Introduction: Infantile fibromatosis (IF) is a rare benign mesenchymal tumor of early childhood , located solitarily or multicentrically in the skin, soft tissues, muscles, bones, or visceral organs. The cause is unknown, and some cases are linked to mutations in two different genes. Rapid growth is typical, and while there are reports of spontaneous regression, relapses have also been recorded. Treatment depends on the location of the lesions, with surgery being the main treatment option. Case report: This paper presents an unusual emergency presentation of infantile fibromatosis in a 16-month-old girl, initially manifested as acute laryngitis. The rapid development of respiratory failure necessitated immediate life-saving treatment. Emergency diagnostics revealed a large mass deep within the neck structures, causing significant compression and endangering the airways. The child's condition was critical, and the multidisciplinary team thoroughly discussed available treatment options. Eventually, after careful preparations, the tumormass was surgically removed on the sixth day. The postoperative course was challenging, but the outcome was positive. Pathohistological diagnosis confirmed infantile fibromatosis, and the treatment was successfully completed. Conclusion: Despite its rarity, infantile fibromatosis must be considered a potential cause of urgent, life-threatening conditions in children. Treatment requires individual adaptation and collaboration with a multidisciplinary team.
{"title":"Pediatric emergency of unexpected cause: Infantile fibromatosis: Case report","authors":"Devleta Hadžić, Amela Selimović, Edin Husarić, Almira Ćosićkić, Evlijana Zulić","doi":"10.5937/sanamed0-44771","DOIUrl":"https://doi.org/10.5937/sanamed0-44771","url":null,"abstract":"Introduction: Infantile fibromatosis (IF) is a rare benign mesenchymal tumor of early childhood , located solitarily or multicentrically in the skin, soft tissues, muscles, bones, or visceral organs. The cause is unknown, and some cases are linked to mutations in two different genes. Rapid growth is typical, and while there are reports of spontaneous regression, relapses have also been recorded. Treatment depends on the location of the lesions, with surgery being the main treatment option. Case report: This paper presents an unusual emergency presentation of infantile fibromatosis in a 16-month-old girl, initially manifested as acute laryngitis. The rapid development of respiratory failure necessitated immediate life-saving treatment. Emergency diagnostics revealed a large mass deep within the neck structures, causing significant compression and endangering the airways. The child's condition was critical, and the multidisciplinary team thoroughly discussed available treatment options. Eventually, after careful preparations, the tumormass was surgically removed on the sixth day. The postoperative course was challenging, but the outcome was positive. Pathohistological diagnosis confirmed infantile fibromatosis, and the treatment was successfully completed. Conclusion: Despite its rarity, infantile fibromatosis must be considered a potential cause of urgent, life-threatening conditions in children. Treatment requires individual adaptation and collaboration with a multidisciplinary team.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135733545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: COVID-19 is an infectious disease caused by the severe acute respiratory syndrom coronavirus 2 and causes a series of respiratory symptoms. Considering the appearance and development of symptoms, the course of COVID-19 can go from mild to severe. Depending on the course of COVID-19, the laboratory parameters change a lot, trying to defend the organism against the foreign pathogen and all the changes it causes. Therefore, the aim of this study is to observe the differences between biochemical, hematological and coagulation parameters depending on the disease stage of COVID-19 patients. Material and methods: We conducted cross-sectional study which included 160 COVID-19 patients from Sarajevo, Bosnia and Herzegovina. Biochemical, hematological and coagulation analyzes were performed. Results: COVID-19 patients with a severe clinical course have higher average values of fibrinogen (6.53±4.47,p<0.001), D-dimer (6.89±7.81, p<0.001), APTT (32.05±5.96, p=0.002), eosinophil (0.66±0.09, p=0.002) and CRP (93.42±75.86, p= 0.023), and lower values of lymphocytes (1.04±0.98, p<0.001), monocytes (0.45±0.3, p<0.001), compared to COVID-19 patients with a mild clinical course. COVID-19 patients with a severe clinical course had higher average values of neutrophils (10.12±5.80, p=0.002) and lower values of reactive lymphocytes (0.02±0.03, p<0.001) compared to COVID-19 patients with a mild clinical course. Conclusion: Biochemical, hematological and coagulation parameters can be a sensitive and specific biomarker for distinction of mild and severe COVID-19.
