Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-6-21-32
T. Vakhitov, S. Kononova, E. Demyanova, A. S. Morugina, V. A. Utsal, M. I. Skalinskaya, I. Bakulin, A. Khavkin, Stanislav Sitkin
Objective. To identify candidate biomarkers for inflammatory bowel disease (IBD) using non-targeted serum metabolomics in patients with ulcerative colitis (UC). Patients and methods. This pilot study included 9 male patients with active UC and 11 healthy male controls. Serum metabolomic analysis was carried out by gas chromatography-mass spectrometry (GC-MS). Compounds were identified using the NIST08 mass spectral library. Classification of samples and search for candidate biomarkers were performed using a support vector machine (SVM), projections to latent structures-discriminant analysis (PLS-DA), and a naive Bayes classifier (Naïve Bayes). When choosing a classifier, we were guided by the areas under the ROC curve. Results. Metabolomic analysis revealed 85 compounds, of which 79 were annotated. The normalized serum levels of 14 metabolites (2-hydroxybutyric acid, caprylic acid, erythronic acid, creatinine, β-glycerophosphate, α-glycerophosphate, 2-keto-D-gluconic acid, pentadecanoic acid, trans-palmitoleic acid, palmitic acid, margaric acid, palmitoleic acid, squalene, α-tocopherol) differed significantly between the groups. Serum levels of all these compounds (except α-tocopherol) were elevated in UC patients compared to healthy controls, which was accompanied by an increase in the concentration scatter. The largest area under the ROC curve corresponded to the Naïve Bayes classifier (AUC = 0.931; excellent model quality). Conclusion. The study identified 14 metabolites that can be used as candidate biomarkers for IBD after proper verification, both for diagnosis and for assessment of the efficacy of therapy. The identification of disease-associated metabolites will facilitate the development of novel biotherapeutics. Key words: inflammatory bowel disease, ulcerative colitis, metabolome, biomarkers, gas chromatography-mass spectrometry.
目标。在溃疡性结肠炎(UC)患者中使用非靶向血清代谢组学鉴定炎症性肠病(IBD)的候选生物标志物。患者和方法。这项初步研究包括9名男性活动性UC患者和11名健康男性对照。血清代谢组学分析采用气相色谱-质谱联用(GC-MS)。化合物通过NIST08质谱库进行鉴定。使用支持向量机(SVM)、潜在结构判别分析(PLS-DA)和朴素贝叶斯分类器(Naïve Bayes)对样本进行分类和候选生物标志物的搜索。在选择分类器时，我们以ROC曲线下的面积为指导。结果。代谢组学分析发现85个化合物，其中79个被注释。14种代谢物(2-羟基丁酸、辛酸、赤藓酸、肌酐、β-甘油磷酸、α-甘油磷酸、2-酮- d -葡萄糖酸、戊酸、反式棕榈油酸、棕榈酸、人造黄油酸、棕榈油酸、角鲨烯、α-生育酚)的标准化血清水平在两组间差异显著。与健康对照组相比，UC患者血清中所有这些化合物(α-生育酚除外)的水平均升高，并伴有浓度散点的增加。ROC曲线下面积最大的是Naïve贝叶斯分类器(AUC = 0.931;优秀的模型质量)。结论。该研究确定了14种代谢物，经过适当的验证，可作为IBD的候选生物标志物，用于诊断和评估治疗效果。疾病相关代谢物的鉴定将促进新型生物疗法的发展。关键词:炎症性肠病，溃疡性结肠炎，代谢组，生物标志物，气相色谱-质谱法
{"title":"Identification of candidate biomarkers for inflammatory bowel disease using non-targeted serum metabolomics","authors":"T. Vakhitov, S. Kononova, E. Demyanova, A. S. Morugina, V. A. Utsal, M. I. Skalinskaya, I. Bakulin, A. Khavkin, Stanislav Sitkin","doi":"10.20953/1727-5784-2022-6-21-32","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-6-21-32","url":null,"abstract":"Objective. To identify candidate biomarkers for inflammatory bowel disease (IBD) using non-targeted serum metabolomics in patients with ulcerative colitis (UC). Patients and methods. This pilot study included 9 male patients with active UC and 11 healthy male controls. Serum metabolomic analysis was carried out by gas chromatography-mass spectrometry (GC-MS). Compounds were identified using the NIST08 mass spectral library. Classification of samples and search for candidate biomarkers were performed using a support vector machine (SVM), projections to latent structures-discriminant analysis (PLS-DA), and a naive Bayes classifier (Naïve Bayes). When choosing a classifier, we were guided by the areas under the ROC curve. Results. Metabolomic analysis revealed 85 compounds, of which 79 were annotated. The normalized serum levels of 14 metabolites (2-hydroxybutyric acid, caprylic acid, erythronic acid, creatinine, β-glycerophosphate, α-glycerophosphate, 2-keto-D-gluconic acid, pentadecanoic acid, trans-palmitoleic acid, palmitic acid, margaric acid, palmitoleic acid, squalene, α-tocopherol) differed significantly between the groups. Serum levels of all these compounds (except α-tocopherol) were elevated in UC patients compared to healthy controls, which was accompanied by an increase in the concentration scatter. The largest area under the ROC curve corresponded to the Naïve Bayes classifier (AUC = 0.931; excellent model quality). Conclusion. The study identified 14 metabolites that can be used as candidate biomarkers for IBD after proper verification, both for diagnosis and for assessment of the efficacy of therapy. The identification of disease-associated metabolites will facilitate the development of novel biotherapeutics. Key words: inflammatory bowel disease, ulcerative colitis, metabolome, biomarkers, gas chromatography-mass spectrometry.","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67717083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-6-51-62
