{"title":"WHO World Traditional Medicine Summit 2023 in Gujarat: A Turning Point for Traditional Medicine Worldwide","authors":"Arman Zargaran","doi":"10.18502/tim.v8i4.14479","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14479","url":null,"abstract":"The Article Abstract is not available.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oxidative stress may play a pivotal role in the pathogenesis of depression. Furthermore, antioxidants are also believed to have antidepressant properties. Previous studies have reported the antioxidant effects of Satureja khuzestanica Jamzad. Therefore, this study examined the antidepressant potential of Satureja khuzestanica essential oil (SKEO) in male mice based on a forced swim test (FST) and tail suspension test (TST). The GC-MS was used to evaluate the phytochemistry of SKEO. In behavioral studies, 72 male mice were allocated to twelve groups of six and intraperitoneally received the vehicle (10 mL/kg), fluoxetine (20 mg/kg), imipramine (30 mg/kg), or SKEO (25, 50, and 100 mg/kg). Immobility time in TST and immobility, swimming, and climbing times in FST were measured. In the open-field test (OFT), the number of crossings and rearings was recorded. According to GC-MS results, carvacrol, γ-terpinene, cymene, and 2-pinene were the most abundant compounds in SKEO. In FST and TST, all doses of SKEO (except for 25 mg/kg in FST), fluoxetine, and imipramine reduced the immobility time compared to the control group. Moreover, 50 and 100 mg/kg doses of SKEO and fluoxetine increased the swimming time without significantly changing the climbing time. However, imipramine increased the climbing time without significantly changing the swimming time. None of SKEO doses caused a significant change in the number of crossings or rearings in OFT. According to our findings, the antidepressant-like effects of SKEO are similar to those of fluoxetine. While the compounds in SKEO seem to induce their effects through the serotonergic mechanism, further studies are warranted to clarify their exact mechanism of action.
{"title":"Phytochemical Properties and Antidepressant Potential of Satureja khuzestanica Jamzad Essential Oil in Mouse Models of Depression","authors":"Seyed Sepehr Seyedi, Saeid Abbasi-Maleki, Ghader Najafi","doi":"10.18502/tim.v8i4.14481","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14481","url":null,"abstract":"Oxidative stress may play a pivotal role in the pathogenesis of depression. Furthermore, antioxidants are also believed to have antidepressant properties. Previous studies have reported the antioxidant effects of Satureja khuzestanica Jamzad. Therefore, this study examined the antidepressant potential of Satureja khuzestanica essential oil (SKEO) in male mice based on a forced swim test (FST) and tail suspension test (TST). The GC-MS was used to evaluate the phytochemistry of SKEO. In behavioral studies, 72 male mice were allocated to twelve groups of six and intraperitoneally received the vehicle (10 mL/kg), fluoxetine (20 mg/kg), imipramine (30 mg/kg), or SKEO (25, 50, and 100 mg/kg). Immobility time in TST and immobility, swimming, and climbing times in FST were measured. In the open-field test (OFT), the number of crossings and rearings was recorded. According to GC-MS results, carvacrol, γ-terpinene, cymene, and 2-pinene were the most abundant compounds in SKEO. In FST and TST, all doses of SKEO (except for 25 mg/kg in FST), fluoxetine, and imipramine reduced the immobility time compared to the control group. Moreover, 50 and 100 mg/kg doses of SKEO and fluoxetine increased the swimming time without significantly changing the climbing time. However, imipramine increased the climbing time without significantly changing the swimming time. None of SKEO doses caused a significant change in the number of crossings or rearings in OFT. According to our findings, the antidepressant-like effects of SKEO are similar to those of fluoxetine. While the compounds in SKEO seem to induce their effects through the serotonergic mechanism, further studies are warranted to clarify their exact mechanism of action.