{"title":"Exploring the Role of ChatGPT in Traditional Medicine: A Friend or Foe?","authors":"Amol S. Dhane","doi":"10.18502/tim.v9i1.15083","DOIUrl":"https://doi.org/10.18502/tim.v9i1.15083","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000The Article Abstract is not available. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140254880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Honey has been used since ancient times to treat various diseases such as gynecological diseases. The current study aims to investigate clinical trials related to the therapeutic effects of honey on women's diseases. Databases including Web of Science, Scopus, PubMed, Google scholar, and SID were investigated for clinical studies focusing on honey in gynecological diseases up to 31 June 2022. Eligibility was checked based on selection criteria. Twenty-five clinical trials met the inclusion criteria. Therapeutic properties of honey and its compounds as a systemic and/or local treatment on vulvovaginal candidiasis, cervicitis, dysmenorrhea, premenstrual syndrome, labor pain, episiotomy and cesarean wounds, nipple fissure, breast cancer and intrauterine insemination (IUI), with the mechanisms of action of antibacterial, antifungal, anti-inflammatory, wound healing, analgesic, antioxidant and anticancer activities have been proven. It was also found that phenolic compounds including flavonoids and phenolic acids are the main ones responsible for most of these therapeutic effects of honey. This study supports the healing properties of honey in gynecological diseases at reproductive age. Also, in the current studies, honey proved safe with minor adverse effects. Of course, to achieve definitive conclusions about the effectiveness and safety of honey, it is necessary to conduct more clinical trials with a larger sample size, appropriate intervention duration, and optimal doses in future studies.
蜂蜜自古以来就被用于治疗各种疾病，如妇科疾病。本研究旨在调查与蜂蜜对妇女疾病的治疗效果相关的临床试验。研究人员在 Web of Science、Scopus、PubMed、Google scholar 和 SID 等数据库中搜索了截至 2022 年 6 月 31 日有关蜂蜜治疗妇科疾病的临床研究。根据选择标准对资格进行了检查。有 25 项临床试验符合纳入标准。研究证明，蜂蜜及其化合物具有全身和/或局部治疗外阴阴道念珠菌病、宫颈炎、痛经、经前综合征、分娩疼痛、外阴切开术和剖宫产伤口、乳头皲裂、乳腺癌和宫腔内人工授精（IUI）的功效，其作用机制包括抗菌、抗真菌、抗炎、伤口愈合、镇痛、抗氧化和抗癌。研究还发现，酚类化合物（包括黄酮类化合物和酚酸类化合物）是蜂蜜产生这些治疗效果的主要原因。这项研究证实了蜂蜜对育龄妇女妇科疾病的治疗作用。此外，在目前的研究中，蜂蜜被证明是安全的，不良反应较小。当然，要想对蜂蜜的有效性和安全性得出明确的结论，还需要在今后的研究中进行更多的临床试验，样本量要更大，干预时间要更长，剂量要更适宜。
{"title":"The Role of Honey in Reproductive Age Gynecological Diseases: An Overview of Clinical Trials","authors":"Masoumeh Norouzi Allahleh Korabi, Maedeh Rezghi","doi":"10.18502/tim.v9i1.15089","DOIUrl":"https://doi.org/10.18502/tim.v9i1.15089","url":null,"abstract":"Honey has been used since ancient times to treat various diseases such as gynecological diseases. The current study aims to investigate clinical trials related to the therapeutic effects of honey on women's diseases. Databases including Web of Science, Scopus, PubMed, Google scholar, and SID were investigated for clinical studies focusing on honey in gynecological diseases up to 31 June 2022. Eligibility was checked based on selection criteria. Twenty-five clinical trials met the inclusion criteria. Therapeutic properties of honey and its compounds as a systemic and/or local treatment on vulvovaginal candidiasis, cervicitis, dysmenorrhea, premenstrual syndrome, labor pain, episiotomy and cesarean wounds, nipple fissure, breast cancer and intrauterine insemination (IUI), with the mechanisms of action of antibacterial, antifungal, anti-inflammatory, wound healing, analgesic, antioxidant and anticancer activities have been proven. It was also found that phenolic compounds including flavonoids and phenolic acids are the main ones responsible for most of these therapeutic effects of honey. This study supports the healing properties of honey in gynecological diseases at reproductive age. Also, in the current studies, honey proved safe with minor adverse effects. Of course, to achieve definitive conclusions about the effectiveness and safety of honey, it is necessary to conduct more clinical trials with a larger sample size, appropriate intervention duration, and optimal doses in future studies.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140255211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hajihoseini, Hanieh Tahermohammadi, Babak Daneshfard, Mohammad Saleh Safari, Arian Karimi Rouzbahani
