络问卷调查。我们确定了癌症生存期护理的四个组成部分:复发监测、晚期影响护理、心理问题护理和社会问题护理。评估了组件的实践与知识或信息资源的存在、与肿瘤学家的接触以及患者和肿瘤学家的要求之间的关系。结果共有191个pcp应答,有效率为17.5%,其中180个纳入分析。多因素logistic回归分析显示,知识或信息资源与晚期效应护理相关(优势比(or), 5.09;95%可信区间(CI), 1.54-23.1)和心理问题(OR, 4.77; 95% CI, 1.52-17.8)。与肿瘤医生接触与复发监测相关(OR, 2.97; 95% CI, 1.08-8.75)。来自患者和肿瘤学家的要求与几乎所有的生存护理组成部分相关。结论:患者和肿瘤学家的要求可能是pcp参与癌症生存护理的关键。pcp需要积极主动地识别患者的需求,并培养患者和肿瘤学家对更好的癌症生存护理的信任。
{"title":"Factors associated with the cancer survivorship care practices of primary care physicians: A cross-sectional questionnaire study in Japan","authors":"Akihiro Nishi MD,&nbsp;Hiroki Matsui MPH,&nbsp;Takashi Chinen MD, PhD,&nbsp;Sachi Takaoka MD,&nbsp;Takuji Seo MD, PhD,&nbsp;Satoshi Kanke MD, PhD,&nbsp;Teruhisa Azuma MD","doi":"10.1002/jgf2.70037","DOIUrl":"https://doi.org/10.1002/jgf2.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The involvement of primary care physicians (PCPs) is essential to meet the diverse needs of cancer survivors, yet their engagement remains insufficient. Consequently, identifying the factors associated with PCPs' practices in each component of cancer survivorship care is crucial. However, there is no study on the factors for individual care components. Therefore, we conducted a survey to identify the involvement and factors related to PCPs' practice of each component of cancer survivorship care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A web-based questionnaire was distributed to 1091 family physicians in Japan. We identified four cancer survivorship care components: surveillance of recurrence, care for late effects, care for psychological problems, and care for social problems. The association between the practice of the components and the presence of knowledge or information resources, access to oncologists, and requests from patients and oncologists was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 191 PCPs (response rate: 17.5%) responded, and 180 were included in the analysis. Multivariate logistic regression analyses revealed that knowledge or information resources were associated with care for late effects (odds ratio (OR), 5.09; 95% confidence interval (CI), 1.54–23.1) and psychological problems (OR, 4.77; 95% CI, 1.52–17.8). Access to oncologists was associated with surveillance of recurrence (OR, 2.97; 95% CI, 1.08–8.75). Requests from patients and oncologists were associated with almost all survivorship care components.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Requests from patients and oncologists might be key to PCPs' involvement in cancer survivorship care. PCPs need to be proactive in identifying patient needs and fostering trust from patients and oncologists for better cancer survivorship care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 5","pages":"465-474"},"PeriodicalIF":2.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy 孤立性颈部震颤作为长期阿立哌唑治疗的罕见迟发效应
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-05-27 DOI: 10.1002/jgf2.70032
Ryuichi Minoda Sada MD, Saki Sada Minoda MD
<p>Aripiprazole, a third-generation antipsychotic, demonstrates the pharmacodynamic characteristics of partial agonism, functional selectivity, and serotonin–dopamine activity modulation, representing the latest paradigm in managing major psychiatric conditions, including Bipolar II disorders.<span><sup>1</sup></span> Aripiprazole is also associated with a low incidence of tremors and is recommended as an alternative for patients experiencing tremors caused by other antipsychotics.<span><sup>2</sup></span> Here, we describe a case of isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy.</p><p>A 34-year-old female with a history of ovarian cystectomy and ongoing treatment for Bipolar II Disorder presented with a 3-month history of head tremors. She had been taking aripiprazole (3 mg/day) for over a decade with no other medications and demonstrated good medication adherence. Her mental state has remained stable over the past few years with the same dose of aripiprazole; apart from the tremors, there have been no relevant physical symptoms. She also denied having dystonic features, such as torticollis and hypertonia, and other extrapyramidal symptoms, including rigidity, hand tremor, reduced arm swing, bradykinesia, difficulty in maintaining posture, or a mask-like face. Working in an office environment, she had no known exposure to specialized chemicals. Additionally, her medical history revealed no instances of international travel or interaction with animals, and there was no evidence of sexual activity involving multiple partners. She was alert and vital signs were stable.</p><p>Physical examination revealed a resting tremor of the neck, approximately 3 Hz in the anterior–posterior direction (Video S1), with no other significant neurological findings. There were also no signs suggesting other extrapyramidal symptoms, such as Myerson's sign or the retropulsion test. Suspecting drug-induced tremor, aripiprazole was discontinued, leading to the complete resolution of the tremor within a week (Video S1). Therefore, she was diagnosed with isolated tardive neck tremor due to chronic aripiprazole use. Following psychiatric deterioration a month later, aripiprazole was resumed at 3 mg every 3 days, maintaining psychiatric stability without tremor recurrence.</p><p>Tardive tremor is a relatively rare component of drug-induced extrapyramidal symptoms, accounting for 2.4% of antipsychotic-induced extrapyramidal side effects.<span><sup>3</sup></span> This condition is commonly observed in patients who have been taking medication for an average period of more than 10 years<span><sup>4</sup></span>; thus, the absence of immediate onset should not preclude the consideration of drug-related side effects. While tremors are commonly present in the limbs, rare cases like this case involve head and neck manifestations.<span><sup>4</sup></span> Tardive tremors persist even after discontinuation of the causative medication in half of report