A. Zavyalova, V. Novikova, M.V. Gavshchyuk, Yu. V. Kuznetsova
Dysphagia is a secondary symptom representing any disruption in the swallowing process. There are two main types of dysphagia: oropharyngeal and esophageal. Oropharyngeal dysphagia accounts for about 80–85% of all swallowing problems. In patients with mild to moderate dysphagia, oral feeding with thickening agents is available. This review provides options for testing various thickeners used for both diagnostic and therapeutic purposes, as well as for food modification. A stepwise choice of food texture for patients of different ages depending on the severity of dysphagia is presented. Key words: dysphagia, diet therapy, thickeners, food texture
{"title":"Dysphagia: diagnosis, modern methods of diet therapy","authors":"A. Zavyalova, V. Novikova, M.V. Gavshchyuk, Yu. V. Kuznetsova","doi":"10.20953/1727-5784-2022-6-51-62","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-6-51-62","url":null,"abstract":"Dysphagia is a secondary symptom representing any disruption in the swallowing process. There are two main types of dysphagia: oropharyngeal and esophageal. Oropharyngeal dysphagia accounts for about 80–85% of all swallowing problems. In patients with mild to moderate dysphagia, oral feeding with thickening agents is available. This review provides options for testing various thickeners used for both diagnostic and therapeutic purposes, as well as for food modification. A stepwise choice of food texture for patients of different ages depending on the severity of dysphagia is presented. Key words: dysphagia, diet therapy, thickeners, food texture","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67716824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/2224-5448-2022-4-5-10
Y. Chekhonina, K. M. Gapparova, I. Vorozhko, A. A. Sokolnikov
Patients and methods. This study included 43 elderly patients with class I-III obesity, who were randomized into two groups: the study group (24 patients) and the comparison group (19 patients). Anthropometric and serum parameters were assessed in all patients before and after diet therapy: total protein, transaminases, triglycerides, cholesterol fractions, glucose, uric acid, potassium, calcium, magnesium, iron, vitamins A, B2, B6, B9, B12, E, C and 25(OH)D3. Patients in the study group received a modified version of the standard diet with calorie restriction up to 1700 kcal and with protein modification by including 36 g of a specialized product for 14 days. Patients in the comparison group received a variation of the standard diet with calorie restriction up to 1730 kcal. Results. In patients in the study group, there were positive dynamics of biochemical parameters (a significant decrease in the levels of total cholesterol, glucose, uric acid, an increase in serum concentrations of 25(OH) D3, vitamin E and B12, potassium, calcium, magnesium, and zinc) and body composition parameters (a significant reduction of fat mass, total fluid, a slight increase in muscle mass) against the background of diet therapy with the inclusion of a specialized food product. Conclusion. Thus, timely diagnosis and correction of eating disorders in the elderly is an important part of the prevention and rehabilitation of alimentary-dependent diseases. Key words: obesity, diet therapy, elderly
{"title":"Evaluation of the effectiveness of diet therapy with protein modification in elderly patients with obesity","authors":"Y. Chekhonina, K. M. Gapparova, I. Vorozhko, A. A. Sokolnikov","doi":"10.20953/2224-5448-2022-4-5-10","DOIUrl":"https://doi.org/10.20953/2224-5448-2022-4-5-10","url":null,"abstract":"Patients and methods. This study included 43 elderly patients with class I-III obesity, who were randomized into two groups: the study group (24 patients) and the comparison group (19 patients). Anthropometric and serum parameters were assessed in all patients before and after diet therapy: total protein, transaminases, triglycerides, cholesterol fractions, glucose, uric acid, potassium, calcium, magnesium, iron, vitamins A, B2, B6, B9, B12, E, C and 25(OH)D3. Patients in the study group received a modified version of the standard diet with calorie restriction up to 1700 kcal and with protein modification by including 36 g of a specialized product for 14 days. Patients in the comparison group received a