{"title":"Differences between biochemical, hematological, and coagulation parameters among patients with mild and severe COVID-19","authors":"Berina Hasanefendić, Armina Dedić, Sanela Hajro, Emir Šeherčehajić, Almedina Hajrović, R. Alimanović-Alagić, Velda Smajlbegović, Lejla Ibričević-Balić","doi":"10.5937/sanamed0-42725","DOIUrl":"https://doi.org/10.5937/sanamed0-42725","url":null,"abstract":"Introduction: COVID-19 is an infectious disease caused by the severe acute respiratory syndrom coronavirus 2 and causes a series of respiratory symptoms. Considering the appearance and development of symptoms, the course of COVID-19 can go from mild to severe. Depending on the course of COVID-19, the laboratory parameters change a lot, trying to defend the organism against the foreign pathogen and all the changes it causes. Therefore, the aim of this study is to observe the differences between biochemical, hematological and coagulation parameters depending on the disease stage of COVID-19 patients. Material and methods: We conducted cross-sectional study which included 160 COVID-19 patients from Sarajevo, Bosnia and Herzegovina. Biochemical, hematological and coagulation analyzes were performed. Results: COVID-19 patients with a severe clinical course have higher average values of fibrinogen (6.53±4.47,p<0.001), D-dimer (6.89±7.81, p<0.001), APTT (32.05±5.96, p=0.002), eosinophil (0.66±0.09, p=0.002) and CRP (93.42±75.86, p= 0.023), and lower values of lymphocytes (1.04±0.98, p<0.001), monocytes (0.45±0.3, p<0.001), compared to COVID-19 patients with a mild clinical course. COVID-19 patients with a severe clinical course had higher average values of neutrophils (10.12±5.80, p=0.002) and lower values of reactive lymphocytes (0.02±0.03, p<0.001) compared to COVID-19 patients with a mild clinical course. Conclusion: Biochemical, hematological and coagulation parameters can be a sensitive and specific biomarker for distinction of mild and severe COVID-19.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71047223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sönmez Ufuk, Derya Çağlayan, Sarp Singil, Gürsel Ersan, Atalay Sabr
Objective: Hospital-acquired pneumonia (HAP) developing in intensive care units (ICU) is an important problem. Gram-negative bacteria are the most important cause of HAP. Among these bacteria, Klebsiella pneumoniae is among the most important pathogens. The mortality rate for infections caused by carbapenem-resistant Klebsiella pneumoniae is high. Identifying mortality risk factors is crucial to prevent potential deaths. The aim of this study was to determine the risk factors associated with mortality in HAP due to Klebsiella pneumoniae in intensive care unit patients. Material and Methods: This cross-sectional study was conducted between 01. May 2021. and 01. May 2023. in the Anesthesia and Reanimation Intensive Care Unit of Izmir Tepecik Training and Research Hospital. Patients aged 18 years who were diagnosed with hospital-acquired pneumonia due to Klebsiella pneumoniae were included in the study. The dependent variable of the study was 14-day mortality due to Klebsiella pneumoniae pneumonia. Independent variables were presence of COVID-19, bacteremia, ceftazidime/avibactam treatment, intubation, sepsis, Charlson comorbidity score, and laboratory parameters. We conducted logistic regression analysis using the backward elimination method to identify independent predictors of mortality. Results: A total of 176 patients were included in the study. The mean age of the patients was 64.6 ± 16.2 years and 64.2% were male. The 14-day mortality rate was 29% (n:51). In the regression analysis performed to determine the risk factors for mortality; in the univariate regression analysis, day 0 leukocyte count > 10.600/mm3 (OR: 2.31; 95% CI: 1.10-4.84), platelet value < 140.000/mm3 (OR: 2.26; 95% CI: 1.06-4.81), AST > 50 U/L (OR: 2.40; 95% CI: 1.20-4.79) and creatinine > 1.3 mg/dL (OR: 1.96; 95% CI: 1.006-3.82) were associated with mortality. In multivariate regression analysis, a leukocyte count > 10.600/mm3 (OR: 2.30; 95% CI: 1.03-5.14) and an AST > 50 U/L (OR: 2.23; 95% CI: 1.04-4.75) were found to be independent predictors of mortality. Conclusion: In conclusion, leukocytosis and high AST levels were found to be independent risk factors associated with mortality in cases of Klebsiella pneumoniae in the intensive care unit. Taking these factors into account, in addition to other parameters and scores that determine the prognosis of patients, may be useful in reducing mortality.