Cerebral palsy (CP) is a condition resulting from injury to the developing brain. Treatment modalities vary based on symptomatology and may range from physiotherapy to pharmacologic intervention and surgical intervention. Despite the current therapeutic strategies, outcomes remain suboptimal. In light of limited data regarding the therapeutic effects of oil-based massages on neonates with CP, this study aimed to investigate the potential neurological benefits of incorporating herbal oils into massage treatments for these infants. In this investigation, we conducted a thorough exploration of the medicinal herbs described in the paralysis section of medical and pharmaceutical sources in Persian medicine. Subsequently, we conducted an extensive literature review on the neurological effects of oils or essential oils derived from these herbs. Our search was conducted up to 2023 using pertinent keywords such as Pimpinella anisum L., anise, aniseed, Foeniculum vulgare Miller, fennel, Carum carvi L., caraway, Piper nigrum L., pepper, Cinnamomum zeylanicum, cinnamon, Nigella sativa L., black seed, Vitis vinifera L., grape seed, Olea europaea L., olive, Rosa x damascena Herrm., and rose flower. We specifically focused on studies related to neuroprotection, neurology, massage, and cerebral palsy, and obtained relevant information from data sources such as PubMed, Scopus, and Google Scholar. Our investigation revealed that massage therapy has an impact on CP and that herbal oils possess neurological properties, such as anticonvulsant and neuroprotective effects, as well as enhancements in behavior, memory, learning, and cerebral function. Based on the advantageous mechanisms of action of herbal oils, we postulate that massage therapy utilizing herbal oils may offer a promising complementary approach in the management of newborns with CP. We recommend further experimental and clinical studies to establish their effectiveness.
{"title":"Massage with Herbal Oils as a Novel Therapeutic Approach for Cerebral Palsy: A Medical Hypothesis","authors":"M. Hajihoseini, Hanieh Tahermohammadi, Babak Daneshfard, Mohammad Saleh Safari, Arian Karimi Rouzbahani","doi":"10.18502/tim.v8i4.14490","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14490","url":null,"abstract":"Cerebral palsy (CP) is a condition resulting from injury to the developing brain. Treatment modalities vary based on symptomatology and may range from physiotherapy to pharmacologic intervention and surgical intervention. Despite the current therapeutic strategies, outcomes remain suboptimal. In light of limited data regarding the therapeutic effects of oil-based massages on neonates with CP, this study aimed to investigate the potential neurological benefits of incorporating herbal oils into massage treatments for these infants. In this investigation, we conducted a thorough exploration of the medicinal herbs described in the paralysis section of medical and pharmaceutical sources in Persian medicine. Subsequently, we conducted an extensive literature review on the neurological effects of oils or essential oils derived from these herbs. Our search was conducted up to 2023 using pertinent keywords such as Pimpinella anisum L., anise, aniseed, Foeniculum vulgare Miller, fennel, Carum carvi L., caraway, Piper nigrum L., pepper, Cinnamomum zeylanicum, cinnamon, Nigella sativa L., black seed, Vitis vinifera L., grape seed, Olea europaea L., olive, Rosa x damascena Herrm., and rose flower. We specifically focused on studies related to neuroprotection, neurology, massage, and cerebral palsy, and obtained relevant information from data sources such as PubMed, Scopus, and Google Scholar. Our investigation revealed that massage therapy has an impact on CP and that herbal oils possess neurological properties, such as anticonvulsant and neuroprotective effects, as well as enhancements in behavior, memory, learning, and cerebral function. Based on the advantageous mechanisms of action of herbal oils, we postulate that massage therapy utilizing herbal oils may offer a promising complementary approach in the management of newborns with CP. We recommend further experimental and clinical studies to establish their effectiveness.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Premalatha Br, Suman Basavaraj, U. Hegde, Jagadeeswari Sudhir, V. Chandavarkar, Swetha Pasupuleti
Energy medicine (EM), is a type of complementary and alternative medicine, which encompasses a range of practices aimed at promoting holistic well-being through the manipulation of energy fields within the body. EM has immense potential in delivering valuable support in a wide range of health conditions. It is imperative for healthcare professionals to be aware of EM, its safety and efficacy in the management of various conditions. Despite its growing popularity, EM remains controversial and encounters several barriers to its recognition and acceptance by the medical fraternity. This paper provides a comprehensive overview of the concept and practice of EM including its history, various types, mechanism of action, applications, driving factors for its practice, current status and future prospects. Putative types of EM modalities are the focus of this paper. Additionally, we examine the challenges to its widespread recognition and acceptance and discuss the importance of further rigorous scientific research to establish its efficacy and safety and bridge the gap between conventional and energy medicine.
