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Monitoring and Analyzing of the Relationship between Climatic Elements and Skin Cancer in the Years 2012-2014 2012-2014年气候要素与皮肤癌关系的监测与分析
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8152
Mostafa Dastorani, Vahid Safarianzengir, B. Salahi
Introduction: The present study investigated one of these types of disease (skin cancer) and its relationship with climatic parameters. The aim of this study was to investigate the relationship between climate change and skin cancer in Ardabil province. Materials and Methods: This descriptive correlational study was conducted to investigate the effect of six climatic parameters (frost, sunny hours, minimum mean humidity, maximum absolute temperature, minimum absolute temperature, and mean temperature) on skin cancer in Ardabil province in a 3-year statistical period (2012-2014). The data were analyzed using the Spearman correlation relationship in SPSS version 24 software, also Minitab version 16 software was used for linear interpolation. Results: According to the findings, the highest correlation (more than 95%) of skin cancer in three cities of Parsabad, Khalkhal, and Ardabil with the climatic parameter was related to minimum absolute temperature. However, in Khalkhal station in three years of study, sunny hours had the highest correlation and the lowest correlation was related to glacial climate parameter in all four cities. It can be said that the factors of sunny hours and maximum temperature have an effect on the incidence of skin cancer, and the minimum absolute temperature increases the exacerbation of this type of disease. Conclusion: According to the results of statistical correlation and the effects of climatic parameters on skin cancer, it can be concluded that climate parameters are one of the effective factors in skin cancer.
本研究调查了其中一种疾病(皮肤癌)及其与气候参数的关系。本研究的目的是调查阿达比勒省气候变化与皮肤癌之间的关系。材料与方法:采用描述性相关研究方法,对2012-2014年3年统计期阿达比尔省6个气候参数(霜冻、日照时数、最低平均湿度、最高绝对温度、最低绝对温度和平均温度)对皮肤癌的影响进行研究。采用SPSS version 24软件进行Spearman相关关系分析,并采用Minitab version 16软件进行线性插值。结果:根据研究结果,在Parsabad、Khalkhal和Ardabil三个城市,皮肤癌与气候参数的最高相关性(超过95%)与最低绝对温度有关。而在Khalkhal站3年的研究中,4个城市的日照时数与冰川气候参数的相关性最高,相关性最低。可以说,日照时数和最高气温等因素对皮肤癌的发病率都有影响,而最低绝对气温则增加了这类疾病的加重。结论:根据统计相关结果和气候参数对皮肤癌的影响,可以得出气候参数是皮肤癌发生的有效因素之一。
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引用次数: 0
The Effect of Water Boiled in Aluminum Cookwares on Genomic Abnormalities in the Meristematic Cells of Onion Root 铝锅煮水对洋葱根分生组织细胞基因组异常的影响
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8150
Fathiyeh Ekhlasi, Zahra Zendehboodi
Introduction: One of the ways of human exposure to aluminum (Al) is Al food packaging materials and cookwares. Although many studies have examined the biotic influence of nanoparticles or ionic form of heavy metals, there are limited studies conducted on the possible health risks of metals in the form of alloy used for making utensils. In this study, the effect of water boiled in Al cookwares with defined concentrations of Al on the genomic abnormalities and cell division of meristematic cells of onion root was evaluated using Allium cepa assay. Materials and Methods: The onion roots were treated with water boiled in Al utensils (three pots) with different concentrations of Al (5 and 10 mg/l) for 42 to 43 hours and then analyzed for mitotic index (MI) and mitotic phase aberrations (MPA). Results: The percent of MI in the study groups treated with 5 mg/l of Al from pot 1 and 10 mg/l from all pots increased significantly compared to the control group (P < 0.05). Also, the frequency of total MPA in all Al treated groups significantly increased compared to the control group (P < 0.05). The most significant results were derived by sticky chromosomes, anaphase bridge, going ahead chromosome and disturbed mitosis, respectively. Conclusion: The result of this study confirmed the genotoxic effect of water boiled in Al cookwares containing the examined range of Al concentrations on the meristematic cells of onion root.
