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Association between smartphone use, sleep deprivation, and self-rated health outcomes: A retrospective observational survey in rural Japan 智能手机使用、睡眠剥夺和自评健康结果之间的关系:日本农村的一项回顾性观察调查
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-29 DOI: 10.1002/jgf2.70024
Yoshio Hisata MD, PhD, Sakiya Nishida MD, Mamoru Urayama MD, Hiroshi Sekine MD, Takashi Sugioka MD, PhD, Risa Hirata MD, PhD, Naoko E. Katsuki MD, PhD, Masaki Tago MD, PhD, FACP, Yuki Ueda MD, Masaki Amenomori MD, Katsumi Higashino MD, PhD, Yoshio Naya MD, PhD

Background

Smartphone use significantly changes the lives of individuals. This study aimed to stratify sleep time by age and sex, examine the association between smartphone overuse and sleep deprivation, and measure their impact on self-rated health (SRH) outcomes. Focusing on communication and overuse, we also considered the association of active and passive smartphone use, as well as browsing, with sleep.

Methods

We conducted a questionnaire survey among residents of three towns in rural Japan to collect data on the sleeping hours, smartphone ownership rate, and smartphone usage time of residents, stratified according to sex and age. Logistic regression analysis was conducted to investigate the association among good SRH outcomes, sleep deprivation, and smartphone overuse.

Results

Among 2565 respondents to our questionnaire who possessed a smartphone (ownership 69.7%), 1172 men and 1393 women were analyzed. The mean age and sleep hours were 59.1 years and 6.7 h. Sleep time was shorter in middle-aged residents, and sex differences disappeared at younger ages. A total of 1295 participants experienced sleep deprivation. The smartphone overuse group comprised 627 participants. Good SRH outcomes were negatively associated with smartphone overuse and sleep deprivation. The group that used their smartphones for more than 1 h slept approximately 0.12–0.13 h less than the other group. Active/passive use and screen time were associated with good SRH outcomes.

Conclusion

Avoiding sleep deprivation and smartphone overuse are activities that are useful for good SRH outcomes. Smartphone use with a clear purpose may not be antagonistic to good SRH outcomes.

智能手机的使用极大地改变了人们的生活。这项研究旨在按年龄和性别对睡眠时间进行分层,研究过度使用智能手机和睡眠剥夺之间的关系,并衡量它们对自评健康(SRH)结果的影响。专注于交流和过度使用,我们还考虑了主动和被动使用智能手机以及浏览与睡眠的关系。方法对日本农村3个城镇的居民进行问卷调查,收集居民按性别和年龄分层的睡眠时间、智能手机拥有率和智能手机使用时间等数据。进行Logistic回归分析,以调查良好的SRH结果、睡眠剥夺和智能手机过度使用之间的关系。结果在2565名拥有智能手机的受访者中(69.7%),分析了1172名男性和1393名女性。平均年龄和睡眠时间分别为59.1岁和6.7小时。中年居民的睡眠时间较短,性别差异在年轻时消失。共有1295名参与者经历了睡眠剥夺。智能手机过度使用组由627名参与者组成。良好的SRH结果与过度使用智能手机和睡眠不足呈负相关。使用智能手机超过1小时的那一组比另一组睡眠时间大约少0.12-0.13小时。主动/被动使用和屏幕时间与良好的SRH结果相关。结论避免睡眠不足和过度使用智能手机是改善性生殖健康的有效措施。有明确目的的智能手机使用可能不会对良好的性生殖健康结果产生不利影响。
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引用次数: 0
Cortical ribbon sign: Initial sign of Creutzfeldt–Jakob disease 皮层带状征:克雅氏病的初步征象
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-25 DOI: 10.1002/jgf2.70019
Shiori Nakamichi MD, Ryohei Ono MD, Michihiro Kudo MD, Shigeto Horiuchi MD, Izumi Kitagawa MD
<p>A 72-year-old woman with a history of hypertension and hyperlipidemia presented with difficulty in speaking and writing. She noticed she became reluctant to do calculations 3 months earlier. The symptoms of aphasia and agraphia had gradually worsened over the prior 3 weeks; thus, she visited our hospital. Physical examinations showed motor aphasia, agraphia, and a positive Barre sign on the right side; however, tendon reflexes and the finger-to-nose test were normal, and there was no decrease in temperature, pain, or touch sensation. Laboratory data and head computed tomography showed no abnormalities. She subsequently underwent brain magnetic resonance imaging (MRI), showing high signal intensity areas on diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR), predominantly in the right frontal lobe region and in the bilateral occipitotemporal lobes (cortical ribbon sign) (Figure 1A,B). As the differential diagnoses included encephalitis, epileptic seizures, and Creutzfeldt–Jakob disease (CJD), she was admitted for further evaluation. The cerebrospinal fluid (CSF) was clear, with a white blood cell count of 6/μL, total protein level of 18.9 mg/dL, and glucose concentration of 63 mg/dL. Electroencephalography performed on Day 2 revealed no abnormalities, which made the diagnosis of epileptic seizures less likely. One week after admission, the patient became unable to say her name, and ataxic symptoms worsened. Given the possibility of autoimmune encephalitis, steroid pulse therapy was initiated; however, it was ineffective. Polymerase chain reaction testing for herpes simplex virus, as well as tests for anti-NMDA receptor antibody and paraneoplastic antibodies, submitted upon admission, later returned negative results, thereby ruling out encephalitis. By the third week of hospitalization, the patient had developed akinetic mutism, and myoclonus emerged on Day 25. Follow-up brain MRI one month after admission demonstrated extensive high signal intensity in the bilateral cerebral cortex and left striatum (Figure 1C,D), raising high suspicion for CJD. Electroencephalography revealed periodic sharp wave complexes (PSWC) (Figure 2). Moreover, additional CSF analysis revealed positive findings for T-Tau protein, 14-3-3 protein, and real-time quaking-induced conversion (RT-QuIC), confirming the diagnosis of CJD. Brain MRI 2 months after admission demonstrated high signal intensity in the bilateral cerebral cortex, as well as the bilateral striatum (Figure 1E,F), which was also characteristic of CJD. She was transferred to the rehabilitation hospital on Day 92.</p><p>CJD is a rare and fatal prion disease characterized by progressive dementia, typically over a period of a few weeks to months.<span><sup>1</sup></span> Although the diagnosis of CJD is challenging due to its non-specific manifestations, it is based on a combination of clinical symptoms, electroencephalography, CSF analysis, and MRI findings. Key clinical findings
一位72岁的女性,有高血压和高脂血症病史,表现为说话和写作困难。她发现自己在三个月前就不愿意做计算了。失语和失写症状在前3周逐渐加重;因此,她来了我们医院。体格检查显示运动失语症、失写症,右侧Barre征阳性;然而,肌腱反射和手指到鼻子的测试是正常的,并且没有降低温度,疼痛,或触觉。实验室数据和头部计算机断层扫描未见异常。随后,她接受了脑磁共振成像(MRI),在弥散加权成像(DWI)和液体衰减反转恢复(FLAIR)上显示高信号强度区域,主要在右侧额叶区域和双侧枕颞叶(皮质带征)(图1A,B)。由于鉴别诊断包括脑炎、癫痫发作和克雅氏病(CJD),她入院接受进一步评估。脑脊液清澈,白细胞计数6/μL,总蛋白水平18.9 mg/dL,葡萄糖浓度63 mg/dL。第2天的脑电图显示没有异常,这使得癫痫发作的诊断不太可能。入院一周后,患者无法说出自己的名字,共济失调症状加重。考虑到自身免疫性脑炎的可能性,类固醇脉冲治疗开始;然而,它是无效的。入院时进行单纯疱疹病毒聚合酶链反应试验,以及抗nmda受体抗体和副肿瘤抗体试验,结果均为阴性,因此排除脑炎。到住院第三周,患者出现了不动性缄默症,并于第25天出现肌阵挛。入院后1个月随访脑MRI显示双侧大脑皮层和左侧纹状体广泛高信号强度(图1C,D),高度怀疑为CJD。脑电图显示周期性尖锐波复合体(PSWC)(图2)。此外,脑脊液分析显示T-Tau蛋白、14-3-3蛋白和实时震动诱导转化(RT-QuIC)阳性,证实了CJD的诊断。入院后2个月的脑部MRI显示双侧大脑皮层和双侧纹状体高信号强度(图1E,F),这也是CJD的特征。第92天,她被转到康复医院。克雅氏病是一种罕见且致命的朊病毒疾病,其特征是进行性痴呆,通常持续几周到几个月虽然由于其非特异性表现,CJD的诊断具有挑战性,但它是基于临床症状、脑电图、脑脊液分析和MRI结果的综合诊断。主要临床表现包括快速进行性认知能力下降、共济失调和肌阵挛。典型的脑电图可能显示PSWC,而脑脊液生物标志物,如14-3-3和tau蛋白,对诊断有用,RT-QuIC检测对检测异常的朊病毒蛋白具有高灵敏度和特异性。此外,脑MRI是协助CJD生前诊断的最有用的成像工具。2 CJD的一个特征性MRI发现是在至少两个皮质区域存在限制性扩散,称为皮质带征,同时主要在尾状核中存在限制性扩散,其次是壳核和丘脑因此,皮质带状征可以作为早期诊断CJD的关键放射学发现,其存在应提示医生在鉴别诊断中考虑CJD。Shiori Nakamichi:概念化;方法;调查;验证;可视化;写作-原稿。小野良平:概念化;方法;调查;验证;正式的分析;可视化;写作——原稿;写作——审阅和编辑。工藤道弘:概念化;方法;调查;验证;可视化;写作-原稿。Shigeto Horiuchi:概念化;方法;调查;验证;可视化;写作-原稿。Izumi Kitagawa:概念化;方法;验证;可视化;写作——审阅和编辑;监督。作者明确表示,本文不存在任何利益冲突。伦理批准声明:我们确认,临床图像和随附文本的发表已获得患者近亲属的知情同意。病人的近亲被告知,图片和文字将发表在公众可访问的期刊上,并通过省略可识别的信息来确保匿名。 患者同意声明:由于患者患有进行性痴呆,因此获得了患者近亲属的知情同意,并且保留了患者的匿名性。临床试验注册:无。
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引用次数: 0
Drug-induced liver injury associated with exposure to Hangeshashinto 药物性肝损伤与暴露于Hangeshashinto相关
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-24 DOI: 10.1002/jgf2.70018
Kimitoshi Kubo MD, PhD, Issei Ashida MD, Noriko Kimura MD, PhD