{"title":"The Promise and Challenges of Energy Medicine: A Review of the Current Landscape","authors":"Premalatha Br, Suman Basavaraj, U. Hegde, Jagadeeswari Sudhir, V. Chandavarkar, Swetha Pasupuleti","doi":"10.18502/tim.v8i4.14491","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14491","url":null,"abstract":"Energy medicine (EM), is a type of complementary and alternative medicine, which encompasses a range of practices aimed at promoting holistic well-being through the manipulation of energy fields within the body. EM has immense potential in delivering valuable support in a wide range of health conditions. It is imperative for healthcare professionals to be aware of EM, its safety and efficacy in the management of various conditions. Despite its growing popularity, EM remains controversial and encounters several barriers to its recognition and acceptance by the medical fraternity. This paper provides a comprehensive overview of the concept and practice of EM including its history, various types, mechanism of action, applications, driving factors for its practice, current status and future prospects. Putative types of EM modalities are the focus of this paper. Additionally, we examine the challenges to its widespread recognition and acceptance and discuss the importance of further rigorous scientific research to establish its efficacy and safety and bridge the gap between conventional and energy medicine.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"45 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139161999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weeds are considered a great threat to crops. So weed eradication is an important task to increase crop yield. Chemical weed control in various crops decreases their nutritive potential. To overcome this problem to some degree, it is suggested to use these weeds instead of destroying them. Keeping this in view, such losses can be compensated by exploring their medicinal utility and identifying their future medicinal prospects. Chenopodium murale L. (Amaranthaceae) is an annual weed growing throughout the world. This review aims to summarize the reported pharmacology and phytochemistry of C. murale to explore its medicinal utility and identifying their future medicinal prospects. The review was done by literature collection from textbooks and online databases without a time limit. The weed name was confirmed by ‘The Plant List’. C. murale extracts, their isolated active constituents, and nanoparticles have been reported for various pharmacological actions like hepatoprotective, antihypertensive, antidiabetic, antidiarrheal, anticancer, antimicrobial, nematicidal, antioxidant, and cytotoxic. The pharmacological effects of C. murale may be due to the presence of secondary active metabolites such as phenolic acids, flavonols, terpenes and terpenoids, flavonoids and a steroidal glycoside. Reported phytochemistry and pharmacology suggest that C. murale could be an important medicinal agent for leishmaniasis, hypertension, infections and liver diseases. However, further studies are warranted.
