Pub Date : 2019-03-31DOI: 10.18287/jbpe19.05.010001
O. Myakinin
{"title":"Issue Info: J of Biomedical Photonics & Eng 5(1)","authors":"O. Myakinin","doi":"10.18287/jbpe19.05.010001","DOIUrl":"https://doi.org/10.18287/jbpe19.05.010001","url":null,"abstract":"","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46420668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-31DOI: 10.18287/jbpe19.05.010000
O. Myakinin
{"title":"Cover: Special Issue. Years in Optoacoustics: 70-th Anniversary of Prof. Vladimir P. Zharov","authors":"O. Myakinin","doi":"10.18287/jbpe19.05.010000","DOIUrl":"https://doi.org/10.18287/jbpe19.05.010000","url":null,"abstract":"","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":"52 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41266149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.18287/JBPE19.05.010305
A. Belikov, A. D. Tavalinskaya, S. Smirnov, A. N. Sergeev
The paper discusses the active delivery of a drug (methylene blue solution) through the Er:YLF-laser-perforated nail plate using pulsed radiation of microsecond Yb,Er:Glass laser. Different methods of laser impact on liquid drug are considered: by focused and diverging laser beam. It was established that both discussed methods can provide sufficient dose of the drug for the treatment of onychomycosis.
{"title":"Application of Yb,Er:Glass laser radiation for active drug delivery at the treatment of onychomycosis","authors":"A. Belikov, A. D. Tavalinskaya, S. Smirnov, A. N. Sergeev","doi":"10.18287/JBPE19.05.010305","DOIUrl":"https://doi.org/10.18287/JBPE19.05.010305","url":null,"abstract":"The paper discusses the active delivery of a drug (methylene blue solution) through the Er:YLF-laser-perforated nail plate using pulsed radiation of microsecond Yb,Er:Glass laser. Different methods of laser impact on liquid drug are considered: by focused and diverging laser beam. It was established that both discussed methods can provide sufficient dose of the drug for the treatment of onychomycosis.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46147594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-29DOI: 10.18287/JBPE19.05.010304
B. Ageev, O. Nikiforova, Y. Ponomarev, V. Sapozhnikova
A possibility of detecting biogenic gases by the laser optoacoustic gas-analysis method is shown. The construction and specifications of instruments, developed for this purpose, are described. Examples of the analysis of gas samples of various biological objects, like air, expired by patients, suffered from different illnesses, and residual gases in the wood of year rings of conifers are given together with recommendations on applying the received information.
{"title":"Optoacoustic gas-analysis for diagnostics of biosystems","authors":"B. Ageev, O. Nikiforova, Y. Ponomarev, V. Sapozhnikova","doi":"10.18287/JBPE19.05.010304","DOIUrl":"https://doi.org/10.18287/JBPE19.05.010304","url":null,"abstract":"A possibility of detecting biogenic gases by the laser optoacoustic gas-analysis method is shown. The construction and specifications of instruments, developed for this purpose, are described. Examples of the analysis of gas samples of various biological objects, like air, expired by patients, suffered from different illnesses, and residual gases in the wood of year rings of conifers are given together with recommendations on applying the received information.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68178266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-28DOI: 10.18287/JBPE19.05.010303
Y. Kistenev, A. Borisov, V. Nikolaev, D. Vrazhnov, D. А. Kuzmin
The breathomics approach to express-diagnosis of bronchopulmonary diseases based on spectral analysis of volatile organic compounds in a patient’s exhaled air is discussed. The basic demands and possible technical solutions to laser photoacoustic spectroscopy equipment in a framework of breathomics are presented. An example of differential diagnostics of the set of bronchopulmonary diseases, including lung cancer (LC) patients (N = 9); patients with chronic obstructive pulmonary disease (COPD) (N = 12); patients with pneumonia (N = 11) and a control group of healthy volunteers using breath air analysis by laser photoacoustic spectroscopy and machine learning is presented.
