Pub Date : 2019-03-22DOI: 10.24125/SANAMED.V14I1.325
D. Sengul, I. Sengul
Background: The goal is to evaluate the association between the topo-sonographic polarity of the thyroid nodules and the thyroid malignancy by analyzing its effect on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), score of Strain Elastography (SE) for thyroid as Tsukuba Elasticity Score (TES), and histopathologic assessment. Material and Methods: A preliminary single-center retrospective study was carried out by including the documents of 641 consecutive eligible patients, possessing 770 thyroid nodules which undergone neck ultrasonography (US), Doppler US, SE, and US-guided-fine needle aspiration (FNA) during April 2011 to April 2017. The stiffness had been measured by TES of SE. The ability of the prediction of the malignancy by the polarity of 770 thyroid nodules considering the association between; i) TBSRTC and histopathology and ii) TES and histopathology had been evaluated. Results: Of the 770 thyroid nodules evaluated, 408 (53.0%) were located at the superior pole (Pol 1) while 362 (47.0%) were at the inferior pole (Pol 0) with 0.9046 AUC and 0.8171 AUC for the association between TBSRTC and histopathology and 0.9280 AUC and 0.7888 AUC for the association between TES and histopathology, respectively. However, those difference were not significant for Pol 1, topographically. Conclusion : The topograghic and sonographic polarity of the thyroid nodules may not be useful for estimating the thyroid malignancy by using the association between TBSRTC and histopathology with TES and histopathology. However, the association with Pol 1, the superior thyroid pole, was stronger though the difference was not significant.
{"title":"EFFECT OF ANATOMO-TOPOGRAPHIC AND SONOGRAPHIC POLARITY OF THE THYROID NODULES ON THE THYROID MALIGNANCY BY EVALUATING ITS IMPRESSION ON THE RELATIONSHIP BETWEEN THE BETHESDA SYSTEM, TBSRTC, STRAIN ELASTOGRAPHY SCORE AND THE THYROID HISTOPATHOLOGY","authors":"D. Sengul, I. Sengul","doi":"10.24125/SANAMED.V14I1.325","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.325","url":null,"abstract":"Background: The goal is to evaluate the association between the topo-sonographic polarity of the thyroid nodules and the thyroid malignancy by analyzing its effect on The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), score of Strain Elastography (SE) for thyroid as Tsukuba Elasticity Score (TES), and histopathologic assessment. Material and Methods: A preliminary single-center retrospective study was carried out by including the documents of 641 consecutive eligible patients, possessing 770 thyroid nodules which undergone neck ultrasonography (US), Doppler US, SE, and US-guided-fine needle aspiration (FNA) during April 2011 to April 2017. The stiffness had been measured by TES of SE. The ability of the prediction of the malignancy by the polarity of 770 thyroid nodules considering the association between; i) TBSRTC and histopathology and ii) TES and histopathology had been evaluated. Results: Of the 770 thyroid nodules evaluated, 408 (53.0%) were located at the superior pole (Pol 1) while 362 (47.0%) were at the inferior pole (Pol 0) with 0.9046 AUC and 0.8171 AUC for the association between TBSRTC and histopathology and 0.9280 AUC and 0.7888 AUC for the association between TES and histopathology, respectively. However, those difference were not significant for Pol 1, topographically. Conclusion : The topograghic and sonographic polarity of the thyroid nodules may not be useful for estimating the thyroid malignancy by using the association between TBSRTC and histopathology with TES and histopathology. However, the association with Pol 1, the superior thyroid pole, was stronger though the difference was not significant.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49137924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.288
G. Cansabuncu, N. Şahin, Y. Akalın, N. Çevik, G. Özkaya
Objectives: To evaluate the radiological, histological and mechanical effects on osteoporotic fracture healing of single-dose zoledronic acid (ZA) applied to an animal model with an experimentally created osteoporotic bone fracture. Methods: A total of 14 adult, female New Zealand rabbits, aged 5-6 months were used in the study. Bone mineral density (BMD) values were calculated from bone densitometry measurements and recorded. Bilateral ovariectomy was then applied to all the rabbits. At 10 weeks after ovariectomy, bone densitometry was again performed on all the animals and the BMD values were compared. Osteoporosis was accepted as having developed in animals determined with a reduction of 28% in BMD values. After the placement of a K-wire intramedullarly in the femurs of the rabbits, a closed fracture was created with the standard method. The animals were then randomly separated into 2 groups as the zoledronic acid group (ZAG) and the control group (CG). An infusion of 0.1mg/kg ZA was administered to the ZAG animals from the ear vein. With visualisation of bone union rabbits were sacrificed by decapitation. Radiological, mechanical and histological assesments were then applied. Results: In the histological evaluation, the mean histological score was determined as 5.00 in the ZAG and 3.00 in the CG. The difference between the groups was found to be statistically significant (p<0.001). In the radiological evaluation, the mean score was 7.00 in the ZAG and 6.25 in the CG. Even though higher points were obtained by the ZAG in the inter-observer evaluations, the difference between the groups was not statistically significant (p=0.073). In the mechanical evaluation, the elasticity collapse in negative proportion to rigidity was measured as 2.91 mm in the ZAG and 3.96mm in the CG (p=0.686). The rigidity data of the ZAG were higher in the mechanical tests but the difference between the groups was not statistically significant (p=0.086). Conclusion: As the results of the study showed that the ZAG had higher values than those of the CG in all the histological, mechanical and radiological evaluations, the application of a single dose of ZA can be considered to increase the healing of osteoporotic fractures.