{"title":"Chenopodium murale L.: A Weed of Medicinal Importance - A Brief Review","authors":"Tayyeba Rehman, Huma Rao","doi":"10.18502/tim.v8i4.14488","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14488","url":null,"abstract":"Weeds are considered a great threat to crops. So weed eradication is an important task to increase crop yield. Chemical weed control in various crops decreases their nutritive potential. To overcome this problem to some degree, it is suggested to use these weeds instead of destroying them. Keeping this in view, such losses can be compensated by exploring their medicinal utility and identifying their future medicinal prospects. Chenopodium murale L. (Amaranthaceae) is an annual weed growing throughout the world. This review aims to summarize the reported pharmacology and phytochemistry of C. murale to explore its medicinal utility and identifying their future medicinal prospects. The review was done by literature collection from textbooks and online databases without a time limit. The weed name was confirmed by ‘The Plant List’. C. murale extracts, their isolated active constituents, and nanoparticles have been reported for various pharmacological actions like hepatoprotective, antihypertensive, antidiabetic, antidiarrheal, anticancer, antimicrobial, nematicidal, antioxidant, and cytotoxic. The pharmacological effects of C. murale may be due to the presence of secondary active metabolites such as phenolic acids, flavonols, terpenes and terpenoids, flavonoids and a steroidal glycoside. Reported phytochemistry and pharmacology suggest that C. murale could be an important medicinal agent for leishmaniasis, hypertension, infections and liver diseases. However, further studies are warranted.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"121 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Zohourparvaz, Hamidreza Bahrami Taghanaki, Mohammadreza Ghasemian Moghadam, S. Vagharseyyedin
Shoulder pain after laparoscopic cholecystectomy surgery is one of the important complications that can increase patients’ discomfort and their length of stay at the hospital. This study aimed to compare the effects of body acupressure and ear acupressure on shoulder pain in patients undergoing laparoscopic cholecystectomy. Total of 101 patients participated in this randomized controlled clinical trial in 2022. They completed the demographic information form and the Spielberger State-Trait Anxiety Inventory. Then, they were assigned into ear acupressure, body acupressure, and control groups through block randomization. The control group did not receive any intervention. The amount of shoulder pain in patients was recorded in all three groups by using the VAS one (T1), four (T2), and eight (T3) hours after the intervention. The mean shoulder pain score in the ear acupressure group was lower than that in the body acupressure group and the control group in T1 (P<0.001). The median shoulder pain score in the body acupressure group was lower than that in the control group at T2 (P<0.001); the median pain score in the ear acupressure group was significantly lower than that in the other two groups at T2 (P<0.001). The median pain score in the control group was higher than that in the body acupressure and ear acupressure groups at T3 (P<0.001). We observed no statistically significant difference between the body acupressure and ear acupressure groups at T3 (P= 0.12). Statistical analysis showed no difference between the mean anxiety scores of patients in the control, body acupressure, and ear acupressure groups (Z=1.41, P=0.49). Body acupressure and ear acupressure were effective in reducing shoulder pain after laparoscopic cholecystectomy, but ear acupressure was more effective and it showed its analgesic effect faster than body acupressure.
腹腔镜胆囊切除术后肩部疼痛是重要的并发症之一，会增加患者的不适感和住院时间。本研究旨在比较身体穴位按摩和耳部穴位按摩对腹腔镜胆囊切除术患者肩部疼痛的影响。2022年，共有101名患者参与了这项随机对照临床试验。他们填写了人口统计学信息表和斯皮尔伯格状态-特质焦虑量表。然后，通过整群随机法将他们分配到耳部穴位按摩组、身体穴位按摩组和对照组。对照组不接受任何干预。在干预后 1 小时（T1）、4 小时（T2）和 8 小时（T3），使用 VAS 记录三组患者的肩痛程度。在 T1，耳部穴位按摩组的平均肩痛评分低于身体穴位按摩组和对照组（P<0.001）。在 T2 阶段，身体穴位按摩组的肩痛中位数低于对照组（P<0.001）；在 T2 阶段，耳部穴位按摩组的肩痛中位数明显低于其他两组（P<0.001）。在 T3 阶段，对照组的疼痛中位数高于身体穴位按摩组和耳部穴位按摩组（P<0.001）。我们观察到，在 T3 阶段，身体穴位按摩组和耳部穴位按摩组之间的差异无统计学意义（P= 0.12）。统计分析显示，对照组、身体穴位按摩组和耳部穴位按摩组患者的平均焦虑评分没有差异（Z=1.41，P=0.49）。身体穴位按摩和耳部穴位按摩在减轻腹腔镜胆囊切除术后肩部疼痛方面效果显著，但耳部穴位按摩比身体穴位按摩更有效，且镇痛效果显现得更快。
