Objective: PCOS, which is known as a symptom complex including menstrual dysfunction (OD) and or hirsutism/androgen excess (HA), and/or polycystic ovaries (PCOM), induces women's health damage beyond this classical criteria. Subphenotypes of PCOS have different clinical properties and criteria, and the metabolical differences between these phenotypes have not been elucidated properly. Therefore, we aimed to investigate the metabolic and endocrinological differences between these sub-phenotypes. Materials and Methods: 63 patients with PCOS followed by Istanbul Research and Education Hospital Endocrinology and Metabolism Department were included in the study. Patients were classified into subgroups according to phenotypes. The phenotype groups were compared according to blood glucose, lipid parameters, and serum hormone levels. MetS ratios between groups were also compared. Results: Androgen excess/hirsutism was the most prominent character with a 95.2% (n=60) rate in this study group, and ovulatory dysfunction was the least prominent one. (n=43, 68.2%) PCOM has been detected in 50 patients (80.8%). Patients were grouped according to PCOS phenotypes. Phenotype C was the most common type, and about 65% of the patients were in this group. Triglyceride levels were statistically significantly higher in the Phenotype A group than in the Phenotype B group (p=0.03). MetS was the highest in the Phenotype A group (45.4%) and the lowest in the Phenotype C group (34.7%). Conclusions: Phenotype C has the highest prevalence in Turkish patients with PCOS, MetS was the highest in Phenotype A, and TG and LDL cholesterol levels were higher in Phenotype A. More studies are needed to explain these differences and their lifetime consequences.
{"title":"Phenotypes of polycystic ovary syndrome and accompanying hormonal disturbances","authors":"Karatas Savas, Hacıoğlu Burcu, Kalaycı Gökhan","doi":"10.5937/sanamed0-40164","DOIUrl":"https://doi.org/10.5937/sanamed0-40164","url":null,"abstract":"Objective: PCOS, which is known as a symptom complex including menstrual dysfunction (OD) and or hirsutism/androgen excess (HA), and/or polycystic ovaries (PCOM), induces women's health damage beyond this classical criteria. Subphenotypes of PCOS have different clinical properties and criteria, and the metabolical differences between these phenotypes have not been elucidated properly. Therefore, we aimed to investigate the metabolic and endocrinological differences between these sub-phenotypes. Materials and Methods: 63 patients with PCOS followed by Istanbul Research and Education Hospital Endocrinology and Metabolism Department were included in the study. Patients were classified into subgroups according to phenotypes. The phenotype groups were compared according to blood glucose, lipid parameters, and serum hormone levels. MetS ratios between groups were also compared. Results: Androgen excess/hirsutism was the most prominent character with a 95.2% (n=60) rate in this study group, and ovulatory dysfunction was the least prominent one. (n=43, 68.2%) PCOM has been detected in 50 patients (80.8%). Patients were grouped according to PCOS phenotypes. Phenotype C was the most common type, and about 65% of the patients were in this group. Triglyceride levels were statistically significantly higher in the Phenotype A group than in the Phenotype B group (p=0.03). MetS was the highest in the Phenotype A group (45.4%) and the lowest in the Phenotype C group (34.7%). Conclusions: Phenotype C has the highest prevalence in Turkish patients with PCOS, MetS was the highest in Phenotype A, and TG and LDL cholesterol levels were higher in Phenotype A. More studies are needed to explain these differences and their lifetime consequences.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71045616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Dugalić, J. Todorović, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, I. Pantić, M. Perović, M. Gojnić
Diabetes mellitus is a metabolic disorder that can occur before pregnancy, be detected during pregnancy, or develop during pregnancy. Therapeutic modalities available today significantly facilitate glycoregulation during pregnancy and childbirth. This review presents different insulin regimens, as well as the advantages and disadvantages of oral antidiabetic agents use with a special focus on hypoglycemia. The importance of maintaining optimal glycemic levels and educating patients in blood glucose self-measurement is explained.