目的:评价单剂量唑来膦酸(ZA)对实验性骨质疏松性骨折动物模型的放射学、组织学和力学影响。方法:选用5 ~ 6月龄成年雌性新西兰兔14只。骨密度(BMD)值由骨密度测量计算并记录。所有家兔均行双侧卵巢切除术。在卵巢切除后10周，再次对所有动物进行骨密度测定并比较骨密度值。骨质疏松症被认为是在骨密度降低28%的动物中发生的。在兔股骨髓内植入k针后，按标准方法形成闭合骨折。将实验动物随机分为唑来膦酸组(ZAG)和对照组(CG)。ZAG动物经耳静脉滴注0.1mg/kg ZA。在骨愈合目视下，采用斩首处死家兔。然后进行放射学、力学和组织学评估。结果:在组织学评价中，ZAG的平均组织学评分为5.00,CG的平均组织学评分为3.00。组间差异有统计学意义(p<0.001)。放射学评价中，ZAG平均评分为7.00分，CG平均评分为6.25分。尽管ZAG在观察者间评价中得分较高，但两组间差异无统计学意义(p=0.073)。在力学评价中，ZAG的弹性塌陷与刚度成负比例，ZAG为2.91 mm, CG为3.96mm (p=0.686)。力学试验中ZAG的刚度数据较高，但组间差异无统计学意义(p=0.086)。结论:本研究结果显示，ZAG在组织学、力学和放射学方面的评价均高于CG，可考虑单剂量应用ZA促进骨质疏松性骨折的愈合。
{"title":"ZOLEDRONIC ACID ADMINISTRATION ENHANCES FRACTURE HEALING IN THE OSTEOPOROTIC FRACTURES IN OVARIECTOMIZED RABBITS","authors":"G. Cansabuncu, N. Şahin, Y. Akalın, N. Çevik, G. Özkaya","doi":"10.24125/SANAMED.V14I1.288","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.288","url":null,"abstract":"Objectives: To evaluate the radiological, histological and mechanical effects on osteoporotic fracture healing of single-dose zoledronic acid (ZA) applied to an animal model with an experimentally created osteoporotic bone fracture. Methods: A total of 14 adult, female New Zealand rabbits, aged 5-6 months were used in the study. Bone mineral density (BMD) values were calculated from bone densitometry measurements and recorded. Bilateral ovariectomy was then applied to all the rabbits. At 10 weeks after ovariectomy, bone densitometry was again performed on all the animals and the BMD values were compared. Osteoporosis was accepted as having developed in animals determined with a reduction of 28% in BMD values. After the placement of a K-wire intramedullarly in the femurs of the rabbits, a closed fracture was created with the standard method. The animals were then randomly separated into 2 groups as the zoledronic acid group (ZAG) and the control group (CG). An infusion of 0.1mg/kg ZA was administered to the ZAG animals from the ear vein. With visualisation of bone union rabbits were sacrificed by decapitation. Radiological, mechanical and histological assesments were then applied. Results: In the histological evaluation, the mean histological score was determined as 5.00 in the ZAG and 3.00 in the CG. The difference between the groups was found to be statistically significant (p<0.001). In the radiological evaluation, the mean score was 7.00 in the ZAG and 6.25 in the CG. Even though higher points were obtained by the ZAG in the inter-observer evaluations, the difference between the groups was not statistically significant (p=0.073). In the mechanical evaluation, the elasticity collapse in negative proportion to rigidity was measured as 2.91 mm in the ZAG and 3.96mm in the CG (p=0.686). The rigidity data of the ZAG were higher in the mechanical tests but the difference between the groups was not statistically significant (p=0.086). Conclusion: As the results of the study showed that the ZAG had higher values than those of the CG in all the histological, mechanical and radiological evaluations, the application of a single dose of ZA can be considered to increase the healing of osteoporotic fractures.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42799699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.271
Helin Sahinturk, S. Turhan, Selvi Ozlem Can, Ali Abbas Ylmaz, A. Uysalel
Objectives: In recent years, a significant increase has been observed in the prevalence of caesarean sections (CS). Although as in many other countries, CS rates in Turkey are higher than the targeted rate. This increase in the prevalence of CS also affects obstetric anaesthesia. In this study, we investigate the choice of anaesthesia among pregnant women who are scheduled for CS, as well as general anaesthesia and regional anaesthesia rates, the reasons for choosing general anaesthesia or regional anaesthesia, and the factors that affect their choices. Methods: A questionnaire consisting of 20 questions were applied to pregnant women applying for delivery by elective caesarean operation, between November 2011 to November 2012, in order to study the anaesthesia technique they prefer and the reason behind their preferences. The questionnaire was applied to pregnant women during the visit, on the day before the operation or while they were waiting in the waiting room before the CS procedure. Results : Our study revealed that age, gravida, previous type of