Background: Extirpative uterine surgeries for near-miss events are usually the last resort when other conservative measures fail. Emergency obstetric hysterectomy (EOH) may still have a significant role where there are limited options. Objectives: To determine the prevalence of EOH, the associated factors and the foeto-maternal outcome at the Olabisi Onabanjo University Teaching Hospital, Nigeria. Methods: This was a retrospective observational study covering seven years (January 2010 to December 2016). The case records of patients who had EOH during this period were retrieved for data extraction. Results: There were 5, 608 deliveries and 31 cases requiring EOH giving a prevalence rate of 31/5,608 (0.55%). The mean age of the patients was 30.3±4.2 years, while the mean gestational age at delivery was 36.3±5.1 weeks. Most of the patients 16/25 (64.0%) were of higher parity (>3), and 12/25 (48%) of the patients were within the age bracket of 25-34 years. Subtotal hysterectomy was the most common procedure (18; 72.0%), and ruptured uterus was the main indication for EOH (40.0%). The two most common interventions that were critical to survival included massive blood transfusion (24.0%) and Intensive Care Unit admission (20%). Two (8%) maternal deaths and 58.3% perinatal mortality were recorded. Conclusion: EOH is still relatively frequently performed at this centre due to the high incidence of a ruptured uterus. Efforts should be made to increase the proportion of deliveries attended by skilled personnel and improve the capacity of lower level hospitals for comprehensive emergency obstetric care.
{"title":"A Seven-Year Review of Emergency Obstetric Hysterectomy in a Nigerian Tertiary Institution","authors":"O. Jagun, Gbenga Victor Nathaniel, A. K. Akinseku","doi":"10.30442/AHR.0501-7-37","DOIUrl":"https://doi.org/10.30442/AHR.0501-7-37","url":null,"abstract":"Background: Extirpative uterine surgeries for near-miss events are usually the last resort when other conservative measures fail. Emergency obstetric hysterectomy (EOH) may still have a significant role where there are limited options. Objectives: To determine the prevalence of EOH, the associated factors and the foeto-maternal outcome at the Olabisi Onabanjo University Teaching Hospital, Nigeria. Methods: This was a retrospective observational study covering seven years (January 2010 to December 2016). The case records of patients who had EOH during this period were retrieved for data extraction. Results: There were 5, 608 deliveries and 31 cases requiring EOH giving a prevalence rate of 31/5,608 (0.55%). The mean age of the patients was 30.3±4.2 years, while the mean gestational age at delivery was 36.3±5.1 weeks. Most of the patients 16/25 (64.0%) were of higher parity (>3), and 12/25 (48%) of the patients were within the age bracket of 25-34 years. Subtotal hysterectomy was the most common procedure (18; 72.0%), and ruptured uterus was the main indication for EOH (40.0%). The two most common interventions that were critical to survival included massive blood transfusion (24.0%) and Intensive Care Unit admission (20%). Two (8%) maternal deaths and 58.3% perinatal mortality were recorded. Conclusion: EOH is still relatively frequently performed at this centre due to the high incidence of a ruptured uterus. Efforts should be made to increase the proportion of deliveries attended by skilled personnel and improve the capacity of lower level hospitals for comprehensive emergency obstetric care.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43988266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The Post-Operative Symptom Severity (Posse) score is useful in the assessment of patients after third molar surgery. Objective: To evaluate patients' perceptions of quality of life after surgical extraction of an impacted mandibular third molar by comparing their Post-operative Symptom Severity (PoSSe) scores at Post-operative Weeks (POW) 1 and 4. Methods: Seventy patients (age 18 to 35 years) at the Out-Patient Department were enrolled in a prospective study prior to surgical removal of third molars. Each patient was given a PoSSe questionnaire to be completed at POW 1 and POW 4. The scale assessed recovery in seven key domains on patients’ subjective feeling about pain, eating, speech, sensation, appearance, sickness and interference with daily activities. Results: All but one patient returned completely filled questionnaires. The mean age of the study population was 25.7 ± 4.5 years. The mean PoSSe score at POW 1 and POW 4 were 35.0 ± 7.2 and 33.2 ± 6.9 respectively with statistically significant difference (p = 0.010). The PoSSe score was higher among males compared to females at POW 1 (37.2 ± 7.6 vs 33.5 ± 6.6) and also higher among males at POW 4 (33.8 ± 9.4 vs 32.7 ± 4.6). Conclusion: The severity of symptoms was perceived to be worse at POW 1 when compared to POW4 but the symptoms were still severe at POW4. There is a need for surgeons need to pay more attention to management of symptoms in the post-operative intermediate period.