{"title":"Comparison of the Effects of Body Acupressure and Ear Acupressure on Shoulder Pain in Iranian Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial","authors":"M. Zohourparvaz, Hamidreza Bahrami Taghanaki, Mohammadreza Ghasemian Moghadam, S. Vagharseyyedin","doi":"10.18502/tim.v8i4.14485","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14485","url":null,"abstract":"Shoulder pain after laparoscopic cholecystectomy surgery is one of the important complications that can increase patients’ discomfort and their length of stay at the hospital. This study aimed to compare the effects of body acupressure and ear acupressure on shoulder pain in patients undergoing laparoscopic cholecystectomy. Total of 101 patients participated in this randomized controlled clinical trial in 2022. They completed the demographic information form and the Spielberger State-Trait Anxiety Inventory. Then, they were assigned into ear acupressure, body acupressure, and control groups through block randomization. The control group did not receive any intervention. The amount of shoulder pain in patients was recorded in all three groups by using the VAS one (T1), four (T2), and eight (T3) hours after the intervention. The mean shoulder pain score in the ear acupressure group was lower than that in the body acupressure group and the control group in T1 (P<0.001). The median shoulder pain score in the body acupressure group was lower than that in the control group at T2 (P<0.001); the median pain score in the ear acupressure group was significantly lower than that in the other two groups at T2 (P<0.001). The median pain score in the control group was higher than that in the body acupressure and ear acupressure groups at T3 (P<0.001). We observed no statistically significant difference between the body acupressure and ear acupressure groups at T3 (P= 0.12). Statistical analysis showed no difference between the mean anxiety scores of patients in the control, body acupressure, and ear acupressure groups (Z=1.41, P=0.49). Body acupressure and ear acupressure were effective in reducing shoulder pain after laparoscopic cholecystectomy, but ear acupressure was more effective and it showed its analgesic effect faster than body acupressure.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"25 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Babatunde E. Ajayi, Yetunde Adesola Odueke, Favour Marian Ibrahim, Macdonald Ighodaro, J. T. Bamgbose
Globally, herbal contraceptives remain a viable option for women in rural settlements with unmet contraceptive needs. Pharmacological reports of the male contraceptive potential of Xylopia aethiopica (Dunal) A.Rich. fruit exist in literature, but there is a paucity of information on its female contraceptive potential. This study evaluated the efficacy of aqueous extract of X. aethiopica fruit (AEXAF) as a reversible contraceptive remedy in female Sprague Dawley rats against a combined oral contraceptive drug containing ethinyl estradiol and levonorgestrel (COC-EEL). AEXAF was obtained by boiling air-dried pulverized fruit samples in water for 15 minutes. Phytochemical screening of AEXAF was carried out. Mature female rats (30) were assigned into six groups, five per group, with ±20 g weight difference within each group. Group A received water; Groups B, C, D and E received 50, 100, 200, and 300 mg/kg/B.W. doses of AEXAF, respectively; Group F received 3.6 µg/kg/B.W. dose of COC-EEL. COC-EEL and AEXAF were administered orally, once daily, for 21 days. After 14 days of treatment, mature male rats were introduced to the females, two males per group, for 7 days. Litter size was recorded after delivery. Rats that did not produce pups were immediately re-introduced to male rats for 7 days and sacrificed after another 7 days; the number of fetuses in their uteri was determined. The data obtained was analyzed using Unpaired-t test. Phytochemical screening of AEXAF revealed the presence of alkaloids, flavonoids and saponins. High contraceptive efficacy (80%) with 100% reversibility was observed at 50 and 300 mg/kg/B.W. doses of AEXAF; whereas COC-EEL showed 60% efficacy and 100% reversibility. The 100 and 200 mg/kg/B.W. doses of AEXAF did not protect against conception. X. aethiopica possesses contraceptive potential worthy of further scientific consideration.