delivery, previous anaesthesia experience, employment status, monthly income level, educational status, being given information about anaesthesia in advance, the source of information, and being diagnosed with panic disorder were all found to be influential in the decision of which type of anaesthesia to opt for. Conclusion : We have found out that the reason why pregnant women who have higher educational status, who work and have high level of monthly-income prefer regional anaesthesia method more depends on the fact that they have more information on anaesthesia method, they have more common use of the internet and the information they obtain from the people around them is not prejudiced against regional anaesthesia method. We believe that as the education levels rise in the future and the patient population becomes more aware, which will direct them to do more research, their preference rates will change.
{"title":"FACTORS AFFECTING ANAESTHESIA PREFERENCES OF THE GRAVID WOMEN WHO ARE TO DELIVER BY CAESAREAN SECTION","authors":"Helin Sahinturk, S. Turhan, Selvi Ozlem Can, Ali Abbas Ylmaz, A. Uysalel","doi":"10.24125/SANAMED.V14I1.271","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.271","url":null,"abstract":"Objectives: In recent years, a significant increase has been observed in the prevalence of caesarean sections (CS). Although as in many other countries, CS rates in Turkey are higher than the targeted rate. This increase in the prevalence of CS also affects obstetric anaesthesia. In this study, we investigate the choice of anaesthesia among pregnant women who are scheduled for CS, as well as general anaesthesia and regional anaesthesia rates, the reasons for choosing general anaesthesia or regional anaesthesia, and the factors that affect their choices. Methods: A questionnaire consisting of 20 questions were applied to pregnant women applying for delivery by elective caesarean operation, between November 2011 to November 2012, in order to study the anaesthesia technique they prefer and the reason behind their preferences. The questionnaire was applied to pregnant women during the visit, on the day before the operation or while they were waiting in the waiting room before the CS procedure. Results : Our study revealed that age, gravida, previous type of delivery, previous anaesthesia experience, employment status, monthly income level, educational status, being given information about anaesthesia in advance, the source of information, and being diagnosed with panic disorder were all found to be influential in the decision of which type of anaesthesia to opt for. Conclusion : We have found out that the reason why pregnant women who have higher educational status, who work and have high level of monthly-income prefer regional anaesthesia method more depends on the fact that they have more information on anaesthesia method, they have more common use of the internet and the information they obtain from the people around them is not prejudiced against regional anaesthesia method. We believe that as the education levels rise in the future and the patient population becomes more aware, which will direct them to do more research, their preference rates will change.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43205575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.301
S. Stojanovic, Zlatan Stojanović, Gordana Macanović, N. Banjac, Želimir Erić
Introduction and Aim: Depression in psychiatry covers a large area of mental pathology and it is one of the most complex problems of modern medicine with broad implications for the health of the individual and the society as a whole. Depression is also a frequent companion of alcohol addiction. The aim of this study was to investigate the effect of the antidepressant drug sertaline on the lenght of QT interval in depressed patients with alcohol dependence. Patients and methods : This research included male patients (older than 18 years of age) suffering from alcohol addiction, who were also diagnosed with depression, that is, depressive disorder,at the beginnig of hospitalisation, on the basis of DSM-IV (Diagnostic and statistical manual of mental disorders) criterion and positive Hamilton Rating Scale for Depression (HRSD). The study included 49 patients treated wit antidepressant sertaline for 20 days. In our study, the global QTc interval (12 