Sarah Gondek, Mateusz Ogledzinski, William Lin, Kamila Milejczyk, Braden Juengel, Lisa Potter, Piotr J Bachul, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Zuzanna Witkowska, Rolf Barth, John Fung, Piotr Witkowski
Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.
{"title":"Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies.","authors":"Sarah Gondek, Mateusz Ogledzinski, William Lin, Kamila Milejczyk, Braden Juengel, Lisa Potter, Piotr J Bachul, Lindsay Basto, Laurencia Perea, Ling-Jia Wang, Martin Tibudan, Zuzanna Witkowska, Rolf Barth, John Fung, Piotr Witkowski","doi":"10.31373/ejtcm/166178","DOIUrl":"https://doi.org/10.31373/ejtcm/166178","url":null,"abstract":"<p><p>Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.</p>","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485871/pdf/nihms-1911385.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10293973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-23DOI: 10.24018/clinicmed.2022.3.6.220
Ş. Dokcu, M. Çaparlar, S. Basceken, A. Eroğlu
Purpose: Today, racial/ethnic differences in the incidence and prognosis of breast cancer (BC) are a well-known fact. This study aimed to examine the distribution of BC molecular subtypes in Turkish women and their relationship with other prognostic clinicopathological variables. Methods: In our surgical oncology clinic, the database of 480 BC cases was retrospectively scanned between January 2008 and December 2020, and the demographic and histopathological results of the patients were recorded. Patients were classified into five main molecular subtypes. Survival curves were estimated using the Kaplan – Meier method. The relationship between categorical variables was analyzed using the chisquare test. Results: The mean age of the patients at the time of diagnosis was 54.5 years, 46.3% were premenopausal, the mean tumor size was 28.7 mm, most of them were T1 (54%), ER, PR, HER-2 positivity rates were 79.6%, 73.1%, 38.3%, respectively and Ki-67 index average was 31.6. The most common molecular subtype was Luminal B Her2B-(33.5%). During a mean follow-up period of 56.9 months, 5 and 10-year overall survival (OS) rates were 89.5%, 79.6%, respectively, and disease-free survival (DFS) rates were 86.9%, 70.5%, respectively. The recurrence rate was 12.3%, distribution by molecular subtypes was significant (p=0.02). Luminal A and Luminal B/Her2- were in relation with Lobular Carcinoma (p=0.005), low histological grade (p=0.00), small tumor size (p=0.00), absence of lymphovascular invasion (LVI) (p=0.00), breast conserving surgery (p=0.022), presence of menopause (p =0.005) and local disease (p =0.013). Conclusions: This study showed that there are differences in molecular subtyping for symptomatic BC in Turkish women.
目的:今天，乳腺癌(BC)的发病率和预后的种族/民族差异是一个众所周知的事实。本研究旨在研究BC分子亚型在土耳其妇女中的分布及其与其他预后临床病理变量的关系。方法:对我院肿瘤外科门诊2008年1月至2020年12月480例BC病例数据库进行回顾性扫描，记录患者的人口统计学和组织病理学结果。患者被分为5个主要的分子亚型。使用Kaplan - Meier方法估计生存曲线。分类变量间的关系采用chissquare检验进行分析。结果:患者确诊时平均年龄54.5岁，绝经前46.3%，平均肿瘤大小28.7 mm，以T1(54%)居多，ER、PR、HER-2阳性率分别为79.6%、73.1%、38.3%，Ki-67指数平均值为31.6。最常见的分子亚型是Luminal B Her2B-(33.5%)。平均随访56.9个月，5年和10年总生存率(OS)分别为89.5%、79.6%，无病生存率(DFS)分别为86.9%、70.5%。复发率为12.3%，分子分型差异有统计学意义(p=0.02)。管腔A和管腔B/Her2-与小叶癌(p=0.005)、低组织学分级(p=0.00)、小肿瘤大小(p=0.00)、无淋巴血管侵犯(LVI) (p=0.00)、保乳手术(p=0.022)、绝经(p=0.005)和局部疾病(p= 0.013)有关。结论:本研究表明，土耳其妇女症状性BC的分子分型存在差异。