{"title":"Theoretical basis of perinatology therapy in pregnant women with diabetes mellitus","authors":"S. Dugalić, J. Todorović, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, I. Pantić, M. Perović, M. Gojnić","doi":"10.5937/sanamed0-40167","DOIUrl":"https://doi.org/10.5937/sanamed0-40167","url":null,"abstract":"Diabetes mellitus is a metabolic disorder that can occur before pregnancy, be detected during pregnancy, or develop during pregnancy. Therapeutic modalities available today significantly facilitate glycoregulation during pregnancy and childbirth. This review presents different insulin regimens, as well as the advantages and disadvantages of oral antidiabetic agents use with a special focus on hypoglycemia. The importance of maintaining optimal glycemic levels and educating patients in blood glucose self-measurement is explained.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71045669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Jordanova, P. Hentova-Senćanić, I. Marjanović, Ivan Senčanin, Ivana Stefanović, M. Baralić
Introduction: The study aimed to assert the relationship between central corneal thickness (CCT) and intraocular pressure (IOP) measured by: Goldmann applanation tonometry (GAT) and Dynamic contour tonometry (DCT). Materials and Methods: The study included 150 patients with a mean age of 59.39 ± 13.12 years. Patients were divided into three groups: 50 primary open-angle glaucoma (POAG) patients, 50 ocular hypertension (OHT) patients, and 50 normal tension glaucoma (NTG) patients. IOP was determined using GAT and DCT. CCT was measured by ultrasound pachymetry. Results: IOP measured with DCT was higher than IOP measured with GAT (19.80 ± 3.67 mmHg vs 17.71 ± 3.35 mmHg). A significant positive association between IOP measured with GAT and IOP measured with DCT was found in all patients (r = 0.867, p < 0.01). A significantly positive association between IOP measured with GAT and IOP measured with DCT in POAG (r = 0.855, p <0.01), OHT (r = 0.826, p < 0.01), and NTG patients (r = 0.832, p < 0.01) were found. A significant positive correlation between CCT and IOP measured with GAT (r = 0.198, p < 0.01), as well as a significant positive correlation between CCT and IOP measured with DCT was found (r = 0.198, p < 0.01) in all patients. There was no correlation between CCT and IOP measured neither with GAT nor with DCT separately in three patient groups (p > 0.05). Conclusion: CCT-influenced IOP was measured by both methods, GAT and DCT. DCT can not replace GAT, but it is very useful, especially in cases where errors are in the IOP GAT measurement.
前言:本研究旨在确定角膜中央厚度(CCT)与眼压(IOP)之间的关系:Goldmann压平眼压(GAT)和动态等高线眼压(DCT)测量。材料与方法:纳入150例患者，平均年龄59.39±13.12岁。将患者分为3组:50例原发性开角型青光眼(POAG)、50例高眼压(OHT)和50例正常张力型青光眼(NTG)。用GAT和DCT测定眼压。超声测厚法测定CCT。结果:DCT测量的IOP高于GAT测量的IOP(19.80±3.67 mmHg vs 17.71±3.35 mmHg)。GAT测量IOP与DCT测量IOP在所有患者中均有显著正相关(r = 0.867, p < 0.01)。POAG患者GAT测IOP与DCT测IOP呈正相关(r = 0.855, p 0.05)。结论:采用GAT和DCT两种方法测量cct对IOP的影响。DCT不能代替GAT，但它非常有用，特别是在IOP GAT测量存在误差的情况下。
{"title":"The cornea and methods for measuring intraocular pressure","authors":"E. Jordanova, P. Hentova-Senćanić, I. Marjanović, Ivan Senčanin, Ivana Stefanović, M. Baralić","doi":"10.5937/sanamed0-41040","DOIUrl":"https://doi.org/10.5937/sanamed0-41040","url":null,"abstract":"Introduction: The study aimed to assert the relationship between central corneal thickness (CCT) and intraocular pressure (IOP) measured by: Goldmann applanation tonometry (GAT) and Dynamic contour tonometry (DCT). Materials and Methods: The study included 150 patients with a mean age of 59.39 ± 13.12 years. Patients were divided into three groups: 50 primary open-angle glaucoma (POAG) patients, 50 ocular hypertension (OHT) patients, and 50 normal tension glaucoma (NTG) patients. IOP was determined using GAT and DCT. CCT was measured by ultrasound pachymetry. Results: IOP measured with DCT was higher than IOP measured with GAT (19.80 ± 3.67 mmHg vs 17.71 ± 3.35 mmHg). A significant positive association between IOP measured with GAT and IOP measured with DCT was found in all patients (r = 0.867, p < 0.01). A significantly positive association between IOP measured with GAT and IOP measured with DCT in POAG (r = 0.855, p <0.01), OHT (r = 0.826, p < 0.01), and NTG patients (r = 0.832, p < 0.01) were found. A significant positive correlation between CCT and IOP measured with GAT (r = 0.198, p < 0.01), as well as a significant positive correlation between CCT and IOP measured with DCT was found (r = 0.198, p < 0.01) in all patients. There was no correlation between CCT and IOP measured neither with GAT nor with DCT separately in three patient groups (p > 0.05). Conclusion: CCT-influenced IOP was measured by both methods, GAT and DCT. DCT can not replace GAT, but it is very useful, especially in cases where errors are in the IOP GAT measurement.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mirjana Petrović-Lazić, S. Babac, Ivana Ilić-Savić