{"title":"Comparison of Post-Operative Symptom Severity (PoSSe) Scores in patients undergoing Mandibular Third Molar surgery in Ile-Ife, Nigeria","authors":"Ogundipe Ok, A. Njokanma","doi":"10.30442/AHR.0501-4-34","DOIUrl":"https://doi.org/10.30442/AHR.0501-4-34","url":null,"abstract":"Background: The Post-Operative Symptom Severity (Posse) score is useful in the assessment of patients after third molar surgery. Objective: To evaluate patients' perceptions of quality of life after surgical extraction of an impacted mandibular third molar by comparing their Post-operative Symptom Severity (PoSSe) scores at Post-operative Weeks (POW) 1 and 4. Methods: Seventy patients (age 18 to 35 years) at the Out-Patient Department were enrolled in a prospective study prior to surgical removal of third molars. Each patient was given a PoSSe questionnaire to be completed at POW 1 and POW 4. The scale assessed recovery in seven key domains on patients’ subjective feeling about pain, eating, speech, sensation, appearance, sickness and interference with daily activities. Results: All but one patient returned completely filled questionnaires. The mean age of the study population was 25.7 ± 4.5 years. The mean PoSSe score at POW 1 and POW 4 were 35.0 ± 7.2 and 33.2 ± 6.9 respectively with statistically significant difference (p = 0.010). The PoSSe score was higher among males compared to females at POW 1 (37.2 ± 7.6 vs 33.5 ± 6.6) and also higher among males at POW 4 (33.8 ± 9.4 vs 32.7 ± 4.6). Conclusion: The severity of symptoms was perceived to be worse at POW 1 when compared to POW4 but the symptoms were still severe at POW4. There is a need for surgeons need to pay more attention to management of symptoms in the post-operative intermediate period.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42066828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Thyroid disorders constitute the second most common endocrine disorders worldwide, but they are less commonly researched in this environment due to low cost-effectiveness. Objective: To study the spectrum of thyroid disorders at the Endocrinology Clinic of a tertiary health facility in Sagamu, South-west, Nigeria, over two years. Method: This retrospective study was conducted on all new clinic attendees with thyroid disorders between January 2016 and December 2017. The data retrieved included clinical data, results of thyroid function tests and thyroid ultrasonographic scan. The patients were grouped clinically into euthyroid, hypothyroid and thyrotoxic states. Results: A total of 93 thyroid cases were seen, and this constituted 13.64% of all new endocrine consultations (682 patients). The mean age (±SD; range) of the patients was 37.6 (13.6; 15-78) years. Majority of the patients were females with a female-to-male ratio of 4.5:1. Out of these, 77.4% had Goitrous enlargement. Thyrotoxicosis was the most common form of thyroid dysfunction, (72; 77.40%), mainly due to hyperthyroidism from Graves’ disease (50; 69.44%), followed by toxic multinodular goitre (12; 16.67%), toxic solitary nodular goiter (5; 6.94%) and others (5; 6.95 %). Hypothyroidism constituted 10.75% while euthyroid goitre constituted 11.85% of all thyroid cases. Conclusion: Auto-immune thyroid disease remains the most common thyroid disorder among endocrine clinic attendees. There is a need for further studies to elucidate the likely aetiologies.