{"title":"Distribution and Clinicopathological Characteristics of Breast Cancer Molecular Subtypes in Turkish Women","authors":"Ş. Dokcu, M. Çaparlar, S. Basceken, A. Eroğlu","doi":"10.24018/clinicmed.2022.3.6.220","DOIUrl":"https://doi.org/10.24018/clinicmed.2022.3.6.220","url":null,"abstract":"\u0000Purpose: Today, racial/ethnic differences in the incidence and prognosis of breast cancer (BC) are a well-known fact. This study aimed to examine the distribution of BC molecular subtypes in Turkish women and their relationship with other prognostic clinicopathological variables.\u0000\u0000\u0000Methods: In our surgical oncology clinic, the database of 480 BC cases was retrospectively scanned between January 2008 and December 2020, and the demographic and histopathological results of the patients were recorded. Patients were classified into five main molecular subtypes. Survival curves were estimated using the Kaplan – Meier method. The relationship between categorical variables was analyzed using the chisquare test.\u0000\u0000\u0000Results: The mean age of the patients at the time of diagnosis was 54.5 years, 46.3% were premenopausal, the mean tumor size was 28.7 mm, most of them were T1 (54%), ER, PR, HER-2 positivity rates were 79.6%, 73.1%, 38.3%, respectively and Ki-67 index average was 31.6. The most common molecular subtype was Luminal B Her2B-(33.5%). During a mean follow-up period of 56.9 months, 5 and 10-year overall survival (OS) rates were 89.5%, 79.6%, respectively, and disease-free survival (DFS) rates were 86.9%, 70.5%, respectively. The recurrence rate was 12.3%, distribution by molecular subtypes was significant (p=0.02). Luminal A and Luminal B/Her2- were in relation with Lobular Carcinoma (p=0.005), low histological grade (p=0.00), small tumor size (p=0.00), absence of lymphovascular invasion (LVI) (p=0.00), breast conserving surgery (p=0.022), presence of menopause (p =0.005) and local disease (p =0.013).\u0000\u0000\u0000Conclusions: This study showed that there are differences in molecular subtyping for symptomatic BC in Turkish women.\u0000","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77086061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Subcutaneous cardioveter-defibrillator (S-ICD) gained considerable place in sudden cardiac death (SCD) preven - tion. The main advantage of this device is the possiblility of implantating it outside of blood vessel. The lack of permanent pacing and antitachycardia pacing (ATP) are its key limitations. New research is focused on creating an extravessel device that could combine the role of cardioverter and pacemaker. The main difficulty is the mutual interference of sensing
{"title":"Advantages, limitations and new perspectives on the implantation of subcutaneous cardioverter-defibrillator","authors":"B. Opielowska-Nowak, G. Raczak, Martyna Badyoczek","doi":"10.31373/ejtcm/156835","DOIUrl":"https://doi.org/10.31373/ejtcm/156835","url":null,"abstract":"Subcutaneous cardioveter-defibrillator (S-ICD) gained considerable place in sudden cardiac death (SCD) preven - tion. The main advantage of this device is the possiblility of implantating it outside of blood vessel. The lack of permanent pacing and antitachycardia pacing (ATP) are its key limitations. New research is focused on creating an extravessel device that could combine the role of cardioverter and pacemaker. The main difficulty is the mutual interference of sensing","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46672277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iyshwarya Bhaskar Kalarani, Ramakrishnan Veerabathiran, Vajagathali Mohammed
Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. PE is a leading cause of maternal death, with about 55000 deaths worldwide each year. Toxic substances that damage the maternal vascular endothelium induce PE, resul - ting in liver and kidney malfunction. It is crucial for obstetricians to identify as early as possible the patients who are at risk for PE. Polycystic ovarian disease, sleeping disorders, urinary infections, periodontal disease, smoking, lifestyle and familial history of PE are the major risk factors involved in this disease. VEGF, sFlt1, sENG, PAPP-A, inhibin A and activin A proteins, fetal hemoglobin, heat shock protein and placental protein have been helpful in predicting or diagnosing PE and in understanding its pathogenesis. In addition, a better understanding of PE pathogenesis would aid in identifying the most effective treatments that do not impair the fetus’ prognosis. The aim of our study is a review of the pathophysiology and biomarkers, such as pro- and anti-angiogenic substan - ces, that may be useful in the detection of PE in the future
{"title":"The role of biomarkers in early prediction and molecular mechanisms of preeclampsia","authors":"Iyshwarya Bhaskar Kalarani, Ramakrishnan Veerabathiran, Vajagathali Mohammed","doi":"10.31373/ejtcm/156837","DOIUrl":"https://doi.org/10.31373/ejtcm/156837","url":null,"abstract":"Preeclampsia (PE) is defined as new onset hypertension after 20 weeks of gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. PE is a leading cause of maternal death, with about 55000 deaths worldwide each year. Toxic substances that damage the maternal vascular endothelium induce PE, resul - ting in liver and kidney malfunction. It is crucial for obstetricians to identify as early as possible the patients who are at risk for PE. Polycystic ovarian disease, sleeping disorders, urinary infections, periodontal disease, smoking, lifestyle and familial history of PE are the major risk factors involved in this disease. VEGF, sFlt1, sENG, PAPP-A, inhibin A and activin A proteins, fetal hemoglobin, heat shock protein and placental protein have been helpful in predicting or diagnosing PE and in understanding its pathogenesis. In addition, a better understanding of PE pathogenesis would aid in identifying the most effective treatments that do not impair the fetus’ prognosis. The aim of our study is a review of the pathophysiology and biomarkers, such as pro- and anti-angiogenic substan - ces, that may be useful in the detection of PE in the future","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44714707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Undrunas, A. Bąk, P. Kasprzyk, R. Dziedzic, D. Dziurda, W. Rzyman, M. Gierlotka, K. Kuziemski
Background: To improve the effectiveness of lung cancer screening using low-dose computed tomography (LDCT), the presence of smoking-related comorbidities that may significantly affect mortality in this group should be taken into account. Material and methods: A questionnaire survey and spirometry tests were conducted in a group of 730 respondents as part of a lung cancer screening study between 2016 and 2018. People diagnosed with COPD underwent a three-year follow-up to assess the incidence of medical events. Results: Our study confirmed that cardiovascular diseases (CVDs) were the most common comorbidities in patients who were dia - gnosed with COPD and participated in LDCT lung cancer screening. Among the CVDs, the most common were arterial hypertension (45.8%) and coronary artery disease (12.5%). Tobacco-related diseases (e.g. CVD, lung can - cer, and exacerbations of COPD) were the leading causes of emergency department visits and hospitalizations. The number of visits due to COPD in specialized clinics more than doubled in the observed period. Conclusions: Properly planned screening tests allow not only for the detection of the disease for which they were designed but also for the assessment of comorbidities. In patients undergoing lung cancer screening, it is justified to extend the diagnostics to include spirometry.