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"54 159","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Among cosmetic surgeries, nose surgery is more anxiety-provoking than other surgeries. By causing mental stress, surgery leads to the disruption of vital signs. By releasing endorphins in the brain, aromatherapy leads to a feeling of well-being. This study was conducted to determine the effect of lemon scent on patients' anxiety before rhinoplasty surgery. This clinical trial was conducted on 30 candidates for rhinoplasty surgery at Kashani Hospital of Isfahan in 2022. Patients were divided into two intervention and control groups (15 people in each group) by random allocation method. The research tool was Spielberger's standard questionnaire, completed immediately before and 20 to 30 minutes after the intervention by two groups. Data were analyzed using SPSS 16 software, descriptive statistics and independent t-test, paired t-test and MANCOVA test at a significance level of less than 0.05. Two groups were homogeneous in terms of demographic variables. The mean latent anxiety score in the intervention group before the intervention was 42.26±10.06, and after the intervention was 35.8±8.86, which had a statistically significant difference (p= 0.002). The mean overt anxiety score in the intervention group was 42.60±8.66 before the intervention, and 31.86±5.81 after the intervention which was statistically significant (p< 0.001). The results showed a statistically significant difference between the intervention and control groups in the mean of hidden (p= 0.029) and overt anxiety (p= 0.001). Using lemon scent as an effective, non-invasive and cost-effective non-medicinal intervention reduces the preoperative anxiety of rhinoplasty candidates, so, it is possible to benefit from the scent of lemon to reduce patients' anxiety.
{"title":"Effect of Lemon Scent on Anxiety in Patients before Rhinoplasty Surgery: A Randomized Controlled Trial","authors":"Maryam Amirshakari, M. J. Tarahi, Ahmed Gadami","doi":"10.18502/tim.v8i4.14483","DOIUrl":"https://doi.org/10.18502/tim.v8i4.14483","url":null,"abstract":"Among cosmetic surgeries, nose surgery is more anxiety-provoking than other surgeries. By causing mental stress, surgery leads to the disruption of vital signs. By releasing endorphins in the brain, aromatherapy leads to a feeling of well-being. This study was conducted to determine the effect of lemon scent on patients' anxiety before rhinoplasty surgery. This clinical trial was conducted on 30 candidates for rhinoplasty surgery at Kashani Hospital of Isfahan in 2022. Patients were divided into two intervention and control groups (15 people in each group) by random allocation method. The research tool was Spielberger's standard questionnaire, completed immediately before and 20 to 30 minutes after the intervention by two groups. Data were analyzed using SPSS 16 software, descriptive statistics and independent t-test, paired t-test and MANCOVA test at a significance level of less than 0.05. Two groups were homogeneous in terms of demographic variables. The mean latent anxiety score in the intervention group before the intervention was 42.26±10.06, and after the intervention was 35.8±8.86, which had a statistically significant difference (p= 0.002). The mean overt anxiety score in the intervention group was 42.60±8.66 before the intervention, and 31.86±5.81 after the intervention which was statistically significant (p< 0.001). The results showed a statistically significant difference between the intervention and control groups in the mean of hidden (p= 0.029) and overt anxiety (p= 0.001). Using lemon scent as an effective, non-invasive and cost-effective non-medicinal intervention reduces the preoperative anxiety of rhinoplasty candidates, so, it is possible to benefit from the scent of lemon to reduce patients' anxiety.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"30 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Sheibani, Maryam Shayan, Majid Jafari-Sabet, Ali Mohammad Sharifi
Phytomedicines, also known as plant-derived drugs, possess preventive and therapeutic effects. Herbal medicines exert a wide range of biological and medicinal properties along with beneficial advantages, including fewer side-effects and lower costs compared to their chemical counterparts. Herbal derivates form basis of many available chemical medicines such as Atropine, Hyoscyamine, Quinine, Colchicine, Digoxin, Codeine, and Morphine. Asian and African populations consume herbal medicine for therapeutic purposes by 60-80%. In the United States, 25% of pharmaceutical medications have at least one herbal-derived ingredient in their structure. Regenerative Medicine (RM) employs stem cells and tissue engineering technology to restore injured cells and repair tissue damage. Stem cells are undifferentiated cells, which can be differentiated into numerous cells. Mesenchymal Stem Cells (MSCs) as multipotent stem cells are the most frequently used stem cells in RM, which can be differentiated into several cell types such as adipocytes, osteocytes, and chondrocytes. Bone disorders and cartilage injuries are not responsive to currently available therapies; thus, researchers have focused on herbal-based stem cell therapies. The present study aimed to review the mechanism underlying the therapeutic application of phytomedicines in the RM and their efficacy in osteogenesis and chondrogenesis.