Swallowing disorders can occur at any age, although they occur more often in old age when the physiology of swallowing changes due to aging. Oropharyngeal dysphagia is a very common clinical condition affecting 13% of the total population over 65 years of age and 51% of institutionalized older people. Given that oropharyngeal dysphagia can lead to increased morbidity and mortality in the elderly, it is necessary to prevent the occurrence of dysphagia in this population group as much as possible. In relation to this, the paper aims to provide insight into contemporary research into the etiology, pathophysiology, and symptomatology of oropharyngeal dysphagia in the elderly. In this review study, the electronic databases of Google Scholar Advanced Search and the Consortium of Serbian Libraries for Unified Procurement - KoBSON were searched. The following keywords and phrases were used in the search: swallowing, dysphagia, oropharyngeal dysphagia, aging, age and dysphagia, etiology of oropharyngeal dysphagia, the clinical picture of oropharyngeal dysphagia, pathophysiology of oropharyngeal dysphagia. This systematic review and meta-analysis of papers showed significant progress in the effective diagnostic approach of oropharyngeal dysphagia during the last years but also a significant lack of knowledge about adequate modifications of drugs applied during the treatment of patients with dysphagia. A good understanding of the etiology, pathophysiology, and symptomatology of oropharyngeal dysphagia would eliminate the harmful effects of pharmacological substances on the function of swallowing, given that the elderly, on the advice of a doctor, use them daily.
{"title":"Oropharyngeal dysphagia in elderly persons: Etiology, pathophysiology and symptomatology","authors":"Mirjana Petrović-Lazić, S. Babac, Ivana Ilić-Savić","doi":"10.5937/sanamed0-40913","DOIUrl":"https://doi.org/10.5937/sanamed0-40913","url":null,"abstract":"Swallowing disorders can occur at any age, although they occur more often in old age when the physiology of swallowing changes due to aging. Oropharyngeal dysphagia is a very common clinical condition affecting 13% of the total population over 65 years of age and 51% of institutionalized older people. Given that oropharyngeal dysphagia can lead to increased morbidity and mortality in the elderly, it is necessary to prevent the occurrence of dysphagia in this population group as much as possible. In relation to this, the paper aims to provide insight into contemporary research into the etiology, pathophysiology, and symptomatology of oropharyngeal dysphagia in the elderly. In this review study, the electronic databases of Google Scholar Advanced Search and the Consortium of Serbian Libraries for Unified Procurement - KoBSON were searched. The following keywords and phrases were used in the search: swallowing, dysphagia, oropharyngeal dysphagia, aging, age and dysphagia, etiology of oropharyngeal dysphagia, the clinical picture of oropharyngeal dysphagia, pathophysiology of oropharyngeal dysphagia. This systematic review and meta-analysis of papers showed significant progress in the effective diagnostic approach of oropharyngeal dysphagia during the last years but also a significant lack of knowledge about adequate modifications of drugs applied during the treatment of patients with dysphagia. A good understanding of the etiology, pathophysiology, and symptomatology of oropharyngeal dysphagia would eliminate the harmful effects of pharmacological substances on the function of swallowing, given that the elderly, on the advice of a doctor, use them daily.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Tosun, N. Akçay, Emin Menentoğlu, E. Şevketoğlu, Ozgul Salihoğlu
Introduction: Hyperammonemia occurs as a result of the inability to convert ammonia, a metabolic toxin, into urea due to a block in the urea cycle, and there resulting neurotoxicity is responsible for the pathogenesis. Case Presentation: Our patient was 7 days old when followed up in an external center for 3 days with a preliminary diagnosis of neonatal sepsis. Lethargy, vomiting, tachypnea, and convulsions, which are frequently seen in the first neonatal forms of urea cycle disorders, were also present in our patient. He was referred to us as a result of high ammonia levels when he was examined in terms of congenital metabolic diseases. He was intubated due to the rapid development of respiratory failure. When he was admitted to our intensive care unit with hyperammonemia, light reflex could not be obtained, and widespread cutis marmaratus was developed. Continuous renal replacement therapy was started in our patient and administered intermittently for 120 hours. The glucose infusion rate was followed by high fluid. When it orally tolerated, it is supported with sodium benzoate and sodium stearyl fumarate to reduce ammonia. Nutrition was limited to protein with Basic P. Conclusion: After staying in the intensive care unit for 30 days, our patient was discharged with the recommendation of outpatient follow-up by the pediatric metabolism physician. When our patient came for his check up after two months, there was no nystagmus and no seizures.
