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Fast and reliable reduced-order models for cardiac electrophysiology
Q1 Mathematics Pub Date : 2024-01-03 DOI: 10.1002/gamm.202370014
Sridhar Chellappa, Barış Cansız, Lihong Feng, Peter Benner, Michael Kaliske

Mathematical models of the human heart increasingly play a vital role in understanding the working mechanisms of the heart, both under healthy functioning and during disease. The ultimate aim is to aid medical practitioners diagnose and treat the many ailments affecting the heart. Towards this, modeling cardiac electrophysiology is crucial as the heart's electrical activity underlies the contraction mechanism and the resulting pumping action. Apart from modeling attempts, the pursuit of efficient, reliable, and fast solution algorithms has been of great importance in this context. The governing equations and the constitutive laws describing the electrical activity in the heart are coupled, nonlinear, and involve a fast moving wave front, which is generally solved by the finite element method. The numerical treatment of this complex system as part of a virtual heart model is challenging due to the necessity of fine spatial and temporal resolution of the domain. Therefore, efficient surrogate models are needed to predict the electrical activity in the heart under varying parameters and inputs much faster than the finely resolved models. In this work, we develop an adaptive, projection-based reduced-order surrogate model for cardiac electrophysiology. We introduce an a posteriori error estimator that can accurately and efficiently quantify the accuracy of the surrogate model. Using the error estimator, we systematically update our surrogate model through a greedy search of the parameter space. Furthermore, using the error estimator, the parameter search space is dynamically updated such that the most relevant samples get chosen at every iteration. The proposed adaptive surrogate model is tested on three benchmark models to illustrate its efficiency, accuracy, and ability of generalization.

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引用次数: 0
Numerical evaluation of elasto-mechanical and visco-elastic electro-mechanical models of the human heart 人体心脏弹性机械模型和粘弹性电子机械模型的数值评估
Q1 Mathematics Pub Date : 2024-01-02 DOI: 10.1002/gamm.202370010
Jonathan Fröhlich, Tobias Gerach, Jonathan Krauß, Axel Loewe, Laura Stengel, Christian Wieners

We investigate the properties of static mechanical and dynamic electro-mechanical models for the deformation of the human heart. Numerically this is realized by a staggered scheme for the coupled partial/ordinary differential equation (PDE-ODE) system. First, we consider a static and purely mechanical benchmark configuration on a realistic geometry of the human ventricles. Using a penalty term for quasi-incompressibility, we test different parameters and mesh sizes and observe that this approach is not sufficient for lowest order conforming finite elements. Then, we compare the approaches of active stress and active strain for cardiac muscle contraction. Finally, we compare in a coupled anatomically realistic electro-mechanical model numerical Newmark damping with a visco-elastic model using Rayleigh damping. Nonphysiological oscillations can be better mitigated using viscosity.

我们研究了人体心脏变形的静态机械和动态电子机械模型的特性。在数值上,我们采用交错方案来实现耦合偏微分方程/常微分方程(PDE-ODE)系统。首先,我们在现实的人体心室几何图形上考虑了静态和纯机械基准配置。通过使用准不可压缩性惩罚项,我们测试了不同的参数和网格大小,发现这种方法对于最低阶符合有限元是不够的。然后,我们比较了用于心肌收缩的主动应力和主动应变方法。最后,我们比较了在耦合解剖现实机电模型中使用数值纽马克阻尼和使用瑞利阻尼的粘弹性模型。使用粘度可以更好地缓解非生理振荡。
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引用次数: 0
Optimal operation of dielectric elastomer wave energy converters under harmonic and stochastic excitation 介质弹性体波能转换器在谐波和随机激励下的优化运行
Q1 Mathematics Pub Date : 2023-05-25 DOI: 10.1002/gamm.202300010
Matthias K. Hoffmann, Lennart Heib, Giacomo Moretti, Gianluca Rizzello, Kathrin Flaßkamp