{"title":"Laser photoacoustic spectroscopy applications in breathomics","authors":"Y. Kistenev, A. Borisov, V. Nikolaev, D. Vrazhnov, D. А. Kuzmin","doi":"10.18287/JBPE19.05.010303","DOIUrl":"https://doi.org/10.18287/JBPE19.05.010303","url":null,"abstract":"The breathomics approach to express-diagnosis of bronchopulmonary diseases based on spectral analysis of volatile organic compounds in a patient’s exhaled air is discussed. The basic demands and possible technical solutions to laser photoacoustic spectroscopy equipment in a framework of breathomics are presented. An example of differential diagnostics of the set of bronchopulmonary diseases, including lung cancer (LC) patients (N = 9); patients with chronic obstructive pulmonary disease (COPD) (N = 12); patients with pneumonia (N = 11) and a control group of healthy volunteers using breath air analysis by laser photoacoustic spectroscopy and machine learning is presented.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44297687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-27DOI: 10.18287/JBPE19.05.010302
N. Chernomyrdin, Anastasiya D. Lesnichaya, E. V. Yakovlev, K. Kudrin, O. Cherkasova, E. N. Rimskaya, V. Kurlov, V. Karasik, I. Reshetov, V. Tuchin, K. Zaytsev
An approach for differentiating basal cell carcinoma (BCC) and healthy skin by combining a multispectral modulation autofluorescence imaging with the linear discriminant analysis has been proposed. The experimental setup, which employs a 365-nm narrowband excitation, 4 replaceable bandpass filters and a digital camera, has been assembled and applied to study freshly excised samples of BCC. In the experimental setup, modulation of the UV-excitation and demodulation of the visible light images allow for both increasing a signal-to-noise ratio and suppressing a non-fluorescence background in the autofluorescence images of tissues. The observed results demonstrate an ability for distinguishing both ordinary and keratinized BCC from healthy skin justifying the perspectives of the multispectral modulation autofluorescence imaging use for non-invasive and intraoperative diagnosis of BCC and other low-pigmented malignancies of the skin.
{"title":"Differentiation of basal cell carcinoma and healthy skin using multispectral modulation autofluorescence imaging: A pilot study","authors":"N. Chernomyrdin, Anastasiya D. Lesnichaya, E. V. Yakovlev, K. Kudrin, O. Cherkasova, E. N. Rimskaya, V. Kurlov, V. Karasik, I. Reshetov, V. Tuchin, K. Zaytsev","doi":"10.18287/JBPE19.05.010302","DOIUrl":"https://doi.org/10.18287/JBPE19.05.010302","url":null,"abstract":"An approach for differentiating basal cell carcinoma (BCC) and healthy skin by combining a multispectral modulation autofluorescence imaging with the linear discriminant analysis has been proposed. The experimental setup, which employs a 365-nm narrowband excitation, 4 replaceable bandpass filters and a digital camera, has been assembled and applied to study freshly excised samples of BCC. In the experimental setup, modulation of the UV-excitation and demodulation of the visible light images allow for both increasing a signal-to-noise ratio and suppressing a non-fluorescence background in the autofluorescence images of tissues. The observed results demonstrate an ability for distinguishing both ordinary and keratinized BCC from healthy skin justifying the perspectives of the multispectral modulation autofluorescence imaging use for non-invasive and intraoperative diagnosis of BCC and other low-pigmented malignancies of the skin.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68178149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-09DOI: 10.18287/JBPE19.05.010301
A. Pandya, J. Kumaradas, A. Douplik
In this study, we present facile fabrication of a miniaturized remote sensing SERS platform using highly tunable Nano-Sphere Lithography (NSL) technique. Using 200 μm diameter optical fibers with high numerical aperture (0.5NA), the SERS enhancement of remote sensing was found to be 98% of direct sensing configuration. Standard silica optical fibers were used for remote sensing using SERS without additional need of optical filtering to mitigate fluorescence and Raman background of these fibers which allows fabrication of miniaturized remote sensing platforms that can be used for remote biochemical sensing.
{"title":"Miniature optical fiber sensors using surface enhanced Raman spectroscopy (SERS) for remote biochemical sensing","authors":"A. Pandya, J. Kumaradas, A. Douplik","doi":"10.18287/JBPE19.05.010301","DOIUrl":"https://doi.org/10.18287/JBPE19.05.010301","url":null,"abstract":"In this study, we present facile fabrication of a miniaturized remote sensing SERS platform using highly tunable Nano-Sphere Lithography (NSL) technique. Using 200 μm diameter optical fibers with high numerical aperture (0.5NA), the SERS enhancement of remote sensing was found to be 98% of direct sensing configuration. Standard silica optical fibers were used for remote sensing using SERS without additional need of optical filtering to mitigate fluorescence and Raman background of these fibers which allows fabrication of miniaturized remote sensing platforms that can be used for remote biochemical sensing.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46617118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.18287/jbpe18.04.040201
E. Naumova, A. Naumova, D. Isaev, I. Volodyaev
The review is devoted to the experimental studies of mitogenetic radiation (weak UV-chemiluminescence of biological objects) conducted between 1923 and 1948 years. In this period UV-radiation of various biological objects (so called inductors) and its influence on mitotic rate of other biological objects (detectors) were investigated very actively. Very promising results were obtained including the finding of the peptide tumor marker in blood, which was called cancer quencher due to its ability to quench UV-chemiluminescence of blood. Later these researches were interrupted and almost abandoned. The relevance of the scientific problems addressed in these works to this day is stated, the key experiments and the most valuable results obtained between 1923 and 1948 are described in details and subsequent researches are briefly traced up to the present. The prospects of future development are discussed.