While Kampo medicines are deemed relatively safe and associated with few adverse effects, primary care physicians are well advised to be aware of the risk of drug-induced liver injury in patients prescribed Kampo medicines containing Scutellariae radix, such as Hangeshashinto, in clinical practice and to closely monitor their clinical course.

虽然汉布药被认为是相对安全的,而且几乎没有不良反应,但建议初级保健医生在临床实践中意识到给病人开含有黄芩的汉布药(如杭沙沙)时药物性肝损伤的风险,并密切监测其临床过程。
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引用次数: 0
Avoiding early diagnosis 避免早期诊断
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-24 DOI: 10.1002/jgf2.70015
Takao Wakabayashi M.D., Ph.D., Goh Keng Wee M.D., Mikinosuke Ishibashi M.D., Yoshiki Akiyama M.D., Naoki Kanda M.D., Tomoyuki Watanabe M.D., Ph.D.
<p>A previously healthy 27-year-old woman was referred from a nearby clinic for the treatment of pneumonia.</p><p> <i>The patient was referred with a diagnosis of community-acquired pneumonia (CAP). Hospitalization for CAP is generally indicated when the oxygen saturation on room air falls to ≤93%, or when severity scores such as a Pneumonia Severity Index score of ≥III or a CURB-65 score of ≥1 are present.</i> </p><p>Five days prior to referral, the patient visited her primary care physician with complaints of high fever, nasal discharge, and pharyngitis. Although a rapid influenza test was negative, baloxavir marboxil was administered based on the local outbreak situation. However, her fever persisted, and she revisited the clinic 1 day before referral. Blood tests and chest computed tomography (CT) were performed, leading to a diagnosis of pneumonia. She received an outpatient dose of 2 g of ceftriaxone and was prescribed levofloxacin at 500 mg/day. The next day, marked inflammatory markers were revealed in blood tests, prompting her referral.</p><p>Administering antibiotics without obtaining various cultures for infections such as pneumonia is not recommended. Additionally, initiating treatment with fluoroquinolones, such as levofloxacin, at the first visit is also discouraged. This is because fluoroquinolones have some efficacy against mycobacteria, including tuberculosis, which can delay the diagnosis of these conditions.</p><p>The patient reported intermittent high-grade fevers, sore throat, pleuritic chest pain, and fatigue. They reported no rash, cough, vomiting, constipation, diarrhea, genitourinary symptoms, or weakness. They had previously had sinusitis. She did not take prescription medications, smoke, drink alcohol, or use drugs. She was not sexually active. She had no recent exposures to sick contacts, hot springs, travel history, undercooked meats, or bites from insects or animals.</p><p>This review of systems highlights multisystem involvement and eliminates several potentially relevant exposures. The presence of fevers and fatigue points toward infectious, inflammatory, or malignant processes.</p><p>On physical examination, her consciousness was alert, the patient was febrile; her axillary temperature was 38.0°C, the heart rate was 110 beats per minute, the blood pressure was 99/50 mm Hg, the respiratory rate was 20 per minute, and the oxygen saturation was 97% while the patient was breathing ambient air. The body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) was 19.9. Cardiopulmonary examinations revealed that holo crackles were auscultated in the right lower lung field, and a systolic murmur (Levine grade 3/6) was heard at the apex. No signs of arthritis or skin abnormalities were shown. The patient's mood, attention, and affect were appropriate.</p><p>If this case is confirmed to be pneumonia, hospitalization is indicated. While both the PSI and CURB-65 scores
一名以前健康的27岁妇女从附近一家诊所转介治疗肺炎。患者被诊断为社区获得性肺炎(CAP)。当室内空气氧饱和度降至≤93%,或出现肺炎严重程度指数评分≥III或CURB-65评分≥1等严重程度评分时,通常需要住院治疗CAP。转诊前5天,患者以高热、流鼻液和咽炎主诉就诊于初级保健医生。尽管快速流感试验呈阴性,但根据当地疫情情况给予了巴洛韦-马博西。然而,她的发烧持续存在,并在转诊前1天再次来到诊所。进行了血液检查和胸部计算机断层扫描(CT),诊断为肺炎。她接受门诊剂量2g头孢曲松,并开左氧氟沙星500毫克/天。第二天,在血液检查中发现明显的炎症标志物,促使她转诊。不建议在未获得肺炎等感染的各种培养物的情况下使用抗生素。此外,也不鼓励在第一次就诊时就开始使用氟喹诺酮类药物,如左氧氟沙星。这是因为氟喹诺酮类药物对分枝杆菌(包括结核病)有一定疗效,这可能会延迟这些疾病的诊断。患者报告间歇性高热、喉咙痛、胸膜炎性胸痛和疲劳。他们报告没有皮疹、咳嗽、呕吐、便秘、腹泻、泌尿生殖系统症状或虚弱。他们之前患有鼻窦炎。她不服用处方药,不吸烟,不喝酒,也不吸毒。她没有性生活。她最近没有接触病人、温泉、旅行史、未煮熟的肉类或被昆虫或动物咬伤。这种系统审查强调了多系统参与,并消除了几个潜在的相关暴露。发热和疲劳提示有感染、炎症或恶性病变。体格检查,患者意识清醒,发热;患者呼吸环境空气时腋窝温度38.0℃,心率110次/ min,血压99/50 mm Hg,呼吸频率20次/ min,血氧饱和度97%。身体质量指数(BMI;体重(公斤)除以身高(米)的平方是19.9。心肺检查显示右下肺野可听出空心杂音,心尖处可听到收缩期杂音(Levine 3/6级)。没有关节炎或皮肤异常的迹象。病人的情绪、注意力和情绪都是适当的。如果确诊为肺炎,则需要住院治疗。虽然PSI和CURB-65评分都很低,并且维持了氧饱和度,但休克指数(SI)——以心率除以收缩压计算——超过了1.0。一般来说,指数高于0.9预示着情况严重。虽然SI在老年患者中更具预测性,但在年轻人中也不容忽视。此外,听诊中全息裂纹的出现与肺炎的早期表现一致。然而,仅仅根据这些发现确诊肺炎还为时过早。考虑到患者处于高动力状态,我认为在本病例中听诊的心脏杂音是功能性的。然而,对于不明原因发热的评估,我建议进行经胸超声心动图作为初步评估。患者实验室结果显示白细胞计数为每微升15,440(正常范围:3,500-9,700),绝对中性粒细胞计数为每微升13,100(正常范围:1,120-7,189)。血红蛋白水平为12.8 g/dL,平均红细胞体积为86.2 fl,血小板计数为每微升30,000个细胞(正常范围:140,000-379,000 c)。肌酐0.83 mg/dL(正常范围:0.46 ~ 0.82)。血清白蛋白和电解质水平(包括钙和磷酸盐)在正常范围内,肝功能测试也在正常范围内。尿检显示蛋白1+,血3+。d -二聚体升高至2.49 μg/mL(正常范围:0.00 ~ 1.00)。国际标准化比值(INR)和纤维蛋白原水平均正常。c反应蛋白(CRP)水平明显升高,为34.14 mg/dL(正常值≤0.5)。本病例表现为显著升高的炎症标志物,这在自身免疫性疾病中通常不常见。考虑到急性发作,我怀疑是感染所致。此外,观察到血小板减少,增加了弥散性血管内凝血(DIC)的可能性。感染引起的DIC的治疗通常包括解决潜在疾病。然而,在某些情况下可以考虑给肝素。 该病例显示典型社区获得性肺炎的炎症标志物明显升高,除了治疗外,还需要进一步调查。入院时的胸部x光片显示右侧半膈阳性影影。由于没有前一位医生提供的图像,为了确定,再次检查胸部CT,双肺胸膜可见多发浸润性结节影(图1A)。