leads) was determined automatically by applying ECG device of the producer and type "Schiller Cardiovit AT-1"which uses "SCHILLER ECG Measurement and Interpretation Software for Children and Adults ECGs". Measured empirical values of data were statistically processed in SPSS 16.0 programme package for Windows. Methods of descriptive statistics and methods of statistic testing of hypotheses were used. Results : In our study, in spite of the vulnerability of patients due to the heart damage and the lyver dysfunction arising from alcohol consumption, as well as altered patients drugs metabolism, no elongation of QTc interval resulting from the application of sertaline was established (p=0.735). The average prolongation of QTc interval of 1.633 ms was observed (95% CI =8.005 ms, 11.270 ms). Conclusion :Our study does not indicate that the antidepressant drug sertaline has a statistically significant effect on the prolongation of the QT interval of depressed patients with alcohol dependence.
精神病学中的抑郁症涵盖了精神病理学的一个大领域，它是现代医学中最复杂的问题之一，对个人和整个社会的健康有着广泛的影响。抑郁症也是酒精成瘾的常见伴侣。本研究旨在探讨抗抑郁药物舍他林对酒精依赖抑郁症患者QT间期长度的影响。患者和方法:本研究纳入男性(18岁以上)酒精成瘾患者，在入院之初，根据DSM-IV(精神障碍诊断与统计手册)标准和阳性的汉密尔顿抑郁评定量表(HRSD)诊断为抑郁症，即抑郁症。该研究纳入了49名服用抗抑郁药舍他林20天的患者。在我们的研究中，整体QTc间隔(12导联)是由生产商的ECG设备自动确定的，型号为“席勒心血管AT-1”，该设备使用“席勒儿童和成人ECG测量和解释软件”。实测数据的经验值用SPSS 16.0程序包进行统计处理。采用描述性统计方法和假设检验的统计方法。结果:在我们的研究中，尽管存在患者因饮酒引起的心脏损伤和肝功能障碍的易感，以及患者药物代谢的改变，但没有发现舍他林的应用导致QTc间期延长(p=0.735)。QTc间隔平均延长1.633 ms (95% CI =8.005 ms, 11.270 ms)。结论:本研究未发现抗抑郁药物舍他林对酒精依赖抑郁症患者QT间期延长有统计学意义。
{"title":"ANALYSIS OF EFFECT OF THE ANTIDEPRESSANT SERTALINE ON THE LEGHT OF QT INTERVAL IN PATIENTS WITH DEPRESSION AND ALCOHOL DEPENDENCE","authors":"S. Stojanovic, Zlatan Stojanović, Gordana Macanović, N. Banjac, Želimir Erić","doi":"10.24125/SANAMED.V14I1.301","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.301","url":null,"abstract":"Introduction and Aim: Depression in psychiatry covers a large area of mental pathology and it is one of the most complex problems of modern medicine with broad implications for the health of the individual and the society as a whole. Depression is also a frequent companion of alcohol addiction. The aim of this study was to investigate the effect of the antidepressant drug sertaline on the lenght of QT interval in depressed patients with alcohol dependence. Patients and methods : This research included male patients (older than 18 years of age) suffering from alcohol addiction, who were also diagnosed with depression, that is, depressive disorder,at the beginnig of hospitalisation, on the basis of DSM-IV (Diagnostic and statistical manual of mental disorders) criterion and positive Hamilton Rating Scale for Depression (HRSD). The study included 49 patients treated wit antidepressant sertaline for 20 days. In our study, the global QTc interval (12 leads) was determined automatically by applying ECG device of the producer and type \"Schiller Cardiovit AT-1\"which uses \"SCHILLER ECG Measurement and Interpretation Software for Children and Adults ECGs\". Measured empirical values of data were statistically processed in SPSS 16.0 programme package for Windows. Methods of descriptive statistics and methods of statistic testing of hypotheses were used. Results : In our study, in spite of the vulnerability of patients due to the heart damage and the lyver dysfunction arising from alcohol consumption, as well as altered patients drugs metabolism, no elongation of QTc interval resulting from the application of sertaline was established (p=0.735). The average prolongation of QTc interval of 1.633 ms was observed (95% CI =8.005 ms, 11.270 ms). Conclusion :Our study does not indicate that the antidepressant drug sertaline has a statistically significant effect on the prolongation of the QT interval of depressed patients with alcohol dependence.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46744005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.323
Mersudin Mulić, B. Lazovic, Džemail Detanac, Dzenana A. Detanac, R. Milić, V. Žugić