variation of the standard diet with calorie restriction up to 1730 kcal. Results. In patients in the study group, there were positive dynamics of biochemical parameters (a significant decrease in the levels of total cholesterol, glucose, uric acid, an increase in serum concentrations of 25(OH) D3, vitamin E and B12, potassium, calcium, magnesium, and zinc) and body composition parameters (a significant reduction of fat mass, total fluid, a slight increase in muscle mass) against the background of diet therapy with the inclusion of a specialized food product. Conclusion. Thus, timely diagnosis and correction of eating disorders in the elderly is an important part of the prevention and rehabilitation of alimentary-dependent diseases. Key words: obesity, diet therapy, elderly","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76386337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-3-12-19
A. Kolchina, O. Khaletskaya, V. N. Borisova
Objective. To evaluate the efficacy of a low-protein diet (LPD) in patients with secondary hyperammonemia (HA) during the period of clinical manifestation depending on its etiology and the level of ammonia, and to substantiate management tactics. Patients and methods. This study included 29 patients with secondary HA. Patients were divided into two age groups depending on the onset of HA: the neonatal group (group 1; n = 15) and the infant and toddler group (group 2; n = 14). Depending on the causes of HA, two subgroups were identified: patients with HA associated with inherited metabolic diseases (IMD) and patients with HA not associated with IMD. Results. In group 1, 5 patients with mild transient HA (THA) (116.4 [106.9–136.9] μmol/L) did not receive LPD, and HA resolved within a week. Of the remaining 10 patients, five had a positive response to LPD (patients with IMD and THA). HA was severe (1588.5 [1315.0–1862.0] μmol/L), and the normalization of parameters was noted by day 14 [9–19]. Another 5 patients had a wave-like character of HA against the background of LPD (p = 0.350). In group 2, 10 patients with mild HA (87.45 [75.25–107.6] μmol/L) were not treated with LPD, all of them belonged to subgroup 2, and the normalization of parameters was observed on day 4. Another 4 patients with moderate HA (219.15 [188.85–245.6] μmol/L) received LPD, HA had a wave-like character (patients with IMD and HA not associated with IMD). Conclusion. The study showed that the course of HA against the background of LPD varies depending on patient age, disease severity and etiology. Key words: hyperammonemia, newborns, metabolic crisis, inherited metabolic diseases, low-protein diet, valproic acid
{"title":"Efficacy of low-protein diet in children with secondary hyperammonemia of different etiologies","authors":"A. Kolchina, O. Khaletskaya, V. N. Borisova","doi":"10.20953/1727-5784-2022-3-12-19","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-3-12-19","url":null,"abstract":"Objective. To evaluate the efficacy of a low-protein diet (LPD) in patients with secondary hyperammonemia (HA) during the period of clinical manifestation depending on its etiology and the level of ammonia, and to substantiate management tactics. Patients and methods. This study included 29 patients with secondary HA. Patients were divided into two age groups depending on the onset of HA: the neonatal group (group 1; n = 15) and the infant and toddler group (group 2; n = 14). Depending on the causes of HA, two subgroups were identified: patients with HA associated with inherited metabolic diseases (IMD) and patients with HA not associated with IMD. Results. In group 1, 5 patients with mild transient HA (THA) (116.4 [106.9–136.9] μmol/L) did not receive LPD, and HA resolved within a week. Of the remaining 10 patients, five had a positive response to LPD (patients with IMD and THA). HA was severe (1588.5 [1315.0–1862.0] μmol/L), and the normalization of parameters was noted by day 14 [9–19]. Another 5 patients had a wave-like character of HA against the background of LPD (p = 0.350). In group 2, 10 patients with mild HA (87.45 [75.25–107.6] μmol/L) were not treated with LPD, all of them belonged to subgroup 2, and the normalization of parameters was observed on day 4. Another 4 patients with moderate HA (219.15 [188.85–245.6] μmol/L) received LPD, HA had a wave-like character (patients with IMD and HA not associated with IMD). Conclusion. The study showed that the course of HA against the background of LPD varies depending on patient age, disease severity and etiology. Key words: hyperammonemia, newborns, metabolic crisis, inherited metabolic diseases, low-protein diet, valproic acid","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67715777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-1-52-57