{"title":"Contraceptive Efficacy of Aqueous Extract of Xylopia aethiopica (Dunal) A.Rich. Fruit in Female Sprague Dawley Rats","authors":"Babatunde E. Ajayi, Yetunde Adesola Odueke, Favour Marian Ibrahim, Macdonald Ighodaro, J. T. Bamgbose","doi":"10.18502/tim.v8i4.14484","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14484","url":null,"abstract":"Globally, herbal contraceptives remain a viable option for women in rural settlements with unmet contraceptive needs. Pharmacological reports of the male contraceptive potential of Xylopia aethiopica (Dunal) A.Rich. fruit exist in literature, but there is a paucity of information on its female contraceptive potential. This study evaluated the efficacy of aqueous extract of X. aethiopica fruit (AEXAF) as a reversible contraceptive remedy in female Sprague Dawley rats against a combined oral contraceptive drug containing ethinyl estradiol and levonorgestrel (COC-EEL). AEXAF was obtained by boiling air-dried pulverized fruit samples in water for 15 minutes. Phytochemical screening of AEXAF was carried out. Mature female rats (30) were assigned into six groups, five per group, with ±20 g weight difference within each group. Group A received water; Groups B, C, D and E received 50, 100, 200, and 300 mg/kg/B.W. doses of AEXAF, respectively; Group F received 3.6 µg/kg/B.W. dose of COC-EEL. COC-EEL and AEXAF were administered orally, once daily, for 21 days. After 14 days of treatment, mature male rats were introduced to the females, two males per group, for 7 days. Litter size was recorded after delivery. Rats that did not produce pups were immediately re-introduced to male rats for 7 days and sacrificed after another 7 days; the number of fetuses in their uteri was determined. The data obtained was analyzed using Unpaired-t test. Phytochemical screening of AEXAF revealed the presence of alkaloids, flavonoids and saponins. High contraceptive efficacy (80%) with 100% reversibility was observed at 50 and 300 mg/kg/B.W. doses of AEXAF; whereas COC-EEL showed 60% efficacy and 100% reversibility. The 100 and 200 mg/kg/B.W. doses of AEXAF did not protect against conception. X. aethiopica possesses contraceptive potential worthy of further scientific consideration.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"100 S103","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ketmanee Jongjiamdee, Thanaphak Chaowpeerapong, Pichitpol Kerdsomnuek, Suksalin Booranasubkajorn, B. Vanadurongwan, Weerawat Limroongreungrat, P. Akarasereenont, A. Asavamongkolkul
This study was conducted to investigate the three-dimensional (3D) joint angles and muscle activities of the lower extremities when performing the Ruesi Dat Ton: a form of traditional Thai medicine involving stretching and strengthening postures. Thirty healthy volunteers were recruited in order to let them perform five Ruesi Dat Ton postures, namely Tha Kae Khao Kae Kha, Tha Kae Lom Nai Ook Nai Eo, Tha Kae Klon Pattakhat, Tha Kae Siat Ook, and Tha Kae Lom Pat-Khat Kae Lom Nai Eo, by a random sequence of postures. The 3D joint angles and muscle activities during the performance of the Ruesi Dat Ton were analyzed at the 3D-motion analysis laboratory. Descriptive statistics were used for the analysis. All the Ruesi Dat Ton postures were in the normal range of motion of the back, hips, knees, and ankles. However, when compared to the joint angle values from the 3D motion analysis, a higher joint angle was found in the hip rotation of Tha Kae Khao Kae Kha (27.99±16.72 degrees), Tha Kae Lom Nai Ook Nai Eo (25.99±14.76 degrees), and Tha Kae Klon Pattakhat (20.99±12.59 degrees), knee flexion of Tha Kae Siat Ook (140.05±8.98 degrees), and trunk flexion of Tha Kae Lom Pat-Khat Kae Lom Nai Eo (52.10±14.83 degrees). All the postures produced more than 1% maximum voluntary isometric contraction of the muscle (MVIC). The muscle activities of Tha Kae Siat Ook were the most contracted, whereas Tha Kae Lom Pat-Khat Kae Lom Nai Eo were the least. Moreover, the study found that the rectus femoris muscle was the most active muscle in all postures. In conclusion, this research can help to select the most appropriate Ruesi Dat Ton posture to maximize the benefits for practitioners and to ensure safety while performing the postures.