此外,右中、下肺野可见反转晕征(图1B)。在此基础上,开始治疗和进一步分析,不仅考虑单纯的细菌性肺炎,而且考虑脓毒性栓塞。此外,CT显示间质性肺炎伴组织性肺炎(OP)型。我们最初以社区获得性肺炎的假设开始评估,但似乎情况并非如此。高分辨率CT显示密度增加厚度超过2mm,在中心磨玻璃混浊周围形成新月形或环状。这一发现被定义为反向晕征,被认为是隐源性组织性肺炎(COP)的特征。然而,在慢性嗜酸性粒细胞性肺炎和结节病的病例中也有类似的发现。在这个病例中,胸膜下出现多个结节阴影,以及患者的年龄和发病方式,提示,正如主讲人指出的,脓毒性栓塞的可能性。在诊断不明确的情况下,我们必须真诚地倾听病人的声音。换句话说,医学采访是至关重要的,我们应该采取的历史和发现,不符合典型的表现肺炎。我想看看脓毒性栓子在肺外感染的可能性。如果没有发现这样的病灶,我想用支气管镜收集细胞。入院后行血、痰培养进行病原体鉴定,肺炎开始用ABPC/SBT 3 g × 4/d、那那巴苷钠1250单位× 2/d治疗。在入院时提交的作为不明原因发热评估的一部分的测试结果已被披露。类风湿因子、抗核抗体、CCP抗体、MPO-ANCA、PR3-ANCA均为阴性。此外,补体水平升高。由于补体水平升高,抗核抗体呈阴性,因此发生系统性红斑狼疮(SLE)的可能性较低。MPO-ANCA在显微镜下多血管炎、过敏性肉芽肿病和血管炎(Churg-Strauss综合征)、缺乏免疫坏死性新月形肾小球肾炎、系统性硬化症和Goodpasture综合征等情况下升高。PR3-ANCA在韦格纳肉芽肿病等情况下升高。因此,这些疾病的预测概率降低了。补体水平的增加表明非特异性炎症。补体水平的降低有时可用于诊断。入院后,患者生命体征表现为相对心动过缓(图2)。在发热情况下,体温升高超过38.3℃通常伴随着每分钟约8-10次的心率升高。这种关系,历史上被称为利伯迈斯特法则,在19世纪末由卡尔·冯·利伯迈斯特首次记录。相对心动过缓,又称费格特征,其特点是发热时心动过速反应减弱。在细胞内病原体引起的感染中,包括军团菌和伤寒沙门氏菌,经常观察到相对心动过缓。它还与中枢神经系统病变、淋巴瘤、药物性发热和成人发病的斯蒂尔氏病等疾病有关。因此,相对心动过缓被认为是一种非特异性但具有临床意义的指标,可能有助于在床边区分感染性和非感染性原因。值得注意的是,没有电解质失衡或肝功能障碍,军团菌感染的可能性很低。然而,在鉴别诊断中应考虑军团菌,并使用尿抗原试验等方法进行检查。此外,虽然经胸超声心动图不能明确排除感染性心内膜炎,但应进行经胸超声心动图检查。一些感染,如Q热,可引起心内膜炎,并伴有相对心动过缓。之前,我强调了考虑病人观点的重要性。在患者报告的症状中,是否存在可能影响肺炎诊断的差异?例如,病人提到的喉咙痛解决了吗?口咽检查结果说明什么?相对心动过缓的存在肯定会缩小鉴别诊断的范围。 然而,尿军团菌抗原检测和自身免疫性疾病的抗体检测需要时间。我们需要寻找发烧的原因而不必过分担心相对的心动过缓。我们应该根据病人报告的情况采取行动。我们考虑了军团菌肺炎和自身免疫性疾病的可能性,重点是相对心动过缓的存在。在鉴别诊断时考虑自身免疫性疾病,如血管炎,并收集各种自身抗体。尿军团菌抗原阴性。入院第二天怀疑感染性心内膜炎,行经胸超声心动图检查,未见异常。由于患者自入院以来一直抱怨喉咙痛,因此在入院第3天,行颈部CT增强检查,提示颈内静脉分支腹
{"title":"Avoiding early diagnosis","authors":"Takao Wakabayashi M.D., Ph.D.,&nbsp;Goh Keng Wee M.D.,&nbsp;Mikinosuke Ishibashi M.D.,&nbsp;Yoshiki Akiyama M.D.,&nbsp;Naoki Kanda M.D.,&nbsp;Tomoyuki Watanabe M.D., Ph.D.","doi":"10.1002/jgf2.70015","DOIUrl":"https://doi.org/10.1002/jgf2.70015","url":null,"abstract":"&lt;p&gt;A previously healthy 27-year-old woman was referred from a nearby clinic for the treatment of pneumonia.&lt;/p&gt;&lt;p&gt;\u0000 &lt;i&gt;The patient was referred with a diagnosis of community-acquired pneumonia (CAP). Hospitalization for CAP is generally indicated when the oxygen saturation on room air falls to ≤93%, or when severity scores such as a Pneumonia Severity Index score of ≥III or a CURB-65 score of ≥1 are present.&lt;/i&gt;\u0000 &lt;/p&gt;&lt;p&gt;Five days prior to referral, the patient visited her primary care physician with complaints of high fever, nasal discharge, and pharyngitis. Although a rapid influenza test was negative, baloxavir marboxil was administered based on the local outbreak situation. However, her fever persisted, and she revisited the clinic 1 day before referral. Blood tests and chest computed tomography (CT) were performed, leading to a diagnosis of pneumonia. She received an outpatient dose of 2 g of ceftriaxone and was prescribed levofloxacin at 500 mg/day. The next day, marked inflammatory markers were revealed in blood tests, prompting her referral.&lt;/p&gt;&lt;p&gt;Administering antibiotics without obtaining various cultures for infections such as pneumonia is not recommended. Additionally, initiating treatment with fluoroquinolones, such as levofloxacin, at the first visit is also discouraged. This is because fluoroquinolones have some efficacy against mycobacteria, including tuberculosis, which can delay the diagnosis of these conditions.&lt;/p&gt;&lt;p&gt;The patient reported intermittent high-grade fevers, sore throat, pleuritic chest pain, and fatigue. They reported no rash, cough, vomiting, constipation, diarrhea, genitourinary symptoms, or weakness. They had previously had sinusitis. She did not take prescription medications, smoke, drink alcohol, or use drugs. She was not sexually active. She had no recent exposures to sick contacts, hot springs, travel history, undercooked meats, or bites from insects or animals.&lt;/p&gt;&lt;p&gt;This review of systems highlights multisystem involvement and eliminates several potentially relevant exposures. The presence of fevers and fatigue points toward infectious, inflammatory, or malignant processes.&lt;/p&gt;&lt;p&gt;On physical examination, her consciousness was alert, the patient was febrile; her axillary temperature was 38.0°C, the heart rate was 110 beats per minute, the blood pressure was 99/50 mm Hg, the respiratory rate was 20 per minute, and the oxygen saturation was 97% while the patient was breathing ambient air. The body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) was 19.9. Cardiopulmonary examinations revealed that holo crackles were auscultated in the right lower lung field, and a systolic murmur (Levine grade 3/6) was heard at the apex. No signs of arthritis or skin abnormalities were shown. The patient's mood, attention, and affect were appropriate.&lt;/p&gt;&lt;p&gt;If this case is confirmed to be pneumonia, hospitalization is indicated. While both the PSI and CURB-65 scores ","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 4","pages":"292-296"},"PeriodicalIF":1.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of idiopathic mesenteric phlebosclerosis: Insight into pathogenesis of associated vascular calcification 特发性肠系膜静脉硬化1例:相关血管钙化的发病机制探讨
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-24 DOI: 10.1002/jgf2.70025
Kimitoshi Kubo MD, PhD, Noriko Kimura MD, PhD