Dielectric elastomers are a promising technology for wave energy harvesting. An optimal system operation can allow maximizing the extracted energy and, simultaneously, reducing wear that would lead to a reduction in the wave harvester lifetime. We pursue a model-based optimization approach to identify optimal controls for wave energy harvesters based on dielectric elastomers. First, a direct method is used for time-discretization of the dielectric elastomer wave energy harvester in the optimal control problem. The two conflicting objectives are considered in a multiobjective optimization framework. Considering a periodic, sinusoidal wave excitation, the optimal solution shows turnpike properties for the optimal periodic mode of operation. However, since real wave motion is neither monochromatic nor predictable on longer time horizons, further extensions are pursued. First, we introduce a stochastic wave excitation. Second, an iterative model-predictive control scheme is designed. Due to multiple objectives, the control scheme has to include an automated adaption of the corresponding priorities. Here, we propose and evaluate a heuristic rule-based adaption in order to maintain the damage below target levels. The approach presented here might be used in the future to guarantee for autonomous operation of farms of wave energy harvesters.

介电弹性体是一种很有前途的波浪能收集技术。最佳的系统操作可以使提取的能量最大化,同时减少将导致波浪采集器寿命缩短的磨损。我们采用基于模型的优化方法来确定基于介电弹性体的波浪能采集器的最佳控制。首先,在最优控制问题中,采用直接方法对介质弹性体波能量采集器进行时间离散。在多目标优化框架中考虑了这两个相互冲突的目标。考虑到周期性正弦波激励,最优解显示了最佳周期性运行模式的收费公路特性。然而,由于真实的波浪运动在较长的时间范围内既不是单色的,也不是可预测的,因此需要进一步的扩展。首先,我们介绍了一种随机波激励。其次,设计了一种迭代模型预测控制方案。由于有多个目标,控制方案必须包括相应优先级的自动调整。在这里,我们提出并评估了一种启发式的基于规则的自适应,以将损伤保持在目标水平以下。本文提出的方法可能在未来用于保证波浪能采集器农场的自主运行。
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引用次数: 1
Preface to the topical issue on applied and nonlinear dynamics: Part II 应用动力学与非线性动力学专题前言:第二部分
Q1 Mathematics Pub Date : 2023-05-19 DOI: 10.1002/gamm.202300011
Jörg Fehr, Kristin de Payrebrune, Robert Seifried

The current special issue of the GAMM Mitteilungen, which is the second of a two-part series, contains several contributions on the topic of Applied and Nonlinear Dynamics. We are very happy that several teams of authors have accepted our invitation to report on recent developments, research highlights and emerging application areas in Applied and Nonlinear Dynamics.

This second part of the topical issue on Applied and Nonlinear Dynamics includes five interesting papers. These are devoted to numerical and experimental methods in applied and nonlinear dynamics as well as advanced applications of multibody systems and optimal control methods to dynamical systems.

Contribution 3 deals with stationary solutions in applied dynamics. Thereby a unified framework for the numerical calculation and stability assessment of periodic and quasi-periodic solutions based on invariant manifolds is presented. Paper 2 gives an overview of dynamic human body models in vehicle safety, a unique application of multibody dynamics. In paper 1, a family of total Lagrangian Petrov-Galerkin Cosserat rod finite element formulations is presented. Paper 5 discusses continuation methods for lab experiments of nonlinear vibrations. Finally paper 4 deals with the optimal operation of dielectric elastomer wave energy converters under harmonic and stochastic excitation.

GAMM Mitteilungen的当前特刊是由两部分组成的系列的第二期,包含了关于应用动力学和非线性动力学主题的几篇文章。我们很高兴有几个作者团队接受了我们的邀请,就应用和非线性动力学的最新发展、研究亮点和新兴应用领域进行报告。这是应用和非线性力学专题的第二部分,包括五篇有趣的论文。这些课程致力于应用动力学和非线性动力学中的数值和实验方法,以及多体系统和动力学系统最优控制方法的高级应用。贡献3涉及应用动力学中的平稳解。从而提出了基于不变流形的周期解和拟周期解的数值计算和稳定性评估的统一框架。论文2概述了动态人体模型在车辆安全中的应用,这是多体动力学的一个独特应用。在论文1中,提出了一类全拉格朗日Petrov-Galerkin-Cosserat杆有限元公式。论文5讨论了非线性振动实验室实验的延拓方法。最后,论文4讨论了介质弹性体波能转换器在谐波和随机激励下的优化运行。
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引用次数: 0
Continuation methods for lab experiments of nonlinear vibrations 非线性振动实验室实验的连续方法
Q1 Mathematics Pub Date : 2023-05-10 DOI: 10.1002/gamm.202300009
Sebastian Tatzko, Gleb Kleyman, Jörg Wallaschek