O. Netrebenko, P. Shumilov
A close connection between the immune system and metabolism has been identified in many experimental and clinical studies. The cells of the immune system have the highest energy requirements due to active proliferation, while they have no depot of energy storage and plastics and depend on their ingestion from outside. The phenotype and functional activity of immune cells directly depend on the type of their energy supply. Overnutrition or malnutrition, deficiency of certain micronutrients, and intestinal metabolic activity significantly affect immune cell function. Modulation of basic metabolic and signaling pathways has a considerable impact on the proliferation, differentiation, and functional activity of T cells. Metabolic targeted therapy for immune cells is a promising type of treatment for immune-mediated and cancer diseases. Key words: immunometabolism, metabolism, T cells, inflammation, cancer, treatment
{"title":"Immunometabolism: new perspectives for the treatment of immune-mediated diseases","authors":"O. Netrebenko, P. Shumilov","doi":"10.20953/1727-5784-2022-1-52-57","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-1-52-57","url":null,"abstract":"A close connection between the immune system and metabolism has been identified in many experimental and clinical studies. The cells of the immune system have the highest energy requirements due to active proliferation, while they have no depot of energy storage and plastics and depend on their ingestion from outside. The phenotype and functional activity of immune cells directly depend on the type of their energy supply. Overnutrition or malnutrition, deficiency of certain micronutrients, and intestinal metabolic activity significantly affect immune cell function. Modulation of basic metabolic and signaling pathways has a considerable impact on the proliferation, differentiation, and functional activity of T cells. Metabolic targeted therapy for immune cells is a promising type of treatment for immune-mediated and cancer diseases. Key words: immunometabolism, metabolism, T cells, inflammation, cancer, treatment","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67715129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-5-16-26
S. Makarova, E. E. Emelyashenkov, A. Fisenko, N. Murashkin, M. Vershinina, E. Semikina, D. S. Yasakov, M. Snovskaya, O. Ereshko, A. Galimova
Objective. To assess the nutritional status and factors affecting it in children with severe atopic dermatitis (AD) and food allergy (FA). Patients and methods. This single-center, observational, cross-sectional, uncontrolled, retrospective study enrolled 315 children aged between 1 month and 17 years 11 months with severe AD and FA. Standard anthropometric parameters were measured and calculated, including WAZ (weight-for-age Z-score), HAZ (height-for-age Z-score), and BAZ (BMI-for-age Z-score). Patients’ medical histories were examined, and the levels of total IgE and specific IgE to food allergens, hemoglobin, ferritin, iron, and vitamin D were evaluated. Results. On average, anthr opometric parameters in the examined patients were below the reference values. Failure to thrive of mild degree was detected in 27.6% of children, moderate degree in 13.7%, and severe degree in 2,2%. The frequency of overweight and obesity was 9.5% and 3.8%, respectively. A correlation was found between HAZ and children’s age (r = 0.21, p = 0.015) and the number of excluded food groups (r = -1.66, p = 0.031), and between BAZ and the number of excluded food groups (r = -1.39, p = 0.019). HAZ (p = 0.014) and BAZ (p = 0.017) values were lower in children following a dairy-free diet than in children on other types of elimination diets. At the same time, BAZ was higher in children who did not strictly follow the diet than in those who did (p = 0.011). There was a correlation between BAZ and vitamin D levels (r = 0.29, p = 0.012). Formulas based on extensive hydrolyzed protein and free aminoacides reduced severity and frequency of failure to thrive in management children with CMPA. Conclusion. Children with severe AD and FA require careful planning of their diets to reduce the risk of failure to thrive. It is necessary to study the influence of dietary composition and eating behavior of patients on their nutritional status. Key words: children, atopic dermatitis, nutritional status, elimination diet, food allergy, physical development, vitamin D