Introduction: Localized interlobar effusions in congestive heart failure (phantom or vanishing lung tumor/s) are infrequent, but widely recognized entities. Case report: A 80-years-old woman affected by progressive dyspnea over the previous three months, with productive cough. She was treated hypertension and had a pace maker implanted due to bradycardia. Chest X ray has shown right side pneumonia with high positive inflammatory markers. After resolution of pneumonia, phantom tumor of the lung was revealed, which disappear with intensive loop diuretics. Conclusions: The diagnosis of the phantom tumor ought to be pondered as a possibility in any patient with congestive heart failure and lung mass. The patient at hand featured no prior history of congestive heart failure, hence indicating that phantom tumor may occur in non-chronic heart failure patients. Albeid the reliable diagnosis of the phantom tumor through the utilization of imaging modalities in patients without congestive heart failure can be rather challenging, such possibility must be considered in a patient with a lung mass in the major fissure of the lungs. Due to accelerated expansion of the geriatric population and subsequent spread of the congestive heart failure, a rise in the incidence of vanishing tumors of the lung may be anticipated.
{"title":"PHANTOM TUMOR OF THE LUNG IN PATIENT WITH PNEUMONIA","authors":"Mersudin Mulić, B. Lazovic, Džemail Detanac, Dzenana A. Detanac, R. Milić, V. Žugić","doi":"10.24125/SANAMED.V14I1.323","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.323","url":null,"abstract":"Introduction: Localized interlobar effusions in congestive heart failure (phantom or vanishing lung tumor/s) are infrequent, but widely recognized entities. Case report: A 80-years-old woman affected by progressive dyspnea over the previous three months, with productive cough. She was treated hypertension and had a pace maker implanted due to bradycardia. Chest X ray has shown right side pneumonia with high positive inflammatory markers. After resolution of pneumonia, phantom tumor of the lung was revealed, which disappear with intensive loop diuretics. Conclusions: The diagnosis of the phantom tumor ought to be pondered as a possibility in any patient with congestive heart failure and lung mass. The patient at hand featured no prior history of congestive heart failure, hence indicating that phantom tumor may occur in non-chronic heart failure patients. Albeid the reliable diagnosis of the phantom tumor through the utilization of imaging modalities in patients without congestive heart failure can be rather challenging, such possibility must be considered in a patient with a lung mass in the major fissure of the lungs. Due to accelerated expansion of the geriatric population and subsequent spread of the congestive heart failure, a rise in the incidence of vanishing tumors of the lung may be anticipated.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47459981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.322
D. Sengul
Objectives: Gastric intestinal metaplasia have traditionally been associated with gastric adenocarcinoma. Gastric intestinal metaplasia is usually related to the Helicobacter pylori infection, older ages, smoking history, consumption of strong spicy foods, socioeconomic status and presence of IL10-592 C/A. The purpose of the present research study was to evaluate the simple laboratory parameters in subjects with gastric intestinal metaplasia Findings: From May 2018 and October 2018, a total of 541, 281 male and 260 female, consecutive cases with gastric intestinal metaplasia with the mean age of 58.5±15 years had been enrolled retrospectively with exclusion of the cases with a severe underlying disease, including a gastric cancer and gastric resection. The gastroscopy with the antral biopsy had been performed for all the cases and the biopsy samples had been evaluated for the presence of gastric intestinal metaplasia by Hematoxylin and Eosin and Helicobacter pylori status by Giemsa.The chi-squared test and independent t test were used for comparison. The mean serum urea level detected as 34.2.±16.1 mg/dL in the gastric intestinal metaplasia and 31.2±13.1 mg/dL in the control (95% CI from 32,3 to 34,6; p =0.013), while the mean serum creatinin level 0.84±0.28 mg/dL in the gastric intestinal metaplasia and 0.80±0.26 mg/dL in the control (95% CI from 0,80 to 0,85; p =0.042). Gastric intestinal metaplasia was detected mostly in elderly and male, regarding the multiple logistic regression ( p <0.001). Conclusion: The serum urea and creatinin levels may serve as a simple clinical tool to predict the cases patients at risk for gastric intestinal metaplasia.