{"title":"Applications of Phytomedicines in Chondrocytes and Osteocytes Regeneration Therapy: Pre-Clinical and Clinical Studies","authors":"Mohammad Sheibani, Maryam Shayan, Majid Jafari-Sabet, Ali Mohammad Sharifi","doi":"10.18502/tim.v8i3.13716","DOIUrl":"https://doi.org/10.18502/tim.v8i3.13716","url":null,"abstract":"Phytomedicines, also known as plant-derived drugs, possess preventive and therapeutic effects. Herbal medicines exert a wide range of biological and medicinal properties along with beneficial advantages, including fewer side-effects and lower costs compared to their chemical counterparts. Herbal derivates form basis of many available chemical medicines such as Atropine, Hyoscyamine, Quinine, Colchicine, Digoxin, Codeine, and Morphine. Asian and African populations consume herbal medicine for therapeutic purposes by 60-80%. In the United States, 25% of pharmaceutical medications have at least one herbal-derived ingredient in their structure. Regenerative Medicine (RM) employs stem cells and tissue engineering technology to restore injured cells and repair tissue damage. Stem cells are undifferentiated cells, which can be differentiated into numerous cells. Mesenchymal Stem Cells (MSCs) as multipotent stem cells are the most frequently used stem cells in RM, which can be differentiated into several cell types such as adipocytes, osteocytes, and chondrocytes. Bone disorders and cartilage injuries are not responsive to currently available therapies; thus, researchers have focused on herbal-based stem cell therapies. The present study aimed to review the mechanism underlying the therapeutic application of phytomedicines in the RM and their efficacy in osteogenesis and chondrogenesis.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"30 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135245871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sesame oil (SO) or so-called Tahini has been traditionally used for management of various conditions including burns and wounds and relief of pain, fever, and inflammation n Persian Medicine. It poses anti-inflammatory, antioxidant, and anti-carcinogenic activities; then it could be used in various inflammatory conditions. A triple-blind randomized placebo-controlled clinical trial was carried out to examine the efficacy of a Persian natural topical medicine based on sesame oil in outpatients suffering mild and moderate coronavirus disease-19 (COVID-19). The participants were 101 COVID-19 patients who met the inclusion criteria. The participants were allocated randomly to treatment (n = 51) group who received topical Sesame oil formulation five times daily on the chest and back skin for 1 week or the placebo (n = 50) group. The symptoms were examined at admittance and over a follow-up course and the results were compared in the two groups after 3 and 7 days. After three days, fever (7.84 vs. 20.41%, P=0.05), chills (3.92 vs. 16.33%, P=0.03), cough (severe 0 vs. 8.6, intermediate 50.98 vs. 65.31%, P=0.007) and headache (mild 7.84 vs. 30.61, moderate 5.88 vs. 0, P=0.004) had a significant lower prevalence in the treatment group. However, after 7 days, all symptoms had insignificant difference between two groups (P>0.05). No significant adverse reaction reported in both groups. As the results indicated, topical formulation consisting of sesame oil and cow butter, rubbing on the chest and back of the mild-to-moderate COVID-19 patients five times daily could significantly improve cough, fever, chills and headache, in 3 days. But it could not be effective on final outcome of the patients. More works covering a larger sample size are needed.