目标。探讨严重特应性皮炎(AD)和食物过敏(FA)患儿的营养状况及其影响因素。患者和方法。这项单中心、观察性、横断面、非对照、回顾性研究招募了315名患有严重AD和FA的儿童，年龄在1个月至17岁11个月之间。测量和计算标准人体测量参数，包括WAZ(体重年龄z分数)、HAZ(身高年龄z分数)和BAZ (bmi年龄z分数)。检查患者的病史，评估总IgE和对食物过敏原、血红蛋白、铁蛋白、铁和维生素D的特异性IgE水平。结果。平均而言，检查患者的验光参数低于参考值。轻度发育不良患儿占27.6%，中度发育不良患儿占13.7%，重度发育不良患儿占2.2%。超重和肥胖的频率分别为9.5%和3.8%。HAZ与儿童年龄(r = 0.21, p = 0.015)、被排除食物组数(r = -1.66, p = 0.031)、BAZ与被排除食物组数(r = -1.39, p = 0.019)呈正相关。无乳制品饮食的儿童HAZ (p = 0.014)和BAZ (p = 0.017)值低于其他类型消除饮食的儿童。与此同时，未严格遵循饮食的儿童的BAZ高于严格遵循饮食的儿童(p = 0.011)。BAZ与维生素D水平存在相关性(r = 0.29, p = 0.012)。基于广泛水解蛋白和游离氨基酸的配方降低了CMPA患儿生长失败的严重程度和频率。结论。患有严重AD和FA的儿童需要仔细规划他们的饮食，以减少无法茁壮成长的风险。因此，有必要研究患者饮食组成和饮食行为对其营养状况的影响。关键词:儿童，特应性皮炎，营养状况，消除饮食，食物过敏，身体发育，维生素D
{"title":"Anthropometric parameters and nutritional status in children with severe atopic dermatitis and food allergy","authors":"S. Makarova, E. E. Emelyashenkov, A. Fisenko, N. Murashkin, M. Vershinina, E. Semikina, D. S. Yasakov, M. Snovskaya, O. Ereshko, A. Galimova","doi":"10.20953/1727-5784-2022-5-16-26","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-5-16-26","url":null,"abstract":"Objective. To assess the nutritional status and factors affecting it in children with severe atopic dermatitis (AD) and food allergy (FA). Patients and methods. This single-center, observational, cross-sectional, uncontrolled, retrospective study enrolled 315 children aged between 1 month and 17 years 11 months with severe AD and FA. Standard anthropometric parameters were measured and calculated, including WAZ (weight-for-age Z-score), HAZ (height-for-age Z-score), and BAZ (BMI-for-age Z-score). Patients’ medical histories were examined, and the levels of total IgE and specific IgE to food allergens, hemoglobin, ferritin, iron, and vitamin D were evaluated. Results. On average, anthr opometric parameters in the examined patients were below the reference values. Failure to thrive of mild degree was detected in 27.6% of children, moderate degree in 13.7%, and severe degree in 2,2%. The frequency of overweight and obesity was 9.5% and 3.8%, respectively. A correlation was found between HAZ and children’s age (r = 0.21, p = 0.015) and the number of excluded food groups (r = -1.66, p = 0.031), and between BAZ and the number of excluded food groups (r = -1.39, p = 0.019). HAZ (p = 0.014) and BAZ (p = 0.017) values were lower in children following a dairy-free diet than in children on other types of elimination diets. At the same time, BAZ was higher in children who did not strictly follow the diet than in those who did (p = 0.011). There was a correlation between BAZ and vitamin D levels (r = 0.29, p = 0.012). Formulas based on extensive hydrolyzed protein and free aminoacides reduced severity and frequency of failure to thrive in management children with CMPA. Conclusion. Children with severe AD and FA require careful planning of their diets to reduce the risk of failure to thrive. It is necessary to study the influence of dietary composition and eating behavior of patients on their nutritional status. Key words: children, atopic dermatitis, nutritional status, elimination diet, food allergy, physical development, vitamin D","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67716406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-2-29-37
N. D. Odinaeva, E. Kondratyeva, E. Loshkova, I. Osmanov, A. Khavkin, I. Zakharova, Yu. F. Shubina, E. Pasnova, Yu.B. Ponomarenko
Objective. To assess serum 25(OH)D levels in patients with various diseases living in Moscow and the Moscow region, considering the season of the year and age. Patients and methods. A cross-sectional uncontrolled diagnostic trial was performed. It included 10.707 people: 8,441 (78.8%) women and 2,266 (21.2%) men; children accounted for 15% (1,501 children) and adults – for 85% (9,206 people); the mean age of adults was 49.86 ± 21.92 years and that of children – 13.45 ± 11.76 years. Results. The maximum prevalence of severe 25(OH)D deficiency was revealed among patients with neoplasms (48.9%); patients with diseases of the musculoskeletal system and connective tissue had severe 25(OH)D deficiency in 16.9% of cases, with urogenital diseases – in 19.6% of cases, with digestive diseases – in 19.0% of cases, with perinatal diseases – in 15.7% of cases, with diseases of blood and hematopoietic organs – in 22.3% of cases, which proved to be 2-3 times more frequent compared to individuals with diseases of other classes. Individuals who underwent preventive examination had the lowest prevalence (1.4%) of severe 25(OH)D deficiency. In case of diseases with chronic progressive autoimmune inflammation (type 1 diabetes mellitus (DM), rheumatoid arthritis (RA)), neoplasms, as well as in complications of diseases of various pathogenesis, such as chronic kidney disease (CKD), vitamin D deficiency was observed throughout the year, which did not correspond to increasing daylight hours. Children with perinatal diseases and born preterm had low levels and severe deficiency of 25(OH)D, which occurred immediately after birth. Conclusion. The prevalence of vitamin D deficiency was 82.9%; the lowest serum 25(OH)D levels were recorded in winter and spring. Severe year-round serum 25(OH)D deficiency was revealed in patients with autoimmune diseases and chronic kidney disease. Key words: adults, vitamin D, inflammation, 25(OH)D, children, deficiency, seasons of the year