In this work, we will give an overview of our recent progress in experimental continuation. First, three different approaches are explained and compared which can be found in scientific papers on the topic. We then show S-Curve measurements of a Duffing oscillator experiment for which we derived optimal controller gains analytically. The derived formula for stabilizing PD-controller gains makes trial and error search for suitable values unnecessary. Since feedback control introduces higher harmonics in the driving signal, we consider a harmonization of the forcing signal. This harmonization is important to reduce shaker-structure interaction in the treatment of nonlinear frequency responses. Finally, the controlled nonlinear testing and harmonization is enhanced by a continuation algorithm adapted from numerical analysis and applied to a geometrically nonlinear beam test rig for which we measure the nonlinear forced response directly in the displacement-frequency plane.

在这项工作中,我们将概述我们在实验延续方面的最新进展。首先,对三种不同的方法进行了解释和比较,这些方法可以在有关该主题的科学论文中找到。然后,我们展示了Duffing振荡器实验的S曲线测量,我们解析地导出了最优控制器增益。导出的用于稳定PD控制器增益的公式使得不需要对合适值进行试错搜索。由于反馈控制在驱动信号中引入了更高的谐波,我们考虑强制信号的协调。在处理非线性频率响应时,这种协调对于减少振动筛-结构的相互作用非常重要。最后,通过一种适用于数值分析的连续算法来增强受控非线性测试和协调,并将其应用于几何非线性梁试验台,我们直接在位移频率平面上测量非线性强迫响应。
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引用次数: 2
A family of total Lagrangian Petrov–Galerkin Cosserat rod finite element formulations 一类全拉格朗日Petrov–Galerkin-Cosserat杆有限元公式
Q1 Mathematics Pub Date : 2023-05-08 DOI: 10.1002/gamm.202300008
Simon R. Eugster, Jonas Harsch

The standard in rod finite element formulations is the Bubnov–Galerkin projection method, where the test functions arise from a consistent variation of the ansatz functions. This approach becomes increasingly complex when highly nonlinear ansatz functions are chosen to approximate the rod's centerline and cross-section orientations. Using a Petrov–Galerkin projection method, we propose a whole family of rod finite element formulations where the nodal generalized virtual displacements and generalized velocities are interpolated instead of using the consistent variations and time derivatives of the ansatz functions. This approach leads to a significant simplification of the expressions in the discrete virtual work functionals. In addition, independent strategies can be chosen for interpolating the nodal centerline points and cross-section orientations. We discuss three objective interpolation strategies and give an in-depth analysis concerning locking and convergence behavior for the whole family of rod finite element formulations.

杆有限元公式中的标准是Bubnov–Galerkin投影法,其中测试函数源于模拟函数的一致变化。当选择高度非线性的模拟函数来近似杆的中心线和横截面方向时,这种方法变得越来越复杂。使用Petrov–Galerkin投影方法,我们提出了一整套杆件有限元公式,其中节点广义虚拟位移和广义速度是插值的,而不是使用ansatz函数的一致变化和时间导数。这种方法大大简化了离散虚功泛函中的表达式。此外,可以选择独立的策略来插值节点中心线点和截面方向。我们讨论了三种目标插值策略,并对整个杆有限元族的锁定和收敛行为进行了深入分析。
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引用次数: 3
Stationary solutions in applied dynamics: A unified framework for the numerical calculation and stability assessment of periodic and quasi-periodic solutions based on invariant manifolds 应用动力学中的平稳解:基于不变流形的周期和准周期解的数值计算和稳定性评估的统一框架
Q1 Mathematics Pub Date : 2023-04-26 DOI: 10.1002/gamm.202300006
Hartmut Hetzler, Simon Bäuerle