{"title":"Evaluation of a Persian Natural Topical Medicine Based on Sesame Oil on Mild-to-Moderate Outpatient Coronavirus Disease-19 Patients: A Randomized Triple-Blind Placebo-Controlled Clinical Trial","authors":"Reza Ahmadi, Hossein Mohammadzadeh-Moghadam, Reza Esmaeili, Abdoljavad Khajavi, Maryam Ghahramany, Davoud Salarbashi, Mahdieh Bahramizadeh, Sepideh Elyasi","doi":"10.18502/tim.v8i3.13710","DOIUrl":"https://doi.org/10.18502/tim.v8i3.13710","url":null,"abstract":"Sesame oil (SO) or so-called Tahini has been traditionally used for management of various conditions including burns and wounds and relief of pain, fever, and inflammation n Persian Medicine. It poses anti-inflammatory, antioxidant, and anti-carcinogenic activities; then it could be used in various inflammatory conditions. A triple-blind randomized placebo-controlled clinical trial was carried out to examine the efficacy of a Persian natural topical medicine based on sesame oil in outpatients suffering mild and moderate coronavirus disease-19 (COVID-19). The participants were 101 COVID-19 patients who met the inclusion criteria. The participants were allocated randomly to treatment (n = 51) group who received topical Sesame oil formulation five times daily on the chest and back skin for 1 week or the placebo (n = 50) group. The symptoms were examined at admittance and over a follow-up course and the results were compared in the two groups after 3 and 7 days. After three days, fever (7.84 vs. 20.41%, P=0.05), chills (3.92 vs. 16.33%, P=0.03), cough (severe 0 vs. 8.6, intermediate 50.98 vs. 65.31%, P=0.007) and headache (mild 7.84 vs. 30.61, moderate 5.88 vs. 0, P=0.004) had a significant lower prevalence in the treatment group. However, after 7 days, all symptoms had insignificant difference between two groups (P>0.05). No significant adverse reaction reported in both groups. As the results indicated, topical formulation consisting of sesame oil and cow butter, rubbing on the chest and back of the mild-to-moderate COVID-19 patients five times daily could significantly improve cough, fever, chills and headache, in 3 days. But it could not be effective on final outcome of the patients. More works covering a larger sample size are needed.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Pourshahidi, Houman Ebrahimi, Zahra Zeraat, Mohammad Mahdi Parvizi, Hajar Zolfaghari
Oral lichen planus and lichenoid reactions are autoimmune chronic inflammatory diseases. Since the inflammatory system is the main pathological process in these lesions, some etiological roles for inflammatory cytokines and personal temperaments (Mizaj) are proposed. In this preliminary study, establishing such an association between personal temperaments with oral lichen planus and lichenoid reactions would develop new horizons for better preventive programming to prevent or control the disease course in affected patients. This case-control study was carried out among 384 patients referred to the oral medicine department of dental school, Tehran University of Medical Sciences, from 2000 to 2017. They were categorized into three groups as follows: oral lichen planus (128), oral lichenoid reactions (128), and healthy control group (128). The temperament was assessed by Mojahedi et al. validated questionnaire, and the results were compared across the groups. Warm temperament was significantly higher in the lichen planus group (P=0.0001). The dry temperament was higher in oral lichen planus and lichenoid groups. In these groups, the intermediate group had the least rate, but in the control group, the moist temperament was less common. No statistically significant difference existed between groups in this era (P=0.210). However, among mixed temperaments, the warm and moist temperament was the same across the groups (P=0.195); the warm and dry temperament was significantly more common in cases with oral lichen planus (P < 0.001); and the cold and dry temperament (P=0.017) and cold and moist temperament (P <0.001) were significantly more common in the control group. The only difference between the two groups of control and lichenoid reactions was cold and dry temperament (P=0.008). This study revealed that warm temperament is related to oral lichen planus. Reestablishing this matter in future studies would help develop some evidence-based preventive strategies to reduce the burden of oral lichen planus.