本研究旨在调查在做 Ruesi Dat Ton（一种涉及伸展和强化姿势的泰国传统医学）时下肢的三维（3D）关节角度和肌肉活动。研究人员招募了 30 名健康志愿者，让他们以随机顺序做五种 Ruesi Dat Ton 姿势，即 Tha Kae Khao Kae Kha、Tha Kae Lom Nai Ook Nai Eo、Tha Kae Klon Pattakhat、Tha Kae Siat Ook 和 Tha Kae Lom Pat-Khat Kae Lom Nai Eo。在三维运动分析实验室中对 Ruesi Dat Ton 表演过程中的三维关节角度和肌肉活动进行了分析。分析采用了描述性统计方法。所有的 "如意达通 "姿势都在背部、臀部、膝盖和脚踝的正常运动范围内。然而，与三维运动分析得出的关节角度值相比，Tha Kae Khao Kae Kha（27.99±16.72 度）、Tha Kae Lom Nai Ook Nai Eo（25.99±14.76度）和Tha Kae Klon Pattakhat（20.99±12.59度），Tha Kae Siat Ook的膝关节屈曲（140.05±8.98度）和Tha Kae Lom Pat-Khat Kae Lom Nai Eo的躯干屈曲（52.10±14.83度）。所有姿势都能产生超过 1%的肌肉最大自主等长收缩（MVIC）。Tha Kae Siat Ook 的肌肉活动收缩最大，而 Tha Kae Lom Pat-Khat Kae Lom Nai Eo 的肌肉活动收缩最小。此外，研究还发现股直肌是所有姿势中最活跃的肌肉。总之，这项研究有助于选择最合适的 Ruesi Dat Ton 体位，为练习者带来最大益处，并确保体位练习时的安全。
{"title":"Three-Dimensional Kinematic Analysis of the Lower Extremity in Ruesi Dat Ton Postures Performed by Healthy Volunteers","authors":"Ketmanee Jongjiamdee, Thanaphak Chaowpeerapong, Pichitpol Kerdsomnuek, Suksalin Booranasubkajorn, B. Vanadurongwan, Weerawat Limroongreungrat, P. Akarasereenont, A. Asavamongkolkul","doi":"10.18502/tim.v8i4.14487","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14487","url":null,"abstract":"This study was conducted to investigate the three-dimensional (3D) joint angles and muscle activities of the lower extremities when performing the Ruesi Dat Ton: a form of traditional Thai medicine involving stretching and strengthening postures. Thirty healthy volunteers were recruited in order to let them perform five Ruesi Dat Ton postures, namely Tha Kae Khao Kae Kha, Tha Kae Lom Nai Ook Nai Eo, Tha Kae Klon Pattakhat, Tha Kae Siat Ook, and Tha Kae Lom Pat-Khat Kae Lom Nai Eo, by a random sequence of postures. The 3D joint angles and muscle activities during the performance of the Ruesi Dat Ton were analyzed at the 3D-motion analysis laboratory. Descriptive statistics were used for the analysis. All the Ruesi Dat Ton postures were in the normal range of motion of the back, hips, knees, and ankles. However, when compared to the joint angle values from the 3D motion analysis, a higher joint angle was found in the hip rotation of Tha Kae Khao Kae Kha (27.99±16.72 degrees), Tha Kae Lom Nai Ook Nai Eo (25.99±14.76 degrees), and Tha Kae Klon Pattakhat (20.99±12.59 degrees), knee flexion of Tha Kae Siat Ook (140.05±8.98 degrees), and trunk flexion of Tha Kae Lom Pat-Khat Kae Lom Nai Eo (52.10±14.83 degrees). All the postures produced more than 1% maximum voluntary isometric contraction of the muscle (MVIC). The muscle activities of Tha Kae Siat Ook were the most contracted, whereas Tha Kae Lom Pat-Khat Kae Lom Nai Eo were the least. Moreover, the study found that the rectus femoris muscle was the most active muscle in all postures. In conclusion, this research can help to select the most appropriate Ruesi Dat Ton posture to maximize the benefits for practitioners and to ensure safety while performing the postures.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"83 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Lamardi, Mohammad Reza Shams Ardekani, Katayoon Mireskandari, Mohammad Sharifzadeh, Maryam Yachchali, S. Sadrai
In Traditional Persian Medicine (TPM) saffron is used as an accompaniment agent “Mobadreq” in polyherbal formulations. According to TPM texts, “Mobadreq” is a substance (or drug) which facilitates access of drugs or food to the whole body or specific organs. This study investigated the effect of oral co-administration of Crocus sativus L. (saffron) on the absorption and some pharmacokinetic parameters of acetaminophen in rats. Two groups of rats (n=6) were treated by 1: acetaminophen 10 mg/kg along with Crocus sativus 4 mg/kg (test group) and 2: 10 mg/kg acetaminophen (control). The plasma concentrations of acetaminophen after oral administration (at 0, 5, 10, 15, 20, 40, 60, 90, and 120 min) were monitored by an HPLC-UV method. Results indicated that the plasma concentration of acetaminophen in the test group was reached to the maximum concentration (Cmax) faster than control group. As a result, at 5 to 40 minutes after drug gavage, the concentration of acetaminophen in both groups was significantly different. It was also found that co-administration of acetaminophen and saffron significantly increased acetaminophen’s area under concentration curve (AUC0-60) in comparison to the acetaminophen alone (p<0.025). These results suggest that saffron could increase the absorption rate of acetaminophen. Consequently, saffron can be considered and introduced as an enhancer of absorption rate and efficacy of acetaminophen and other drugs at least by oral route although the drug interactions with this herb should be considered.