{"title":"Risk factors for mortality in intensive care unit-acquired pneumonia due to Klebsiella pneumoniae","authors":"Sönmez Ufuk, Derya Çağlayan, Sarp Singil, Gürsel Ersan, Atalay Sabr","doi":"10.5937/sanamed0-46093","DOIUrl":"https://doi.org/10.5937/sanamed0-46093","url":null,"abstract":"Objective: Hospital-acquired pneumonia (HAP) developing in intensive care units (ICU) is an important problem. Gram-negative bacteria are the most important cause of HAP. Among these bacteria, Klebsiella pneumoniae is among the most important pathogens. The mortality rate for infections caused by carbapenem-resistant Klebsiella pneumoniae is high. Identifying mortality risk factors is crucial to prevent potential deaths. The aim of this study was to determine the risk factors associated with mortality in HAP due to Klebsiella pneumoniae in intensive care unit patients. Material and Methods: This cross-sectional study was conducted between 01. May 2021. and 01. May 2023. in the Anesthesia and Reanimation Intensive Care Unit of Izmir Tepecik Training and Research Hospital. Patients aged 18 years who were diagnosed with hospital-acquired pneumonia due to Klebsiella pneumoniae were included in the study. The dependent variable of the study was 14-day mortality due to Klebsiella pneumoniae pneumonia. Independent variables were presence of COVID-19, bacteremia, ceftazidime/avibactam treatment, intubation, sepsis, Charlson comorbidity score, and laboratory parameters. We conducted logistic regression analysis using the backward elimination method to identify independent predictors of mortality. Results: A total of 176 patients were included in the study. The mean age of the patients was 64.6 ± 16.2 years and 64.2% were male. The 14-day mortality rate was 29% (n:51). In the regression analysis performed to determine the risk factors for mortality; in the univariate regression analysis, day 0 leukocyte count > 10.600/mm3 (OR: 2.31; 95% CI: 1.10-4.84), platelet value < 140.000/mm3 (OR: 2.26; 95% CI: 1.06-4.81), AST > 50 U/L (OR: 2.40; 95% CI: 1.20-4.79) and creatinine > 1.3 mg/dL (OR: 1.96; 95% CI: 1.006-3.82) were associated with mortality. In multivariate regression analysis, a leukocyte count > 10.600/mm3 (OR: 2.30; 95% CI: 1.03-5.14) and an AST > 50 U/L (OR: 2.23; 95% CI: 1.04-4.75) were found to be independent predictors of mortality. Conclusion: In conclusion, leukocytosis and high AST levels were found to be independent risk factors associated with mortality in cases of Klebsiella pneumoniae in the intensive care unit. Taking these factors into account, in addition to other parameters and scores that determine the prognosis of patients, may be useful in reducing mortality.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mina Cvjetković-Bošnjak, Željko Bibić, Dušan Kuljančić
Introduction: Serotonin syndrome is a rare but potentially life-threatening condition. In most cases, this complication is caused by taking two serotonergic medications simultaneously, leading to excessive serotonin concentration in the body. Selective serotonin reuptake inhibitors (SSRIs), selective serotonin and norepinephrine reuptake inhibitors (SNRIs), as well as irreversible monoamine oxidase inhibitors (MAOIs) and their combination with other serotonergic substances, are associated with symptoms of serotonin syndrome. Case study: A patient who was prescribed sertraline (an SSRI) for a depressive episode suffered fractures in a traffic accident during the treatment, and tramadol was prescribed for her pain. Since both drugs tend to increase serotonin levels in the body, a complication in the form of serotonin syndrome developed. With timely recognition and treatment, the symptoms of serotonin syndrome resolved without lasting consequences. Conclusion: Numerous drugs and substances can induce serotonin syndrome, often in combination with antidepressants. Therefore, it is of great importance that doctors are aware of comorbid conditions that necessitate the use of the mentioned drugs in order to prevent serotonin syndrome. If it does occur, adequate and successful treatment is crucial.