简介:人类接触铝的方式之一是铝食品包装材料和炊具。尽管许多研究已经检测了纳米颗粒或离子形式的重金属对生物的影响,但对用于制造餐具的合金形式的金属可能存在的健康风险的研究有限。在本研究中,使用洋葱测定法评估了在具有特定浓度Al的Al炊具中煮沸的水对洋葱根分生组织细胞的基因组异常和细胞分裂的影响。材料和方法:用不同浓度Al(5和10mg/l)的Al器皿(三个锅)煮沸洋葱根42至43小时,然后分析有丝分裂指数(MI)和有丝分裂期畸变(MPA)。结果:与对照组相比,第1罐铝5mg/l和所有罐铝10mg/l处理组的MI百分比显著增加(P<0.05)。此外,所有铝处理组的总MPA频率均显著高于对照组(P<0.05),进行染色体和干扰有丝分裂。结论:本研究结果证实了在所检测的Al浓度范围内的Al炊具中煮沸的水对洋葱根分生组织细胞的遗传毒性作用。
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引用次数: 0
Household Food Insecurity Scores are Higher among Adults Infected with COVID-19: A Cross-Sectional Online Study among an Iranian Population 感染COVID-19的成年人家庭粮食不安全得分更高:伊朗人口的横断面在线研究
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8151
N. Kalantari, H. Eini-Zinab, N. Ezzeddin, N. Miri
Introduction: Food insecurity has negative impacts on health, including the function of the immune system. The association between food insecurity and COVID-19 infection rates has not been fully understood. This study aimed to examine whether food-insecure households are more vulnerable to COVID-19 infection. Materials and Methods: This online cross-sectional study was conducted on 2,871 Iranian adults (31 provinces), from August to September 2020. Demographic and socio-economic information was collected using a questionnaire. The Household Food Insecurity Access Scale (HFIAS) was used for assessing household food insecurity. The data analysis was performed by SPSS.22, using Chi-square test, ANOVA test, and Multinomial Logistic Regression Model. Results: The findings indicated that healthcare personnel were at higher risk of COVID-19 (CI = 1.90, 7.05; OR = 3.66; P < 0.001). It was also shown that HFIAS scores were significantly higher among infected people compared to non-infected (CI = 1.00, 1.05; OR = 1.03; P < 0.05). Women were at lower risk of infection compared to men (CI = 0.41, 0.87; OR = 0.60; P < 0.05). Conclusions: Based on the results, in addition to long-term policies to improve food security, policymakers are recommended to implement short-term policies to reduce the vulnerability of the community to COVID-19 virus.
粮食不安全对健康有负面影响,包括免疫系统的功能。粮食不安全与COVID-19感染率之间的关系尚未得到充分了解。这项研究旨在调查粮食不安全家庭是否更容易感染COVID-19。材料和方法:这项在线横断面研究于2020年8月至9月对2,871名伊朗成年人(31个省)进行。使用调查表收集了人口和社会经济资料。家庭粮食不安全获取量表(HFIAS)用于评估家庭粮食不安全状况。数据分析采用SPSS.22软件,采用卡方检验、方差分析检验和多项Logistic回归模型。结果:卫生保健人员感染COVID-19的风险较高(CI = 1.90, 7.05;Or = 3.66;P < 0.001)。感染人群的HFIAS评分明显高于未感染人群(CI = 1.00, 1.05;Or = 1.03;P < 0.05)。与男性相比,女性感染风险较低(CI = 0.41, 0.87;Or = 0.60;P < 0.05)。结论:根据研究结果,建议政策制定者除了实施改善粮食安全的长期政策外,还应实施短期政策,以降低社区对COVID-19病毒的脆弱性。
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引用次数: 2
Occurrence and Removal of Macrolides in Municipal Wastewater Treatment Plants: A Review 大环内酯类化合物在城市污水处理厂中的发生与去除
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8149
Z. Abbasi, Mehdi Ahmadi
Introduction: Macrolides are a group of antibacterial agents. Given their clinical importance, and the consistent rise in resistance among pathogenic bacteria, macrolides have been the targets of extensive research. Materials and Methods: This review considered the number of macrolides in different wastewater and the removal of these drugs. The antibiotics were frequently detected in influents and effluents, ranged from ng/L up to lower μg/L. In influent, the highest concentrations of clarithromycin (6080 ng/L), roxithromycin (>103 ng/L), erythromycin (3900 ng/L), and azithromycin (1949 ng/L) were detected in Croatia, Chinese, USA, and Singapore municipal wastewater treatment plants, respectively. Results: The removal efficiency of macrolides during wastewater treatment processes varies and is essentially dependent on a combination of macrolides physicochemical properties, location of municipal wastewater, and the operating conditions of the treatment systems. The application of alternative techniques, including membrane separation, activated carbon adsorption, advanced oxidation processes, biodegradation, and disinfection were the dominant removal routes for macrolides in different wastewater treatment processes. A combination of these techniques can also be used, leading to higher removals, which may be necessary before the final disposal of the effluents or their reuse for irrigation or groundwater recharge. Conclusion: Many antibiotics cannot be removed completely in wastewater treatment processes and would enter into the environment via effluent and sludge. The molecular structure of macrolides and their load-bearing capacity has led to the advantage of biological treatment over other treatments. However, the main part of the treatment has been done using biological treatment.