{"title":"Relationship between Personal Temperaments Based on the Traditional Medicine Knowledge and Lichen Planus and Lichenoid Reaction Disorders","authors":"Sara Pourshahidi, Houman Ebrahimi, Zahra Zeraat, Mohammad Mahdi Parvizi, Hajar Zolfaghari","doi":"10.18502/tim.v8i3.13709","DOIUrl":"https://doi.org/10.18502/tim.v8i3.13709","url":null,"abstract":"Oral lichen planus and lichenoid reactions are autoimmune chronic inflammatory diseases. Since the inflammatory system is the main pathological process in these lesions, some etiological roles for inflammatory cytokines and personal temperaments (Mizaj) are proposed. In this preliminary study, establishing such an association between personal temperaments with oral lichen planus and lichenoid reactions would develop new horizons for better preventive programming to prevent or control the disease course in affected patients. This case-control study was carried out among 384 patients referred to the oral medicine department of dental school, Tehran University of Medical Sciences, from 2000 to 2017. They were categorized into three groups as follows: oral lichen planus (128), oral lichenoid reactions (128), and healthy control group (128). The temperament was assessed by Mojahedi et al. validated questionnaire, and the results were compared across the groups. Warm temperament was significantly higher in the lichen planus group (P=0.0001). The dry temperament was higher in oral lichen planus and lichenoid groups. In these groups, the intermediate group had the least rate, but in the control group, the moist temperament was less common. No statistically significant difference existed between groups in this era (P=0.210). However, among mixed temperaments, the warm and moist temperament was the same across the groups (P=0.195); the warm and dry temperament was significantly more common in cases with oral lichen planus (P < 0.001); and the cold and dry temperament (P=0.017) and cold and moist temperament (P <0.001) were significantly more common in the control group. The only difference between the two groups of control and lichenoid reactions was cold and dry temperament (P=0.008). This study revealed that warm temperament is related to oral lichen planus. Reestablishing this matter in future studies would help develop some evidence-based preventive strategies to reduce the burden of oral lichen planus.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Because of the anti-inflammatory properties of thymoquinone (TQ), as the main bioactive substance of Nigella sativa L., this systematic review aimed at assessing the therapeutic effects of N. sativa and its main bioactive substance in the management of patients with osteoarthritis (OA) based on the in vivo, in vitro, and in clinical studies. The methodology was adjusted based on the Cochrane Handbook recommendations. All published articles focusing on N. sativa as a therapeutic agent for the treatment of OA or its animal model were searched up to 20 April 2022 in PubMed, Medline, Web of Sciences, and Scopus databases. The search process was carried out using the following keywords: "Nigella sativa", "Black seed', "Black cumin", and "Thymoquinone" in combination with "Osteoarthritis". Finally, 14 articles remained, including five intervention clinical trial, two human studies, and seven animal studies. Four of five intervention studies showed that N. sativa administration led to relief in pain intensity. In the other clinical trial, no difference was reported between the N. sativa and control groups in terms of pain relief among OA patients. Studies demonstrated the anti-inflammatory and chondroprotective effects of TQ as the main bioactive substance of N. sativa. The evidence confirmed the anti-inflammatory and chondroprotective effects of N. sativa in the management of OA patients. Considering the lack of significant adverse effects such as allergic reaction to N. sativa in the aforementioned studies, this substance can be recommended as a safe adjuvant treatment to relieve OA pain, compared to nonsteroidal anti-inflammatory drugs and other analgesics.