{"title":"IS PREDICTION OF RENAL FAILURE WITH ITS INDICES FEASIBLE WITH PRESENCE OF HISTOPATHOLOGIC EVIDENCE FOR GASTRIC INTESTINAL METAPLASIA ?","authors":"D. Sengul","doi":"10.24125/SANAMED.V14I1.322","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.322","url":null,"abstract":"Objectives: Gastric intestinal metaplasia have traditionally been associated with gastric adenocarcinoma. Gastric intestinal metaplasia is usually related to the Helicobacter pylori infection, older ages, smoking history, consumption of strong spicy foods, socioeconomic status and presence of IL10-592 C/A. The purpose of the present research study was to evaluate the simple laboratory parameters in subjects with gastric intestinal metaplasia Findings: From May 2018 and October 2018, a total of 541, 281 male and 260 female, consecutive cases with gastric intestinal metaplasia with the mean age of 58.5±15 years had been enrolled retrospectively with exclusion of the cases with a severe underlying disease, including a gastric cancer and gastric resection. The gastroscopy with the antral biopsy had been performed for all the cases and the biopsy samples had been evaluated for the presence of gastric intestinal metaplasia by Hematoxylin and Eosin and Helicobacter pylori status by Giemsa.The chi-squared test and independent t test were used for comparison. The mean serum urea level detected as 34.2.±16.1 mg/dL in the gastric intestinal metaplasia and 31.2±13.1 mg/dL in the control (95% CI from 32,3 to 34,6; p =0.013), while the mean serum creatinin level 0.84±0.28 mg/dL in the gastric intestinal metaplasia and 0.80±0.26 mg/dL in the control (95% CI from 0,80 to 0,85; p =0.042). Gastric intestinal metaplasia was detected mostly in elderly and male, regarding the multiple logistic regression ( p <0.001). Conclusion: The serum urea and creatinin levels may serve as a simple clinical tool to predict the cases patients at risk for gastric intestinal metaplasia.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44888104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.277
Kusuayi Mabele Godefroid, Constant Nkiama Ekisawa, Jolie Bongo Nzeloka, C. Delecluse, F. L. Bompeka
Objective: To determine the prevalence of overweight and obesity in the workplace. Methods: We conducted a cross-sectional study with 210 workers of which 119 male (56.7%) and 91 female (43.3%) selected in a simple random manner in a company in the city of Kinshasa province between November 2013 to January 2014. Overweight was determined by workers with a body mass index between 25 and 29.9 kg / m 2 and obesity by those with a body mass index ≥ 30 kg / m 2 . Results: This study found a prevalence of 23.8% of overweight workers and 48.1% of workers suffering from obesity with predominance in women (65.5% in men vs. 80.2% in women, p <0.014). The frequency of risk factors associated with obesity increased with the increase in weight status of BMI (p <0.001). Conclusion: Obesity is a common pathology in the workplace and hypertension is the main modifiable risk factor. Sedentarity is the main determinant of overweight and obesity. Obesity is a public health problem in the workplace in the city of Kinshasa because of the command and collaboration frameworks are most affected.