简介:大环内酯类是一类抗菌剂。鉴于大环内酯类药物在临床上的重要性,以及致病菌耐药性的持续上升,它们一直是广泛研究的目标。材料和方法:本综述考虑了不同废水中大环内酯类药物的数量以及这些药物的去除。在污水和污水中经常检测到抗生素,浓度从ng/L到较低的μg/L。进水中,克拉霉素(6080ng/L)、罗红霉素(>103ng/L),红霉素(3900 ng/L)和阿奇霉素(1949 ng/L)的最高浓度分别在克罗地亚、中国、美国和新加坡的城市污水处理厂检测到。结果:在废水处理过程中,大环内酯类化合物的去除效率各不相同,主要取决于大环内酯的物理化学性质、城市废水的位置和处理系统的操作条件。在不同的废水处理过程中,膜分离、活性炭吸附、高级氧化工艺、生物降解和消毒等替代技术的应用是大环内酯类化合物的主要去除途径。这些技术的结合也可以使用,从而产生更高的清除率,这在最终处理废水或将其重新用于灌溉或地下水补给之前可能是必要的。结论:许多抗生素在污水处理过程中不能完全去除,会通过污水和污泥进入环境。大环内酯类化合物的分子结构及其承载能力使生物处理比其他处理具有优势。然而,治疗的主要部分是使用生物治疗。
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引用次数: 0
Assessment Optimization of Safety and Health Risks Using Fuzzy TOPSIS Technique (Case Study: Construction Sites in the South of Iran) 基于模糊TOPSIS技术的安全与健康风险评估优化(以伊朗南部建筑工地为例)
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8154
E. Sekhavati, R. Jalilzadeh Yengejeh
Introduction: Safety and health risk assessment in industries is associated with uncertainties due to the variables affecting it. Therefore, in this research, optimizing safety and health risk assessment was investigated in construction sites by combining a multi-criteria decision-making technique (TOPSIS) and a fuzzy system. In the present study, to answer this question, a new method was used to optimize health risk assessment in construction workshops. Materials and Methods: The case study was construction sites in Lar, a city in the south of Iran. Based on previous studies and expert opinions, ten criteria were determined to assess safety and health risks in the construction sites. Also, 15 safety and health risks were identified resulting from 12 types of activities in the construction sites. Triangular fuzzy numbers were used for linguistic variables in Fuzzy TOPSIS with R version 1.1 software. Results: Based on the results, the risk of the collapse of adjacent buildings related to the excavation process was the most important safety and health risk in the construction sites with a coefficient value of 0.5. Conclusion: This method can provide desired results with the least uncertainty in prioritizing safety and health risks.