A 75-year-old woman had been taking a geniposide-containing herbal medicine for 7 years and was admitted to our hospital for nausea, abdominal pain, and distention. CT revealed colonic wall thickening, whereas CS revealed a dark-purple edematous mucosa. Furthermore, biopsy specimens revealed small vein hyalinization. Thus, she was diagnosed with idiopathic mesenteric phlebosclerosis (IMP) and underwent surgery. von Kossa staining revealed granules in the mucosal, submucosal, muscular, and subserosal layers, with mesenteric veins demonstrating calcium deposition. Taken together, calcium ion deposition was likely to have accounted for vascular wall calcification in IMP. The patient's course was uneventful for 3 months after surgery.

一名75岁妇女服用含京尼皂苷的草药7年,因恶心、腹痛和腹胀入院。CT示结肠壁增厚,CS示深紫色水肿粘膜。此外,活检标本显示小静脉透明。因此,她被诊断为特发性肠系膜静脉硬化(IMP)并接受了手术。von Kossa染色显示粘膜、粘膜下、肌层和浆膜下均可见颗粒,肠系膜静脉可见钙沉积。综上所述,钙离子沉积可能是导致IMP血管壁钙化的原因。术后3个月,患者病程平稳。
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引用次数: 0
The educational effects of telemedicine training using role-playing for general practice/family medicine residents: A qualitative study 角色扮演远程医疗培训对全科医生/家庭医生住院医师的教育效果:一项定性研究
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-21 DOI: 10.1002/jgf2.70020
Koki Nakamura MD, PhD, Tomoo Hidaka MD, PhD, Yoshihiro Toyoda MD, Mei Endo MD, Satoshi Kanke MD, PhD

Background

Despite the increasing demand for telemedicine, there have been few reports on telemedicine training for general practice/family medicine residents. This study aimed to qualitatively examine the educational effects of remote medical training for residents using role-play.

Methods

This study targeted first- and second-year residents enrolled in the General Medicine/Family Medicine Residency Program at Fukushima Medical University in 2023. The residents watched educational videos on telemedicine and engaged in role-playing training based on multiple scenarios. Subsequently, interviews were conducted with the residents, and the verbatim transcripts of the audio data were thematically analyzed using open coding.