{"title":"Comorbidities and clinical outcomes of a lung cancer screening trial participants with chronic obstructive pulmonary disease in three-year follow-up","authors":"A. Undrunas, A. Bąk, P. Kasprzyk, R. Dziedzic, D. Dziurda, W. Rzyman, M. Gierlotka, K. Kuziemski","doi":"10.31373/ejtcm/153487","DOIUrl":"https://doi.org/10.31373/ejtcm/153487","url":null,"abstract":"Background: To improve the effectiveness of lung cancer screening using low-dose computed tomography (LDCT), the presence of smoking-related comorbidities that may significantly affect mortality in this group should be taken into account. Material and methods: A questionnaire survey and spirometry tests were conducted in a group of 730 respondents as part of a lung cancer screening study between 2016 and 2018. People diagnosed with COPD underwent a three-year follow-up to assess the incidence of medical events. Results: Our study confirmed that cardiovascular diseases (CVDs) were the most common comorbidities in patients who were dia - gnosed with COPD and participated in LDCT lung cancer screening. Among the CVDs, the most common were arterial hypertension (45.8%) and coronary artery disease (12.5%). Tobacco-related diseases (e.g. CVD, lung can - cer, and exacerbations of COPD) were the leading causes of emergency department visits and hospitalizations. The number of visits due to COPD in specialized clinics more than doubled in the observed period. Conclusions: Properly planned screening tests allow not only for the detection of the disease for which they were designed but also for the assessment of comorbidities. In patients undergoing lung cancer screening, it is justified to extend the diagnostics to include spirometry.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43565960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fast-tracking in cardiac care refers to the complex intervention including early extubation, care during anesthesia, mobilization and hospital discharge to reduce perioperative morbidity, costs, and length of stay in the intensive care unit and the hospital. This review was designed to evaluate early extubation protocols, the differences in early and late extubation, the safety and efficacy of early extubation among the patients in surgical intensive care after coronary artery bypass graft (CABG) surgery. The analyzed studies showed many significant differences in the mortality and postoperative complications of time-directed extubation practices and low dose-based general anesthesia in patients with low to moderate risk undergoing early extubation (fast-track) and the conventional care methods. Different fast-track interventions could diminish extubation time, costs, and the length of hospital stay. However, several factors including patient’s stay in the intensive therapy ward vs general ward, patient selection, skills and experience of the staff, and fast-track anesthesia methods could be considered to perform safe fast-tracking in patients undergoing cardiac surgery. On the other hand, to achieve this safety for high-risk cardiosurgery patients multidisciplinary coordination is needed.
{"title":"Early extubation protocol post-coronary artery bypass graft & open heart surgery","authors":"Mansour Jannati","doi":"10.31373/ejtcm/153486","DOIUrl":"https://doi.org/10.31373/ejtcm/153486","url":null,"abstract":"Fast-tracking in cardiac care refers to the complex intervention including early extubation, care during anesthesia, mobilization and hospital discharge to reduce perioperative morbidity, costs, and length of stay in the intensive care unit and the hospital. This review was designed to evaluate early extubation protocols, the differences in early and late extubation, the safety and efficacy of early extubation among the patients in surgical intensive care after coronary artery bypass graft (CABG) surgery. The analyzed studies showed many significant differences in the mortality and postoperative complications of time-directed extubation practices and low dose-based general anesthesia in patients with low to moderate risk undergoing early extubation (fast-track) and the conventional care methods. Different fast-track interventions could diminish extubation time, costs, and the length of hospital stay. However, several factors including patient’s stay in the intensive therapy ward vs general ward, patient selection, skills and experience of the staff, and fast-track anesthesia methods could be considered to perform safe fast-tracking in patients undergoing cardiac surgery. On the other hand, to achieve this safety for high-risk cardiosurgery patients multidisciplinary coordination is needed.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43684109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Szczerba, E. Koźluk, Łukasz Januszkiewicz, Monika Lisicka, J. Nowak, A. Kondracka, Joanna Majstrak, Dariusz Rodkiewicz, A. Piątkowska, M. Kiliszek, G. Opolski
Background: Concentration of tumor necrosis factor alpha (TNF-alpha) might be useful in selecting patients with paroxysmal atrial fibrillation (PAF) who will benefit the most from pulmonary vein isolation. Material and methods: This is a prospective cohort study among patients with PAF who had sinus rhythm prior to undergoing either radiofrequency ablation or cryoablation procedure. Blood samples were collected at the start of the procedure and 16-24 h after. TNF-alpha concentrations were measured. Follow-up data was obtained during a structured telephone interview and 24-hour ECG Holter monitoring 12 months after the ablation procedure. Results: Thirty seven patients were enrolled. After 12-month follow-up 27 patients maintained sinus rhythm, 8 had recurrence of AF and 2 were lost to follow-up. There was no significant correlation between TNF-alpha concentrations in any of the samples and the recurrence of arrhythmia (for pre-procedural samples: 1.75 pg/ ml vs. 1.74 pg/ml; p = 0.72; for post-procedural samples: 1.49 pg/ml vs. 1.79 pg/ml; p = 0.16). In patients who had a recurrence of AF, we observed a decrease in the periprocedural TNF-alpha concentration (-0.12 pg/ml vs 0.05 pg/ml; p = 0.05). Conclusions: Neither pre- nor post-procedural TNF-alpha concentrations are predictive of ablation outcome in patients with PAF. We observed a decrease in the periprocedural TNF-alpha concentration in patients who had AF recurrence.