引言:工业安全健康风险评估因其影响因素的存在而存在不确定性。因此,本研究采用多准则决策技术(TOPSIS)和模糊系统相结合的方法,对建筑工地安全健康风险评价进行了优化研究。在本研究中,为了回答这个问题,采用了一种新的方法来优化建筑车间的健康风险评估。材料与方法:以伊朗南部城市拉尔的建筑工地为研究对象。根据以往的研究和专家意见,确定了十项标准来评估建筑工地的安全和健康风险。此外,在建筑工地的12种活动中,还发现了15种安全和健康风险。在R版本1.1的模糊TOPSIS软件中,三角模糊数被用于语言变量。结果:根据结果,与开挖过程相关的相邻建筑物倒塌风险是施工现场最重要的安全和健康风险,系数为0.5。结论:该方法可以在优先考虑安全和健康风险方面以最小的不确定性提供期望的结果。
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引用次数: 3
Effects of Extreme Ambient Temperature on Cardiovascular Outcomes: A Systematic Review 极端环境温度对心血管结局的影响:一项系统综述
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8148
S. Moslehi, M. Dowlati
Introduction: Extreme weather or climate, including heat waves and cold waves, is considered a health issue causing adverse effects on health, such as cardiovascular diseases (CVDs), mortality and morbidity. Thus, this systematic review aimed to study the impacts of extreme ambient temperature on cardiovascular outcomes. Material and Methods: This study was carried out based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Papers about the ambient temperature and cardiovascular outcomes were searched in the scientific database, including ISI, PubMed, Scopus, and Google Scholar, from January 1970 up to the end of 2020. We used the key terms, such as “heat wave”, “cold wave”, “extreme event”, “cardiovascular disease”, “mortality”, and “morbidity”. The thematic analysis method was used to determine all themes and analyze the data. Results: Among the 7631 searched and extracted papers, 20 articles met the eligibility criteria for including the process of final analysis. Effects of extreme events included mortality, morbidity, and hospitalization due to CVD. A relationship between extreme events and CVD mortality was confirmed for cerebrovascular diseases, including congestive heart failure (CHF), ischemic heart diseases (IHD), myocardial infarction (MI), cardiac arrhythmia, coronary heart disease (CHD), out-of-hospital cardiac arrest (OHCA), acute coronary syndrome (ACS), and blood pressure. Conclusion: The present study indicated the impact of extreme ambient temperature on CVD outcomes. The findings provided adaptation and preventive measures and strategies which can be used for CVD patients and managers to prevent CVD due to ambient temperature.
导语:极端天气或气候,包括热浪和寒潮,被认为是一个健康问题,对健康造成不利影响,如心血管疾病(cvd)、死亡率和发病率。因此,本系统综述旨在研究极端环境温度对心血管结局的影响。材料和方法:本研究基于系统评价和荟萃分析首选报告项目(PRISMA)协议进行。从1970年1月至2020年底,在ISI、PubMed、Scopus和谷歌Scholar等科学数据库中检索了有关环境温度和心血管结局的论文。我们使用了关键术语,如“热浪”、“寒潮”、“极端事件”、“心血管疾病”、“死亡率”和“发病率”。采用主题分析法确定所有主题并对数据进行分析。结果:在7631篇检索提取的论文中,有20篇符合纳入终分析过程的资格标准。极端事件的影响包括心血管疾病导致的死亡率、发病率和住院率。在包括充血性心力衰竭(CHF)、缺血性心脏病(IHD)、心肌梗死(MI)、心律失常、冠心病(CHD)、院外心脏骤停(OHCA)、急性冠状动脉综合征(ACS)和血压在内的脑血管疾病中,极端事件与CVD死亡率之间存在关联。结论:本研究提示极端环境温度对心血管疾病预后的影响。研究结果可为CVD患者和管理者预防环境温度引起的CVD提供适应和预防措施和策略。
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引用次数: 3
Trend Analysis and Temporal and Spatial Distribution of Wet Bulb Globe Temperature as a Heat Stress Index in Iran during the Summer Season over a 30-year Period 伊朗近30年夏季湿球温度作为热应激指数的趋势分析及时空分布
Q4 Engineering Pub Date : 2021-12-28 DOI: 10.18502/jehsd.v6i4.8153
G. Fallah Ghalhari, S. Farhang Dehghan, Elham Akhlaghi Pirposhteh, M. Asghari
Introduction: Global warming is one of the most important environmental problems that have raised researchers’ attention. The present study aimed to analyze heat stress trends using the Wet Bulb Globe Temperature (WBGT) index in the country of Iran during the summer over a 30-year period. Materials and Methods: Daily summertime statistical data regarding mean temperature and mean relative humidity, taken from 40 synoptic meteorological stations across Iran during a 30-year period were obtained from the Iranian National Meteorological Department. The De Martonne climate classification system was used to categorize various climate regions of Iran. The WBGT index was calculated using the formula given by the Australian Bureau of Meteorology. The Mann-Kendall statistical test and the Sen's slope estimator were used to analyze the trends of the WBGT index. Results: The WBGT index had an upward trend during the three months of June, July, and August in 71.42%, 57.14%, and 66.66% of all stations and this trend was statistically significant in 53.32%, 50%, and 42.85% of those stations, respectively. Moreover, throughout the summer, 45% of the WBGT index measurements were in the medium range (18-23°C), 37.5% were in the high range (23-28°C), and 17.5% were in the very high range (> 28°C). Conclusion: The WBGT index followed an upward trend during the summer, especially in semi-arid regions of Iran. Considering the phenomenon of global warming, it is essential to monitor, plan ahead, and take necessary precaution measures for sensitive populations who are at high risk areas of the country.