{"title":"The spectrum of thyroid disorders at the Endocrine Clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu, South-west, Nigeria","authors":"A. Ale, O. Aloro, A. Adepoju, O. Odusan","doi":"10.30442/AHR.0501-9-39","DOIUrl":"https://doi.org/10.30442/AHR.0501-9-39","url":null,"abstract":"Background: Thyroid disorders constitute the second most common endocrine disorders worldwide, but they are less commonly researched in this environment due to low cost-effectiveness. Objective: To study the spectrum of thyroid disorders at the Endocrinology Clinic of a tertiary health facility in Sagamu, South-west, Nigeria, over two years. Method: This retrospective study was conducted on all new clinic attendees with thyroid disorders between January 2016 and December 2017. The data retrieved included clinical data, results of thyroid function tests and thyroid ultrasonographic scan. The patients were grouped clinically into euthyroid, hypothyroid and thyrotoxic states. Results: A total of 93 thyroid cases were seen, and this constituted 13.64% of all new endocrine consultations (682 patients). The mean age (±SD; range) of the patients was 37.6 (13.6; 15-78) years. Majority of the patients were females with a female-to-male ratio of 4.5:1. Out of these, 77.4% had Goitrous enlargement. Thyrotoxicosis was the most common form of thyroid dysfunction, (72; 77.40%), mainly due to hyperthyroidism from Graves’ disease (50; 69.44%), followed by toxic multinodular goitre (12; 16.67%), toxic solitary nodular goiter (5; 6.94%) and others (5; 6.95 %). Hypothyroidism constituted 10.75% while euthyroid goitre constituted 11.85% of all thyroid cases. Conclusion: Auto-immune thyroid disease remains the most common thyroid disorder among endocrine clinic attendees. There is a need for further studies to elucidate the likely aetiologies.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42592153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Ayoade, B. Salami, K. Oritogun, O. Ojo, H. Ebili, O. Fatungase
Background: Breast cancer is the most common female malignancy in Nigeria. Neoadjuvant chemotherapy is the first line treatment for locally advanced breast cancer. The advancement of many cancers is accompanied by inflammation, and inflammatory cells play an essential role in the progression. Objective: To determine if haematological parameters can predict the responsiveness of breast cancer to neoadjuvant chemotherapy regime. Method: A prospective cohort study of all breast cancer patients who had neoadjuvant chemotherapy between July 2017 and December 2018 was carried out. Haematological parameters of red cell count (RCC), white cell count(WCC), neutrophil count (NC), lymphocyte count (LC), platelet count (PC), red cell distribution width (RCDW), mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were measured. Response to chemotherapy was assessed by measuring the longest diameter of the lump and largest lymph node and applying the UICC criteria. Results: Thirty-five females with breast cancer with the age range of 33-82 years and mean age of 48 ± 11 years were studied. The overall clinical response rate was 80% consisting of 40% complete clinical response, 40% partial clinical response, 8.6% stable disease and 11.4% progressive disease. Eleven (78.6%) with PLR values below average had good clinical response while 21.4% of those with PLR value above average had a good clinical response (χ2 = 8.4, p = 0.006) Conclusion: The study showed that PLR is associated with complete clinical response to neoadjuvant chemotherapy and should be used as part of routine assessment before chemotherapy.
{"title":"Blood cellular markers of inflammation in Breast Cancer and response to Neoadjuvant Chemotherapy","authors":"B. Ayoade, B. Salami, K. Oritogun, O. Ojo, H. Ebili, O. Fatungase","doi":"10.30442/AHR.0501-13-43","DOIUrl":"https://doi.org/10.30442/AHR.0501-13-43","url":null,"abstract":"Background: Breast cancer is the most common female malignancy in Nigeria. Neoadjuvant chemotherapy is the first line treatment for locally advanced breast cancer. The advancement of many cancers is accompanied by inflammation, and inflammatory cells play an essential role in the progression. Objective: To determine if haematological parameters can predict the responsiveness of breast cancer to neoadjuvant chemotherapy regime. Method: A prospective cohort study of all breast cancer patients who had neoadjuvant chemotherapy between July 2017 and December 2018 was carried out. Haematological parameters of red cell count (RCC), white cell count(WCC), neutrophil count (NC), lymphocyte count (LC), platelet count (PC), red cell distribution width (RCDW), mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were measured. Response to chemotherapy was assessed by measuring the longest diameter of the lump and largest lymph node and applying the UICC criteria. Results: Thirty-five females with breast cancer with the age range of 33-82 years and mean age of 48 ± 11 years were studied. The overall clinical response rate was 80% consisting of 40% complete clinical response, 40% partial clinical response, 8.6% stable disease and 11.4% progressive disease. Eleven (78.6%) with PLR values below average had good clinical response while 21.4% of those with PLR value above average had a good clinical response (χ2 = 8.4, p = 0.006) Conclusion: The study showed that PLR is associated with complete clinical response to neoadjuvant chemotherapy and should be used as part of routine assessment before chemotherapy.