{"title":"Serotonin syndrome in a patient with dual diagnosis: Case study","authors":"Mina Cvjetković-Bošnjak, Željko Bibić, Dušan Kuljančić","doi":"10.5937/sanamed0-45500","DOIUrl":"https://doi.org/10.5937/sanamed0-45500","url":null,"abstract":"Introduction: Serotonin syndrome is a rare but potentially life-threatening condition. In most cases, this complication is caused by taking two serotonergic medications simultaneously, leading to excessive serotonin concentration in the body. Selective serotonin reuptake inhibitors (SSRIs), selective serotonin and norepinephrine reuptake inhibitors (SNRIs), as well as irreversible monoamine oxidase inhibitors (MAOIs) and their combination with other serotonergic substances, are associated with symptoms of serotonin syndrome. Case study: A patient who was prescribed sertraline (an SSRI) for a depressive episode suffered fractures in a traffic accident during the treatment, and tramadol was prescribed for her pain. Since both drugs tend to increase serotonin levels in the body, a complication in the form of serotonin syndrome developed. With timely recognition and treatment, the symptoms of serotonin syndrome resolved without lasting consequences. Conclusion: Numerous drugs and substances can induce serotonin syndrome, often in combination with antidepressants. Therefore, it is of great importance that doctors are aware of comorbid conditions that necessitate the use of the mentioned drugs in order to prevent serotonin syndrome. If it does occur, adequate and successful treatment is crucial.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Distal femoral shaft fractures are characterized by their increasing incidence and complexity, presenting a significant challenge in management. The objective of this retrospective study was to compare the clinical and radiological results of patients with extra-articular distal third femoral shaft fractures treated using either retrograde Talon Distal Fix nail or a distal femur locking plate. Material and Method: The study comprised 40 patients aged > 18 years who presented at our hospital with a distal third femoral shaft fracture between January 2017 and January 2023. The patients were divided into two groups: Group TDN, treated with retrograde Talon Distal Fix nailing (n = 18), and Group DLP, treated with a distal locking plate (n = 22). Demographic data, follow-up period, operating time, time to union, range of motion (ROM), mechanism of injury (traffic accident, fall from height, workplace accident, gunshot injury), fracture type, complications, and surgical method were retrospectively recorded. Clinical evaluation included deformity, knee ROM, pain, and the knee total score (KSS) for walking and knee stability. Results: The mean age of the patients was 48.03 ± 12.31 (min-max: 23-69) years, and the mean follow up time for all patients was 15.88 ± 2.32 (12-21) months. The mean time to union was 25.55 ± 1.86 (22-30) weeks. Delayed union and non-union rates were similar between the research groups (P = 1.000, P = 0.673, respectively). Union time (weeks) and mean ROM were not significantly different between the groups (P = 0.881, P = 0.892, respectively). The mean operation time of the TDF group (48.78 ± 3.94 minutes) was significantly lower than that of the DLP group (62.45 ± 3.33 minutes) (P < 0.001). The mean blood loss values of the TDF group (267.5 ± 32.4) were significantly lower than those of the DLP group (324.1 ± 20.2) (P < 0.001). Conclusion: This study demonstrated that both retrograde talon nails and locking plates provided satisfactory clinical and radiological results in the management of distal third femoral shaft fractures. Moreover, the retrograde talon nail offered the advantages of a shorter operating time and less intraoperative blood loss.
{"title":"Retrograde talon intramedullary nails versus distal locking plates in the management of extra-articular distal femoral shaft fractures","authors":"Abdulrahim Dundar, Deniz Ipek, Kaya Şehmuz","doi":"10.5937/sanamed0-45059","DOIUrl":"https://doi.org/10.5937/sanamed0-45059","url":null,"abstract":"Introduction: Distal femoral shaft fractures are characterized by their increasing incidence and complexity, presenting a significant challenge in management. The objective of this retrospective study was to compare the clinical and radiological results of patients with extra-articular distal third femoral shaft fractures treated using either retrograde Talon Distal Fix nail or a distal femur locking plate. Material and Method: The study comprised 40 patients aged > 18 years who presented at our hospital with a distal third femoral shaft fracture between January 2017 and January 2023. The patients were divided into two groups: Group TDN, treated with retrograde Talon Distal Fix nailing (n = 18), and Group DLP, treated with a distal locking plate (n = 22). Demographic data, follow-up period, operating time, time to union, range of motion (ROM), mechanism of injury (traffic accident, fall from height, workplace accident, gunshot injury), fracture type, complications, and surgical method were retrospectively recorded. Clinical evaluation included deformity, knee ROM, pain, and the knee total score (KSS) for walking and knee stability. Results: The mean age of the patients was 48.03 ± 12.31 (min-max: 23-69) years, and the mean follow up time for all patients was 15.88 ± 2.32 (12-21) months. The mean time to union was 25.55 ± 1.86 (22-30) weeks. Delayed union