{"title":"Historical review of early researches on mitogenetic radiation: from discovery to cancer diagnostics","authors":"E. Naumova, A. Naumova, D. Isaev, I. Volodyaev","doi":"10.18287/jbpe18.04.040201","DOIUrl":"https://doi.org/10.18287/jbpe18.04.040201","url":null,"abstract":"The review is devoted to the experimental studies of mitogenetic radiation (weak UV-chemiluminescence of biological objects) conducted between 1923 and 1948 years. In this period UV-radiation of various biological objects (so called inductors) and its influence on mitotic rate of other biological objects (detectors) were investigated very actively. Very promising results were obtained including the finding of the peptide tumor marker in blood, which was called cancer quencher due to its ability to quench UV-chemiluminescence of blood. Later these researches were interrupted and almost abandoned. The relevance of the scientific problems addressed in these works to this day is stated, the key experiments and the most valuable results obtained between 1923 and 1948 are described in details and subsequent researches are briefly traced up to the present. The prospects of future development are discussed.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46558203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-31DOI: 10.18287/JBPE18.04.040301
I. Bratchenko, O. Myakinin, V. P. Sherendak, P. Volkhin, Y. Khristoforova, L. Bratchenko, D. Artemyev, A. Moryatov, O. Polschikova, A. Machikhin, V. Pozhar, S. Kozlov, V. Zakharov
We present results of main skin chromophores (melanin and hemoglobin) optical analysis. Analysis of 91 in vivo skin tissues (50 benign and 41 malignant) was performed in visible spectral region with hyperspectral imaging technique. To assess the malignancy of skin tissues we proposed two methods for calculating the integral index of tissue optical density and performed a comparison of their effectiveness and effectiveness of physician survey. As the main diagnostic feature, we propose to use data of integral optical index dispersion from the studied tissue and healthy tissue area. The results of skin tissues classification with discriminant analysis are presented. The possibility of the proposed approaches application in the clinical practice is shown.
{"title":"In vivo hyperspectral analysis of skin hemoglobin and melanin content for neoplasia detection","authors":"I. Bratchenko, O. Myakinin, V. P. Sherendak, P. Volkhin, Y. Khristoforova, L. Bratchenko, D. Artemyev, A. Moryatov, O. Polschikova, A. Machikhin, V. Pozhar, S. Kozlov, V. Zakharov","doi":"10.18287/JBPE18.04.040301","DOIUrl":"https://doi.org/10.18287/JBPE18.04.040301","url":null,"abstract":"We present results of main skin chromophores (melanin and hemoglobin) optical analysis. Analysis of 91 in vivo skin tissues (50 benign and 41 malignant) was performed in visible spectral region with hyperspectral imaging technique. To assess the malignancy of skin tissues we proposed two methods for calculating the integral index of tissue optical density and performed a comparison of their effectiveness and effectiveness of physician survey. As the main diagnostic feature, we propose to use data of integral optical index dispersion from the studied tissue and healthy tissue area. The results of skin tissues classification with discriminant analysis are presented. The possibility of the proposed approaches application in the clinical practice is shown.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46081781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-30DOI: 10.18287/JBPE18.04.030303
P. Ermolinskiy, A. Lugovtsov, A. I. Maslyanitsina, A. Semenov, L. Dyachuk, A. Priezzhev
Two-channel laser tweezers are used to measure the interaction kinetics of two erythrocytes at the initial stage of aggregation, i.e., the formation of a pair aggregate in vitro. The study of erythrocytes interaction is important both for understanding the fundamental aggregation mechanisms and for evaluating the differences in kinetics and dynamics of aggregation, depending on the presence or absence of diseases that disturb the blood flow parameters and, therefore, the oxygen supply to tissues. We analyse the kinetics and dynamics of pair aggregation of erythrocytes in blood samples from more than 60 patients with arterial hypertension, as well as from a group of healthy donors. The results show that both kinetics and dynamics of erythrocyte aggregation are changed in the presence of the considered pathology.
{"title":"Interaction of erythrocytes in the process of pair aggregation in blood samples from patients with arterial hypertension and healthy donors: measurements with laser tweezers","authors":"P. Ermolinskiy, A. Lugovtsov, A. I. Maslyanitsina, A. Semenov, L. Dyachuk, A. Priezzhev","doi":"10.18287/JBPE18.04.030303","DOIUrl":"https://doi.org/10.18287/JBPE18.04.030303","url":null,"abstract":"Two-channel laser tweezers are used to measure the interaction kinetics of two erythrocytes at the initial stage of aggregation, i.e., the formation of a pair aggregate in vitro. The study of erythrocytes interaction is important both for understanding the fundamental aggregation mechanisms and for evaluating the differences in kinetics and dynamics of aggregation, depending on the presence or absence of diseases that disturb the blood flow parameters and, therefore, the oxygen supply to tissues. We analyse the kinetics and dynamics of pair aggregation of erythrocytes in blood samples from more than 60 patients with arterial hypertension, as well as from a group of healthy donors. The results show that both kinetics and dynamics of erythrocyte aggregation are changed in the presence of the considered pathology.","PeriodicalId":52398,"journal":{"name":"Journal of Biomedical Photonics and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47071225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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