{"title":"Effect of Saffron (Crocus sativus L.), as a Bioenhancer, on Pharmacokinetic of Acetaminophen: An Animal Study","authors":"S. Lamardi, Mohammad Reza Shams Ardekani, Katayoon Mireskandari, Mohammad Sharifzadeh, Maryam Yachchali, S. Sadrai","doi":"10.18502/tim.v8i4.14482","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14482","url":null,"abstract":"In Traditional Persian Medicine (TPM) saffron is used as an accompaniment agent “Mobadreq” in polyherbal formulations. According to TPM texts, “Mobadreq” is a substance (or drug) which facilitates access of drugs or food to the whole body or specific organs. This study investigated the effect of oral co-administration of Crocus sativus L. (saffron) on the absorption and some pharmacokinetic parameters of acetaminophen in rats. Two groups of rats (n=6) were treated by 1: acetaminophen 10 mg/kg along with Crocus sativus 4 mg/kg (test group) and 2: 10 mg/kg acetaminophen (control). The plasma concentrations of acetaminophen after oral administration (at 0, 5, 10, 15, 20, 40, 60, 90, and 120 min) were monitored by an HPLC-UV method. Results indicated that the plasma concentration of acetaminophen in the test group was reached to the maximum concentration (Cmax) faster than control group. As a result, at 5 to 40 minutes after drug gavage, the concentration of acetaminophen in both groups was significantly different. It was also found that co-administration of acetaminophen and saffron significantly increased acetaminophen’s area under concentration curve (AUC0-60) in comparison to the acetaminophen alone (p<0.025). These results suggest that saffron could increase the absorption rate of acetaminophen. Consequently, saffron can be considered and introduced as an enhancer of absorption rate and efficacy of acetaminophen and other drugs at least by oral route although the drug interactions with this herb should be considered.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dysmenorrhea has a negative impact on women's daily activities and quality of life. The purpose of this study was to investigate the effect of topically applied chamomile oil along with dry cupping on dysmenorrhea. A total of 12 patients with dysmenorrhea were included in this quasi-experimental study and treated for three consecutive cycle periods. One mL of chamomile oil was gently massaged on the skin of the suprapubic area for 10 minutes once every night. After the massage, dry cupping was done. During the study, patients were visited on the third day of menstruation for three consecutive cycles, and mean pain was evaluated and recorded based on the visual analog scale (VAS). The mean ± SD of pain intensity in three cycles before the study was 7.5 ± 0.43 and in three cycles after the interventions was 1.44 ± 0.33 (P= 0.002). Indeed, the pain score was decreased as 86.72±1.12% due to the interventions. All the patients discontinued using the analgesic during the study. Topical application of chamomile oil and dry cupping significantly reduced the severity of pain during menstruation and it could be considered as a low-cost modality without side effects for dysmenorrhea. Further studies with larger sample size and longer follow-up are recommended.
{"title":"Topical Application of Chamomile Oil in Combination with Dry Cupping for Dysmenorrhea: A Quasi-Experimental Study","authors":"Majid Dadmehr, Fataneh Hashem-Dabaghian, Elham Akhtari","doi":"10.18502/tim.v8i4.14480","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14480","url":null,"abstract":"Dysmenorrhea has a negative impact on women's daily activities and quality of life. The purpose of this study was to investigate the effect of topically applied chamomile oil along with dry cupping on dysmenorrhea. A total of 12 patients with dysmenorrhea were included in this quasi-experimental study and treated for three consecutive cycle periods. One mL of chamomile oil was gently massaged on the skin of the suprapubic area for 10 minutes once every night. After the massage, dry cupping was done. During the study, patients were visited on the third day of menstruation for three consecutive cycles, and mean pain was evaluated and recorded based on the visual analog scale (VAS). The mean ± SD of pain intensity in three cycles before the study was 7.5 ± 0.43 and in three cycles after the interventions was 1.44 ± 0.33 (P= 0.002). Indeed, the pain score was decreased as 86.72±1.12% due to the interventions. All the patients discontinued using the analgesic during the study. Topical application of chamomile oil and dry cupping significantly reduced the severity of pain during menstruation and it could be considered as a low-cost modality without side effects for dysmenorrhea. Further studies with larger sample size and longer follow-up are recommended.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"16 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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