Results

Eight residents participated in the study, with each undergoing 3–4 interviews. The identified codes were inductively summarized, and nine categories were generated: verbal cues to enhance the quality of history taking, nonverbal communication to connect with patients, addressing risks inherent in the convenience of telemedicine, co-creating a clinical environment with patients, anticipating issues different from those encountered in face-to-face consultation rooms, considering and supporting the elderly and those who are digitally disadvantaged, improving access restrictions due to busyness and resistance to telemedicine, understanding the living environment in connection with patient families and home care nurses, and awareness of the wide-ranging applications of telemedicine.

Conclusion

The results of telemedicine training via role-play suggest various educational effects. This study provides crucial findings for considering educational methods for GM/FM residents to respond to the increasing demand for telemedicine in primary health care.

背景尽管远程医疗的需求不断增加,但关于全科/家庭医学住院医师远程医疗培训的报道很少。摘要本研究旨在定性检验角色扮演式住院医师远程医疗培训的教育效果。方法本研究以2023年入读福岛医科大学全科医学/家庭医学住院医师项目的一、二年级住院医师为研究对象。住院医生观看了远程医疗的教育视频,并参与了基于多种场景的角色扮演培训。随后,与居民进行访谈,并使用开放编码对音频数据的逐字记录进行主题分析。结果共8名住院医师参与研究,每人接受3-4次访谈。对识别出的代码进行归纳总结,得到9个类别:语言提示提高病史记录质量,非语言沟通与患者联系,解决远程医疗便利性固有的风险,与患者共同创造临床环境,预测不同于面对面会诊室遇到的问题,考虑并支持老年人和数字弱势群体,改善因忙碌和抵制远程医疗而导致的访问限制,了解与患者家属和家庭护理护士相关的生活环境,并了解远程医疗的广泛应用。结论角色扮演式远程医疗培训具有多种教育效果。本研究为考虑GM/FM居民的教育方法提供了重要的发现,以应对初级卫生保健中日益增长的远程医疗需求。
{"title":"The educational effects of telemedicine training using role-playing for general practice/family medicine residents: A qualitative study","authors":"Koki Nakamura MD, PhD,&nbsp;Tomoo Hidaka MD, PhD,&nbsp;Yoshihiro Toyoda MD,&nbsp;Mei Endo MD,&nbsp;Satoshi Kanke MD, PhD","doi":"10.1002/jgf2.70020","DOIUrl":"https://doi.org/10.1002/jgf2.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite the increasing demand for telemedicine, there have been few reports on telemedicine training for general practice/family medicine residents. This study aimed to qualitatively examine the educational effects of remote medical training for residents using role-play.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study targeted first- and second-year residents enrolled in the General Medicine/Family Medicine Residency Program at Fukushima Medical University in 2023. The residents watched educational videos on telemedicine and engaged in role-playing training based on multiple scenarios. Subsequently, interviews were conducted with the residents, and the verbatim transcripts of the audio data were thematically analyzed using open coding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight residents participated in the study, with each undergoing 3–4 interviews. The identified codes were inductively summarized, and nine categories were generated: verbal cues to enhance the quality of history taking, nonverbal communication to connect with patients, addressing risks inherent in the convenience of telemedicine, co-creating a clinical environment with patients, anticipating issues different from those encountered in face-to-face consultation rooms, considering and supporting the elderly and those who are digitally disadvantaged, improving access restrictions due to busyness and resistance to telemedicine, understanding the living environment in connection with patient families and home care nurses, and awareness of the wide-ranging applications of telemedicine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of telemedicine training via role-play suggest various educational effects. This study provides crucial findings for considering educational methods for GM/FM residents to respond to the increasing demand for telemedicine in primary health care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 4","pages":"334-345"},"PeriodicalIF":1.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telemedicine-based diagnosis and management of ocular chemical injury in a remote setting: A case report 基于远程医疗的眼部化学损伤的诊断和管理:一例报告
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-18 DOI: 10.1002/jgf2.70017
Eisuke Shimizu MD, PhD, Hiroki Nishimura MSc, CO, Rohan Jeetendra Khemlani MD, Shintaro Nakayama MSc, Keitaro Suzuki MD, Katsuya Sato MD

Ocular chemical injuries require immediate diagnosis and treatment, posing challenges in remote regions. We report a case of mild chemical injury caused by an alkali chemical injury, successfully diagnosed and managed using telemedicine. A primary care physician utilized a smartphone-based anterior segment imaging system (Smart Eye Camera), allowing an ophthalmologist to remotely evaluate and classify the injury as Roper-Hall grade. Conservative treatment with irrigation and topical medications led to symptom resolution within 1 week. This case highlights the effectiveness of teleophthalmology, suggesting its significant potential for improving ocular care accessibility and timely intervention in medically underserved rural areas.

眼部化学损伤需要立即诊断和治疗,这给偏远地区带来了挑战。我们报告一例由碱化学损伤引起的轻度化学损伤,成功地诊断和管理使用远程医疗。初级保健医生使用基于智能手机的前段成像系统(智能眼相机),允许眼科医生远程评估并将损伤分类为Roper-Hall级。保守的冲洗和局部药物治疗使症状在1周内消失。该病例突出了远距眼科的有效性,表明其在改善医疗服务不足的农村地区的眼科护理可及性和及时干预方面具有巨大潜力。
{"title":"Telemedicine-based diagnosis and management of ocular chemical injury in a remote setting: A case report","authors":"Eisuke Shimizu MD, PhD,&nbsp;Hiroki Nishimura MSc, CO,&nbsp;Rohan Jeetendra Khemlani MD,&nbsp;Shintaro Nakayama MSc,&nbsp;Keitaro Suzuki MD,&nbsp;Katsuya Sato MD","doi":"10.1002/jgf2.70017","DOIUrl":"https://doi.org/10.1002/jgf2.70017","url":null,"abstract":"<p>Ocular chemical injuries require immediate diagnosis and treatment, posing challenges in remote regions. We report a case of mild chemical injury caused by an alkali chemical injury, successfully diagnosed and managed using telemedicine. A primary care physician utilized a smartphone-based anterior segment imaging system (Smart Eye Camera), allowing an ophthalmologist to remotely evaluate and classify the injury as Roper-Hall grade. Conservative treatment with irrigation and topical medications led to symptom resolution within 1 week. This case highlights the effectiveness of teleophthalmology, suggesting its significant potential for improving ocular care accessibility and timely intervention in medically underserved rural areas.</p>","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 4","pages":"359-362"},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary care experiences of family caregivers using the same medical facility as their care recipient or a different facility 家庭照护者与被照护者使用同一医疗机构或不同医疗机构的初级保健经验
IF 1.8 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-18 DOI: 10.1002/jgf2.70000
Gen Nakayama MD, PhD, Shoichi Masumoto MD, MPH, PhD, Junji Haruta MD, PhD, Tetsuhiro Maeno MD, PhD

Background

Family caregivers and care recipients do not always have the same usual source of care, which may create barriers to providing optimal care for caregivers. This study aimed to compare family caregivers' primary care experiences based on whether they used the same medical facility as their care recipient or a different facility.