引言:全球变暖是引起研究人员关注的最重要的环境问题之一。本研究旨在利用30年来伊朗夏季的全球湿球温度(WBGT)指数分析热应激趋势。资料与方法:伊朗国家气象部门提供伊朗全国40个天气气象站30年夏季平均气温和平均相对湿度的每日统计资料。用德马尔顿气候分类系统对伊朗的不同气候区进行了分类。WBGT指数是根据澳大利亚气象局给出的公式计算出来的。采用Mann-Kendall统计检验和Sen's斜率估计分析了WBGT指数的变化趋势。结果:6月、7月和8月WBGT指数分别有71.42%、57.14%和66.66%的站点呈上升趋势,其中分别有53.32%、50%和42.85%的站点呈显著上升趋势。此外,在整个夏季,45%的WBGT指数测量值处于中等范围(18-23°C), 37.5%处于高范围(23-28°C), 17.5%处于极高范围(10 -28°C)。结论:夏季WBGT指数呈上升趋势,特别是在伊朗半干旱区。考虑到全球变暖的现象,有必要对该国高风险地区的敏感人群进行监测、提前计划并采取必要的预防措施。
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引用次数: 1
The Effect of Wastewater Irrigation on the Activity of Soil Microorganisms 污水灌溉对土壤微生物活性的影响
Q4 Engineering Pub Date : 2021-09-25 DOI: 10.18502/jehsd.v6i3.7247
H. Karimi, M. Nikaeen, M. Hatamzadeh, M. V. Dastjerdi, Marzieh Farhadkhani
Introduction: The use of wastewater for irrigation in arid and semi-arid regions of the world is increasing. This study aimed to evaluate the effects of wastewater on the microbial activity of irrigated soils using the enzymatic activity of soil microorganisms. Materials and Methods: In this study, for soil irrigation, the secondary effluent of the Isfahan municipal wastewater treatment plant was used. As a control, tap water that has no microbial load was also used. Soil samples were collected in two stages, before and immediately after irrigation. All samples were collected in sterile bags, transferred immediately to the laboratory for physicochemical and microbiological tests. Soil samples were analyzed for the amounts of enzymatic activity (Fluorescein Diacetate (FDA) and dehydrogenase), electrical conductivity (EC), oxidation-reduction potential (ORP), and pH. Results: The EC levels before and after irrigation with tap water was 231.2 and 260.63 µs.cm-1, respectively, which was significantly different from levels of wastewater-irrigated soil (P < 0.05).  pH in the two types of used water before and after irrigation was 6-8 and 7-8, respectively. No significant difference was observed in the levels of FDA, dehydrogenase, ORP, and microbial population in samples irrigated with water and wastewaters (p > 0.05). It was found that there is a significant relationship between bacterial density and FDA (P < 0.05). Conclusion: The results of the study showed that irrigation with wastewater has no significant effect on the microbial activity of irrigated soil. Because of the short-term wastewater irrigation in the present study, however, further investigation is needed to evaluate the effect of long-term wastewater irrigation on the microbial and physicochemical quality of soil.