{"title":"Seasonal variations in serum vitamin D levels in children and adults with various diseases","authors":"N. D. Odinaeva, E. Kondratyeva, E. Loshkova, I. Osmanov, A. Khavkin, I. Zakharova, Yu. F. Shubina, E. Pasnova, Yu.B. Ponomarenko","doi":"10.20953/1727-5784-2022-2-29-37","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-2-29-37","url":null,"abstract":"Objective. To assess serum 25(OH)D levels in patients with various diseases living in Moscow and the Moscow region, considering the season of the year and age. Patients and methods. A cross-sectional uncontrolled diagnostic trial was performed. It included 10.707 people: 8,441 (78.8%) women and 2,266 (21.2%) men; children accounted for 15% (1,501 children) and adults – for 85% (9,206 people); the mean age of adults was 49.86 ± 21.92 years and that of children – 13.45 ± 11.76 years. Results. The maximum prevalence of severe 25(OH)D deficiency was revealed among patients with neoplasms (48.9%); patients with diseases of the musculoskeletal system and connective tissue had severe 25(OH)D deficiency in 16.9% of cases, with urogenital diseases – in 19.6% of cases, with digestive diseases – in 19.0% of cases, with perinatal diseases – in 15.7% of cases, with diseases of blood and hematopoietic organs – in 22.3% of cases, which proved to be 2-3 times more frequent compared to individuals with diseases of other classes. Individuals who underwent preventive examination had the lowest prevalence (1.4%) of severe 25(OH)D deficiency. In case of diseases with chronic progressive autoimmune inflammation (type 1 diabetes mellitus (DM), rheumatoid arthritis (RA)), neoplasms, as well as in complications of diseases of various pathogenesis, such as chronic kidney disease (CKD), vitamin D deficiency was observed throughout the year, which did not correspond to increasing daylight hours. Children with perinatal diseases and born preterm had low levels and severe deficiency of 25(OH)D, which occurred immediately after birth. Conclusion. The prevalence of vitamin D deficiency was 82.9%; the lowest serum 25(OH)D levels were recorded in winter and spring. Severe year-round serum 25(OH)D deficiency was revealed in patients with autoimmune diseases and chronic kidney disease. Key words: adults, vitamin D, inflammation, 25(OH)D, children, deficiency, seasons of the year","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67715239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-2-38-44
A. Paraskevova, A. Trukhmanov, O. Storonova, A. B. Ponomarev, V. Ivashkin
Objective. To study the immune response and esophageal motility in patients with non-erosive reflux disease (NERD), gastroesophageal reflux disease (GERD) complicated by intestinal-type cylindrical cell metaplasia (CCM), and Barrett’s esophagus (BE). Patients and methods. The study included 30 patients: 10 patients with NERD, 10 patients with GERD complicated by intestinaltype CCM, and 10 patients with BE. All patients underwent high-resolution esophageal manometry. The expression levels of surface receptors CD25, CD80 (Th1-type immune response) and CD163, CD206 (Th2-type immune response) were analyzed. Results. The analysis revealed high CD206 expression in patients with NERD and GERD complicated by intestinal-type CCM compared to BE (р = 0.011, р = 0.075, respectively). In patients with NERD, median distal contractile integral (DCI) was 920 [178; 2033] mmHg⋅s⋅cm; in patients with GERD complicated by intestinal-type CCM, it was 1046 [223; 3759] mmHg⋅s⋅cm; in patients with BE – 276 [1; 1870] mmHg⋅s⋅cm. Patients with BE had ineffective esophageal motility more often than patients with NERD and GERD complicated by intestinal-type CCM (р = 0.06, р = 0.052, respectively). Lower esophageal sphincter pressure was 22.5 [8; 40] mmHg in patients with NERD, 18.0 [7.0; 36.0] mmHg in patients with GERD complicated by intestinal-type CCM, and 14.5 [1.0; 30.0] mmHg in patients with BE. The positive correlation between high CD206 expression and DCI (r = 0.317, р = 0.077) was determined. Conclusion. The role of esophageal motility disorder and immune response in patients with GERD should be further studied to assess their impact on the course of the disease. Key words: gastroesophageal reflux disease, immune response, high-resolution esophageal manometry, metaplasia