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44227529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Femi-Adebayo, O. Adejumo, Bisola I Adebayo, A. Airauhi, V. Adepoju
Background: The World Health Organization prescribed that Youth-Friendly health services must be accessible, acceptable, equitable, efficient, effective, comprehensive and appropriate to meet the health needs of young people. Objective: To compare the clients’ and service providers’ assessment of services offered at the public and Non-Governmental Organization (NGO) Youth Friendly facilities (YFF) in Lagos Nigeria. Methods: A mixed method approach was used. Structured questionnaires were administered on youths (294 from public and 273 from NGO YFF) from ten (5 public and 5 NGO) YFF. Ten key informant interviews with service providers were also conducted between March 1st and December 31st 2014. SPSS version 22 was used to analyze quantitative data while thematic analysis of interviews with service providers was done. Results: Youths who utilized the public YFF had 60% chance (AOR 1.6, 95%CI 1.3 – 2.5, p= 0.005) of experiencing longer waiting times, 80% chance (AOR 1.8, 95%CI 1.2 – 2.8, p=0.004) of being counseled in a separate room and over two-fold chance (AOR 2.3, 95%CI 1.7 – 3.3, p <0.001) of having free services. Sexual and reproductive health was the major complaint area of the youths while funding was the major challenge of service providers at both the public and NGO YFF. Conclusion: To address the needs of the youths, there is a need to provide more funds and provide necessary logistics required by YFF.
{"title":"Clients and service providers’ assessment of Public and Non-Governmental Youth-Friendly Health Services in Lagos Nigeria: A mixed method approach","authors":"T. Femi-Adebayo, O. Adejumo, Bisola I Adebayo, A. Airauhi, V. Adepoju","doi":"10.30442/AHR.0501-11-41","DOIUrl":"https://doi.org/10.30442/AHR.0501-11-41","url":null,"abstract":"Background: The World Health Organization prescribed that Youth-Friendly health services must be accessible, acceptable, equitable, efficient, effective, comprehensive and appropriate to meet the health needs of young people. Objective: To compare the clients’ and service providers’ assessment of services offered at the public and Non-Governmental Organization (NGO) Youth Friendly facilities (YFF) in Lagos Nigeria. Methods: A mixed method approach was used. Structured questionnaires were administered on youths (294 from public and 273 from NGO YFF) from ten (5 public and 5 NGO) YFF. Ten key informant interviews with service providers were also conducted between March 1st and December 31st 2014. SPSS version 22 was used to analyze quantitative data while thematic analysis of interviews with service providers was done. Results: Youths who utilized the public YFF had 60% chance (AOR 1.6, 95%CI 1.3 – 2.5, p= 0.005) of experiencing longer waiting times, 80% chance (AOR 1.8, 95%CI 1.2 – 2.8, p=0.004) of being counseled in a separate room and over two-fold chance (AOR 2.3, 95%CI 1.7 – 3.3, p <0.001) of having free services. Sexual and reproductive health was the major complaint area of the youths while funding was the major challenge of service providers at both the public and NGO YFF. Conclusion: To address the needs of the youths, there is a need to provide more funds and provide necessary logistics required by YFF.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46281829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontotemporal dementia (FTD), otherwise known as Pick’s disease, is a clinically heterogeneous group of sporadic and familial neurodegenerative diseases. These conditions are characterized by dementia, behavioural and language dysfunction and loss of executive skills resulting from the degeneration of the frontal and temporal lobes. Although reversible causes of dementia are always sought during the evaluation of patients with progressive cognitive decline, the occurrence of a reversible aetiology may distract from evaluating for neurodegenerative causes of dementia. This report is about a 66-year old man with features of FTD and superimposed chronic subdural haematoma.