{"title":"Newborn treated with continuous renal replacement therapy for citrulinemia-type 1","authors":"D. Tosun, N. Akçay, Emin Menentoğlu, E. Şevketoğlu, Ozgul Salihoğlu","doi":"10.5937/sanamed0-40473","DOIUrl":"https://doi.org/10.5937/sanamed0-40473","url":null,"abstract":"Introduction: Hyperammonemia occurs as a result of the inability to convert ammonia, a metabolic toxin, into urea due to a block in the urea cycle, and there resulting neurotoxicity is responsible for the pathogenesis. Case Presentation: Our patient was 7 days old when followed up in an external center for 3 days with a preliminary diagnosis of neonatal sepsis. Lethargy, vomiting, tachypnea, and convulsions, which are frequently seen in the first neonatal forms of urea cycle disorders, were also present in our patient. He was referred to us as a result of high ammonia levels when he was examined in terms of congenital metabolic diseases. He was intubated due to the rapid development of respiratory failure. When he was admitted to our intensive care unit with hyperammonemia, light reflex could not be obtained, and widespread cutis marmaratus was developed. Continuous renal replacement therapy was started in our patient and administered intermittently for 120 hours. The glucose infusion rate was followed by high fluid. When it orally tolerated, it is supported with sodium benzoate and sodium stearyl fumarate to reduce ammonia. Nutrition was limited to protein with Basic P. Conclusion: After staying in the intensive care unit for 30 days, our patient was discharged with the recommendation of outpatient follow-up by the pediatric metabolism physician. When our patient came for his check up after two months, there was no nystagmus and no seizures.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aslan Nuray, Necip Gokhan, Durmus Ensar, Guneysu Fatih, Yurumez Yusuf
Background: Since its emergence, coronavirus disease 2019 (COVID-19) has been a challenge to manage and has resulted in high mortality rates. Aim: This study aimed to reveal the differences in the parameters at the time during the first admission, according to age groups in patients who applied due to Covid-19 and died in the hospital. Methods: This was a retrospective, cross-sectional, and descriptive study covering the period from March 16 to May 9, 2021. The study population (1169 patients) included patients with COVID-19 who presented to the emergency department and died in the hospital. The data required for this study were obtained from the electronic medical records of the patients in the information system of our hospital. The patients were divided into three groups and analyzed. Results: It was determined that the highest mortality rate was 547 (46.8%) in the 65-80 age group. In terms of comorbidities, there was a statistically significant difference between the three groups only in the incidence of asthma (p = 0.037). When the laboratory parameters and patient age groups were compared; a statistically significant difference was found in D-dimer, ferritin, WBC, platelet, and neutrophil values (respectively: p=0.001, p=0.020, p=0.005, p=0.029, p=0.037). Conclusion: The highest death rate in Covid 19 patients is seen in the 65-80 age group. In patients over 80 years of age, the presence of asthma and the increase in D-dimer and ferritin levels among laboratory parameters can be used to predict mortality.