and non-union rates were similar between the research groups (P = 1.000, P = 0.673, respectively). Union time (weeks) and mean ROM were not significantly different between the groups (P = 0.881, P = 0.892, respectively). The mean operation time of the TDF group (48.78 ± 3.94 minutes) was significantly lower than that of the DLP group (62.45 ± 3.33 minutes) (P < 0.001). The mean blood loss values of the TDF group (267.5 ± 32.4) were significantly lower than those of the DLP group (324.1 ± 20.2) (P < 0.001). Conclusion: This study demonstrated that both retrograde talon nails and locking plates provided satisfactory clinical and radiological results in the management of distal third femoral shaft fractures. Moreover, the retrograde talon nail offered the advantages of a shorter operating time and less intraoperative blood loss.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136138364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and aim: Gastroesophageal reflux disease (GERD) is a common disease in the world. GERD is always treated with drugs. The Bravo® wireless pH monitoring system is a good technique. The Bravo® may affect increasing the specificity and sensitivity in the diagnosis of GERD with its 48-hour recording feature. In this study, we aimed to assess the diagnostic performance of the Bravo® pH monitoring system in patients with non-erosive GERD. Materials and Methods: Patients with non-erosive reflux disease (normal endoscopy) whose symptoms persisted after PPI treatment (at least two months) were included in the study. All patients had upper gastrointestinal system endoscopies performed in our clinic between January 2013 and December 2019. All patients had a 48-hour Bravo® wireless pH monitoring record. Results: Twenty-three patients (M: 18 (78.3%; Age:35.7±11) were included in the study. All patients completed the 2-day recording protocol. During and after the procedure, no patient showed any adverse effects of the Bravo® procedure. We diagnosed GERD in 13 of 23 patients by Bravo® capsule. According to the Bravo® pH-meter recordings; Total time pH<4 (minute) was 187±190, the total number of refluxes was 90±61, the percentage of time with pH<4 was 7.1±7.22, the number of long reflux events were 8.1±8, the duration of the longest reflux episode during pH<4 (minute) was 31±49, the Demeester score was 20.8±19.3 detected. Conclusion: Based on the results of the current study, the Bravo® pH monitoring system is a practical and effective diagnostic technique for non-erosive GERD. Further prospective studies would be useful for comparing the differences between 24-hour and 48-hour pH recording results.
{"title":"THE ASSESSMENT OF PATIENTS WITH NON-EROSIVE GASTROESOPHAGEAL REFLUX DISEASE BY USING THE BRAVO® PH MONITORING SYSTEM","authors":"M. Gok, G. Gençdal","doi":"10.5937/sanamed17-39523","DOIUrl":"https://doi.org/10.5937/sanamed17-39523","url":null,"abstract":"Background and aim: Gastroesophageal reflux disease (GERD) is a common disease in the world. GERD is always treated with drugs. The Bravo® wireless pH monitoring system is a good technique. The Bravo® may affect increasing the specificity and sensitivity in the diagnosis of GERD with its 48-hour recording feature. In this study, we aimed to assess the diagnostic performance of the Bravo® pH monitoring system in patients with non-erosive GERD. \u0000Materials and Methods: Patients with non-erosive reflux disease (normal endoscopy) whose symptoms persisted after PPI treatment (at least two months) were included in the study. All patients had upper gastrointestinal system endoscopies performed in our clinic between January 2013 and December 2019. All patients had a 48-hour Bravo® wireless pH monitoring record. \u0000Results: Twenty-three patients (M: 18 (78.3%; Age:35.7±11) were included in the study. All patients completed the 2-day recording protocol. During and after the procedure, no patient showed any adverse effects of the Bravo® procedure. We diagnosed GERD in 13 of 23 patients by Bravo® capsule. According to the Bravo® pH-meter recordings; Total time pH<4 (minute) was 187±190, the total number of refluxes was 90±61, the percentage of time with pH<4 was 7.1±7.22, the number of long reflux events were 8.1±8, the duration of the longest reflux episode during pH<4 (minute) was 31±49, the Demeester score was 20.8±19.3 detected. \u0000Conclusion: Based on the results of the current study, the Bravo® pH monitoring system is a practical and effective diagnostic technique for non-erosive GERD. Further prospective studies would be useful for comparing the differences between 24-hour and 48-hour pH recording results.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42425945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Verica Misanovix, Edna Hodžić, S. Terzić, Emina Vukas-Salihbegović, Amila Ključić