由于百里香醌(TQ)是黑草(Nigella sativa L.)的主要生物活性物质，具有抗炎作用，本系统综述旨在通过体内、体外和临床研究来评价黑草(Nigella sativa L.)及其主要生物活性物质对骨关节炎(OA)的治疗效果。方法根据Cochrane手册的建议进行了调整。截至2022年4月20日，我们在PubMed、Medline、Web of Sciences和Scopus数据库中检索了所有关于N. sativa作为OA治疗药物或其动物模型的已发表文章。搜索过程使用以下关键词:“黑籽”，“黑籽”，“黑孜然”和“百里香醌”结合“骨关节炎”进行。最后，剩下14篇文章，包括5项干预临床试验，2项人体研究和7项动物研究。五项干预研究中有四项表明，给药可减轻疼痛强度。在另一项临床试验中，在OA患者的疼痛缓解方面，sativa与对照组之间没有差异。研究表明，TQ作为芥蓝的主要生物活性物质，具有抗炎和保护软骨的作用。证据证实了芥蓝在OA患者治疗中的抗炎和软骨保护作用。考虑到上述研究均未发现明显的过敏反应等不良反应，与非甾体类抗炎药等镇痛药相比，该物质可作为缓解OA疼痛的安全辅助治疗。
{"title":"Role of Nigella sativa L. in the Management of Osteoarthritis: A Systematic Review","authors":"Mojdeh Ghamari, Masoumeh Salari, Mandana Khodashahi","doi":"10.18502/tim.v8i3.13714","DOIUrl":"https://doi.org/10.18502/tim.v8i3.13714","url":null,"abstract":"Because of the anti-inflammatory properties of thymoquinone (TQ), as the main bioactive substance of Nigella sativa L., this systematic review aimed at assessing the therapeutic effects of N. sativa and its main bioactive substance in the management of patients with osteoarthritis (OA) based on the in vivo, in vitro, and in clinical studies. The methodology was adjusted based on the Cochrane Handbook recommendations. All published articles focusing on N. sativa as a therapeutic agent for the treatment of OA or its animal model were searched up to 20 April 2022 in PubMed, Medline, Web of Sciences, and Scopus databases. The search process was carried out using the following keywords: \"Nigella sativa\", \"Black seed', \"Black cumin\", and \"Thymoquinone\" in combination with \"Osteoarthritis\". Finally, 14 articles remained, including five intervention clinical trial, two human studies, and seven animal studies. Four of five intervention studies showed that N. sativa administration led to relief in pain intensity. In the other clinical trial, no difference was reported between the N. sativa and control groups in terms of pain relief among OA patients. Studies demonstrated the anti-inflammatory and chondroprotective effects of TQ as the main bioactive substance of N. sativa. The evidence confirmed the anti-inflammatory and chondroprotective effects of N. sativa in the management of OA patients. Considering the lack of significant adverse effects such as allergic reaction to N. sativa in the aforementioned studies, this substance can be recommended as a safe adjuvant treatment to relieve OA pain, compared to nonsteroidal anti-inflammatory drugs and other analgesics.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical knowledge has gone through many ups and downs in its historical background. The formation of medical schools existed in different areas of Islamic territory. The purpose of this research is to introduce the character of Isaaq Ibn Imran and the impact of his works on the evolution of medical knowledge in North Africa. The present paper was written with a descriptive-analytical approach and a library method. After collecting relevant information, historical sources were analyzed and classified. To get more information, many articles were read and a search was made in electronic databases. The knowledge and attitude of Muslim physicians were different according to the climatic characteristics. Social and political conditions were effective in the production of various works as well. Isaaq Ibn Imran (d. 892) was one of the physicians born in Baghdad, who played an important role in the expansion of medical knowledge and philosophy in North Africa. The results of the research indicate that Ibn Imran is considered sheikh al-Attiba and a specialist physician, a pioneer of the school of medicine and pharmacy in North Africa. From all the works and writings that have been remembered by him in the field of medicine, he can be mentioned as a specialist in mental diseases among Muslims. His most important writing is the treatise "Fi al-Mālikholiā" among the first works on the treatment of mental disorders and the description of its therapeutic drugs, which there was no history of writing such a book by Muslim physicians.