{"title":"Differences in inflammatory markers in COVID-19 mortality in patients aged 18-65, 65-80 and 80 years and older","authors":"Aslan Nuray, Necip Gokhan, Durmus Ensar, Guneysu Fatih, Yurumez Yusuf","doi":"10.5937/sanamed0-40546","DOIUrl":"https://doi.org/10.5937/sanamed0-40546","url":null,"abstract":"Background: Since its emergence, coronavirus disease 2019 (COVID-19) has been a challenge to manage and has resulted in high mortality rates. Aim: This study aimed to reveal the differences in the parameters at the time during the first admission, according to age groups in patients who applied due to Covid-19 and died in the hospital. Methods: This was a retrospective, cross-sectional, and descriptive study covering the period from March 16 to May 9, 2021. The study population (1169 patients) included patients with COVID-19 who presented to the emergency department and died in the hospital. The data required for this study were obtained from the electronic medical records of the patients in the information system of our hospital. The patients were divided into three groups and analyzed. Results: It was determined that the highest mortality rate was 547 (46.8%) in the 65-80 age group. In terms of comorbidities, there was a statistically significant difference between the three groups only in the incidence of asthma (p = 0.037). When the laboratory parameters and patient age groups were compared; a statistically significant difference was found in D-dimer, ferritin, WBC, platelet, and neutrophil values (respectively: p=0.001, p=0.020, p=0.005, p=0.029, p=0.037). Conclusion: The highest death rate in Covid 19 patients is seen in the 65-80 age group. In patients over 80 years of age, the presence of asthma and the increase in D-dimer and ferritin levels among laboratory parameters can be used to predict mortality.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The principal role of biochemical laboratories is responsibility for reliable, reproducible, accurate, timely, and accurately interpreted analysis results that help in making clinical decisions, while ensuring the desired clinical outcomes. To achieve this goal, the laboratory should introduce and maintain quality control in all phases of work. The importance of applying the Six SIGMA quality model has been analyzed in a large number of scientific studies. The purpose of this review is to highlight the importance of using six SIGMA metrics in biochemical laboratories and the current application of six SIGMA metrics in all laboratory work procedures. It has been shown that the six SIGMA model can be very useful in improving all phases of laboratory work, as well as that a detailed assessment of all procedures of the phases of work and improvement of the laboratory's quality control system is crucial for the laboratory to have the highest level of six SIGMA. Clinical laboratories should use SIGMA metrics to monitor their performance, as it makes it easier to identify gaps in their performance, thereby improving their efficiency and patient safety. Medical laboratory quality managers should provide a systematic methodology for analyzing and correcting quality assurance systems to achieve Six SIGMA quality-level standards.
{"title":"\"Six Sigma\" standard as a level of quality of biochemical laboratories","authors":"Aleksandra Pašić, Emir Šeherčehajić","doi":"10.5937/sanamed0-40408","DOIUrl":"https://doi.org/10.5937/sanamed0-40408","url":null,"abstract":"The principal role of biochemical laboratories is responsibility for reliable, reproducible, accurate, timely, and accurately interpreted analysis results that help in making clinical decisions, while ensuring the desired clinical outcomes. To achieve this goal, the laboratory should introduce and maintain quality control in all phases of work. The importance of applying the Six SIGMA quality model has been analyzed in a large number of scientific studies. The purpose of this review is to highlight the importance of using six SIGMA metrics in biochemical laboratories and the current application of six SIGMA metrics in all laboratory work procedures. It has been shown that the six SIGMA model can be very useful in improving all phases of laboratory work, as well as that a detailed assessment of all procedures of the phases of work and improvement of the laboratory's quality control system is crucial for the laboratory to have the highest level of six SIGMA. Clinical laboratories should use SIGMA metrics to monitor their performance, as it makes it easier to identify gaps in their performance, thereby improving their efficiency and patient safety. Medical laboratory quality managers should provide a systematic methodology for analyzing and correcting quality assurance systems to achieve Six SIGMA quality-level standards.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71045971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Adenoid cystic carcinoma (ACC) is a rare head and neck malignancy and is likely to be diagnosed in the major salivary glands. It's also known for its slow clinical course and prolonged survival unless no distant metastasis occurs. Even after a long period from the detection of the primary tumor, metastasis to the lung, brain, liver, and bone has a tendency to occur. Case presentation: We report a 53-year-old man who presented with a pathological femur fracture thirteen years after the presentation of submandibular ACC. Our patient reported an improved patient-reported outcome after undergoing resection hemiarthroplasty for his bone metastasis. Conclusion: We tried to accentuate the importance of periodical visits for the probability of distant metastasis and the work-up if it's necessary in such a rare case. It should be kept in mind that proper management of bone metastasis may lead to improvements in the quality of life.