{"title":"Esophageal motility disorder and high CD206 expression in patients with gastroesophageal reflux disease","authors":"A. Paraskevova, A. Trukhmanov, O. Storonova, A. B. Ponomarev, V. Ivashkin","doi":"10.20953/1727-5784-2022-2-38-44","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-2-38-44","url":null,"abstract":"Objective. To study the immune response and esophageal motility in patients with non-erosive reflux disease (NERD), gastroesophageal reflux disease (GERD) complicated by intestinal-type cylindrical cell metaplasia (CCM), and Barrett’s esophagus (BE). Patients and methods. The study included 30 patients: 10 patients with NERD, 10 patients with GERD complicated by intestinaltype CCM, and 10 patients with BE. All patients underwent high-resolution esophageal manometry. The expression levels of surface receptors CD25, CD80 (Th1-type immune response) and CD163, CD206 (Th2-type immune response) were analyzed. Results. The analysis revealed high CD206 expression in patients with NERD and GERD complicated by intestinal-type CCM compared to BE (р = 0.011, р = 0.075, respectively). In patients with NERD, median distal contractile integral (DCI) was 920 [178; 2033] mmHg⋅s⋅cm; in patients with GERD complicated by intestinal-type CCM, it was 1046 [223; 3759] mmHg⋅s⋅cm; in patients with BE – 276 [1; 1870] mmHg⋅s⋅cm. Patients with BE had ineffective esophageal motility more often than patients with NERD and GERD complicated by intestinal-type CCM (р = 0.06, р = 0.052, respectively). Lower esophageal sphincter pressure was 22.5 [8; 40] mmHg in patients with NERD, 18.0 [7.0; 36.0] mmHg in patients with GERD complicated by intestinal-type CCM, and 14.5 [1.0; 30.0] mmHg in patients with BE. The positive correlation between high CD206 expression and DCI (r = 0.317, р = 0.077) was determined. Conclusion. The role of esophageal motility disorder and immune response in patients with GERD should be further studied to assess their impact on the course of the disease. Key words: gastroesophageal reflux disease, immune response, high-resolution esophageal manometry, metaplasia","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67715729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-3-67-74
M. Maradudin, I. Simakova, N. Bolotova, A. Fedonnikov
The aim of this research work was to study nutritional value of food beans for medical and biological justification of the possibility of combining it with wheat flour for the production of functional foods. The objects of the study were models of hearth bread made from: first grade wheat flour (100%), bean seed flour (white and red) (100%), as well as samples of hearth bread made from composite mixtures based on beans containing 50 and 75% of beans. Nutritional and biological value of the studied products was determined by calculation, comparing nutrient composition, protein digestibility amino acid score (corrected/uncorrected) and glycemic index. The authors found that nutrient composition and energy value of bread models based on bean flour (white and red beans) in terms of nutritional and energy value are superior to hearth wheat bread, including according to protein by 48, 73 and 97%, respectively, to the percentage of bean flour in hearth bread 50, 75 and 100%. The fat content in hearth bread when bean flour is added is reduced by 33, 47 and 62%, respectively, to the percentage of bean flour. At the same time, the amount of carbohydrates remains practically unchanged. The energy value of bread is increased due to the increase in the amount of protein in bean flour. Protein digestibility-corrected amino acid score (PDCAAS) of hearth bread is increased proportionally to the increase in the bean component by 1.95 times when adding 50% of flour, by 2.2 times – when adding 75% of flour, regardless of the type of beans. Adding beans to hearth bread significantly increases the content of calcium and magnesium – by 4 and 1.4–1.8 times, respectively. The glycemic index is decreased in proportion to the increase in the share of beans in hearth bread, while with a complete replacement of wheat flour with bean, the index is decreased by 2 times. Key words: bean flour, nutritional value, hearth bread, functional foods