{"title":"Periprocedural decrease in tumor necrosis factor alpha is a risk factor for atrial fibrillation recurrence after ablation","authors":"E. Szczerba, E. Koźluk, Łukasz Januszkiewicz, Monika Lisicka, J. Nowak, A. Kondracka, Joanna Majstrak, Dariusz Rodkiewicz, A. Piątkowska, M. Kiliszek, G. Opolski","doi":"10.31373/ejtcm/156997","DOIUrl":"https://doi.org/10.31373/ejtcm/156997","url":null,"abstract":"Background: Concentration of tumor necrosis factor alpha (TNF-alpha) might be useful in selecting patients with paroxysmal atrial fibrillation (PAF) who will benefit the most from pulmonary vein isolation. Material and methods: This is a prospective cohort study among patients with PAF who had sinus rhythm prior to undergoing either radiofrequency ablation or cryoablation procedure. Blood samples were collected at the start of the procedure and 16-24 h after. TNF-alpha concentrations were measured. Follow-up data was obtained during a structured telephone interview and 24-hour ECG Holter monitoring 12 months after the ablation procedure. Results: Thirty seven patients were enrolled. After 12-month follow-up 27 patients maintained sinus rhythm, 8 had recurrence of AF and 2 were lost to follow-up. There was no significant correlation between TNF-alpha concentrations in any of the samples and the recurrence of arrhythmia (for pre-procedural samples: 1.75 pg/ ml vs. 1.74 pg/ml; p = 0.72; for post-procedural samples: 1.49 pg/ml vs. 1.79 pg/ml; p = 0.16). In patients who had a recurrence of AF, we observed a decrease in the periprocedural TNF-alpha concentration (-0.12 pg/ml vs 0.05 pg/ml; p = 0.05). Conclusions: Neither pre- nor post-procedural TNF-alpha concentrations are predictive of ablation outcome in patients with PAF. We observed a decrease in the periprocedural TNF-alpha concentration in patients who had AF recurrence.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42155790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The theoretical and philosophical foundations of human well-being are well-described in psychology research. Within the construct of well-being, psychologists distinguish eudemonic positive affect and hedonic positive affect, although they are not only nor mutually exclusive approaches. Empirical findings demonstrate a correla - tion between the general positive affect and favorable health outcomes. Recent discoveries also show a biolo - gical pattern, which underlines the correlation. Thanks to describing the conserved transcriptional response to adversity (CTRA) mechanism, a new direction of research is emerging, exploring a relationship between profile of gene expression in immune cells and positive affect.
{"title":"Positive affect, well-being and the human conserved transcriptional response to adversity: a descriptive review","authors":"Michalina Frankowska, Magdalena Błażek","doi":"10.31373/ejtcm/152870","DOIUrl":"https://doi.org/10.31373/ejtcm/152870","url":null,"abstract":"The theoretical and philosophical foundations of human well-being are well-described in psychology research. Within the construct of well-being, psychologists distinguish eudemonic positive affect and hedonic positive affect, although they are not only nor mutually exclusive approaches. Empirical findings demonstrate a correla - tion between the general positive affect and favorable health outcomes. Recent discoveries also show a biolo - gical pattern, which underlines the correlation. Thanks to describing the conserved transcriptional response to adversity (CTRA) mechanism, a new direction of research is emerging, exploring a relationship between profile of gene expression in immune cells and positive affect.","PeriodicalId":52409,"journal":{"name":"European Journal of Translational and Clinical Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46341066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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