Introduction: Seizures are one of the most common pathologies in newborns. Their incidence is 1.5–3.5/1000 for term infants and 10–130/1000 for preterms. The most common causes of seizures in term infants are hypoxic-ischemic encephalopathy (HIE), cerebrovascular insult (CVI), cerebral malformations (CM), and metabolic disorders. For preterm infants: intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and infections. Clinical characteristics are diverse and subtle, and subclinical forms are common. The drug of the first choice is phenobarbitone. Newborns with seizures are more prone to developing neurological disturbances such as epilepsy and cerebral palsy. Methods: This is a clinical, observational research, one-year, retrospective, cross-sectional study conducted in the Department of neonatal intensive care and neonatology of the Clinic of Pediatrics KCUS. The study included 43 newborns who met the inclusion criteria. Results: We found that 7.19% of hospitalized newborns had seizures. A number of seizures were recorded in the group of term infants with an earlier time of seizures. The most common etiological causes were: HIE, IVH, infections, and CM. There was a frequent occurrence of metabolic disorders such as acidosis, blood sugar, and mineral (Ca, K, Na, and Mg) disorders. The median of the first day of onset of seizures in full-term infants is on the fourth day, while in premature infants it is on the sixth day of life. Phenobarbitone was mainly used to stop seizures, with great success. Overall mortality in children with seizures was 37.21%. Conclusions: Seizures are common in newborns, which, depending on the etiological cause, increase mortality, especially in preterm infants. Seizures in term infants occur earlier than in premature infants. The most common etiology of seizures in term infants are infections, hypoxemic-ischemic encephalopathy, intracranial hemorrhage, cerebral malformations, and cerebrovascular insult. In premature infants these are hypoxemic-ischemic encephalopathy, intracranial bleeding, and infections. In the initial treatment of neonatal convulsions, phenobarbitone is most often used, which has proven to be successful in the majority of cases.
{"title":"NEONATAL SEIZURES: ETIOLOGY, TREATMENT AND PROGNOSIS","authors":"Verica Misanovix, Edna Hodžić, S. Terzić, Emina Vukas-Salihbegović, Amila Ključić","doi":"10.5937/sanamed17-39819","DOIUrl":"https://doi.org/10.5937/sanamed17-39819","url":null,"abstract":"Introduction: Seizures are one of the most common pathologies in newborns. Their incidence is 1.5–3.5/1000 for term infants and 10–130/1000 for preterms. The most common causes of seizures in term infants are hypoxic-ischemic encephalopathy (HIE), cerebrovascular insult (CVI), cerebral malformations (CM), and metabolic disorders. For preterm infants: intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and infections. Clinical characteristics are diverse and subtle, and subclinical forms are common. The drug of the first choice is phenobarbitone. Newborns with seizures are more prone to developing neurological disturbances such as epilepsy and cerebral palsy. \u0000Methods: This is a clinical, observational research, one-year, retrospective, cross-sectional study conducted in the Department of neonatal intensive care and neonatology of the Clinic of Pediatrics KCUS. The study included 43 newborns who met the inclusion criteria. \u0000Results: We found that 7.19% of hospitalized newborns had seizures. A number of seizures were recorded in the group of term infants with an earlier time of seizures. The most common etiological causes were: HIE, IVH, infections, and CM. There was a frequent occurrence of metabolic disorders such as acidosis, blood sugar, and mineral (Ca, K, Na, and Mg) disorders. The median of the first day of onset of seizures in full-term infants is on the fourth day, while in premature infants it is on the sixth day of life. Phenobarbitone was mainly used to stop seizures, with great success. Overall mortality in children with seizures was 37.21%. \u0000Conclusions: Seizures are common in newborns, which, depending on the etiological cause, increase mortality, especially in preterm infants. Seizures in term infants occur earlier than in premature infants. The most common etiology of seizures in term infants are infections, hypoxemic-ischemic encephalopathy, intracranial hemorrhage, cerebral malformations, and cerebrovascular insult. In premature infants these are hypoxemic-ischemic encephalopathy, intracranial bleeding, and infections. In the initial treatment of neonatal convulsions, phenobarbitone is most often used, which has proven to be successful in the majority of cases.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44956652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Terzić, Dubravka Radonjic, M. Paunović, A. Ljaljević, Miloš Bojić
Introduction: Neurofibromas are benign tumors of neuronal origin, occurring most commonly in young adults, with no gender predilection. The connection of neurofibroma with disorders on a general level as von Recklinghausen’s disease makes its diagnosis critical. Case report: A 32-old female patient was administered to the Clinic of Plastic surgery, Clinical Center of Montenegro in Podgorica, with a 10-year history of painless, subcutaneous tumor of the right upper arm that grew in size over the last ten years. The patient reported progressive pain and tingling in her right forearm and right hand for the last 12 months. An MRI showed a non-homogenous tumor of the middle third portion of the triceps muscle, in close contact with the humerus but without infiltrating it. The tumor was removed, with a definitive histopathological result of a solitary benign neurofibroma. Conclusions: This example of successful treatment of solitary neurofibroma may serve to increase the awareness of surgeons and radiologists in small countries regarding benign peripheral nerve sheath tumors. The patient is under observation for two years with no signs of relapse and no other features indicative of neurofibromatosis type 1.