{"title":"Nutritional value of beans in developing food products","authors":"M. Maradudin, I. Simakova, N. Bolotova, A. Fedonnikov","doi":"10.20953/1727-5784-2022-3-67-74","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-3-67-74","url":null,"abstract":"The aim of this research work was to study nutritional value of food beans for medical and biological justification of the possibility of combining it with wheat flour for the production of functional foods. The objects of the study were models of hearth bread made from: first grade wheat flour (100%), bean seed flour (white and red) (100%), as well as samples of hearth bread made from composite mixtures based on beans containing 50 and 75% of beans. Nutritional and biological value of the studied products was determined by calculation, comparing nutrient composition, protein digestibility amino acid score (corrected/uncorrected) and glycemic index. The authors found that nutrient composition and energy value of bread models based on bean flour (white and red beans) in terms of nutritional and energy value are superior to hearth wheat bread, including according to protein by 48, 73 and 97%, respectively, to the percentage of bean flour in hearth bread 50, 75 and 100%. The fat content in hearth bread when bean flour is added is reduced by 33, 47 and 62%, respectively, to the percentage of bean flour. At the same time, the amount of carbohydrates remains practically unchanged. The energy value of bread is increased due to the increase in the amount of protein in bean flour. Protein digestibility-corrected amino acid score (PDCAAS) of hearth bread is increased proportionally to the increase in the bean component by 1.95 times when adding 50% of flour, by 2.2 times – when adding 75% of flour, regardless of the type of beans. Adding beans to hearth bread significantly increases the content of calcium and magnesium – by 4 and 1.4–1.8 times, respectively. The glycemic index is decreased in proportion to the increase in the share of beans in hearth bread, while with a complete replacement of wheat flour with bean, the index is decreased by 2 times. Key words: bean flour, nutritional value, hearth bread, functional foods","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67716361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.20953/1727-5784-2022-6-64-70
A. Vashura, A.A. Pyataeva, A. F. Karelin
Children with malignant neoplasms are a high-risk group for developing nutritional and metabolic disorders, which are one of the key disabling factors that significantly reduce the effectiveness of medical and social rehabilitation. Dynamic monitoring, screening, and timely correction of identified problems, including nutritional ones, constitute an essential precondition for the success of rehabilitation. The basic principles of nutritional correction in pediatric oncology include the following: a personalized approach; avoidance of long intervals between meals; prescription of any restrictive diets only for reasonable indications; multidisciplinarity; sparing of the gastrointestinal tract; timely initiation of nutritional support; continuity, dynamic monitoring, and control of nutritional status. The aim of this study is to describe the main aspects of nutritional support in children with malignant neoplasms after the end of cancer treatment. Key words: children, nutritional support, oncology, nutrition, cancer
{"title":"Key aspects of nutrition and nutritional support for children with malignant neoplasms after completion of cancer treatment","authors":"A. Vashura, A.A. Pyataeva, A. F. Karelin","doi":"10.20953/1727-5784-2022-6-64-70","DOIUrl":"https://doi.org/10.20953/1727-5784-2022-6-64-70","url":null,"abstract":"Children with malignant neoplasms are a high-risk group for developing nutritional and metabolic disorders, which are one of the key disabling factors that significantly reduce the effectiveness of medical and social rehabilitation. Dynamic monitoring, screening, and timely correction of identified problems, including nutritional ones, constitute an essential precondition for the success of rehabilitation. The basic principles of nutritional correction in pediatric oncology include the following: a personalized approach; avoidance of long intervals between meals; prescription of any restrictive diets only for reasonable indications; multidisciplinarity; sparing of the gastrointestinal tract; timely initiation of nutritional support; continuity, dynamic monitoring, and control of nutritional status. The aim of this study is to describe the main aspects of nutritional support in children with malignant neoplasms after the end of cancer treatment. Key words: children, nutritional support, oncology, nutrition, cancer","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67716844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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