目的:了解工作场所超重和肥胖的患病率。方法:2013年11月至2014年1月，我们在金沙萨省的一家公司以简单随机的方式选取了210名工人进行横断面研究，其中男性119人(56.7%)，女性91人(43.3%)。体重指数在25 ~ 29.9 kg / m2之间的工人确定超重，体重指数≥30 kg / m2的工人确定肥胖。结果:本研究发现，23.8%的工人超重，48.1%的工人肥胖，以女性为主(男性65.5%比女性80.2%，p <0.014)。肥胖相关危险因素的出现频率随着体重指数的增加而增加(p <0.001)。结论:肥胖是工作场所的常见病理，高血压是主要的可改变危险因素。久坐不动是超重和肥胖的主要决定因素。肥胖是金沙萨市工作场所的一个公共卫生问题，因为指挥和协作框架受到的影响最大。
{"title":"EPIDEMIOLOGY OF OVERWEIGHT AND OBESITY OF TRAITORS OF THE MULTIMODAL FREIGHT MANAGEMENT OFFICE OF THE CITY PROVINCE OF KINSHASA","authors":"Kusuayi Mabele Godefroid, Constant Nkiama Ekisawa, Jolie Bongo Nzeloka, C. Delecluse, F. L. Bompeka","doi":"10.24125/SANAMED.V14I1.277","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.277","url":null,"abstract":"Objective: To determine the prevalence of overweight and obesity in the workplace. Methods: We conducted a cross-sectional study with 210 workers of which 119 male (56.7%) and 91 female (43.3%) selected in a simple random manner in a company in the city of Kinshasa province between November 2013 to January 2014. Overweight was determined by workers with a body mass index between 25 and 29.9 kg / m 2 and obesity by those with a body mass index ≥ 30 kg / m 2 . Results: This study found a prevalence of 23.8% of overweight workers and 48.1% of workers suffering from obesity with predominance in women (65.5% in men vs. 80.2% in women, p <0.014). The frequency of risk factors associated with obesity increased with the increase in weight status of BMI (p <0.001). Conclusion: Obesity is a common pathology in the workplace and hypertension is the main modifiable risk factor. Sedentarity is the main determinant of overweight and obesity. Obesity is a public health problem in the workplace in the city of Kinshasa because of the command and collaboration frameworks are most affected.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44831982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.293
M. Bosnjak, Milota Dobovski-Poslon, Željko Bibić, Kristina Bošnjak
Stress represents a negative life experience, closely followed by physiological, cognitive, emotional, and behavioral changes that focus on changing the event or adapting to its effects. Any situation or occurrence that requires adaptation can be experienced as a stress, even positive situations and circumstances may be stressful, whether they come from the outside world, or the sources of stress is internal. While acute stress does not necessarily have a negative effect, if it lasts for a long time, or is frequently repeated, it becomes chronic, and can cause various serious disorders. During chronic stress, there is an exhaustion of the body's capacity for an adequate reaction, which can lead to long-lasting immunological dysfunction, which significantly impairs health and quality of life. According to the WHO (2017), stress is one of the causes of even 60% known diseases, and in a number of mental disorders a direct connection with stress has been reported: in acute stress reactions, "posttraumatic stress disorder", adjustment disorders and other reactions to severe stress. In addition, in all categories of mental disorders (ICD-10), the stressful situation or event plays a significant role in occurrence of the symptoms. A particular category of stress-related disorders are psychosomatic disorders. These are functional disorders in which there is no pathoanatomic substrate. In contrast to these, psychosomatic diseases are the type of illness in which there are structural changes of tissues and organs, the etiology of which is based on chronic stress, in addition to a number of other factors (Adamovic, 1983) and which occur when there is a biological predisposition. The paper presents the mechanism of development of these diseases and some of the ways of coping with stress. According to the DSM-V, psychosomatic diseases are divided into skin diseases, gastrointestinal diseases, respiratory diseases, heart and blood vessel diseases, disorders of endocrine glands, rheumatoid diseases, gynecological diseases and others. In order to overcome stress and preserve health, psychological strategies for coping with stress play an important role. Multiple strategies are used, which include various stress control techniques: relaxation techniques, meditation methods, and assertive training, biofeedback and stress inoculation techniques. Successful mastering of coping stressful situations, constructive problem solving in life crisis, relaxation techniques and contributions to better adaptation to unexpected changes in life are of key importance for both mental and physical health.