{"title":"Metastasis of submandibular Adenoid cystic carcinoma to the femur bone causing pathological fracture: A case report","authors":"Onur Karaca, Kamil Balaban, Y. Yıldız","doi":"10.5937/sanamed0-40661","DOIUrl":"https://doi.org/10.5937/sanamed0-40661","url":null,"abstract":"Introduction: Adenoid cystic carcinoma (ACC) is a rare head and neck malignancy and is likely to be diagnosed in the major salivary glands. It's also known for its slow clinical course and prolonged survival unless no distant metastasis occurs. Even after a long period from the detection of the primary tumor, metastasis to the lung, brain, liver, and bone has a tendency to occur. Case presentation: We report a 53-year-old man who presented with a pathological femur fracture thirteen years after the presentation of submandibular ACC. Our patient reported an improved patient-reported outcome after undergoing resection hemiarthroplasty for his bone metastasis. Conclusion: We tried to accentuate the importance of periodical visits for the probability of distant metastasis and the work-up if it's necessary in such a rare case. It should be kept in mind that proper management of bone metastasis may lead to improvements in the quality of life.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maja Macura, S. Dugalić, J. Todorović, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, J. Micic, M. Gojnić
Preconception and prenatal monitoring evaluate the condition of the mother's underlying disease and possible complications during pregnancy. Before conception, patients with diabetes should be informed that suboptimal glycoregulation is associated with reduced fertility and pregnancy losses. The task of the perinatologist in pregnancies affected by diabetes mellitus is to prevent complications of the underlying disease, such as hypoglycemic crises. Another important component of prenatal care in diabetic pregnancies is the recognition and prevention of pregnancy complications such as preeclampsia, polyhydramnios, congenital malformations, fetal macrosomia, and infections.
{"title":"Prenatal monitoring of pregnancies complicated by diabetes mellitus","authors":"Maja Macura, S. Dugalić, J. Todorović, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, J. Micic, M. Gojnić","doi":"10.5937/sanamed0-40168","DOIUrl":"https://doi.org/10.5937/sanamed0-40168","url":null,"abstract":"Preconception and prenatal monitoring evaluate the condition of the mother's underlying disease and possible complications during pregnancy. Before conception, patients with diabetes should be informed that suboptimal glycoregulation is associated with reduced fertility and pregnancy losses. The task of the perinatologist in pregnancies affected by diabetes mellitus is to prevent complications of the underlying disease, such as hypoglycemic crises. Another important component of prenatal care in diabetic pregnancies is the recognition and prevention of pregnancy complications such as preeclampsia, polyhydramnios, congenital malformations, fetal macrosomia, and infections.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Todorović, S. Dugalić, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, Olivera Sbutega-Filipović, M. Gojnić
The nutritional needs of diabetic pregnancies are different from normal pregnancies. Differences in nutritional recommendations can also be seen between pregnant women who are using and who are not using insulin therapy. In this literature review, recommendations for different meal proportions of carbohydrates, proteins, and fats in the diets of pregnant women with diabetes mellitus are listed. Different meal plans were also addressed in this group of patients. The role of exercise in the management of diabetes in pregnancy is undeniable and different approaches found in the literature are presented.
{"title":"Nutrition in pregnancy with diabetes mellitus","authors":"J. Todorović, S. Dugalić, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, Olivera Sbutega-Filipović, M. Gojnić","doi":"10.5937/sanamed0-40169","DOIUrl":"https://doi.org/10.5937/sanamed0-40169","url":null,"abstract":"The nutritional needs of diabetic pregnancies are different from normal pregnancies. Differences in nutritional recommendations can also be seen between pregnant women who are using and who are not using insulin therapy. In this literature review, recommendations for different meal proportions of carbohydrates, proteins, and fats in the diets of pregnant women with diabetes mellitus are listed. Different meal plans were also addressed in this group of patients. The role of exercise in the management of diabetes in pregnancy is undeniable and different approaches found in the literature are presented.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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