阿立哌唑是第三代抗精神病药物,具有部分激动作用、功能选择性和5 -羟色胺-多巴胺活性调节的药效学特征,代表了治疗包括双相情感障碍在内的主要精神疾病的最新范例阿立哌唑也与震颤发生率低有关,被推荐作为其他抗精神病药物引起震颤的患者的替代药物在这里,我们描述一个病例孤立的颈部震颤作为一个罕见的迟发效应长期阿立哌唑治疗。34岁女性,有卵巢囊肿切除术史,目前正在接受双相情感障碍治疗,有3个月的头部震颤史。她服用阿立哌唑(3毫克/天)超过十年,没有其他药物,并表现出良好的药物依从性。她的精神状态在过去几年中一直保持稳定,服用了相同剂量的阿立哌唑;除了震颤,没有相关的身体症状。她还否认有肌张力障碍特征,如斜颈和强直,以及其他锥体外系症状,包括强直、手颤、手臂摆动减少、运动迟缓、难以保持姿势或面具样脸。她在办公环境中工作,没有接触到特殊化学品。此外,她的病史显示没有国际旅行或与动物接触的情况,也没有与多名伴侣发生性行为的证据。她神志清醒,生命体征稳定。体格检查显示颈部静息性震颤,前后方向约3hz(视频S1),未见其他显著神经学表现。也没有迹象表明其他锥体外系症状,如迈尔森征或反推试验。怀疑药物性震颤,停用阿立哌唑,导致震颤在一周内完全消退(视频S1)。因此,她被诊断为长期使用阿立哌唑引起的孤立性迟发性颈部震颤。精神恶化1个月后,重新使用阿立哌唑,每3天3mg,保持精神稳定,无震颤复发。迟发性震颤是药物性锥体外系症状中相对罕见的组成部分,占抗精神病药物性锥体外系副作用的2.4%这种情况常见于平均服药时间超过10年的患者4;因此,没有立即发病不应排除考虑药物相关的副作用。虽然震颤通常出现在四肢,但像本例这样的病例很少出现在头颈部在一半的报告病例中,迟发性震颤甚至在停用致病性药物后仍持续存在如果没有观察到改善,应考虑使用丁苯那嗪总之,认识到阿立哌唑引起的震颤可能在长期使用中发生,并且可能只影响颈部,这一点至关重要。任何新发症状都应考虑药物引起的原因。田田龙一:概念化;写作——原稿;可视化;写作——审阅和编辑。Saki Minoda Sada:可视化;写作——审阅和编辑;监督。这项研究没有从公共、商业或非营利部门的资助机构获得任何具体的资助。作者明确表示,本文不存在任何利益冲突。伦理批准声明:根据日本国家指南,单个患者病例报告不需要机构审查委员会批准。患者同意声明:本病例报告的发表,包括任何附带的图像和视频,均已获得患者的知情同意。该患者的姓名已被保密。临床试验注册:无。
{"title":"Isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy","authors":"Ryuichi Minoda Sada MD,&nbsp;Saki Sada Minoda MD","doi":"10.1002/jgf2.70032","DOIUrl":"https://doi.org/10.1002/jgf2.70032","url":null,"abstract":"&lt;p&gt;Aripiprazole, a third-generation antipsychotic, demonstrates the pharmacodynamic characteristics of partial agonism, functional selectivity, and serotonin–dopamine activity modulation, representing the latest paradigm in managing major psychiatric conditions, including Bipolar II disorders.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Aripiprazole is also associated with a low incidence of tremors and is recommended as an alternative for patients experiencing tremors caused by other antipsychotics.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Here, we describe a case of isolated neck tremor as a rare tardive effect of long-term aripiprazole therapy.&lt;/p&gt;&lt;p&gt;A 34-year-old female with a history of ovarian cystectomy and ongoing treatment for Bipolar II Disorder presented with a 3-month history of head tremors. She had been taking aripiprazole (3 mg/day) for over a decade with no other medications and demonstrated good medication adherence. Her mental state has remained stable over the past few years with the same dose of aripiprazole; apart from the tremors, there have been no relevant physical symptoms. She also denied having dystonic features, such as torticollis and hypertonia, and other extrapyramidal symptoms, including rigidity, hand tremor, reduced arm swing, bradykinesia, difficulty in maintaining posture, or a mask-like face. Working in an office environment, she had no known exposure to specialized chemicals. Additionally, her medical history revealed no instances of international travel or interaction with animals, and there was no evidence of sexual activity involving multiple partners. She was alert and vital signs were stable.&lt;/p&gt;&lt;p&gt;Physical examination revealed a resting tremor of the neck, approximately 3 Hz in the anterior–posterior direction (Video S1), with no other significant neurological findings. There were also no signs suggesting other extrapyramidal symptoms, such as Myerson's sign or the retropulsion test. Suspecting drug-induced tremor, aripiprazole was discontinued, leading to the complete resolution of the tremor within a week (Video S1). Therefore, she was diagnosed with isolated tardive neck tremor due to chronic aripiprazole use. Following psychiatric deterioration a month later, aripiprazole was resumed at 3 mg every 3 days, maintaining psychiatric stability without tremor recurrence.&lt;/p&gt;&lt;p&gt;Tardive tremor is a relatively rare component of drug-induced extrapyramidal symptoms, accounting for 2.4% of antipsychotic-induced extrapyramidal side effects.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; This condition is commonly observed in patients who have been taking medication for an average period of more than 10 years&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;; thus, the absence of immediate onset should not preclude the consideration of drug-related side effects. While tremors are commonly present in the limbs, rare cases like this case involve head and neck manifestations.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Tardive tremors persist even after discontinuation of the causative medication in half of report","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 6","pages":"655-656"},"PeriodicalIF":2.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of General and Family Medicine
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