{"title":"THE INFLUENCE OF CHRONIC STRESS ON HEALTH AND COPING MECHANISMS","authors":"M. Bosnjak, Milota Dobovski-Poslon, Željko Bibić, Kristina Bošnjak","doi":"10.24125/SANAMED.V14I1.293","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.293","url":null,"abstract":"Stress represents a negative life experience, closely followed by physiological, cognitive, emotional, and behavioral changes that focus on changing the event or adapting to its effects. Any situation or occurrence that requires adaptation can be experienced as a stress, even positive situations and circumstances may be stressful, whether they come from the outside world, or the sources of stress is internal. While acute stress does not necessarily have a negative effect, if it lasts for a long time, or is frequently repeated, it becomes chronic, and can cause various serious disorders. During chronic stress, there is an exhaustion of the body's capacity for an adequate reaction, which can lead to long-lasting immunological dysfunction, which significantly impairs health and quality of life. According to the WHO (2017), stress is one of the causes of even 60% known diseases, and in a number of mental disorders a direct connection with stress has been reported: in acute stress reactions, \"posttraumatic stress disorder\", adjustment disorders and other reactions to severe stress. In addition, in all categories of mental disorders (ICD-10), the stressful situation or event plays a significant role in occurrence of the symptoms. A particular category of stress-related disorders are psychosomatic disorders. These are functional disorders in which there is no pathoanatomic substrate. In contrast to these, psychosomatic diseases are the type of illness in which there are structural changes of tissues and organs, the etiology of which is based on chronic stress, in addition to a number of other factors (Adamovic, 1983) and which occur when there is a biological predisposition. The paper presents the mechanism of development of these diseases and some of the ways of coping with stress. According to the DSM-V, psychosomatic diseases are divided into skin diseases, gastrointestinal diseases, respiratory diseases, heart and blood vessel diseases, disorders of endocrine glands, rheumatoid diseases, gynecological diseases and others. In order to overcome stress and preserve health, psychological strategies for coping with stress play an important role. Multiple strategies are used, which include various stress control techniques: relaxation techniques, meditation methods, and assertive training, biofeedback and stress inoculation techniques. Successful mastering of coping stressful situations, constructive problem solving in life crisis, relaxation techniques and contributions to better adaptation to unexpected changes in life are of key importance for both mental and physical health.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45258898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.303
M. Izzuddin, A. Ishak, N. Basiron
Congenital midline upper lip sinuses or fistulas are exceptionally uncommon condition following abnormal fusion of embryologic structures. Here, we report a case of congenital upper lip sinus type I presented as upper vestibular fold abscess in a seven year old boy.
{"title":"LIP PITS ABSCESS: ISOLATED CONGENITAL MIDLINE UPPER LIP SINUS","authors":"M. Izzuddin, A. Ishak, N. Basiron","doi":"10.24125/SANAMED.V14I1.303","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.303","url":null,"abstract":"Congenital midline upper lip sinuses or fistulas are exceptionally uncommon condition following abnormal fusion of embryologic structures. Here, we report a case of congenital upper lip sinus type I presented as upper vestibular fold abscess in a seven year old boy.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44440583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.24125/SANAMED.V14I1.300
O. Kardas, Burcu Kardaş
Oxybutynin is one of the most commonly prescribed drugs in overactive bladder treatment. Because of its lipophilic structure, it crosses the blood-brain barrier and causes cognitive side effects in the central nervous system. Abuse of the drug is due to its hallucinogenic effect. In terms of substance use disorder, adolescents are one of the groups at risk. In addition to well-known addictive substances, drugs which have sedative, anticholinergic-antimuscarinic, stimulant properties and prescribed for any treatment also can be abused in adolescents with substance abuse. In this article, it is aimed to raise awareness of physicians and health workers about oxybutynin abuse because of the pharmacodynamic characteristics of the drug and its effects on the central nervous system. The health professionals should therefore prescribe this drug with more attention and follow-up those patients.
{"title":"THE OXYBUTYNIN ABUSE IN ADOLESCENT CASE","authors":"O. Kardas, Burcu Kardaş","doi":"10.24125/SANAMED.V14I1.300","DOIUrl":"https://doi.org/10.24125/SANAMED.V14I1.300","url":null,"abstract":"Oxybutynin is one of the most commonly prescribed drugs in overactive bladder treatment. Because of its lipophilic structure, it crosses the blood-brain barrier and causes cognitive side effects in the central nervous system. Abuse of the drug is due to its hallucinogenic effect. In terms of substance use disorder, adolescents are one of the groups at risk. In addition to well-known addictive substances, drugs which have sedative, anticholinergic-antimuscarinic, stimulant properties and prescribed for any treatment also can be abused in adolescents with substance abuse. In this article, it is aimed to raise awareness of physicians and health workers about oxybutynin abuse because of the pharmacodynamic characteristics of the drug and its effects on the central nervous system. The health professionals should therefore prescribe this drug with more attention and follow-up those patients.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44401285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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