{"title":"LARGE SOLITARY ENCAPSULATED NEUROFIBROMA OF UPPER ARM – A CASE REPORT","authors":"Z. Terzić, Dubravka Radonjic, M. Paunović, A. Ljaljević, Miloš Bojić","doi":"10.5937/sanamed17-36810","DOIUrl":"https://doi.org/10.5937/sanamed17-36810","url":null,"abstract":"Introduction: Neurofibromas are benign tumors of neuronal origin, occurring most commonly in young adults, with no gender predilection. The connection of neurofibroma with disorders on a general level as von Recklinghausen’s disease makes its diagnosis critical. Case report: A 32-old female patient was administered to the Clinic of Plastic surgery, Clinical Center of Montenegro in Podgorica, with a 10-year history of painless, subcutaneous tumor of the right upper arm that grew in size over the last ten years. The patient reported progressive pain and tingling in her right forearm and right hand for the last 12 months. An MRI showed a non-homogenous tumor of the middle third portion of the triceps muscle, in close contact with the humerus but without infiltrating it. The tumor was removed, with a definitive histopathological result of a solitary benign neurofibroma. Conclusions: This example of successful treatment of solitary neurofibroma may serve to increase the awareness of surgeons and radiologists in small countries regarding benign peripheral nerve sheath tumors. The patient is under observation for two years with no signs of relapse and no other features indicative of neurofibromatosis type 1.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48415293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Turkey has adopted outpatient treatment of COVID-19 since the beginning of the pandemic. In the outpatient treatment of COVID-19 in Turkey, only hydroxychloroquine was initially used, favipiravir was added to the treatment, and finally, hydroxychloroquine was removed from the treatment and only favipiravir was used. Our study aims to examine the adherence to the recommended treatment of people diagnosed with COVID-19 who have received outpatient treatment without hospitalization and their attitudes and declared behaviors towards using the medications they were given free of charge. Methods: This follow-up study was conducted between February 15, 2021, and May 15, 2021, by telephone survey method in the Lüleburgaz District of Kırklareli City. The study participants were 4368 people who were diagnosed with COVID-19 with a positive PCR test in Lüleburgaz District between February 15 and May 15, 2021, and were given hydroxychloroquine and/or favipiravir drugs for home use after being deemed suitable for outpatient treatment according to the guidelines of the Republic of Turkey Ministry of Health. Results: 88.1% (n=3849) of the survey respondents reported using the given medications regularly, while 11.9% (n=519) did not use them regularly. The most important socio demographic factor affecting the regular use was age, and the patient-centered factor was the sense of trust. Conclusion: In the fight against COVID-19, measures to increase the sense of trust of patients who are expected to adhere to the treatments should be considered a priority.