{"title":"Pick’s disease and subdural haematoma: A diagnostic red herring","authors":"P. Adebayo, F. Taiwo, Fatma A. Bakshi, S. Nur","doi":"10.30442/AHR.0501-15-45","DOIUrl":"https://doi.org/10.30442/AHR.0501-15-45","url":null,"abstract":"Frontotemporal dementia (FTD), otherwise known as Pick’s disease, is a clinically heterogeneous group of sporadic and familial neurodegenerative diseases. These conditions are characterized by dementia, behavioural and language dysfunction and loss of executive skills resulting from the degeneration of the frontal and temporal lobes. Although reversible causes of dementia are always sought during the evaluation of patients with progressive cognitive decline, the occurrence of a reversible aetiology may distract from evaluating for neurodegenerative causes of dementia. This report is about a 66-year old man with features of FTD and superimposed chronic subdural haematoma.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45393828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The incidence of neonatal macrosomia is on the increase in many parts of the world. The impact of the condition on baby and child health has not received adequate research attention. Objective: To determine the prevalence, baby and maternal characteristics, the pattern of neonatal morbidity and perinatal outcome of macrosomia. Methods: A retrospective study of all singleton deliveries with birth weight ≥ 4.0 kg was conducted at a tertiary facility in the south-western part of Nigeria between January 2013 and December 2014. Results: Eighty-eight newborn babies were macrosomic out of 1854 deliveries, resulting in a prevalence rate of 4.7%. The male-to-female ratio was 1: 0.54, while the mean (±SD) birth weight was 4.23 ± 0.29 kg. There was no significant difference in the mean birth weights of the male and female babies (t = 1.24, p = 0.218). The mean maternal age was 31.7 ± 5.1 years. Multiparous mothers had the highest proportion of macrosomic babies, while a majority of mothers (77.3%) were either overweight or obese. One-minute Apgar score <7 was observed among 28 (31.8%) babies. Twenty-three (26.1%) babies were hospitalized for further management. Birth asphyxia, hypoglycaemia and hyperbilirubinaemia were the leading morbidities. The perinatal mortality rate for macrosomic babies was 102.2 per 1000 total births. Conclusion: The incidence of neonatal macrosomia is relatively low in our study population but falls within the range of prevalence rates reported from other parts of the country. Birth asphyxia, hypoglycaemia and hyperbilirubinemia are common morbidities among affected babies.
{"title":"Neonatal macrosomia and associated morbidities in Sagamu, Nigeria","authors":"O. Ogunfowora, T. Ogunlesi, V. Ayeni, T. Shorunmu","doi":"10.30442/AHR.0501-3-33","DOIUrl":"https://doi.org/10.30442/AHR.0501-3-33","url":null,"abstract":"Background: The incidence of neonatal macrosomia is on the increase in many parts of the world. The impact of the condition on baby and child health has not received adequate research attention. Objective: To determine the prevalence, baby and maternal characteristics, the pattern of neonatal morbidity and perinatal outcome of macrosomia. Methods: A retrospective study of all singleton deliveries with birth weight ≥ 4.0 kg was conducted at a tertiary facility in the south-western part of Nigeria between January 2013 and December 2014. Results: Eighty-eight newborn babies were macrosomic out of 1854 deliveries, resulting in a prevalence rate of 4.7%. The male-to-female ratio was 1: 0.54, while the mean (±SD) birth weight was 4.23 ± 0.29 kg. There was no significant difference in the mean birth weights of the male and female babies (t = 1.24, p = 0.218). The mean maternal age was 31.7 ± 5.1 years. Multiparous mothers had the highest proportion of macrosomic babies, while a majority of mothers (77.3%) were either overweight or obese. One-minute Apgar score <7 was observed among 28 (31.8%) babies. Twenty-three (26.1%) babies were hospitalized for further management. Birth asphyxia, hypoglycaemia and hyperbilirubinaemia were the leading morbidities. The perinatal mortality rate for macrosomic babies was 102.2 per 1000 total births. Conclusion: The incidence of neonatal macrosomia is relatively low in our study population but falls within the range of prevalence rates reported from other parts of the country. Birth asphyxia, hypoglycaemia and hyperbilirubinemia are common morbidities among affected babies.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44009048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Progressive Familial Intra-hepatic Cholestasis (PFIC) is a group of heterogeneous, autosomal recessive disorders characterized by cholestasis, jaundice and mutilating pruritus, mostly in infancy. The incidence of PFIC ranges from 1:50,000 to 1:100,000. There are three subtypes; Types 1 and 2 typically present in the neonatal period and early infancy while Type 3 can present in early infancy, childhood or adolescence. This report is about a 6-year old Nigerian girl who presented with jaundice and severe pruritus of one-month duration and abdominal pain of a week duration. The symptoms were preceded by ingestion of Atropine meant for ocular examination two days earlier. She was well-nourished, deeply icteric, had generalized healing scratch marks and hepatomegaly. The laboratory findings included conjugated hyperbilirubinaemia, moderately elevated liver transaminases and Gamma-Glutamyltransferase enzymes. She was managed for PFIC3 using oral ursodeoxycholic acid with complete resolution of the disease.