引言:在世界干旱和半干旱地区,废水灌溉的使用正在增加。本研究旨在利用土壤微生物酶活性评价废水对灌溉土壤微生物活性的影响。材料与方法:本研究采用伊斯法罕城市污水处理厂的二级出水进行土壤灌溉。作为对照,也使用了没有微生物负荷的自来水。土壤样品采集分为灌溉前和灌溉后两个阶段。所有样品均装在无菌袋中收集,立即送往实验室进行理化和微生物试验。分析土壤样品的酶活性(双醋酸荧光素(FDA)和脱氢酶)、电导率(EC)、氧化还原电位(ORP)和ph值。结果:自来水灌溉前后的EC水平分别为231.2µs和260.63µs。cm-1,与废水灌溉土壤水平差异显著(P < 0.05)。两类废水灌溉前后pH值分别为6-8和7-8。经水和废水灌溉的样品中FDA、脱氢酶、ORP和微生物数量无显著差异(p < 0.05)。结果发现,细菌密度与FDA呈显著相关(P < 0.05)。结论:研究结果表明,废水灌溉对灌溉土壤微生物活性无显著影响。然而,由于本研究采用的是短期灌溉,长期灌溉对土壤微生物质量和理化质量的影响还有待进一步研究。
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引用次数: 0
Education for Sustainable Development (ESD) in Iran 伊朗可持续发展教育(ESD)
Q4 Engineering Pub Date : 2021-09-10 DOI: 10.18502/jehsd.v6i3.7240
Soheila Bazm
The article's abstract is not available.  
这篇文章的摘要没有。
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引用次数: 1
The Relationship between Blood Type and Cutaneous Leishmaniasis in Iran (A Review) 伊朗皮肤利什曼病与血型的关系(综述)
Q4 Engineering Pub Date : 2021-09-10 DOI: 10.18502/jehsd.v6i3.7241
M. Arani, M. Abedzadeh, Mehnoosh Nasiri, Mahdiyeh Mohammadzadeh
Introduction: Cutaneous leishmaniasis is one of the health concerns in Iran. Numerous studies have examined the role of blood type in people with the disease. Therefore, this study aimed to investigate the prevalence of leishmaniasis in different blood groups as a review in Iran. Materials and Methods: For this review, two researchers evaluated the extracted articles in terms of relevance to the purpose of the study after searching four databases, including Scopus, Web of Science, PubMed, and Science Direct. Literature reports on the prevalence of leishmaniasis in different blood groups in Iran until the end of March 2021. Relevant information included study time, study tool, number of subjects, mean age, and the relationship between blood type and infection which were recorded in Excel form. Results: After searching, screening, and qualitative evaluation of the studies, out of 135 identified articles, five papers met the required requirements. These five articles were published from 1999 to 2012, three studies examined the relationship between cutaneous leishmaniasis with different age groups. Also, three studies experimentally evaluated the relationship between cutaneous leishmaniasis with different human blood groups. Conclusion: According to the results of the present review, cutaneous leishmaniasis is more common in some blood groups. Studies have shown that Rh-negative blood groups with B alleles are more affected by cutaneous leishmaniasis than others; however, more studies are required.
引言:皮肤利什曼病是伊朗的健康问题之一。许多研究已经检验了血型在该疾病患者中的作用。因此,本研究旨在调查利什曼病在伊朗不同血型中的流行情况。材料和方法:在这篇综述中,两名研究人员在搜索了Scopus、Web of Science、PubMed和Science Direct四个数据库后,根据与研究目的的相关性对提取的文章进行了评估。截至2021年3月底,伊朗不同血型利什曼病流行率的文献报告。相关信息包括研究时间、研究工具、受试者人数、平均年龄以及血型与感染之间的关系,并记录在Excel表格中。结果:经过搜索、筛选和定性评估,在135篇已鉴定的文章中,有5篇符合要求。这五篇文章发表于1999年至2012年,三项研究考察了不同年龄组皮肤利什曼病之间的关系。此外,三项研究通过实验评估了皮肤利什曼病与不同人类血型之间的关系。结论:根据本综述的结果,皮肤利什曼病在某些血型中更常见。研究表明,具有B等位基因的Rh阴性血型比其他血型更容易受到皮肤利什曼病的影响;然而,还需要更多的研究。
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引用次数: 0
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