The determination of stationary solutions of dynamical systems as well as analyzing their stability is of high relevance in science and engineering. For static and periodic solutions a lot of methods are available to find stationary motions and analyze their stability. In contrast, there are only few approaches to find stationary solutions to the important class of quasi-periodic motions–which represent solutions of generalized periodicity–available so far. Furthermore, no generally applicable approach to determine their stability is readily available. This contribution presents a unified framework for the analysis of equilibria, periodic as well as quasi-periodic motions alike. To this end, the dynamical problem is changed from a formulation in terms of the trajectory to an alternative formulation based on the invariant manifold as geometrical object in the state space. Using a so-called hypertime parametrization offers a direct relation between the frequency base of the solution and the parametrization of the invariant manifold. Over the domain of hypertimes, the invariant manifold is given as solution to a PDE, which can be solved using standard methods as Finite Differences (FD), Fourier-Galerkin-methods (FGM) or quasi-periodic shooting (QPS). As a particular advantage, the invariant manifold represents the entire stationary dynamics on a finite domain even for quasi-periodic motions – whereas obtaining the same information from trajectories would require knowing them over an infinite time interval. Based on the invariant manifold, a method for stability assessment of quasi-periodic solutions by means of efficient calculation of Lyapunov-exponents is devised. Here, the basic idea is to introduce a Generalized Monodromy Mapping, which may be determined in a pre-processing step: using this mapping, the Lyapunov-exponents may efficiently be calculated by iterating this mapping.

动力系统平稳解的确定及其稳定性分析在科学和工程中具有重要意义。对于静态解和周期解,有很多方法可以找到静态运动并分析其稳定性。相比之下,到目前为止,只有很少的方法可以找到一类重要的准周期运动的平稳解,这类运动代表了广义周期性的解。此外,没有普遍适用的方法来确定它们的稳定性。这一贡献为平衡分析提供了一个统一的框架,包括周期运动和准周期运动。为此,动力学问题从根据轨迹的公式变为基于状态空间中作为几何对象的不变流形的替代公式。使用所谓的超时间参数化提供了解的频基和不变流形的参数化之间的直接关系。在超时间域上,给出了不变流形作为PDE的解,它可以使用有限差分(FD)、傅立叶-伽辽金方法(FGM)或准周期射击(QPS)等标准方法来求解。作为一个特殊的优势,不变流形代表了有限域上的整个平稳动力学,即使是准周期运动——而从轨迹中获得相同的信息需要在无限的时间间隔内了解它们。基于不变流形,设计了一种通过有效计算李雅普诺夫指数来评估拟周期解稳定性的方法。在这里,基本思想是引入一个广义单调映射,该映射可以在预处理步骤中确定:使用该映射,可以通过迭代该映射来有效地计算李雅普诺夫指数。
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引用次数: 2
Dynamic human body models in vehicle safety: An overview 车辆安全中的动态人体模型:综述
Q1 Mathematics Pub Date : 2023-04-26 DOI: 10.1002/gamm.202300007
N. Fahse, M. Millard, F. Kempter, S. Maier, M. Roller, J. Fehr

Significant trends in the vehicle industry are autonomous driving, micromobility, electrification and the increased use of shared mobility solutions. These new vehicle automation and mobility classes lead to a larger number of occupant positions, interiors and load directions. As safety systems interact with and protect occupants, it is essential to place the human, with its variability and vulnerability, at the center of the design and operation of these systems. Digital human body models (HBMs) can help meet these requirements and are therefore increasingly being integrated into the development of new vehicle models. This contribution provides an overview of current HBMs and their applications in vehicle safety in different driving modes. The authors briefly introduce the underlying mathematical methods and present a selection of HBMs to the reader. An overview table with guideline values for simulation times, common applications and available variants of the models is provided. To provide insight into the broad application of HBMs, the authors present three case studies in the field of vehicle safety: (i) in-crash finite element simulations and injuries of riders on a motorcycle; (ii) scenario-based assessment of the active pre-crash behavior of occupants with the Madymo multibody HBM; (iii) prediction of human behavior in a take-over scenario using the EMMA model.