{"title":"A suspected case of Progressive Familial Intra-hepatic Cholestasis in a Six-Year-Old Nigerian Child","authors":"A. O. Atimati, P. Ikhurionan","doi":"10.30442/AHR.0501-14-44","DOIUrl":"https://doi.org/10.30442/AHR.0501-14-44","url":null,"abstract":"Progressive Familial Intra-hepatic Cholestasis (PFIC) is a group of heterogeneous, autosomal recessive disorders characterized by cholestasis, jaundice and mutilating pruritus, mostly in infancy. The incidence of PFIC ranges from 1:50,000 to 1:100,000. There are three subtypes; Types 1 and 2 typically present in the neonatal period and early infancy while Type 3 can present in early infancy, childhood or adolescence. This report is about a 6-year old Nigerian girl who presented with jaundice and severe pruritus of one-month duration and abdominal pain of a week duration. The symptoms were preceded by ingestion of Atropine meant for ocular examination two days earlier. She was well-nourished, deeply icteric, had generalized healing scratch marks and hepatomegaly. The laboratory findings included conjugated hyperbilirubinaemia, moderately elevated liver transaminases and Gamma-Glutamyltransferase enzymes. She was managed for PFIC3 using oral ursodeoxycholic acid with complete resolution of the disease.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45345418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Osunkalu, Alani S Akanmu, Aderonke Shakirat Lawal Folorunsho
Background: The health benefits of blood donation are well known. However, the overall effect of long term regular blood donation on body iron store and blood pressure need to be evaluated among voluntary blood donors. Objective: To determine the effect of long term, regular blood donation on body iron store and blood pressure among regular voluntary non-remunerated blood donors in Lagos, Nigeria. Methods: Consenting adult blood donors (n = 320), ranging from the first time to regular blood donors were studied over six months. Supine blood pressure (BP) readings were taken twice at 30 minutes interval with a mercury sphygmomanometer. Venous whole blood was drawn into EDTA anti-coagulated and plain tubes for haematological parameters and serum ferritin estimation using Enzyme-linked Immunosorbent Assay (ELISA) method. Results: The mean serum ferritin levels declined significantly from 95.5ng/mL among first time donors to 68.9ng/mL among Category III donors (p = 0.035). Male voluntary blood donors had increased risk of low serum ferritin level (OR = 5.02; 95%CI= 1.12-22.51; p = 0.035). Lower values of serum ferritin were recorded more frequently among donors within the 21-30 year age category (OR = 1.54; 95%CI = 1.0-2.71; p= 0.042). Long term regular voluntary blood donation was associated with significant reduction in mean systolic blood pressure (p = 0.01). Conclusion: Long term blood donation resulted in the reduction of blood pressure. Progressive increase in the duration of donation resulted in reduced iron stores even as haemoglobin concentration levels remained acceptable for blood donation.