{"title":"TREATMENT ADHERENCE OF COVID-19 PATIENTS GETTING MEDICATION AT HOME","authors":"Ahmet Önder Porsuk, Ç. Ceri̇t","doi":"10.5937/sanamed17-36529","DOIUrl":"https://doi.org/10.5937/sanamed17-36529","url":null,"abstract":"Introduction: Turkey has adopted outpatient treatment of COVID-19 since the beginning of the pandemic. In the outpatient treatment of COVID-19 in Turkey, only hydroxychloroquine was initially used, favipiravir was added to the treatment, and finally, hydroxychloroquine was removed from the treatment and only favipiravir was used. Our study aims to examine the adherence to the recommended treatment of people diagnosed with COVID-19 who have received outpatient treatment without hospitalization and their attitudes and declared behaviors towards using the medications they were given free of charge. \u0000Methods: This follow-up study was conducted between February 15, 2021, and May 15, 2021, by telephone survey method in the Lüleburgaz District of Kırklareli City. The study participants were 4368 people who were diagnosed with COVID-19 with a positive PCR test in Lüleburgaz District between February 15 and May 15, 2021, and were given hydroxychloroquine and/or favipiravir drugs for home use after being deemed suitable for outpatient treatment according to the guidelines of the Republic of Turkey Ministry of Health. \u0000Results: 88.1% (n=3849) of the survey respondents reported using the given medications regularly, while 11.9% (n=519) did not use them regularly. The most important socio demographic factor affecting the regular use was age, and the patient-centered factor was the sense of trust. Conclusion: In the fight against COVID-19, measures to increase the sense of trust of patients who are expected to adhere to the treatments should be considered a priority.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48011352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ivana Meta Jevtovic, Bojan Djokic, Miroslav S. Tomovic, Zorana Kovačević, Katarina M. Janicijevic
With the fall of the medieval Serbian state under Turkish rule, every culture, including medicine, died out, and the people resorted to folk medicine and self-taught doctors, i.e. empiricists. Serbs began to get educated in Vienna and Pest, and there were Serbian doctors in Novi Sad already at the beginning of the 18th century. At that time, the first doctors with diplomas appeared in Serbia, but mostly as personal doctors of the Belgrade pasha or Knez Miloš, i.e. his brother Jevrem in Šabac. In the fourth decade of the 19th century, the first military doctors set out, and the newly created four military district commands got their doctors. The Serbian Medical Association started the first medical journal, "Serbian Archives" in 1874. Josif Pancic is writing the first textbook in natural sciences, and Dr. Acim Medovic is writing the first textbook on forensic medicine. Before the First Serbian-Turkish War, the civilian ambulance numbered 69 doctors, 10 medical assistants, 26 pharmacists, and five pharmacy assistants, while the military ambulance had 19 doctors, five medical assistants, one pharmacist, and four pharmacy assistants. Health was initiated but also the establishment of the Ministry of Health and the higher education institution of the Medical Faculty in Belgrade. Guided by the oath, expertise, and experience, the doctors of that time made a significant effort to improve and develop medicine in Serbia in the 19th century.
{"title":"A DEVELOPMENT OF SERBIAN MEDICINE IN THE 19TH CENTURY","authors":"Ivana Meta Jevtovic, Bojan Djokic, Miroslav S. Tomovic, Zorana Kovačević, Katarina M. Janicijevic","doi":"10.5937/sanamed17-37207","DOIUrl":"https://doi.org/10.5937/sanamed17-37207","url":null,"abstract":"With the fall of the medieval Serbian state under Turkish rule, every culture, including medicine, died out, and the people resorted to folk medicine and self-taught doctors, i.e. empiricists. Serbs began to get educated in Vienna and Pest, and there were Serbian doctors in Novi Sad already at the beginning of the 18th century. At that time, the first doctors with diplomas appeared in Serbia, but mostly as personal doctors of the Belgrade pasha or Knez Miloš, i.e. his brother Jevrem in Šabac. In the fourth decade of the 19th century, the first military doctors set out, and the newly created four military district commands got their doctors. The Serbian Medical Association started the first medical journal, \"Serbian Archives\" in 1874. Josif Pancic is writing the first textbook in natural sciences, and Dr. Acim Medovic is writing the first textbook on forensic medicine. Before the First Serbian-Turkish War, the civilian ambulance numbered 69 doctors, 10 medical assistants, 26 pharmacists, and five pharmacy assistants, while the military ambulance had 19 doctors, five medical assistants, one pharmacist, and four pharmacy assistants. Health was initiated but also the establishment of the Ministry of Health and the higher education institution of the Medical Faculty in Belgrade. Guided by the oath, expertise, and experience, the doctors of that time made a significant effort to improve and develop medicine in Serbia in the 19th century. ","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47744503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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