Methods

We used cross-sectional data from a survey conducted in Japan in 2020. Participants were family caregivers aged 40–74 years who cared for community-dwelling adults with chronic conditions. Caregivers' primary care experiences were assessed using the Japanese version of the Primary Care Assessment Tool Short Form (JPCAT-SF). Multivariable linear regression analyses were conducted to evaluate differences in JPCAT-SF scores between caregivers who used the same medical facility as their care recipient and those who used a different facility.

Results

Of the 406 family caregivers analyzed, 216 (53.2%) used a different medical facility from their care recipient. After adjusting for possible confounders, JPCAT-SF total scores were significantly lower among family caregivers using a different facility compared with those using the same facility (adjusted mean difference −5.73, 95% confidence interval: −8.93 to −2.54). The JPCAT-SF subscale scores for longitudinality, comprehensiveness (services available), and community orientation were significantly lower in the different facility group than the same facility group.

Conclusions

Family caregivers who used a different medical facility from their care recipient reported more negative primary care experiences than caregivers using the same facility. Greater efforts may be needed to provide patient-centered, family-oriented primary care for these caregivers.

家庭照护者和接受照护者并不总是有相同的照护来源,这可能会对为照护者提供最佳照护造成障碍。本研究旨在比较家庭照顾者的初级保健经验,基于他们是否使用相同的医疗机构作为他们的照顾对象或不同的设施。方法我们使用了2020年在日本进行的一项调查的横断面数据。参与者是40-74岁的家庭照顾者,他们照顾社区居住的慢性病成年人。使用日文版初级保健评估工具简表(JPCAT-SF)对护理人员的初级保健经历进行评估。采用多变量线性回归分析来评估与护理对象使用相同医疗机构的护理人员与使用不同医疗机构的护理人员在JPCAT-SF评分上的差异。结果在分析的406名家庭照护者中,216名(53.2%)使用与照护者不同的医疗机构。在对可能的混杂因素进行调整后,使用不同设施的家庭照顾者与使用相同设施的家庭照顾者相比,JPCAT-SF总分显著降低(调整后的平均差值为- 5.73,95%置信区间为- 8.93至- 2.54)。在纵向性、综合性(可获得的服务)和社区导向方面,不同设施组的JPCAT-SF分量表得分显著低于同一设施组。结论:使用不同医疗机构的家庭照护者比使用相同医疗机构的家庭照护者报告了更多的负面初级保健经历。可能需要作出更大的努力,为这些护理人员提供以患者为中心、以家庭为导向的初级保健。
{"title":"Primary care experiences of family caregivers using the same medical facility as their care recipient or a different facility","authors":"Gen Nakayama MD, PhD,&nbsp;Shoichi Masumoto MD, MPH, PhD,&nbsp;Junji Haruta MD, PhD,&nbsp;Tetsuhiro Maeno MD, PhD","doi":"10.1002/jgf2.70000","DOIUrl":"https://doi.org/10.1002/jgf2.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Family caregivers and care recipients do not always have the same usual source of care, which may create barriers to providing optimal care for caregivers. This study aimed to compare family caregivers' primary care experiences based on whether they used the same medical facility as their care recipient or a different facility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used cross-sectional data from a survey conducted in Japan in 2020. Participants were family caregivers aged 40–74 years who cared for community-dwelling adults with chronic conditions. Caregivers' primary care experiences were assessed using the Japanese version of the Primary Care Assessment Tool Short Form (JPCAT-SF). Multivariable linear regression analyses were conducted to evaluate differences in JPCAT-SF scores between caregivers who used the same medical facility as their care recipient and those who used a different facility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 406 family caregivers analyzed, 216 (53.2%) used a different medical facility from their care recipient. After adjusting for possible confounders, JPCAT-SF total scores were significantly lower among family caregivers using a different facility compared with those using the same facility (adjusted mean difference −5.73, 95% confidence interval: −8.93 to −2.54). The JPCAT-SF subscale scores for longitudinality, comprehensiveness (services available), and community orientation were significantly lower in the different facility group than the same facility group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Family caregivers who used a different medical facility from their care recipient reported more negative primary care experiences than caregivers using the same facility. Greater efforts may be needed to provide patient-centered, family-oriented primary care for these caregivers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 4","pages":"297-304"},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upper extremity deep vein thrombosis associated with systemic lupus erythematosus and antiphospholipid syndrome 与系统性红斑狼疮和抗磷脂综合征相关的上肢深静脉血栓形成
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-18 DOI: 10.1002/jgf2.70023
Masahiro Yabe MD, Nozomi Ozaki MD, Nobuhiro Sato MD, MPH, PhD, Norihito Nakamura MD, PhD, Azusa Aoyama MD, Shuichi Murakami MD, PhD, Yasuo Hirose MD
<p>A 35-year-old woman with epilepsy and infertility presented with a 2-day history of left upper extremity swelling. Symptoms began after traveling, likely due to prolonged immobility followed by vigorous upper extremity activity and pressure from a leather bag on the left arm, contributing to venous stasis. She also reported experiencing recurrent headaches over the past 6 months. The patient was taking levetiracetam, lamotrigine, folic acid, and loxoprofen, none of which are associated with thrombotic risk. On examination, the left upper extremity exhibited swelling (Figure 1A) and superficial venous dilatation extending to the chest (Figure 1B). Laboratory findings demonstrated leukopenia, lymphopenia, a prolonged activated partial thromboplastin time, and a D-dimer level of 0.9 μ/mL (reference <1.0 μ/mL).