{"title":"Isaaq Ibn Imran, A Physician of North Africa with a Look at His First Independent Work \"Fi al-Mālikholiā\" (Melancholy)","authors":"Mohammad Hashemimehr, Mahboobeh Farkhondehzadeh","doi":"10.18502/tim.v8i3.13718","DOIUrl":"https://doi.org/10.18502/tim.v8i3.13718","url":null,"abstract":"Medical knowledge has gone through many ups and downs in its historical background. The formation of medical schools existed in different areas of Islamic territory. The purpose of this research is to introduce the character of Isaaq Ibn Imran and the impact of his works on the evolution of medical knowledge in North Africa. The present paper was written with a descriptive-analytical approach and a library method. After collecting relevant information, historical sources were analyzed and classified. To get more information, many articles were read and a search was made in electronic databases. The knowledge and attitude of Muslim physicians were different according to the climatic characteristics. Social and political conditions were effective in the production of various works as well. Isaaq Ibn Imran (d. 892) was one of the physicians born in Baghdad, who played an important role in the expansion of medical knowledge and philosophy in North Africa. The results of the research indicate that Ibn Imran is considered sheikh al-Attiba and a specialist physician, a pioneer of the school of medicine and pharmacy in North Africa. From all the works and writings that have been remembered by him in the field of medicine, he can be mentioned as a specialist in mental diseases among Muslims. His most important writing is the treatise \"Fi al-Mālikholiā\" among the first works on the treatment of mental disorders and the description of its therapeutic drugs, which there was no history of writing such a book by Muslim physicians.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naprapathy is an integrative medicine therapy that can aide in decreasing medical costs by assisting in pain management and improving overall function in individuals experiencing musculoskeletal pain and dysfunction. Naprapathy was developed in 1907 by Oakley Smith. Naprapathy treats musculoskeletal pathologies by using connective tissue tension found within the vertebral column and peripheral joints with an emphasis on ligamentous tension. Current scientific studies have emphasized the role of fascia and its importance to manual medicine. Fascia has many properties including assisting in venous return, dissipation of tensional stress, pain, proprioception, and coordination of movement. Fascial restrictions occur when there is lack of glide between the fascial layers. These restrictions can be released with the utilization of different methods of fascial manipulation. Compared to other manual therapies, naprapathy has its own set of diagnostic tools and protocols emphasizing the treatment of fascial restrictions, stretching of buckled ligaments and tracing tension to the musculoskeletal system. It includes within its scope of practice dietary counseling in conjunction with vitamin and mineral supplementation for assistance in decreasing pain and inflammation. Several organizations and schools throughout the U.S. and internationally promote the discipline of naprapathy with the goal of advancing the profession by preparing practitioners at the doctorate level, treating patients, and using evidence-based medicine providing support for the efficacy of naprapathy and its interventions.
{"title":"Soft Tissue Manipulation and Naprapathy: Origins and Current Practices","authors":"Miranda Budagher-Marshall, Dominique Alò","doi":"10.18502/tim.v8i3.13717","DOIUrl":"https://doi.org/10.18502/tim.v8i3.13717","url":null,"abstract":"Naprapathy is an integrative medicine therapy that can aide in decreasing medical costs by assisting in pain management and improving overall function in individuals experiencing musculoskeletal pain and dysfunction. Naprapathy was developed in 1907 by Oakley Smith. Naprapathy treats musculoskeletal pathologies by using connective tissue tension found within the vertebral column and peripheral joints with an emphasis on ligamentous tension. Current scientific studies have emphasized the role of fascia and its importance to manual medicine. Fascia has many properties including assisting in venous return, dissipation of tensional stress, pain, proprioception, and coordination of movement. Fascial restrictions occur when there is lack of glide between the fascial layers. These restrictions can be released with the utilization of different methods of fascial manipulation. Compared to other manual therapies, naprapathy has its own set of diagnostic tools and protocols emphasizing the treatment of fascial restrictions, stretching of buckled ligaments and tracing tension to the musculoskeletal system. It includes within its scope of practice dietary counseling in conjunction with vitamin and mineral supplementation for assistance in decreasing pain and inflammation. Several organizations and schools throughout the U.S. and internationally promote the discipline of naprapathy with the goal of advancing the profession by preparing practitioners at the doctorate level, treating patients, and using evidence-based medicine providing support for the efficacy of naprapathy and its interventions.","PeriodicalId":52659,"journal":{"name":"Traditional and Integrative Medicine","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135199669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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