汽车行业的显著趋势是自动驾驶、微型车、电动化和共享出行解决方案的使用增加。这些新的车辆自动化和移动性级别带来了更多的乘员位置、内部和负载方向。当安全系统与乘客互动并保护乘客时,至关重要的是将人类及其可变性和脆弱性置于这些系统设计和操作的中心。数字人体模型(HBM)可以帮助满足这些要求,因此越来越多地被集成到新车型的开发中。这篇文章概述了当前的HBM及其在不同驾驶模式下的车辆安全中的应用。作者简要介绍了基本的数学方法,并向读者介绍了一些HBM。提供了一个概述表,其中包含模拟时间、常见应用程序和可用模型变体的指导值。为了深入了解HBM的广泛应用,作者介绍了车辆安全领域的三个案例研究:(i)在碰撞有限元模拟和摩托车驾驶员受伤中;(ii)使用Madymo多体HBM的乘员碰撞前主动行为的基于场景的评估;(iii)使用EMMA模型预测接管场景中的人类行为。
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引用次数: 4
Preface to the topical issue on applied and nonlinear dynamics: Part I 应用动力学与非线性动力学专题论文前言:第一部分
Q1 Mathematics Pub Date : 2023-03-07 DOI: 10.1002/gamm.202300005
Jörg Fehr, Kristin de Payrebrune, Robert Seifried
The current special issue of the GAMM Mitteilungen, which is the first of a two-part series, contains several contributions on the topic of applied and nonlinear dynamics. Dynamical problems occur in a wide range of engineering systems, such as all kinds of vehicles, wind power plants, turbines, engines, machine tools or in robotics, ranging from industrial robotics to service and medical robots. Dynamical questions are also essential in the modeling of biomechanical systems, for example in the description of the (human) musculoskeletal system or in the development of human dummies for crash tests. Nowadays a wide range of analytical, numerical, data-based and experimental tools and methods exists to foster the investigation of all kinds of dynamical systems. Hereby also the issue of model reduction plays an increasingly important role. Modern dynamical systems are often active systems, thus methods from system dynamics and control theory have to be included. This important connection between these communities is also reflected in the GAMM activity group (Fachausschuss) “Dynamics and Control Theory.” Many researchers contributing to this topical issue on applied and nonlinear dynamics are members of this GAMM activity group. We are very happy that several teams of authors have accepted our invitation to report on recent developments, research highlights and emerging application areas in applied and nonlinear dynamics. The four papers in this first part of the topical issue on applied and nonlinear dynamics are devoted to the above mentioned topics. The first paper [1] presents a minimal model for investigation of the influence of equilibrium positions on brake squeal. Paper [2] deals with an interpolation-based parametric model order reduction of automotive brake systems for frequency-domain analyses. In the contribution [3] nonlinear vibration phenomena in hydrodynamically supported rotor systems are discussed. Finally the last paper [4] presents the application of stable inversion methods to flexible manipulators modeled by the absolute nodal coordinate formulation for feedforward control design.
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引用次数: 0
Nonlinear vibration phenomena in hydrodynamically supported rotor systems 流体动力支承转子系统的非线性振动现象
Q1 Mathematics Pub Date : 2023-03-07 DOI: 10.1002/gamm.202300003
Steffen Nitzschke, Elmar Woschke, Cornelius Strackeljan

It is a well-known fact, that hydrodynamically supported systems are prone to nonlinear vibrations. Their exact simulative prediction with respect to frequency and amplitude is complicated by the fact that different system properties interact. The paper at hand outlines an approach that takes all relevant influences like rigid body motions, elastic deformations, nonlinear relation between fluid film pressure and bearing kinematics as well as temperature increase due to power loss or adjacent heat sources into account as detailed as necessary. Both journal and thrust bearings are considered as they contribute to the system's stiffness and damping capabilities. The approach is applied to self-excited pad vibrations of tilting pad thrust bearings as well as the run-up simulation of a turbocharger rotor under different axial loads. Both models are validated against measurements.

众所周知,流体动力支撑系统容易产生非线性振动。由于不同的系统特性相互作用,它们对频率和振幅的精确模拟预测变得复杂。手头的论文概述了一种方法,该方法考虑了所有相关影响,如刚体运动、弹性变形、流体膜压力和轴承运动学之间的非线性关系,以及由于功率损失或相邻热源导致的温度升高,并在必要时进行了详细考虑。轴颈轴承和推力轴承都被认为有助于系统的刚度和阻尼能力。该方法应用于可倾瓦推力轴承的自激瓦振动以及不同轴向载荷下涡轮增压器转子的助跑仿真。两个模型都经过了测量验证。
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引用次数: 1
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