</p><p>Chest contrast-enhanced computed tomography (CT) revealed thrombosis in the left axillary to the subclavian vein (Figure 2A), with stenosis at the clavicle-first rib junction. Brain CT demonstrated calcifications in the cerebellar dentate nuclei and globus pallidus (Figure 2B). Serologic markers (antinuclear, anti-dsDNA, anti-β2 glycoprotein I, anticardiolipin) and hypocomplementemia confirmed systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS). The patient fulfilled the 2012 Systemic Lupus International Collaborating Clinics classification criteria, 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for SLE, and 2006 revised Sapporo classification criteria for APS, confirmed upper extremity deep vein thrombosis (UEDVT), APS, and SLE.</p><p>Percutaneous balloon angioplasty and aspiration thrombectomy were performed, followed by anticoagulation with warfarin. Corticosteroids, mizoribine, and hydroxychloroquine were initiated for SLE-associated leukopenia, resulting in clinical improvement without symptom recurrence.</p><p>UEDVT accounts for ~10% of DVT cases in Western countries but only 3% in Japan.<span><sup>1, 2</sup></span> Common symptoms include upper extremity discomfort, swelling, and superficial venous dilatation.<span><sup>1</sup></span> UEDVT is classified as primary (e.g., venous thoracic outlet syndrome and Paget-Schroetter syndrome) or secondary (e.g., central venous catheters, malignancy, trauma, pregnancy, and oral contraceptive use).<span><sup>1</sup></span> In this case, extrinsic compression of the left subclavian vein at the costoclavicular junction, combined with prolonged immobility followed by vigorous upper extremity activity, contributed to venous thoracic outlet syndrome and Paget-Schroetter syndrome, which increased the risk of UEDVT.</p><p>D-dimer measurement is a valuable diagnostic tool for suspected UEDVT. In this patient, D-dimer (0.9 μ/mL) was within institutional reference limits but mildly elevated under Western cut-offs (0.5 μ/mL). When the pre-test probability of venous thromboembolism is high, the negative predictive value
一个35岁的妇女癫痫和不孕症提出了2天的历史左上肢肿胀。症状开始于旅行后,可能是由于长时间不活动,随后上肢剧烈活动和左臂上皮包的压力,导致静脉淤积。她还报告说,在过去的6个月里,她经常头痛。患者正在服用左乙拉西坦、拉莫三嗪、叶酸和洛索洛芬,这些药物均与血栓形成风险无关。检查时,左上肢肿胀(图1A),浅表静脉扩张延伸至胸部(图1B)。实验室结果显示白细胞减少,淋巴细胞减少,活化的部分凝血活素时间延长,d -二聚体水平为0.9 μ/mL(参考文献1.0 μ/mL)。胸部增强计算机断层扫描(CT)显示左腋至锁骨下静脉血栓形成(图2A),锁骨-第一肋骨连接处狭窄。脑部CT显示小脑齿状核和苍白球钙化(图2B)。血清学指标(抗核、抗dsdna、抗β2糖蛋白I、抗心磷脂)和低补体血症证实系统性红斑狼疮(SLE)和抗磷脂抗体综合征(APS)。患者符合2012年系统性狼疮国际合作诊所分类标准,2019年欧洲抗风湿病联盟/美国风湿病学会SLE分类标准,2006年修订的Sapporo APS分类标准,确认上肢深静脉血栓形成(UEDVT), APS和SLE。经皮球囊血管成形术和吸入性取栓术,并用华法林抗凝。糖皮质激素、米佐利滨和羟氯喹治疗sle相关白细胞减少症,临床改善,无症状复发。UEDVT在西方国家约占DVT病例的10%,而在日本仅占3%。1,2常见症状为上肢不适、肿胀、浅静脉扩张UEDVT分为原发性(如胸廓出口静脉综合征和Paget-Schroetter综合征)和继发性(如中心静脉置管、恶性肿瘤、创伤、妊娠和口服避孕药)在本例中,左侧锁骨下静脉在肋锁骨连接处的外源性压迫,加上长时间不活动,随后上肢剧烈活动,导致静脉胸廓出口综合征和Paget-Schroetter综合征,这增加了UEDVT的风险。d -二聚体测量是诊断疑似UEDVT的重要工具。在该患者中,d -二聚体(0.9 μ/mL)在机构参考范围内,但在西方截止值(0.5 μ/mL)下轻度升高。当检测前静脉血栓栓塞的概率较高时,d -二聚体的阴性预测值降低,增加假阴性结果的风险。在这种情况下,建议进行影像学检查虽然罕见,但UEDVT可能是APS或SLE的初始表现。APS是SLE的常见并发症,表现为静脉或动脉血栓形成,特别是有不孕史的年轻女性神经精神性SLE (NPSLE)分为中枢型和外周型。中枢性NPSLE可表现为局灶性症状,如头痛(28.3%)、癫痫(20.0%)和脑血管疾病(15.0%),影像学表现如基底节区和小脑钙化是这种疾病的标志性表现在同侧上肢肿胀和浅静脉扩张的患者中应怀疑UEDVT。在本例中,UEDVT和颅内钙化的共存有力地支持了SLE APS的诊断。Masahiro Yabe:概念化;写作——原稿;方法;项目管理;数据管理;调查。Ozaki Nozomi:概念化;写作——原稿;数据管理;调查。佐藤信宏:监督;写作——审阅和编辑。中村德仁:监督;写作——审阅和编辑。青山Azusa:监督;写作——审阅和编辑。村上春树:监督;写作——审阅和编辑。广濑康夫:监督;写作——审阅和编辑。作者声明与本文无关的利益冲突。不适用。发表本报告已获得患者的书面同意。
{"title":"Upper extremity deep vein thrombosis associated with systemic lupus erythematosus and antiphospholipid syndrome","authors":"Masahiro Yabe MD,&nbsp;Nozomi Ozaki MD,&nbsp;Nobuhiro Sato MD, MPH, PhD,&nbsp;Norihito Nakamura MD, PhD,&nbsp;Azusa Aoyama MD,&nbsp;Shuichi Murakami MD, PhD,&nbsp;Yasuo Hirose MD","doi":"10.1002/jgf2.70023","DOIUrl":"https://doi.org/10.1002/jgf2.70023","url":null,"abstract":"&lt;p&gt;A 35-year-old woman with epilepsy and infertility presented with a 2-day history of left upper extremity swelling. Symptoms began after traveling, likely due to prolonged immobility followed by vigorous upper extremity activity and pressure from a leather bag on the left arm, contributing to venous stasis. She also reported experiencing recurrent headaches over the past 6 months. The patient was taking levetiracetam, lamotrigine, folic acid, and loxoprofen, none of which are associated with thrombotic risk. On examination, the left upper extremity exhibited swelling (Figure 1A) and superficial venous dilatation extending to the chest (Figure 1B). Laboratory findings demonstrated leukopenia, lymphopenia, a prolonged activated partial thromboplastin time, and a D-dimer level of 0.9 μ/mL (reference &lt;1.0 μ/mL).&lt;/p&gt;&lt;p&gt;Chest contrast-enhanced computed tomography (CT) revealed thrombosis in the left axillary to the subclavian vein (Figure 2A), with stenosis at the clavicle-first rib junction. Brain CT demonstrated calcifications in the cerebellar dentate nuclei and globus pallidus (Figure 2B). Serologic markers (antinuclear, anti-dsDNA, anti-β2 glycoprotein I, anticardiolipin) and hypocomplementemia confirmed systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome (APS). The patient fulfilled the 2012 Systemic Lupus International Collaborating Clinics classification criteria, 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for SLE, and 2006 revised Sapporo classification criteria for APS, confirmed upper extremity deep vein thrombosis (UEDVT), APS, and SLE.&lt;/p&gt;&lt;p&gt;Percutaneous balloon angioplasty and aspiration thrombectomy were performed, followed by anticoagulation with warfarin. Corticosteroids, mizoribine, and hydroxychloroquine were initiated for SLE-associated leukopenia, resulting in clinical improvement without symptom recurrence.&lt;/p&gt;&lt;p&gt;UEDVT accounts for ~10% of DVT cases in Western countries but only 3% in Japan.&lt;span&gt;&lt;sup&gt;1, 2&lt;/sup&gt;&lt;/span&gt; Common symptoms include upper extremity discomfort, swelling, and superficial venous dilatation.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; UEDVT is classified as primary (e.g., venous thoracic outlet syndrome and Paget-Schroetter syndrome) or secondary (e.g., central venous catheters, malignancy, trauma, pregnancy, and oral contraceptive use).