{"title":"Serum Ferritin and Blood Pressure modulation in first-time and regular blood donors","authors":"O. Osunkalu, Alani S Akanmu, Aderonke Shakirat Lawal Folorunsho","doi":"10.30442/AHR.0501-1-31","DOIUrl":"https://doi.org/10.30442/AHR.0501-1-31","url":null,"abstract":"Background: The health benefits of blood donation are well known. However, the overall effect of long term regular blood donation on body iron store and blood pressure need to be evaluated among voluntary blood donors. Objective: To determine the effect of long term, regular blood donation on body iron store and blood pressure among regular voluntary non-remunerated blood donors in Lagos, Nigeria. Methods: Consenting adult blood donors (n = 320), ranging from the first time to regular blood donors were studied over six months. Supine blood pressure (BP) readings were taken twice at 30 minutes interval with a mercury sphygmomanometer. Venous whole blood was drawn into EDTA anti-coagulated and plain tubes for haematological parameters and serum ferritin estimation using Enzyme-linked Immunosorbent Assay (ELISA) method. Results: The mean serum ferritin levels declined significantly from 95.5ng/mL among first time donors to 68.9ng/mL among Category III donors (p = 0.035). Male voluntary blood donors had increased risk of low serum ferritin level (OR = 5.02; 95%CI= 1.12-22.51; p = 0.035). Lower values of serum ferritin were recorded more frequently among donors within the 21-30 year age category (OR = 1.54; 95%CI = 1.0-2.71; p= 0.042). Long term regular voluntary blood donation was associated with significant reduction in mean systolic blood pressure (p = 0.01). Conclusion: Long term blood donation resulted in the reduction of blood pressure. Progressive increase in the duration of donation resulted in reduced iron stores even as haemoglobin concentration levels remained acceptable for blood donation.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47662124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Dipstick urinalysis is a semi-quantitative examination of the urine, which can be utilized as a screening and diagnostic tool in children. It is rapid, sensitive, easy to perform and affordable for the resource-poor environment. Objectives: To describe the pattern of urinalysis findings using urinary dipsticks and the determinants of urine abnormality among pupils in primary schools in a semi-urban area. Methods: Apparently healthy 387 pupils were recruited from 10 public and 5 private primary schools in Ikenne Local Government Area of Ogun State, Nigeria using multi-stage and proportionate sampling techniques. Data on demography, nutritional status and urinary examination were obtained using Interviewer-administered questionnaires, clinical examination and dipstick urinalysis respectively. Results: Dipstick urinalysis revealed the following; urine pH and specific gravity were normal in 98.2% and 100.0% of the pupils respectively. Protein, leukocyte esterase, nitrite, bilirubin, urobilinogen, blood and ketones were detected in 18.1%, 15.8%, 14.2%, 3.3%, 2.1%, 0.8%, and 0.5% respectively. Glucose and ascorbic acid were generally absent in the urine samples. Female gender significantly contributed to the pattern of urinalysis (leukocyte esterase and nitrites). Proteinuria was most frequent among the underweight (38/70; 54.3%). Urine abnormalities were more prevalent among pupils in public schools compared with private schools though not statistically significant, and not influenced by gender. Conclusion: Asymptomatic proteinuria and urinary tract infection are not uncommon among children. Female gender and socio-economic status play a role in the incidence of the conditions.
{"title":"Prevalence, pattern and determinants of urine abnormalities among school pupils in a semi-urban community","authors":"A. Alaje, T. Runsewe-Abiodun, O. Olawale","doi":"10.30442/AHR.0501-12-42","DOIUrl":"https://doi.org/10.30442/AHR.0501-12-42","url":null,"abstract":"Background: Dipstick urinalysis is a semi-quantitative examination of the urine, which can be utilized as a screening and diagnostic tool in children. It is rapid, sensitive, easy to perform and affordable for the resource-poor environment. Objectives: To describe the pattern of urinalysis findings using urinary dipsticks and the determinants of urine abnormality among pupils in primary schools in a semi-urban area. Methods: Apparently healthy 387 pupils were recruited from 10 public and 5 private primary schools in Ikenne Local Government Area of Ogun State, Nigeria using multi-stage and proportionate sampling techniques. Data on demography, nutritional status and urinary examination were obtained using Interviewer-administered questionnaires, clinical examination and dipstick urinalysis respectively. Results: Dipstick urinalysis revealed the following; urine pH and specific gravity were normal in 98.2% and 100.0% of the pupils respectively. Protein, leukocyte esterase, nitrite, bilirubin, urobilinogen, blood and ketones were detected in 18.1%, 15.8%, 14.2%, 3.3%, 2.1%, 0.8%, and 0.5% respectively. Glucose and ascorbic acid were generally absent in the urine samples. Female gender significantly contributed to the pattern of urinalysis (leukocyte esterase and nitrites). Proteinuria was most frequent among the underweight (38/70; 54.3%). Urine abnormalities were more prevalent among pupils in public schools compared with private schools though not statistically significant, and not influenced by gender. Conclusion: Asymptomatic proteinuria and urinary tract infection are not uncommon among children. Female gender and socio-economic status play a role in the incidence of the conditions.","PeriodicalId":52960,"journal":{"name":"Annals of Health Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70070869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：