&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; In this case, extrinsic compression of the left subclavian vein at the costoclavicular junction, combined with prolonged immobility followed by vigorous upper extremity activity, contributed to venous thoracic outlet syndrome and Paget-Schroetter syndrome, which increased the risk of UEDVT.&lt;/p&gt;&lt;p&gt;D-dimer measurement is a valuable diagnostic tool for suspected UEDVT. In this patient, D-dimer (0.9 μ/mL) was within institutional reference limits but mildly elevated under Western cut-offs (0.5 μ/mL). When the pre-test probability of venous thromboembolism is high, the negative predictive value","PeriodicalId":51861,"journal":{"name":"Journal of General and Family Medicine","volume":"26 6","pages":"652-654"},"PeriodicalIF":2.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jgf2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to promote female medical leaders? Insights and solutions from the JACRA Chief Resident Meeting 如何提升女性医学领袖?来自JACRA首席驻地会议的见解和解决方案
IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-04-17 DOI: 10.1002/jgf2.70022
Masumi Ogushi MD, Kazuya Nagasaki MD, PhD, Toshinori Nishizawa MD, Yuko Murashima MD, Kosuke Tanaka MD, Takuma Hata MD, Masayuki Nogi MD, MHPE, FACP
<p>Reports from the United States underscore the vital role of chief residents in clinical practice and medical education, serving as leaders for their fellow residents.<span><sup>1</sup></span> While early leadership experience offers numerous benefits, a significant challenge persists in Japan: leadership positions remain predominantly held by men. Beyond leadership roles, Japan grapples with a pervasive gender gap within its medical field. For instance, the proportion of female physicians in Japan is the lowest among OECD countries, standing at just 23.6%.<span><sup>2</sup></span> This leadership disparity extends across hospital executive boards, professional societies, and academic institutions, limiting diversity at decision-making levels.</p><p>At the JACRA (Japan Chief Resident Association) Chief Resident Meeting in March 2024, about 40 current and incoming chief residents convened to discuss two key questions: “Why are there so few female leaders?” and “What actions are necessary to foster gender-diverse leadership?” To encourage candid feedback, an anonymous online polling system was utilized. Table 1 presents a categorization of audience responses. Results highlighted key challenges such as work-life balance struggles and inadequate leadership training. Many participants emphasized the unequal distribution of clinical and administrative workloads among female leaders. This letter presents insights from the discussion and potential solutions to advance gender equity.</p><p>Participants noted that traits such as modesty and humility, often associated with women, contribute to their hesitation in assuming leadership roles. The “imposter phenomenon,” characterized by a tendency to underestimate one's abilities, was also frequently mentioned.<span><sup>3</sup></span> These observations underscore deep-rooted biases affecting leadership perceptions and career advancement.</p><p>The physical demands on women and their career impact were recurring themes. Mid-career breaks due to childbirth and childcare responsibilities pose major obstacles, affecting promotion opportunities. Matsui et al. found that female medical students prioritize family-career balance when making career choices, whereas male students focus on work initially and adjust later.<span><sup>4</sup></span> </p><p>Systemic barriers also hinder women's advancement. Female leaders often face excessive clinical and administrative workloads, compounded by insufficient institutional support. Limited networking opportunities and lack of visibility within professional circles further exacerbate these challenges, making career progression more difficult.</p><p>Addressing these issues requires a comprehensive, multi-pronged approach. Institutions must take proactive steps to increase female representation in leadership. Establishing mentorship programs, particularly group mentorship, can foster confidence, skill development, and career progression. Systemic reforms such as pr
来自美国的报告强调了总住院医师在临床实践和医学教育中的重要作用,他们是其他住院医师的领导者虽然早期的领导经验给女性带来了很多好处,但日本仍然存在一个重大挑战:领导职位仍然主要由男性担任。除了领导角色,日本还在努力解决医疗领域普遍存在的性别差距问题。例如,日本女医生的比例是经合组织国家中最低的,仅为23.6%这种领导力差异在医院执行委员会、专业协会和学术机构中普遍存在,限制了决策层面的多样性。在2024年3月举行的日本总住院医师协会(JACRA)总住院医师会议上,约40名现任和即将上任的总住院医师聚集在一起,讨论了“为什么女性领导者这么少”和“为了培养性别多元化的领导力,需要采取哪些行动”这两个关键问题。为了鼓励坦率的反馈,采用了匿名在线投票系统。表1给出了听众反应的分类。调查结果突出了一些关键挑战,如工作与生活的平衡问题和领导力培训不足。许多与会者强调,临床和行政工作量在女性领导人之间的分配不平等。这封信提出了讨论中的见解和促进性别平等的潜在解决方案。与会者指出,谦虚和谦逊等通常与女性有关的特质,导致她们在担任领导角色时犹豫不决。以低估自己能力为特征的“冒名顶替者现象”也经常被提及这些观察结果强调了影响领导力认知和职业发展的根深蒂固的偏见。对妇女的体力要求及其对职业的影响是反复出现的主题。由于生育和照顾孩子的责任而导致的职业中期中断是主要障碍,影响晋升机会。Matsui et al.发现女医学生在职业选择时优先考虑家庭与事业的平衡,而男医学生在职业选择时优先考虑工作,然后再进行调整体制障碍也阻碍了妇女的进步。女性领导人往往面临过多的临床和行政工作量,加上机构支持不足。有限的社交机会和在专业圈子中缺乏知名度进一步加剧了这些挑战,使职业发展更加困难。解决这些问题需要采取综合、多管齐下的办法。各机构必须采取积极措施,增加女性在领导层中的代表性。建立师徒关系项目,特别是团体师徒关系,可以培养信心、技能发展和职业发展。促进家庭责任分担、扩大男性育儿假和防止过度工作等系统性改革至关重要。通过实施协作式领导模式和减轻行政负担来重组领导角色,也将使领导者专注于核心责任和专业成长。研究表明,在医疗保健领域实行性别多样化的领导是有益的。Naciti et al.(2022)发现,女性领导越多的医院财务绩效越好,效率越高,决策能力也越好这些调查结果强调需要促进性别多样性,以提高保健质量和效率。JACRA继续致力于通过有针对性的领导力教育和培训举措来支持这些努力。通过解决系统性障碍、加强指导和促进包容性,我们的目标是赋予妇女权力,使她们能够发挥领导作用,贡献她们的专业知识,推动医疗行业发生有意义的变化。这项工作尚未发表。Masumi Ogushi:写作-原稿;写作——审阅和编辑;资源;项目管理;可视化;概念化;方法;调查。长崎和也:监督;写作——审阅和编辑;项目管理。西泽俊典:概念化;调查;监督;项目管理;写作——审阅和编辑;方法。村岛裕子:调查;概念化。田中kosuke:概念化;调查。Takuma Hata:概念化;调查;方法;监督;项目管理。野木雅之:写作-评论和编辑;资源;项目管理。这封信没有得到外部或内部的资金支持。作者无利益冲突需要申报。我们确认已从图的主体处获得发表的同意。
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引用次数: 0
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Journal of General and Family Medicine
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